                         SEQUENCE LISTING

<110>  UCL Business PLC
 
<120>  Chimeric antigen receptor

<130>  P113774PCT

<140>  PCT/GB2019/051329
<141>  2019-05-15

<150>  GB 1807862.6
<151>  2018-05-15

<160>  64    

<170>  PatentIn version 3.5

<210>  1
<211>  1032
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Ala Ala Gly Leu Leu Gly Val Phe Leu Ala Leu Val Ala Pro 
1               5                   10                  15      


Gly Val Leu Gly Ile Ser Cys Gly Ser Pro Pro Pro Ile Leu Asn Gly 
            20                  25                  30          


Arg Ile Ser Tyr Tyr Ser Thr Pro Ile Ala Val Gly Thr Val Ile Arg 
        35                  40                  45              


Tyr Ser Cys Ser Gly Thr Phe Arg Leu Ile Gly Glu Lys Ser Leu Leu 
    50                  55                  60                  


Cys Ile Thr Lys Asp Lys Val Asp Gly Thr Trp Asp Lys Pro Ala Pro 
65                  70                  75                  80  


Lys Cys Glu Tyr Phe Asn Lys Tyr Ser Ser Cys Pro Glu Pro Ile Val 
                85                  90                  95      


Pro Gly Gly Tyr Lys Ile Arg Gly Ser Thr Pro Tyr Arg His Gly Asp 
            100                 105                 110         


Ser Val Thr Phe Ala Cys Lys Thr Asn Phe Ser Met Asn Gly Asn Lys 
        115                 120                 125             


Ser Val Trp Cys Gln Ala Asn Asn Met Trp Gly Pro Thr Arg Leu Pro 
    130                 135                 140                 


Thr Cys Val Ser Val Phe Pro Leu Glu Cys Pro Ala Leu Pro Met Ile 
145                 150                 155                 160 


His Asn Gly His His Thr Ser Glu Asn Val Gly Ser Ile Ala Pro Gly 
                165                 170                 175     


Leu Ser Val Thr Tyr Ser Cys Glu Ser Gly Tyr Leu Leu Val Gly Glu 
            180                 185                 190         


Lys Ile Ile Asn Cys Leu Ser Ser Gly Lys Trp Ser Ala Val Pro Pro 
        195                 200                 205             


Thr Cys Glu Glu Ala Arg Cys Lys Ser Leu Gly Arg Phe Pro Asn Gly 
    210                 215                 220                 


Lys Val Lys Glu Pro Pro Ile Leu Arg Val Gly Val Thr Ala Asn Phe 
225                 230                 235                 240 


Phe Cys Asp Glu Gly Tyr Arg Leu Gln Gly Pro Pro Ser Ser Arg Cys 
                245                 250                 255     


Val Ile Ala Gly Gln Gly Val Ala Trp Thr Lys Met Pro Val Cys Glu 
            260                 265                 270         


Glu Ile Phe Cys Pro Ser Pro Pro Pro Ile Leu Asn Gly Arg His Ile 
        275                 280                 285             


Gly Asn Ser Leu Ala Asn Val Ser Tyr Gly Ser Ile Val Thr Tyr Thr 
    290                 295                 300                 


Cys Asp Pro Asp Pro Glu Glu Gly Val Asn Phe Ile Leu Ile Gly Glu 
305                 310                 315                 320 


Ser Thr Leu Arg Cys Thr Val Asp Ser Gln Lys Thr Gly Thr Trp Ser 
                325                 330                 335     


Gly Pro Ala Pro Arg Cys Glu Leu Ser Thr Ser Ala Val Gln Cys Pro 
            340                 345                 350         


His Pro Gln Ile Leu Arg Gly Arg Met Val Ser Gly Gln Lys Asp Arg 
        355                 360                 365             


Tyr Thr Tyr Asn Asp Thr Val Ile Phe Ala Cys Met Phe Gly Phe Thr 
    370                 375                 380                 


Leu Lys Gly Ser Lys Gln Ile Arg Cys Asn Ala Gln Gly Thr Trp Glu 
385                 390                 395                 400 


Pro Ser Ala Pro Val Cys Glu Lys Glu Cys Gln Ala Pro Pro Asn Ile 
                405                 410                 415     


Leu Asn Gly Gln Lys Glu Asp Arg His Met Val Arg Phe Asp Pro Gly 
            420                 425                 430         


Thr Ser Ile Lys Tyr Ser Cys Asn Pro Gly Tyr Val Leu Val Gly Glu 
        435                 440                 445             


Glu Ser Ile Gln Cys Thr Ser Glu Gly Val Trp Thr Pro Pro Val Pro 
    450                 455                 460                 


Gln Cys Lys Val Ala Ala Cys Glu Ala Thr Gly Arg Gln Leu Leu Thr 
465                 470                 475                 480 


Lys Pro Gln His Gln Phe Val Arg Pro Asp Val Asn Ser Ser Cys Gly 
                485                 490                 495     


Glu Gly Tyr Lys Leu Ser Gly Ser Val Tyr Gln Glu Cys Gln Gly Thr 
            500                 505                 510         


Ile Pro Trp Phe Met Glu Ile Arg Leu Cys Lys Glu Ile Thr Cys Pro 
        515                 520                 525             


Pro Pro Pro Val Ile Tyr Asn Gly Ala His Thr Gly Ser Ser Leu Glu 
    530                 535                 540                 


Asp Phe Pro Tyr Gly Thr Thr Val Thr Tyr Thr Cys Asn Pro Gly Pro 
545                 550                 555                 560 


Glu Arg Gly Val Glu Phe Ser Leu Ile Gly Glu Ser Thr Ile Arg Cys 
                565                 570                 575     


Thr Ser Asn Asp Gln Glu Arg Gly Thr Trp Ser Gly Pro Ala Pro Leu 
            580                 585                 590         


Cys Lys Leu Ser Leu Leu Ala Val Gln Cys Ser His Val His Ile Ala 
        595                 600                 605             


Asn Gly Tyr Lys Ile Ser Gly Lys Glu Ala Pro Tyr Phe Tyr Asn Asp 
    610                 615                 620                 


Thr Val Thr Phe Lys Cys Tyr Ser Gly Phe Thr Leu Lys Gly Ser Ser 
625                 630                 635                 640 


Gln Ile Arg Cys Lys Ala Asp Asn Thr Trp Asp Pro Glu Ile Pro Val 
                645                 650                 655     


Cys Glu Lys Glu Thr Cys Gln His Val Arg Gln Ser Leu Gln Glu Leu 
            660                 665                 670         


Pro Ala Gly Ser Arg Val Glu Leu Val Asn Thr Ser Cys Gln Asp Gly 
        675                 680                 685             


Tyr Gln Leu Thr Gly His Ala Tyr Gln Met Cys Gln Asp Ala Glu Asn 
    690                 695                 700                 


Gly Ile Trp Phe Lys Lys Ile Pro Leu Cys Lys Val Ile His Cys His 
705                 710                 715                 720 


Pro Pro Pro Val Ile Val Asn Gly Lys His Thr Gly Met Met Ala Glu 
                725                 730                 735     


Asn Phe Leu Tyr Asn Glu Val Ser Tyr Glu Cys Asp Gln Gly Phe Tyr 
            740                 745                 750         


Leu Leu Gly Glu Lys Lys Leu Gln Cys Arg Ser Asp Ser Lys Gly His 
        755                 760                 765             


Gly Ser Trp Ser Gly Pro Ser Pro Gln Cys Leu Arg Ser Pro Pro Val 
    770                 775                 780                 


Thr Arg Cys Pro Asn Pro Glu Val Lys His Gly Tyr Lys Leu Asn Lys 
785                 790                 795                 800 


Thr His Ser Ala Tyr Ser His Asn Asp Ile Val Tyr Val Asp Cys Asn 
                805                 810                 815     


Pro Gly Phe Ile Met Asn Gly Ser Arg Val Ile Arg Cys His Thr Asp 
            820                 825                 830         


Asn Thr Trp Val Pro Gly Val Pro Thr Cys Ile Lys Lys Ala Phe Ile 
        835                 840                 845             


Gly Cys Pro Pro Pro Pro Lys Thr Pro Asn Gly Asn His Thr Gly Gly 
    850                 855                 860                 


Asn Ile Ala Arg Phe Ser Pro Gly Met Ser Ile Leu Tyr Ser Cys Asp 
865                 870                 875                 880 


Gln Gly Tyr Leu Leu Val Gly Glu Ala Leu Leu Leu Cys Thr His Glu 
                885                 890                 895     


Gly Thr Trp Ser Gln Pro Ala Pro His Cys Lys Glu Val Asn Cys Ser 
            900                 905                 910         


Ser Pro Ala Asp Met Asp Gly Ile Gln Lys Gly Leu Glu Pro Arg Lys 
        915                 920                 925             


Met Tyr Gln Tyr Gly Ala Val Val Thr Leu Glu Cys Glu Asp Gly Tyr 
    930                 935                 940                 


Met Leu Glu Gly Ser Pro Gln Ser Gln Cys Gln Ser Asp His Gln Trp 
945                 950                 955                 960 


Asn Pro Pro Leu Ala Val Cys Arg Ser Arg Ser Leu Ala Pro Val Leu 
                965                 970                 975     


Cys Gly Ile Ala Ala Gly Leu Ile Leu Leu Thr Phe Leu Ile Val Ile 
            980                 985                 990         


Thr Leu Tyr Val Ile Ser Lys His  Arg Ala Arg Asn Tyr  Tyr Thr Asp 
        995                 1000                 1005             


Thr Ser  Gln Lys Glu Ala Phe  His Leu Glu Ala Arg  Glu Val Tyr 
    1010                 1015                 1020             


Ser Val  Asp Pro Tyr Asn Pro  Ala Ser 
    1025                 1030         


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone MP27963 Variable Heavy Chain (VH) complementarity 
       determining region (CDR) CDR1

<400>  2

Gly Tyr Thr Phe Thr Ser Asn 
1               5           


<210>  3
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone MP27963 VH CDR2

<400>  3

Ser Pro Gly Asp Gly Asp 
1               5       


<210>  4
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone MP27963 VH CDR3

<400>  4

Gly Asp Ser Ser Gly Trp Gly Pro Asn Trp Phe Asp Ser 
1               5                   10              


<210>  5
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone MP27964 VH CDR2

<400>  5

Tyr Pro Gly Asp Gly Asp 
1               5       


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone MP27964 VH CDR3

<400>  6

Ser Gly Asp Gly Tyr Phe Asp Tyr 
1               5               


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone MP27965 VH CDR1

<400>  7

Gly Tyr Thr Phe Thr Thr Asn 
1               5           


<210>  8
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone MP27965 VH CDR2

<400>  8

Asn Pro Gly Asp Gly Asn 
1               5       


<210>  9
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone MP27965 VH CDR3

<400>  9

Gly Asp Tyr Ser Gly Trp Gly Pro Asn Trp Phe Asp Tyr 
1               5                   10              


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone MP27967 VH CDR1

<400>  10

Gly Tyr Asn Ile Arg Asn Thr 
1               5           


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone MP27967 VH CDR2

<400>  11

Asp Pro Ala Asn Gly Asp Thr 
1               5           


<210>  12
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone MP27967 VH CDR3

<400>  12

Arg Met Val Gly Thr Gly Gly Tyr Ala Met Asp Ala 
1               5                   10          


<210>  13
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone MP28132 VH CDR2

<400>  13

Tyr Arg Gly Asp Gly Asp 
1               5       


<210>  14
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone MP28132 VH CDR3

<400>  14

Gly Asp Ser Ser Gly Trp Gly Pro Asn Trp Phe Asp Ser 
1               5                   10              


<210>  15
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone MP27963 Variable Light Chain (VL) CDR1

<400>  15

Leu Ala Ser Gln Asp Ile Gly Asn Tyr Leu Ser 
1               5                   10      


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone MP27963 VL CDR2

<400>  16

Asp Val Asn Asn Leu Glu Asp 
1               5           


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone MP27963 VL CDR3

<400>  17

Gln Gln Tyr Tyr Glu Tyr Pro Leu Thr 
1               5                   


<210>  18
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone MP27964 VL CDR1

<400>  18

Arg Val Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone MP27964 VL CDR2

<400>  19

Glu Thr Ser Lys Leu Ala Ser 
1               5           


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone MP27964 VL CDR3

<400>  20

Gln Gln Trp Asn Phe Pro Leu Thr 
1               5               


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone MP27965 VL CDR1

<400>  21

Arg Ala Ser Glu Asp Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  22
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone MP27965 VL CDR2

<400>  22

Asp Ala Asn Asn Leu Ala Asp 
1               5           


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone MP27965 VL CDR3

<400>  23

Gln Gln Tyr Asn Asn Tyr Pro Leu Thr 
1               5                   


<210>  24
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone MP27966 VL CDR1

<400>  24

Leu Ala Ser Gln Asp Ile Gly Asp Tyr Leu Ser 
1               5                   10      


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone MP27966 VL CDR2

<400>  25

Gly Ala Thr Asn Leu Glu Asp 
1               5           


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone MP27966 VL CDR3

<400>  26

His Gln Tyr Tyr Gln Tyr Pro Leu Thr 
1               5                   


<210>  27
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone MP27967 VL CDR1

<400>  27

Arg Ala Ser Gln Ser Val Ser Ile Ser Ser Val Asn Leu Met Asn 
1               5                   10                  15  


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone MP27967 VL CDR2

<400>  28

His Ala Ser Asn Leu Ala Ser 
1               5           


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone MP27967 VL CDR3

<400>  29

Gln Gln Ser Arg Glu Ser Pro Trp Thr 
1               5                   


<210>  30
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  single-chain variable fragment (scFv) sequence

<400>  30

Glu Val His Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          


Phe Met His Trp Ile Lys Gln Gln Pro Gly Asn Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Asp Thr Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Asn Gly Lys Ala Ser Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Leu Ser Gly Asp Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Val Met 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Thr Thr Met Thr 
    130                 135                 140                 


Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Arg Val Ser Ser Ser 
145                 150                 155                 160 


Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Asp Ala Ser Pro Lys 
                165                 170                 175     


Pro Trp Ile Tyr Glu Thr Ser Lys Leu Ala Ser Gly Val Pro Asp Arg 
            180                 185                 190         


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Asn Asn 
        195                 200                 205             


Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Phe 
    210                 215                 220                 


Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
225                 230                 235             


<210>  31
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv sequence

<400>  31

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Asn 
            20                  25                  30          


Phe Met His Trp Ile Lys Gln Gln Pro Gly Asn Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Pro Gly Asp Gly Asn Thr Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Asn Val Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Gly Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Ser Gly Trp Gly Pro Asn Trp Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Asp Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ala Ser Leu Ser Ala Ser Leu Gly Glu Thr Val Thr Ile Glu Cys 
145                 150                 155                 160 


Arg Ala Ser Glu Asp Ile Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Asn Ser Pro Gln Leu Leu Ile His Asp Ala Asn Asn Leu Ala 
            180                 185                 190         


Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Tyr 
        195                 200                 205             


Ser Leu Lys Ile Asn Ser Leu Gln Ser Glu Asp Val Ala Ser Tyr Phe 
    210                 215                 220                 


Cys Gln Gln Tyr Asn Asn Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys Arg 
                245 


<210>  32
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv sequence

<400>  32

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Asn 
            20                  25                  30          


Phe Met His Trp Ile Lys Gln Gln Pro Gly Asn Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Pro Gly Asp Gly Asn Thr Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Asn Val Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Gly Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Ser Gly Trp Gly Pro Asn Trp Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Met Ser Ala Ser Leu Gly Asp Thr Val Thr Ile Thr Cys 
145                 150                 155                 160 


Leu Ala Ser Gln Asp Ile Gly Asp Tyr Leu Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ser Pro Lys Val Met Val Tyr Gly Ala Thr Asn Leu Glu 
            180                 185                 190         


Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Ser Asp Tyr 
        195                 200                 205             


Ser Leu Thr Ile Asn Ser Leu Gly Tyr Asp Asp Glu Gly Ile Tyr His 
    210                 215                 220                 


Cys His Gln Tyr Tyr Gln Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys Arg 
                245 


<210>  33
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv sequence

<400>  33

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Gly Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Val Ser Gly Tyr Asn Ile Arg Asn Thr 
            20                  25                  30          


Tyr Ile His Trp Val Asn Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Thr Ile Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Gln Leu Lys Ser Asp Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Met Arg Met Val Gly Thr Gly Gly Tyr Ala Met Asp Ala Trp Gly 
            100                 105                 110         


Gln Gly Ala Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Ser Val Ser Ile Ser Ser Val Asn Leu Met Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Gln Gln Pro Lys Leu Leu Ile Tyr His Ala Ser Asn 
            180                 185                 190         


Leu Ala Ser Gly Ile Pro Thr Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Asp Pro Val Gln Ala Asp Asp Ile Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Arg Glu Ser Pro Trp Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Leu Lys Arg 
                245         


<210>  34
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv sequence

<400>  34

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Glu Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          


Phe Met His Trp Ile Arg Gln Gln Pro Gly Asn Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Val Tyr Arg Gly Asp Gly Asp Thr Glu Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Asn Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Asp Ser Ser Gly Trp Gly Pro Asn Trp Phe Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ala Ser Leu Ser Ala Ser Leu Gly Glu Thr Val Thr Ile Glu Cys 
145                 150                 155                 160 


Arg Ala Ser Glu Asp Ile Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Asn Ser Pro Gln Leu Leu Ile Tyr Asp Ala Asn Ser Leu Ala 
            180                 185                 190         


Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Tyr 
        195                 200                 205             


Ser Leu Lys Ile Asn Ser Leu Gln Ser Glu Asp Val Ala Ser Tyr Phe 
    210                 215                 220                 


Cys Gln Gln Tyr Asn Asn Tyr Pro Leu Thr Phe Gly Ser Glu Thr Arg 
225                 230                 235                 240 


Leu Glu Ile Lys Arg 
                245 


<210>  35
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv sequence

<400>  35

Gln Val Gln Leu Gln Gln Ser Gly Ala Gln Leu Val Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Phe Thr Phe Ser Ser Ser 
            20                  25                  30          


Tyr Ile Ser Trp Leu Lys Gln Ala Pro Gly Gln Ser Phe Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Phe Ala Gly Asp Gly Gly Pro Asn Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Leu Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Trp Ala Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Ile Val Leu Thr Gln Ser Pro Thr Thr Thr Ala Ala Ser Pro Gly 
    130                 135                 140                 


Glu Lys Val Thr Ile Thr Cys Leu Ala Ser Ser Ser Ala Ser Asn Met 
145                 150                 155                 160 


Phe Trp Tyr Gln Gln Lys Ser Gly Asp Ser Pro Lys Leu Leu Ile Tyr 
                165                 170                 175     


Ser Thr Ser Ser Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
        195                 200                 205             


Asp Ala Ala Thr Tyr Tyr Cys Leu Gln Arg Ser Ser Tyr Pro Trp Thr 
    210                 215                 220                 


Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg 
225                 230                 235 


<210>  36
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv sequence

<400>  36

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Lys 
1               5                   10                  15      


Ser Leu Lys Leu Thr Cys Ala Thr Ser Gly Phe Thr Phe Ser Thr Ala 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ser Pro Asp Lys Arg Leu Glu Trp Ile 
        35                  40                  45              


Ala Arg Ile Lys Asp Lys Ser Lys Asn Tyr Ala Thr Asp Tyr Val Glu 
    50                  55                  60                  


Ala Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Glu Glu Asp Thr Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Gly Thr Tyr Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Val Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Thr 
    130                 135                 140                 


Thr Thr Ala Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Leu Ala 
145                 150                 155                 160 


Asn Ser Ser Val Ser Asn Met Tyr Trp Tyr Gln Gln Lys Ser Gly Ala 
                165                 170                 175     


Ser Pro Lys Leu Leu Ile Tyr Ser Thr Ser Arg Leu Ala Ser Gly Val 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Ser Ser Leu Thr 
        195                 200                 205             


Ile Asn Thr Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Trp Ser Ser Asp Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu 
225                 230                 235                 240 


Lys Arg 
        


<210>  37
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv sequence

<400>  37

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


His Ile Thr Trp Ile Lys Gln Thr Thr Gly Gln Gly Leu Glu Tyr Val 
        35                  40                  45              


Gly Tyr Ile Asn Thr Gly Ser Gly Thr Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Phe 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Pro Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Val Leu His Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Ile Val Met Thr Gln Gly Ala Leu Pro Asn Pro 
    130                 135                 140                 


Val Pro Ser Gly Glu Val Ala Ser Ile Thr Cys Gln Ser Ser Lys Ser 
145                 150                 155                 160 


Leu Leu His Ser Asn Gly Lys Thr Tyr Leu Asn Trp Tyr Leu Gln Arg 
                165                 170                 175     


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Trp Met Ser Thr Arg Ala 
            180                 185                 190         


Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Lys Ile Ser Ser Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Phe Leu Glu Tyr Pro Arg Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Leu Lys Arg 
                245 


<210>  38
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD21-binding domain

<400>  38

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          


Phe Met His Trp Ile Lys Gln Gln Pro Gly Asn Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Ser Pro Gly Asp Gly Asp Thr Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Asn Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Asp Ser Ser Gly Trp Gly Pro Asn Trp Phe Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  39
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD21-binding domain

<400>  39

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Val Thr Ile Thr Cys Leu Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Met Ile 
        35                  40                  45              


Tyr Asp Val Asn Asn Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asn His Ser Leu Thr Ile Asn Ser Leu Gly Tyr 
65                  70                  75                  80  


Asp Asp Glu Gly Ile Tyr His Cys Gln Gln Tyr Tyr Glu Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  40
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD21-binding domain

<400>  40

Glu Val His Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          


Phe Met His Trp Ile Lys Gln Gln Pro Gly Asn Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Asp Thr Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Asn Gly Lys Ala Ser Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Leu Ser Gly Asp Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Val Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  41
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD21-binding domain

<400>  41

Glu Ile Val Leu Thr Gln Ser Pro Thr Thr Met Thr Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Val Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Asp Ala Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Glu Thr Ser Lys Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Asn Asn Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Phe Pro Leu Thr Phe 
                85                  90                  95      


Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105     


<210>  42
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD21-binding domain

<400>  42

Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ser Ser 
1               5                   10                  15      


Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Asn Phe 
            20                  25                  30          


Met His Trp Ile Lys Gln Gln Pro Gly Asn Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Trp Ile Asn Pro Gly Asp Gly Asn Thr Glu Tyr Asn Gln Lys Phe Asn 
    50                  55                  60                  


Val Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Gly Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Asp Tyr Ser Gly Trp Gly Pro Asn Trp Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  43
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD21-binding domain

<400>  43

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Glu Cys Arg Ala Ser Glu Asp Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


His Asp Ala Asn Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Val Ala Ser Tyr Phe Cys Gln Gln Tyr Asn Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  44
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD21-binding domain

<400>  44

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Asn 
            20                  25                  30          


Phe Met His Trp Ile Lys Gln Gln Pro Gly Asn Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Pro Gly Asp Gly Asn Thr Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Asn Val Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Gly Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Ser Gly Trp Gly Pro Asn Trp Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  45
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD21-binding domain

<400>  45

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Val Thr Ile Thr Cys Leu Ala Ser Gln Asp Ile Gly Asp Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Val Met Val 
        35                  40                  45              


Tyr Gly Ala Thr Asn Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Asn Ser Leu Gly Tyr 
65                  70                  75                  80  


Asp Asp Glu Gly Ile Tyr His Cys His Gln Tyr Tyr Gln Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  46
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD21-binding domain

<400>  46

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Gly Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Val Ser Gly Tyr Asn Ile Arg Asn Thr 
            20                  25                  30          


Tyr Ile His Trp Val Asn Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asp Thr Ile Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Gln Leu Lys Ser Asp Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Met Arg Met Val Gly Thr Gly Gly Tyr Ala Met Asp Ala Trp Gly 
            100                 105                 110         


Gln Gly Ala Ser Val Thr Val Ser Ser 
        115                 120     


<210>  47
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD21-binding domain

<400>  47

Asp Ile Val Leu Thr Gln Ser Pro Ala Leu Ala Val Ser Pro Gly Gln 
1               5                   10                  15      


Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Ile Ser Ser 
            20                  25                  30          


Val Asn Leu Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Gln Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr His Ala Ser Asn Leu Ala Ser Gly Ile Pro Thr Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Pro 
65                  70                  75                  80  


Val Gln Ala Asp Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Glu 
                85                  90                  95      


Ser Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105                 110     


<210>  48
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD21-binding domain

<400>  48

Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Glu Pro Gly Ser Ser 
1               5                   10                  15      


Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asn Phe 
            20                  25                  30          


Met His Trp Ile Arg Gln Gln Pro Gly Asn Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Trp Val Tyr Arg Gly Asp Gly Asp Thr Glu Tyr Asn Gln Arg Phe Asn 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Ile 
65                  70                  75                  80  


Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Asp Ser Ser Gly Trp Gly Pro Asn Trp Phe Asp Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  49
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD21-binding domain

<400>  49

Asp Val Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Glu Cys Arg Ala Ser Glu Asp Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Asn Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Val Ala Ser Tyr Phe Cys Gln Gln Tyr Asn Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Glu Thr Arg Leu Glu Ile Lys Arg 
            100                 105             


<210>  50
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD21-binding domain

<400>  50

Gln Val Gln Leu Gln Gln Ser Gly Ala Gln Leu Val Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Phe Thr Phe Ser Ser Ser 
            20                  25                  30          


Tyr Ile Ser Trp Leu Lys Gln Ala Pro Gly Gln Ser Phe Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Phe Ala Gly Asp Gly Gly Pro Asn Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Leu Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro Trp Ala Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  51
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD21-binding domain

<400>  51

Glu Ile Val Leu Thr Gln Ser Pro Thr Thr Thr Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Leu Ala Ser Ser Ser Ala Ser Asn Met 
            20                  25                  30          


Phe Trp Tyr Gln Gln Lys Ser Gly Asp Ser Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ser Thr Ser Ser Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Leu Gln Arg Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105         


<210>  52
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD21-binding domain

<400>  52

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Lys 
1               5                   10                  15      


Ser Leu Lys Leu Thr Cys Ala Thr Ser Gly Phe Thr Phe Ser Thr Ala 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ser Pro Asp Lys Arg Leu Glu Trp Ile 
        35                  40                  45              


Ala Arg Ile Lys Asp Lys Ser Lys Asn Tyr Ala Thr Asp Tyr Val Glu 
    50                  55                  60                  


Ala Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Glu Glu Asp Thr Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Gly Thr Tyr Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Val Met Val Thr Val Ser Ser 
        115                 120 


<210>  53
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD21-binding domain

<400>  53

Glu Ile Val Leu Thr Gln Ser Pro Thr Thr Thr Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Leu Ala Asn Ser Ser Val Ser Asn Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Gly Ala Ser Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ser Thr Ser Arg Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Ser Ser Leu Thr Ile Asn Thr Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asp Pro Pro Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105         


<210>  54
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD21-binding domain

<400>  54

Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ser Ser 
1               5                   10                  15      


Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr His 
            20                  25                  30          


Ile Thr Trp Ile Lys Gln Thr Thr Gly Gln Gly Leu Glu Tyr Val Gly 
        35                  40                  45              


Tyr Ile Asn Thr Gly Ser Gly Thr Thr Tyr Tyr Asn Glu Lys Phe Lys 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Phe Met 
65                  70                  75                  80  


Gln Leu Ser Ser Leu Thr Pro Asp Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Leu Val Leu His Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  55
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD21-binding domain

<400>  55

Asp Ile Val Met Thr Gln Gly Ala Leu Pro Asn Pro Val Pro Ser Gly 
1               5                   10                  15      


Glu Val Ala Ser Ile Thr Cys Gln Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Asn Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Trp Met Ser Thr Arg Ala Ser Gly Val Ser 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Ser Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln Phe 
                85                  90                  95      


Leu Glu Tyr Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Arg 
    


<210>  56
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker sequence

<400>  56

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  57
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clone MP28132 VL CDR2

<400>  57

Asp Ala Asn Ser Leu Ala Asp 
1               5           


<210>  58
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv sequence

<400>  58

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          


Phe Met His Trp Ile Lys Gln Gln Pro Gly Asn Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Ser Pro Gly Asp Gly Asp Thr Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Asn Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Asp Ser Ser Gly Trp Gly Pro Asn Trp Phe Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Met Ser Ala Ser Leu Gly Asp Thr Val Thr Ile Thr Cys 
145                 150                 155                 160 


Leu Ala Ser Gln Asp Ile Gly Asn Tyr Leu Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ser Pro Lys Leu Met Ile Tyr Asp Val Asn Asn Leu Glu 
            180                 185                 190         


Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Ser Asn His 
        195                 200                 205             


Ser Leu Thr Ile Asn Ser Leu Gly Tyr Asp Asp Glu Gly Ile Tyr His 
    210                 215                 220                 


Cys Gln Gln Tyr Tyr Glu Tyr Pro Leu Thr Phe Gly Ser Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys Arg 
                245 


<210>  59
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  transmembrane domain

<400>  59

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  60
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3-zeta endodomain

<400>  60

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  61
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB and CD3-zeta endodomains

<400>  61

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
                245                 250                 255     


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
            260                 265                 270         


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
        275                 280                 285             


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
    290                 295                 300                 


Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
305                 310                 315                 320 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                325                 330                 335     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            340                 345                 350         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 365             


<210>  62
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 and CD3-zeta endodomains

<400>  62

Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
1               5                   10                  15      


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
            20                  25                  30          


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala 
        35                  40                  45              


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
    50                  55                  60                  


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
65                  70                  75                  80  


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
                85                  90                  95      


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
            100                 105                 110         


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
        115                 120                 125             


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
    130                 135                 140                 


His Met Gln Ala Leu Pro Pro Arg 
145                 150         


<210>  63
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28, OX40 and CD3-zeta endodomains

<400>  63

Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
1               5                   10                  15      


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
            20                  25                  30          


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Asp Gln Arg Leu Pro Pro Asp 
        35                  40                  45              


Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu 
    50                  55                  60                  


Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Arg Val Lys Phe 
65                  70                  75                  80  


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
                85                  90                  95      


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            100                 105                 110         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        115                 120                 125             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    130                 135                 140                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
145                 150                 155                 160 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                165                 170                 175     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            180                 185             


<210>  64
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITAM (immunoreceptor tyrosine-based activation motif)


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa may be Leu or Ile

<400>  64

Tyr Xaa Xaa Xaa 
1               


