                         SEQUENCE LISTING

<110>  Ͼ˹﹤޹˾
 
<120>  ֲøͻ

<130>  1

<160>  118   

<170>  PatentIn version 3.5

<210>  1
<211>  410
<212>  PRT
<213>  Aspergillus niger

<400>  1

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Trp Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Gln Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Gly Leu Leu Ala Lys Lys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Ser Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Arg Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Tyr Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  2
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NOV9X

<400>  2

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Glu Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Trp Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Gly Leu Leu Pro Lys Cys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Glu Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Tyr Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Cys Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Asp Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  3
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-M1

<400>  3

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Phe Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Glu Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Trp Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Glu Leu Leu Pro Lys Cys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His His Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Val Ala Asn Val Thr Arg Ala Ile 
    130                 135                 140                 


Leu Glu Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Tyr Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Asp Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  4
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-A

<400>  4

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Cys Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Trp Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Gln Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Gly Leu Leu Ala Lys Lys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Ser Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Arg Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Cys Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Tyr Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  5
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-B

<400>  5

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Trp Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Cys Tyr Leu Gly His Tyr Gln Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Gly Leu Leu Ala Lys Lys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Cys Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Ser Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Arg Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Tyr Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  6
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-C

<400>  6

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Trp Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Cys Leu Gly His Tyr Gln Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Gly Leu Leu Ala Lys Lys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Ser Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Arg Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Tyr Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Cys Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  7
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-D

<400>  7

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Trp Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Cys Gln Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Gly Leu Leu Ala Lys Lys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Ser Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Arg Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Tyr Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Cys Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  8
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-E

<400>  8

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Trp Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Gln Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Gly Leu Leu Ala Lys Lys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Cys Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Ser Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Arg Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Tyr Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Cys Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  9
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-F

<400>  9

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Trp Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Gln Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Gly Leu Leu Ala Lys Lys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Cys 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Ser Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Arg Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Cys Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Tyr Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  10
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-G

<400>  10

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Trp Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Gln Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Gly Leu Leu Ala Lys Lys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Cys Thr Asp Ala Ile 
    130                 135                 140                 


Leu Ser Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Arg Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Tyr Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Cys Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  11
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-H

<400>  11

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Trp Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Gln Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Gly Leu Leu Ala Lys Lys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Ser Arg Ala Gly Gly Ser Ile Ala Asp Phe Cys Gly His Arg Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Cys Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Tyr Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  12
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-I

<400>  12

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Trp Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Gln Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Gly Leu Leu Ala Lys Lys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Ser Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Arg Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Cys Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Cys Leu Leu Ser Leu His Asn Ala Gln Phe Tyr Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  13
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-J

<400>  13

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Trp Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Gln Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Gly Leu Leu Ala Lys Lys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Ser Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Arg Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Cys Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Cys Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Tyr Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  14
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-K

<400>  14

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Trp Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Gln Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Gly Leu Leu Ala Lys Lys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Ser Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Arg Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Cys Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Cys Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Tyr Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  15
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-L

<400>  15

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Trp Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Gln Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Gly Leu Leu Ala Lys Lys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Ser Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Arg Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Tyr Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Cys Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Cys Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  16
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-M

<400>  16

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Trp Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Gln Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Gly Leu Leu Ala Lys Lys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Ser Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Arg Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Tyr Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Cys Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Cys Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  17
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-N

<400>  17

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Trp Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Gln Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Gly Leu Leu Ala Lys Lys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Ser Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Arg Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Tyr Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Cys Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Cys Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  18
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-O

<400>  18

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Trp Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Gln Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Gly Leu Leu Ala Lys Lys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Ser Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Arg Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Tyr Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Cys Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Cys Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  19
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-P

<400>  19

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Trp Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Gln Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Gly Leu Leu Ala Lys Lys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Ser Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Arg Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Tyr Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Cys Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Cys Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  20
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-M1-D

<400>  20

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Phe Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Glu Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Cys Trp Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Glu Leu Leu Pro Lys Cys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His His Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Val Ala Asn Val Thr Arg Ala Ile 
    130                 135                 140                 


Leu Glu Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Tyr Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Asp Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Cys Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  21
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-M1-O

<400>  21

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Phe Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Glu Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Trp Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Glu Leu Leu Pro Lys Cys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His His Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Val Ala Asn Val Thr Arg Ala Ile 
    130                 135                 140                 


Leu Glu Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Tyr Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Asp Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Cys Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Cys Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  22
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-M1-BO

<400>  22

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Phe Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Glu Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Cys Tyr Leu Gly His Tyr Trp Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Glu Leu Leu Pro Lys Cys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Cys Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His His Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Val Ala Asn Val Thr Arg Ala Ile 
    130                 135                 140                 


Leu Glu Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Tyr Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Asp Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Cys Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Cys Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  23
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-M1-CO

<400>  23

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Phe Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Glu Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Cys Leu Gly His Tyr Trp Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Glu Leu Leu Pro Lys Cys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His His Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Val Ala Asn Val Thr Arg Ala Ile 
    130                 135                 140                 


Leu Glu Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Tyr Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Asp Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Cys Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Cys Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Cys Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  24
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-M1-DO

<400>  24

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Phe Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Glu Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Cys Trp Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Glu Leu Leu Pro Lys Cys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His His Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Val Ala Asn Val Thr Arg Ala Ile 
    130                 135                 140                 


Leu Glu Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Tyr Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Asp Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Cys Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Cys Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Cys Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  25
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-M1-MO

<400>  25

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Phe Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Glu Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Trp Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Glu Leu Leu Pro Lys Cys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His His Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Val Ala Asn Val Thr Arg Ala Ile 
    130                 135                 140                 


Leu Glu Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Tyr Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Asp Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Cys Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Cys Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Cys Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Cys Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  26
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-M1-BDO

<400>  26

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Phe Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Glu Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Cys Tyr Leu Gly His Cys Trp Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Glu Leu Leu Pro Lys Cys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Cys Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His His Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Val Ala Asn Val Thr Arg Ala Ile 
    130                 135                 140                 


Leu Glu Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Tyr Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Asp Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Cys Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Cys Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Cys Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  27
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-M1-DMO

<400>  27

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Phe Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Glu Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Cys Trp Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Glu Leu Leu Pro Lys Cys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His His Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Val Ala Asn Val Thr Arg Ala Ile 
    130                 135                 140                 


Leu Glu Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Tyr Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Asp Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Cys Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Cys Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Cys Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Cys Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Cys Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  28
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPAan-A

<400>  28

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Cys Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Trp Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Gln Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Gly Leu Leu Ala Lys Lys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Ser Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Arg Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Cys Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Tyr Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  29
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPAan-B

<400>  29

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Trp Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Cys Tyr Leu Gly His Tyr Gln Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Gly Leu Leu Ala Lys Lys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Cys Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Ser Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Arg Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Tyr Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  30
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPAan-C

<400>  30

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Trp Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Cys Leu Gly His Tyr Gln Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Gly Leu Leu Ala Lys Lys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Ser Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Arg Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Tyr Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Cys Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  31
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPAan-D

<400>  31

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Trp Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Cys Gln Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Gly Leu Leu Ala Lys Lys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Ser Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Arg Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Tyr Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Cys Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  32
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPAan-E

<400>  32

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Trp Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Gln Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Gly Leu Leu Ala Lys Lys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Cys Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Ser Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Arg Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Tyr Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Cys Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  33
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPAan-F

<400>  33

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Trp Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Gln Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Gly Leu Leu Ala Lys Lys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Cys 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Ser Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Arg Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Cys Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Tyr Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  34
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPAan-I

<400>  34

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Trp Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Gln Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Gly Leu Leu Ala Lys Lys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Ser Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Arg Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Cys Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Cys Leu Leu Ser Leu His Asn Ala Gln Phe Tyr Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  35
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPAan-J

<400>  35

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Trp Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Gln Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Gly Leu Leu Ala Lys Lys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Ser Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Arg Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Cys Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Cys 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Tyr Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  36
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPAan-K

<400>  36

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Trp Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Gln Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Gly Leu Leu Ala Lys Lys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Ser Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Arg Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Cys Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Cys Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Tyr Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  37
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPAan-L

<400>  37

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Trp Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Gln Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Gly Leu Leu Ala Lys Lys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Ser Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Arg Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Tyr Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Cys Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Cys Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  38
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPAan-M

<400>  38

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Trp Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Gln Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Gly Leu Leu Ala Lys Lys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Ser Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Arg Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Tyr Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Cys Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Cys Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  39
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPAan-N

<400>  39

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Trp Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Gln Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Gly Leu Leu Ala Lys Lys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Ser Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Arg Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Tyr Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Cys Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Cys Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  40
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPAan-O

<400>  40

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Trp Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Gln Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Gly Leu Leu Ala Lys Lys Gly Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Ser Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Arg Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Pro Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Tyr Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro His Pro Pro Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Cys Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Cys Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  41
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-A

<400>  41
cagagtgagc ctgagttgaa actggaatcc gttgtcatcg tctctagaca tggtgttaga       60

gcaccaacca aggccaccca acttatgcaa gatgtcacct gtgacgcttg gccaacctgg      120

ccagtcaagc tgggttggtt gacacctaga ggtggtgagc tcattgctta cttgggtcac      180

taccaaagac agcgtcttgt tgccgacgga ttgttggcca agaagggttg tccacaatct      240

ggtcaagtag ctattattgc tgacgtcgac gaaagaaccc gtaagacagg tgaagccttc      300

gccgccggtc ttgctcctga ctgtgccatt accgttcaca cccaagctga cacttcttct      360

ccagatccat tgttcaaccc tttgaagact ggtgtttgcc aattggacaa cgctaacgtt      420

actgacgcta tcttgtccag agctggagga tccattgctg acttcaccgg tcacagacag      480

actgccttca gagagttgga aagagttctt aacttcccat gttcaaactt gtgcttgaag      540

cgtgagaagc aagacgaatc ctgttccttg actcaagcat taccatctga gttgaaggtc      600

tccgccgaca acgtctcttt gaccggtgct gtcagcttgg cttccatgtt gactgaaatc      660

tttcttctgc aacaagctca aggtatgcct gagccaggtt ggggtagaat caccgactct      720

caccaatgga acaccttgtt gtccttgcac aacgctcaat tctacttgct gcagagaact      780

ccagaggttg ctagatccag agccacccca ttgttggact tgatcaagac tgctttgact      840

cctcacccac ctcaaaagca agcctacggt gttaccttgc ccacttctgt cttgttcatt      900

gccggtcacg atactaactt ggcaaatctc ggcggtgctt tggagttgaa ctggactctt      960

cctggtcaac ctgataacac tccaccaggt ggtgagctcg ttttcgaaag atggcgtaga     1020

ctatctgata actctcaatg gattcaggtt tcgttggtct tccaaacttt gcagcagatg     1080

agagacaaga ctccactgtc tttgaacacg cctccaggag aagtcaaatt gaccttggct     1140

ggatgtgaag agagaaatgc tcagggtatg tgttccttgg ctggtttcac tcaaatcgtt     1200

aacgaagcta gaatcccagc ttgttccttg tag                                  1233


<210>  42
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-B

<400>  42
cagagtgagc ctgagttgaa actggaatcc gttgtcatcg tctctagaca tggtgttaga       60

gcaccaacca aggccaccca acttatgcaa gatgtcaccc cagacgcttg gccaacctgg      120

ccagtcaagc tgggttggtt gacacctaga ggtggtgagc tcatttgtta cttgggtcac      180

taccaaagac agcgtcttgt tgccgacgga ttgttggcca agaagggttg tccacaatct      240

ggtcaagtag ctattattgc tgacgtcgac gaaagaaccc gtaagacagg tgaagccttc      300

gccgcctgtc ttgctcctga ctgtgccatt accgttcaca cccaagctga cacttcttct      360

ccagatccat tgttcaaccc tttgaagact ggtgtttgcc aattggacaa cgctaacgtt      420

actgacgcta tcttgtccag agctggagga tccattgctg acttcaccgg tcacagacag      480

actgccttca gagagttgga aagagttctt aacttcccac aatcaaactt gtgcttgaag      540

cgtgagaagc aagacgaatc ctgttccttg actcaagcat taccatctga gttgaaggtc      600

tccgccgaca acgtctcttt gaccggtgct gtcagcttgg cttccatgtt gactgaaatc      660

tttcttctgc aacaagctca aggtatgcct gagccaggtt ggggtagaat caccgactct      720

caccaatgga acaccttgtt gtccttgcac aacgctcaat tctacttgct gcagagaact      780

ccagaggttg ctagatccag agccacccca ttgttggact tgatcaagac tgctttgact      840

cctcacccac ctcaaaagca agcctacggt gttaccttgc ccacttctgt cttgttcatt      900

gccggtcacg atactaactt ggcaaatctc ggcggtgctt tggagttgaa ctggactctt      960

cctggtcaac ctgataacac tccaccaggt ggtgagctcg ttttcgaaag atggcgtaga     1020

ctatctgata actctcaatg gattcaggtt tcgttggtct tccaaacttt gcagcagatg     1080

agagacaaga ctccactgtc tttgaacacg cctccaggag aagtcaaatt gaccttggct     1140

ggatgtgaag agagaaatgc tcagggtatg tgttccttgg ctggtttcac tcaaatcgtt     1200

aacgaagcta gaatcccagc ttgttccttg tag                                  1233


<210>  43
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-C

<400>  43
cagagtgagc ctgagttgaa actggaatcc gttgtcatcg tctctagaca tggtgttaga       60

gcaccaacca aggccaccca acttatgcaa gatgtcaccc cagacgcttg gccaacctgg      120

ccagtcaagc tgggttggtt gacacctaga ggtggtgagc tcattgcttg tttgggtcac      180

taccaaagac agcgtcttgt tgccgacgga ttgttggcca agaagggttg tccacaatct      240

ggtcaagtag ctattattgc tgacgtcgac gaaagaaccc gtaagacagg tgaagccttc      300

gccgccggtc ttgctcctga ctgtgccatt accgttcaca cccaagctga cacttcttct      360

ccagatccat tgttcaaccc tttgaagact ggtgtttgcc aattggacaa cgctaacgtt      420

actgacgcta tcttgtccag agctggagga tccattgctg acttcaccgg tcacagacag      480

actgccttca gagagttgga aagagttctt aacttcccac aatcaaactt gtgcttgaag      540

cgtgagaagc aagacgaatc ctgttccttg actcaagcat taccatctga gttgaaggtc      600

tccgccgaca acgtctcttt gaccggtgct gtcagcttgg cttccatgtt gactgaaatc      660

tttcttctgc aacaagctca aggtatgcct gagccaggtt ggggtagaat caccgactct      720

caccaatgga acaccttgtt gtccttgcac aacgctcaat tctacttgct gcagagaact      780

ccagaggttg ctagatccag agccacccca ttgttggact tgatcaagac tgctttgact      840

cctcacccac ctcaaaagca agcctacggt gttaccttgc ccacttctgt cttgttcatt      900

gccggtcacg atactaactt ggcaaatctc ggcggtgctt tggagttgaa ctggactctt      960

cctggtcaac ctgataacac tccaccaggt ggtgagctcg ttttcgaaag atggcgtaga     1020

ctatctgata actctcaatg gattcaggtt tcgttggtct tccaaacttt gcagcagatg     1080

agagacaaga ctccatgttc tttgaacacg cctccaggag aagtcaaatt gaccttggct     1140

ggatgtgaag agagaaatgc tcagggtatg tgttccttgg ctggtttcac tcaaatcgtt     1200

aacgaagcta gaatcccagc ttgttccttg tag                                  1233


<210>  44
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-D

<400>  44
cagagtgagc ctgagttgaa actggaatcc gttgtcatcg tctctagaca tggtgttaga       60

gcaccaacca aggccaccca acttatgcaa gatgtcaccc cagacgcttg gccaacctgg      120

ccagtcaagc tgggttggtt gacacctaga ggtggtgagc tcattgctta cttgggtcac      180

tgtcaaagac agcgtcttgt tgccgacgga ttgttggcca agaagggttg tccacaatct      240

ggtcaagtag ctattattgc tgacgtcgac gaaagaaccc gtaagacagg tgaagccttc      300

gccgccggtc ttgctcctga ctgtgccatt accgttcaca cccaagctga cacttcttct      360

ccagatccat tgttcaaccc tttgaagact ggtgtttgcc aattggacaa cgctaacgtt      420

actgacgcta tcttgtccag agctggagga tccattgctg acttcaccgg tcacagacag      480

actgccttca gagagttgga aagagttctt aacttcccac aatcaaactt gtgcttgaag      540

cgtgagaagc aagacgaatc ctgttccttg actcaagcat taccatctga gttgaaggtc      600

tccgccgaca acgtctcttt gaccggtgct gtcagcttgg cttccatgtt gactgaaatc      660

tttcttctgc aacaagctca aggtatgcct gagccaggtt ggggtagaat caccgactct      720

caccaatgga acaccttgtt gtccttgcac aacgctcaat tctacttgct gcagagaact      780

ccagaggttg ctagatccag agccacccca ttgttggact tgatcaagac tgctttgact      840

cctcacccac ctcaaaagca agcctacggt gttaccttgc ccacttctgt cttgttcatt      900

gccggtcacg atactaactt ggcaaatctc ggcggtgctt tggagttgaa ctggactctt      960

cctggtcaac ctgataacac tccaccaggt ggtgagctcg ttttcgaaag atggcgtaga     1020

ctatctgata actctcaatg gattcaggtt tcgttggtct tccaaacttt gcagcagatg     1080

agagacaaga ctccatgttc tttgaacacg cctccaggag aagtcaaatt gaccttggct     1140

ggatgtgaag agagaaatgc tcagggtatg tgttccttgg ctggtttcac tcaaatcgtt     1200

aacgaagcta gaatcccagc ttgttccttg tag                                  1233


<210>  45
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-E

<400>  45
cagagtgagc ctgagttgaa actggaatcc gttgtcatcg tctctagaca tggtgttaga       60

gcaccaacca aggccaccca acttatgcaa gatgtcaccc cagacgcttg gccaacctgg      120

ccagtcaagc tgggttggtt gacacctaga ggtggtgagc tcattgctta cttgggtcac      180

taccaaagac agcgtcttgt tgccgacgga ttgttggcca agaagggttg tccacaatct      240

ggttgtgtag ctattattgc tgacgtcgac gaaagaaccc gtaagacagg tgaagccttc      300

gccgccggtc ttgctcctga ctgtgccatt accgttcaca cccaagctga cacttcttct      360

ccagatccat tgttcaaccc tttgaagact ggtgtttgcc aattggacaa cgctaacgtt      420

actgacgcta tcttgtccag agctggagga tccattgctg acttcaccgg tcacagacag      480

actgccttca gagagttgga aagagttctt aacttcccac aatcaaactt gtgcttgaag      540

cgtgagaagc aagacgaatc ctgttccttg actcaagcat taccatctga gttgaaggtc      600

tccgccgaca acgtctcttt gaccggtgct gtcagcttgg cttccatgtt gactgaaatc      660

tttcttctgc aacaagctca aggtatgcct gagccaggtt ggggtagaat caccgactct      720

caccaatgga acaccttgtt gtccttgcac aacgctcaat tctacttgct gcagagaact      780

ccagaggttg ctagatccag agccacccca ttgttggact tgatcaagac tgctttgact      840

cctcacccac ctcaaaagca agcctacggt gttaccttgc ccacttgtgt cttgttcatt      900

gccggtcacg atactaactt ggcaaatctc ggcggtgctt tggagttgaa ctggactctt      960

cctggtcaac ctgataacac tccaccaggt ggtgagctcg ttttcgaaag atggcgtaga     1020

ctatctgata actctcaatg gattcaggtt tcgttggtct tccaaacttt gcagcagatg     1080

agagacaaga ctccactgtc tttgaacacg cctccaggag aagtcaaatt gaccttggct     1140

ggatgtgaag agagaaatgc tcagggtatg tgttccttgg ctggtttcac tcaaatcgtt     1200

aacgaagcta gaatcccagc ttgttccttg tag                                  1233


<210>  46
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-F

<400>  46
cagagtgagc ctgagttgaa actggaatcc gttgtcatcg tctctagaca tggtgttaga       60

gcaccaacca aggccaccca acttatgcaa gatgtcaccc cagacgcttg gccaacctgg      120

ccagtcaagc tgggttggtt gacacctaga ggtggtgagc tcattgctta cttgggtcac      180

taccaaagac agcgtcttgt tgccgacgga ttgttggcca agaagggttg tccacaatct      240

ggtcaagtag ctattattgc tgacgtcgac gaaagaaccc gtaagacagg tgaagccttc      300

gccgccggtc ttgctcctga ctgtgccatt accgttcaca cccaagctga cacttcttct      360

ccagatccat tgttcaaccc ttgtaagact ggtgtttgcc aattggacaa cgctaacgtt      420

actgacgcta tcttgtccag agctggagga tccattgctg acttcaccgg tcacagacag      480

actgccttca gagagttgga aagagttctt aacttcccac aatcaaactt gtgcttgaag      540

cgtgagaagc aagacgaatc ctgttccttg actcaagcat taccatctga gttgaaggtc      600

tccgcctgta acgtctcttt gaccggtgct gtcagcttgg cttccatgtt gactgaaatc      660

tttcttctgc aacaagctca aggtatgcct gagccaggtt ggggtagaat caccgactct      720

caccaatgga acaccttgtt gtccttgcac aacgctcaat tctacttgct gcagagaact      780

ccagaggttg ctagatccag agccacccca ttgttggact tgatcaagac tgctttgact      840

cctcacccac ctcaaaagca agcctacggt gttaccttgc ccacttctgt cttgttcatt      900

gccggtcacg atactaactt ggcaaatctc ggcggtgctt tggagttgaa ctggactctt      960

cctggtcaac ctgataacac tccaccaggt ggtgagctcg ttttcgaaag atggcgtaga     1020

ctatctgata actctcaatg gattcaggtt tcgttggtct tccaaacttt gcagcagatg     1080

agagacaaga ctccactgtc tttgaacacg cctccaggag aagtcaaatt gaccttggct     1140

ggatgtgaag agagaaatgc tcagggtatg tgttccttgg ctggtttcac tcaaatcgtt     1200

aacgaagcta gaatcccagc ttgttccttg tag                                  1233


<210>  47
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-G

<400>  47
cagagtgagc ctgagttgaa actggaatcc gttgtcatcg tctctagaca tggtgttaga       60

gcaccaacca aggccaccca acttatgcaa gatgtcaccc cagacgcttg gccaacctgg      120

ccagtcaagc tgggttggtt gacacctaga ggtggtgagc tcattgctta cttgggtcac      180

taccaaagac agcgtcttgt tgccgacgga ttgttggcca agaagggttg tccacaatct      240

ggtcaagtag ctattattgc tgacgtcgac gaaagaaccc gtaagacagg tgaagccttc      300

gccgccggtc ttgctcctga ctgtgccatt accgttcaca cccaagctga cacttcttct      360

ccagatccat tgttcaaccc tttgaagact ggtgtttgcc aattggacaa cgctaactgt      420

actgacgcta tcttgtccag agctggagga tccattgctg acttcaccgg tcacagacag      480

actgccttca gagagttgga aagagttctt aacttcccac aatcaaactt gtgcttgaag      540

cgtgagaagc aagacgaatc ctgttccttg actcaagcat taccatctga gttgaaggtc      600

tccgccgaca acgtctcttt gaccggtgct gtcagcttgg cttccatgtt gactgaaatc      660

tttcttctgc aacaagctca aggtatgcct gagccaggtt ggggtagaat caccgactct      720

caccaatgga acaccttgtt gtccttgcac aacgctcaat tctacttgct gcagagaact      780

ccatgtgttg ctagatccag agccacccca ttgttggact tgatcaagac tgctttgact      840

cctcacccac ctcaaaagca agcctacggt gttaccttgc ccacttctgt cttgttcatt      900

gccggtcacg atactaactt ggcaaatctc ggcggtgctt tggagttgaa ctggactctt      960

cctggtcaac ctgataacac tccaccaggt ggtgagctcg ttttcgaaag atggcgtaga     1020

ctatctgata actctcaatg gattcaggtt tcgttggtct tccaaacttt gcagcagatg     1080

agagacaaga ctccactgtc tttgaacacg cctccaggag aagtcaaatt gaccttggct     1140

ggatgtgaag agagaaatgc tcagggtatg tgttccttgg ctggtttcac tcaaatcgtt     1200

aacgaagcta gaatcccagc ttgttccttg tag                                  1233


<210>  48
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-H

<400>  48
cagagtgagc ctgagttgaa actggaatcc gttgtcatcg tctctagaca tggtgttaga       60

gcaccaacca aggccaccca acttatgcaa gatgtcaccc cagacgcttg gccaacctgg      120

ccagtcaagc tgggttggtt gacacctaga ggtggtgagc tcattgctta cttgggtcac      180

taccaaagac agcgtcttgt tgccgacgga ttgttggcca agaagggttg tccacaatct      240

ggtcaagtag ctattattgc tgacgtcgac gaaagaaccc gtaagacagg tgaagccttc      300

gccgccggtc ttgctcctga ctgtgccatt accgttcaca cccaagctga cacttcttct      360

ccagatccat tgttcaaccc tttgaagact ggtgtttgcc aattggacaa cgctaacgtt      420

actgacgcta tcttgtccag agctggagga tccattgctg acttctgtgg tcacagacag      480

actgccttca gagagttgga aagagttctt aacttcccac aatcaaactt gtgcttgaag      540

cgtgagaagc aagacgaatc ctgttccttg tgtcaagcat taccatctga gttgaaggtc      600

tccgccgaca acgtctcttt gaccggtgct gtcagcttgg cttccatgtt gactgaaatc      660

tttcttctgc aacaagctca aggtatgcct gagccaggtt ggggtagaat caccgactct      720

caccaatgga acaccttgtt gtccttgcac aacgctcaat tctacttgct gcagagaact      780

ccagaggttg ctagatccag agccacccca ttgttggact tgatcaagac tgctttgact      840

cctcacccac ctcaaaagca agcctacggt gttaccttgc ccacttctgt cttgttcatt      900

gccggtcacg atactaactt ggcaaatctc ggcggtgctt tggagttgaa ctggactctt      960

cctggtcaac ctgataacac tccaccaggt ggtgagctcg ttttcgaaag atggcgtaga     1020

ctatctgata actctcaatg gattcaggtt tcgttggtct tccaaacttt gcagcagatg     1080

agagacaaga ctccactgtc tttgaacacg cctccaggag aagtcaaatt gaccttggct     1140

ggatgtgaag agagaaatgc tcagggtatg tgttccttgg ctggtttcac tcaaatcgtt     1200

aacgaagcta gaatcccagc ttgttccttg tag                                  1233


<210>  49
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-I

<400>  49
cagagtgagc ctgagttgaa actggaatcc gttgtcatcg tctctagaca tggtgttaga       60

gcaccaacca aggccaccca acttatgcaa gatgtcaccc cagacgcttg gccaacctgg      120

ccagtcaagc tgggttggtt gacacctaga ggtggtgagc tcattgctta cttgggtcac      180

taccaaagac agcgtcttgt tgccgacgga ttgttggcca agaagggttg tccacaatct      240

ggtcaagtag ctattattgc tgacgtcgac gaaagaaccc gtaagacagg tgaagccttc      300

gccgccggtc ttgctcctga ctgtgccatt accgttcaca cccaagctga cacttcttct      360

ccagatccat tgttcaaccc tttgaagact ggtgtttgcc aattggacaa cgctaacgtt      420

actgacgcta tcttgtccag agctggagga tccattgctg acttcaccgg tcacagacag      480

actgccttca gatgtttgga aagagttctt aacttcccac aatcaaactt gtgcttgaag      540

cgtgagaagc aagacgaatc ctgttccttg actcaagcat taccatctga gttgaaggtc      600

tccgccgaca acgtctcttt gaccggtgct gtcagcttgg cttccatgtt gactgaaatc      660

tttcttctgc aacaagctca aggtatgcct gagccaggtt ggggtagaat caccgactct      720

caccaatgga actgtttgtt gtccttgcac aacgctcaat tctacttgct gcagagaact      780

ccagaggttg ctagatccag agccacccca ttgttggact tgatcaagac tgctttgact      840

cctcacccac ctcaaaagca agcctacggt gttaccttgc ccacttctgt cttgttcatt      900

gccggtcacg atactaactt ggcaaatctc ggcggtgctt tggagttgaa ctggactctt      960

cctggtcaac ctgataacac tccaccaggt ggtgagctcg ttttcgaaag atggcgtaga     1020

ctatctgata actctcaatg gattcaggtt tcgttggtct tccaaacttt gcagcagatg     1080

agagacaaga ctccactgtc tttgaacacg cctccaggag aagtcaaatt gaccttggct     1140

ggatgtgaag agagaaatgc tcagggtatg tgttccttgg ctggtttcac tcaaatcgtt     1200

aacgaagcta gaatcccagc ttgttccttg tag                                  1233


<210>  50
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-J

<400>  50
cagagtgagc ctgagttgaa actggaatcc gttgtcatcg tctctagaca tggtgttaga       60

gcaccaacca aggccaccca acttatgcaa gatgtcaccc cagacgcttg gccaacctgg      120

ccagtcaagc tgggttggtt gacacctaga ggtggtgagc tcattgctta cttgggtcac      180

taccaaagac agcgtcttgt tgccgacgga ttgttggcca agaagggttg tccacaatct      240

ggtcaagtag ctattattgc tgacgtcgac gaaagaaccc gtaagacagg tgaagccttc      300

gccgccggtc ttgctcctga ctgtgccatt accgttcaca cccaagctga cacttcttct      360

ccagatccat tgttcaaccc tttgaagact ggtgtttgcc aattggacaa cgctaacgtt      420

actgacgcta tcttgtccag agctggagga tccattgctg acttcaccgg tcacagacag      480

actgccttca gagagttgga aagagttctt aacttcccac aatcaaactt gtgcttgaag      540

cgtgagaagc aagacgaatc ctgttccttg tgtcaagcat taccatctga gttgaaggtc      600

tccgccgaca acgtctcttt gaccggttgt gtcagcttgg cttccatgtt gactgaaatc      660

tttcttctgc aacaagctca aggtatgcct gagccaggtt ggggtagaat caccgactct      720

caccaatgga acaccttgtt gtccttgcac aacgctcaat tctacttgct gcagagaact      780

ccagaggttg ctagatccag agccacccca ttgttggact tgatcaagac tgctttgact      840

cctcacccac ctcaaaagca agcctacggt gttaccttgc ccacttctgt cttgttcatt      900

gccggtcacg atactaactt ggcaaatctc ggcggtgctt tggagttgaa ctggactctt      960

cctggtcaac ctgataacac tccaccaggt ggtgagctcg ttttcgaaag atggcgtaga     1020

ctatctgata actctcaatg gattcaggtt tcgttggtct tccaaacttt gcagcagatg     1080

agagacaaga ctccactgtc tttgaacacg cctccaggag aagtcaaatt gaccttggct     1140

ggatgtgaag agagaaatgc tcagggtatg tgttccttgg ctggtttcac tcaaatcgtt     1200

aacgaagcta gaatcccagc ttgttccttg tag                                  1233


<210>  51
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-K

<400>  51
cagagtgagc ctgagttgaa actggaatcc gttgtcatcg tctctagaca tggtgttaga       60

gcaccaacca aggccaccca acttatgcaa gatgtcaccc cagacgcttg gccaacctgg      120

ccagtcaagc tgggttggtt gacacctaga ggtggtgagc tcattgctta cttgggtcac      180

taccaaagac agcgtcttgt tgccgacgga ttgttggcca agaagggttg tccacaatct      240

ggtcaagtag ctattattgc tgacgtcgac gaaagaaccc gtaagacagg tgaagccttc      300

gccgccggtc ttgctcctga ctgtgccatt accgttcaca cccaagctga cacttcttct      360

ccagatccat tgttcaaccc tttgaagact ggtgtttgcc aattggacaa cgctaacgtt      420

actgacgcta tcttgtccag agctggagga tccattgctg acttcaccgg tcacagacag      480

actgccttca gagagttgga aagagttctt aacttcccac aatcaaactt gtgcttgaag      540

cgtgagaagc aagacgaatc ctgttccttg actcaagcat taccatgtga gttgaaggtc      600

tccgccgaca acgtctcttt gaccggtgct tgtagcttgg cttccatgtt gactgaaatc      660

tttcttctgc aacaagctca aggtatgcct gagccaggtt ggggtagaat caccgactct      720

caccaatgga acaccttgtt gtccttgcac aacgctcaat tctacttgct gcagagaact      780

ccagaggttg ctagatccag agccacccca ttgttggact tgatcaagac tgctttgact      840

cctcacccac ctcaaaagca agcctacggt gttaccttgc ccacttctgt cttgttcatt      900

gccggtcacg atactaactt ggcaaatctc ggcggtgctt tggagttgaa ctggactctt      960

cctggtcaac ctgataacac tccaccaggt ggtgagctcg ttttcgaaag atggcgtaga     1020

ctatctgata actctcaatg gattcaggtt tcgttggtct tccaaacttt gcagcagatg     1080

agagacaaga ctccactgtc tttgaacacg cctccaggag aagtcaaatt gaccttggct     1140

ggatgtgaag agagaaatgc tcagggtatg tgttccttgg ctggtttcac tcaaatcgtt     1200

aacgaagcta gaatcccagc ttgttccttg tag                                  1233


<210>  52
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-L

<400>  52
cagagtgagc ctgagttgaa actggaatcc gttgtcatcg tctctagaca tggtgttaga       60

gcaccaacca aggccaccca acttatgcaa gatgtcaccc cagacgcttg gccaacctgg      120

ccagtcaagc tgggttggtt gacacctaga ggtggtgagc tcattgctta cttgggtcac      180

taccaaagac agcgtcttgt tgccgacgga ttgttggcca agaagggttg tccacaatct      240

ggtcaagtag ctattattgc tgacgtcgac gaaagaaccc gtaagacagg tgaagccttc      300

gccgccggtc ttgctcctga ctgtgccatt accgttcaca cccaagctga cacttcttct      360

ccagatccat tgttcaaccc tttgaagact ggtgtttgcc aattggacaa cgctaacgtt      420

actgacgcta tcttgtccag agctggagga tccattgctg acttcaccgg tcacagacag      480

actgccttca gagagttgga aagagttctt aacttcccac aatcaaactt gtgcttgaag      540

cgtgagaagc aagacgaatc ctgttccttg actcaagcat taccatctga gttgaaggtc      600

tccgccgaca acgtctcttt gaccggtgct gtcagcttgg cttccatgtt gactgaaatc      660

tttcttctgc aacaagctca aggtatgcct gagccaggtt ggggtagaat caccgactct      720

caccaatgga acaccttgtt gtccttgcac aacgctcaat tctacttgct gcagagaact      780

ccagaggttt gtagatccag agccacccca ttgttggact tgatcaagac tgctttgact      840

cctcacccac ctcaaaagca agcctacggt gttaccttgc ccacttctgt cttgttcatt      900

gccggtcacg atactaactt ggcaaatctc ggctgtgctt tggagttgaa ctggactctt      960

cctggtcaac ctgataacac tccaccaggt ggtgagctcg ttttcgaaag atggcgtaga     1020

ctatctgata actctcaatg gattcaggtt tcgttggtct tccaaacttt gcagcagatg     1080

agagacaaga ctccactgtc tttgaacacg cctccaggag aagtcaaatt gaccttggct     1140

ggatgtgaag agagaaatgc tcagggtatg tgttccttgg ctggtttcac tcaaatcgtt     1200

aacgaagcta gaatcccagc ttgttccttg tag                                  1233


<210>  53
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-M

<400>  53
cagagtgagc ctgagttgaa actggaatcc gttgtcatcg tctctagaca tggtgttaga       60

gcaccaacca aggccaccca acttatgcaa gatgtcaccc cagacgcttg gccaacctgg      120

ccagtcaagc tgggttggtt gacacctaga ggtggtgagc tcattgctta cttgggtcac      180

taccaaagac agcgtcttgt tgccgacgga ttgttggcca agaagggttg tccacaatct      240

ggtcaagtag ctattattgc tgacgtcgac gaaagaaccc gtaagacagg tgaagccttc      300

gccgccggtc ttgctcctga ctgtgccatt accgttcaca cccaagctga cacttcttct      360

ccagatccat tgttcaaccc tttgaagact ggtgtttgcc aattggacaa cgctaacgtt      420

actgacgcta tcttgtccag agctggagga tccattgctg acttcaccgg tcacagacag      480

actgccttca gagagttgga aagagttctt aacttcccac aatcaaactt gtgcttgaag      540

cgtgagaagc aagacgaatc ctgttccttg actcaagcat taccatctga gttgaaggtc      600

tccgccgaca acgtctcttt gaccggtgct gtcagcttgg cttccatgtt gactgaaatc      660

tttcttctgc aacaagctca aggtatgcct gagccaggtt ggggtagaat caccgactct      720

caccaatgga acaccttgtt gtccttgcac aacgctcaat tctacttgct gcagagaact      780

ccagaggttg ctagatccag agccacccca ttgttggact tgatcaagac tgctttgact      840

cctcacccac ctcaaaagca agcctacggt gttaccttgc ccacttctgt cttgttcatt      900

gccggtcacg atactaactt ggcaaatctc ggcggtgctt tgtgtttgaa ctggactctt      960

cctggtcaac ctgataacac tccaccaggt ggtgagctcg ttttcgaaag atggcgtaga     1020

ctatctgata actctcaatg gattcaggtt tcgttggtct tccaaacttt gcagcagatg     1080

agagacaaga ctccactgtc tttgaacacg cctccaggag aagtcaaatt gaccttgtgt     1140

ggatgtgaag agagaaatgc tcagggtatg tgttccttgg ctggtttcac tcaaatcgtt     1200

aacgaagcta gaatcccagc ttgttccttg tag                                  1233


<210>  54
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-N

<400>  54
cagagtgagc ctgagttgaa actggaatcc gttgtcatcg tctctagaca tggtgttaga       60

gcaccaacca aggccaccca acttatgcaa gatgtcaccc cagacgcttg gccaacctgg      120

ccagtcaagc tgggttggtt gacacctaga ggtggtgagc tcattgctta cttgggtcac      180

taccaaagac agcgtcttgt tgccgacgga ttgttggcca agaagggttg tccacaatct      240

ggtcaagtag ctattattgc tgacgtcgac gaaagaaccc gtaagacagg tgaagccttc      300

gccgccggtc ttgctcctga ctgtgccatt accgttcaca cccaagctga cacttcttct      360

ccagatccat tgttcaaccc tttgaagact ggtgtttgcc aattggacaa cgctaacgtt      420

actgacgcta tcttgtccag agctggagga tccattgctg acttcaccgg tcacagacag      480

actgccttca gagagttgga aagagttctt aacttcccac aatcaaactt gtgcttgaag      540

cgtgagaagc aagacgaatc ctgttccttg actcaagcat taccatctga gttgaaggtc      600

tccgccgaca acgtctcttt gaccggtgct gtcagcttgg cttccatgtt gactgaaatc      660

tttcttctgc aacaagctca aggtatgcct gagccaggtt ggggtagaat caccgactct      720

caccaatgga acaccttgtt gtccttgcac aacgctcaat tctacttgct gcagagaact      780

ccagaggttg ctagatccag agccacccca ttgttggact tgatcaagac tgctttgact      840

cctcacccac ctcaaaagca agcctacggt gttaccttgc ccacttctgt cttgttcatt      900

gccggtcacg atactaactt ggcaaatctc ggcggtgctt tggagttgaa ctggactctt      960

ccttgtcaac ctgataacac tccaccaggt ggtgagctcg ttttcgaaag atggcgtaga     1020

ctatctgata actctcaatg gattcaggtt tcgttggtct tccaatgttt gcagcagatg     1080

agagacaaga ctccactgtc tttgaacacg cctccaggag aagtcaaatt gaccttggct     1140

ggatgtgaag agagaaatgc tcagggtatg tgttccttgg ctggtttcac tcaaatcgtt     1200

aacgaagcta gaatcccagc ttgttccttg tag                                  1233


<210>  55
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-O

<400>  55
cagagtgagc ctgagttgaa actggaatcc gttgtcatcg tctctagaca tggtgttaga       60

gcaccaacca aggccaccca acttatgcaa gatgtcaccc cagacgcttg gccaacctgg      120

ccagtcaagc tgggttggtt gacacctaga ggtggtgagc tcattgctta cttgggtcac      180

taccaaagac agcgtcttgt tgccgacgga ttgttggcca agaagggttg tccacaatct      240

ggtcaagtag ctattattgc tgacgtcgac gaaagaaccc gtaagacagg tgaagccttc      300

gccgccggtc ttgctcctga ctgtgccatt accgttcaca cccaagctga cacttcttct      360

ccagatccat tgttcaaccc tttgaagact ggtgtttgcc aattggacaa cgctaacgtt      420

actgacgcta tcttgtccag agctggagga tccattgctg acttcaccgg tcacagacag      480

actgccttca gagagttgga aagagttctt aacttcccac aatcaaactt gtgcttgaag      540

cgtgagaagc aagacgaatc ctgttccttg actcaagcat taccatctga gttgaaggtc      600

tccgccgaca acgtctcttt gaccggtgct gtcagcttgg cttccatgtt gactgaaatc      660

tttcttctgc aacaagctca aggtatgcct gagccaggtt ggggtagaat caccgactct      720

caccaatgga acaccttgtt gtccttgcac aacgctcaat tctacttgct gcagagaact      780

ccagaggttg ctagatccag agccacccca ttgttggact tgatcaagac tgctttgact      840

cctcacccac ctcaaaagca agcctacggt gttaccttgc ccacttctgt cttgttcatt      900

gccggtcacg atactaactt ggcaaatctc ggcggtgctt tggagttgaa ctggactctt      960

cctggtcaac ctgataacac tccaccaggt ggtgagctcg ttttcgaaag atggcgtaga     1020

ctatctgata actcttgttg gattcaggtt tcgttggtct tccaaacttt gcagcagatg     1080

agagacaaga ctccactgtc tttgaacacg cctccaggag aagtcaaatt gaccttggct     1140

ggatgtgaag agagaaatgc tcagggtatg tgttcctgtg ctggtttcac tcaaatcgtt     1200

aacgaagcta gaatcccagc ttgttccttg tag                                  1233


<210>  56
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-P

<400>  56
cagagtgagc ctgagttgaa actggaatcc gttgtcatcg tctctagaca tggtgttaga       60

gcaccaacca aggccaccca acttatgcaa gatgtcaccc cagacgcttg gccaacctgg      120

ccagtcaagc tgggttggtt gacacctaga ggtggtgagc tcattgctta cttgggtcac      180

taccaaagac agcgtcttgt tgccgacgga ttgttggcca agaagggttg tccacaatct      240

ggtcaagtag ctattattgc tgacgtcgac gaaagaaccc gtaagacagg tgaagccttc      300

gccgccggtc ttgctcctga ctgtgccatt accgttcaca cccaagctga cacttcttct      360

ccagatccat tgttcaaccc tttgaagact ggtgtttgcc aattggacaa cgctaacgtt      420

actgacgcta tcttgtccag agctggagga tccattgctg acttcaccgg tcacagacag      480

actgccttca gagagttgga aagagttctt aacttcccac aatcaaactt gtgcttgaag      540

cgtgagaagc aagacgaatc ctgttccttg actcaagcat taccatctga gttgaaggtc      600

tccgccgaca acgtctcttt gaccggtgct gtcagcttgg cttccatgtt gactgaaatc      660

tttcttctgc aacaagctca aggtatgcct gagccaggtt ggggtagaat caccgactct      720

caccaatgga acaccttgtt gtccttgcac aacgctcaat tctacttgct gcagagaact      780

ccagaggttg ctagatccag agccacccca ttgttggact tgatcaagac tgctttgact      840

cctcacccac ctcaaaagca agcctacggt gttaccttgc ccacttctgt cttgttcatt      900

gccggtcacg atactaactt ggcaaatctc ggcggtgctt tggagttgaa ctggactctt      960

cctggtcaac ctgataacac tccaccaggt ggtgagctcg ttttcgaaag atggcgtaga     1020

ctatctgata actctcaatg gatttgtgtt tcgttggtct tccaaacttt gcagcagatg     1080

agagacaaga ctccactgtc tttgaacacg cctccaggag aagtcaaatt gaccttggct     1140

ggatgtgaag agagaaatgc tcagggttgt tgttccttgg ctggtttcac tcaaatcgtt     1200

aacgaagcta gaatcccagc ttgttccttg tag                                  1233


<210>  57
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-M1-D

<400>  57
cagagtgagc ctgagttgaa actggaatcc gttgtcatcg tctctagaca tggtgttaga       60

gcaccaacca agttcaccca acttatgcaa gatgtcaccc cagacgcttg gccaacctgg      120

ccagtcaagc tgggtgaatt gacacctaga ggtggtgagc tcattgctta cttgggtcac      180

tgttggagac agcgtcttgt tgccgacgaa ttgttgccta agtgtggttg tccacaatct      240

ggtcaagtag ctattattgc tgacgtcgac gaaagaaccc gtaagacagg tgaagccttc      300

gccgccggtc ttgctcctga ctgtgccatt accgttcacc atcaagctga cacttcttct      360

ccagatccat tgttcaaccc tttgaagact ggtgtttgcc aattggacgt tgctaacgtt      420

actagagcta tcttggaaag agctggagga tctattgctg acttcaccgg tcactaccag      480

actgccttca gagagttgga aagagttctt aacttcccac aatccaactt gtgccttaag      540

cgtgagaagc aagacgaatc ctgttccttg actcaagcat taccatctga gttgaaggtc      600

tccgccgaca acgtctcttt gaccggtgct gtcagcttgg cttccatgtt gactgaaatc      660

tttcttctgc aacaagctca aggtatgcct gagccaggtt ggggtagaat caccgactct      720

caccaatgga acaccttgtt gtccttgcac aacgctcaat tcgatttgct gcagagaact      780

ccagaggttg ctagatccag agccacccca ttgttggact tgatcaagac tgctttgact      840

cctcacccac ctcaaaagca agcctacggt gttaccttgc ccacttctgt cttgttcatt      900

gccggtcacg atactaactt ggcaaatctc ggcggtgctt tggagttgaa ctggactctt      960

cctggtcaac ctgataacac tccaccaggt ggtgagctcg ttttcgaaag atggcgtaga     1020

ctatctgata actctcaatg gattcaggtt tcgttggtct tccaaacttt gcagcagatg     1080

agagacaaga ctccatgttc tttgaacacg cctccaggag aagtcaaatt gaccttggct     1140

ggatgtgaag agagaaatgc tcagggtatg tgttccttgg ctggtttcac tcaaatcgtt     1200

aacgaagcta gaatcccagc ttgttccttg tag                                  1233


<210>  58
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-M1-O

<400>  58
cagagtgagc ctgagttgaa actggaatcc gttgtcatcg tctctagaca tggtgttaga       60

gcaccaacca agttcaccca acttatgcaa gatgtcaccc cagacgcttg gccaacctgg      120

ccagtcaagc tgggtgaatt gacacctaga ggtggtgagc tcattgctta cttgggtcac      180

tactggagac agcgtcttgt tgccgacgaa ttgttgccta agtgtggttg tccacaatct      240

ggtcaagtag ctattattgc tgacgtcgac gaaagaaccc gtaagacagg tgaagccttc      300

gccgccggtc ttgctcctga ctgtgccatt accgttcacc atcaagctga cacttcttct      360

ccagatccat tgttcaaccc tttgaagact ggtgtttgcc aattggacgt tgctaacgtt      420

actagagcta tcttggaaag agctggagga tctattgctg acttcaccgg tcactaccag      480

actgccttca gagagttgga aagagttctt aacttcccac aatccaactt gtgccttaag      540

cgtgagaagc aagacgaatc ctgttccttg actcaagcat taccatctga gttgaaggtc      600

tccgccgaca acgtctcttt gaccggtgct gtcagcttgg cttccatgtt gactgaaatc      660

tttcttctgc aacaagctca aggtatgcct gagccaggtt ggggtagaat caccgactct      720

caccaatgga acaccttgtt gtccttgcac aacgctcaat tcgatttgct gcagagaact      780

ccagaggttg ctagatccag agccacccca ttgttggact tgatcaagac tgctttgact      840

cctcacccac ctcaaaagca agcctacggt gttaccttgc ccacttctgt cttgttcatt      900

gccggtcacg atactaactt ggcaaatctc ggcggtgctt tggagttgaa ctggactctt      960

cctggtcaac ctgataacac tccaccaggt ggtgagctcg ttttcgaaag atggcgtaga     1020

ctatctgata actcttgttg gattcaggtt tcgttggtct tccaaacttt gcagcagatg     1080

agagacaaga ctccactgtc tttgaacacg cctccaggag aagtcaaatt gaccttggct     1140

ggatgtgaag agagaaatgc tcagggtatg tgttcctgtg ctggtttcac tcaaatcgtt     1200

aacgaagcta gaatcccagc ttgttccttg tag                                  1233


<210>  59
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-M1-BO

<400>  59
cagagtgagc ctgagttgaa actggaatcc gttgtcatcg tctctagaca tggtgttaga       60

gcaccaacca agttcaccca acttatgcaa gatgtcaccc cagacgcttg gccaacctgg      120

ccagtcaagc tgggtgaatt gacacctaga ggtggtgagc tcatttgtta cttgggtcac      180

tactggagac agcgtcttgt tgccgacgaa ttgttgccta agtgtggttg tccacaatct      240

ggtcaagtag ctattattgc tgacgtcgac gaaagaaccc gtaagacagg tgaagccttc      300

gccgcctgtc ttgctcctga ctgtgccatt accgttcacc atcaagctga cacttcttct      360

ccagatccat tgttcaaccc tttgaagact ggtgtttgcc aattggacgt tgctaacgtt      420

actagagcta tcttggaaag agctggagga tctattgctg acttcaccgg tcactaccag      480

actgccttca gagagttgga aagagttctt aacttcccac aatccaactt gtgccttaag      540

cgtgagaagc aagacgaatc ctgttccttg actcaagcat taccatctga gttgaaggtc      600

tccgccgaca acgtctcttt gaccggtgct gtcagcttgg cttccatgtt gactgaaatc      660

tttcttctgc aacaagctca aggtatgcct gagccaggtt ggggtagaat caccgactct      720

caccaatgga acaccttgtt gtccttgcac aacgctcaat tcgatttgct gcagagaact      780

ccagaggttg ctagatccag agccacccca ttgttggact tgatcaagac tgctttgact      840

cctcacccac ctcaaaagca agcctacggt gttaccttgc ccacttctgt cttgttcatt      900

gccggtcacg atactaactt ggcaaatctc ggcggtgctt tggagttgaa ctggactctt      960

cctggtcaac ctgataacac tccaccaggt ggtgagctcg ttttcgaaag atggcgtaga     1020

ctatctgata actcttgttg gattcaggtt tcgttggtct tccaaacttt gcagcagatg     1080

agagacaaga ctccactgtc tttgaacacg cctccaggag aagtcaaatt gaccttggct     1140

ggatgtgaag agagaaatgc tcagggtatg tgttcctgtg ctggtttcac tcaaatcgtt     1200

aacgaagcta gaatcccagc ttgttccttg tag                                  1233


<210>  60
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-M1-CO

<400>  60
cagagtgagc ctgagttgaa actggaatcc gttgtcatcg tctctagaca tggtgttaga       60

gcaccaacca agttcaccca acttatgcaa gatgtcaccc cagacgcttg gccaacctgg      120

ccagtcaagc tgggtgaatt gacacctaga ggtggtgagc tcattgcttg tttgggtcac      180

tactggagac agcgtcttgt tgccgacgaa ttgttgccta agtgtggttg tccacaatct      240

ggtcaagtag ctattattgc tgacgtcgac gaaagaaccc gtaagacagg tgaagccttc      300

gccgccggtc ttgctcctga ctgtgccatt accgttcacc atcaagctga cacttcttct      360

ccagatccat tgttcaaccc tttgaagact ggtgtttgcc aattggacgt tgctaacgtt      420

actagagcta tcttggaaag agctggagga tctattgctg acttcaccgg tcactaccag      480

actgccttca gagagttgga aagagttctt aacttcccac aatccaactt gtgccttaag      540

cgtgagaagc aagacgaatc ctgttccttg actcaagcat taccatctga gttgaaggtc      600

tccgccgaca acgtctcttt gaccggtgct gtcagcttgg cttccatgtt gactgaaatc      660

tttcttctgc aacaagctca aggtatgcct gagccaggtt ggggtagaat caccgactct      720

caccaatgga acaccttgtt gtccttgcac aacgctcaat tcgatttgct gcagagaact      780

ccagaggttg ctagatccag agccacccca ttgttggact tgatcaagac tgctttgact      840

cctcacccac ctcaaaagca agcctacggt gttaccttgc ccacttctgt cttgttcatt      900

gccggtcacg atactaactt ggcaaatctc ggcggtgctt tggagttgaa ctggactctt      960

cctggtcaac ctgataacac tccaccaggt ggtgagctcg ttttcgaaag atggcgtaga     1020

ctatctgata actcttgttg gattcaggtt tcgttggtct tccaaacttt gcagcagatg     1080

agagacaaga ctccatgttc tttgaacacg cctccaggag aagtcaaatt gaccttggct     1140

ggatgtgaag agagaaatgc tcagggtatg tgttcctgtg ctggtttcac tcaaatcgtt     1200

aacgaagcta gaatcccagc ttgttccttg tag                                  1233


<210>  61
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-M1-DO

<400>  61
cagagtgagc ctgagttgaa actggaatcc gttgtcatcg tctctagaca tggtgttaga       60

gcaccaacca agttcaccca acttatgcaa gatgtcaccc cagacgcttg gccaacctgg      120

ccagtcaagc tgggtgaatt gacacctaga ggtggtgagc tcattgctta cttgggtcac      180

tgttggagac agcgtcttgt tgccgacgaa ttgttgccta agtgtggttg tccacaatct      240

ggtcaagtag ctattattgc tgacgtcgac gaaagaaccc gtaagacagg tgaagccttc      300

gccgccggtc ttgctcctga ctgtgccatt accgttcacc atcaagctga cacttcttct      360

ccagatccat tgttcaaccc tttgaagact ggtgtttgcc aattggacgt tgctaacgtt      420

actagagcta tcttggaaag agctggagga tctattgctg acttcaccgg tcactaccag      480

actgccttca gagagttgga aagagttctt aacttcccac aatccaactt gtgccttaag      540

cgtgagaagc aagacgaatc ctgttccttg actcaagcat taccatctga gttgaaggtc      600

tccgccgaca acgtctcttt gaccggtgct gtcagcttgg cttccatgtt gactgaaatc      660

tttcttctgc aacaagctca aggtatgcct gagccaggtt ggggtagaat caccgactct      720

caccaatgga acaccttgtt gtccttgcac aacgctcaat tcgatttgct gcagagaact      780

ccagaggttg ctagatccag agccacccca ttgttggact tgatcaagac tgctttgact      840

cctcacccac ctcaaaagca agcctacggt gttaccttgc ccacttctgt cttgttcatt      900

gccggtcacg atactaactt ggcaaatctc ggcggtgctt tggagttgaa ctggactctt      960

cctggtcaac ctgataacac tccaccaggt ggtgagctcg ttttcgaaag atggcgtaga     1020

ctatctgata actcttgttg gattcaggtt tcgttggtct tccaaacttt gcagcagatg     1080

agagacaaga ctccatgttc tttgaacacg cctccaggag aagtcaaatt gaccttggct     1140

ggatgtgaag agagaaatgc tcagggtatg tgttcctgtg ctggtttcac tcaaatcgtt     1200

aacgaagcta gaatcccagc ttgttccttg tag                                  1233


<210>  62
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-M1-MO

<400>  62
cagagtgagc ctgagttgaa actggaatcc gttgtcatcg tctctagaca tggtgttaga       60

gcaccaacca agttcaccca acttatgcaa gatgtcaccc cagacgcttg gccaacctgg      120

ccagtcaagc tgggtgaatt gacacctaga ggtggtgagc tcattgctta cttgggtcac      180

tactggagac agcgtcttgt tgccgacgaa ttgttgccta agtgtggttg tccacaatct      240

ggtcaagtag ctattattgc tgacgtcgac gaaagaaccc gtaagacagg tgaagccttc      300

gccgccggtc ttgctcctga ctgtgccatt accgttcacc atcaagctga cacttcttct      360

ccagatccat tgttcaaccc tttgaagact ggtgtttgcc aattggacgt tgctaacgtt      420

actagagcta tcttggaaag agctggagga tctattgctg acttcaccgg tcactaccag      480

actgccttca gagagttgga aagagttctt aacttcccac aatccaactt gtgccttaag      540

cgtgagaagc aagacgaatc ctgttccttg actcaagcat taccatctga gttgaaggtc      600

tccgccgaca acgtctcttt gaccggtgct gtcagcttgg cttccatgtt gactgaaatc      660

tttcttctgc aacaagctca aggtatgcct gagccaggtt ggggtagaat caccgactct      720

caccaatgga acaccttgtt gtccttgcac aacgctcaat tcgatttgct gcagagaact      780

ccagaggttg ctagatccag agccacccca ttgttggact tgatcaagac tgctttgact      840

cctcacccac ctcaaaagca agcctacggt gttaccttgc ccacttctgt cttgttcatt      900

gccggtcacg atactaactt ggcaaatctc ggcggtgctt tgtgtttgaa ctggactctt      960

cctggtcaac ctgataacac tccaccaggt ggtgagctcg ttttcgaaag atggcgtaga     1020

ctatctgata actcttgttg gattcaggtt tcgttggtct tccaaacttt gcagcagatg     1080

agagacaaga ctccactgtc tttgaacacg cctccaggag aagtcaaatt gaccttgtgt     1140

ggatgtgaag agagaaatgc tcagggtatg tgttcctgtg ctggtttcac tcaaatcgtt     1200

aacgaagcta gaatcccagc ttgttccttg tag                                  1233


<210>  63
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-M1-BDO

<400>  63
cagagtgagc ctgagttgaa actggaatcc gttgtcatcg tctctagaca tggtgttaga       60

gcaccaacca agttcaccca acttatgcaa gatgtcaccc cagacgcttg gccaacctgg      120

ccagtcaagc tgggtgaatt gacacctaga ggtggtgagc tcatttgtta cttgggtcac      180

tgttggagac agcgtcttgt tgccgacgaa ttgttgccta agtgtggttg tccacaatct      240

ggtcaagtag ctattattgc tgacgtcgac gaaagaaccc gtaagacagg tgaagccttc      300

gccgcctgtc ttgctcctga ctgtgccatt accgttcacc atcaagctga cacttcttct      360

ccagatccat tgttcaaccc tttgaagact ggtgtttgcc aattggacgt tgctaacgtt      420

actagagcta tcttggaaag agctggagga tctattgctg acttcaccgg tcactaccag      480

actgccttca gagagttgga aagagttctt aacttcccac aatccaactt gtgccttaag      540

cgtgagaagc aagacgaatc ctgttccttg actcaagcat taccatctga gttgaaggtc      600

tccgccgaca acgtctcttt gaccggtgct gtcagcttgg cttccatgtt gactgaaatc      660

tttcttctgc aacaagctca aggtatgcct gagccaggtt ggggtagaat caccgactct      720

caccaatgga acaccttgtt gtccttgcac aacgctcaat tcgatttgct gcagagaact      780

ccagaggttg ctagatccag agccacccca ttgttggact tgatcaagac tgctttgact      840

cctcacccac ctcaaaagca agcctacggt gttaccttgc ccacttctgt cttgttcatt      900

gccggtcacg atactaactt ggcaaatctc ggcggtgctt tggagttgaa ctggactctt      960

cctggtcaac ctgataacac tccaccaggt ggtgagctcg ttttcgaaag atggcgtaga     1020

ctatctgata actcttgttg gattcaggtt tcgttggtct tccaaacttt gcagcagatg     1080

agagacaaga ctccatgttc tttgaacacg cctccaggag aagtcaaatt gaccttggct     1140

ggatgtgaag agagaaatgc tcagggtatg tgttcctgtg ctggtttcac tcaaatcgtt     1200

aacgaagcta gaatcccagc ttgttccttg tag                                  1233


<210>  64
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-M1-DMO

<400>  64
cagagtgagc ctgagttgaa actggaatcc gttgtcatcg tctctagaca tggtgttaga       60

gcaccaacca agttcaccca acttatgcaa gatgtcaccc cagacgcttg gccaacctgg      120

ccagtcaagc tgggtgaatt gacacctaga ggtggtgagc tcattgctta cttgggtcac      180

tgttggagac agcgtcttgt tgccgacgaa ttgttgccta agtgtggttg tccacaatct      240

ggtcaagtag ctattattgc tgacgtcgac gaaagaaccc gtaagacagg tgaagccttc      300

gccgccggtc ttgctcctga ctgtgccatt accgttcacc atcaagctga cacttcttct      360

ccagatccat tgttcaaccc tttgaagact ggtgtttgcc aattggacgt tgctaacgtt      420

actagagcta tcttggaaag agctggagga tctattgctg acttcaccgg tcactaccag      480

actgccttca gagagttgga aagagttctt aacttcccac aatccaactt gtgccttaag      540

cgtgagaagc aagacgaatc ctgttccttg actcaagcat taccatctga gttgaaggtc      600

tccgccgaca acgtctcttt gaccggtgct gtcagcttgg cttccatgtt gactgaaatc      660

tttcttctgc aacaagctca aggtatgcct gagccaggtt ggggtagaat caccgactct      720

caccaatgga acaccttgtt gtccttgcac aacgctcaat tcgatttgct gcagagaact      780

ccagaggttg ctagatccag agccacccca ttgttggact tgatcaagac tgctttgact      840

cctcacccac ctcaaaagca agcctacggt gttaccttgc ccacttctgt cttgttcatt      900

gccggtcacg atactaactt ggcaaatctc ggcggtgctt tgtgtttgaa ctggactctt      960

cctggtcaac ctgataacac tccaccaggt ggtgagctcg ttttcgaaag atggcgtaga     1020

ctatctgata actcttgttg gattcaggtt tcgttggtct tccaaacttt gcagcagatg     1080

agagacaaga ctccatgttc tttgaacacg cctccaggag aagtcaaatt gaccttgtgt     1140

ggatgtgaag agagaaatgc tcagggtatg tgttcctgtg ctggtttcac tcaaatcgtt     1200

aacgaagcta gaatcccagc ttgttccttg tag                                  1233


<210>  65
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPAan-A

<400>  65
cagtccgagc ccgagctcaa gctcgagtcc gtcgtcatcg tctcccgcca cggtgtccgc       60

gcccccacca aggccaccca gctcatgcag gacgtcacct gcgacgcctg gcccacctgg      120

cccgtcaagc tcggttggct caccccccgc ggtggtgagc tcatcgccta cctcggtcac      180

taccagcgcc agcgcctcgt cgccgacggt ctcctcgcca agaagggttg cccccagtcc      240

ggtcaggtcg ccatcatcgc cgacgtcgac gagcgcaccc gcaagaccgg tgaggccttc      300

gccgccggtc tcgcccccga ctgcgccatc accgtccaca cccaggccga cacctcctcc      360

cccgaccccc tcttcaaccc cctcaagacc ggtgtctgcc agctcgacaa cgccaacgtc      420

accgacgcca tcctctcccg cgccggtggt tccatcgccg acttcaccgg tcaccgccag      480

accgccttcc gcgagctcga gcgcgtcctc aacttcccct gctccaacct ctgcctcaag      540

cgcgagaagc aggacgagtc ctgctccctc acccaggccc tcccctccga gctcaaggtc      600

tccgccgaca acgtctccct caccggtgcc gtctccctcg cctccatgct caccgagatc      660

ttcctcctcc agcaggccca gggtatgccc gagcccggtt ggggtcgcat caccgactcc      720

caccagtgga acaccctcct ctccctccac aacgcccagt tctacctcct ccagcgcacc      780

cccgaggtcg cccgctcccg cgccaccccc ctcctcgacc tcatcaagac cgccctcacc      840

ccccaccccc cccagaagca ggcctacggt gtcaccctcc ccacctccgt cctcttcatc      900

gccggtcacg acaccaacct cgccaacctc ggtggtgccc tcgagctcaa ctggaccctc      960

cccggtcagc ccgacaacac cccccccggt ggtgagctcg tcttcgagcg ctggcgccgc     1020

ctctccgaca actcccagtg gatccaggtc tccctcgtct tccagaccct ccagcagatg     1080

cgcgacaaga cccccctctc cctcaacacc ccccccggtg aggtcaagct caccctcgcc     1140

ggttgcgagg agcgcaacgc ccagggtatg tgctccctcg ccggtttcac ccagatcgtc     1200

aacgaggccc gcatccccgc ctgctccctc taa                                  1233


<210>  66
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPAan-B

<400>  66
cagtccgagc ccgagctcaa gctcgagtcc gtcgtcatcg tctcccgcca cggtgtccgc       60

gcccccacca aggccaccca gctcatgcag gacgtcaccc ccgacgcctg gcccacctgg      120

cccgtcaagc tcggttggct caccccccgc ggtggtgagc tcatctgcta cctcggtcac      180

taccagcgcc agcgcctcgt cgccgacggt ctcctcgcca agaagggttg cccccagtcc      240

ggtcaggtcg ccatcatcgc cgacgtcgac gagcgcaccc gcaagaccgg tgaggccttc      300

gccgcctgcc tcgcccccga ctgcgccatc accgtccaca cccaggccga cacctcctcc      360

cccgaccccc tcttcaaccc cctcaagacc ggtgtctgcc agctcgacaa cgccaacgtc      420

accgacgcca tcctctcccg cgccggtggt tccatcgccg acttcaccgg tcaccgccag      480

accgccttcc gcgagctcga gcgcgtcctc aacttccccc agtccaacct ctgcctcaag      540

cgcgagaagc aggacgagtc ctgctccctc acccaggccc tcccctccga gctcaaggtc      600

tccgccgaca acgtctccct caccggtgcc gtctccctcg cctccatgct caccgagatc      660

ttcctcctcc agcaggccca gggtatgccc gagcccggtt ggggtcgcat caccgactcc      720

caccagtgga acaccctcct ctccctccac aacgcccagt tctacctcct ccagcgcacc      780

cccgaggtcg cccgctcccg cgccaccccc ctcctcgacc tcatcaagac cgccctcacc      840

ccccaccccc cccagaagca ggcctacggt gtcaccctcc ccacctccgt cctcttcatc      900

gccggtcacg acaccaacct cgccaacctc ggtggtgccc tcgagctcaa ctggaccctc      960

cccggtcagc ccgacaacac cccccccggt ggtgagctcg tcttcgagcg ctggcgccgc     1020

ctctccgaca actcccagtg gatccaggtc tccctcgtct tccagaccct ccagcagatg     1080

cgcgacaaga cccccctctc cctcaacacc ccccccggtg aggtcaagct caccctcgcc     1140

ggttgcgagg agcgcaacgc ccagggtatg tgctccctcg ccggtttcac ccagatcgtc     1200

aacgaggccc gcatccccgc ctgctccctc taa                                  1233


<210>  67
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPAan-C

<400>  67
cagtccgagc ccgagctcaa gctcgagtcc gtcgtcatcg tctcccgcca cggtgtccgc       60

gcccccacca aggccaccca gctcatgcag gacgtcaccc ccgacgcctg gcccacctgg      120

cccgtcaagc tcggttggct caccccccgc ggtggtgagc tcatcgcctg cctcggtcac      180

taccagcgcc agcgcctcgt cgccgacggt ctcctcgcca agaagggttg cccccagtcc      240

ggtcaggtcg ccatcatcgc cgacgtcgac gagcgcaccc gcaagaccgg tgaggccttc      300

gccgccggtc tcgcccccga ctgcgccatc accgtccaca cccaggccga cacctcctcc      360

cccgaccccc tcttcaaccc cctcaagacc ggtgtctgcc agctcgacaa cgccaacgtc      420

accgacgcca tcctctcccg cgccggtggt tccatcgccg acttcaccgg tcaccgccag      480

accgccttcc gcgagctcga gcgcgtcctc aacttccccc agtccaacct ctgcctcaag      540

cgcgagaagc aggacgagtc ctgctccctc acccaggccc tcccctccga gctcaaggtc      600

tccgccgaca acgtctccct caccggtgcc gtctccctcg cctccatgct caccgagatc      660

ttcctcctcc agcaggccca gggtatgccc gagcccggtt ggggtcgcat caccgactcc      720

caccagtgga acaccctcct ctccctccac aacgcccagt tctacctcct ccagcgcacc      780

cccgaggtcg cccgctcccg cgccaccccc ctcctcgacc tcatcaagac cgccctcacc      840

ccccaccccc cccagaagca ggcctacggt gtcaccctcc ccacctccgt cctcttcatc      900

gccggtcacg acaccaacct cgccaacctc ggtggtgccc tcgagctcaa ctggaccctc      960

cccggtcagc ccgacaacac cccccccggt ggtgagctcg tcttcgagcg ctggcgccgc     1020

ctctccgaca actcccagtg gatccaggtc tccctcgtct tccagaccct ccagcagatg     1080

cgcgacaaga ccccctgctc cctcaacacc ccccccggtg aggtcaagct caccctcgcc     1140

ggttgcgagg agcgcaacgc ccagggtatg tgctccctcg ccggtttcac ccagatcgtc     1200

aacgaggccc gcatccccgc ctgctccctc taa                                  1233


<210>  68
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPAan-D

<400>  68
cagtccgagc ccgagctcaa gctcgagtcc gtcgtcatcg tctcccgcca cggtgtccgc       60

gcccccacca aggccaccca gctcatgcag gacgtcaccc ccgacgcctg gcccacctgg      120

cccgtcaagc tcggttggct caccccccgc ggtggtgagc tcatcgccta cctcggtcac      180

tgccagcgcc agcgcctcgt cgccgacggt ctcctcgcca agaagggttg cccccagtcc      240

ggtcaggtcg ccatcatcgc cgacgtcgac gagcgcaccc gcaagaccgg tgaggccttc      300

gccgccggtc tcgcccccga ctgcgccatc accgtccaca cccaggccga cacctcctcc      360

cccgaccccc tcttcaaccc cctcaagacc ggtgtctgcc agctcgacaa cgccaacgtc      420

accgacgcca tcctctcccg cgccggtggt tccatcgccg acttcaccgg tcaccgccag      480

accgccttcc gcgagctcga gcgcgtcctc aacttccccc agtccaacct ctgcctcaag      540

cgcgagaagc aggacgagtc ctgctccctc acccaggccc tcccctccga gctcaaggtc      600

tccgccgaca acgtctccct caccggtgcc gtctccctcg cctccatgct caccgagatc      660

ttcctcctcc agcaggccca gggtatgccc gagcccggtt ggggtcgcat caccgactcc      720

caccagtgga acaccctcct ctccctccac aacgcccagt tctacctcct ccagcgcacc      780

cccgaggtcg cccgctcccg cgccaccccc ctcctcgacc tcatcaagac cgccctcacc      840

ccccaccccc cccagaagca ggcctacggt gtcaccctcc ccacctccgt cctcttcatc      900

gccggtcacg acaccaacct cgccaacctc ggtggtgccc tcgagctcaa ctggaccctc      960

cccggtcagc ccgacaacac cccccccggt ggtgagctcg tcttcgagcg ctggcgccgc     1020

ctctccgaca actcccagtg gatccaggtc tccctcgtct tccagaccct ccagcagatg     1080

cgcgacaaga ccccctgctc cctcaacacc ccccccggtg aggtcaagct caccctcgcc     1140

ggttgcgagg agcgcaacgc ccagggtatg tgctccctcg ccggtttcac ccagatcgtc     1200

aacgaggccc gcatccccgc ctgctccctc taa                                  1233


<210>  69
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPAan-E

<400>  69
cagtccgagc ccgagctcaa gctcgagtcc gtcgtcatcg tctcccgcca cggtgtccgc       60

gcccccacca aggccaccca gctcatgcag gacgtcaccc ccgacgcctg gcccacctgg      120

cccgtcaagc tcggttggct caccccccgc ggtggtgagc tcatcgccta cctcggtcac      180

taccagcgcc agcgcctcgt cgccgacggt ctcctcgcca agaagggttg cccccagtcc      240

ggttgcgtcg ccatcatcgc cgacgtcgac gagcgcaccc gcaagaccgg tgaggccttc      300

gccgccggtc tcgcccccga ctgcgccatc accgtccaca cccaggccga cacctcctcc      360

cccgaccccc tcttcaaccc cctcaagacc ggtgtctgcc agctcgacaa cgccaacgtc      420

accgacgcca tcctctcccg cgccggtggt tccatcgccg acttcaccgg tcaccgccag      480

accgccttcc gcgagctcga gcgcgtcctc aacttccccc agtccaacct ctgcctcaag      540

cgcgagaagc aggacgagtc ctgctccctc acccaggccc tcccctccga gctcaaggtc      600

tccgccgaca acgtctccct caccggtgcc gtctccctcg cctccatgct caccgagatc      660

ttcctcctcc agcaggccca gggtatgccc gagcccggtt ggggtcgcat caccgactcc      720

caccagtgga acaccctcct ctccctccac aacgcccagt tctacctcct ccagcgcacc      780

cccgaggtcg cccgctcccg cgccaccccc ctcctcgacc tcatcaagac cgccctcacc      840

ccccaccccc cccagaagca ggcctacggt gtcaccctcc ccacctgcgt cctcttcatc      900

gccggtcacg acaccaacct cgccaacctc ggtggtgccc tcgagctcaa ctggaccctc      960

cccggtcagc ccgacaacac cccccccggt ggtgagctcg tcttcgagcg ctggcgccgc     1020

ctctccgaca actcccagtg gatccaggtc tccctcgtct tccagaccct ccagcagatg     1080

cgcgacaaga cccccctctc cctcaacacc ccccccggtg aggtcaagct caccctcgcc     1140

ggttgcgagg agcgcaacgc ccagggtatg tgctccctcg ccggtttcac ccagatcgtc     1200

aacgaggccc gcatccccgc ctgctccctc taa                                  1233


<210>  70
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPAan-F

<400>  70
cagtccgagc ccgagctcaa gctcgagtcc gtcgtcatcg tctcccgcca cggtgtccgc       60

gcccccacca aggccaccca gctcatgcag gacgtcaccc ccgacgcctg gcccacctgg      120

cccgtcaagc tcggttggct caccccccgc ggtggtgagc tcatcgccta cctcggtcac      180

taccagcgcc agcgcctcgt cgccgacggt ctcctcgcca agaagggttg cccccagtcc      240

ggtcaggtcg ccatcatcgc cgacgtcgac gagcgcaccc gcaagaccgg tgaggccttc      300

gccgccggtc tcgcccccga ctgcgccatc accgtccaca cccaggccga cacctcctcc      360

cccgaccccc tcttcaaccc ctgcaagacc ggtgtctgcc agctcgacaa cgccaacgtc      420

accgacgcca tcctctcccg cgccggtggt tccatcgccg acttcaccgg tcaccgccag      480

accgccttcc gcgagctcga gcgcgtcctc aacttccccc agtccaacct ctgcctcaag      540

cgcgagaagc aggacgagtc ctgctccctc acccaggccc tcccctccga gctcaaggtc      600

tccgcctgca acgtctccct caccggtgcc gtctccctcg cctccatgct caccgagatc      660

ttcctcctcc agcaggccca gggtatgccc gagcccggtt ggggtcgcat caccgactcc      720

caccagtgga acaccctcct ctccctccac aacgcccagt tctacctcct ccagcgcacc      780

cccgaggtcg cccgctcccg cgccaccccc ctcctcgacc tcatcaagac cgccctcacc      840

ccccaccccc cccagaagca ggcctacggt gtcaccctcc ccacctccgt cctcttcatc      900

gccggtcacg acaccaacct cgccaacctc ggtggtgccc tcgagctcaa ctggaccctc      960

cccggtcagc ccgacaacac cccccccggt ggtgagctcg tcttcgagcg ctggcgccgc     1020

ctctccgaca actcccagtg gatccaggtc tccctcgtct tccagaccct ccagcagatg     1080

cgcgacaaga cccccctctc cctcaacacc ccccccggtg aggtcaagct caccctcgcc     1140

ggttgcgagg agcgcaacgc ccagggtatg tgctccctcg ccggtttcac ccagatcgtc     1200

aacgaggccc gcatccccgc ctgctccctc taa                                  1233


<210>  71
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPAan-I

<400>  71
cagtccgagc ccgagctcaa gctcgagtcc gtcgtcatcg tctcccgcca cggtgtccgc       60

gcccccacca aggccaccca gctcatgcag gacgtcaccc ccgacgcctg gcccacctgg      120

cccgtcaagc tcggttggct caccccccgc ggtggtgagc tcatcgccta cctcggtcac      180

taccagcgcc agcgcctcgt cgccgacggt ctcctcgcca agaagggttg cccccagtcc      240

ggtcaggtcg ccatcatcgc cgacgtcgac gagcgcaccc gcaagaccgg tgaggccttc      300

gccgccggtc tcgcccccga ctgcgccatc accgtccaca cccaggccga cacctcctcc      360

cccgaccccc tcttcaaccc cctcaagacc ggtgtctgcc agctcgacaa cgccaacgtc      420

accgacgcca tcctctcccg cgccggtggt tccatcgccg acttcaccgg tcaccgccag      480

accgccttcc gctgcctcga gcgcgtcctc aacttccccc agtccaacct ctgcctcaag      540

cgcgagaagc aggacgagtc ctgctccctc acccaggccc tcccctccga gctcaaggtc      600

tccgccgaca acgtctccct caccggtgcc gtctccctcg cctccatgct caccgagatc      660

ttcctcctcc agcaggccca gggtatgccc gagcccggtt ggggtcgcat caccgactcc      720

caccagtgga actgcctcct ctccctccac aacgcccagt tctacctcct ccagcgcacc      780

cccgaggtcg cccgctcccg cgccaccccc ctcctcgacc tcatcaagac cgccctcacc      840

ccccaccccc cccagaagca ggcctacggt gtcaccctcc ccacctccgt cctcttcatc      900

gccggtcacg acaccaacct cgccaacctc ggtggtgccc tcgagctcaa ctggaccctc      960

cccggtcagc ccgacaacac cccccccggt ggtgagctcg tcttcgagcg ctggcgccgc     1020

ctctccgaca actcccagtg gatccaggtc tccctcgtct tccagaccct ccagcagatg     1080

cgcgacaaga cccccctctc cctcaacacc ccccccggtg aggtcaagct caccctcgcc     1140

ggttgcgagg agcgcaacgc ccagggtatg tgctccctcg ccggtttcac ccagatcgtc     1200

aacgaggccc gcatccccgc ctgctccctc taa                                  1233


<210>  72
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPAan-J

<400>  72
cagtccgagc ccgagctcaa gctcgagtcc gtcgtcatcg tctcccgcca cggtgtccgc       60

gcccccacca aggccaccca gctcatgcag gacgtcaccc ccgacgcctg gcccacctgg      120

cccgtcaagc tcggttggct caccccccgc ggtggtgagc tcatcgccta cctcggtcac      180

taccagcgcc agcgcctcgt cgccgacggt ctcctcgcca agaagggttg cccccagtcc      240

ggtcaggtcg ccatcatcgc cgacgtcgac gagcgcaccc gcaagaccgg tgaggccttc      300

gccgccggtc tcgcccccga ctgcgccatc accgtccaca cccaggccga cacctcctcc      360

cccgaccccc tcttcaaccc cctcaagacc ggtgtctgcc agctcgacaa cgccaacgtc      420

accgacgcca tcctctcccg cgccggtggt tccatcgccg acttcaccgg tcaccgccag      480

accgccttcc gcgagctcga gcgcgtcctc aacttccccc agtccaacct ctgcctcaag      540

cgcgagaagc aggacgagtc ctgctccctc tgccaggccc tcccctccga gctcaaggtc      600

tccgccgaca acgtctccct caccggtgcc gtctccctcg cctccatgct caccgagatc      660

ttcctcctcc agcaggccca gggtatgccc gagcccggtt ggggtcgcat caccgactgc      720

caccagtgga acaccctcct ctccctccac aacgcccagt tctacctcct ccagcgcacc      780

cccgaggtcg cccgctcccg cgccaccccc ctcctcgacc tcatcaagac cgccctcacc      840

ccccaccccc cccagaagca ggcctacggt gtcaccctcc ccacctccgt cctcttcatc      900

gccggtcacg acaccaacct cgccaacctc ggtggtgccc tcgagctcaa ctggaccctc      960

cccggtcagc ccgacaacac cccccccggt ggtgagctcg tcttcgagcg ctggcgccgc     1020

ctctccgaca actcccagtg gatccaggtc tccctcgtct tccagaccct ccagcagatg     1080

cgcgacaaga cccccctctc cctcaacacc ccccccggtg aggtcaagct caccctcgcc     1140

ggttgcgagg agcgcaacgc ccagggtatg tgctccctcg ccggtttcac ccagatcgtc     1200

aacgaggccc gcatccccgc ctgctccctc taa                                  1233


<210>  73
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPAan-K

<400>  73
cagtccgagc ccgagctcaa gctcgagtcc gtcgtcatcg tctcccgcca cggtgtccgc       60

gcccccacca aggccaccca gctcatgcag gacgtcaccc ccgacgcctg gcccacctgg      120

cccgtcaagc tcggttggct caccccccgc ggtggtgagc tcatcgccta cctcggtcac      180

taccagcgcc agcgcctcgt cgccgacggt ctcctcgcca agaagggttg cccccagtcc      240

ggtcaggtcg ccatcatcgc cgacgtcgac gagcgcaccc gcaagaccgg tgaggccttc      300

gccgccggtc tcgcccccga ctgcgccatc accgtccaca cccaggccga cacctcctcc      360

cccgaccccc tcttcaaccc cctcaagacc ggtgtctgcc agctcgacaa cgccaacgtc      420

accgacgcca tcctctcccg cgccggtggt tccatcgccg acttcaccgg tcaccgccag      480

accgccttcc gcgagctcga gcgcgtcctc aacttccccc agtccaacct ctgcctcaag      540

cgcgagaagc aggacgagtc ctgctccctc acccaggccc tcccctgcga gctcaaggtc      600

tccgccgaca acgtctccct caccggtgcc tgctccctcg cctccatgct caccgagatc      660

ttcctcctcc agcaggccca gggtatgccc gagcccggtt ggggtcgcat caccgactcc      720

caccagtgga acaccctcct ctccctccac aacgcccagt tctacctcct ccagcgcacc      780

cccgaggtcg cccgctcccg cgccaccccc ctcctcgacc tcatcaagac cgccctcacc      840

ccccaccccc cccagaagca ggcctacggt gtcaccctcc ccacctccgt cctcttcatc      900

gccggtcacg acaccaacct cgccaacctc ggtggtgccc tcgagctcaa ctggaccctc      960

cccggtcagc ccgacaacac cccccccggt ggtgagctcg tcttcgagcg ctggcgccgc     1020

ctctccgaca actcccagtg gatccaggtc tccctcgtct tccagaccct ccagcagatg     1080

cgcgacaaga cccccctctc cctcaacacc ccccccggtg aggtcaagct caccctcgcc     1140

ggttgcgagg agcgcaacgc ccagggtatg tgctccctcg ccggtttcac ccagatcgtc     1200

aacgaggccc gcatccccgc ctgctccctc taa                                  1233


<210>  74
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPAan-L

<400>  74
cagtccgagc ccgagctcaa gctcgagtcc gtcgtcatcg tctcccgcca cggtgtccgc       60

gcccccacca aggccaccca gctcatgcag gacgtcaccc ccgacgcctg gcccacctgg      120

cccgtcaagc tcggttggct caccccccgc ggtggtgagc tcatcgccta cctcggtcac      180

taccagcgcc agcgcctcgt cgccgacggt ctcctcgcca agaagggttg cccccagtcc      240

ggtcaggtcg ccatcatcgc cgacgtcgac gagcgcaccc gcaagaccgg tgaggccttc      300

gccgccggtc tcgcccccga ctgcgccatc accgtccaca cccaggccga cacctcctcc      360

cccgaccccc tcttcaaccc cctcaagacc ggtgtctgcc agctcgacaa cgccaacgtc      420

accgacgcca tcctctcccg cgccggtggt tccatcgccg acttcaccgg tcaccgccag      480

accgccttcc gcgagctcga gcgcgtcctc aacttccccc agtccaacct ctgcctcaag      540

cgcgagaagc aggacgagtc ctgctccctc acccaggccc tcccctccga gctcaaggtc      600

tccgccgaca acgtctccct caccggtgcc gtctccctcg cctccatgct caccgagatc      660

ttcctcctcc agcaggccca gggtatgccc gagcccggtt ggggtcgcat caccgactcc      720

caccagtgga acaccctcct ctccctccac aacgcccagt tctacctcct ccagcgcacc      780

cccgaggtct gccgctcccg cgccaccccc ctcctcgacc tcatcaagac cgccctcacc      840

ccccaccccc cccagaagca ggcctacggt gtcaccctcc ccacctccgt cctcttcatc      900

gccggtcacg acaccaacct cgccaacctc ggttgcgccc tcgagctcaa ctggaccctc      960

cccggtcagc ccgacaacac cccccccggt ggtgagctcg tcttcgagcg ctggcgccgc     1020

ctctccgaca actcccagtg gatccaggtc tccctcgtct tccagaccct ccagcagatg     1080

cgcgacaaga cccccctctc cctcaacacc ccccccggtg aggtcaagct caccctcgcc     1140

ggttgcgagg agcgcaacgc ccagggtatg tgctccctcg ccggtttcac ccagatcgtc     1200

aacgaggccc gcatccccgc ctgctccctc taa                                  1233


<210>  75
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPAan-M

<400>  75
cagtccgagc ccgagctcaa gctcgagtcc gtcgtcatcg tctcccgcca cggtgtccgc       60

gcccccacca aggccaccca gctcatgcag gacgtcaccc ccgacgcctg gcccacctgg      120

cccgtcaagc tcggttggct caccccccgc ggtggtgagc tcatcgccta cctcggtcac      180

taccagcgcc agcgcctcgt cgccgacggt ctcctcgcca agaagggttg cccccagtcc      240

ggtcaggtcg ccatcatcgc cgacgtcgac gagcgcaccc gcaagaccgg tgaggccttc      300

gccgccggtc tcgcccccga ctgcgccatc accgtccaca cccaggccga cacctcctcc      360

cccgaccccc tcttcaaccc cctcaagacc ggtgtctgcc agctcgacaa cgccaacgtc      420

accgacgcca tcctctcccg cgccggtggt tccatcgccg acttcaccgg tcaccgccag      480

accgccttcc gcgagctcga gcgcgtcctc aacttccccc agtccaacct ctgcctcaag      540

cgcgagaagc aggacgagtc ctgctccctc acccaggccc tcccctccga gctcaaggtc      600

tccgccgaca acgtctccct caccggtgcc gtctccctcg cctccatgct caccgagatc      660

ttcctcctcc agcaggccca gggtatgccc gagcccggtt ggggtcgcat caccgactcc      720

caccagtgga acaccctcct ctccctccac aacgcccagt tctacctcct ccagcgcacc      780

cccgaggtcg cccgctcccg cgccaccccc ctcctcgacc tcatcaagac cgccctcacc      840

ccccaccccc cccagaagca ggcctacggt gtcaccctcc ccacctccgt cctcttcatc      900

gccggtcacg acaccaacct cgccaacctc ggtggtgccc tctgcctcaa ctggaccctc      960

cccggtcagc ccgacaacac cccccccggt ggtgagctcg tcttcgagcg ctggcgccgc     1020

ctctccgaca actcccagtg gatccaggtc tccctcgtct tccagaccct ccagcagatg     1080

cgcgacaaga cccccctctc cctcaacacc ccccccggtg aggtcaagct caccctctgc     1140

ggttgcgagg agcgcaacgc ccagggtatg tgctccctcg ccggtttcac ccagatcgtc     1200

aacgaggccc gcatccccgc ctgctccctc taa                                  1233


<210>  76
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPAan-N

<400>  76
cagtccgagc ccgagctcaa gctcgagtcc gtcgtcatcg tctcccgcca cggtgtccgc       60

gcccccacca aggccaccca gctcatgcag gacgtcaccc ccgacgcctg gcccacctgg      120

cccgtcaagc tcggttggct caccccccgc ggtggtgagc tcatcgccta cctcggtcac      180

taccagcgcc agcgcctcgt cgccgacggt ctcctcgcca agaagggttg cccccagtcc      240

ggtcaggtcg ccatcatcgc cgacgtcgac gagcgcaccc gcaagaccgg tgaggccttc      300

gccgccggtc tcgcccccga ctgcgccatc accgtccaca cccaggccga cacctcctcc      360

cccgaccccc tcttcaaccc cctcaagacc ggtgtctgcc agctcgacaa cgccaacgtc      420

accgacgcca tcctctcccg cgccggtggt tccatcgccg acttcaccgg tcaccgccag      480

accgccttcc gcgagctcga gcgcgtcctc aacttccccc agtccaacct ctgcctcaag      540

cgcgagaagc aggacgagtc ctgctccctc acccaggccc tcccctccga gctcaaggtc      600

tccgccgaca acgtctccct caccggtgcc gtctccctcg cctccatgct caccgagatc      660

ttcctcctcc agcaggccca gggtatgccc gagcccggtt ggggtcgcat caccgactcc      720

caccagtgga acaccctcct ctccctccac aacgcccagt tctacctcct ccagcgcacc      780

cccgaggtcg cccgctcccg cgccaccccc ctcctcgacc tcatcaagac cgccctcacc      840

ccccaccccc cccagaagca ggcctacggt gtcaccctcc ccacctccgt cctcttcatc      900

gccggtcacg acaccaacct cgccaacctc ggtggtgccc tcgagctcaa ctggaccctc      960

ccctgccagc ccgacaacac cccccccggt ggtgagctcg tcttcgagcg ctggcgccgc     1020

ctctccgaca actcccagtg gatccaggtc tccctcgtct tccagtgcct ccagcagatg     1080

cgcgacaaga cccccctctc cctcaacacc ccccccggtg aggtcaagct caccctcgcc     1140

ggttgcgagg agcgcaacgc ccagggtatg tgctccctcg ccggtttcac ccagatcgtc     1200

aacgaggccc gcatccccgc ctgctccctc taa                                  1233


<210>  77
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPAan-O

<400>  77
cagtccgagc ccgagctcaa gctcgagtcc gtcgtcatcg tctcccgcca cggtgtccgc       60

gcccccacca aggccaccca gctcatgcag gacgtcaccc ccgacgcctg gcccacctgg      120

cccgtcaagc tcggttggct caccccccgc ggtggtgagc tcatcgccta cctcggtcac      180

taccagcgcc agcgcctcgt cgccgacggt ctcctcgcca agaagggttg cccccagtcc      240

ggtcaggtcg ccatcatcgc cgacgtcgac gagcgcaccc gcaagaccgg tgaggccttc      300

gccgccggtc tcgcccccga ctgcgccatc accgtccaca cccaggccga cacctcctcc      360

cccgaccccc tcttcaaccc cctcaagacc ggtgtctgcc agctcgacaa cgccaacgtc      420

accgacgcca tcctctcccg cgccggtggt tccatcgccg acttcaccgg tcaccgccag      480

accgccttcc gcgagctcga gcgcgtcctc aacttccccc agtccaacct ctgcctcaag      540

cgcgagaagc aggacgagtc ctgctccctc acccaggccc tcccctccga gctcaaggtc      600

tccgccgaca acgtctccct caccggtgcc gtctccctcg cctccatgct caccgagatc      660

ttcctcctcc agcaggccca gggtatgccc gagcccggtt ggggtcgcat caccgactcc      720

caccagtgga acaccctcct ctccctccac aacgcccagt tctacctcct ccagcgcacc      780

cccgaggtcg cccgctcccg cgccaccccc ctcctcgacc tcatcaagac cgccctcacc      840

ccccaccccc cccagaagca ggcctacggt gtcaccctcc ccacctccgt cctcttcatc      900

gccggtcacg acaccaacct cgccaacctc ggtggtgccc tcgagctcaa ctggaccctc      960

cccggtcagc ccgacaacac cccccccggt ggtgagctcg tcttcgagcg ctggcgccgc     1020

ctctccgaca actcctgctg gatccaggtc tccctcgtct tccagaccct ccagcagatg     1080

cgcgacaaga cccccctctc cctcaacacc ccccccggtg aggtcaagct caccctcgcc     1140

ggttgcgagg agcgcaacgc ccagggtatg tgctcctgcg ccggtttcac ccagatcgtc     1200

aacgaggccc gcatccccgc ctgctccctc taa                                  1233


<210>  78
<211>  1233
<212>  DNA
<213>  Aspergillus niger

<400>  78
cagagtgagc ctgagttgaa actggaatcc gttgtcatcg tctctagaca tggtgttaga       60

gcaccaacca aggccaccca acttatgcaa gatgtcaccc cagacgcttg gccaacctgg      120

ccagtcaagc tgggttggtt gacacctaga ggtggtgagc tcattgctta cttgggtcac      180

taccaaagac agcgtcttgt tgccgacgga ttgttggcca agaagggttg tccacaatct      240

ggtcaagtag ctattattgc tgacgtcgac gaaagaaccc gtaagacagg tgaagccttc      300

gccgccggtc ttgctcctga ctgtgccatt accgttcaca cccaagctga cacttcttct      360

ccagatccat tgttcaaccc tttgaagact ggtgtttgcc aattggacaa cgctaacgtt      420

actgacgcta tcttgtccag agctggagga tccattgctg acttcaccgg tcacagacag      480

actgccttca gagagttgga aagagttctt aacttcccac aatcaaactt gtgcttgaag      540

cgtgagaagc aagacgaatc ctgttccttg actcaagcat taccatctga gttgaaggtc      600

tccgccgaca acgtctcttt gaccggtgct gtcagcttgg cttccatgtt gactgaaatc      660

tttcttctgc aacaagctca aggtatgcct gagccaggtt ggggtagaat caccgactct      720

caccaatgga acaccttgtt gtccttgcac aacgctcaat tctacttgct gcagagaact      780

ccagaggttg ctagatccag agccacccca ttgttggact tgatcaagac tgctttgact      840

cctcacccac ctcaaaagca agcctacggt gttaccttgc ccacttctgt cttgttcatt      900

gccggtcacg atactaactt ggcaaatctc ggcggtgctt tggagttgaa ctggactctt      960

cctggtcaac ctgataacac tccaccaggt ggtgagctcg ttttcgaaag atggcgtaga     1020

ctatctgata actctcaatg gattcaggtt tcgttggtct tccaaacttt gcagcagatg     1080

agagacaaga ctccactgtc tttgaacacg cctccaggag aagtcaaatt gaccttggct     1140

ggatgtgaag agagaaatgc tcagggtatg tgttccttgg ctggtttcac tcaaatcgtt     1200

aacgaagcta gaatcccagc ttgttccttg tag                                  1233


<210>  79
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-M2

<400>  79

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Glu Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Trp Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Glu Leu Leu Pro Asn Gln Thr Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Glu Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Tyr Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Ser Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Asp Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro Asn Gly Thr Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  80
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAPA-M2-B

<400>  80

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Glu Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Cys Tyr Leu Gly His Tyr Trp Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Glu Leu Leu Pro Asn Gln Thr Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Cys Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Glu Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Tyr Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Ser Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Asp Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro Asn Gly Thr Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  81
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-M2-C

<400>  81

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Glu Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Cys Leu Gly His Tyr Trp Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Glu Leu Leu Pro Asn Gln Thr Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Glu Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Tyr Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Ser Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Asp Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro Asn Gly Thr Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Cys Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  82
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-M2-D

<400>  82

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Glu Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Cys Trp Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Glu Leu Leu Pro Asn Gln Thr Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Glu Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Tyr Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Ser Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Asp Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro Asn Gly Thr Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Cys Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  83
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-M2-M

<400>  83

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Glu Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Trp Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Glu Leu Leu Pro Asn Gln Thr Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Glu Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Tyr Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Ser Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Asp Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro Asn Gly Thr Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Cys Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Cys Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  84
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-M2-O

<400>  84

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Glu Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Trp Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Glu Leu Leu Pro Asn Gln Thr Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Glu Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Tyr Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Ser Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Asp Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro Asn Gly Thr Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Cys Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Cys Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  85
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-M2-BO

<400>  85

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Glu Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Cys Tyr Leu Gly His Tyr Trp Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Glu Leu Leu Pro Asn Gln Thr Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Cys Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Glu Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Tyr Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Ser Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Asp Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro Asn Gly Thr Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Cys Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Cys Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  86
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-M2-DO

<400>  86

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Glu Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Cys Trp Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Glu Leu Leu Pro Asn Gln Thr Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Glu Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Tyr Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Ser Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Asp Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro Asn Gly Thr Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Cys Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Cys Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Cys Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  87
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-M2-MO

<400>  87

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Glu Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Trp Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Glu Leu Leu Pro Asn Gln Thr Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Glu Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Tyr Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Ser Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Asp Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro Asn Gly Thr Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Cys Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Cys Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Cys Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Cys Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  88
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-M2-CO

<400>  88

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Ala Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Glu Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Cys Leu Gly His Tyr Trp Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Glu Leu Leu Pro Asn Gln Thr Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His Thr Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Asn Ala Asn Val Thr Asp Ala Ile 
    130                 135                 140                 


Leu Glu Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Tyr Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Ser Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Asp Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro Asn Gly Thr Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Cys Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Cys Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Cys Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  89
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-M2

<400>  89
cagtccgagc ccgagctgaa gctggagtcc gtcgtcatcg tctcccgcca cggtgtccgc       60

gcccccacca aggccaccca gctgatgcag gacgtcaccc ccgacgcctg gcccacctgg      120

cccgtcaagc tgggtgagct gaccccccgc ggtggtgagc tgatcgccta cctgggtcac      180

tactggcgcc agcgcctggt cgccgacgag ctgctgccca accagacctg cccccagtcc      240

ggtcaggtcg ccatcatcgc cgacgtcgac gagcgcaccc gcaagaccgg tgaggccttc      300

gccgccggtc tggcccccga ctgcgccatc accgtccaca cccaggccga cacctcctcc      360

cccgaccccc tgttcaaccc cctgaagacc ggtgtctgcc agctggacaa cgccaacgtc      420

accgacgcca tcctggagcg cgccggtggt tccatcgccg acttcaccgg tcactaccag      480

accgccttcc gcgagctgga gcgcgtcctg aacttctccc agtccaacct gtgcctgaag      540

cgcgagaagc aggacgagtc ctgctccctg acccaggccc tgccctccga gctgaaggtc      600

tccgccgaca acgtctccct gaccggtgcc gtctccctgg cctccatgct gaccgagatc      660

ttcctgctgc agcaggccca gggtatgccc gagcccggtt ggggtcgcat caccgactcc      720

caccagtgga acaccctgct gtccctgcac aacgcccagt tcgacctgct gcagcgcacc      780

cccgaggtcg cccgctcccg cgccaccccc ctgctggacc tgatcaagac cgccctgacc      840

cccaacggta cccagaagca ggcctacggt gtcaccctgc ccacctccgt cctgttcatc      900

gccggtcacg acaccaacct ggccaacctg ggtggtgccc tggagctgaa ctggaccctg      960

cccggtcagc ccgacaacac cccccccggt ggtgagctgg tcttcgagcg ctggcgccgc     1020

ctgtccgaca actcccagtg gatccaggtc tccctggtct tccagaccct gcagcagatg     1080

cgcgacaaga cccccctgtc cctgaacacc ccccccggtg aggtcaagct gaccctggcc     1140

ggttgcgagg agcgcaacgc ccagggtatg tgctccctgg ccggtttcac ccagatcgtc     1200

aacgaggccc gcatccccgc ctgctccctg taa                                  1233


<210>  90
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-M2-B

<400>  90
cagtccgagc ccgagctgaa gctggagtcc gtcgtcatcg tctcccgcca cggtgtccgc       60

gcccccacca aggccaccca gctgatgcag gacgtcaccc ccgacgcctg gcccacctgg      120

cccgtcaagc tgggtgagct gaccccccgc ggtggtgagc tgatctgcta cctgggtcac      180

tactggcgcc agcgcctggt cgccgacgag ctgctgccca accagacctg cccccagtcc      240

ggtcaggtcg ccatcatcgc cgacgtcgac gagcgcaccc gcaagaccgg tgaggccttc      300

gccgcctgcc tggcccccga ctgcgccatc accgtccaca cccaggccga cacctcctcc      360

cccgaccccc tgttcaaccc cctgaagacc ggtgtctgcc agctggacaa cgccaacgtc      420

accgacgcca tcctggagcg cgccggtggt tccatcgccg acttcaccgg tcactaccag      480

accgccttcc gcgagctgga gcgcgtcctg aacttctccc agtccaacct gtgcctgaag      540

cgcgagaagc aggacgagtc ctgctccctg acccaggccc tgccctccga gctgaaggtc      600

tccgccgaca acgtctccct gaccggtgcc gtctccctgg cctccatgct gaccgagatc      660

ttcctgctgc agcaggccca gggtatgccc gagcccggtt ggggtcgcat caccgactcc      720

caccagtgga acaccctgct gtccctgcac aacgcccagt tcgacctgct gcagcgcacc      780

cccgaggtcg cccgctcccg cgccaccccc ctgctggacc tgatcaagac cgccctgacc      840

cccaacggta cccagaagca ggcctacggt gtcaccctgc ccacctccgt cctgttcatc      900

gccggtcacg acaccaacct ggccaacctg ggtggtgccc tggagctgaa ctggaccctg      960

cccggtcagc ccgacaacac cccccccggt ggtgagctgg tcttcgagcg ctggcgccgc     1020

ctgtccgaca actcccagtg gatccaggtc tccctggtct tccagaccct gcagcagatg     1080

cgcgacaaga cccccctgtc cctgaacacc ccccccggtg aggtcaagct gaccctggcc     1140

ggttgcgagg agcgcaacgc ccagggtatg tgctccctgg ccggtttcac ccagatcgtc     1200

aacgaggccc gcatccccgc ctgctccctg taa                                  1233


<210>  91
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAPA-M2-C

<400>  91
cagtccgagc ccgagctgaa gctggagtcc gtcgtcatcg tctcccgcca cggtgtccgc       60

gcccccacca aggccaccca gctgatgcag gacgtcaccc ccgacgcctg gcccacctgg      120

cccgtcaagc tgggtgagct gaccccccgc ggtggtgagc tgatcgcctg cctgggtcac      180

tactggcgcc agcgcctggt cgccgacgag ctgctgccca accagacctg cccccagtcc      240

ggtcaggtcg ccatcatcgc cgacgtcgac gagcgcaccc gcaagaccgg tgaggccttc      300

gccgccggtc tggcccccga ctgcgccatc accgtccaca cccaggccga cacctcctcc      360

cccgaccccc tgttcaaccc cctgaagacc ggtgtctgcc agctggacaa cgccaacgtc      420

accgacgcca tcctggagcg cgccggtggt tccatcgccg acttcaccgg tcactaccag      480

accgccttcc gcgagctgga gcgcgtcctg aacttctccc agtccaacct gtgcctgaag      540

cgcgagaagc aggacgagtc ctgctccctg acccaggccc tgccctccga gctgaaggtc      600

tccgccgaca acgtctccct gaccggtgcc gtctccctgg cctccatgct gaccgagatc      660

ttcctgctgc agcaggccca gggtatgccc gagcccggtt ggggtcgcat caccgactcc      720

caccagtgga acaccctgct gtccctgcac aacgcccagt tcgacctgct gcagcgcacc      780

cccgaggtcg cccgctcccg cgccaccccc ctgctggacc tgatcaagac cgccctgacc      840

cccaacggta cccagaagca ggcctacggt gtcaccctgc ccacctccgt cctgttcatc      900

gccggtcacg acaccaacct ggccaacctg ggtggtgccc tggagctgaa ctggaccctg      960

cccggtcagc ccgacaacac cccccccggt ggtgagctgg tcttcgagcg ctggcgccgc     1020

ctgtccgaca actcccagtg gatccaggtc tccctggtct tccagaccct gcagcagatg     1080

cgcgacaaga ccccctgctc cctgaacacc ccccccggtg aggtcaagct gaccctggcc     1140

ggttgcgagg agcgcaacgc ccagggtatg tgctccctgg ccggtttcac ccagatcgtc     1200

aacgaggccc gcatccccgc ctgctccctg taa                                  1233


<210>  92
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAPA-M2-D

<400>  92
cagtccgagc ccgagctgaa gctggagtcc gtcgtcatcg tctcccgcca cggtgtccgc       60

gcccccacca aggccaccca gctgatgcag gacgtcaccc ccgacgcctg gcccacctgg      120

cccgtcaagc tgggtgagct gaccccccgc ggtggtgagc tgatcgccta cctgggtcac      180

tgctggcgcc agcgcctggt cgccgacgag ctgctgccca accagacctg cccccagtcc      240

ggtcaggtcg ccatcatcgc cgacgtcgac gagcgcaccc gcaagaccgg tgaggccttc      300

gccgccggtc tggcccccga ctgcgccatc accgtccaca cccaggccga cacctcctcc      360

cccgaccccc tgttcaaccc cctgaagacc ggtgtctgcc agctggacaa cgccaacgtc      420

accgacgcca tcctggagcg cgccggtggt tccatcgccg acttcaccgg tcactaccag      480

accgccttcc gcgagctgga gcgcgtcctg aacttctccc agtccaacct gtgcctgaag      540

cgcgagaagc aggacgagtc ctgctccctg acccaggccc tgccctccga gctgaaggtc      600

tccgccgaca acgtctccct gaccggtgcc gtctccctgg cctccatgct gaccgagatc      660

ttcctgctgc agcaggccca gggtatgccc gagcccggtt ggggtcgcat caccgactcc      720

caccagtgga acaccctgct gtccctgcac aacgcccagt tcgacctgct gcagcgcacc      780

cccgaggtcg cccgctcccg cgccaccccc ctgctggacc tgatcaagac cgccctgacc      840

cccaacggta cccagaagca ggcctacggt gtcaccctgc ccacctccgt cctgttcatc      900

gccggtcacg acaccaacct ggccaacctg ggtggtgccc tggagctgaa ctggaccctg      960

cccggtcagc ccgacaacac cccccccggt ggtgagctgg tcttcgagcg ctggcgccgc     1020

ctgtccgaca actcccagtg gatccaggtc tccctggtct tccagaccct gcagcagatg     1080

cgcgacaaga ccccctgctc cctgaacacc ccccccggtg aggtcaagct gaccctggcc     1140

ggttgcgagg agcgcaacgc ccagggtatg tgctccctgg ccggtttcac ccagatcgtc     1200

aacgaggccc gcatccccgc ctgctccctg taa                                  1233


<210>  93
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-M2-M

<400>  93
cagtccgagc ccgagctgaa gctggagtcc gtcgtcatcg tctcccgcca cggtgtccgc       60

gcccccacca aggccaccca gctgatgcag gacgtcaccc ccgacgcctg gcccacctgg      120

cccgtcaagc tgggtgagct gaccccccgc ggtggtgagc tgatcgccta cctgggtcac      180

tactggcgcc agcgcctggt cgccgacgag ctgctgccca accagacctg cccccagtcc      240

ggtcaggtcg ccatcatcgc cgacgtcgac gagcgcaccc gcaagaccgg tgaggccttc      300

gccgccggtc tggcccccga ctgcgccatc accgtccaca cccaggccga cacctcctcc      360

cccgaccccc tgttcaaccc cctgaagacc ggtgtctgcc agctggacaa cgccaacgtc      420

accgacgcca tcctggagcg cgccggtggt tccatcgccg acttcaccgg tcactaccag      480

accgccttcc gcgagctgga gcgcgtcctg aacttctccc agtccaacct gtgcctgaag      540

cgcgagaagc aggacgagtc ctgctccctg acccaggccc tgccctccga gctgaaggtc      600

tccgccgaca acgtctccct gaccggtgcc gtctccctgg cctccatgct gaccgagatc      660

ttcctgctgc agcaggccca gggtatgccc gagcccggtt ggggtcgcat caccgactcc      720

caccagtgga acaccctgct gtccctgcac aacgcccagt tcgacctgct gcagcgcacc      780

cccgaggtcg cccgctcccg cgccaccccc ctgctggacc tgatcaagac cgccctgacc      840

cccaacggta cccagaagca ggcctacggt gtcaccctgc ccacctccgt cctgttcatc      900

gccggtcacg acaccaacct ggccaacctg ggtggtgccc tgtgcctgaa ctggaccctg      960

cccggtcagc ccgacaacac cccccccggt ggtgagctgg tcttcgagcg ctggcgccgc     1020

ctgtccgaca actcccagtg gatccaggtc tccctggtct tccagaccct gcagcagatg     1080

cgcgacaaga cccccctgtc cctgaacacc ccccccggtg aggtcaagct gaccctgtgc     1140

ggttgcgagg agcgcaacgc ccagggtatg tgctccctgg ccggtttcac ccagatcgtc     1200

aacgaggccc gcatccccgc ctgctccctg taa                                  1233


<210>  94
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-M2-O

<400>  94
cagtccgagc ccgagctgaa gctggagtcc gtcgtcatcg tctcccgcca cggtgtccgc       60

gcccccacca aggccaccca gctgatgcag gacgtcaccc ccgacgcctg gcccacctgg      120

cccgtcaagc tgggtgagct gaccccccgc ggtggtgagc tgatctgcta cctgggtcac      180

tactggcgcc agcgcctggt cgccgacgag ctgctgccca accagacctg cccccagtcc      240

ggtcaggtcg ccatcatcgc cgacgtcgac gagcgcaccc gcaagaccgg tgaggccttc      300

gccgcctgcc tggcccccga ctgcgccatc accgtccaca cccaggccga cacctcctcc      360

cccgaccccc tgttcaaccc cctgaagacc ggtgtctgcc agctggacaa cgccaacgtc      420

accgacgcca tcctggagcg cgccggtggt tccatcgccg acttcaccgg tcactaccag      480

accgccttcc gcgagctgga gcgcgtcctg aacttctccc agtccaacct gtgcctgaag      540

cgcgagaagc aggacgagtc ctgctccctg acccaggccc tgccctccga gctgaaggtc      600

tccgccgaca acgtctccct gaccggtgcc gtctccctgg cctccatgct gaccgagatc      660

ttcctgctgc agcaggccca gggtatgccc gagcccggtt ggggtcgcat caccgactcc      720

caccagtgga acaccctgct gtccctgcac aacgcccagt tcgacctgct gcagcgcacc      780

cccgaggtcg cccgctcccg cgccaccccc ctgctggacc tgatcaagac cgccctgacc      840

cccaacggta cccagaagca ggcctacggt gtcaccctgc ccacctccgt cctgttcatc      900

gccggtcacg acaccaacct ggccaacctg ggtggtgccc tggagctgaa ctggaccctg      960

cccggtcagc ccgacaacac cccccccggt ggtgagctgg tcttcgagcg ctggcgccgc     1020

ctgtccgaca actcccagtg gatccaggtc tccctggtct tccagaccct gcagcagatg     1080

cgcgacaaga cccccctgtc cctgaacacc ccccccggtg aggtcaagct gaccctggcc     1140

ggttgcgagg agcgcaacgc ccagggtatg tgctccctgg ccggtttcac ccagatcgtc     1200

aacgaggccc gcatccccgc ctgctccctg taa                                  1233


<210>  95
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAPA-M2-BO

<400>  95
cagtccgagc ccgagctgaa gctggagtcc gtcgtcatcg tctcccgcca cggtgtccgc       60

gcccccacca aggccaccca gctgatgcag gacgtcaccc ccgacgcctg gcccacctgg      120

cccgtcaagc tgggtgagct gaccccccgc ggtggtgagc tgatctgcta cctgggtcac      180

tactggcgcc agcgcctggt cgccgacgag ctgctgccca accagacctg cccccagtcc      240

ggtcaggtcg ccatcatcgc cgacgtcgac gagcgcaccc gcaagaccgg tgaggccttc      300

gccgcctgcc tggcccccga ctgcgccatc accgtccaca cccaggccga cacctcctcc      360

cccgaccccc tgttcaaccc cctgaagacc ggtgtctgcc agctggacaa cgccaacgtc      420

accgacgcca tcctggagcg cgccggtggt tccatcgccg acttcaccgg tcactaccag      480

accgccttcc gcgagctgga gcgcgtcctg aacttctccc agtccaacct gtgcctgaag      540

cgcgagaagc aggacgagtc ctgctccctg acccaggccc tgccctccga gctgaaggtc      600

tccgccgaca acgtctccct gaccggtgcc gtctccctgg cctccatgct gaccgagatc      660

ttcctgctgc agcaggccca gggtatgccc gagcccggtt ggggtcgcat caccgactcc      720

caccagtgga acaccctgct gtccctgcac aacgcccagt tcgacctgct gcagcgcacc      780

cccgaggtcg cccgctcccg cgccaccccc ctgctggacc tgatcaagac cgccctgacc      840

cccaacggta cccagaagca ggcctacggt gtcaccctgc ccacctccgt cctgttcatc      900

gccggtcacg acaccaacct ggccaacctg ggtggtgccc tggagctgaa ctggaccctg      960

cccggtcagc ccgacaacac cccccccggt ggtgagctgg tcttcgagcg ctggcgccgc     1020

ctgtccgaca actcctgctg gatccaggtc tccctggtct tccagaccct gcagcagatg     1080

cgcgacaaga cccccctgtc cctgaacacc ccccccggtg aggtcaagct gaccctggcc     1140

ggttgcgagg agcgcaacgc ccagggtatg tgctcctgcg ccggtttcac ccagatcgtc     1200

aacgaggccc gcatccccgc ctgctccctg taa                                  1233


<210>  96
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-M2-DO

<400>  96
cagtccgagc ccgagctgaa gctggagtcc gtcgtcatcg tctcccgcca cggtgtccgc       60

gcccccacca aggccaccca gctgatgcag gacgtcaccc ccgacgcctg gcccacctgg      120

cccgtcaagc tgggtgagct gaccccccgc ggtggtgagc tgatcgccta cctgggtcac      180

tgctggcgcc agcgcctggt cgccgacgag ctgctgccca accagacctg cccccagtcc      240

ggtcaggtcg ccatcatcgc cgacgtcgac gagcgcaccc gcaagaccgg tgaggccttc      300

gccgccggtc tggcccccga ctgcgccatc accgtccaca cccaggccga cacctcctcc      360

cccgaccccc tgttcaaccc cctgaagacc ggtgtctgcc agctggacaa cgccaacgtc      420

accgacgcca tcctggagcg cgccggtggt tccatcgccg acttcaccgg tcactaccag      480

accgccttcc gcgagctgga gcgcgtcctg aacttctccc agtccaacct gtgcctgaag      540

cgcgagaagc aggacgagtc ctgctccctg acccaggccc tgccctccga gctgaaggtc      600

tccgccgaca acgtctccct gaccggtgcc gtctccctgg cctccatgct gaccgagatc      660

ttcctgctgc agcaggccca gggtatgccc gagcccggtt ggggtcgcat caccgactcc      720

caccagtgga acaccctgct gtccctgcac aacgcccagt tcgacctgct gcagcgcacc      780

cccgaggtcg cccgctcccg cgccaccccc ctgctggacc tgatcaagac cgccctgacc      840

cccaacggta cccagaagca ggcctacggt gtcaccctgc ccacctccgt cctgttcatc      900

gccggtcacg acaccaacct ggccaacctg ggtggtgccc tggagctgaa ctggaccctg      960

cccggtcagc ccgacaacac cccccccggt ggtgagctgg tcttcgagcg ctggcgccgc     1020

ctgtccgaca actcctgctg gatccaggtc tccctggtct tccagaccct gcagcagatg     1080

cgcgacaaga ccccctgctc cctgaacacc ccccccggtg aggtcaagct gaccctggcc     1140

ggttgcgagg agcgcaacgc ccagggtatg tgctcctgcg ccggtttcac ccagatcgtc     1200

aacgaggccc gcatccccgc ctgctccctg taa                                  1233


<210>  97
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-M2-MO

<400>  97
cagtccgagc ccgagctgaa gctggagtcc gtcgtcatcg tctcccgcca cggtgtccgc       60

gcccccacca aggccaccca gctgatgcag gacgtcaccc ccgacgcctg gcccacctgg      120

cccgtcaagc tgggtgagct gaccccccgc ggtggtgagc tgatcgccta cctgggtcac      180

tactggcgcc agcgcctggt cgccgacgag ctgctgccca accagacctg cccccagtcc      240

ggtcaggtcg ccatcatcgc cgacgtcgac gagcgcaccc gcaagaccgg tgaggccttc      300

gccgccggtc tggcccccga ctgcgccatc accgtccaca cccaggccga cacctcctcc      360

cccgaccccc tgttcaaccc cctgaagacc ggtgtctgcc agctggacaa cgccaacgtc      420

accgacgcca tcctggagcg cgccggtggt tccatcgccg acttcaccgg tcactaccag      480

accgccttcc gcgagctgga gcgcgtcctg aacttctccc agtccaacct gtgcctgaag      540

cgcgagaagc aggacgagtc ctgctccctg acccaggccc tgccctccga gctgaaggtc      600

tccgccgaca acgtctccct gaccggtgcc gtctccctgg cctccatgct gaccgagatc      660

ttcctgctgc agcaggccca gggtatgccc gagcccggtt ggggtcgcat caccgactcc      720

caccagtgga acaccctgct gtccctgcac aacgcccagt tcgacctgct gcagcgcacc      780

cccgaggtcg cccgctcccg cgccaccccc ctgctggacc tgatcaagac cgccctgacc      840

cccaacggta cccagaagca ggcctacggt gtcaccctgc ccacctccgt cctgttcatc      900

gccggtcacg acaccaacct ggccaacctg ggtggtgccc tgtgcctgaa ctggaccctg      960

cccggtcagc ccgacaacac cccccccggt ggtgagctgg tcttcgagcg ctggcgccgc     1020

ctgtccgaca actcctgctg gatccaggtc tccctggtct tccagaccct gcagcagatg     1080

cgcgacaaga cccccctgtc cctgaacacc ccccccggtg aggtcaagct gaccctgtgc     1140

ggttgcgagg agcgcaacgc ccagggtatg tgctcctgcg ccggtttcac ccagatcgtc     1200

aacgaggccc gcatccccgc ctgctccctg taa                                  1233


<210>  98
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAPA-M2-CO

<400>  98
cagtccgagc ccgagctgaa gctggagtcc gtcgtcatcg tctcccgcca cggtgtccgc       60

gcccccacca aggccaccca gctgatgcag gacgtcaccc ccgacgcctg gcccacctgg      120

cccgtcaagc tgggtgagct gaccccccgc ggtggtgagc tgatcgcctg cctgggtcac      180

tactggcgcc agcgcctggt cgccgacgag ctgctgccca accagacctg cccccagtcc      240

ggtcaggtcg ccatcatcgc cgacgtcgac gagcgcaccc gcaagaccgg tgaggccttc      300

gccgccggtc tggcccccga ctgcgccatc accgtccaca cccaggccga cacctcctcc      360

cccgaccccc tgttcaaccc cctgaagacc ggtgtctgcc agctggacaa cgccaacgtc      420

accgacgcca tcctggagcg cgccggtggt tccatcgccg acttcaccgg tcactaccag      480

accgccttcc gcgagctgga gcgcgtcctg aacttctccc agtccaacct gtgcctgaag      540

cgcgagaagc aggacgagtc ctgctccctg acccaggccc tgccctccga gctgaaggtc      600

tccgccgaca acgtctccct gaccggtgcc gtctccctgg cctccatgct gaccgagatc      660

ttcctgctgc agcaggccca gggtatgccc gagcccggtt ggggtcgcat caccgactcc      720

caccagtgga acaccctgct gtccctgcac aacgcccagt tcgacctgct gcagcgcacc      780

cccgaggtcg cccgctcccg cgccaccccc ctgctggacc tgatcaagac cgccctgacc      840

cccaacggta cccagaagca ggcctacggt gtcaccctgc ccacctccgt cctgttcatc      900

gccggtcacg acaccaacct ggccaacctg ggtggtgccc tggagctgaa ctggaccctg      960

cccggtcagc ccgacaacac cccccccggt ggtgagctgg tcttcgagcg ctggcgccgc     1020

ctgtccgaca actcctgctg gatccaggtc tccctggtct tccagaccct gcagcagatg     1080

cgcgacaaga ccccctgctc cctgaacacc ccccccggtg aggtcaagct gaccctggcc     1140

ggttgcgagg agcgcaacgc ccagggtatg tgctcctgcg ccggtttcac ccagatcgtc     1200

aacgaggccc gcatccccgc ctgctccctg taa                                  1233


<210>  99
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-M3

<400>  99

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Phe Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Glu Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Trp Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Glu Leu Leu Pro Asn Gln Thr Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His His Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Val Ala Asn Val Thr Arg Ala Ile 
    130                 135                 140                 


Leu Glu Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Tyr Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Ser Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Asp Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro Asn Gly Thr Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  100
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-M3-B

<400>  100

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Phe Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Glu Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Cys Tyr Leu Gly His Tyr Trp Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Glu Leu Leu Pro Asn Gln Thr Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Cys Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His His Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Val Ala Asn Val Thr Arg Ala Ile 
    130                 135                 140                 


Leu Glu Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Tyr Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Ser Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Asp Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro Asn Gly Thr Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  101
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-M3-D

<400>  101

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Phe Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Glu Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Cys Trp Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Glu Leu Leu Pro Asn Gln Thr Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His His Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Val Ala Asn Val Thr Arg Ala Ile 
    130                 135                 140                 


Leu Glu Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Tyr Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Ser Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Asp Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro Asn Gly Thr Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Cys Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  102
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-M3-M

<400>  102

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Phe Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Glu Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Trp Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Glu Leu Leu Pro Asn Gln Thr Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His His Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Val Ala Asn Val Thr Arg Ala Ile 
    130                 135                 140                 


Leu Glu Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Tyr Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Ser Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Asp Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro Asn Gly Thr Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Cys Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Cys Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  103
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   APPA-M3-O

<400>  103

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Phe Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Glu Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Trp Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Glu Leu Leu Pro Asn Gln Thr Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His His Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Val Ala Asn Val Thr Arg Ala Ile 
    130                 135                 140                 


Leu Glu Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Tyr Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Ser Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Asp Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro Asn Gly Thr Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Cys Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Cys Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  104
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-M3-C

<400>  104

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Phe Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Glu Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Cys Leu Gly His Tyr Trp Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Glu Leu Leu Pro Asn Gln Thr Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His His Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Val Ala Asn Val Thr Arg Ala Ile 
    130                 135                 140                 


Leu Glu Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Tyr Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Ser Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Asp Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro Asn Gly Thr Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Gln Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Cys Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Leu Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  105
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   APPA-M3-BO

<400>  105

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Phe Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Glu Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Cys Tyr Leu Gly His Tyr Trp Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Glu Leu Leu Pro Asn Gln Thr Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Cys Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His His Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Val Ala Asn Val Thr Arg Ala Ile 
    130                 135                 140                 


Leu Glu Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Tyr Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Ser Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Asp Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro Asn Gly Thr Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Cys Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Cys Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  106
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-M3-DO

<400>  106

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Phe Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Glu Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Cys Trp Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Glu Leu Leu Pro Asn Gln Thr Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His His Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Val Ala Asn Val Thr Arg Ala Ile 
    130                 135                 140                 


Leu Glu Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Tyr Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Ser Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Asp Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro Asn Gly Thr Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Cys Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Cys Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Cys Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  107
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-M3-MO

<400>  107

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Phe Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Glu Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Tyr Leu Gly His Tyr Trp Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Glu Leu Leu Pro Asn Gln Thr Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His His Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Val Ala Asn Val Thr Arg Ala Ile 
    130                 135                 140                 


Leu Glu Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Tyr Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Ser Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Asp Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro Asn Gly Thr Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Cys Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Cys Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Leu Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Cys Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Cys Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  108
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APPA-M3-CO

<400>  108

Gln Ser Glu Pro Glu Leu Lys Leu Glu Ser Val Val Ile Val Ser Arg 
1               5                   10                  15      


His Gly Val Arg Ala Pro Thr Lys Phe Thr Gln Leu Met Gln Asp Val 
            20                  25                  30          


Thr Pro Asp Ala Trp Pro Thr Trp Pro Val Lys Leu Gly Glu Leu Thr 
        35                  40                  45              


Pro Arg Gly Gly Glu Leu Ile Ala Cys Leu Gly His Tyr Trp Arg Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Glu Leu Leu Pro Asn Gln Thr Cys Pro Gln Ser 
65                  70                  75                  80  


Gly Gln Val Ala Ile Ile Ala Asp Val Asp Glu Arg Thr Arg Lys Thr 
                85                  90                  95      


Gly Glu Ala Phe Ala Ala Gly Leu Ala Pro Asp Cys Ala Ile Thr Val 
            100                 105                 110         


His His Gln Ala Asp Thr Ser Ser Pro Asp Pro Leu Phe Asn Pro Leu 
        115                 120                 125             


Lys Thr Gly Val Cys Gln Leu Asp Val Ala Asn Val Thr Arg Ala Ile 
    130                 135                 140                 


Leu Glu Arg Ala Gly Gly Ser Ile Ala Asp Phe Thr Gly His Tyr Gln 
145                 150                 155                 160 


Thr Ala Phe Arg Glu Leu Glu Arg Val Leu Asn Phe Ser Gln Ser Asn 
                165                 170                 175     


Leu Cys Leu Lys Arg Glu Lys Gln Asp Glu Ser Cys Ser Leu Thr Gln 
            180                 185                 190         


Ala Leu Pro Ser Glu Leu Lys Val Ser Ala Asp Asn Val Ser Leu Thr 
        195                 200                 205             


Gly Ala Val Ser Leu Ala Ser Met Leu Thr Glu Ile Phe Leu Leu Gln 
    210                 215                 220                 


Gln Ala Gln Gly Met Pro Glu Pro Gly Trp Gly Arg Ile Thr Asp Ser 
225                 230                 235                 240 


His Gln Trp Asn Thr Leu Leu Ser Leu His Asn Ala Gln Phe Asp Leu 
                245                 250                 255     


Leu Gln Arg Thr Pro Glu Val Ala Arg Ser Arg Ala Thr Pro Leu Leu 
            260                 265                 270         


Asp Leu Ile Lys Thr Ala Leu Thr Pro Asn Gly Thr Gln Lys Gln Ala 
        275                 280                 285             


Tyr Gly Val Thr Leu Pro Thr Ser Val Leu Phe Ile Ala Gly His Asp 
    290                 295                 300                 


Thr Asn Leu Ala Asn Leu Gly Gly Ala Leu Glu Leu Asn Trp Thr Leu 
305                 310                 315                 320 


Pro Gly Gln Pro Asp Asn Thr Pro Pro Gly Gly Glu Leu Val Phe Glu 
                325                 330                 335     


Arg Trp Arg Arg Leu Ser Asp Asn Ser Cys Trp Ile Gln Val Ser Leu 
            340                 345                 350         


Val Phe Gln Thr Leu Gln Gln Met Arg Asp Lys Thr Pro Cys Ser Leu 
        355                 360                 365             


Asn Thr Pro Pro Gly Glu Val Lys Leu Thr Leu Ala Gly Cys Glu Glu 
    370                 375                 380                 


Arg Asn Ala Gln Gly Met Cys Ser Cys Ala Gly Phe Thr Gln Ile Val 
385                 390                 395                 400 


Asn Glu Ala Arg Ile Pro Ala Cys Ser Leu 
                405                 410 


<210>  109
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-M3

<400>  109
cagtccgagc ccgagctcaa gctcgagtcc gtcgtcatcg tctcccgcca cggtgtccgc       60

gcccccacca agttcaccca gctcatgcag gacgtcaccc ccgacgcctg gcccacctgg      120

cccgtcaagc tcggtgagct caccccccgc ggtggtgagc tcatcgccta cctcggtcac      180

tactggcgcc agcgcctcgt cgccgacgag ctcctcccca accagacctg cccccagtcc      240

ggtcaggtcg ccatcatcgc cgacgtcgac gagcgcaccc gcaagaccgg tgaggccttc      300

gccgccggtc tcgcccccga ctgcgccatc accgtccacc accaggccga cacctcctcc      360

cccgaccccc tcttcaaccc cctcaagacc ggtgtctgcc agctcgacgt cgccaacgtc      420

acccgcgcca tcctcgagcg cgccggtggt tccatcgccg acttcaccgg tcactaccag      480

accgccttcc gcgagctcga gcgcgtcctc aacttctccc agtccaacct ctgcctcaag      540

cgcgagaagc aggacgagtc ctgctccctc acccaggccc tcccctccga gctcaaggtc      600

tccgccgaca acgtctccct caccggtgcc gtctccctcg cctccatgct caccgagatc      660

ttcctcctcc agcaggccca gggtatgccc gagcccggtt ggggtcgcat caccgactcc      720

caccagtgga acaccctcct ctccctccac aacgcccagt tcgacctcct ccagcgcacc      780

cccgaggtcg cccgctcccg cgccaccccc ctcctcgacc tcatcaagac cgccctcacc      840

cccaacggta cccagaagca ggcctacggt gtcaccctcc ccacctccgt cctcttcatc      900

gccggtcacg acaccaacct cgccaacctc ggtggtgccc tcgagctcaa ctggaccctc      960

cccggtcagc ccgacaacac cccccccggt ggtgagctcg tcttcgagcg ctggcgccgc     1020

ctctccgaca actcccagtg gatccaggtc tccctcgtct tccagaccct ccagcagatg     1080

cgcgacaaga cccccctctc cctcaacacc ccccccggtg aggtcaagct caccctcgcc     1140

ggttgcgagg agcgcaacgc ccagggtatg tgctccctcg ccggtttcac ccagatcgtc     1200

aacgaggccc gcatccccgc ctgctccctc taa                                  1233


<210>  110
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-M3-B

<400>  110
cagtccgagc ccgagctcaa gctcgagtcc gtcgtcatcg tctcccgcca cggtgtccgc       60

gcccccacca agttcaccca gctcatgcag gacgtcaccc ccgacgcctg gcccacctgg      120

cccgtcaagc tcggtgagct caccccccgc ggtggtgagc tcatctgcta cctcggtcac      180

tactggcgcc agcgcctcgt cgccgacgag ctcctcccca accagacctg cccccagtcc      240

ggtcaggtcg ccatcatcgc cgacgtcgac gagcgcaccc gcaagaccgg tgaggccttc      300

gccgcctgcc tcgcccccga ctgcgccatc accgtccacc accaggccga cacctcctcc      360

cccgaccccc tcttcaaccc cctcaagacc ggtgtctgcc agctcgacgt cgccaacgtc      420

acccgcgcca tcctcgagcg cgccggtggt tccatcgccg acttcaccgg tcactaccag      480

accgccttcc gcgagctcga gcgcgtcctc aacttctccc agtccaacct ctgcctcaag      540

cgcgagaagc aggacgagtc ctgctccctc acccaggccc tcccctccga gctcaaggtc      600

tccgccgaca acgtctccct caccggtgcc gtctccctcg cctccatgct caccgagatc      660

ttcctcctcc agcaggccca gggtatgccc gagcccggtt ggggtcgcat caccgactcc      720

caccagtgga acaccctcct ctccctccac aacgcccagt tcgacctcct ccagcgcacc      780

cccgaggtcg cccgctcccg cgccaccccc ctcctcgacc tcatcaagac cgccctcacc      840

cccaacggta cccagaagca ggcctacggt gtcaccctcc ccacctccgt cctcttcatc      900

gccggtcacg acaccaacct cgccaacctc ggtggtgccc tcgagctcaa ctggaccctc      960

cccggtcagc ccgacaacac cccccccggt ggtgagctcg tcttcgagcg ctggcgccgc     1020

ctctccgaca actcccagtg gatccaggtc tccctcgtct tccagaccct ccagcagatg     1080

cgcgacaaga cccccctctc cctcaacacc ccccccggtg aggtcaagct caccctcgcc     1140

ggttgcgagg agcgcaacgc ccagggtatg tgctccctcg ccggtttcac ccagatcgtc     1200

aacgaggccc gcatccccgc ctgctccctc taa                                  1233


<210>  111
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-M3-D

<400>  111
cagtccgagc ccgagctcaa gctcgagtcc gtcgtcatcg tctcccgcca cggtgtccgc       60

gcccccacca agttcaccca gctcatgcag gacgtcaccc ccgacgcctg gcccacctgg      120

cccgtcaagc tcggtgagct caccccccgc ggtggtgagc tcatcgccta cctcggtcac      180

tgctggcgcc agcgcctcgt cgccgacgag ctcctcccca accagacctg cccccagtcc      240

ggtcaggtcg ccatcatcgc cgacgtcgac gagcgcaccc gcaagaccgg tgaggccttc      300

gccgccggtc tcgcccccga ctgcgccatc accgtccacc accaggccga cacctcctcc      360

cccgaccccc tcttcaaccc cctcaagacc ggtgtctgcc agctcgacgt cgccaacgtc      420

acccgcgcca tcctcgagcg cgccggtggt tccatcgccg acttcaccgg tcactaccag      480

accgccttcc gcgagctcga gcgcgtcctc aacttctccc agtccaacct ctgcctcaag      540

cgcgagaagc aggacgagtc ctgctccctc acccaggccc tcccctccga gctcaaggtc      600

tccgccgaca acgtctccct caccggtgcc gtctccctcg cctccatgct caccgagatc      660

ttcctcctcc agcaggccca gggtatgccc gagcccggtt ggggtcgcat caccgactcc      720

caccagtgga acaccctcct ctccctccac aacgcccagt tcgacctcct ccagcgcacc      780

cccgaggtcg cccgctcccg cgccaccccc ctcctcgacc tcatcaagac cgccctcacc      840

cccaacggta cccagaagca ggcctacggt gtcaccctcc ccacctccgt cctcttcatc      900

gccggtcacg acaccaacct cgccaacctc ggtggtgccc tcgagctcaa ctggaccctc      960

cccggtcagc ccgacaacac cccccccggt ggtgagctcg tcttcgagcg ctggcgccgc     1020

ctctccgaca actcccagtg gatccaggtc tccctcgtct tccagaccct ccagcagatg     1080

cgcgacaaga ccccctgctc cctcaacacc ccccccggtg aggtcaagct caccctcgcc     1140

ggttgcgagg agcgcaacgc ccagggtatg tgctccctcg ccggtttcac ccagatcgtc     1200

aacgaggccc gcatccccgc ctgctccctc taa                                  1233


<210>  112
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   APPA-M3-M

<400>  112
cagtccgagc ccgagctcaa gctcgagtcc gtcgtcatcg tctcccgcca cggtgtccgc       60

gcccccacca agttcaccca gctcatgcag gacgtcaccc ccgacgcctg gcccacctgg      120

cccgtcaagc tcggtgagct caccccccgc ggtggtgagc tcatcgccta cctcggtcac      180

tactggcgcc agcgcctcgt cgccgacgag ctcctcccca accagacctg cccccagtcc      240

ggtcaggtcg ccatcatcgc cgacgtcgac gagcgcaccc gcaagaccgg tgaggccttc      300

gccgccggtc tcgcccccga ctgcgccatc accgtccacc accaggccga cacctcctcc      360

cccgaccccc tcttcaaccc cctcaagacc ggtgtctgcc agctcgacgt cgccaacgtc      420

acccgcgcca tcctcgagcg cgccggtggt tccatcgccg acttcaccgg tcactaccag      480

accgccttcc gcgagctcga gcgcgtcctc aacttctccc agtccaacct ctgcctcaag      540

cgcgagaagc aggacgagtc ctgctccctc acccaggccc tcccctccga gctcaaggtc      600

tccgccgaca acgtctccct caccggtgcc gtctccctcg cctccatgct caccgagatc      660

ttcctcctcc agcaggccca gggtatgccc gagcccggtt ggggtcgcat caccgactcc      720

caccagtgga acaccctcct ctccctccac aacgcccagt tcgacctcct ccagcgcacc      780

cccgaggtcg cccgctcccg cgccaccccc ctcctcgacc tcatcaagac cgccctcacc      840

cccaacggta cccagaagca ggcctacggt gtcaccctcc ccacctccgt cctcttcatc      900

gccggtcacg acaccaacct cgccaacctc ggtggtgccc tctgcctcaa ctggaccctc      960

cccggtcagc ccgacaacac cccccccggt ggtgagctcg tcttcgagcg ctggcgccgc     1020

ctctccgaca actcccagtg gatccaggtc tccctcgtct tccagaccct ccagcagatg     1080

cgcgacaaga cccccctctc cctcaacacc ccccccggtg aggtcaagct caccctctgc     1140

ggttgcgagg agcgcaacgc ccagggtatg tgctccctcg ccggtttcac ccagatcgtc     1200

aacgaggccc gcatccccgc ctgctccctc taa                                  1233


<210>  113
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-M3-O

<400>  113
cagtccgagc ccgagctcaa gctcgagtcc gtcgtcatcg tctcccgcca cggtgtccgc       60

gcccccacca agttcaccca gctcatgcag gacgtcaccc ccgacgcctg gcccacctgg      120

cccgtcaagc tcggtgagct caccccccgc ggtggtgagc tcatcgccta cctcggtcac      180

tactggcgcc agcgcctcgt cgccgacgag ctcctcccca accagacctg cccccagtcc      240

ggtcaggtcg ccatcatcgc cgacgtcgac gagcgcaccc gcaagaccgg tgaggccttc      300

gccgccggtc tcgcccccga ctgcgccatc accgtccacc accaggccga cacctcctcc      360

cccgaccccc tcttcaaccc cctcaagacc ggtgtctgcc agctcgacgt cgccaacgtc      420

acccgcgcca tcctcgagcg cgccggtggt tccatcgccg acttcaccgg tcactaccag      480

accgccttcc gcgagctcga gcgcgtcctc aacttctccc agtccaacct ctgcctcaag      540

cgcgagaagc aggacgagtc ctgctccctc acccaggccc tcccctccga gctcaaggtc      600

tccgccgaca acgtctccct caccggtgcc gtctccctcg cctccatgct caccgagatc      660

ttcctcctcc agcaggccca gggtatgccc gagcccggtt ggggtcgcat caccgactcc      720

caccagtgga acaccctcct ctccctccac aacgcccagt tcgacctcct ccagcgcacc      780

cccgaggtcg cccgctcccg cgccaccccc ctcctcgacc tcatcaagac cgccctcacc      840

cccaacggta cccagaagca ggcctacggt gtcaccctcc ccacctccgt cctcttcatc      900

gccggtcacg acaccaacct cgccaacctc ggtggtgccc tcgagctcaa ctggaccctc      960

cccggtcagc ccgacaacac cccccccggt ggtgagctcg tcttcgagcg ctggcgccgc     1020

ctctccgaca actcctgctg gatccaggtc tccctcgtct tccagaccct ccagcagatg     1080

cgcgacaaga cccccctctc cctcaacacc ccccccggtg aggtcaagct caccctcgcc     1140

ggttgcgagg agcgcaacgc ccagggtatg tgctcctgcg ccggtttcac ccagatcgtc     1200

aacgaggccc gcatccccgc ctgctccctc taa                                  1233


<210>  114
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-M3-C

<400>  114
cagtccgagc ccgagctcaa gctcgagtcc gtcgtcatcg tctcccgcca cggtgtccgc       60

gcccccacca agttcaccca gctcatgcag gacgtcaccc ccgacgcctg gcccacctgg      120

cccgtcaagc tcggtgagct caccccccgc ggtggtgagc tcatcgcctg cctcggtcac      180

tactggcgcc agcgcctcgt cgccgacgag ctcctcccca accagacctg cccccagtcc      240

ggtcaggtcg ccatcatcgc cgacgtcgac gagcgcaccc gcaagaccgg tgaggccttc      300

gccgccggtc tcgcccccga ctgcgccatc accgtccacc accaggccga cacctcctcc      360

cccgaccccc tcttcaaccc cctcaagacc ggtgtctgcc agctcgacgt cgccaacgtc      420

acccgcgcca tcctcgagcg cgccggtggt tccatcgccg acttcaccgg tcactaccag      480

accgccttcc gcgagctcga gcgcgtcctc aacttctccc agtccaacct ctgcctcaag      540

cgcgagaagc aggacgagtc ctgctccctc acccaggccc tcccctccga gctcaaggtc      600

tccgccgaca acgtctccct caccggtgcc gtctccctcg cctccatgct caccgagatc      660

ttcctcctcc agcaggccca gggtatgccc gagcccggtt ggggtcgcat caccgactcc      720

caccagtgga acaccctcct ctccctccac aacgcccagt tcgacctcct ccagcgcacc      780

cccgaggtcg cccgctcccg cgccaccccc ctcctcgacc tcatcaagac cgccctcacc      840

cccaacggta cccagaagca ggcctacggt gtcaccctcc ccacctccgt cctcttcatc      900

gccggtcacg acaccaacct cgccaacctc ggtggtgccc tcgagctcaa ctggaccctc      960

cccggtcagc ccgacaacac cccccccggt ggtgagctcg tcttcgagcg ctggcgccgc     1020

ctctccgaca actcccagtg gatccaggtc tccctcgtct tccagaccct ccagcagatg     1080

cgcgacaaga ccccctgctc cctcaacacc ccccccggtg aggtcaagct caccctcgcc     1140

ggttgcgagg agcgcaacgc ccagggtatg tgctccctcg ccggtttcac ccagatcgtc     1200

aacgaggccc gcatccccgc ctgctccctc taa                                  1233


<210>  115
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-M3-BO

<400>  115
cagtccgagc ccgagctcaa gctcgagtcc gtcgtcatcg tctcccgcca cggtgtccgc       60

gcccccacca agttcaccca gctcatgcag gacgtcaccc ccgacgcctg gcccacctgg      120

cccgtcaagc tcggtgagct caccccccgc ggtggtgagc tcatctgcta cctcggtcac      180

tactggcgcc agcgcctcgt cgccgacgag ctcctcccca accagacctg cccccagtcc      240

ggtcaggtcg ccatcatcgc cgacgtcgac gagcgcaccc gcaagaccgg tgaggccttc      300

gccgcctgcc tcgcccccga ctgcgccatc accgtccacc accaggccga cacctcctcc      360

cccgaccccc tcttcaaccc cctcaagacc ggtgtctgcc agctcgacgt cgccaacgtc      420

acccgcgcca tcctcgagcg cgccggtggt tccatcgccg acttcaccgg tcactaccag      480

accgccttcc gcgagctcga gcgcgtcctc aacttctccc agtccaacct ctgcctcaag      540

cgcgagaagc aggacgagtc ctgctccctc acccaggccc tcccctccga gctcaaggtc      600

tccgccgaca acgtctccct caccggtgcc gtctccctcg cctccatgct caccgagatc      660

ttcctcctcc agcaggccca gggtatgccc gagcccggtt ggggtcgcat caccgactcc      720

caccagtgga acaccctcct ctccctccac aacgcccagt tcgacctcct ccagcgcacc      780

cccgaggtcg cccgctcccg cgccaccccc ctcctcgacc tcatcaagac cgccctcacc      840

cccaacggta cccagaagca ggcctacggt gtcaccctcc ccacctccgt cctcttcatc      900

gccggtcacg acaccaacct cgccaacctc ggtggtgccc tcgagctcaa ctggaccctc      960

cccggtcagc ccgacaacac cccccccggt ggtgagctcg tcttcgagcg ctggcgccgc     1020

ctctccgaca actcctgctg gatccaggtc tccctcgtct tccagaccct ccagcagatg     1080

cgcgacaaga cccccctctc cctcaacacc ccccccggtg aggtcaagct caccctcgcc     1140

ggttgcgagg agcgcaacgc ccagggtatg tgctcctgcg ccggtttcac ccagatcgtc     1200

aacgaggccc gcatccccgc ctgctccctc taa                                  1233


<210>  116
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-M3-DO

<400>  116
cagtccgagc ccgagctcaa gctcgagtcc gtcgtcatcg tctcccgcca cggtgtccgc       60

gcccccacca agttcaccca gctcatgcag gacgtcaccc ccgacgcctg gcccacctgg      120

cccgtcaagc tcggtgagct caccccccgc ggtggtgagc tcatcgccta cctcggtcac      180

tgctggcgcc agcgcctcgt cgccgacgag ctcctcccca accagacctg cccccagtcc      240

ggtcaggtcg ccatcatcgc cgacgtcgac gagcgcaccc gcaagaccgg tgaggccttc      300

gccgccggtc tcgcccccga ctgcgccatc accgtccacc accaggccga cacctcctcc      360

cccgaccccc tcttcaaccc cctcaagacc ggtgtctgcc agctcgacgt cgccaacgtc      420

acccgcgcca tcctcgagcg cgccggtggt tccatcgccg acttcaccgg tcactaccag      480

accgccttcc gcgagctcga gcgcgtcctc aacttctccc agtccaacct ctgcctcaag      540

cgcgagaagc aggacgagtc ctgctccctc acccaggccc tcccctccga gctcaaggtc      600

tccgccgaca acgtctccct caccggtgcc gtctccctcg cctccatgct caccgagatc      660

ttcctcctcc agcaggccca gggtatgccc gagcccggtt ggggtcgcat caccgactcc      720

caccagtgga acaccctcct ctccctccac aacgcccagt tcgacctcct ccagcgcacc      780

cccgaggtcg cccgctcccg cgccaccccc ctcctcgacc tcatcaagac cgccctcacc      840

cccaacggta cccagaagca ggcctacggt gtcaccctcc ccacctccgt cctcttcatc      900

gccggtcacg acaccaacct cgccaacctc ggtggtgccc tcgagctcaa ctggaccctc      960

cccggtcagc ccgacaacac cccccccggt ggtgagctcg tcttcgagcg ctggcgccgc     1020

ctctccgaca actcctgctg gatccaggtc tccctcgtct tccagaccct ccagcagatg     1080

cgcgacaaga ccccctgctc cctcaacacc ccccccggtg aggtcaagct caccctcgcc     1140

ggttgcgagg agcgcaacgc ccagggtatg tgctcctgcg ccggtttcac ccagatcgtc     1200

aacgaggccc gcatccccgc ctgctccctc taa                                  1233


<210>  117
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-M3-MO

<400>  117
cagtccgagc ccgagctcaa gctcgagtcc gtcgtcatcg tctcccgcca cggtgtccgc       60

gcccccacca agttcaccca gctcatgcag gacgtcaccc ccgacgcctg gcccacctgg      120

cccgtcaagc tcggtgagct caccccccgc ggtggtgagc tcatcgccta cctcggtcac      180

tactggcgcc agcgcctcgt cgccgacgag ctcctcccca accagacctg cccccagtcc      240

ggtcaggtcg ccatcatcgc cgacgtcgac gagcgcaccc gcaagaccgg tgaggccttc      300

gccgccggtc tcgcccccga ctgcgccatc accgtccacc accaggccga cacctcctcc      360

cccgaccccc tcttcaaccc cctcaagacc ggtgtctgcc agctcgacgt cgccaacgtc      420

acccgcgcca tcctcgagcg cgccggtggt tccatcgccg acttcaccgg tcactaccag      480

accgccttcc gcgagctcga gcgcgtcctc aacttctccc agtccaacct ctgcctcaag      540

cgcgagaagc aggacgagtc ctgctccctc acccaggccc tcccctccga gctcaaggtc      600

tccgccgaca acgtctccct caccggtgcc gtctccctcg cctccatgct caccgagatc      660

ttcctcctcc agcaggccca gggtatgccc gagcccggtt ggggtcgcat caccgactcc      720

caccagtgga acaccctcct ctccctccac aacgcccagt tcgacctcct ccagcgcacc      780

cccgaggtcg cccgctcccg cgccaccccc ctcctcgacc tcatcaagac cgccctcacc      840

cccaacggta cccagaagca ggcctacggt gtcaccctcc ccacctccgt cctcttcatc      900

gccggtcacg acaccaacct cgccaacctc ggtggtgccc tctgcctcaa ctggaccctc      960

cccggtcagc ccgacaacac cccccccggt ggtgagctcg tcttcgagcg ctggcgccgc     1020

ctctccgaca actcctgctg gatccaggtc tccctcgtct tccagaccct ccagcagatg     1080

cgcgacaaga cccccctctc cctcaacacc ccccccggtg aggtcaagct caccctctgc     1140

ggttgcgagg agcgcaacgc ccagggtatg tgctcctgcg ccggtttcac ccagatcgtc     1200

aacgaggccc gcatccccgc ctgctccctc taa                                  1233


<210>  118
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APPA-M3-CO

<400>  118
cagtccgagc ccgagctcaa gctcgagtcc gtcgtcatcg tctcccgcca cggtgtccgc       60

gcccccacca agttcaccca gctcatgcag gacgtcaccc ccgacgcctg gcccacctgg      120

cccgtcaagc tcggtgagct caccccccgc ggtggtgagc tcatcgcctg cctcggtcac      180

tactggcgcc agcgcctcgt cgccgacgag ctcctcccca accagacctg cccccagtcc      240

ggtcaggtcg ccatcatcgc cgacgtcgac gagcgcaccc gcaagaccgg tgaggccttc      300

gccgccggtc tcgcccccga ctgcgccatc accgtccacc accaggccga cacctcctcc      360

cccgaccccc tcttcaaccc cctcaagacc ggtgtctgcc agctcgacgt cgccaacgtc      420

acccgcgcca tcctcgagcg cgccggtggt tccatcgccg acttcaccgg tcactaccag      480

accgccttcc gcgagctcga gcgcgtcctc aacttctccc agtccaacct ctgcctcaag      540

cgcgagaagc aggacgagtc ctgctccctc acccaggccc tcccctccga gctcaaggtc      600

tccgccgaca acgtctccct caccggtgcc gtctccctcg cctccatgct caccgagatc      660

ttcctcctcc agcaggccca gggtatgccc gagcccggtt ggggtcgcat caccgactcc      720

caccagtgga acaccctcct ctccctccac aacgcccagt tcgacctcct ccagcgcacc      780

cccgaggtcg cccgctcccg cgccaccccc ctcctcgacc tcatcaagac cgccctcacc      840

cccaacggta cccagaagca ggcctacggt gtcaccctcc ccacctccgt cctcttcatc      900

gccggtcacg acaccaacct cgccaacctc ggtggtgccc tcgagctcaa ctggaccctc      960

cccggtcagc ccgacaacac cccccccggt ggtgagctcg tcttcgagcg ctggcgccgc     1020

ctctccgaca actcctgctg gatccaggtc tccctcgtct tccagaccct ccagcagatg     1080

cgcgacaaga ccccctgctc cctcaacacc ccccccggtg aggtcaagct caccctcgcc     1140

ggttgcgagg agcgcaacgc ccagggtatg tgctcctgcg ccggtttcac ccagatcgtc     1200

aacgaggccc gcatccccgc ctgctccctc taa                                  1233


