                         SEQUENCE LISTING

<110>  Carina Biotech Pty Ltd.
 
<120>  CHIMERIC ANTIGEN RECEPTORS WITH MODIFIED LINKER DOMAIN AND USES 
       THEREOF

<130>  1105707

<160>  69    

<170>  PatentIn version 3.5

<210>  1
<211>  3680
<212>  DNA
<213>  Homo sapiens

<400>  1
gtcattggag gagcttgaag ttaaagactc ctgctaaaaa ccagtacgtt tcattttgca       60

gttactggga gggggcttgc tgtggccctg tcaggaagag tagagctctg gtccagctcc      120

gcgcagggag ggaggctgtc accatgccgg cctgctgcag ctgcagtgat gttttccagt      180

atgagacgaa caaagtcact cggatccaga gcatgaatta tggcaccatt aagtggttct      240

tccacgtgat catcttttcc tacgtttgct ttgctctggt gagtgacaag ctgtaccagc      300

ggaaagagcc tgtcatcagt tctgtgcaca ccaaggtgaa ggggatagca gaggtgaaag      360

aggagatcgt ggagaatgga gtgaagaagt tggtgcacag tgtctttgac accgcagact      420

acaccttccc tttgcagggg aactctttct tcgtgatgac aaactttctc aaaacagaag      480

gccaagagca gcggttgtgt cccgagtatc ccacccgcag gacgctctgt tcctctgacc      540

gaggttgtaa aaagggatgg atggacccgc agagcaaagg aattcagacc ggaaggtgtg      600

tagtgtatga agggaaccag aagacctgtg aagtctctgc ctggtgcccc atcgaggcag      660

tggaagaggc cccccggcct gctctcttga acagtgccga aaacttcact gtgctcatca      720

agaacaatat cgacttcccc ggccacaact acaccacgag aaacatcctg ccaggtttaa      780

acatcacttg taccttccac aagactcaga atccacagtg tcccattttc cgactaggag      840

acatcttccg agaaacaggc gataattttt cagatgtggc aattcagggc ggaataatgg      900

gcattgagat ctactgggac tgcaacctag accgttggtt ccatcactgc cgtcccaaat      960

acagtttccg tcgccttgac gacaagacca ccaacgtgtc cttgtaccct ggctacaact     1020

tcagatacgc caagtactac aaggaaaaca atgttgagaa acggactctg ataaaagtct     1080

tcgggatccg ttttgacatc ctggtttttg gcaccggagg aaaatttgac attatccagc     1140

tggttgtgta catcggctca accctctcct acttcggtct ggccgctgtg ttcatcgact     1200

tcctcatcga cacttactcc agtaactgct gtcgctccca tatttatccc tggtgcaagt     1260

gctgtcagcc ctgtgtggtc aacgaatact actacaggaa gaagtgcgag tccattgtgg     1320

agccaaagcc gacattaaag tatgtgtcct ttgtggatga atcccacatt aggatggtga     1380

accagcagct actagggaga agtctgcaag atgtcaaggg ccaagaagtc ccaagacctg     1440

cgatggactt cacagatttg tccaggctgc ccctggccct ccatgacaca cccccgattc     1500

ctggacaacc agaggagata cagctgctta gaaaggaggc gactcctaga tccagggata     1560

gccccgtctg gtgccagtgt ggaagctgcc tcccatctca actccctgag agccacaggt     1620

gcctggagga gctgtgctgc cggaaaaagc cgggggcctg catcaccacc tcagagctgt     1680

tcaggaagct ggtcctgtcc agacacgtcc tgcagttcct cctgctctac caggagccct     1740

tgctggcgct ggatgtggat tccaccaaca gccggctgcg gcactgtgcc tacaggtgct     1800

acgccacctg gcgcttcggc tcccaggaca tggctgactt tgccatcctg cccagctgct     1860

gccgctggag gatccggaaa gagtttccga agagtgaagg gcagtacagt ggcttcaaga     1920

gtccttactg aagccaggca ccgtggctca cgtctgtaat cccagcgctt tgggaggccg     1980

aggcaggcag atcacctgag gtcgggagtt ggagacccgc ctggctaaca aggcgaaatc     2040

ctgtctgtac taaaaataca aaaatcagcc agacatggtg gcatgcacct gcaatcccag     2100

ctactcggga ggctgaggca caagaatcac ttgaacccgg gaggcagagg ttgtagtgag     2160

cccagattgt gccactgctc tccagcctgg gaggcacagc aaactgtccc ccaaaaaaaa     2220

aaaagagtcc ttaccaatag caggggctgc agtagccatg ttaacatgac atttaccagc     2280

aacttgaact tcacctgcaa agctctgtgg ccacattttc agccaaaggg aaatatgctt     2340

tcatcttctg ttgctctctg tgtctgagag caaagtgacc tggttaaaca aaccagaatc     2400

cctctacatg gactcagaga aaagagattg agatgtaagt ctcaactctg tccccaggaa     2460

gttgtgtgac cctaggcctc tcacctctgt gcctctgtct ccttgttgcc caactactat     2520

ctcagagata ttgtgaggac aaattgagac agtgcacatg aactgtcttt taatgtgtaa     2580

agatctacat gaatgcaaaa catttcatta tgaggtcaga ctaggataat gtccaactaa     2640

aaacaaaccc ttttcatcct ggctggagaa tgtggagaac taaaggtggc cacaaattct     2700

ttgacactca agtcccccaa gacctaaggg ttttatctcc tccccttgaa tatgggtggc     2760

tctgattgct ttatccaaaa gtggaagtga cattgtgtca gtttcagatc ctgatcttaa     2820

gaggctgaca gcttctactt gctgtccctt ggaactcttg ctatcgggga agccagacgc     2880

catttaaaag tctgcctatc ctggccaggt gtggtggctc acacctgtaa tcccagcact     2940

ttgggagacc aaggcgggcg gatcacttaa agtcaggagt ccaagaccag actcgccaac     3000

atggtgaaac cgtatctcta ataaaaatac aaaaattagc tgggcatggt gcgggcacct     3060

gtagtcctag ctatcaagag gctgagacag gagaaacact tgaacctggg aggtggaggt     3120

tgcattgagc tgagatcgtg ccactgcact ccaggctggg tgacagagcg agactccatc     3180

tcaaaaaaaa aaaaaagaaa aaaaaaatgt ctgcctatcc tgagactgcc ctgctgtgag     3240

gaagcccaag cagtcacgtg gacagtgcct gaccagcccc agctttcaag ccatccaagc     3300

ccagtcacca aacatgagag agaagaagcc ttcaggtgat tctggactcc actaacatat     3360

gactgatacc gcatgataca tcccaagtga gaactgcccc ataaatccag aaaaccacat     3420

tgctatctta agtccctaag tttggggctt atttgttcca cagcaacagg taactggaac     3480

agagggcaag cctgatgaat gggcacacag actcagccca taccttccct ggttctaatg     3540

ttctcaggga gcccggacca accctgggag cctcaggaac ttaggtttcc actggacagt     3600

tctagaaggg ctatagacca aatcaggtaa ctcaccagac cagccttgga atctatcaaa     3660

tctaactgct gagctaccca                                                 3680


<210>  2
<211>  1788
<212>  DNA
<213>  Homo sapiens

<400>  2
atgccggcct gctgcagctg cagtgatgtt ttccagtatg agacgaacaa agtcactcgg       60

atccagagca tgaattatgg caccattaag tggttcttcc acgtgatcat cttttcctac      120

gtttgctttg ctctggtgag tgacaagctg taccagcgga aagagcctgt catcagttct      180

gtgcacacca aggtgaaggg gatagcagag gtgaaagagg agatcgtgga gaatggagtg      240

aagaagttgg tgcacagtgt ctttgacacc gcagactaca ccttcccttt gcaggggaac      300

tctttcttcg tgatgacaaa ctttctcaaa acagaaggcc aagagcagcg gttgtgtccc      360

gagtatccca cccgcaggac gctctgttcc tctgaccgag gttgtaaaaa gggatggatg      420

gacccgcaga gcaaaggaat tcagaccgga aggtgtgtag tgtatgaagg gaaccagaag      480

acctgtgaag tctctgcctg gtgccccatc gaggcagtgg aagaggcccc ccggcctgct      540

ctcttgaaca gtgccgaaaa cttcactgtg ctcatcaaga acaatatcga cttccccggc      600

cacaactaca ccacgagaaa catcctgcca ggtttaaaca tcacttgtac cttccacaag      660

actcagaatc cacagtgtcc cattttccga ctaggagaca tcttccgaga aacaggcgat      720

aatttttcag atgtggcaat tcagggcgga ataatgggca ttgagatcta ctgggactgc      780

aacctagacc gttggttcca tcactgccgt cccaaataca gtttccgtcg ccttgacgac      840

aagaccacca acgtgtcctt gtaccctggc tacaacttca gatacgccaa gtactacaag      900

gaaaacaatg ttgagaaacg gactctgata aaagtcttcg ggatccgttt tgacatcctg      960

gtttttggca ccggaggaaa atttgacatt atccagctgg ttgtgtacat cggctcaacc     1020

ctctcctact tcggtctggc cgctgtgttc atcgacttcc tcatcgacac ttactccagt     1080

aactgctgtc gctcccatat ttatccctgg tgcaagtgct gtcagccctg tgtggtcaac     1140

gaatactact acaggaagaa gtgcgagtcc attgtggagc caaagccgac attaaagtat     1200

gtgtcctttg tggatgaatc ccacattagg atggtgaacc agcagctact agggagaagt     1260

ctgcaagatg tcaagggcca agaagtccca agacctgcga tggacttcac agatttgtcc     1320

aggctgcccc tggccctcca tgacacaccc ccgattcctg gacaaccaga ggagatacag     1380

ctgcttagaa aggaggcgac tcctagatcc agggatagcc ccgtctggtg ccagtgtgga     1440

agctgcctcc catctcaact ccctgagagc cacaggtgcc tggaggagct gtgctgccgg     1500

aaaaagccgg gggcctgcat caccacctca gagctgttca ggaagctggt cctgtccaga     1560

cacgtcctgc agttcctcct gctctaccag gagcccttgc tggcgctgga tgtggattcc     1620

accaacagcc ggctgcggca ctgtgcctac aggtgctacg ccacctggcg cttcggctcc     1680

caggacatgg ctgactttgc catcctgccc agctgctgcc gctggaggat ccggaaagag     1740

tttccgaaga gtgaagggca gtacagtggc ttcaagagtc cttactga                  1788


<210>  3
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Pro Ala Cys Cys Ser Cys Ser Asp Val Phe Gln Tyr Glu Thr Asn 
1               5                   10                  15      


Lys Val Thr Arg Ile Gln Ser Met Asn Tyr Gly Thr Ile Lys Trp Phe 
            20                  25                  30          


Phe His Val Ile Ile Phe Ser Tyr Val Cys Phe Ala Leu Val Ser Asp 
        35                  40                  45              


Lys Leu Tyr Gln Arg Lys Glu Pro Val Ile Ser Ser Val His Thr Lys 
    50                  55                  60                  


Val Lys Gly Ile Ala Glu Val Lys Glu Glu Ile Val Glu Asn Gly Val 
65                  70                  75                  80  


Lys Lys Leu Val His Ser Val Phe Asp Thr Ala Asp Tyr Thr Phe Pro 
                85                  90                  95      


Leu Gln Gly Asn Ser Phe Phe Val Met Thr Asn Phe Leu Lys Thr Glu 
            100                 105                 110         


Gly Gln Glu Gln Arg Leu Cys Pro Glu Tyr Pro Thr Arg Arg Thr Leu 
        115                 120                 125             


Cys Ser Ser Asp Arg Gly Cys Lys Lys Gly Trp Met Asp Pro Gln Ser 
    130                 135                 140                 


Lys Gly Ile Gln Thr Gly Arg Cys Val Val Tyr Glu Gly Asn Gln Lys 
145                 150                 155                 160 


Thr Cys Glu Val Ser Ala Trp Cys Pro Ile Glu Ala Val Glu Glu Ala 
                165                 170                 175     


Pro Arg Pro Ala Leu Leu Asn Ser Ala Glu Asn Phe Thr Val Leu Ile 
            180                 185                 190         


Lys Asn Asn Ile Asp Phe Pro Gly His Asn Tyr Thr Thr Arg Asn Ile 
        195                 200                 205             


Leu Pro Gly Leu Asn Ile Thr Cys Thr Phe His Lys Thr Gln Asn Pro 
    210                 215                 220                 


Gln Cys Pro Ile Phe Arg Leu Gly Asp Ile Phe Arg Glu Thr Gly Asp 
225                 230                 235                 240 


Asn Phe Ser Asp Val Ala Ile Gln Gly Gly Ile Met Gly Ile Glu Ile 
                245                 250                 255     


Tyr Trp Asp Cys Asn Leu Asp Arg Trp Phe His His Cys Arg Pro Lys 
            260                 265                 270         


Tyr Ser Phe Arg Arg Leu Asp Asp Lys Thr Thr Asn Val Ser Leu Tyr 
        275                 280                 285             


Pro Gly Tyr Asn Phe Arg Tyr Ala Lys Tyr Tyr Lys Glu Asn Asn Val 
    290                 295                 300                 


Glu Lys Arg Thr Leu Ile Lys Val Phe Gly Ile Arg Phe Asp Ile Leu 
305                 310                 315                 320 


Val Phe Gly Thr Gly Gly Lys Phe Asp Ile Ile Gln Leu Val Val Tyr 
                325                 330                 335     


Ile Gly Ser Thr Leu Ser Tyr Phe Gly Leu Ala Ala Val Phe Ile Asp 
            340                 345                 350         


Phe Leu Ile Asp Thr Tyr Ser Ser Asn Cys Cys Arg Ser His Ile Tyr 
        355                 360                 365             


Pro Trp Cys Lys Cys Cys Gln Pro Cys Val Val Asn Glu Tyr Tyr Tyr 
    370                 375                 380                 


Arg Lys Lys Cys Glu Ser Ile Val Glu Pro Lys Pro Thr Leu Lys Tyr 
385                 390                 395                 400 


Val Ser Phe Val Asp Glu Ser His Ile Arg Met Val Asn Gln Gln Leu 
                405                 410                 415     


Leu Gly Arg Ser Leu Gln Asp Val Lys Gly Gln Glu Val Pro Arg Pro 
            420                 425                 430         


Ala Met Asp Phe Thr Asp Leu Ser Arg Leu Pro Leu Ala Leu His Asp 
        435                 440                 445             


Thr Pro Pro Ile Pro Gly Gln Pro Glu Glu Ile Gln Leu Leu Arg Lys 
    450                 455                 460                 


Glu Ala Thr Pro Arg Ser Arg Asp Ser Pro Val Trp Cys Gln Cys Gly 
465                 470                 475                 480 


Ser Cys Leu Pro Ser Gln Leu Pro Glu Ser His Arg Cys Leu Glu Glu 
                485                 490                 495     


Leu Cys Cys Arg Lys Lys Pro Gly Ala Cys Ile Thr Thr Ser Glu Leu 
            500                 505                 510         


Phe Arg Lys Leu Val Leu Ser Arg His Val Leu Gln Phe Leu Leu Leu 
        515                 520                 525             


Tyr Gln Glu Pro Leu Leu Ala Leu Asp Val Asp Ser Thr Asn Ser Arg 
    530                 535                 540                 


Leu Arg His Cys Ala Tyr Arg Cys Tyr Ala Thr Trp Arg Phe Gly Ser 
545                 550                 555                 560 


Gln Asp Met Ala Asp Phe Ala Ile Leu Pro Ser Cys Cys Arg Trp Arg 
                565                 570                 575     


Ile Arg Lys Glu Phe Pro Lys Ser Glu Gly Gln Tyr Ser Gly Phe Lys 
            580                 585                 590         


Ser Pro Tyr 
        595 


<210>  4
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Binding peptide

<400>  4

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asn His 
            20                  25                  30          


Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Glu Pro Lys Pro Met Asp Thr Glu Phe Asp Tyr Arg Ser Pro Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  5
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  coding sequence for binding peptide

<400>  5
gaggtccaac tgctggagag tggtgggggt ctcgtacaac cggggggatc tctcaggctc       60

tcatgtgccg cctcaggttt tacattccga aatcatgata tgggctgggt ccgccaagct      120

cctgggaagg ggttggagtg ggtttcagcc atctcaggaa gcggcggctc cacttactac      180

gctgattctg ttaaggggcg attcactata agccgagata atagcaagaa tactctctat      240

cttcagatga actcacttcg ggcggaagac actgcagtct attattgtgc cgaacccaaa      300

cccatggaca cggagttcga ctacagaagc cctgggacct tggttacagt gtctagt         357


<210>  6
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Binding peptide

<400>  6

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asn His 
            20                  25                  30          


Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Glu Pro Lys Pro Met Asp Thr Glu Phe Asp Tyr Trp Ser Pro Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  7
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Binding peptide

<400>  7

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Pro Met Lys 
            20                  25                  30          


Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Glu Pro Lys Pro Met Asp Thr Glu Phe Asp Tyr Arg Ser Pro Gly 
            100                 105                 110         


Thr Leu Val Thr Val Leu Glu 
        115                 


<210>  8
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Binding protein

<400>  8

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asn His 
            20                  25                  30          


Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Glu Pro Lys Pro Met Asp Thr Glu Phe Asp Tyr Pro Ser Pro Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  9
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  9

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  10
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  10

Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
1               5                   10                  15      


Pro Pro Cys Pro 
            20  


<210>  11
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  11

Asn Thr Lys Val Asp Lys Arg Val Glu Leu Lys Thr Pro Leu Gly Asp 
1               5                   10                  15      


Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr 
            20                  25                  30          


Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro 
        35                  40                  45              


Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
    50                  55                  60                  


Pro Cys Pro Arg Cys Pro 
65                  70  


<210>  12
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  12

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro 
1               5                   10          


<210>  13
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  13

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10          


<210>  14
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  14

Pro Val Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr 
1               5                   10                  15      


Pro Ser Pro Ser Cys 
            20      


<210>  15
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  15

Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala Gln Pro Gln 
1               5                   10                  15      


Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala Thr Thr Arg 
            20                  25                  30          


Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu 
        35                  40                  45              


Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro 
    50                  55              


<210>  16
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  16

Ile Ala Glu Leu Pro Pro Lys Val Ser Val Phe Val Pro Pro Arg Asp 
1               5                   10                  15      


Gly Phe Phe Gly Asn Pro Arg Lys Ser Lys Leu Ile Cys Gln Ala Thr 
            20                  25                  30          


Gly Phe Ser Pro Arg Gln Ile Gln Val Ser Trp Leu Arg Glu Gly Lys 
        35                  40                  45              


Gln Val Gly Ser Gly Val Thr Thr Asp Gln Val Gln Ala Glu Ala Lys 
    50                  55                  60                  


Glu Ser Gly Pro Thr Thr Tyr Lys Val Thr Ser Thr Leu Thr Ile Lys 
65                  70                  75                  80  


Glu Ser Asp Trp Leu Gly Gln Ser Met Phe Thr Cys Arg Val Asp His 
                85                  90                  95      


Arg Gly Leu Thr Phe Gln Gln Asn Ala Ser Ser Met Cys Val Pro Asp 
            100                 105                 110         


<210>  17
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  17

Pro Thr Val Lys Ile Leu Gln Ser Ser Cys Asp Gly Gly Gly His Phe 
1               5                   10                  15      


Pro Pro Thr Ile Gln Leu Leu Cys Leu Val Ser Gly Tyr Thr Pro Gly 
            20                  25                  30          


Thr Ile Asn Ile Thr Trp Leu Glu Asp Gly Gln Val Met Asp Val Asp 
        35                  40                  45              


Leu Ser Thr Ala Ser Thr Thr Gln Glu Gly Glu Leu Ala Ser Thr Gln 
    50                  55                  60                  


Ser Glu Leu Thr Leu Ser Gln Lys His Trp Leu Ser Asp Arg Thr Tyr 
65                  70                  75                  80  


Thr Cys Gln Val Thr Tyr Gln Gly His Thr Phe Glu Asp Ser Thr Lys 
                85                  90                  95      


Lys Cys Ala 
            


<210>  18
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  18

Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro 
1               5                   10                  15  


<210>  19
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  19

Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
1               5                   10                  15      


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            20                  25                  30          


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45              


<210>  20
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  20

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  21
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  21

Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro Thr Lys Lys Ser 
1               5                   10                  15      


Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro Glu Thr Gln Lys 
            20                  25                  30          


Gly Pro Leu Cys Ser Pro 
        35              


<210>  22
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  22

Val Asp Phe Leu Pro Thr Thr Ala Gln Pro Thr Lys Lys Ser Thr Leu 
1               5                   10                  15      


Lys Lys Arg Val Cys Arg Leu Pro Arg Pro Glu Thr Gln Lys Gly Pro 
            20                  25                  30          


Leu Cys Ser Pro 
        35      


<210>  23
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  23

Ala Pro Pro Arg Ala Ser Ala Leu Pro Ala Pro Pro Thr Gly Ser Ala 
1               5                   10                  15      


Leu Pro Asp Pro Gln Thr Ala Ser Ala Leu Pro Asp Pro Pro Ala Ala 
            20                  25                  30          


Ser Ala Leu Pro 
        35      


<210>  24
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  24

Asp Ser Gly Gln Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr 
1               5                   10                  15      


Trp Ser Thr Pro Val Gln Pro 
            20              


<210>  25
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PolyG/S hinge

<400>  25

Gly Gly Gly Gly Ser 
1               5   


<210>  26
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  26

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  27
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  27

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  28
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  28

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375         


<210>  29
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  29

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  30
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  30

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  31
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  31

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  32
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  32

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  33
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  33

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  34
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  34

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
            100                 105                 110 


<210>  35
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  35

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            100                 105     


<210>  36
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  36

Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  37
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  37

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
            100                 105         


<210>  38
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker domain

<400>  38

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10          


<210>  39
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  39

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gln Pro Arg 
1               5                   10                  15      


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
            20                  25                  30          


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        35                  40                  45              


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    50                  55                  60                  


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
65                  70                  75                  80  


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
                85                  90                  95      


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            100                 105                 110         


Leu Ser Leu Ser Leu Gly Lys 
        115                 


<210>  40
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  40

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Pro Glu Phe Asp 
1               5                   10                  15      


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln Ser Thr 
65                  70                  75                  80  


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Leu Gly Lys 
225             


<210>  41
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR sequence

<400>  41

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
1               5                   10                  15      


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Asp Pro Lys 
            20                  25                  30  


<210>  42
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  43
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205         


<210>  44
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Gln Leu Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     


Asn Gln Leu Arg 
            180 


<210>  45
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg 
    130                 135                 140                 


Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr 
145                 150                 155                 160 


Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
                165                 170     


<210>  46
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Intracellular CAR domain of CD3 zeta

<400>  46

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  47
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Asp Thr Glu Ser Asn Arg Arg Ala Asn Leu Ala Leu Pro Gln Glu 
1               5                   10                  15      


Pro Ser Ser Val Pro Ala Phe Glu Val Leu Glu Ile Ser Pro Gln Glu 
            20                  25                  30          


Val Ser Ser Gly Arg Leu Leu Lys Ser Ala Ser Ser Pro Pro Leu His 
        35                  40                  45              


Thr Trp Leu Thr Val Leu Lys Lys Glu Gln Glu Phe Leu Gly Val Thr 
    50                  55                  60                  


Gln Ile Leu Thr Ala Met Ile Cys Leu Cys Phe Gly Thr Val Val Cys 
65                  70                  75                  80  


Ser Val Leu Asp Ile Ser His Ile Glu Gly Asp Ile Phe Ser Ser Phe 
                85                  90                  95      


Lys Ala Gly Tyr Pro Phe Trp Gly Ala Ile Phe Phe Ser Ile Ser Gly 
            100                 105                 110         


Met Leu Ser Ile Ile Ser Glu Arg Arg Asn Ala Thr Tyr Leu Val Arg 
        115                 120                 125             


Gly Ser Leu Gly Ala Asn Thr Ala Ser Ser Ile Ala Gly Gly Thr Gly 
    130                 135                 140                 


Ile Thr Ile Leu Ile Ile Asn Leu Lys Lys Ser Leu Ala Tyr Ile His 
145                 150                 155                 160 


Ile His Ser Cys Gln Lys Phe Phe Glu Thr Lys Cys Phe Met Ala Ser 
                165                 170                 175     


Phe Ser Thr Glu Ile Val Val Met Met Leu Phe Leu Thr Ile Leu Gly 
            180                 185                 190         


Leu Gly Ser Ala Val Ser Leu Thr Ile Cys Gly Ala Gly Glu Glu Leu 
        195                 200                 205             


Lys Gly Asn Lys Val Pro Glu Asp Arg Val Tyr Glu Glu Leu Asn Ile 
    210                 215                 220                 


Tyr Ser Ala Thr Tyr Ser Glu Leu Glu Asp Pro Gly Glu Met Ser Pro 
225                 230                 235                 240 


Pro Ile Asp Leu 
                


<210>  48
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Trp Phe Leu Thr Thr Leu Leu Leu Trp Val Pro Val Asp Gly Gln 
1               5                   10                  15      


Val Asp Thr Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val Ser 
            20                  25                  30          


Val Phe Gln Glu Glu Thr Val Thr Leu His Cys Glu Val Leu His Leu 
        35                  40                  45              


Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr Gln 
    50                  55                  60                  


Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp Ser 
65                  70                  75                  80  


Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro Ile 
                85                  90                  95      


Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser Arg 
            100                 105                 110         


Val Phe Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Ala Trp Lys 
        115                 120                 125             


Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn Gly Lys Ala Phe 
    130                 135                 140                 


Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn Ile 
145                 150                 155                 160 


Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg Tyr 
                165                 170                 175     


Thr Ser Ala Gly Ile Ser Val Thr Val Lys Glu Leu Phe Pro Ala Pro 
            180                 185                 190         


Val Leu Asn Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn Leu Val 
        195                 200                 205             


Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro Gly Leu Gln 
    210                 215                 220                 


Leu Tyr Phe Ser Phe Tyr Met Gly Ser Lys Thr Leu Arg Gly Arg Asn 
225                 230                 235                 240 


Thr Ser Ser Glu Tyr Gln Ile Leu Thr Ala Arg Arg Glu Asp Ser Gly 
                245                 250                 255     


Leu Tyr Trp Cys Glu Ala Ala Thr Glu Asp Gly Asn Val Leu Lys Arg 
            260                 265                 270         


Ser Pro Glu Leu Glu Leu Gln Val Leu Gly Leu Gln Leu Pro Thr Pro 
        275                 280                 285             


Val Trp Phe His Val Leu Phe Tyr Leu Ala Val Gly Ile Met Phe Leu 
    290                 295                 300                 


Val Asn Thr Val Leu Trp Val Thr Ile Arg Lys Glu Leu Lys Arg Lys 
305                 310                 315                 320 


Lys Lys Trp Asp Leu Glu Ile Ser Leu Asp Ser Gly His Glu Lys Lys 
                325                 330                 335     


Val Ile Ser Ser Leu Gln Glu Asp Arg His Leu Glu Glu Glu Leu Lys 
            340                 345                 350         


Cys Gln Glu Gln Lys Glu Glu Gln Leu Gln Glu Gly Val His Arg Lys 
        355                 360                 365             


Glu Pro Gln Gly Ala Thr 
    370                 


<210>  49
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR 41BB portion of intracellular domain

<400>  49

Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
1               5                   10                  15      


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
            20                  25                  30          


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40              


<210>  50
<211>  823
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR amino acid sequence

<400>  50

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Arg Asn His Asp Met Gly Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Glu Pro Lys Pro Met Asp Thr Glu Phe 
        115                 120                 125             


Asp Tyr Arg Ser Pro Gly Thr Leu Val Thr Val Ser Ser Glu Ser Lys 
    130                 135                 140                 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gln Pro Arg Glu Pro Gln 
145                 150                 155                 160 


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
                165                 170                 175     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            180                 185                 190         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        195                 200                 205             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
    210                 215                 220                 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
225                 230                 235                 240 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                245                 250                 255     


Ser Leu Gly Lys Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
            260                 265                 270         


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
        275                 280                 285             


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
    290                 295                 300                 


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
305                 310                 315                 320 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
                325                 330                 335     


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
            340                 345                 350         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
        355                 360                 365             


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
    370                 375                 380                 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
385                 390                 395                 400 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
                405                 410                 415     


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
            420                 425                 430         


Ala Leu His Met Gln Ala Leu Pro Pro Arg Leu Glu Gly Gly Gly Glu 
        435                 440                 445             


Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
    450                 455                 460                 


Pro Arg Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro 
465                 470                 475                 480 


His Pro Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly 
                485                 490                 495     


Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys 
            500                 505                 510         


His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro 
        515                 520                 525             


Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro 
    530                 535                 540                 


Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu 
545                 550                 555                 560 


Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu 
                565                 570                 575     


Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser 
            580                 585                 590         


Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu 
        595                 600                 605             


Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu 
    610                 615                 620                 


Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly 
625                 630                 635                 640 


Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala 
                645                 650                 655     


Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly 
            660                 665                 670         


Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg 
        675                 680                 685             


Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe 
    690                 695                 700                 


Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln 
705                 710                 715                 720 


Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln 
                725                 730                 735     


Cys Ala His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala 
            740                 745                 750         


Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala 
        755                 760                 765             


Gly His Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr 
    770                 775                 780                 


Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser 
785                 790                 795                 800 


Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala 
                805                 810                 815     


Leu Gly Ile Gly Leu Phe Met 
            820             


<210>  51
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR amino acid sequence

<400>  51

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Arg Asn His Asp Met Gly Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Glu Pro Lys Pro Met Asp Thr Glu Phe 
        115                 120                 125             


Asp Tyr Arg Ser Pro Gly Thr Leu Val Thr Val Ser Ser Glu Ser Lys 
    130                 135                 140                 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gln Pro Arg Glu Pro Gln 
145                 150                 155                 160 


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
                165                 170                 175     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            180                 185                 190         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        195                 200                 205             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
    210                 215                 220                 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
225                 230                 235                 240 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                245                 250                 255     


Ser Leu Gly Lys Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
            260                 265                 270         


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
        275                 280                 285             


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
    290                 295                 300                 


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
305                 310                 315                 320 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
                325                 330                 335     


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
            340                 345                 350         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
        355                 360                 365             


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
    370                 375                 380                 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
385                 390                 395                 400 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
                405                 410                 415     


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
            420                 425                 430         


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440         


<210>  52
<211>  2478
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coding Sequence for SEQ ID NO 50

<400>  52
gccaccatgc ttctcctggt gacaagcctt ctgctctgtg agttaccaca cccagcattc       60

ctcctgatcc cagaggtcca actgctggag agtggtgggg gtctcgtaca accgggggga      120

tctctcaggc tctcatgtgc cgcctcaggt tttacattcc gaaatcatga tatgggctgg      180

gtccgccaag ctcctgggaa ggggttggag tgggtttcag ccatctcagg aagcggcggc      240

tccacttact acgctgattc tgttaagggg cgattcacta taagccgaga taatagcaag      300

aatactctct atcttcagat gaactcactt cgggcggaag acactgcagt ctattattgt      360

gccgaaccca aacccatgga cacggagttc gactacagaa gccctgggac cttggttaca      420

gtgtctagtg aatctaagta cggaccgccc tgcccccctt gccctggcca gcctagagaa      480

ccccaggtgt acaccctgcc tcccagccag gaagagatga ccaagaacca ggtgtccctg      540

acctgcctgg tcaaaggctt ctaccccagc gatatcgccg tggaatggga gagcaacggc      600

cagcccgaga acaactacaa gaccaccccc cctgtgctgg acagcgacgg cagcttcttc      660

ctgtactccc ggctgaccgt ggacaagagc cggtggcagg aaggcaacgt cttcagctgc      720

agcgtgatgc acgaggccct gcacaaccac tacacccaga agtccctgag cctgagcctg      780

ggcaagatgt tctgggtgct ggtggtggtc ggaggcgtgc tggcctgcta cagcctgctg      840

gtcaccgtgg ccttcatcat cttttgggtg aaacggggca gaaagaaact cctgtatata      900

ttcaaacaac catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc      960

cgatttccag aagaagaaga aggaggatgt gaactgcggg tgaagttcag cagaagcgcc     1020

gacgcccctg cctaccagca gggccagaat cagctgtaca acgagctgaa cctgggcaga     1080

agggaagagt acgacgtcct ggataagcgg agaggccggg accctgagat gggcggcaag     1140

cctcggcgga agaaccccca ggaaggcctg tataacgaac tgcagaaaga caagatggcc     1200

gaggcctaca gcgagatcgg catgaagggc gagcggaggc ggggcaaggg ccacgacggc     1260

ctgtatcagg gcctgtccac cgccaccaag gatacctacg acgccctgca catgcaggcc     1320

ctgcccccaa ggctcgaggg cggcggagag ggcagaggaa gtcttctaac atgcggtgac     1380

gtggaggaga atcccggccc taggatgctt ctcctggtga caagccttct gctctgtgag     1440

ttaccacacc cagcattcct cctgatccca cgcaaagtgt gtaacggaat aggtattggt     1500

gaatttaaag actcactctc cataaatgct acgaatatta aacacttcaa aaactgcacc     1560

tccatcagtg gcgatctcca catcctgccg gtggcattta ggggtgactc cttcacacat     1620

actcctcctc tggatccaca ggaactggat attctgaaaa ccgtaaagga aatcacaggg     1680

tttttgctga ttcaggcttg gcctgaaaac aggacggacc tccatgcctt tgagaaccta     1740

gaaatcatac gcggcaggac caagcaacat ggtcagtttt ctcttgcagt cgtcagcctg     1800

aacataacat ccttgggatt acgctccctc aaggagataa gtgatggaga tgtgataatt     1860

tcaggaaaca aaaatttgtg ctatgcaaat acaataaact ggaaaaaact gtttgggacc     1920

tccggtcaga aaaccaaaat tataagcaac agaggtgaaa acagctgcaa ggccacaggc     1980

caggtctgcc atgccttgtg ctcccccgag ggctgctggg gcccggagcc cagggactgc     2040

gtctcttgcc ggaatgtcag ccgaggcagg gaatgcgtgg acaagtgcaa ccttctggag     2100

ggtgagccaa gggagtttgt ggagaactct gagtgcatac agtgccaccc agagtgcctg     2160

cctcaggcca tgaacatcac ctgcacagga cggggaccag acaactgtat ccagtgtgcc     2220

cactacattg acggccccca ctgcgtcaag acctgcccgg caggagtcat gggagaaaac     2280

aacaccctgg tctggaagta cgcagacgcc ggccatgtgt gccacctgtg ccatccaaac     2340

tgcacctacg gatgcactgg gccaggtctt gaaggctgtc caacgaatgg gcctaagatc     2400

ccgtccatcg ccactgggat ggtgggggcc ctcctcttgc tgctggtggt ggccctgggg     2460

atcggcctct tcatgtga                                                   2478


<210>  53
<211>  1333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coding sequence for SEQ ID NO: 51

<400>  53
cgccaccatg cttctcctgg tgacaagcct tctgctctgt gagttaccac acccagcatt       60

cctcctgatc ccagaggtcc aactgctgga gagtggtggg ggtctcgtac aaccgggggg      120

atctctcagg ctctcatgtg ccgcctcagg ttttacattc cgaaatcatg atatgggctg      180

ggtccgccaa gctcctggga aggggttgga gtgggtttca gccatctcag gaagcggcgg      240

ctccacttac tacgctgatt ctgttaaggg gcgattcact ataagccgag ataatagcaa      300

gaatactctc tatcttcaga tgaactcact tcgggcggaa gacactgcag tctattattg      360

tgccgaaccc aaacccatgg acacggagtt cgactacaga agccctggga ccttggttac      420

agtgtctagt gaatctaagt acggaccgcc ctgcccccct tgccctggcc agcctagaga      480

accccaggtg tacaccctgc ctcccagcca ggaagagatg accaagaacc aggtgtccct      540

gacctgcctg gtcaaaggct tctaccccag cgatatcgcc gtggaatggg agagcaacgg      600

ccagcccgag aacaactaca agaccacccc ccctgtgctg gacagcgacg gcagcttctt      660

cctgtactcc cggctgaccg tggacaagag ccggtggcag gaaggcaacg tcttcagctg      720

cagcgtgatg cacgaggccc tgcacaacca ctacacccag aagtccctga gcctgagcct      780

gggcaagatg ttctgggtgc tggtggtggt cggaggcgtg ctggcctgct acagcctgct      840

ggtcaccgtg gccttcatca tcttttgggt gaaacggggc agaaagaaac tcctgtatat      900

attcaaacaa ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg      960

ccgatttcca gaagaagaag aaggaggatg tgaactgcgg gtgaagttca gcagaagcgc     1020

cgacgcccct gcctaccagc agggccagaa tcagctgtac aacgagctga acctgggcag     1080

aagggaagag tacgacgtcc tggataagcg gagaggccgg gaccctgaga tgggcggcaa     1140

gcctcggcgg aagaaccccc aggaaggcct gtataacgaa ctgcagaaag acaagatggc     1200

cgaggcctac agcgagatcg gcatgaaggg cgagcggagg cggggcaagg gccacgacgg     1260

cctgtatcag ggcctgtcca ccgccaccaa ggatacctac gacgccctgc acatgcaggc     1320

cctgccccca agg                                                        1333


<210>  54
<211>  716
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNA1002 CAR amino acid sequence

<400>  54

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Arg Asn His Asp Met Gly Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Glu Pro Lys Pro Met Asp Thr Glu Phe 
        115                 120                 125             


Asp Tyr Arg Ser Pro Gly Thr Leu Val Thr Val Ser Ser Glu Ser Lys 
    130                 135                 140                 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Met Phe Trp Val Leu Val Val 
145                 150                 155                 160 


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
                165                 170                 175     


Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
            180                 185                 190         


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
        195                 200                 205             


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
    210                 215                 220                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
225                 230                 235                 240 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                245                 250                 255     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            260                 265                 270         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        275                 280                 285             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    290                 295                 300                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
305                 310                 315                 320 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Leu 
                325                 330                 335     


Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
            340                 345                 350         


Glu Glu Asn Pro Gly Pro Arg Met Leu Leu Leu Val Thr Ser Leu Leu 
        355                 360                 365             


Leu Cys Glu Leu Pro His Pro Ala Phe Leu Leu Ile Pro Arg Lys Val 
    370                 375                 380                 


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
385                 390                 395                 400 


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
                405                 410                 415     


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
            420                 425                 430         


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
        435                 440                 445             


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
    450                 455                 460                 


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
465                 470                 475                 480 


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
                485                 490                 495     


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
            500                 505                 510         


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
        515                 520                 525             


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
    530                 535                 540                 


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
545                 550                 555                 560 


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
                565                 570                 575     


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
            580                 585                 590         


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
        595                 600                 605             


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
    610                 615                 620                 


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
625                 630                 635                 640 


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
                645                 650                 655     


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
            660                 665                 670         


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
        675                 680                 685             


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
    690                 695                 700                 


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met 
705                 710                 715     


<210>  55
<211>  2158
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coding DNA for SEQ ID NO:54

<400>  55
cgccaccatg cttctcctgg tgacaagcct tctgctctgt gagttaccac acccagcatt       60

cctcctgatc ccagaggtcc aactgctgga gagtggtggg ggtctcgtac aaccgggggg      120

atctctcagg ctctcatgtg ccgcctcagg ttttacattc cgaaatcatg atatgggctg      180

ggtccgccaa gctcctggga aggggttgga gtgggtttca gccatctcag gaagcggcgg      240

ctccacttac tacgctgatt ctgttaaggg gcgattcact ataagccgag ataatagcaa      300

gaatactctc tatcttcaga tgaactcact tcgggcggaa gacactgcag tctattattg      360

tgccgaaccc aaacccatgg acacggagtt cgactacaga agccctggga ccttggttac      420

agtgtctagt gaatctaagt acggaccgcc ctgcccccct tgccctatgt tctgggtgct      480

ggtggtggtc ggaggcgtgc tggcctgcta cagcctgctg gtcaccgtgg ccttcatcat      540

cttttgggtg aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag      600

accagtacaa actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga      660

aggaggatgt gaactgcggg tgaagttcag cagaagcgcc gacgcccctg cctaccagca      720

gggccagaat cagctgtaca acgagctgaa cctgggcaga agggaagagt acgacgtcct      780

ggataagcgg agaggccggg accctgagat gggcggcaag cctcggcgga agaaccccca      840

ggaaggcctg tataacgaac tgcagaaaga caagatggcc gaggcctaca gcgagatcgg      900

catgaagggc gagcggaggc ggggcaaggg ccacgacggc ctgtatcagg gcctgtccac      960

cgccaccaag gatacctacg acgccctgca catgcaggcc ctgcccccaa ggctcgaggg     1020

cggcggagag ggcagaggaa gtcttctaac atgcggtgac gtggaggaga atcccggccc     1080

taggatgctt ctcctggtga caagccttct gctctgtgag ttaccacacc cagcattcct     1140

cctgatccca cgcaaagtgt gtaacggaat aggtattggt gaatttaaag actcactctc     1200

cataaatgct acgaatatta aacacttcaa aaactgcacc tccatcagtg gcgatctcca     1260

catcctgccg gtggcattta ggggtgactc cttcacacat actcctcctc tggatccaca     1320

ggaactggat attctgaaaa ccgtaaagga aatcacaggg tttttgctga ttcaggcttg     1380

gcctgaaaac aggacggacc tccatgcctt tgagaaccta gaaatcatac gcggcaggac     1440

caagcaacat ggtcagtttt ctcttgcagt cgtcagcctg aacataacat ccttgggatt     1500

acgctccctc aaggagataa gtgatggaga tgtgataatt tcaggaaaca aaaatttgtg     1560

ctatgcaaat acaataaact ggaaaaaact gtttgggacc tccggtcaga aaaccaaaat     1620

tataagcaac agaggtgaaa acagctgcaa ggccacaggc caggtctgcc atgccttgtg     1680

ctcccccgag ggctgctggg gcccggagcc cagggactgc gtctcttgcc ggaatgtcag     1740

ccgaggcagg gaatgcgtgg acaagtgcaa ccttctggag ggtgagccaa gggagtttgt     1800

ggagaactct gagtgcatac agtgccaccc agagtgcctg cctcaggcca tgaacatcac     1860

ctgcacagga cggggaccag acaactgtat ccagtgtgcc cactacattg acggccccca     1920

ctgcgtcaag acctgcccgg caggagtcat gggagaaaac aacaccctgg tctggaagta     1980

cgcagacgcc ggccatgtgt gccacctgtg ccatccaaac tgcacctacg gatgcactgg     2040

gccaggtctt gaaggctgtc caacgaatgg gcctaagatc ccgtccatcg ccactgggat     2100

ggtgggggcc ctcctcttgc tgctggtggt ggccctgggg atcggcctct tcatgtga       2158


<210>  56
<211>  932
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNA1004 CAR amino acid sequence

<400>  56

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Arg Asn His Asp Met Gly Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Glu Pro Lys Pro Met Asp Thr Glu Phe 
        115                 120                 125             


Asp Tyr Arg Ser Pro Gly Thr Leu Val Thr Val Ser Ser Glu Ser Lys 
    130                 135                 140                 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Pro Glu Phe Asp Gly Gly Pro 
145                 150                 155                 160 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                165                 170                 175     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
            180                 185                 190         


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        195                 200                 205             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln Ser Thr Tyr Arg Val 
    210                 215                 220                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
225                 230                 235                 240 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
                245                 250                 255     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            260                 265                 270         


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        275                 280                 285             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    290                 295                 300                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
305                 310                 315                 320 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
                325                 330                 335     


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            340                 345                 350         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        355                 360                 365             


Lys Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
    370                 375                 380                 


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly 
385                 390                 395                 400 


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
                405                 410                 415     


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
            420                 425                 430         


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
        435                 440                 445             


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
    450                 455                 460                 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
465                 470                 475                 480 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
                485                 490                 495     


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
            500                 505                 510         


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
        515                 520                 525             


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
    530                 535                 540                 


Met Gln Ala Leu Pro Pro Arg Leu Glu Gly Gly Gly Glu Gly Arg Gly 
545                 550                 555                 560 


Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Arg Met 
                565                 570                 575     


Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala 
            580                 585                 590         


Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu 
        595                 600                 605             


Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys 
    610                 615                 620                 


Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe 
625                 630                 635                 640 


Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu 
                645                 650                 655     


Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln 
            660                 665                 670         


Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu 
        675                 680                 685             


Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val 
    690                 695                 700                 


Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile 
705                 710                 715                 720 


Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala 
                725                 730                 735     


Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr 
            740                 745                 750         


Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln 
        755                 760                 765             


Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro 
    770                 775                 780                 


Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val 
785                 790                 795                 800 


Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn 
                805                 810                 815     


Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn 
            820                 825                 830         


Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His 
        835                 840                 845             


Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met 
    850                 855                 860                 


Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val 
865                 870                 875                 880 


Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly 
                885                 890                 895     


Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr 
            900                 905                 910         


Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile 
        915                 920                 925             


Gly Leu Phe Met 
    930         


<210>  57
<211>  2809
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coding DNA for SEQ ID NO:56

<400>  57
cgccaccatg cttctcctgg tgacaagcct tctgctctgt gagttaccac acccagcatt       60

cctcctgatc ccagaggtcc aactgctgga gagtggtggg ggtctcgtac aaccgggggg      120

atctctcagg ctctcatgtg ccgcctcagg ttttacattc cgaaatcatg atatgggctg      180

ggtccgccaa gctcctggga aggggttgga gtgggtttca gccatctcag gaagcggcgg      240

ctccacttac tacgctgatt ctgttaaggg gcgattcact ataagccgag ataatagcaa      300

gaatactctc tatcttcaga tgaactcact tcgggcggaa gacactgcag tctattattg      360

tgccgaaccc aaacccatgg acacggagtt cgactacaga agccctggga ccttggttac      420

agtgtctagt gaatctaagt acggaccgcc ctgcccccct tgccctgccc ccgagttcga      480

cggcggaccc agcgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagccg      540

gacccccgag gtgacctgcg tggtggtgga cgtgagccag gaagatcccg aggtccagtt      600

caattggtac gtggacggcg tggaagtgca caacgccaag accaagccca gagaggaaca      660

gttccagagc acctaccggg tggtgtctgt gctgaccgtg ctgcaccagg actggctgaa      720

cggcaaagaa tacaagtgca aggtgtccaa caagggcctg cccagcagca tcgaaaagac      780

catcagcaag gccaagggcc agcctcgcga gccccaggtg tacaccctgc ctccctccca      840

ggaagagatg accaagaacc aggtgtccct gacctgcctg gtgaagggct tctaccccag      900

cgacatcgcc gtggagtggg agagcaacgg ccagcctgag aacaactaca agaccacccc      960

tcccgtgctg gacagcgacg gcagcttctt cctgtacagc cggctgaccg tggacaagag     1020

ccggtggcag gaaggcaacg tctttagctg cagcgtgatg cacgaggccc tgcacaacca     1080

ctacacccag aagagcctga gcctgtccct gggcaagatg ttctgggtgc tggtggtggt     1140

gggcggggtg ctggcctgct acagcctgct ggtgacagtg gccttcatca tcttttgggt     1200

gaaacggggc agaaagaaac tcctgtatat attcaaacaa ccatttatga gaccagtaca     1260

aactactcaa gaggaagatg gctgtagctg ccgatttcca gaagaagaag aaggaggatg     1320

tgaactgcgg gtgaagttca gcagaagcgc cgacgcccct gcctaccagc agggccagaa     1380

tcagctgtac aacgagctga acctgggcag aagggaagag tacgacgtcc tggataagcg     1440

gagaggccgg gaccctgaga tgggcggcaa gcctcggcgg aagaaccccc aggaaggcct     1500

gtataacgaa ctgcagaaag acaagatggc cgaggcctac agcgagatcg gcatgaaggg     1560

cgagcggagg cggggcaagg gccacgacgg cctgtatcag ggcctgtcca ccgccaccaa     1620

ggatacctac gacgccctgc acatgcaggc cctgccccca aggctcgagg gcggcggaga     1680

gggcagagga agtcttctaa catgcggtga cgtggaggag aatcccggcc ctaggatgct     1740

tctcctggtg acaagccttc tgctctgtga gttaccacac ccagcattcc tcctgatccc     1800

acgcaaagtg tgtaacggaa taggtattgg tgaatttaaa gactcactct ccataaatgc     1860

tacgaatatt aaacacttca aaaactgcac ctccatcagt ggcgatctcc acatcctgcc     1920

ggtggcattt aggggtgact ccttcacaca tactcctcct ctggatccac aggaactgga     1980

tattctgaaa accgtaaagg aaatcacagg gtttttgctg attcaggctt ggcctgaaaa     2040

caggacggac ctccatgcct ttgagaacct agaaatcata cgcggcagga ccaagcaaca     2100

tggtcagttt tctcttgcag tcgtcagcct gaacataaca tccttgggat tacgctccct     2160

caaggagata agtgatggag atgtgataat ttcaggaaac aaaaatttgt gctatgcaaa     2220

tacaataaac tggaaaaaac tgtttgggac ctccggtcag aaaaccaaaa ttataagcaa     2280

cagaggtgaa aacagctgca aggccacagg ccaggtctgc catgccttgt gctcccccga     2340

gggctgctgg ggcccggagc ccagggactg cgtctcttgc cggaatgtca gccgaggcag     2400

ggaatgcgtg gacaagtgca accttctgga gggtgagcca agggagtttg tggagaactc     2460

tgagtgcata cagtgccacc cagagtgcct gcctcaggcc atgaacatca cctgcacagg     2520

acggggacca gacaactgta tccagtgtgc ccactacatt gacggccccc actgcgtcaa     2580

gacctgcccg gcaggagtca tgggagaaaa caacaccctg gtctggaagt acgcagacgc     2640

cggccatgtg tgccacctgt gccatccaaa ctgcacctac ggatgcactg ggccaggtct     2700

tgaaggctgt ccaacgaatg ggcctaagat cccgtccatc gccactggga tggtgggggc     2760

cctcctcttg ctgctggtgg tggccctggg gatcggcctc ttcatgtga                 2809


<210>  58
<211>  1260
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coding sequence BLIV-CAR short hinge CAR

<400>  58
gaccggcgcc tactctagag gagcgcgtca tggccctgcc tgtgacagcc ctgctgctgc       60

cactcgctct tctccttcac gccgcaagac ccgaagtgca gcttctggag tctggaggtg      120

gtttggtgca gcctggcggg tctctcagat tgtcatgcgc cgcatccggt ttcacctttc      180

ggaaccatga tatgggttgg gtccgccagg ccccaggcaa gggtcttgag tgggtctccg      240

ccatcagcgg cagtggcggg tccacatact acgcagactc cgtcaaaggc agatttacaa      300

tttcacggga taatagtaag aacactctgt acctccagat gaatagtctc cgggcggagg      360

acacagctgt gtactattgc gcggagccaa agccaatgga tactgagttt gattattgga      420

gcccgggaac cctggtgaca gtatccagcg gcggcggcgg ctctggcggt gggggtagcg      480

gaggcggcgg aagcgaatcc aaatatggcc ctccttgtcc accgtgcccc gatccaaagt      540

tctgggtgct ggtggtagtg ggtggcgtcc tggcctgtta ttctctgctt gtgacagtcg      600

cgtttatcat cttttgggtc cggtctaaac gctctaggtt gttgcactcc gattacatga      660

acatgacccc acgccggcct ggccctacgc ggaagcacta ccaaccttac gctcctccca      720

gggatttcgc cgcttacagg agccgagatc agagactgcc acccgatgca cacaaaccac      780

ccggtggtgg gtctttcagg accccaatcc aggaggagca agctgacgcg cattccaccc      840

ttgccaagat aagggtcaaa tttagtaggt cagctgacgc gccggcctat caacagggac      900

agaaccagtt gtataatgaa ctcaatctcg gacgacgcga ggagtacgac gtactggata      960

agaggcgcgg cagggatcct gaaatgggcg gcaagccccg gcgaaaaaac ccccaggagg     1020

gactctacaa tgagctgcag aaggacaaaa tggcagaagc ttactccgaa attggaatga     1080

agggcgaaag aaggagaggg aaagggcacg atggcctgta tcagggcctg agtaccgcca     1140

ccaaggacac gtatgatgcc ctgcatatgc aggcactgcc ccctagagga agcggggcta     1200

cgaatttcag cctcctgaaa caggctggcg acgtggagga aaatccgggg ccaggcgaat     1260


<210>  59
<211>  1875
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coding sequence BLIV-CAR long hinge CAR

<400>  59
gaccggcgcc tactctagag gagcgcgtca tggctcttcc tgtgaccgca ttgctgctgc       60

cgctggcctt gctgctgcat gcagctcggc cagaagttca actgctggag agtggagggg      120

gcctcgtgca gccgggcggc agcttgcgcc tgtcatgtgc agcaagcggg ttcaccttta      180

ggaaccacga tatggggtgg gtgaggcagg ctccgggaaa gggtctggaa tgggtgagtg      240

ccatatcagg gagcggaggc tccacctact acgcagactc cgtgaagggt cggtttacga      300

tttccagaga caattccaag aataccctgt acctgcagat gaactccctc cgcgccgaag      360

atacagcagt ctactactgt gcagaaccaa aaccaatgga tacagaattc gactattgga      420

gtcctggaac tcttgtcact gtatccagtg gaggaggcga gagtaaatat ggacctccgt      480

gtccgagttg tcccgcgcct cctgtggccg gcccctctgt atttctgttt ccacctaagc      540

cgaaagatac attgatgatt agccgaacac cagaggttac ttgtgtggtt gttgacgtga      600

gtcaagagga ccctgaggtg cagtttaatt ggtatgtcga cggagttgag gtgcataacg      660

ccaagacgaa gccgcgagag gagcagttta attccaccta cagggtcgta tccgttctca      720

ctgtccttca ccaggactgg ctgaatggga aggagtacaa atgcaaagtg agcaataaag      780

gcctgccgag ctccatcgaa aaaaccattt ccaaggcaaa aggccaaccc cgagagccac      840

aggtctatac cctgccacca agccaggagg aaatgaccaa gaatcaggtg agcctcacct      900

gtctggtcaa gggcttctac ccgtccgaca tcgcggtgga gtgggagagt aacggacagc      960

ctgaaaacaa ttacaagaca accccgcctg ttttggactc tgacggctcc ttttttctgt     1020

actctcggct taccgtggat aagagtagat ggcaagaagg caacgtcttc agctgttccg     1080

tgatgcatga ggcgctgcat aaccattata cacaaaaaag tctgtccttg agcctgggca     1140

aattttgggt gctggtggtg gtggggggtg tcctcgcttg ctacagtttg ttggtgacag     1200

ttgcctttat tattttttgg gtgcgcagta agcggagtcg cctccttcat tccgactata     1260

tgaacatgac acctcgccgc ccaggcccaa cgaggaaaca ttatcagcca tatgcaccac     1320

ctagagactt tgccgcttac cggtcccgag atcaaaggct tccccccgat gcacacaaac     1380

cacccggcgg tggctcattt cgaacaccaa ttcaggaaga gcaggcagac gcccacagca     1440

ccctggccaa gatccgggta aagttcagcc gaagtgcaga tgcgccggca taccagcagg     1500

gccagaatca attgtacaat gagcttaacc tcggccgcag agaggagtat gatgtactgg     1560

ataagcggcg cggacgggat cctgagatgg gaggaaagcc tcggagaaaa aatccccagg     1620

aaggacttta caatgagttg cagaaggata agatggccga agcatattct gaaatcggga     1680

tgaaaggtga gcggcggaga ggaaaaggcc acgacgggct ctaccagggg ctgagcacag     1740

ctactaaaga tacatacgac gcacttcata tgcaagccct gcctccccgc ggaagcggtg     1800

ccacgaactt ttctctcctc aaacaggctg gggacgtcga ggaaaatcca ggtcccggcg     1860

aattcgccac catgc                                                      1875


<210>  60
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BLIV-CAR short amino acid sequence

<400>  60

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Arg Asn His Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Glu Pro Lys Pro Met Asp Thr Glu Phe Asp 
        115                 120                 125             


Tyr Trp Ser Pro Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ser Lys Tyr Gly 
145                 150                 155                 160 


Pro Pro Cys Pro Pro Cys Pro Asp Pro Lys Phe Trp Val Leu Val Val 
                165                 170                 175     


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
            180                 185                 190         


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
        195                 200                 205             


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
    210                 215                 220                 


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Asp 
225                 230                 235                 240 


Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe 
                245                 250                 255     


Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala 
            260                 265                 270         


Lys Ile Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
        275                 280                 285             


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
    290                 295                 300                 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
305                 310                 315                 320 


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
                325                 330                 335     


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
            340                 345                 350         


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
        355                 360                 365             


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
    370                 375                 380                 


Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
385                 390                 395                 400 


Asp Val Glu Glu Asn Pro Gly Pro 
                405             


<210>  61
<211>  611
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BLIV-CAR long hinge CAR amino acid sequence

<400>  61

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Arg Asn His Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Glu Pro Lys Pro Met Asp Thr Glu Phe Asp 
        115                 120                 125             


Tyr Trp Ser Pro Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Glu 
    130                 135                 140                 


Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Pro Val Ala 
145                 150                 155                 160 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                165                 170                 175     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            180                 185                 190         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        195                 200                 205             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
    210                 215                 220                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
225                 230                 235                 240 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
                245                 250                 255     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            260                 265                 270         


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
        275                 280                 285             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    290                 295                 300                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
305                 310                 315                 320 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
                325                 330                 335     


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
            340                 345                 350         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        355                 360                 365             


Leu Gly Lys Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
    370                 375                 380                 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
385                 390                 395                 400 


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
                405                 410                 415     


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
            420                 425                 430         


Asp Phe Ala Ala Tyr Arg Ser Arg Asp Gln Arg Leu Pro Pro Asp Ala 
        435                 440                 445             


His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu 
    450                 455                 460                 


Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Arg Val Lys Phe Ser 
465                 470                 475                 480 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
                485                 490                 495     


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
            500                 505                 510         


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
        515                 520                 525             


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
    530                 535                 540                 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
545                 550                 555                 560 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
                565                 570                 575     


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr 
            580                 585                 590         


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
        595                 600                 605             


Pro Gly Glu 
    610     


<210>  62
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFRt amino acid sequence

<400>  62

Arg Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His 
1               5                   10                  15      


Pro Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile 
            20                  25                  30          


Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His 
        35                  40                  45              


Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val 
    50                  55                  60                  


Ala Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln 
65                  70                  75                  80  


Glu Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu 
                85                  90                  95      


Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn 
            100                 105                 110         


Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu 
        115                 120                 125             


Ala Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys 
    130                 135                 140                 


Glu Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys 
145                 150                 155                 160 


Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln 
                165                 170                 175     


Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr 
            180                 185                 190         


Gly Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro 
        195                 200                 205             


Glu Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu 
    210                 215                 220                 


Cys Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val 
225                 230                 235                 240 


Glu Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala 
                245                 250                 255     


Met Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys 
            260                 265                 270         


Ala His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly 
        275                 280                 285             


Val Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly 
    290                 295                 300                 


His Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly 
305                 310                 315                 320 


Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile 
                325                 330                 335     


Ala Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu 
            340                 345                 350         


Gly Ile Gly Leu Phe Met 
        355             


<210>  63
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BLIV-CAR Long linker domain

<400>  63

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln Ser Thr 
65                  70                  75                  80  


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Leu Gly Lys 
225             


<210>  64
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Binding peptide

<400>  64

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Pro Met Lys 
            20                  25                  30          


Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Glu Pro Lys Pro Met Asp Thr Glu Phe Asp Tyr Arg Ser Pro Gly 
            100                 105                 110         


Thr Leu Val Thr Val Leu Glu 
        115                 


<210>  65
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Binding peptide

<400>  65

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asn His 
            20                  25                  30          


Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Glu Pro Lys Pro Met Asp Thr Glu Phe Asp Tyr Pro Ser Pro Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  66
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Binding peptide

<400>  66

Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Asp Ser Gly Gly Tyr Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Arg Asn Thr Leu Ser 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ser Thr Ser Leu Val Glu Phe Phe Asp Tyr Trp Gly Pro Gly Thr Ala 
            100                 105                 110         


Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Asn Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val 
145                 150                 155                 160 


Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln 
                165                 170                 175     


Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Val His Ser Asn Gly 
            180                 185                 190         


Asn Thr Tyr Leu Glu Trp Tyr Leu Lys Lys Pro Gly Gln Ser Pro Lys 
        195                 200                 205             


Leu Leu Ile Tyr Lys Val Ser Tyr Arg Phe Ser Gly Val Pro Asp Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg 
225                 230                 235                 240 


Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly Ser Leu 
                245                 250                 255     


Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Gln Arg Ala 
            260                 265                 270         


Asp Ala Ala Pro Thr Val Ser 
        275                 


<210>  67
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Binding peptide

<400>  67

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asn His 
            20                  25                  30          


Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Glu Pro Lys Pro Met Asp Thr Glu Phe Asp Tyr Pro Ser Pro Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Arg Ala Asp Ala Ala Pro Thr Val Ser Ile 
        115                 120                 125             


Phe Pro Pro Ser Ser Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu 
145                 150                 155                 160 


Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln 
                165                 170                 175     


Asn Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Lys 
            180                 185                 190         


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Tyr Arg 
        195                 200                 205             


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
225                 230                 235                 240 


Tyr Cys Phe Gln Gly Ser Leu Val Pro Trp Thr Phe Gly Gly Gly Thr 
                245                 250                 255     


Lys Leu Glu Ile Gln Arg Ala Asp Ala Ala Pro Thr Val Ser 
            260                 265                 270 


<210>  68
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Binding peptide

<400>  68

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Pro Met Lys 
            20                  25                  30          


Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Glu Pro Lys Pro Met Asp Thr Glu Phe Asp Tyr Arg Ser Pro Gly 
            100                 105                 110         


Thr Leu Val Thr Val Leu Glu Arg Ala Asp Ala Ala Pro Thr Val Ser 
        115                 120                 125             


Ile Phe Pro Pro Ser Ser Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
145                 150                 155                 160 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                165                 170                 175     


Phe Thr Phe Arg Asn His Asp Met Gly Trp Val Arg Gln Ala Pro Gly 
            180                 185                 190         


Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr 
        195                 200                 205             


Tyr Tyr Ala Asn Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    210                 215                 220                 


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Ala Glu Pro Lys Pro Met Asp Thr Glu Phe 
                245                 250                 255     


Asp Tyr Pro Ser Pro Gly Thr Leu Val Thr Val Ser 
            260                 265             


<210>  69
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coupling region for multivalent CARs

<400>  69

Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Asn 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30      


