                         SEQUENCE LISTING

<110>  Nottingham University Hospitals NHS Trust
 
<120>  Cancer Biomarkers

<130>  JA93736P.WOP

<150>  1807879.0
<151>  2018-05-15

<150>  1817968.9
<151>  2018-11-02

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  1193
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Trp Arg Val Lys Lys Leu Ser Leu Ser Leu Ser Pro Ser Pro Gln 
1               5                   10                  15      


Thr Gly Lys Pro Ser Met Arg Thr Pro Leu Arg Glu Leu Thr Leu Gln 
            20                  25                  30          


Pro Gly Ala Leu Thr Asn Ser Gly Lys Arg Ser Pro Ala Cys Ser Ser 
        35                  40                  45              


Leu Thr Pro Ser Leu Cys Lys Leu Gly Leu Gln Glu Gly Ser Asn Asn 
    50                  55                  60                  


Ser Ser Pro Val Asp Phe Val Asn Asn Lys Arg Thr Asp Leu Ser Ser 
65                  70                  75                  80  


Glu His Phe Ser His Ser Ser Lys Trp Leu Glu Thr Cys Gln His Glu 
                85                  90                  95      


Ser Asp Glu Gln Pro Leu Asp Pro Ile Pro Gln Ile Ser Ser Thr Pro 
            100                 105                 110         


Lys Thr Ser Glu Glu Ala Val Asp Pro Leu Gly Asn Tyr Met Val Lys 
        115                 120                 125             


Thr Ile Val Leu Val Pro Ser Pro Leu Gly Gln Gln Gln Asp Met Ile 
    130                 135                 140                 


Phe Glu Ala Arg Leu Asp Thr Met Ala Glu Thr Asn Ser Ile Ser Leu 
145                 150                 155                 160 


Asn Gly Pro Leu Arg Thr Asp Asp Leu Val Arg Glu Glu Val Ala Pro 
                165                 170                 175     


Cys Met Gly Asp Arg Phe Ser Glu Val Ala Ala Val Ser Glu Lys Pro 
            180                 185                 190         


Ile Phe Gln Glu Ser Pro Ser His Leu Leu Glu Glu Ser Pro Pro Asn 
        195                 200                 205             


Pro Cys Ser Glu Gln Leu His Cys Ser Lys Glu Ser Leu Ser Ser Arg 
    210                 215                 220                 


Thr Glu Ala Val Arg Glu Asp Leu Val Pro Ser Glu Ser Asn Ala Phe 
225                 230                 235                 240 


Leu Pro Ser Ser Val Leu Trp Leu Ser Pro Ser Thr Ala Leu Ala Ala 
                245                 250                 255     


Asp Phe Arg Val Asn His Val Asp Pro Glu Glu Glu Ile Val Glu His 
            260                 265                 270         


Gly Ala Met Glu Glu Arg Glu Met Arg Phe Pro Thr His Pro Lys Glu 
        275                 280                 285             


Ser Glu Thr Glu Asp Gln Ala Leu Val Ser Ser Val Glu Asp Ile Leu 
    290                 295                 300                 


Ser Thr Cys Leu Thr Pro Asn Leu Val Glu Met Glu Ser Gln Glu Ala 
305                 310                 315                 320 


Pro Gly Pro Ala Val Glu Asp Val Gly Arg Ile Leu Gly Ser Asp Thr 
                325                 330                 335     


Glu Ser Trp Met Ser Pro Leu Ala Trp Leu Glu Lys Gly Val Asn Thr 
            340                 345                 350         


Ser Val Met Leu Glu Asn Leu Arg Gln Ser Leu Ser Leu Pro Ser Met 
        355                 360                 365             


Leu Arg Asp Ala Ala Ile Gly Thr Thr Pro Phe Ser Thr Cys Ser Val 
    370                 375                 380                 


Gly Thr Trp Phe Thr Pro Ser Ala Pro Gln Glu Lys Ser Thr Asn Thr 
385                 390                 395                 400 


Ser Gln Thr Gly Leu Val Gly Thr Lys His Ser Thr Ser Glu Thr Glu 
                405                 410                 415     


Gln Leu Leu Cys Gly Arg Pro Pro Asp Leu Thr Ala Leu Ser Arg His 
            420                 425                 430         


Asp Leu Glu Asp Asn Leu Leu Ser Ser Leu Val Ile Leu Glu Val Leu 
        435                 440                 445             


Ser Arg Gln Leu Arg Asp Trp Lys Ser Gln Leu Ala Val Pro His Pro 
    450                 455                 460                 


Glu Thr Gln Asp Ser Ser Thr Gln Thr Asp Thr Ser His Ser Gly Ile 
465                 470                 475                 480 


Thr Asn Lys Leu Gln His Leu Lys Glu Ser His Glu Met Gly Gln Ala 
                485                 490                 495     


Leu Gln Gln Ala Arg Asn Val Met Gln Ser Trp Val Leu Ile Ser Lys 
            500                 505                 510         


Glu Leu Ile Ser Leu Leu His Leu Ser Leu Leu His Leu Glu Glu Asp 
        515                 520                 525             


Lys Thr Thr Val Ser Gln Glu Ser Arg Arg Ala Glu Thr Leu Val Cys 
    530                 535                 540                 


Cys Cys Phe Asp Leu Leu Lys Lys Leu Arg Ala Lys Leu Gln Ser Leu 
545                 550                 555                 560 


Lys Ala Glu Arg Glu Glu Ala Arg His Arg Glu Glu Met Ala Leu Arg 
                565                 570                 575     


Gly Lys Asp Ala Ala Glu Ile Val Leu Glu Ala Phe Cys Ala His Ala 
            580                 585                 590         


Ser Gln Arg Ile Ser Gln Leu Glu Gln Asp Leu Ala Ser Met Arg Glu 
        595                 600                 605             


Phe Arg Gly Leu Leu Lys Asp Ala Gln Thr Gln Leu Val Gly Leu His 
    610                 615                 620                 


Ala Lys Gln Glu Glu Leu Val Gln Gln Thr Val Ser Leu Thr Ser Thr 
625                 630                 635                 640 


Leu Gln Gln Asp Trp Arg Ser Met Gln Leu Asp Tyr Thr Thr Trp Thr 
                645                 650                 655     


Ala Leu Leu Ser Arg Ser Arg Gln Leu Thr Glu Lys Leu Thr Val Lys 
            660                 665                 670         


Ser Gln Gln Ala Leu Gln Glu Arg Asp Val Ala Ile Glu Glu Lys Gln 
        675                 680                 685             


Glu Val Ser Arg Val Leu Glu Gln Val Ser Ala Gln Leu Glu Glu Cys 
    690                 695                 700                 


Lys Gly Gln Thr Glu Gln Leu Glu Leu Glu Asn Ser Arg Leu Ala Thr 
705                 710                 715                 720 


Asp Leu Arg Ala Gln Leu Gln Ile Leu Ala Asn Met Asp Ser Gln Leu 
                725                 730                 735     


Lys Glu Leu Gln Ser Gln His Thr His Cys Ala Gln Asp Leu Ala Met 
            740                 745                 750         


Lys Asp Glu Leu Leu Cys Gln Leu Thr Gln Ser Asn Glu Glu Gln Ala 
        755                 760                 765             


Ala Gln Trp Gln Lys Glu Glu Met Ala Leu Lys His Met Gln Ala Glu 
    770                 775                 780                 


Leu Gln Gln Gln Gln Ala Val Leu Ala Lys Glu Val Arg Asp Leu Lys 
785                 790                 795                 800 


Glu Thr Leu Glu Phe Ala Asp Gln Glu Asn Gln Val Ala His Leu Glu 
                805                 810                 815     


Leu Gly Gln Val Glu Cys Gln Leu Lys Thr Thr Leu Glu Val Leu Arg 
            820                 825                 830         


Glu Arg Ser Leu Gln Cys Glu Asn Leu Lys Asp Thr Val Glu Asn Leu 
        835                 840                 845             


Thr Ala Lys Leu Ala Ser Thr Ile Ala Asp Asn Gln Glu Gln Asp Leu 
    850                 855                 860                 


Glu Lys Thr Arg Gln Tyr Ser Gln Lys Leu Gly Leu Leu Thr Glu Gln 
865                 870                 875                 880 


Leu Gln Ser Leu Thr Leu Phe Leu Gln Thr Lys Leu Lys Glu Lys Thr 
                885                 890                 895     


Glu Gln Glu Thr Leu Leu Leu Ser Thr Ala Cys Pro Pro Thr Gln Glu 
            900                 905                 910         


His Pro Leu Pro Asn Asp Arg Thr Phe Leu Gly Ser Ile Leu Thr Ala 
        915                 920                 925             


Val Ala Asp Glu Glu Pro Glu Ser Thr Pro Val Pro Leu Leu Gly Ser 
    930                 935                 940                 


Asp Lys Ser Ala Phe Thr Arg Val Ala Ser Met Val Ser Leu Gln Pro 
945                 950                 955                 960 


Ala Glu Thr Pro Gly Met Glu Glu Ser Leu Ala Glu Met Ser Ile Met 
                965                 970                 975     


Thr Thr Glu Leu Gln Ser Leu Cys Ser Leu Leu Gln Glu Ser Lys Glu 
            980                 985                 990         


Glu Ala Ile Arg Thr Leu Gln Arg  Lys Ile Cys Glu Leu  Gln Ala Arg 
        995                 1000                 1005             


Leu Gln  Ala Gln Glu Glu Gln  His Gln Glu Val Gln  Lys Ala Lys 
    1010                 1015                 1020             


Glu Ala  Asp Ile Glu Lys Leu  Asn Gln Ala Leu Cys  Leu Arg Tyr 
    1025                 1030                 1035             


Lys Asn  Glu Lys Glu Leu Gln  Glu Val Ile Gln Gln  Gln Asn Glu 
    1040                 1045                 1050             


Lys Ile  Leu Glu Gln Ile Asp  Lys Ser Gly Glu Leu  Ile Ser Leu 
    1055                 1060                 1065             


Arg Glu  Glu Val Thr His Leu  Thr Arg Ser Leu Arg  Arg Ala Glu 
    1070                 1075                 1080             


Thr Glu  Thr Lys Val Leu Gln  Glu Ala Leu Ala Gly  Gln Leu Asp 
    1085                 1090                 1095             


Ser Asn  Cys Gln Pro Met Ala  Thr Asn Trp Ile Gln  Glu Lys Val 
    1100                 1105                 1110             


Trp Leu  Ser Gln Glu Val Asp  Lys Leu Arg Val Met  Phe Leu Glu 
    1115                 1120                 1125             


Met Lys  Asn Glu Lys Glu Lys  Leu Met Ile Lys Phe  Gln Ser His 
    1130                 1135                 1140             


Arg Asn  Ile Leu Glu Glu Asn  Leu Arg Arg Ser Asp  Lys Glu Leu 
    1145                 1150                 1155             


Glu Lys  Leu Asp Asp Ile Val  Gln His Ile Tyr Lys  Thr Leu Leu 
    1160                 1165                 1170             


Ser Ile  Pro Glu Val Val Arg  Gly Cys Lys Glu Leu  Gln Gly Leu 
    1175                 1180                 1185             


Leu Glu  Phe Leu Ser 
    1190             


<210>  2
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Met Thr Leu His Thr Lys Ala Ser Gly Met Ala Leu Leu His 
1               5                   10                  15      


Gln Ile Gln Gly Asn Glu Leu Glu Pro Leu Asn Arg Pro Gln Leu Lys 
            20                  25                  30          


Ile Pro Leu Glu Arg Pro Leu Gly Glu Val Tyr Leu Asp Ser Ser Lys 
        35                  40                  45              


Pro Ala Val Tyr Asn Tyr Pro Glu Gly Ala Ala Tyr Glu Phe Asn Ala 
    50                  55                  60                  


Ala Ala Ala Ala Asn Ala Gln Val Tyr Gly Gln Thr Gly Leu Pro Tyr 
65                  70                  75                  80  


Gly Pro Gly Ser Glu Ala Ala Ala Phe Gly Ser Asn Gly Leu Gly Gly 
                85                  90                  95      


Phe Pro Pro Leu Asn Ser Val Ser Pro Ser Pro Leu Met Leu Leu His 
            100                 105                 110         


Pro Pro Pro Gln Leu Ser Pro Phe Leu Gln Pro His Gly Gln Gln Val 
        115                 120                 125             


Pro Tyr Tyr Leu Glu Asn Glu Pro Ser Gly Tyr Thr Val Arg Glu Ala 
    130                 135                 140                 


Gly Pro Pro Ala Phe Tyr Arg Pro Asn Ser Asp Asn Arg Arg Gln Gly 
145                 150                 155                 160 


Gly Arg Glu Arg Leu Ala Ser Thr Asn Asp Lys Gly Ser Met Ala Met 
                165                 170                 175     


Glu Ser Ala Lys Glu Thr Arg Tyr Cys Ala Val Cys Asn Asp Tyr Ala 
            180                 185                 190         


Ser Gly Tyr His Tyr Gly Val Trp Ser Cys Glu Gly Cys Lys Ala Phe 
        195                 200                 205             


Phe Lys Arg Ser Ile Gln Gly His Asn Asp Tyr Met Cys Pro Ala Thr 
    210                 215                 220                 


Asn Gln Cys Thr Ile Asp Lys Asn Arg Arg Lys Ser Cys Gln Ala Cys 
225                 230                 235                 240 


Arg Leu Arg Lys Cys Tyr Glu Val Gly Met Met Lys Gly Gly Ile Arg 
                245                 250                 255     


Lys Asp Arg Arg Gly Gly Arg Met Leu Lys His Lys Arg Gln Arg Asp 
            260                 265                 270         


Asp Gly Glu Gly Arg Gly Glu Val Gly Ser Ala Gly Asp Met Arg Ala 
        275                 280                 285             


Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn 
    290                 295                 300                 


Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu 
305                 310                 315                 320 


Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro 
                325                 330                 335     


Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg 
            340                 345                 350         


Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val 
        355                 360                 365             


Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu 
    370                 375                 380                 


Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Gly 
385                 390                 395                 400 


Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys 
                405                 410                 415     


Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser 
            420                 425                 430         


Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu 
        435                 440                 445             


Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser 
    450                 455                 460                 


Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp 
465                 470                 475                 480 


Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr 
                485                 490                 495     


Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser 
            500                 505                 510         


His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met 
        515                 520                 525             


Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu 
    530                 535                 540                 


Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val 
545                 550                 555                 560 


Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser 
                565                 570                 575     


His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro 
            580                 585                 590         


Ala Thr Val 
        595 


<210>  3
<211>  1255
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                645                 650                 655     


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            660                 665                 670         


Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg 
        675                 680                 685             


Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly 
    690                 695                 700                 


Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu 
705                 710                 715                 720 


Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 
                725                 730                 735     


Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile 
            740                 745                 750         


Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu 
        755                 760                 765             


Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg 
    770                 775                 780                 


Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu 
785                 790                 795                 800 


Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg 
                805                 810                 815     


Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly 
            820                 825                 830         


Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala 
        835                 840                 845             


Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe 
    850                 855                 860                 


Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp 
865                 870                 875                 880 


Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg 
                885                 890                 895     


Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val 
            900                 905                 910         


Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala 
        915                 920                 925             


Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro 
    930                 935                 940                 


Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met 
945                 950                 955                 960 


Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe 
                965                 970                 975     


Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu 
            980                 985                 990         


Asp Leu Gly Pro Ala Ser Pro Leu  Asp Ser Thr Phe Tyr  Arg Ser Leu 
        995                 1000                 1005             


Leu Glu  Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr 
    1010                 1015                 1020             


Leu Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
    1025                 1030                 1035             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1040                 1045                 1050             


Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 
    1055                 1060                 1065             


Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 
    1070                 1075                 1080             


Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 
    1085                 1090                 1095             


Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 
    1100                 1105                 1110             


Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 
    1115                 1120                 1125             


Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 
    1130                 1135                 1140             


Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 
    1145                 1150                 1155             


Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 
    1160                 1165                 1170             


Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 
    1175                 1180                 1185             


Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 
    1190                 1195                 1200             


Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 
    1205                 1210                 1215             


Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 
    1220                 1225                 1230             


Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 
    1235                 1240                 1245             


Leu Gly  Leu Asp Val Pro Val  
    1250                 1255 


