                         SEQUENCE LISTING

<110>  ETH Zurich
 
<120>  TOMM6-interacting extracts and compounds for use in the treatment
        and prophylaxis of nervous system diseases

<130>  50676PCT

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ser Ser Thr Val Pro Val Ser Ala Ala Gly Ser Ala Asn Glu 
1               5                   10                  15      


Thr Pro Glu Ile Pro Asp Asn Val Gly Asp Trp Leu Arg Gly Val Tyr 
            20                  25                  30          


Arg Phe Ala Thr Asp Arg Asn Asp Phe Arg Arg Asn Leu Ile Leu Asn 
        35                  40                  45              


Leu Gly Leu Phe Ala Ala Gly Val Trp Leu Ala Arg Asn Leu Ser Asp 
    50                  55                  60                  


Ile Asp Leu Met Ala Pro Gln Pro Gly Val 
65                  70                  


<210>  2
<211>  74
<212>  PRT
<213>  Mus musculus

<400>  2

Met Ala Ser Ser Gly Val Thr Val Ser Ala Ala Gly Ser Ala Ser Glu 
1               5                   10                  15      


Ala Ser Glu Val Pro Asp Asn Val Gly Asp Trp Leu Arg Gly Val Phe 
            20                  25                  30          


Arg Phe Ala Thr Asp Arg Asn Asp Phe Arg Arg Asn Leu Ile Leu Asn 
        35                  40                  45              


Leu Gly Leu Phe Ala Ala Gly Val Trp Leu Ala Arg Asn Leu Ser Asp 
    50                  55                  60                  


Ile Asp Leu Met Ala Pro Gln Pro Gly Val 
65                  70                  


<210>  3
<211>  63
<212>  PRT
<213>  Danio rerio

<400>  3

Met Ser Gly Lys Lys Ser Glu Gly Lys Ser Gly Gly Val Thr Gly Trp 
1               5                   10                  15      


Ile Ser Ser Ala Cys Arg Phe Ala Ala Asp Arg Asn Asp Phe Arg Arg 
            20                  25                  30          


Asn Leu Leu Val Asn Leu Gly Leu Phe Ala Ala Gly Val Trp Val Ala 
        35                  40                  45              


Arg Asn Leu Ser Asp Phe Asp Leu Met Ser Pro Gln Pro Val Thr 
    50                  55                  60              


<210>  4
<211>  74
<212>  PRT
<213>  Mus musculus

<400>  4

Met Ala Ser Ser Gly Val Thr Val Ser Ala Ala Gly Ser Ala Ser Glu 
1               5                   10                  15      


Ala Ser Glu Val Pro Asp Asn Val Gly Asp Trp Leu Arg Gly Val Phe 
            20                  25                  30          


Arg Phe Ala Thr Asp Arg Asn Asp Phe Arg Arg Asn Leu Ile Leu Asn 
        35                  40                  45              


Leu Gly Leu Phe Ala Ala Gly Val Trp Leu Ala Arg Asn Leu Ser Asp 
    50                  55                  60                  


Ile Asp Leu Met Ala Pro Gln Pro Gly Val 
65                  70                  


<210>  5
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  5

Asn Leu Ser Asp Ile Asp Leu Met Ala Pro Gln Pro Gly Val 
1               5                   10                  


<210>  6
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide sequence of mouse TOMM6 with oxidized M


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  oxidized

<400>  6

Asn Leu Ser Asp Ile Asp Leu Met Ala Pro Gln Pro Gly Val 
1               5                   10                  


<210>  7
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Partial peptide sequence of mouse TOMM6 with oxidized M


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  oxidized

<400>  7

Arg Asn Leu Ser Asp Ile Asp Leu Met Ala Pro Gln Pro Gly Val 
1               5                   10                  15  


<210>  8
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Partial sequence of vector pcDNA3.1 carrying the human TOMM6 gene

<400>  8
ccactagtaa cggccgccag tgtgctggaa ttcatggctt ccagcactgt cccggtgagc       60

gctgctggct cggctaatga aactcccgaa ataccggaca acgtgggaga ttggcttcgg      120

ggcgtctacc gctttgccac tgataggaat gacttccgga ggaacttgat actaaatttg      180

ggactctttg ctgcgggagt ttggctggcc aggaacttga gtgacattga cctcatggca      240

cctcagccag gggtgtagct cgagcatgca tctagagggc cctattctat agtgtcacct      300

aaatgctaga gctcgctgat cagcctcgac tgtgccttct agttgcca                   348


<210>  9
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer TOMM6 forward

<400>  9
tatttagaat tcatggcttc cagcactgtc ccgg                                   34


<210>  10
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer TOMM6 reverse

<400>  10
tatttactcg agctacaccc ctggctgagg tgcc                                   34


<210>  11
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer TOMM6-internal forward

<400>  11
ggtgagcgct gctggctcgg ctaatgaaac                                        30


<210>  12
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer pcDNA3-reverse

<400>  12
tagaaggcac agtcgaggct gatcagcgag                                        30


<210>  13
<211>  429
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Partial sequence of vector CosSHa.Tet carrying the human TOMM6 
       gene

<400>  13
gtcacacatt tgttctgcaa cagatgtcaa gtgcttcagc ctgcgtgctg gacaatgacg       60

tgttgctgga gtacaatgat gccttgttct tcattttgca gatcagtcga caccatggct      120

tccagcactg tcccggtgag cgctgctggc tcggctaatg aaactcccga aataccggac      180

aacgtgggag attggcttcg gggcgtctac cgctttgcca ctgataggaa tgacttccgg      240

aggaacttga tactaaattt gggactcttt gctgcgggag tttggctggc caggaacttg      300

agtgacattg acctcatggc acctcagcca ggggtgtagg tcgacctccc tgcttgtact      360

tcctcgttct tgtggtctag gctgggggag gggttatcca ccgtagctct tttaattgag      420

gtggtggct                                                              429


<210>  14
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer CosSHa.Tet-forward

<400>  14
gcttcagcct gcgtgctgga caatgacgtg                                        30


<210>  15
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer TOMM6-reverse

<400>  15
cctggctgag gtgccatgag gtcaatgtca c                                      31


<210>  16
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer Prp-forward

<400>  16
aagcggccaa agcctggagg gtggaaca                                          28


<210>  17
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer APP-forward

<400>  17
ctgaccactc gaccaggttc tgggt                                             25


<210>  18
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer Prp-reverse

<400>  18
gtggataacc cctcccccag cctagacca                                         29


