                         SEQUENCE LISTING

<110>  University of Massachusetts
 
<120>  MODIFIED AAV CONSTRUCTS AND USES THEREOF

<130>  U0120.70108WO00

<140>  PCT/US2019/032505
<141>  2019-05-15

<150>  US 62/671,908
<151>  2018-05-15

<160>  81    

<170>  PatentIn version 3.5

<210>  1
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  1
catcatcaat ttcgagcaga attcaagaga ttctgctcga aattgatgat gttttt           56


<210>  2
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  2
cgggattcta ccagatatct attcaagaga tagatatctg gtagaatccc gttttt           56


<210>  3
<211>  286
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  3
agatctaggg ctctgcgttt gctccaggta gtccgctgct cccttgggcc tgggcccact       60

gacagccctg gtgcctctgg ccggctgcac acctcctggc gggcagctgt gttctgctcg      120

aaattgatga tgtgttctgg caatacctgc atcatcatat ccgagcagaa cacggaggcc      180

tgccctgact gcccacggtg ccgtggccaa agaggatcta agggcaccgc tgagggccta      240

cctaaccatc gtggggaata aggacagtgt cacccttttt ctgcag                     286


<210>  4
<211>  286
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  4
agatctaggg ctctgcgttt gctccaggta gtccgctgct cccttgggcc tgggcccact       60

gacagccctg gtgcctctgg ccggctgcac acctcctggc gggcagctgt gtagatatct      120

ggtagaatcc cgtgttctgg caatacctgc gggattcgcc aagatatcta cacggaggcc      180

tgccctgact gcccacggtg ccgtggccaa agaggatcta agggcaccgc tgagggccta      240

cctaaccatc gtggggaata aggacagtgt cacccttttt ctgcag                     286


<210>  5
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  5
atcgggcccg actgcagttt cagcgtttg                                         29


<210>  6
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  6
cgcgggcccg actttacatt acacacaat                                         29


<210>  7
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  7
agggctctgc gtttgctcca gg                                                22


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  8
agggtgacac tgtccttatt                                                   20


<210>  9
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  9
gccccttctc tttggcag                                                     18


<210>  10
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  10
ttggccagca agcttgg                                                      17


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  11
ggaaggcatt gtggggcgta a                                                 21


<210>  12
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  12
tgcaaagtct ctggctgtc                                                    19


<210>  13
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  13
atttcaggtc gtcccatatg tc                                                22


<210>  14
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  14
gtccctcacc ttccggatga tag                                               23


<210>  15
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  15
ctcagtcctg ggcctacttt ttcca                                             25


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  16
tgccacgtca gaagagttca g                                                 21


<210>  17
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  17
ggattcccag cctttaaaat atttac                                            26


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  18
ggattaaaag atccatgaag                                                   20


<210>  19
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  19
gatatcgact gttggcatta agcccc                                            26


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  20
gactttccaa gtctcacaag                                                   20


<210>  21
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  21
accgcggtgc tcaggtgaga g                                                 21


<210>  22
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  22
cagagactga gcacggt                                                      17


<210>  23
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  23
ttttgcctcc atccagaagt gc                                                22


<210>  24
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  24
ggaagagtgg tgaacacagg a                                                 21


<210>  25
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  25
agtctgggta ccccacctcc agag                                              24


<210>  26
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  26
gcacagtgaa gaggaaaatg taccc                                             25


<210>  27
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  27
aggtacaggc taggtcttgt cc                                                22


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  28
agctccgtgc tccgtagtct                                                   20


<210>  29
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  29
gtgtttgaca cttagtagat ga                                                22


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  30
aatatatttc tttgcttagc                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  31
tttctctttg caggtgctgc                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  32
gtctgacatc tacgttcatc                                                   20


<210>  33
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  33
tgactttcat ctgtactaca ttcaagagat gtagtacaga tgaaagtcag cttttt           56


<210>  34
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  34
cgcctcgaga aattgaagaa gatctgttaa c                                      31


<210>  35
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  35
cgcgcggccg ctcttctctg gaggggactg t                                      31


<210>  36
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  36
cgcctcgagc ccaaaatgaa tgcttctttc tcg                                    33


<210>  37
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  37
cgcgcggccg ccctgaagaa tctggttctt c                                      31


<210>  38
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  38
ataactcgag cgaaggccgt gtgcgtgctg aagggc                                 36


<210>  39
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  39
gccagcggcc gcttgggcga tcccaattac accacaag                               38


<210>  40
<211>  286
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  40
agatctaggg ctctgcgttt gctccaggta gtccgctgct cccttgggcc tgggcccact       60

gacagccctg gtgcctctgg ccggctgcac acctcctggc gggcagctgt gtgtagtaca      120

gatgaaagtc agtgttctgg caatacctgc tgactttact atgtactaca cacggaggcc      180

tgccctgact gcccacggtg ccgtggccaa agaggatcta agggcaccgc tgagggccta      240

cctaaccatc gtggggaata aggacagtgt cacccttttt ctgcag                     286


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  41
gtccaggttg aatcacgggt                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  42
aggatcctgc aaggtcaagc                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  43
aaaggccgct gctttgaaag                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  44
ccgcacctga atttgttgca                                                   20


<210>  45
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  45
atgccaacac agtgctgtct gg                                                22


<210>  46
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  46
tgcttgctga tccacatctg ct                                                22


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  47
agcaaagacc ccaacgagaa                                                   20


<210>  48
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  48
ggcggcggtc acgaa                                                        15


<210>  49
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  49
cgcgatcaca tggtcctgct gg                                                22


<210>  50
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  50
gactttcatc tgtactaca                                                    19


<210>  51
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  51
ctctgtatcg ttccaatttt agtata                                            26


<210>  52
<211>  111
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  52
ugcacaccuc cuggcgggca gcuguggugc auuguaguug cauugcaugu ucuggcaaua       60

ggcgugcaau guuuccacag ugcaucacgg aggcctgccc ugacugccca c               111


<210>  53
<211>  53
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  53
cugacuuuca ucuguacuac auucaagaga uguaguacag augaaaguca guu              53


<210>  54
<211>  111
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  54
ugcacaccuc cuggcgggca gcugugugua guacagauga aagucagugu ucuggcaaua       60

ccuguggacu uuacuuugua cuacacacgg aggccugccc ugacugccca c               111


<210>  55
<211>  59
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  55
ucucgggauu cuaccagaua ucuauucaag agauagauau cugguagaau cccguuuuu        59


<210>  56
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  56
ccuggcgggc agcuguguag auaucuggua gaaucccgug uucuggcaau ccgugggauu       60

cgccuagauc uauacacgga ggccugcccu gacugccca                              99


<210>  57
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  57
tcctttcaga tgtcataact tcaagagatg tagtacagat gaaagtc                     47


<210>  58
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  58
tcctttcaga tgtcatacat tcaagagatg tagtacagat gaaagtc                     47


<210>  59
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  59
tcctttcatc tgtcataact tcaagagatg tagtacagat gaaagtc                     47


<210>  60
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  60
gactttcaga tgtcataact tcaagagatg tagtacagat gaaagtc                     47


<210>  61
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  61
tcctttcaga tgtactacat tcaagagatg tagtacagat gaaagtc                     47


<210>  62
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  62
gactggcaga tgtactacat tcaagagatg tagtacagat gaaagtc                     47


<210>  63
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  63
tcctttcatc tgtcatacat tcaagagatg tagtacagat gaaagtc                     47


<210>  64
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  64
gactttcaga tgtcatacat tcaagagatg tagtacagat gaaagtc                     47


<210>  65
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  65
tcctttcatc tgtactaact tcaagagatg tagtacagat gaaagtc                     47


<210>  66
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  66
gactggcatc tgtactaact tcaagagatg tagtacagat gaaagtc                     47


<210>  67
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  67
gactttcaga tgtactaact tcaagagatg tagtacagat gaaagtc                     47


<210>  68
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  68
gactttcatc tgtcataact tcaagagatg tagtacagat gaaagtc                     47


<210>  69
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  69
gactttcatc tgtactacat tcaagagatg tagtacagat gaaagag                     47


<210>  70
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  70
ctctttcatc tgtactacat tcaagagatg tagtacagat gaaagtc                     47


<210>  71
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  71
tcctttcatc tgtactacat tcaagagatg tagtacagat gaaagtc                     47


<210>  72
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  72
gactggcatc tgtactacat tcaagagatg tagtacagat gaaagtc                     47


<210>  73
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  73
gactttcaga tgtactacat tcaagagatg tagtacagat gaaagtc                     47


<210>  74
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  74
gactttcatc tgtcatacat tcaagagatg tagtacagat gaaagtc                     47


<210>  75
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  75
gactttcatc tgtactaact tcaagagatg tagtacagat gaaagtc                     47


<210>  76
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  76
gactttcatc tgtactacat tcaagagatg tagtacagat gaaagtc                     47


<210>  77
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  77
gactttcatc tgtactacat tcaagagatg tagtacagat gaaagtc                     47


<210>  78
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(11)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (14)..(18)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (22)..(46)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (51)..(59)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (61)..(85)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (89)..(93)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (95)..(99)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (104)..(106)
<223>  n is a, c, g, or u

<400>  78
nnnnnnnnnn nugnnnnncu cnnnnnnnnn nnnnnnnnnn nnnnnnugug nnnnnnnnna       60

nnnnnnnnnn nnnnnnnnnn nnnnngcgnn nnncnnnnnc gucnnn                     106


<210>  79
<211>  111
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  79
ugcacaccuc cuggcgggca gcuguggugc auuguaguug cauugcaugu ucuggcaaua       60

ccugugcaau guuuccacag ugcaucacgg aggcctgccc ugacugccca c               111


<210>  80
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  80
ugcacaccuc cuggcgggcu cuguggugca uuguaguugc auugcaugug cuggcaauac       60

cugugcaaug uuuccacagu gcaucacggc gcctgcccug accguccac                  109


<210>  81
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  81
ugcacaccuc cuggcgggcu cuguggugca uuguaguugc auugcaugug cuggcaauac       60

cugugcaaug uaacuacagu gcaucacggc gcctgcccug accguccac                  109


