                         SEQUENCE LISTING

<110>  Regents of the University of Minnesota
       Osborn, Mark J
       Hippen, Keli L
       Blazer, Bruce R
 
<120>  TREG GENOME ENGINEERING FOR STEROID AND CALCINEURIN INHIBITOR 
       RESISTANCE

<130>  920171.00229

<150>  US 62/672,868
<151>  2018-05-17

<160>  67    

<170>  PatentIn version 3.5

<210>  1
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  1

Met Ser Glu Pro Lys Ala Ile Asp Pro Lys Leu Ser Thr Thr Asp Arg 
1               5                   10                  15      


Val Val Lys Ala Val Pro Phe Pro Pro Ser His Arg Leu Thr Ala Lys 
            20                  25                  30          


Glu Val Phe Asp Asn Asp Gly Lys Pro Arg Val Asp Ile Leu Lys Ala 
        35                  40                  45              


His Leu Met Lys Glu Gly Arg Leu Glu Glu Ser Val Ala Leu Arg Ile 
    50                  55                  60                  


Ile Thr Glu Gly Ala Ser Ile Leu Arg Gln Glu Lys Asn Leu Leu Asp 
65                  70                  75                  80  


Ile Asp Ala Pro Val Thr Val Cys Gly Asp Ile His Gly Gln Phe Phe 
                85                  90                  95      


Asp Leu Met Lys Leu Phe Glu Val Gly Gly Ser Pro Ala Asn Thr Arg 
            100                 105                 110         


Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg Gly Tyr Phe Ser Ile Glu 
        115                 120                 125             


Cys Val Leu Tyr Leu Trp Ala Leu Lys Ile Leu Tyr Pro Lys Thr Leu 
    130                 135                 140                 


Phe Leu Leu Arg Gly Asn His Glu Cys Arg His Leu Thr Glu Tyr Phe 
145                 150                 155                 160 


Thr Phe Lys Gln Glu Cys Lys Ile Lys Tyr Ser Glu Arg Val Tyr Asp 
                165                 170                 175     


Ala Cys Met Asp Ala Phe Asp Cys Leu Pro Leu Ala Ala Leu Met Asn 
            180                 185                 190         


Gln Gln Phe Leu Cys Val His Gly Gly Leu Ser Pro Glu Ile Asn Thr 
        195                 200                 205             


Leu Asp Asp Ile Arg Lys Leu Asp Arg Phe Lys Glu Pro Pro Ala Tyr 
    210                 215                 220                 


Gly Pro Met Cys Asp Ile Leu Trp Ser Asp Pro Leu Glu Asp Phe Gly 
225                 230                 235                 240 


Asn Glu Lys Thr Gln Glu His Phe Thr His Asn Thr Val Arg Gly Cys 
                245                 250                 255     


Ser Tyr Phe Tyr Ser Tyr Pro Ala Val Cys Glu Phe Leu Gln His Asn 
            260                 265                 270         


Asn Leu Leu Ser Ile Leu Arg Ala His Glu Ala Gln Asp Ala Gly Tyr 
        275                 280                 285             


Arg Met Tyr Arg Lys Ser Gln Thr Thr Gly Phe Pro Ser Leu Ile Thr 
    290                 295                 300                 


Ile Phe Ser Ala Pro Asn Tyr Leu Asp Val Tyr Asn Asn Lys Ala Ala 
305                 310                 315                 320 


Val Leu Lys Tyr Glu Asn Asn Val Met Asn Ile Arg Gln Phe Asn Cys 
                325                 330                 335     


Ser Pro His Pro Tyr Trp Leu Pro Asn Phe Met Asp Val Phe Thr Trp 
            340                 345                 350         


Ser Leu Pro Phe Val Gly Glu Lys Val Thr Glu Met Leu Val Asn Val 
        355                 360                 365             


Leu Asn Ile Cys Ser Asp Asp Glu Leu Gly Ser Glu Glu Asp Gly Phe 
    370                 375                 380                 


Asp Gly Ala Thr Ala Ala Ala Arg Lys Glu Val Ile Arg Asn Lys Ile 
385                 390                 395                 400 


Arg Ala Ile Gly Lys Met Ala Arg Val Phe Ser Val Leu Arg Glu Glu 
                405                 410                 415     


Ser Glu Ser Val Leu Thr Leu Lys Gly Leu Thr Pro Thr Gly Met Leu 
            420                 425                 430         


Pro Ser Gly Val Leu Ser Gly Gly Lys Gln Thr Leu Gln Ser Ala Thr 
        435                 440                 445             


Val Glu Ala Ile Glu Ala Asp Glu Ala Ile Lys Gly Phe Ser Pro Gln 
    450                 455                 460                 


His Lys Ile Thr Ser Phe Glu Glu Ala Lys Gly Leu Asp Arg Ile Asn 
465                 470                 475                 480 


Glu Arg Met Pro Pro Arg Arg Asp Ala Met Pro Ser Asp Ala Asn Leu 
                485                 490                 495     


Asn Ser Ile Asn Lys Ala Leu Thr Ser Glu Thr Asn Gly Thr Asp Ser 
            500                 505                 510         


Asn Gly Ser Asn Ser Ser Asn Ile Gln 
        515                 520     


<210>  2
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  2

Met Gly Asn Glu Ala Ser Tyr Pro Leu Glu Met Cys Ser His Phe Asp 
1               5                   10                  15      


Ala Asp Glu Ile Lys Arg Leu Gly Lys Arg Phe Lys Lys Leu Asp Leu 
            20                  25                  30          


Asp Asn Ser Gly Ser Leu Ser Val Glu Glu Phe Met Ser Leu Pro Glu 
        35                  40                  45              


Leu Gln Gln Asn Pro Leu Val Gln Arg Val Ile Asp Ile Phe Asp Thr 
    50                  55                  60                  


Asp Gly Asn Gly Glu Val Asp Phe Lys Glu Phe Ile Glu Gly Val Ser 
65                  70                  75                  80  


Gln Phe Ser Val Lys Gly Asp Lys Glu Gln Lys Leu Arg Phe Ala Phe 
                85                  90                  95      


Arg Ile Tyr Asp Met Asp Lys Asp Gly Tyr Ile Ser Asn Gly Glu Leu 
            100                 105                 110         


Phe Gln Val Leu Lys Met Met Val Gly Asn Asn Leu Lys Asp Thr Gln 
        115                 120                 125             


Leu Gln Gln Ile Val Asp Lys Thr Ile Ile Asn Ala Asp Lys Asp Gly 
    130                 135                 140                 


Asp Gly Arg Ile Ser Phe Glu Glu Phe Cys Ala Val Val Gly Gly Leu 
145                 150                 155                 160 


Asp Ile His Lys Lys Met Val Val Asp Val 
                165                 170 


<210>  3
<211>  1566
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  3
atgagcgagc ccaaggccat cgaccccaag ctgtccacca ccgacagagt ggtgaaggcc       60

gtgccctttc ccccctccca ccgcctgacc gccaaggagg tgttcgacaa cgatggcaag      120

cccagagtgg acatcctgaa agcccacctg atgaaggagg gcagactgga ggagagcgtg      180

gccctgcgca tcatcaccga gggcgccagc atcctgcgcc aggagaagaa cctgctggat      240

atcgacgccc ctgtgaccgt gtgcggcgac atccacggac agtttttcga cctgatgaag      300

ctgttcgagg tgggcggctc tcccgccaac accagatacc tgttcctggg cgactacgtg      360

gacagaggct acttctctat cgagtgcgtg ctgtacctgt gggccctgaa gatcctgtac      420

cccaagaccc tgttcctgct gagaggcaac cacgagtgcc gccacctgac cgagtacttt      480

accttcaagc aggagtgcaa gatcaagtac agcgagcgcg tgtacgatgc ctgcatggac      540

gccttcgact gtctgcccct ggccgctctg atgaaccagc agttcctgtg tgtgcacgga      600

ggcctgagcc ccgagatcaa caccctggac gacatccgga agctggaccg cttcaaggag      660

ccccctgcct atggccccat gtgcgacatc ctgtggagcg accccctgga ggactttggc      720

aacgagaaga cccaggagca ctttacccac aacaccgtga gaggctgcag ctacttctac      780

tcctaccctg ctgtgtgcga gttcctgcag cacaacaacc tgctgagcat cctgagggcc      840

cacgaggccc aggatgccgg ctaccgcatg taccgcaagt cccagaccac cggcttcccc      900

tccctgatca ccatcttctc tgcccccaac tacctggacg tgtacaacaa caaagccgct      960

gtgctgaagt acgagaacaa cgtgatgaac atccggcagt tcaactgctc cccccacccc     1020

tactggctgc ccaacttcat ggacgtgttc gagtggagcg ccccctttgt gggcgagaag     1080

gtgaccgaga tgctggtgaa cgtgctgaac atctgctccg acgatgagct gggcagcgag     1140

gaggacggct tcgatggcgc caccgctgcc gccagaaagg aggtgatccg caataagatc     1200

agagccatcg gcaagatggc cagagtgttc tccgtgctgc gcgaggagag cgagtccgtg     1260

ctgaccctga agggcctgac ccccaccggc atgctgccct ccggcgtgct gagcggaggc     1320

aagcagaccc tgcagagcgc cacagtggag gccatcgagg ccgatgaggc catcaagggc     1380

ttctcccccc agcacaagat caccagcttc gaggaggcca agggcctgga ccggatcaac     1440

gagcggatgc cacccagacg ggatgccatg cccagcgatg ccaacctgaa ctccatcaac     1500

aaggccctga ccagcgagac caacggcacc gacagcaacg gcagcaactc ctccaacatc     1560

cagtga                                                                1566


<210>  4
<211>  1566
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  4
atgagcgagc ccaaggccat cgaccccaag ctgtccacca ccgacagagt ggtgaaggcc       60

gtgccctttc ccccctccca ccgcctgacc gccaaggagg tgttcgacaa cgatggcaag      120

cccagagtgg acatcctgaa agcccacctg atgaaggagg gcagactgga ggagagcgtg      180

gccctgcgca tcatcaccga gggcgccagc atcctgcgcc aggagaagaa cctgctggat      240

atcgacgccc ctgtgaccgt gtgcggcgac atccacggac agtttttcga cctgatgaag      300

ctgttcgagg tgggcggctc tcccgccaac accagatacc tgttcctggg cgactacgtg      360

gacagaggct acttctctat cgagtgcgtg ctgtacctgt gggccctgaa gatcctgtac      420

cccaagaccc tgttcctgct gagaggcaac cacgagtgcc gccacctgac cgagtacttt      480

accttcaagc aggagtgcaa gatcaagtac agcgagcgcg tgtacgatgc ctgcatggac      540

gccttcgact gtctgcccct ggccgctctg atgaaccagc agttcctgtg tgtgcacgga      600

ggcctgagcc ccgagatcaa caccctggac gacatccgga agctggaccg cttcaaggag      660

ccccctgcct atggccccat gtgcgacatc ctgtggagcg accccctgga ggactttggc      720

aacgagaaga cccaggagca ctttacccac aacaccgtga gaggctgcag ctacttctac      780

tcctaccctg ctgtgtgcga gttcctgcag cacaacaacc tgctgagcat cctgagggcc      840

cacgaggccc aggatgccgg ctaccgcatg taccgcaagt cccagaccac cggcttcccc      900

tccctgatca ccatcttctc tgcccccaac tacctggacc ggtacaacaa caaagccgct      960

gtgctgaagt acgagaacaa cgtgatgaac atccggcagt tcaactgctc cccccacccc     1020

ttctggctgc ccaacttcat ggacgtgttc acctggtccc tgccctttgt gggcgagaag     1080

gtgaccgaga tgctggtgaa cgtgctgaac atctgctccg acgatgagct gggcagcgag     1140

gaggacggct tcgatggcgc caccgctgcc gccagaaagg aggtgatccg caataagatc     1200

agagccatcg gcaagatggc cagagtgttc tccgtgctgc gcgaggagag cgagtccgtg     1260

ctgaccctga agggcctgac ccccaccggc atgctgccct ccggcgtgct gagcggaggc     1320

aagcagaccc tgcagagcgc cacagtggag gccatcgagg ccgatgaggc catcaagggc     1380

ttctcccccc agcacaagat caccagcttc gaggaggcca agggcctgga ccggatcaac     1440

gagcggatgc cacccagacg ggatgccatg cccagcgatg ccaacctgaa ctccatcaac     1500

aaggccctga ccagcgagac caacggcacc gacagcaacg gcagcaactc ctccaacatc     1560

cagtga                                                                1566


<210>  5
<211>  519
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  5
atgggcaacg aggccagcta ccctctggag atgtgctccc acttcgacgc cgacgagatc       60

aagcggctgg gcaagcgctt caagaagctg gacctggaca acagcggcag cctgagcgtg      120

gaggagttta tgtctctgcc cgagctgcag cagaaccccc tggtgcagcg cgtgatcgac      180

atcttcgaca ccgacggcaa cggcgaggtg gacttcaagg agttcatcga gggcgtgagc      240

cagttcagcg tgaagggcga caaggagcag aagctgcggt tcgccttccg gatctacgat      300

atggataaag atggctatat ttctaatggc gagctgttcc aggtgctgaa gatgatggtg      360

ggcaacaata ccaagctggc cgatacccag ctgcagcaga tcgtggacaa gaccatcatc      420

aacgccgaca aggacggcga cggcagaatc agcttcgagg agttctgtgc cgtggtggga      480

ggcctggata ttcacaaaaa aatggtggtg gacgtgtga                             519


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  6

Val Ile Val Ile Thr 
1               5   


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  7
aaccaaaagt cttcgctgct                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  8
ttgagaagcg acagccagtg                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  9
accaggagtt aatgattctt                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  10
tcctgagcaa gcacactgct                                                   20


<210>  11
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X = any naturally occuriring amino acid

<400>  11

Arg Xaa Lys Arg 
1               


<210>  12
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X = any naturally occurring amino acid

<400>  12

Arg Xaa Arg Arg 
1               


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = R or K

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X = any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X = R or K

<400>  13

Xaa Arg Xaa Xaa Arg 
1               5   


<210>  14
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  X = any naturally occurring amino acid

<400>  14

Arg Xaa Xaa Arg 
1               


<210>  15
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  15

Arg Gln Lys Arg 
1               


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  16
ugcucaggag aggggagaug                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  17
cuugcucagg agaggggaga                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  18
uucucaauca gacuccaagc                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  19
gggccaaauc agccuuuccu                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  20
ucagaacagc aacauuugaa                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  21
aagggccaga cuggcaccaa                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  22
ccccaaguga aaacagaaaa                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  23
uacugucagg caagcuuucc                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  24
acugucaggc aagcuuuccu                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  25
ggaggacaga uguaccacua                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  26
ccuuucucaa cagcaggauc                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  27
auuccaauuu ucggaaccaa                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  28
uuccaauuuu cggaaccaac                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  29
aggugccaag gaucuggaga                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  30
ggucgaacag uuuuuucuaa                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  31
uaucgaaaau gucuucaggc                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  32
ucuucaggcu ggaaugaacc                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  33
cuucaggcug gaaugaaccu                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  34
acagcucgaa aaacaaagaa                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  35
ggaauucagc aggccacuac                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  36
gaauucagca ggccacuaca                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  37
accacaacuc accccuaccc                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  38
uuaccacaac ucaccccuac                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  39
ugauccucca aguugagucu                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  40
cuccaaguug agucuggaac                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  41
ggaugaccaa augacccuac                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  42
acauccagga guacugcagu                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  43
aacauccagg aguacugcag                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  44
aggcuucagg uaucuuauga                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  45
caggcuucag guaucuuaug                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  46
aagagccaag agcuauuuga                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  47
uuaucaacug acaaaacucu                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  48
uaucaacuga caaaacucuu                                                   20


<210>  49
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  49
uuuaucaacu gacaaaacuc                                                   20


<210>  50
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  50
cuuccaaaca uuuuuggaua                                                   20


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  51
ccaaucagau accaaaauau                                                   20


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  52
aaccacauaa cauucuauaa                                                   20


<210>  53
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  53
guuucaucaa aagugacugc                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  54
gcuguccuau auggaauaaa                                                   20


<210>  55
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  55
uacucauuaa uaaucagauc                                                   20


<210>  56
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  56
aaccgtaaaa t                                                            11


<210>  57
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  57
gggccaaatc agcctttcct                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  58
tcagaacagc aacatttgaa                                                   20


<210>  59
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  59
ttttattcca tataggacag cacaattacc t                                      31


<210>  60
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  60
tttattccat ataggacag                                                    19


<210>  61
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  61
ttttattcca tataggacag c                                                 21


<210>  62
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  62
gattattaat gagta                                                        15


<210>  63
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  63
gatctgatta ttaatgagta                                                   20


<210>  64
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  64
tactcattaa taatcagatc                                                   20


<210>  65
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  65
tcagaacagc aacatttgaa ggg                                               23


<210>  66
<211>  5077
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  66
ctttaacaga agattcagtt tgaagaatag ggctctttgt tagtacttct gcttttaact       60

ctttaatctc aagctaacac ttaacgaatt tacaaataag gcagcacaac ttttgactat      120

gtaagtaagg gtatcattta ttgtaatata agaacatatt ctaaaacagc tgaatgacca      180

tgcacaacac aatatgatat tatgagacat tatactctcc tgaatttata taatttttcg      240

ttaagatatc tgttaatgag caacattatt ttaaaaatgt taaataaaat cctcaccgtt      300

ggccaatggg atactgaaaa ccactattta aggaaaaaac ctgaaatggt tacgtacaga      360

tgtcacttag gttgtctacc tttcctactt tcaaaaggcc acttaaactt attcatataa      420

aaaagcacat gaatctttag agaacacata taaatcaatg aagatttaca tctattaatc      480

taccttaaat gtaccattct taagaaacag aaaaacactg atcttacctt gaatagccat      540

tagaaaaaac tgttcgacca gggaagttca gagtccccag agaagtcaag ttgtcatctc      600

cagatccttg gcacctattc caattttcgg aaccaacggg aattggtgga atgacattaa      660

aaataggctt ctgatcctgc tgttgagaaa gggatgctgt attcatgtca tagtggtaca      720

tctgtcctcc agaggtactc acaccatgaa cagaaatggc agacatttta ttaccaatta      780

tatttgctcc aggaaagctt gcctgacagt aaactgtgcc cagtttctct tgcttaatta      840

ccccaggggt gcagagttcg atgaaatctt ctttttctgt tttcacttgg ggcagtgtta      900

cattactggg gcttgacaaa accagatctc cattatcctt aattttgggt ttagtgtccg      960

gtaaaatgag aggcttgcag tcctcattcg agtttccttc caaaaggaat gaatcgtctt     1020

ctcccgccag aggagaaagc aaacagtttt catctatcaa caggtctgat ctccaaggac     1080

tctcattcgt ctctttacct ggggacccag aagaaaactc caaatcctgc aaaatgtcaa     1140

aggtgctttg gtctgtggta tacaatttca cattgccacc gttggtgcca gtctggccct     1200

tcaaatgttg ctgttctgaa gatacatcag agtgagtttt tggaaactcc ttctctgtgg     1260

gggcagcaga cacagcagtg gatgctgaac tcttggggtt ctctggaaca ctggtcgacc     1320

tattgaggtt tgcaatgctt tcttccaaaa gctttaagtc tgtttccccc gaggaaaggc     1380

tgatttggcc ctgctgtggg aatcccaggt catttcccat cacttttgtt tctgtctctc     1440

ccatatacag tcccattgag agtgaaactg ctttggacag atctggctat cgatcacgag     1500

actagcctcg agaagcttga tatcgaattc cacggggttg gacgcgtctt aattaaggat     1560

ccaaggtcag gaacagagaa acaggagaat atgggccaaa caggatatct gtggtaagca     1620

gttcctgccc cggctcaggg ccaagaacag ttggaacagc agaatatggg ccaaacagga     1680

tatctgtggt aagcagttcc tgccccggct cagggccaag aacagatggt ccccagatgc     1740

ggtcccgccc tcagcagttt ctagagaacc atcagatgtt tccagggtgc cccaaggacc     1800

tgaaatgacc ctgtgcctta tttgaactaa ccaatcagtt cgcttctcgc ttctgttcgc     1860

gcgcttctgc tccccgagct ctatataagc agagctcgtt tagtgaaccg tcagatcgcc     1920

tggagacgcc atccacgctg ttttgacctc catagaagac accgactcta gaggatcgat     1980

cccccgggct gcaggaattc aagcgagaag acaagggcag aaagcaccat gggcaacgag     2040

gccagctacc ctctggagat gtgctcccac ttcgacgccg acgagatcaa gcggctgggc     2100

aagcgcttca agaagctgga cctggacaac agcggcagcc tgagcgtgga ggagtttatg     2160

tctctgcccg agctgcagca gaaccccctg gtgcagcgcg tgatcgacat cttcgacacc     2220

gacggcaacg gcgaggtgga cttcaaggag ttcatcgagg gcgtgagcca gttcagcgtg     2280

aagggcgaca aggagcagaa gctgcggttc gccttccgga tctacgatat ggataaagat     2340

ggctatattt ctaatggcga gctgttccag gtgctgaaga tgatggtggg caacaatacc     2400

aagctggccg atacccagct gcagcagatc gtggacaaga ccatcatcaa cgccgacaag     2460

gacggcgacg gcagaatcag cttcgaggag ttctgtgccg tggtgggagg cctggatatt     2520

cacaaaaaaa tggtggtgga cgtgctcgag ggcggcggag agggcagagg aagtcttcta     2580

acatgcggtg acgtggagga gaatcccggc cctagggtaa gcaaggggga ggagctgttc     2640

accggcgtag tacctatact ggtcgagttg gatggggacg tgaacggcca taaattctct     2700

gtgtctgggg agggcgaagg tgatgcgacc tacggaaagc tcaccctcaa attcatttgt     2760

acaacgggta agctgcctgt tccgtggccc accttggtaa ctaccttgac ttatggtgtc     2820

cagtgcttct ccaggtaccc agatcacatg aagcagcacg acttcttcaa atccgccatg     2880

cctgaaggct atgtgcaaga gcggacaatt ttttttaagg acgatggcaa ctataagact     2940

cgagccgaag ttaaatttga gggagacacc cttgtcaata ggatcgagct taaaggcatt     3000

gattttaagg aagacggaaa tatattgggc cataagctgg agtataacta caatagtcat     3060

aacgtgtaca tcatggctga caagcagaag aacgggatta aggtaaattt taagatcagg     3120

cataacatag aggacgggag cgtccaactt gccgaccact accagcaaaa taccccgata     3180

ggcgatggtc ctgtactgtt gccggataat cactacctct ctacgcaatc cgcgcttagt     3240

aaggatccta acgagaaacg cgaccacatg gtgcttctgg agttcgtaac tgctgctggc     3300

atcacacttg gcatggacga attgtacaaa tagcgctgat cagcctcgac tgtgccttct     3360

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     3420

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     3480

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     3540

agcaggcatg ctggggaagc tcgattgaga agcgacagcc agtgagggtg aagacgcaga     3600

aaccttcaca gtagctcctc ctcttagggt tttatagaag tccatcacat ctcccctctc     3660

ctgagcaagc acactgctgg ggttttcttc tctaccagga gttaatgatt ctttggagtc     3720

catcagtgaa tatcaactac aaaacaaaaa acaaaaacgg ggggaaaaca tcataagctc     3780

taaagtcaca ttatcttcct gatccgatta gtaagaggca gcttgttaaa tgaacctttt     3840

agttaactcc gaatcaaatt ctttgttacc agaagagtag tttctatctt ccagaataaa     3900

aagccatgtc ccctgctccc attcagcatg ccacatttaa aagtacaatg caatccattt     3960

gcacagctga gggcaaaagt gtatcgaact aagcttggct attcatcctg ccgctcactg     4020

aacgtgtagc tttgttaatc acagacatta taattcatta catctgatta ttctgaaggt     4080

tcaagttgat gtcaaagtat ttaatttcaa aaaaaggaag tgtgatcatt aaaattccta     4140

cctcttttca atcacggctg tttgcttttc tgagaaccaa tacatataac atttgataaa     4200

tactatgcta gaattctcaa tccctaatta cttccaaatt tccctcctac cagctagtca     4260

cacatccaaa cctttgagta caaccaactg gtgaaccatg cacgttttct ttgaaaaata     4320

aacaatgctg atctgcttat cttccgacag gctgggaaaa ggctttttaa cccatacttc     4380

tgactggatg tgcctacctc caaattttgg atatatgaaa tgagatacac tttatatagg     4440

ccaactaaaa tttagatttt aaagagcaga agagaaggtg tagtagtttc tcactacgtt     4500

gttagcttac ataacttaaa tatagctgac ccttatcata actcacaaaa acatctagat     4560

taagctacat ttgtttacat tgcttgagat cctcaatatg aaatgctatt acatctctaa     4620

gttctttcct ttccaaacaa atatcgaagt actgaaaaat ggaaaaacac agaaccgtaa     4680

aatcacattc atataaattc aggtacaact gtatccagta aaatgttcaa aataattttc     4740

tctgccttca cctatccaaa ccttcaccta tcccaattct cagcctattc tcaagagagt     4800

aagactgtta gtatatcgtt aatcagggtg ttttaagaga tgggctaaga cggagaagcg     4860

catttgggac actatagtca aatcccgtcc aataaaaggt aacttttcct atgcgatgac     4920

gttaggcagc ataaatgtca ctggccctca ctgaaaagtg aatatgaagg tagagagagg     4980

ggtgtggact tgccactaca aatcttgagg gtaaactgct tatctcccca cctctctgcc     5040

ccgtttatct gaggcgataa cgatctctaa acacgag                              5077


<210>  67
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  67

Met Ala Gly Pro His Pro Val Ile Val Ile Thr Gly Pro His Glu Glu 
1               5                   10                  15      


