                         SEQUENCE LISTING

<110>  University of Massachusetts
 
<120>  RAAV VECTORS ENCODING OF LYSOSOMAL BETA-GALACTOSIDASE (GLB1) AND 
       CATHEPSIN A

<130>  U0120.70107WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 62/672,004
<151>  2018-05-15

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  2034
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  1
atgccggggt tcctggttcg catcctcctt ctgctgctgg ttctgctgct tctgggccct       60

acgcgcggct tgcgcaatgc cacccagagg atgtttgaaa ttgactatag ccgggactcc      120

ttcctcaagg atggccagcc atttcgctac atctcaggaa gcattcacta ctcccgtgtg      180

ccccgcttct actggaagga ccggctgctg aagatgaaga tggctgggct gaacgccatc      240

cagacgtatg tgccctggaa ctttcatgag ccctggccag gacagtacca gttttctgag      300

gaccatgatg tggaatattt tcttcggctg gctcatgagc tgggactgct ggttatcctg      360

aggcccgggc cctacatctg tgcagagtgg gaaatgggag gattacctgc ttggctgcta      420

gagaaagagt ctattcttct ccgctcctcc gacccagatt acctggcagc tgtggacaag      480

tggttgggag tccttctgcc caagatgaag cctctcctct atcagaatgg agggccagtt      540

ataacagtgc aggttgaaaa tgaatatggc agctactttg cctgtgattt tgactacctg      600

cgcttcctgc agaagcgctt tcgccaccat ctgggggatg atgtggttct gtttaccact      660

gatggagcac ataaaacatt cctgaaatgt ggggccctgc agggcctcta caccacggtg      720

gactttggaa caggcagcaa catcacagat gctttcctaa gccagaggaa gtgtgagccc      780

aaaggaccct tgatcaattc tgaattctat actggctggc tagatcactg gggccaacct      840

cactccacaa tcaagaccga agcagtggct tcctccctct atgatatact tgcccgtggg      900

gcgagtgtga acttgtacat gtttataggt gggaccaatt ttgcctattg gaatggggcc      960

aactcaccct atgcagcaca gcccaccagc tacgactatg atgccccact gagtgaggct     1020

ggggacctca ctgagaagta ttttgctctg cgaaacatca tccagaagtt tgaaaaagta     1080

ccagaaggtc ctatccctcc atctacacca aagtttgcat atggaaaggt cactttggaa     1140

aagttaaaga cagtgggagc agctctggac attctgtgtc cctctgggcc catcaaaagc     1200

ctttatccct tgacatttat ccaggtgaaa cagcattatg ggtttgtgct gtaccggaca     1260

acacttcctc aagattgcag caacccagca cctctctctt cacccctcaa tggagtccac     1320

gatcgagcat atgttgctgt ggatgggatc ccccagggag tccttgagcg aaacaatgtg     1380

atcactctga acataacagg gaaagctgga gccactctgg accttctggt agagaacatg     1440

ggacgtgtga actatggtgc atatatcaac gattttaagg gtttggtttc taacctgact     1500

ctcagttcca atatcctcac ggactggacg atctttccac tggacactga ggatgcagtg     1560

cgcagccacc tggggggctg gggacaccgt gacagtggcc accatgatga agcctgggcc     1620

cacaactcat ccaactacac gctcccggcc ttttatatgg ggaacttctc cattcccagt     1680

gggatcccag acttgcccca ggacaccttt atccagtttc ctggatggac caagggccag     1740

gtctggatta atggctttaa ccttggccgc tattggccag cccggggccc tcagttgacc     1800

ttgtttgtgc cccagcacat cctgatgacc tcggccccaa acaccatcac cgtgctggaa     1860

ctggagtggg caccctgcag cagtgatgat ccagaactat gtgctgtgac gttcgtggac     1920

aggccagtta ttggctcatc tgtgacctac gatcatccct ccaaacctgt tgaaaaaaga     1980

ctcatgcccc cacccccgca aaaaaacaaa gattcatggc tggaccatgt atga           2034


<210>  2
<211>  1944
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  2
atgctccggg tccccctgtg tacgccgctc ccgctcctgg cactgctgca actgctgggc       60

gctgcgcacg gcatctataa tgtcacccag aggacattta agctcgacta cagccgggac      120

cgcttcctca aggatggaca gccattccga tacatctcgg gaagcattca ttacttccgg      180

ataccccgct tctactggga ggaccggctg ctgaagatga agatggctgg gctgaatgct      240

atccagatgt acgtgccctg gaacttccat gaaccccaac caggacaata tgagttttct      300

ggggaccgtg atgtggagca tttcatccag ctggctcatg agctgggact cctggtgatc      360

ctgaggcctg ggccctacat ctgtgcagag tgggacatgg ggggcttacc tgcttggcta      420

ctagagaaac aatctatcgt tctccggtct tctgacccag actaccttgt agctgtggat      480

aaatggctgg cagtccttct gcccaagatg aagcccctgc tctaccagaa cggaggaccg      540

atcataaccg tgcaggttga gaatgagtac gggtcctact ttgcctgcga ttacgactac      600

ctacgcttcc tggtgcaccg cttccgctac catctgggta atgacgtcat tctcttcacc      660

accgacggag caagtgaaaa aatgctgaag tgtgggaccc tgcaggacct gtacgccaca      720

gtggattttg gaacaggcaa caatatcaca caagctttcc tggtccagag gaagtttgaa      780

cctaaaggac ctttgatcaa ttctgagttc tatactggct ggctagacca ctggggtaaa      840

ccccattcca cggtgaaaac taaaacactg gctacctccc tctataacct gcttgcccgt      900

ggggccaacg tgaacttgta catgtttata ggtgggacca attttgccta ttggaatggt      960

gccaacacgc cctatgagcc acagcccacc agctatgact acgacgcccc actgagcgag     1020

gctggggacc tcactaagaa gtattttgct cttcgagaag tcattcagat gtttaaagaa     1080

gtcccagaag gccctatccc tccgtctaca cccaaatttg catatggaaa agttgctctg     1140

agaaagttca agacagtggc tgaagctctg ggtatcctgt gtcccaatgg gccagtgaaa     1200

agcctctatc ccctgacatt cactcaggta aaacagtatt ttgggtatgt gctgtaccga     1260

acaacgcttc ctcaagattg cagtaacccg aaacccattt tctcttcacc cttcaatggt     1320

gtccgtgatc gggcttacgt ctctgtggac ggggtccccc aaggaatcct tgatcgaaac     1380

ctcatgacag ctctgaacat acgggggaag gctggagcca cgctggacat cctggtggag     1440

aacatggggc gtgtgaacta tggcagattc atcaatgact tcaagggttt gatttccaac     1500

atgactatca actccactgt cctcaccaac tggacggtct tcccactgaa cactgaggcc     1560

atggtacgca accatctctg gggccgggag gccagtgatg agggtcacct tgacggacgg     1620

tcgacctcca attcttcgga cctcatactc cccacctttt acgtgggcaa cttctccatc     1680

ccctcgggca tcccagacct gccacaggac accttcatcc agtttcctgg gtggtccaag     1740

ggtcaagtat ggatcaatgg ctttaacctc ggccgatact ggcccacaat gggcccacaa     1800

aagaccttgt tcgtgccaag gaacatcctg accacttcag ccccaaacaa catcacagtg     1860

ttggagctag agtttgcacc ctgcagcgag gggaccccag agctgtgtac agtagagttt     1920

gttgacactc cggtcatttc ctga                                            1944


<210>  3
<211>  1497
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  3
atgacttcca gtccccgggc gcctcctgga gagcaaggac gcgggggagc agagatgatc       60

cgagcagcgc ctccaccact gttcttgttg ctgctcctgt tgctgttgct agtgtcctgg      120

gcgtcccgag gcgaggcagc ccccgaccag gacgagatcc agcgcctccc cgggctggcc      180

aagcagccgt ctttccgcca gtactccggc tacctcaaag gctccggctc caagcacctc      240

cactactggt ttgtggagtc ccagaaggat cccgagaaca gccctgtggt gctttggctc      300

aatgggggtc ccggctgcag ctcactagat gggctcctca cagagcatgg ccccttcctg      360

gtccagccag atggtgtcac cctggagtac aacccctatt cttggaatct gattgccaat      420

gtgttatacc tggagtcccc agctggggtg ggcttctcct actccgatga caagttttat      480

gcaactaatg acactgaggt cgcccagagc aattttgagg cccttcaaga tttcttccgc      540

ctctttccgg agtacaagaa caacaaactt ttcctgaccg gggagagcta tgctggcatc      600

tacatcccca ccctggccgt gctggtcatg caggatccca gcatgaacct tcaggggctg      660

gctgtgggca atggactctc ctcctatgag cagaatgaca actccctggt ctactttgcc      720

tactaccatg gccttctggg gaacaggctt tggtcttctc tccagaccca ctgctgctct      780

caaaacaagt gtaacttcta tgacaacaaa gacctggaat gcgtgaccaa tcttcaggaa      840

gtggcccgca tcgtgggcaa ctctggcctc aacatctaca atctctatgc cccgtgtgct      900

ggaggggtgc ccagccattt taggtatgag aaggacactg ttgtggtcca ggatttgggc      960

aacatcttca ctcgcctgcc actcaagcgg atgtggcatc aggcactgct gcgctcaggg     1020

gataaagtgc gcatggaccc cccctgcacc aacacaacag ctgcttccac ctacctcaac     1080

aacccgtacg tgcggaaggc cctcaacatc ccggagcagc tgccacaatg ggacatgtgc     1140

aactttctgg taaacttaca gtaccgccgt ctctaccgaa gcatgaactc ccagtatctg     1200

aagctgctta gctcacagaa ataccagatc ctattatata atggagatgt agacatggcc     1260

tgcaatttca tgggggatga gtggtttgtg gattccctca accagaagat ggaggtgcag     1320

cgccggccct ggttagtgaa gtacggggac agcggggagc agattgccgg cttcgtgaag     1380

gagttctccc acatcgcctt tctcacgatc aagggcgccg gccacatggt tcccaccgac     1440

aagcccctcg ctgccttcac catgttctcc cgcttcctga acaagcagcc atactga        1497


<210>  4
<211>  1479
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  4
atgacttcca gtccaaaggc gcctcctgga gagcaaggac gcaaggaagc agagatgccc       60

ggaaccgcgc tgtctccact gctcttgttg ctgctcctgt cctgggcgtc ccggaacgaa      120

gcagctccgg accaggatga aatcgattgt ctccccggcc tggccaagca gccctctttc      180

cggcaatact ccggctacct cagagcatcg gactccaagc acttccacta ctggtttgtg      240

gagtcgcaga acgacccaaa gaacagcccc gtggtgcttt ggcttaacgg gggtcccggc      300

tgcagctcgc tcgatgggct gcttacagag cacggcccct ttctgatcca gccagatggt      360

gtcaccctgg agtacaaccc ctatgcttgg aacctgattg ccaacgtgct gtatatcgag      420

tccccagctg gggtgggctt ctcctactcg gatgacaaga tgtacgtgac caatgacaca      480

gaggtggcgg agaacaatta tgaagccctt aaagacttct tccgcctctt tccggaatac      540

aaggacaaca aacttttcct gacaggagag agctatgctg gcatctacat ccccaccttg      600

gctgtactgg tcatgcagga tcctagcatg aatcttcagg ggctggctgt gggcaatgga      660

cttgcctcct atgagcagaa cgacaactcc ctggtctact ttgcctacta ccatggcctt      720

ctggggaaca gactttggac ttcactgcag acccactgct gcgctcagaa caagtgtaac      780

ttctatgaca acaaagaccc agagtgtgta aacaatctcc tggaagtgtc tcgaattgtg      840

ggcaaatctg gcctcaacat ctacaatctc tatgctccgt gtgctggtgg ggtgcccggc      900

agacatagat atgaggacac acttgtagtc caggattttg gcaacatctt cactcgcctg      960

ccacttaagc ggagatttcc tgaggcactg atgcgttctg gggacaaggt acgcttggat     1020

cctccctgca ccaacaccac agccccttcc aactacctca acaaccccta tgttcggaag     1080

gctctccaca tccccgagtc gctgccccgc tgggacatgt gcaacttctt ggtgaattta     1140

cagtaccgcc gcctctacca aagcatgaac tcccagtacc tgaagctgct cagttcacag     1200

aaataccaga tcctgctcta caacggagat gtggacatgg cctgcaactt catgggcgat     1260

gagtggtttg tggattcgct caaccagaag atggaggtgc agcgccggcc ctggctagtg     1320

gactacgggg agagcggaga acaggtagct ggtttcgtga aggagtgttc acacatcacc     1380

ttcctcacca tcaagggtgc cggacacatg gtccccacgg acaagcctcg agctgctttt     1440

accatgttct cgaggttcct gaacaaagag ccttactga                            1479


<210>  5
<211>  677
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Pro Gly Phe Leu Val Arg Ile Leu Pro Leu Leu Leu Val Leu Leu 
1               5                   10                  15      


Leu Leu Gly Pro Thr Arg Gly Leu Arg Asn Ala Thr Gln Arg Met Phe 
            20                  25                  30          


Glu Ile Asp Tyr Ser Arg Asp Ser Phe Leu Lys Asp Gly Gln Pro Phe 
        35                  40                  45              


Arg Tyr Ile Ser Gly Ser Ile His Tyr Ser Arg Val Pro Arg Phe Tyr 
    50                  55                  60                  


Trp Lys Asp Arg Leu Leu Lys Met Lys Met Ala Gly Leu Asn Ala Ile 
65                  70                  75                  80  


Gln Thr Tyr Val Pro Trp Asn Phe His Glu Pro Trp Pro Gly Gln Tyr 
                85                  90                  95      


Gln Phe Ser Glu Asp His Asp Val Glu Tyr Phe Leu Arg Leu Ala His 
            100                 105                 110         


Glu Leu Gly Leu Leu Val Ile Leu Arg Pro Gly Pro Tyr Ile Cys Ala 
        115                 120                 125             


Glu Trp Glu Met Gly Gly Leu Pro Ala Trp Leu Leu Glu Lys Glu Ser 
    130                 135                 140                 


Ile Leu Leu Arg Ser Ser Asp Pro Asp Tyr Leu Ala Ala Val Asp Lys 
145                 150                 155                 160 


Trp Leu Gly Val Leu Leu Pro Lys Met Lys Pro Leu Leu Tyr Gln Asn 
                165                 170                 175     


Gly Gly Pro Val Ile Thr Val Gln Val Glu Asn Glu Tyr Gly Ser Tyr 
            180                 185                 190         


Phe Ala Cys Asp Phe Asp Tyr Leu Arg Phe Leu Gln Lys Arg Phe Arg 
        195                 200                 205             


His His Leu Gly Asp Asp Val Val Leu Phe Thr Thr Asp Gly Ala His 
    210                 215                 220                 


Lys Thr Phe Leu Lys Cys Gly Ala Leu Gln Gly Leu Tyr Thr Thr Val 
225                 230                 235                 240 


Asp Phe Gly Thr Gly Ser Asn Ile Thr Asp Ala Phe Leu Ser Gln Arg 
                245                 250                 255     


Lys Cys Glu Pro Lys Gly Pro Leu Ile Asn Ser Glu Phe Tyr Thr Gly 
            260                 265                 270         


Trp Leu Asp His Trp Gly Gln Pro His Ser Thr Ile Lys Thr Glu Ala 
        275                 280                 285             


Val Ala Ser Ser Leu Tyr Asp Ile Leu Ala Arg Gly Ala Ser Val Asn 
    290                 295                 300                 


Leu Tyr Met Phe Ile Gly Gly Thr Asn Phe Ala Tyr Trp Asn Gly Ala 
305                 310                 315                 320 


Asn Ser Pro Tyr Ala Ala Gln Pro Thr Ser Tyr Asp Tyr Asp Ala Pro 
                325                 330                 335     


Leu Ser Glu Ala Gly Asp Leu Thr Glu Lys Tyr Phe Ala Leu Arg Asn 
            340                 345                 350         


Ile Ile Gln Lys Phe Glu Lys Val Pro Glu Gly Pro Ile Pro Pro Ser 
        355                 360                 365             


Thr Pro Lys Phe Ala Tyr Gly Lys Val Thr Leu Glu Lys Leu Lys Thr 
    370                 375                 380                 


Val Gly Ala Ala Leu Asp Ile Leu Cys Pro Ser Gly Pro Ile Lys Ser 
385                 390                 395                 400 


Leu Tyr Pro Leu Thr Phe Ile Gln Val Lys Gln His Tyr Gly Phe Val 
                405                 410                 415     


Leu Tyr Arg Thr Thr Leu Pro Gln Asp Cys Ser Asn Pro Ala Pro Leu 
            420                 425                 430         


Ser Ser Pro Leu Asn Gly Val His Asp Arg Ala Tyr Val Ala Val Asp 
        435                 440                 445             


Gly Ile Pro Gln Gly Val Leu Glu Arg Asn Asn Val Ile Thr Leu Asn 
    450                 455                 460                 


Ile Thr Gly Lys Ala Gly Ala Thr Leu Asp Leu Leu Val Glu Asn Met 
465                 470                 475                 480 


Gly Arg Val Asn Tyr Gly Ala Tyr Ile Asn Asp Phe Lys Gly Leu Val 
                485                 490                 495     


Ser Asn Leu Thr Leu Ser Ser Asn Ile Leu Thr Asp Trp Thr Ile Phe 
            500                 505                 510         


Pro Leu Asp Thr Glu Asp Ala Val Arg Ser His Leu Gly Gly Trp Gly 
        515                 520                 525             


His Arg Asp Ser Gly His His Asp Glu Ala Trp Ala His Asn Ser Ser 
    530                 535                 540                 


Asn Tyr Thr Leu Pro Ala Phe Tyr Met Gly Asn Phe Ser Ile Pro Ser 
545                 550                 555                 560 


Gly Ile Pro Asp Leu Pro Gln Asp Thr Phe Ile Gln Phe Pro Gly Trp 
                565                 570                 575     


Thr Lys Gly Gln Val Trp Ile Asn Gly Phe Asn Leu Gly Arg Tyr Trp 
            580                 585                 590         


Pro Ala Arg Gly Pro Gln Leu Thr Leu Phe Val Pro Gln His Ile Leu 
        595                 600                 605             


Met Thr Ser Ala Pro Asn Thr Ile Thr Val Leu Glu Leu Glu Trp Ala 
    610                 615                 620                 


Pro Cys Ser Ser Asp Asp Pro Glu Leu Cys Ala Val Thr Phe Val Asp 
625                 630                 635                 640 


Arg Pro Val Ile Gly Ser Ser Val Thr Tyr Asp His Pro Ser Lys Pro 
                645                 650                 655     


Val Glu Lys Arg Leu Met Pro Pro Pro Pro Gln Lys Asn Lys Asp Ser 
            660                 665                 670         


Trp Leu Asp His Val 
        675         


<210>  6
<211>  647
<212>  PRT
<213>  Mus musculus

<400>  6

Met Leu Arg Val Pro Leu Cys Thr Pro Leu Pro Leu Leu Ala Leu Leu 
1               5                   10                  15      


Gln Leu Leu Gly Ala Ala His Gly Ile Tyr Asn Val Thr Gln Arg Thr 
            20                  25                  30          


Phe Lys Leu Asp Tyr Ser Arg Asp Arg Phe Leu Lys Asp Gly Gln Pro 
        35                  40                  45              


Phe Arg Tyr Ile Ser Gly Ser Ile His Tyr Phe Arg Ile Pro Arg Phe 
    50                  55                  60                  


Tyr Trp Glu Asp Arg Leu Leu Lys Met Lys Met Ala Gly Leu Asn Ala 
65                  70                  75                  80  


Ile Gln Met Tyr Val Pro Trp Asn Phe His Glu Pro Gln Pro Gly Gln 
                85                  90                  95      


Tyr Glu Phe Ser Gly Asp Arg Asp Val Glu His Phe Ile Gln Leu Ala 
            100                 105                 110         


His Glu Leu Gly Leu Leu Val Ile Leu Arg Pro Gly Pro Tyr Ile Cys 
        115                 120                 125             


Ala Glu Trp Asp Met Gly Gly Leu Pro Ala Trp Leu Leu Glu Lys Gln 
    130                 135                 140                 


Ser Ile Val Leu Arg Ser Ser Asp Pro Asp Tyr Leu Val Ala Val Asp 
145                 150                 155                 160 


Lys Trp Leu Ala Val Leu Leu Pro Lys Met Lys Pro Leu Leu Tyr Gln 
                165                 170                 175     


Asn Gly Gly Pro Ile Ile Thr Val Gln Val Glu Asn Glu Tyr Gly Ser 
            180                 185                 190         


Tyr Phe Ala Cys Asp Tyr Asp Tyr Leu Arg Phe Leu Val His Arg Phe 
        195                 200                 205             


Arg Tyr His Leu Gly Asn Asp Val Ile Leu Phe Thr Thr Asp Gly Ala 
    210                 215                 220                 


Ser Glu Lys Met Leu Lys Cys Gly Thr Leu Gln Asp Leu Tyr Ala Thr 
225                 230                 235                 240 


Val Asp Phe Gly Thr Gly Asn Asn Ile Thr Gln Ala Phe Leu Val Gln 
                245                 250                 255     


Arg Lys Phe Glu Pro Lys Gly Pro Leu Ile Asn Ser Glu Phe Tyr Thr 
            260                 265                 270         


Gly Trp Leu Asp His Trp Gly Lys Pro His Ser Thr Val Lys Thr Lys 
        275                 280                 285             


Thr Leu Ala Thr Ser Leu Tyr Asn Leu Leu Ala Arg Gly Ala Asn Val 
    290                 295                 300                 


Asn Leu Tyr Met Phe Ile Gly Gly Thr Asn Phe Ala Tyr Trp Asn Gly 
305                 310                 315                 320 


Ala Asn Thr Pro Tyr Glu Pro Gln Pro Thr Ser Tyr Asp Tyr Asp Ala 
                325                 330                 335     


Pro Leu Ser Glu Ala Gly Asp Leu Thr Lys Lys Tyr Phe Ala Leu Arg 
            340                 345                 350         


Glu Val Ile Gln Met Phe Lys Glu Val Pro Glu Gly Pro Ile Pro Pro 
        355                 360                 365             


Ser Thr Pro Lys Phe Ala Tyr Gly Lys Val Ala Leu Arg Lys Phe Lys 
    370                 375                 380                 


Thr Val Ala Glu Ala Leu Gly Ile Leu Cys Pro Asn Gly Pro Val Lys 
385                 390                 395                 400 


Ser Leu Tyr Pro Leu Thr Phe Thr Gln Val Lys Gln Tyr Phe Gly Tyr 
                405                 410                 415     


Val Leu Tyr Arg Thr Thr Leu Pro Gln Asp Cys Ser Asn Pro Lys Pro 
            420                 425                 430         


Ile Phe Ser Ser Pro Phe Asn Gly Val Arg Asp Arg Ala Tyr Val Ser 
        435                 440                 445             


Val Asp Gly Val Pro Gln Gly Ile Leu Asp Arg Asn Leu Met Thr Ala 
    450                 455                 460                 


Leu Asn Ile Arg Gly Lys Ala Gly Ala Thr Leu Asp Ile Leu Val Glu 
465                 470                 475                 480 


Asn Met Gly Arg Val Asn Tyr Gly Arg Phe Ile Asn Asp Phe Lys Gly 
                485                 490                 495     


Leu Ile Ser Asn Met Thr Ile Asn Ser Thr Val Leu Thr Asn Trp Thr 
            500                 505                 510         


Val Phe Pro Leu Asn Thr Glu Ala Met Val Arg Asn His Leu Trp Gly 
        515                 520                 525             


Arg Glu Ala Ser Asp Glu Gly His Leu Asp Gly Arg Ser Thr Ser Asn 
    530                 535                 540                 


Ser Ser Asp Leu Ile Leu Pro Thr Phe Tyr Val Gly Asn Phe Ser Ile 
545                 550                 555                 560 


Pro Ser Gly Ile Pro Asp Leu Pro Gln Asp Thr Phe Ile Gln Phe Pro 
                565                 570                 575     


Gly Trp Ser Lys Gly Gln Val Trp Ile Asn Gly Phe Asn Leu Gly Arg 
            580                 585                 590         


Tyr Trp Pro Thr Met Gly Pro Gln Lys Thr Leu Phe Val Pro Arg Asn 
        595                 600                 605             


Ile Leu Thr Thr Ser Ala Pro Asn Asn Ile Thr Val Leu Glu Leu Glu 
    610                 615                 620                 


Phe Ala Pro Cys Ser Glu Gly Thr Pro Glu Leu Cys Thr Val Glu Phe 
625                 630                 635                 640 


Val Asp Thr Pro Val Ile Ser 
                645         


<210>  7
<211>  498
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Thr Ser Ser Pro Arg Ala Pro Pro Gly Glu Gln Gly Arg Gly Gly 
1               5                   10                  15      


Ala Glu Met Ile Arg Ala Ala Pro Pro Pro Leu Phe Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Leu Val Ser Trp Ala Ser Arg Gly Glu Ala Ala Pro 
        35                  40                  45              


Asp Gln Asp Glu Ile Gln Arg Leu Pro Gly Leu Ala Lys Gln Pro Ser 
    50                  55                  60                  


Phe Arg Gln Tyr Ser Gly Tyr Leu Lys Gly Ser Gly Ser Lys His Leu 
65                  70                  75                  80  


His Tyr Trp Phe Val Glu Ser Gln Lys Asp Pro Glu Asn Ser Pro Val 
                85                  90                  95      


Val Leu Trp Leu Asn Gly Gly Pro Gly Cys Ser Ser Leu Asp Gly Leu 
            100                 105                 110         


Leu Thr Glu His Gly Pro Phe Leu Val Gln Pro Asp Gly Val Thr Leu 
        115                 120                 125             


Glu Tyr Asn Pro Tyr Ser Trp Asn Leu Ile Ala Asn Val Leu Tyr Leu 
    130                 135                 140                 


Glu Ser Pro Ala Gly Val Gly Phe Ser Tyr Ser Asp Asp Lys Phe Tyr 
145                 150                 155                 160 


Ala Thr Asn Asp Thr Glu Val Ala Gln Ser Asn Phe Glu Ala Leu Gln 
                165                 170                 175     


Asp Phe Phe Arg Leu Phe Pro Glu Tyr Lys Asn Asn Lys Leu Phe Leu 
            180                 185                 190         


Thr Gly Glu Ser Tyr Ala Gly Ile Tyr Ile Pro Thr Leu Ala Val Leu 
        195                 200                 205             


Val Met Gln Asp Pro Ser Met Asn Leu Gln Gly Leu Ala Val Gly Asn 
    210                 215                 220                 


Gly Leu Ser Ser Tyr Glu Gln Asn Asp Asn Ser Leu Val Tyr Phe Ala 
225                 230                 235                 240 


Tyr Tyr His Gly Leu Leu Gly Asn Arg Leu Trp Ser Ser Leu Gln Thr 
                245                 250                 255     


His Cys Cys Ser Gln Asn Lys Cys Asn Phe Tyr Asp Asn Lys Asp Leu 
            260                 265                 270         


Glu Cys Val Thr Asn Leu Gln Glu Val Ala Arg Ile Val Gly Asn Ser 
        275                 280                 285             


Gly Leu Asn Ile Tyr Asn Leu Tyr Ala Pro Cys Ala Gly Gly Val Pro 
    290                 295                 300                 


Ser His Phe Arg Tyr Glu Lys Asp Thr Val Val Val Gln Asp Leu Gly 
305                 310                 315                 320 


Asn Ile Phe Thr Arg Leu Pro Leu Lys Arg Met Trp His Gln Ala Leu 
                325                 330                 335     


Leu Arg Ser Gly Asp Lys Val Arg Met Asp Pro Pro Cys Thr Asn Thr 
            340                 345                 350         


Thr Ala Ala Ser Thr Tyr Leu Asn Asn Pro Tyr Val Arg Lys Ala Leu 
        355                 360                 365             


Asn Ile Pro Glu Gln Leu Pro Gln Trp Asp Met Cys Asn Phe Leu Val 
    370                 375                 380                 


Asn Leu Gln Tyr Arg Arg Leu Tyr Arg Ser Met Asn Ser Gln Tyr Leu 
385                 390                 395                 400 


Lys Leu Leu Ser Ser Gln Lys Tyr Gln Ile Leu Leu Tyr Asn Gly Asp 
                405                 410                 415     


Val Asp Met Ala Cys Asn Phe Met Gly Asp Glu Trp Phe Val Asp Ser 
            420                 425                 430         


Leu Asn Gln Lys Met Glu Val Gln Arg Arg Pro Trp Leu Val Lys Tyr 
        435                 440                 445             


Gly Asp Ser Gly Glu Gln Ile Ala Gly Phe Val Lys Glu Phe Ser His 
    450                 455                 460                 


Ile Ala Phe Leu Thr Ile Lys Gly Ala Gly His Met Val Pro Thr Asp 
465                 470                 475                 480 


Lys Pro Leu Ala Ala Phe Thr Met Phe Ser Arg Phe Leu Asn Lys Gln 
                485                 490                 495     


Pro Tyr 
        


<210>  8
<211>  492
<212>  PRT
<213>  Mus musculus

<400>  8

Met Thr Ser Ser Pro Lys Ala Pro Pro Gly Glu Gln Gly Arg Lys Glu 
1               5                   10                  15      


Ala Glu Met Pro Gly Thr Ala Leu Ser Pro Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Ser Trp Ala Ser Arg Asn Glu Ala Ala Pro Asp Gln Asp Glu Ile 
        35                  40                  45              


Asp Cys Leu Pro Gly Leu Ala Lys Gln Pro Ser Phe Arg Gln Tyr Ser 
    50                  55                  60                  


Gly Tyr Leu Arg Ala Ser Asp Ser Lys His Phe His Tyr Trp Phe Val 
65                  70                  75                  80  


Glu Ser Gln Asn Asp Pro Lys Asn Ser Pro Val Val Leu Trp Leu Asn 
                85                  90                  95      


Gly Gly Pro Gly Cys Ser Ser Leu Asp Gly Leu Leu Thr Glu His Gly 
            100                 105                 110         


Pro Phe Leu Ile Gln Pro Asp Gly Val Thr Leu Glu Tyr Asn Pro Tyr 
        115                 120                 125             


Ala Trp Asn Leu Ile Ala Asn Val Leu Tyr Ile Glu Ser Pro Ala Gly 
    130                 135                 140                 


Val Gly Phe Ser Tyr Ser Asp Asp Lys Met Tyr Val Thr Asn Asp Thr 
145                 150                 155                 160 


Glu Val Ala Glu Asn Asn Tyr Glu Ala Leu Lys Asp Phe Phe Arg Leu 
                165                 170                 175     


Phe Pro Glu Tyr Lys Asp Asn Lys Leu Phe Leu Thr Gly Glu Ser Tyr 
            180                 185                 190         


Ala Gly Ile Tyr Ile Pro Thr Leu Ala Val Leu Val Met Gln Asp Pro 
        195                 200                 205             


Ser Met Asn Leu Gln Gly Leu Ala Val Gly Asn Gly Leu Ala Ser Tyr 
    210                 215                 220                 


Glu Gln Asn Asp Asn Ser Leu Val Tyr Phe Ala Tyr Tyr His Gly Leu 
225                 230                 235                 240 


Leu Gly Asn Arg Leu Trp Thr Ser Leu Gln Thr His Cys Cys Ala Gln 
                245                 250                 255     


Asn Lys Cys Asn Phe Tyr Asp Asn Lys Asp Pro Glu Cys Val Asn Asn 
            260                 265                 270         


Leu Leu Glu Val Ser Arg Ile Val Gly Lys Ser Gly Leu Asn Ile Tyr 
        275                 280                 285             


Asn Leu Tyr Ala Pro Cys Ala Gly Gly Val Pro Gly Arg His Arg Tyr 
    290                 295                 300                 


Glu Asp Thr Leu Val Val Gln Asp Phe Gly Asn Ile Phe Thr Arg Leu 
305                 310                 315                 320 


Pro Leu Lys Arg Arg Phe Pro Glu Ala Leu Met Arg Ser Gly Asp Lys 
                325                 330                 335     


Val Arg Leu Asp Pro Pro Cys Thr Asn Thr Thr Ala Pro Ser Asn Tyr 
            340                 345                 350         


Leu Asn Asn Pro Tyr Val Arg Lys Ala Leu His Ile Pro Glu Ser Leu 
        355                 360                 365             


Pro Arg Trp Asp Met Cys Asn Phe Leu Val Asn Leu Gln Tyr Arg Arg 
    370                 375                 380                 


Leu Tyr Gln Ser Met Asn Ser Gln Tyr Leu Lys Leu Leu Ser Ser Gln 
385                 390                 395                 400 


Lys Tyr Gln Ile Leu Leu Tyr Asn Gly Asp Val Asp Met Ala Cys Asn 
                405                 410                 415     


Phe Met Gly Asp Glu Trp Phe Val Asp Ser Leu Asn Gln Lys Met Glu 
            420                 425                 430         


Val Gln Arg Arg Pro Trp Leu Val Asp Tyr Gly Glu Ser Gly Glu Gln 
        435                 440                 445             


Val Ala Gly Phe Val Lys Glu Cys Ser His Ile Thr Phe Leu Thr Ile 
    450                 455                 460                 


Lys Gly Ala Gly His Met Val Pro Thr Asp Lys Pro Arg Ala Ala Phe 
465                 470                 475                 480 


Thr Met Phe Ser Arg Phe Leu Asn Lys Glu Pro Tyr 
                485                 490         


<210>  9
<211>  7071
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  9
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccaga tcttcaatat tggccattag ccatattatt      180

cattggttat atagcataaa tcaatattgg ctattggcca ttgcatacgt tgtatctata      240

tcataatatg tacatttata ttggctcatg tccaatatga ccgccatgtt ggcattgatt      300

attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga      360

gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg      420

cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg      480

acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca      540

tatgccaagt ccgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc      600

ccagtacatg accttacggg actttcctac ttggcagtac atctacgtat tagtcatcgc      660

tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct cccccccctc      720

cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga tgggggcggg      780

gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg gcggggcgag      840

gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc cttttatggc      900

gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg gagtcgctgc      960

gcgctgcctt cgccccgtgc cccgctccgc cgccgcctcg cgccgcccgc cccggctctg     1020

actgaccgcg ttactcccac aggtgagcgg gcgggacggc ccttctcctc cgggctgtaa     1080

ttagcgcttg gtttaatgac ggcttgtttc ttttctgtgg ctgcgtgaaa gccttgaggg     1140

gctccgggag ggccctttgt gcggggggag cggctcgggg ggtgcgtgcg tgtgtgtgtg     1200

cgtggggagc gccgcgtgcg gctccgcgct gcccggcggc tgtgagcgct gcgggcgcgg     1260

cgcggggctt tgtgcgctcc gcagtgtgcg cgaggggagc gcggccgggg gcggtgcccc     1320

gcggtgcggg gggggctgcg aggggaacaa aggctgcgtg cggggtgtgt gcgtgggggg     1380

gtgagcaggg ggtgtgggcg cgtcggtcgg gctgcaaccc cccctgcacc cccctccccg     1440

agttgctgag cacggcccgg cttcgggtgc ggggctccgt acggggcgtg gcgcggggct     1500

cgccgtgccg ggcggggggt ggcggcaggt gggggtgccg ggcggggcgg ggccgcctcg     1560

ggccggggag ggctcggggg aggggcgcgg cggcccccgg agcgccggcg gctgtcgagg     1620

cgcggcgagc cgcagccatt gccttttatg gtaatcgtgc gagagggcgc agggacttcc     1680

tttgtcccaa atctgtgcgg agccgaaatc tgggaggcgc cgccgcaccc cctctagcgg     1740

gcgcggggcg aagcggtgcg gcgccggcag gaaggaaatg ggcggggagg gccttcgtgc     1800

gtcgccgcgc cgccgtcccc ttctccctct ccagcctcgg ggctgtccgc ggggggacgg     1860

ctgccttcgg gggggacggg gcagggcggg gttcggcttc tggcgtgtga ccggcggctc     1920

tagagcctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc tgggcaacgt     1980

gctggttatt gtgctgtctc atcattttgg caaagaattc gatatcaagc ttgctagcgc     2040

caccatgccg gggttcctgg ttcgcatcct ccttctgctg ctggttctgc tgcttctggg     2100

ccctacgcgc ggcttgcgca atgccaccca gaggatgttt gaaattgact atagccggga     2160

ctccttcctc aaggatggcc agccatttcg ctacatctca ggaagcattc actactcccg     2220

tgtgccccgc ttctactgga aggaccggct gctgaagatg aagatggctg ggctgaacgc     2280

catccagacg tatgtgccct ggaactttca tgagccctgg ccaggacagt accagttttc     2340

tgaggaccat gatgtggaat attttcttcg gctggctcat gagctgggac tgctggttat     2400

cctgaggccc gggccctaca tctgtgcaga gtgggaaatg ggaggattac ctgcttggct     2460

gctagagaaa gagtctattc ttctccgctc ctccgaccca gattacctgg cagctgtgga     2520

caagtggttg ggagtccttc tgcccaagat gaagcctctc ctctatcaga atggagggcc     2580

agttataaca gtgcaggttg aaaatgaata tggcagctac tttgcctgtg attttgacta     2640

cctgcgcttc ctgcagaagc gctttcgcca ccatctgggg gatgatgtgg ttctgtttac     2700

cactgatgga gcacataaaa cattcctgaa atgtggggcc ctgcagggcc tctacaccac     2760

ggtggacttt ggaacaggca gcaacatcac agatgctttc ctaagccaga ggaagtgtga     2820

gcccaaagga cccttgatca attctgaatt ctatactggc tggctagatc actggggcca     2880

acctcactcc acaatcaaga ccgaagcagt ggcttcctcc ctctatgata tacttgcccg     2940

tggggcgagt gtgaacttgt acatgtttat aggtgggacc aattttgcct attggaatgg     3000

ggccaactca ccctatgcag cacagcccac cagctacgac tatgatgccc cactgagtga     3060

ggctggggac ctcactgaga agtattttgc tctgcgaaac atcatccaga agtttgaaaa     3120

agtaccagaa ggtcctatcc ctccatctac accaaagttt gcatatggaa aggtcacttt     3180

ggaaaagtta aagacagtgg gagcagctct ggacattctg tgtccctctg ggcccatcaa     3240

aagcctttat cccttgacat ttatccaggt gaaacagcat tatgggtttg tgctgtaccg     3300

gacaacactt cctcaagatt gcagcaaccc agcacctctc tcttcacccc tcaatggagt     3360

ccacgatcga gcatatgttg ctgtggatgg gatcccccag ggagtccttg agcgaaacaa     3420

tgtgatcact ctgaacataa cagggaaagc tggagccact ctggaccttc tggtagagaa     3480

catgggacgt gtgaactatg gtgcatatat caacgatttt aagggtttgg tttctaacct     3540

gactctcagt tccaatatcc tcacggactg gacgatcttt ccactggaca ctgaggatgc     3600

agtgcgcagc cacctggggg gctggggaca ccgtgacagt ggccaccatg atgaagcctg     3660

ggcccacaac tcatccaact acacgctccc ggccttttat atggggaact tctccattcc     3720

cagtgggatc ccagacttgc cccaggacac ctttatccag tttcctggat ggaccaaggg     3780

ccaggtctgg attaatggct ttaaccttgg ccgctattgg ccagcccggg gccctcagtt     3840

gaccttgttt gtgccccagc acatcctgat gacctcggcc ccaaacacca tcaccgtgct     3900

ggaactggag tgggcaccct gcagcagtga tgatccagaa ctatgtgctg tgacgttcgt     3960

ggacaggcca gttattggct catctgtgac ctacgatcat ccctccaaac ctgttgaaaa     4020

aagactcatg cccccacccc cgcaaaaaaa caaagattca tggctggacc atgtatgact     4080

cgagtttttt tttgcggccg cttcgagcag acatgataag atacattgat gagtttggac     4140

aaaccacaac tagaatgcag tgaaaaaaat gctttatttg tgaaatttgt gatgctattg     4200

ctttatttgt aaccattata agctgcaata aacaagttaa caacaacaat tgcattcatt     4260

ttatgtttca ggttcagggg gagatgtggg aggtttttta aagcaagtaa aacctctaca     4320

aatgtggtaa aatcgatagg ccgcaggaac ccctagtgat ggagttggcc actccctctc     4380

tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggcggcc     4440

tcagtgagcg agcgagcgcg cagctgcctg caggacatgt gagcaaaagg ccagcaaaag     4500

gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac     4560

gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga     4620

taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt     4680

accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca tagctcacgc     4740

tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc     4800

cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta     4860

agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat     4920

gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac tagaagaaca     4980

gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct     5040

tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt     5100

acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct     5160

cagtggaacg aaaactcacg ttaagggatt ttggtcatga gattatcaaa aaggatcttc     5220

acctagatcc ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa     5280

acttggtctg acagttacca atgcttaatc agtgaggcac ctatctcagc gatctgtcta     5340

tttcgttcat ccatagttgc ctgactcccc gtcgtgtaga taactacgat acgggagggc     5400

ttaccatctg gccccagtgc tgcaatgata ccgcgagacc cacgctcacc ggctccagat     5460

ttatcagcaa taaaccagcc agccggaagg gccgagcgca gaagtggtcc tgcaacttta     5520

tccgcctcca tccagtctat taattgttgc cgggaagcta gagtaagtag ttcgccagtt     5580

aatagtttgc gcaacgttgt tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt     5640

ggtatggctt cattcagctc cggttcccaa cgatcaaggc gagttacatg atcccccatg     5700

ttgtgcaaaa aagcggttag ctccttcggt cctccgatcg ttgtcagaag taagttggcc     5760

gcagtgttat cactcatggt tatggcagca ctgcataatt ctcttactgt catgccatcc     5820

gtaagatgct tttctgtgac tggtgagtac tcaaccaagt cattctgaga atagtgtatg     5880

cggcgaccga gttgctcttg cccggcgtca atacgggata ataccgcgcc acatagcaga     5940

actttaaaag tgctcatcat tggaaaacgt tcttcggggc gaaaactctc aaggatctta     6000

ccgctgttga gatccagttc gatgtaaccc actcgtgcac ccaactgatc ttcagcatct     6060

tttactttca ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag     6120

ggaataaggg cgacacggaa atgttgaata ctcatactct tcctttttca atattattga     6180

agcatttatc agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat     6240

aaacaaatag gggttccgcg cacatttccc cgaaaagtgc cacctgacgt ctaagaaacc     6300

attattatca tgacattaac ctataaaaat aggcgtatca cgaggccctt tcgtctcgcg     6360

cgtttcggtg atgacggtga aaacctctga cacatgcagc tcccggagac ggtcacagct     6420

tgtctgtaag cggatgccgg gagcagacaa gcccgtcagg gcgcgtcagc gggtgttggc     6480

gggtgtcggg gctggcttaa ctatgcggca tcagagcaga ttgtactgag agtgcaccat     6540

aaaattgtaa acgttaatat tttgttaaaa ttcgcgttaa atttttgtta aatcagctca     6600

ttttttaacc aatagaccga aatcggcaaa atcccttata aatcaaaaga atagcccgag     6660

atagagttga gtgttgttcc agtttggaac aagagtccac tattaaagaa cgtggactcc     6720

aacgtcaaag ggcgaaaaac cgtctatcag ggcgatggcc cactacgtga accatcaccc     6780

aaatcaagtt ttttggggtc gaggtgccgt aaagcactaa atcggaaccc taaagggagc     6840

ccccgattta gagcttgacg gggaaagccg gcgaacgtgg cgagaaagga agggaagaaa     6900

gcgaaaggag cgggcgctaa ggcgctggca agtgtagcgg tcacgctgcg cgtaaccacc     6960

acacccgccg cgcttaatgc gccgctacag ggcgcgtact atggttgctt tgacgtatgc     7020

ggtgtgaaat accgcacaga tgcgtaagga gaaaataccg catcaggcgc c              7071


<210>  10
<211>  6980
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  10
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccaga tcttcaatat tggccattag ccatattatt      180

cattggttat atagcataaa tcaatattgg ctattggcca ttgcatacgt tgtatctata      240

tcataatatg tacatttata ttggctcatg tccaatatga ccgccatgtt ggcattgatt      300

attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga      360

gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg      420

cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg      480

acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca      540

tatgccaagt ccgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc      600

ccagtacatg accttacggg actttcctac ttggcagtac atctacgtat tagtcatcgc      660

tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct cccccccctc      720

cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga tgggggcggg      780

gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg gcggggcgag      840

gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc cttttatggc      900

gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg gagtcgctgc      960

gcgctgcctt cgccccgtgc cccgctccgc cgccgcctcg cgccgcccgc cccggctctg     1020

actgaccgcg ttactcccac aggtgagcgg gcgggacggc ccttctcctc cgggctgtaa     1080

ttagcgcttg gtttaatgac ggcttgtttc ttttctgtgg ctgcgtgaaa gccttgaggg     1140

gctccgggag ggccctttgt gcggggggag cggctcgggg ggtgcgtgcg tgtgtgtgtg     1200

cgtggggagc gccgcgtgcg gctccgcgct gcccggcggc tgtgagcgct gcgggcgcgg     1260

cgcggggctt tgtgcgctcc gcagtgtgcg cgaggggagc gcggccgggg gcggtgcccc     1320

gcggtgcggg gggggctgcg aggggaacaa aggctgcgtg cggggtgtgt gcgtgggggg     1380

gtgagcaggg ggtgtgggcg cgtcggtcgg gctgcaaccc cccctgcacc cccctccccg     1440

agttgctgag cacggcccgg cttcgggtgc ggggctccgt acggggcgtg gcgcggggct     1500

cgccgtgccg ggcggggggt ggcggcaggt gggggtgccg ggcggggcgg ggccgcctcg     1560

ggccggggag ggctcggggg aggggcgcgg cggcccccgg agcgccggcg gctgtcgagg     1620

cgcggcgagc cgcagccatt gccttttatg gtaatcgtgc gagagggcgc agggacttcc     1680

tttgtcccaa atctgtgcgg agccgaaatc tgggaggcgc cgccgcaccc cctctagcgg     1740

gcgcggggcg aagcggtgcg gcgccggcag gaaggaaatg ggcggggagg gccttcgtgc     1800

gtcgccgcgc cgccgtcccc ttctccctct ccagcctcgg ggctgtccgc ggggggacgg     1860

ctgccttcgg gggggacggg gcagggcggg gttcggcttc tggcgtgtga ccggcggctc     1920

tagagcctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc tgggcaacgt     1980

gctggttatt gtgctgtctc atcattttgg caaagaattc gatatcaagc ttgctagccc     2040

accatgctcc gggtccccct gtgtacgccg ctcccgctcc tggcactgct gcaactgctg     2100

ggcgctgcgc acggcatcta taatgtcacc cagaggacat ttaagctcga ctacagccgg     2160

gaccgcttcc tcaaggatgg acagccattc cgatacatct cgggaagcat tcattacttc     2220

cggatacccc gcttctactg ggaggaccgg ctgctgaaga tgaagatggc tgggctgaat     2280

gctatccaga tgtacgtgcc ctggaacttc catgaacccc aaccaggaca atatgagttt     2340

tctggggacc gtgatgtgga gcatttcatc cagctggctc atgagctggg actcctggtg     2400

atcctgaggc ctgggcccta catctgtgca gagtgggaca tggggggctt acctgcttgg     2460

ctactagaga aacaatctat cgttctccgg tcttctgacc cagactacct tgtagctgtg     2520

gataaatggc tggcagtcct tctgcccaag atgaagcccc tgctctacca gaacggagga     2580

ccgatcataa ccgtgcaggt tgagaatgag tacgggtcct actttgcctg cgattacgac     2640

tacctacgct tcctggtgca ccgcttccgc taccatctgg gtaatgacgt cattctcttc     2700

accaccgacg gagcaagtga aaaaatgctg aagtgtggga ccctgcagga cctgtacgcc     2760

acagtggatt ttggaacagg caacaatatc acacaagctt tcctggtcca gaggaagttt     2820

gaacctaaag gacctttgat caattctgag ttctatactg gctggctaga ccactggggt     2880

aaaccccatt ccacggtgaa aactaaaaca ctggctacct ccctctataa cctgcttgcc     2940

cgtggggcca acgtgaactt gtacatgttt ataggtggga ccaattttgc ctattggaat     3000

ggtgccaaca cgccctatga gccacagccc accagctatg actacgacgc cccactgagc     3060

gaggctgggg acctcactaa gaagtatttt gctcttcgag aagtcattca gatgtttaaa     3120

gaagtcccag aaggccctat ccctccgtct acacccaaat ttgcatatgg aaaagttgct     3180

ctgagaaagt tcaagacagt ggctgaagct ctgggtatcc tgtgtcccaa tgggccagtg     3240

aaaagcctct atcccctgac attcactcag gtaaaacagt attttgggta tgtgctgtac     3300

cgaacaacgc ttcctcaaga ttgcagtaac ccgaaaccca ttttctcttc acccttcaat     3360

ggtgtccgtg atcgggctta cgtctctgtg gacggggtcc cccaaggaat ccttgatcga     3420

aacctcatga cagctctgaa catacggggg aaggctggag ccacgctgga catcctggtg     3480

gagaacatgg ggcgtgtgaa ctatggcaga ttcatcaatg acttcaaggg tttgatttcc     3540

aacatgacta tcaactccac tgtcctcacc aactggacgg tcttcccact gaacactgag     3600

gccatggtac gcaaccatct ctggggccgg gaggccagtg atgagggtca ccttgacgga     3660

cggtcgacct ccaattcttc ggacctcata ctccccacct tttacgtggg caacttctcc     3720

atcccctcgg gcatcccaga cctgccacag gacaccttca tccagtttcc tgggtggtcc     3780

aagggtcaag tatggatcaa tggctttaac ctcggccgat actggcccac aatgggccca     3840

caaaagacct tgttcgtgcc aaggaacatc ctgaccactt cagccccaaa caacatcaca     3900

gtgttggagc tagagtttgc accctgcagc gaggggaccc cagagctgtg tacagtagag     3960

tttgttgaca ctccggtcat ttcctgactc gagttttttt ttgcggccgc ttcgagcaga     4020

catgataaga tacattgatg agtttggaca aaccacaact agaatgcagt gaaaaaaatg     4080

ctttatttgt gaaatttgtg atgctattgc tttatttgta accattataa gctgcaataa     4140

acaagttaac aacaacaatt gcattcattt tatgtttcag gttcaggggg agatgtggga     4200

ggttttttaa agcaagtaaa acctctacaa atgtggtaaa atcgataggc cgcaggaacc     4260

cctagtgatg gagttggcca ctccctctct gcgcgctcgc tcgctcactg aggccgggcg     4320

accaaaggtc gcccgacgcc cgggcggcct cagtgagcga gcgagcgcgc agctgcctgc     4380

aggacatgtg agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg     4440

cgtttttcca taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga     4500

ggtggcgaaa cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg     4560

tgcgctctcc tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg     4620

gaagcgtggc gctttctcat agctcacgct gtaggtatct cagttcggtg taggtcgttc     4680

gctccaagct gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg     4740

gtaactatcg tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca     4800

ctggtaacag gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt     4860

ggcctaacta cggctacact agaagaacag tatttggtat ctgcgctctg ctgaagccag     4920

ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg     4980

gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc     5040

ctttgatctt ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt     5100

tggtcatgag attatcaaaa aggatcttca cctagatcct tttaaattaa aaatgaagtt     5160

ttaaatcaat ctaaagtata tatgagtaaa cttggtctga cagttaccaa tgcttaatca     5220

gtgaggcacc tatctcagcg atctgtctat ttcgttcatc catagttgcc tgactccccg     5280

tcgtgtagat aactacgata cgggagggct taccatctgg ccccagtgct gcaatgatac     5340

cgcgagaccc acgctcaccg gctccagatt tatcagcaat aaaccagcca gccggaaggg     5400

ccgagcgcag aagtggtcct gcaactttat ccgcctccat ccagtctatt aattgttgcc     5460

gggaagctag agtaagtagt tcgccagtta atagtttgcg caacgttgtt gccattgcta     5520

caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc ggttcccaac     5580

gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc     5640

ctccgatcgt tgtcagaagt aagttggccg cagtgttatc actcatggtt atggcagcac     5700

tgcataattc tcttactgtc atgccatccg taagatgctt ttctgtgact ggtgagtact     5760

caaccaagtc attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa     5820

tacgggataa taccgcgcca catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt     5880

cttcggggcg aaaactctca aggatcttac cgctgttgag atccagttcg atgtaaccca     5940

ctcgtgcacc caactgatct tcagcatctt ttactttcac cagcgtttct gggtgagcaa     6000

aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa tgttgaatac     6060

tcatactctt cctttttcaa tattattgaa gcatttatca gggttattgt ctcatgagcg     6120

gatacatatt tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc acatttcccc     6180

gaaaagtgcc acctgacgtc taagaaacca ttattatcat gacattaacc tataaaaata     6240

ggcgtatcac gaggcccttt cgtctcgcgc gtttcggtga tgacggtgaa aacctctgac     6300

acatgcagct cccggagacg gtcacagctt gtctgtaagc ggatgccggg agcagacaag     6360

cccgtcaggg cgcgtcagcg ggtgttggcg ggtgtcgggg ctggcttaac tatgcggcat     6420

cagagcagat tgtactgaga gtgcaccata aaattgtaaa cgttaatatt ttgttaaaat     6480

tcgcgttaaa tttttgttaa atcagctcat tttttaacca atagaccgaa atcggcaaaa     6540

tcccttataa atcaaaagaa tagcccgaga tagagttgag tgttgttcca gtttggaaca     6600

agagtccact attaaagaac gtggactcca acgtcaaagg gcgaaaaacc gtctatcagg     6660

gcgatggccc actacgtgaa ccatcaccca aatcaagttt tttggggtcg aggtgccgta     6720

aagcactaaa tcggaaccct aaagggagcc cccgatttag agcttgacgg ggaaagccgg     6780

cgaacgtggc gagaaaggaa gggaagaaag cgaaaggagc gggcgctaag gcgctggcaa     6840

gtgtagcggt cacgctgcgc gtaaccacca cacccgccgc gcttaatgcg ccgctacagg     6900

gcgcgtacta tggttgcttt gacgtatgcg gtgtgaaata ccgcacagat gcgtaaggag     6960

aaaataccgc atcaggcgcc                                                 6980


<210>  11
<211>  6813
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  11
ggttggccac tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg       60

cccgacgccc gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc agagagggag      120

tggccaactc catcactagg ggttcctaga tcttcaatat tggccattag ccatattatt      180

cattggttat atagcataaa tcaatattgg ctattggcca ttgcatacgt tgtatctata      240

tcataatatg tacatttata ttggctcatg tccaatatga ccgccatgtt ggcattgatt      300

attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga      360

gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg      420

cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg      480

acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca      540

tatgccaagt ccgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc      600

ccagtacatg accttacggg actttcctac ttggcagtac atctacgtat tagtcatcgc      660

tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct cccccccctc      720

cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga tgggggcggg      780

gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg gcggggcgag      840

gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc cttttatggc      900

gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg gagtcgctgc      960

gacgctgcct tcgccccgtg ccccgctccg ccgccgcctc gcgccgcccg ccccggctct     1020

gactgaccgc gttactccca caggtgagcg ggcgggacgg cccttctcct ccgggctgta     1080

attagcgctt ggtttaatga cggcttgttt cttttctgtg gctgcgtgaa agccttgagg     1140

ggctccggga gggccctttg tgcggggggg agcggctcgg ggggtgcgtg cgtgtgtgtg     1200

tgcgtgggga gcgccgcgtg cggcccgcgc tgcccggcgg ctgtgagcgc tgcgggcgcg     1260

gcgcggggct ttgtgcgctc cgcagtgtgc gcgaggggag cgcggccggg ggcggtgccc     1320

cgcggtgcgg ggggggctgc gaggggaaca aaggctgcgt gcggggtgtg tgcgtggggg     1380

ggtgagcagg gggtgtgggc gcggcggtcg ggctgtaacc cccccctgca cccccctccc     1440

cgagttgctg agcacggccc ggcttcgggt gcggggctcc gtacggggcg tggcgcgggg     1500

ctcgccgtgc cgggcggggg gtggcggcag gtgggggtgc cgggcggggc ggggccgcct     1560

cgggccgggg agggctcggg ggaggggcgc ggcggccccc ggagcgccgg cggctgtcga     1620

ggcgcggcga gccgcagcca ttgcctttta tggtaatcgt gcgagagggc gcagggactt     1680

cctttgtccc aaatctgtgc ggagccgaaa tctgggaggc gccgccgcac cccctctagc     1740

gggcgcgggg cgaagcggtg cggcgccggc aggaaggaaa tgggcgggga gggccttcgt     1800

gcgtcgccgc gccgccgtcc ccttctccct ctccagcctc ggggctgtcc gcggggggac     1860

ggctgccttc gggggggacg gggcagggcg gggttcggct tctggcgtgt gaccggcggc     1920

tctagagcct ctgctaacca tgttcatgcc ttcttctttt tcctacagct cctgggcaac     1980

gtgctggtta ttgtgctgtc tcatcatttt ggcaaagaat tcgatatcaa gcttgctagc     2040

gccaccatga cttccagtcc ccgggcgcct cctggagagc aaggacgcgg gggagcagag     2100

atgatccgag cagcgcctcc accactgttc ttgttgctgc tcctgttgct gttgctagtg     2160

tcctgggcgt cccgaggcga ggcagccccc gaccaggacg agatccagcg cctccccggg     2220

ctggccaagc agccgtcttt ccgccagtac tccggctacc tcaaaggctc cggctccaag     2280

cacctccact actggtttgt ggagtcccag aaggatcccg agaacagccc tgtggtgctt     2340

tggctcaatg ggggtcccgg ctgcagctca ctagatgggc tcctcacaga gcatggcccc     2400

ttcctggtcc agccagatgg tgtcaccctg gagtacaacc cctattcttg gaatctgatt     2460

gccaatgtgt tatacctgga gtccccagct ggggtgggct tctcctactc cgatgacaag     2520

ttttatgcaa ctaatgacac tgaggtcgcc cagagcaatt ttgaggccct tcaagatttc     2580

ttccgcctct ttccggagta caagaacaac aaacttttcc tgaccgggga gagctatgct     2640

ggcatctaca tccccaccct ggccgtgctg gtcatgcagg atcccagcat gaaccttcag     2700

gggctggctg tgggcaatgg actctcctcc tatgagcaga atgacaactc cctggtctac     2760

tttgcctact accatggcct tctggggaac aggctttggt cttctctcca gacccactgc     2820

tgctctcaaa acaagtgtaa cttctatgac aacaaagacc tggaatgcgt gaccaatctt     2880

caggaagtgg cccgcatcgt gggcaactct ggcctcaaca tctacaatct ctatgccccg     2940

tgtgctggag gggtgcccag ccattttagg tatgagaagg acactgttgt ggtccaggat     3000

ttgggcaaca tcttcactcg cctgccactc aagcggatgt ggcatcaggc actgctgcgc     3060

tcaggggata aagtgcgcat ggaccccccc tgcaccaaca caacagctgc ttccacctac     3120

ctcaacaacc cgtacgtgcg gaaggccctc aacatcccgg agcagctgcc acaatgggac     3180

atgtgcaact ttctggtaaa cttacagtac cgccgtctct accgaagcat gaactcccag     3240

tatctgaagc tgcttagctc acagaaatac cagatcctat tatataatgg agatgtagac     3300

atggcctgca atttcatggg ggatgagtgg tttgtggatt ccctcaacca gaagatggag     3360

gtgcagcgcc ggccctggtt agtgaagtac ggggacagcg gggagcagat tgccggcttc     3420

gtgaaggagt tctcccacat cgcctttctc acgatcaagg gcgccggcca catggttccc     3480

accgacaagc ccctcgctgc cttcaccatg ttctcccgct tcctgaacaa gcagccatac     3540

tgactcgagc ggccgcttcg agcagacatg ataagataca ttgatgagtt tggacaaacc     3600

acaactagaa tgcagtgaaa aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta     3660

tttgtaacca ttataagctg caataaacaa gttaacaaca acaattgcat tcattttatg     3720

tttcaggttc agggggagat gtgggaggtt ttttaaagca agtaaaacct ctacaaatgt     3780

ggtaaaatcg ataggccgca ggaaccccta gtgatggagt tggccactcc ctctctgcgc     3840

gctcgctcgc tcactgaggc cgcccgggca aagcccgggc gtcgggcgac ctttggtcgc     3900

ccggcctcag tgagcgagcg agcgcgcaga gagggagtgg ccaacccccc cccccccccc     3960

cctgcagcct ggcgtaatag cgaagaggcc cgcaccgatc gcccttccca acagttgcgt     4020

agcctgaatg gcgaatggcg cgacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg     4080

gtggttacgc gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct     4140

ttcttccctt cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg     4200

ctccctttag ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag     4260

ggtgatggtt cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg     4320

gagtccacgt tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc     4380

tcggtctatt cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat     4440

gagctgattt aacaaaaatt taacgcgaat tttaacaaaa tattaacgtt tacaatttcc     4500

tgatgcggta ttttctcctt acgcatctgt gcggtatttc acaccgcata tggtgcactc     4560

tcagtacaat ctgctctgat gccgcatagt taagccagcc ccgacacccg ccaacacccg     4620

ctgacgcgcc ctgacgggct tgtctgctcc cggcatccgc ttacagacaa gctgtgaccg     4680

tctccgggag ctgcatgtgt cagaggtttt caccgtcatc accgaaacgc gcgagacgaa     4740

agggcctcgt gatacgccta tttttatagg ttaatgtcat gataataatg gtttcttaga     4800

cgtcaggtgg cacttttcgg ggaaatgtgc gcggaacccc tatttgttta tttttctaaa     4860

tacattcaaa tatgtatccg ctcatgagac aataaccctg ataaatgctt caataatatt     4920

gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc ccttattccc ttttttgcgg     4980

cattttgcct tcctgttttt gctcacccag aaacgctggt gaaagtaaaa gatgctgaag     5040

atcagttggg tgcacgagtg ggttacatcg aactggatct caacagcggt aagatccttg     5100

agagttttcg ccccgaagaa cgttttccaa tgatgagcac ttttaaagtt ctgctatgtg     5160

gcgcggtatt atcccgtatt gacgccgggc aagagcaact cggtcgccgc atacactatt     5220

ctcagaatga cttggttgag tactcaccag tcacagaaaa gcatcttacg gatggcatga     5280

cagtaagaga attatgcagt gctgccataa ccatgagtga taacactgcg gccaacttac     5340

ttctgacaac gatcggagga ccgaaggagc taaccgcttt tttgcacaac atgggggatc     5400

atgtaactcg ccttgatcgt tgggaaccgg agctgaatga agccatacca aacgacgagc     5460

gtgacaccac gatgcctgta gcaatggcaa caacgttgcg caaactatta actggcgaac     5520

tacttactct agcttcccgg caacaattaa tagactggat ggaggcggat aaagttgcag     5580

gaccacttct gcgctcggcc cttccggctg gctggtttat tgctgataaa tctggagccg     5640

gtgagcgtgg gtctcgcggt atcattgcag cactggggcc agatggtaag ccctcccgta     5700

tcgtagttat ctacacgacg gggagtcagg caactatgga tgaacgaaat agacagatcg     5760

ctgagatagg tgcctcactg attaagcatt ggtaactgtc agaccaagtt tactcatata     5820

tactttagat tgatttaaaa cttcattttt aatttaaaag gatctaggtg aagatccttt     5880

ttgataatct catgaccaaa atcccttaac gtgagttttc gttccactga gcgtcagacc     5940

ccgtagaaaa gatcaaagga tcttcttgag atcctttttt tctgcgcgta atctgctgct     6000

tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa gagctaccaa     6060

ctctttttcc gaaggtaact ggcttcagca gagcgcagat accaaatact gtccttctag     6120

tgtagccgta gttaggccac cacttcaaga actctgtagc accgcctaca tacctcgctc     6180

tgctaatcct gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt accgggttgg     6240

actcaagacg atagttaccg gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca     6300

cacagcccag cttggagcga acgacctaca ccgaactgag atacctacag cgtgagcatt     6360

gagaaagcgc cacgcttccc gaagggagaa aggcggacag gtatccggta agcggcaggg     6420

tcggaacagg agagcgcacg agggagcttc cagggggaaa cgcctggtat ctttatagtc     6480

ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt gtgatgctcg tcaggggggc     6540

ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc ttttgctggc     6600

cttttgctca catgttcttt cctgcgttat cccctgattc tgtggataac cgtattaccg     6660

cctttgagtg agctgatacc gctcgccgca gccgaacgac cgagcgcagc gagtcagtga     6720

gcgaggaagc ggaagagcgc ccaatacgca aaccgcctct ccccgcgcgt tggccgattc     6780

attaatgcag ggctgcaggg gggggggggg ggg                                  6813


<210>  12
<211>  6797
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  12
ggttggccac tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg       60

cccgacgccc gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc agagagggag      120

tggccaactc catcactagg ggttcctaga tcttcaatat tggccattag ccatattatt      180

cattggttat atagcataaa tcaatattgg ctattggcca ttgcatacgt tgtatctata      240

tcataatatg tacatttata ttggctcatg tccaatatga ccgccatgtt ggcattgatt      300

attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga      360

gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg      420

cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg      480

acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca      540

tatgccaagt ccgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc      600

ccagtacatg accttacggg actttcctac ttggcagtac atctacgtat tagtcatcgc      660

tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct cccccccctc      720

cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga tgggggcggg      780

gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg gcggggcgag      840

gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc cttttatggc      900

gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg gagtcgctgc      960

gacgctgcct tcgccccgtg ccccgctccg ccgccgcctc gcgccgcccg ccccggctct     1020

gactgaccgc gttactccca caggtgagcg ggcgggacgg cccttctcct ccgggctgta     1080

attagcgctt ggtttaatga cggcttgttt cttttctgtg gctgcgtgaa agccttgagg     1140

ggctccggga gggccctttg tgcggggggg agcggctcgg ggggtgcgtg cgtgtgtgtg     1200

tgcgtgggga gcgccgcgtg cggcccgcgc tgcccggcgg ctgtgagcgc tgcgggcgcg     1260

gcgcggggct ttgtgcgctc cgcagtgtgc gcgaggggag cgcggccggg ggcggtgccc     1320

cgcggtgcgg ggggggctgc gaggggaaca aaggctgcgt gcggggtgtg tgcgtggggg     1380

ggtgagcagg gggtgtgggc gcggcggtcg ggctgtaacc cccccctgca cccccctccc     1440

cgagttgctg agcacggccc ggcttcgggt gcggggctcc gtacggggcg tggcgcgggg     1500

ctcgccgtgc cgggcggggg gtggcggcag gtgggggtgc cgggcggggc ggggccgcct     1560

cgggccgggg agggctcggg ggaggggcgc ggcggccccc ggagcgccgg cggctgtcga     1620

ggcgcggcga gccgcagcca ttgcctttta tggtaatcgt gcgagagggc gcagggactt     1680

cctttgtccc aaatctgtgc ggagccgaaa tctgggaggc gccgccgcac cccctctagc     1740

gggcgcgggg cgaagcggtg cggcgccggc aggaaggaaa tgggcgggga gggccttcgt     1800

gcgtcgccgc gccgccgtcc ccttctccct ctccagcctc ggggctgtcc gcggggggac     1860

ggctgccttc gggggggacg gggcagggcg gggttcggct tctggcgtgt gaccggcggc     1920

tctagagcct ctgctaacca tgttcatgcc ttcttctttt tcctacagct cctgggcaac     1980

gtgctggtta ttgtgctgtc tcatcatttt ggcaaagaat tcgatatcaa gcttgctagc     2040

gccaccatga cttccagtcc aaaggcgcct cctggagagc aaggacgcaa ggaagcagag     2100

atgcccggaa ccgcgctgtc tccactgctc ttgttgctgc tcctgtcctg ggcgtcccgg     2160

aacgaagcag ctccggacca ggatgaaatc gattgtctcc ccggcctggc caagcagccc     2220

tctttccggc aatactccgg ctacctcaga gcatcggact ccaagcactt ccactactgg     2280

tttgtggagt cgcagaacga cccaaagaac agccccgtgg tgctttggct taacgggggt     2340

cccggctgca gctcgctcga tgggctgctt acagagcacg gcccctttct gatccagcca     2400

gatggtgtca ccctggagta caacccctat gcttggaacc tgattgccaa cgtgctgtat     2460

atcgagtccc cagctggggt gggcttctcc tactcggatg acaagatgta cgtgaccaat     2520

gacacagagg tggcggagaa caattatgaa gcccttaaag acttcttccg cctctttccg     2580

gaatacaagg acaacaaact tttcctgaca ggagagagct atgctggcat ctacatcccc     2640

accttggctg tactggtcat gcaggatcct agcatgaatc ttcaggggct ggctgtgggc     2700

aatggacttg cctcctatga gcagaacgac aactccctgg tctactttgc ctactaccat     2760

ggccttctgg ggaacagact ttggacttca ctgcagaccc actgctgcgc tcagaacaag     2820

tgtaacttct atgacaacaa agacccagag tgtgtaaaca atctcctgga agtgtctcga     2880

attgtgggca aatctggcct caacatctac aatctctatg ctccgtgtgc tggtggggtg     2940

cccggcagac atagatatga ggacacactt gtagtccagg attttggcaa catcttcact     3000

cgcctgccac ttaagcggag atttcctgag gcactgatgc gttctgggga caaggtacgc     3060

ttggatcctc cctgcaccaa caccacagcc ccttccaact acctcaacaa cccctatgtt     3120

cggaaggctc tccacatccc cgagtcgctg ccccgctggg acatgtgcaa cttcttggtg     3180

aatttacagt accgccgcct ctaccaaagc atgaactccc agtacctgaa gctgctcagt     3240

tcacagaaat accagatcct gctctacaac ggagatgtgg acatggcctg caacttcatg     3300

ggcgatgagt ggtttgtgga ttcgctcaac cagaagatgg aggtgcagcg ccggccctgg     3360

ctagtggact acggggagag cggagaacag gtagctggtt tcgtgaagga gtgttcacac     3420

atcaccttcc tcaccatcaa gggtgccgga cacatggtcc ccacggacaa gcctcgagct     3480

gcttttacca tgttctcgag gttcctgaac aaagagcctt actgactcga gcggccgctt     3540

cgagcagaca tgataagata cattgatgag tttggacaaa ccacaactag aatgcagtga     3600

aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac cattataagc     3660

tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt tcagggggag     3720

atgtgggagg ttttttaaag caagtaaaac ctctacaaat gtggtaaaat cgataaggat     3780

ctgaggaacc cctagtgatg gagttggcca ctccctctct gcgcgctcgc tcgctcactg     3840

aggccgcccg ggcaaagccc gggcgtcggg cgacctttgg tcgcccggcc tcagtgagcg     3900

agcgagcgcg cagagaggga gtggccaacc cccccccccc cccccctgca gcctggcgta     3960

atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgtagcctg aatggcgaat     4020

ggcgcgacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg     4080

tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc ccttcctttc     4140

tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct ttagggttcc     4200

gatttagtgc tttacggcac ctcgacccca aaaaacttga ttagggtgat ggttcacgta     4260

gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc acgttcttta     4320

atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc tattcttttg     4380

atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg atttaacaaa     4440

aatttaacgc gaattttaac aaaatattaa cgtttacaat ttcctgatgc ggtattttct     4500

ccttacgcat ctgtgcggta tttcacaccg catatggtgc actctcagta caatctgctc     4560

tgatgccgca tagttaagcc agccccgaca cccgccaaca cccgctgacg cgccctgacg     4620

ggcttgtctg ctcccggcat ccgcttacag acaagctgtg accgtctccg ggagctgcat     4680

gtgtcagagg ttttcaccgt catcaccgaa acgcgcgaga cgaaagggcc tcgtgatacg     4740

cctattttta taggttaatg tcatgataat aatggtttct tagacgtcag gtggcacttt     4800

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta     4860

tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat     4920

gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt     4980

ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg     5040

agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga     5100

agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg     5160

tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt     5220

tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg     5280

cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg     5340

aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga     5400

tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc     5460

tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc     5520

ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc     5580

ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg     5640

cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac     5700

gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc     5760

actgattaag cattggtaac tgtcagacca agtttactca tatatacttt agattgattt     5820

aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac     5880

caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa     5940

aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc     6000

accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt     6060

aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg     6120

ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc     6180

agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt     6240

accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga     6300

gcgaacgacc tacaccgaac tgagatacct acagcgtgag cattgagaaa gcgccacgct     6360

tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg     6420

cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca     6480

cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa     6540

cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt     6600

ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga     6660

taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga     6720

gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat gcagggctgc     6780

aggggggggg ggggggg                                                    6797

