                         SEQUENCE LISTING

<110>  Rush University Medical Center
       Reiser, Jochen
       Hahm, Eunsi
       Cao, Yanxia
 
<120>  ICOSL FOR USE AS A RENAL THERAPEUTIC

<130>  14904-481

<150>  US 62/676,070
<151>  2018-05-24

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Leu Gly Ser Pro Gly Leu Leu Phe Leu Leu Phe Ser Ser Leu 
1               5                   10                  15      


Arg Ala Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp 
            20                  25                  30          


Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn 
        35                  40                  45              


Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr 
    50                  55                  60                  


Tyr His Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr 
65                  70                  75                  80  


Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe 
                85                  90                  95      


Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His 
            100                 105                 110         


Cys Leu Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val 
        115                 120                 125             


Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser 
    130                 135                 140                 


Ala Pro His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser 
145                 150                 155                 160 


Ile Asn Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp 
                165                 170                 175     


Asn Ser Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn 
            180                 185                 190         


Met Arg Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr 
        195                 200                 205             


Pro Ser Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln 
    210                 215                 220                 


Asn Leu Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp 
225                 230                 235                 240 


Lys Ile Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
                245                 250                 255     


Trp Ser Ile Leu Ala Val Leu Cys Leu Leu Val Val Val Ala Val Ala 
            260                 265                 270         


Ile Gly Trp Val Cys Arg Asp Arg Cys Leu Gln His Ser Tyr Ala Gly 
        275                 280                 285             


Ala Trp Ala Val Ser Pro Glu Thr Glu Leu Thr Gly His Val 
    290                 295                 300         


<210>  2
<211>  322
<212>  PRT
<213>  Mus musculus

<400>  2

Met Gln Leu Lys Cys Pro Cys Phe Val Ser Leu Gly Thr Arg Gln Pro 
1               5                   10                  15      


Val Trp Lys Lys Leu His Val Ser Ser Gly Phe Phe Ser Gly Leu Gly 
            20                  25                  30          


Leu Phe Leu Leu Leu Leu Ser Ser Leu Cys Ala Ala Ser Ala Glu Thr 
        35                  40                  45              


Glu Val Gly Ala Met Val Gly Ser Asn Val Val Leu Ser Cys Ile Asp 
    50                  55                  60                  


Pro His Arg Arg His Phe Asn Leu Ser Gly Leu Tyr Val Tyr Trp Gln 
65                  70                  75                  80  


Ile Glu Asn Pro Glu Val Ser Val Thr Tyr Tyr Leu Pro Tyr Lys Ser 
                85                  90                  95      


Pro Gly Ile Asn Val Asp Ser Ser Tyr Lys Asn Arg Gly His Leu Ser 
            100                 105                 110         


Leu Asp Ser Met Lys Gln Gly Asn Phe Ser Leu Tyr Leu Lys Asn Val 
        115                 120                 125             


Thr Pro Gln Asp Thr Gln Glu Phe Thr Cys Arg Val Phe Met Asn Thr 
    130                 135                 140                 


Ala Thr Glu Leu Val Lys Ile Leu Glu Glu Val Val Arg Leu Arg Val 
145                 150                 155                 160 


Ala Ala Asn Phe Ser Thr Pro Val Ile Ser Thr Ser Asp Ser Ser Asn 
                165                 170                 175     


Pro Gly Gln Glu Arg Thr Tyr Thr Cys Met Ser Lys Asn Gly Tyr Pro 
            180                 185                 190         


Glu Pro Asn Leu Tyr Trp Ile Asn Thr Thr Asp Asn Ser Leu Ile Asp 
        195                 200                 205             


Thr Ala Leu Gln Asn Asn Thr Val Tyr Leu Asn Lys Leu Gly Leu Tyr 
    210                 215                 220                 


Asp Val Ile Ser Thr Leu Arg Leu Pro Trp Thr Ser Arg Gly Asp Val 
225                 230                 235                 240 


Leu Cys Cys Val Glu Asn Val Ala Leu His Gln Asn Ile Thr Ser Ile 
                245                 250                 255     


Ser Gln Ala Glu Ser Phe Thr Gly Asn Asn Thr Lys Asn Pro Gln Glu 
            260                 265                 270         


Thr His Asn Asn Glu Leu Lys Val Leu Val Pro Val Leu Ala Val Leu 
        275                 280                 285             


Ala Ala Ala Ala Phe Val Ser Phe Ile Ile Tyr Arg Arg Thr Arg Pro 
    290                 295                 300                 


His Arg Ser Tyr Thr Gly Pro Lys Thr Val Gln Leu Glu Leu Thr Asp 
305                 310                 315                 320 


His Ala 
        


<210>  3
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL peptide

<400>  3

Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Cys 
1               5                   10                  15  


<210>  4
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ICOSL primer forward

<400>  4
atgcatcata tgcggctggg cagtcctgga ct                                     32


<210>  5
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ICOSL primer reverse

<400>  5
atggatctcg agttaaacgt ggccagtgag ctctg                                  35


<210>  6
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RGD mutation primer forward

<400>  6
tgcgtctgcc gtggacctct gctgcggctg ttctgtgctg cgttg                       45


<210>  7
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RGD mutation primer reverse

<400>  7
caacgcagca cagaacagcc gcagcagagg tccacggcag acgca                       45


