                         SEQUENCE LISTING

<110>  New York University
 
<120>  TREATMENT OF MELANOMA BRAIN METASTASIS BY INHIBITION OF AMYLOID 
       PRECURSOR PROTEIN CLEAVAGE

<130>  058636.00202

<150>  62/674,417
<151>  2018-05-21

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  1

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val 
        35                  40  


<210>  2
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  2

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          


<210>  3
<211>  670
<212>  PRT
<213>  Homo sapiens

<400>  3

Leu Glu Val Pro Thr Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro Gln 
1               5                   10                  15      


Ile Ala Met Phe Cys Gly Arg Leu Asn Met His Met Asn Val Gln Asn 
            20                  25                  30          


Gly Lys Trp Asp Ser Asp Pro Ser Gly Thr Lys Thr Cys Ile Asp Thr 
        35                  40                  45              


Lys Glu Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu Gln 
    50                  55                  60                  


Ile Thr Asn Val Val Glu Ala Asn Gln Pro Val Thr Ile Gln Asn Trp 
65                  70                  75                  80  


Cys Lys Arg Gly Arg Lys Gln Cys Lys Thr His Pro His Phe Val Ile 
                85                  90                  95      


Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu Val 
            100                 105                 110         


Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys Glu 
        115                 120                 125             


Thr His Leu His Trp His Thr Val Ala Lys Glu Thr Cys Ser Glu Lys 
    130                 135                 140                 


Ser Thr Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile Asp 
145                 150                 155                 160 


Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu Ser 
                165                 170                 175     


Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val Trp 
            180                 185                 190         


Trp Gly Gly Ala Asp Thr Asp Tyr Ala Asp Gly Ser Glu Asp Lys Val 
        195                 200                 205             


Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu Glu 
    210                 215                 220                 


Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu Glu 
225                 230                 235                 240 


Ala Glu Glu Pro Tyr Glu Glu Ala Thr Glu Arg Thr Thr Ser Ile Ala 
                245                 250                 255     


Thr Thr Thr Thr Thr Thr Thr Glu Ser Val Glu Glu Val Val Arg Glu 
            260                 265                 270         


Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Met Ile Ser 
        275                 280                 285             


Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Phe Tyr 
    290                 295                 300                 


Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr Cys 
305                 310                 315                 320 


Met Ala Val Cys Gly Ser Ala Met Ser Gln Ser Leu Leu Lys Thr Thr 
                325                 330                 335     


Gln Glu Pro Leu Ala Arg Asp Pro Val Lys Leu Pro Thr Thr Ala Ala 
            340                 345                 350         


Ser Thr Pro Asp Ala Val Asp Lys Tyr Leu Glu Thr Pro Gly Asp Glu 
        355                 360                 365             


Asn Glu His Ala His Phe Gln Lys Ala Lys Glu Arg Leu Glu Ala Lys 
    370                 375                 380                 


His Arg Glu Arg Met Ser Gln Val Met Arg Glu Trp Glu Glu Ala Glu 
385                 390                 395                 400 


Arg Gln Ala Lys Asn Leu Pro Lys Ala Asp Lys Lys Ala Val Ile Gln 
                405                 410                 415     


His Phe Gln Glu Lys Val Glu Ser Leu Glu Gln Glu Ala Ala Asn Glu 
            420                 425                 430         


Arg Gln Gln Leu Val Glu Thr His Met Ala Arg Val Glu Ala Met Leu 
        435                 440                 445             


Asn Asp Arg Arg Arg Leu Ala Leu Glu Asn Tyr Ile Thr Ala Leu Gln 
    450                 455                 460                 


Ala Val Pro Pro Arg Pro Arg His Val Phe Asn Met Leu Lys Lys Tyr 
465                 470                 475                 480 


Val Arg Ala Glu Gln Lys Asp Arg Gln His Thr Leu Lys His Phe Glu 
                485                 490                 495     


His Val Arg Met Val Asp Pro Lys Lys Ala Ala Gln Ile Arg Ser Gln 
            500                 505                 510         


Val Met Thr His Leu Arg Val Ile Tyr Glu Arg Met Asn Gln Ser Leu 
        515                 520                 525             


Ser Leu Leu Tyr Asn Val Pro Ala Val Ala Glu Glu Ile Gln Asp Glu 
    530                 535                 540                 


Val Asp Glu Leu Leu Gln Lys Glu Gln Asn Tyr Ser Asp Asp Val Leu 
545                 550                 555                 560 


Ala Asn Met Ile Ser Glu Pro Arg Ile Ser Tyr Gly Asn Asp Ala Leu 
                565                 570                 575     


Met Pro Ser Leu Thr Glu Thr Lys Thr Thr Val Glu Leu Leu Pro Val 
            580                 585                 590         


Asn Gly Glu Phe Ser Leu Asp Asp Leu Gln Pro Trp His Ser Phe Gly 
        595                 600                 605             


Ala Asp Ser Val Pro Ala Asn Thr Glu Asn Glu Val Glu Pro Val Asp 
    610                 615                 620                 


Ala Arg Pro Ala Ala Asp Arg Gly Leu Thr Thr Arg Pro Gly Ser Gly 
625                 630                 635                 640 


Leu Thr Asn Ile Lys Thr Glu Glu Ile Ser Glu Val Lys Met Asp Ala 
                645                 650                 655     


Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
            660                 665                 670 


<210>  4
<211>  654
<212>  PRT
<213>  Homo sapiens

<400>  4

Leu Glu Val Pro Thr Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro Gln 
1               5                   10                  15      


Ile Ala Met Phe Cys Gly Arg Leu Asn Met His Met Asn Val Gln Asn 
            20                  25                  30          


Gly Lys Trp Asp Ser Asp Pro Ser Gly Thr Lys Thr Cys Ile Asp Thr 
        35                  40                  45              


Lys Glu Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu Gln 
    50                  55                  60                  


Ile Thr Asn Val Val Glu Ala Asn Gln Pro Val Thr Ile Gln Asn Trp 
65                  70                  75                  80  


Cys Lys Arg Gly Arg Lys Gln Cys Lys Thr His Pro His Phe Val Ile 
                85                  90                  95      


Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu Val 
            100                 105                 110         


Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys Glu 
        115                 120                 125             


Thr His Leu His Trp His Thr Val Ala Lys Glu Thr Cys Ser Glu Lys 
    130                 135                 140                 


Ser Thr Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile Asp 
145                 150                 155                 160 


Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu Ser 
                165                 170                 175     


Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val Trp 
            180                 185                 190         


Trp Gly Gly Ala Asp Thr Asp Tyr Ala Asp Gly Ser Glu Asp Lys Val 
        195                 200                 205             


Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu Glu 
    210                 215                 220                 


Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu Glu 
225                 230                 235                 240 


Ala Glu Glu Pro Tyr Glu Glu Ala Thr Glu Arg Thr Thr Ser Ile Ala 
                245                 250                 255     


Thr Thr Thr Thr Thr Thr Thr Glu Ser Val Glu Glu Val Val Arg Glu 
            260                 265                 270         


Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Met Ile Ser 
        275                 280                 285             


Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Phe Tyr 
    290                 295                 300                 


Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr Cys 
305                 310                 315                 320 


Met Ala Val Cys Gly Ser Ala Met Ser Gln Ser Leu Leu Lys Thr Thr 
                325                 330                 335     


Gln Glu Pro Leu Ala Arg Asp Pro Val Lys Leu Pro Thr Thr Ala Ala 
            340                 345                 350         


Ser Thr Pro Asp Ala Val Asp Lys Tyr Leu Glu Thr Pro Gly Asp Glu 
        355                 360                 365             


Asn Glu His Ala His Phe Gln Lys Ala Lys Glu Arg Leu Glu Ala Lys 
    370                 375                 380                 


His Arg Glu Arg Met Ser Gln Val Met Arg Glu Trp Glu Glu Ala Glu 
385                 390                 395                 400 


Arg Gln Ala Lys Asn Leu Pro Lys Ala Asp Lys Lys Ala Val Ile Gln 
                405                 410                 415     


His Phe Gln Glu Lys Val Glu Ser Leu Glu Gln Glu Ala Ala Asn Glu 
            420                 425                 430         


Arg Gln Gln Leu Val Glu Thr His Met Ala Arg Val Glu Ala Met Leu 
        435                 440                 445             


Asn Asp Arg Arg Arg Leu Ala Leu Glu Asn Tyr Ile Thr Ala Leu Gln 
    450                 455                 460                 


Ala Val Pro Pro Arg Pro Arg His Val Phe Asn Met Leu Lys Lys Tyr 
465                 470                 475                 480 


Val Arg Ala Glu Gln Lys Asp Arg Gln His Thr Leu Lys His Phe Glu 
                485                 490                 495     


His Val Arg Met Val Asp Pro Lys Lys Ala Ala Gln Ile Arg Ser Gln 
            500                 505                 510         


Val Met Thr His Leu Arg Val Ile Tyr Glu Arg Met Asn Gln Ser Leu 
        515                 520                 525             


Ser Leu Leu Tyr Asn Val Pro Ala Val Ala Glu Glu Ile Gln Asp Glu 
    530                 535                 540                 


Val Asp Glu Leu Leu Gln Lys Glu Gln Asn Tyr Ser Asp Asp Val Leu 
545                 550                 555                 560 


Ala Asn Met Ile Ser Glu Pro Arg Ile Ser Tyr Gly Asn Asp Ala Leu 
                565                 570                 575     


Met Pro Ser Leu Thr Glu Thr Lys Thr Thr Val Glu Leu Leu Pro Val 
            580                 585                 590         


Asn Gly Glu Phe Ser Leu Asp Asp Leu Gln Pro Trp His Ser Phe Gly 
        595                 600                 605             


Ala Asp Ser Val Pro Ala Asn Thr Glu Asn Glu Val Glu Pro Val Asp 
    610                 615                 620                 


Ala Arg Pro Ala Ala Asp Arg Gly Leu Thr Thr Arg Pro Gly Ser Gly 
625                 630                 635                 640 


Leu Thr Asn Ile Lys Thr Glu Glu Ile Ser Glu Val Lys Met 
                645                 650                 


<210>  5
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  5

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr 
        35                  40                  45              


Leu Val Met Leu Lys Lys Lys Gln Tyr Thr Ser Ile His His Gly Val 
    50                  55                  60                  


Val Glu Val Asp Ala Ala Val Thr Pro Glu Glu Arg His Leu Ser Lys 
65                  70                  75                  80  


Met Gln Gln Asn Gly Tyr Glu Asn Pro Thr Tyr Lys Phe Phe Glu Gln 
                85                  90                  95      


Met Gln Asn 
            


<210>  6
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  6

Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
1               5                   10                  15      


Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr 
            20                  25                  30          


Leu Val Met Leu Lys Lys Lys Gln Tyr Thr Ser Ile His His Gly Val 
        35                  40                  45              


Val Glu Val Asp Ala Ala Val Thr Pro Glu Glu Arg His Leu Ser Lys 
    50                  55                  60                  


Met Gln Gln Asn Gly Tyr Glu Asn Pro Thr Tyr Lys Phe Phe Glu Gln 
65                  70                  75                  80  


Met Gln Asn 
            


<210>  7
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  7

Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
1               5                   10                  15      


Gly Leu Met Val Gly Gly Val Val Ile Ala 
            20                  25      


<210>  8
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  8

Ile Ala Thr Val Ile Val Ile Thr Leu Val Met Leu Lys Lys Lys Gln 
1               5                   10                  15      


Tyr Thr Ser Ile His His Gly Val Val Glu Val Asp Ala Ala Val Thr 
            20                  25                  30          


Pro Glu Glu Arg His Leu Ser Lys Met Gln Gln Asn Gly Tyr Glu Asn 
        35                  40                  45              


Pro Thr Tyr Lys Phe Phe Glu Gln Met Gln Asn 
    50                  55                  


