                         SEQUENCE LISTING

<110>  ABBVIE STEMCENTRX LLC
 
<120>  ANTI-SEZ6 ANTIBODY DRUG CONJUGATES AND METHODS OF USE

<130>  381493-703WO(167862)

<150>  62/678,061
<151>  2018-05-30

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  994
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Pro Val Ala Leu Leu Leu Leu Pro Ser Leu Leu Ala Leu Leu 
1               5                   10                  15      


Ala His Gly Leu Ser Leu Glu Ala Pro Thr Val Gly Lys Gly Gln Ala 
            20                  25                  30          


Pro Gly Ile Glu Glu Thr Asp Gly Glu Leu Thr Ala Ala Pro Thr Pro 
        35                  40                  45              


Glu Gln Pro Glu Arg Gly Val His Phe Val Thr Thr Ala Pro Thr Leu 
    50                  55                  60                  


Lys Leu Leu Asn His His Pro Leu Leu Glu Glu Phe Leu Gln Glu Gly 
65                  70                  75                  80  


Leu Glu Lys Gly Asp Glu Glu Leu Arg Pro Ala Leu Pro Phe Gln Pro 
                85                  90                  95      


Asp Pro Pro Ala Pro Phe Thr Pro Ser Pro Leu Pro Arg Leu Ala Asn 
            100                 105                 110         


Gln Asp Ser Arg Pro Val Phe Thr Ser Pro Thr Pro Ala Met Ala Ala 
        115                 120                 125             


Val Pro Thr Gln Pro Gln Ser Lys Glu Gly Pro Trp Ser Pro Glu Ser 
    130                 135                 140                 


Glu Ser Pro Met Leu Arg Ile Thr Ala Pro Leu Pro Pro Gly Pro Ser 
145                 150                 155                 160 


Met Ala Val Pro Thr Leu Gly Pro Gly Glu Ile Ala Ser Thr Thr Pro 
                165                 170                 175     


Pro Ser Arg Ala Trp Thr Pro Thr Gln Glu Gly Pro Gly Asp Met Gly 
            180                 185                 190         


Arg Pro Trp Val Ala Glu Val Val Ser Gln Gly Ala Gly Ile Gly Ile 
        195                 200                 205             


Gln Gly Thr Ile Thr Ser Ser Thr Ala Ser Gly Asp Asp Glu Glu Thr 
    210                 215                 220                 


Thr Thr Thr Thr Thr Ile Ile Thr Thr Thr Ile Thr Thr Val Gln Thr 
225                 230                 235                 240 


Pro Gly Pro Cys Ser Trp Asn Phe Ser Gly Pro Glu Gly Ser Leu Asp 
                245                 250                 255     


Ser Pro Thr Asp Leu Ser Ser Pro Thr Asp Val Gly Leu Asp Cys Phe 
            260                 265                 270         


Phe Tyr Ile Ser Val Tyr Pro Gly Tyr Gly Val Glu Ile Lys Val Gln 
        275                 280                 285             


Asn Ile Ser Leu Arg Glu Gly Glu Thr Val Thr Val Glu Gly Leu Gly 
    290                 295                 300                 


Gly Pro Asp Pro Leu Pro Leu Ala Asn Gln Ser Phe Leu Leu Arg Gly 
305                 310                 315                 320 


Gln Val Ile Arg Ser Pro Thr His Gln Ala Ala Leu Arg Phe Gln Ser 
                325                 330                 335     


Leu Pro Pro Pro Ala Gly Pro Gly Thr Phe His Phe His Tyr Gln Ala 
            340                 345                 350         


Tyr Leu Leu Ser Cys His Phe Pro Arg Arg Pro Ala Tyr Gly Asp Val 
        355                 360                 365             


Thr Val Thr Ser Leu His Pro Gly Gly Ser Ala Arg Phe His Cys Ala 
    370                 375                 380                 


Thr Gly Tyr Gln Leu Lys Gly Ala Arg His Leu Thr Cys Leu Asn Ala 
385                 390                 395                 400 


Thr Gln Pro Phe Trp Asp Ser Lys Glu Pro Val Cys Ile Ala Ala Cys 
                405                 410                 415     


Gly Gly Val Ile Arg Asn Ala Thr Thr Gly Arg Ile Val Ser Pro Gly 
            420                 425                 430         


Phe Pro Gly Asn Tyr Ser Asn Asn Leu Thr Cys His Trp Leu Leu Glu 
        435                 440                 445             


Ala Pro Glu Gly Gln Arg Leu His Leu His Phe Glu Lys Val Ser Leu 
    450                 455                 460                 


Ala Glu Asp Asp Asp Arg Leu Ile Ile Arg Asn Gly Asp Asn Val Glu 
465                 470                 475                 480 


Ala Pro Pro Val Tyr Asp Ser Tyr Glu Val Glu Tyr Leu Pro Ile Glu 
                485                 490                 495     


Gly Leu Leu Ser Ser Gly Lys His Phe Phe Val Glu Leu Ser Thr Asp 
            500                 505                 510         


Ser Ser Gly Ala Ala Ala Gly Met Ala Leu Arg Tyr Glu Ala Phe Gln 
        515                 520                 525             


Gln Gly His Cys Tyr Glu Pro Phe Val Lys Tyr Gly Asn Phe Ser Ser 
    530                 535                 540                 


Ser Thr Pro Thr Tyr Pro Val Gly Thr Thr Val Glu Phe Ser Cys Asp 
545                 550                 555                 560 


Pro Gly Tyr Thr Leu Glu Gln Gly Ser Ile Ile Ile Glu Cys Val Asp 
                565                 570                 575     


Pro His Asp Pro Gln Trp Asn Glu Thr Glu Pro Ala Cys Arg Ala Val 
            580                 585                 590         


Cys Ser Gly Glu Ile Thr Asp Ser Ala Gly Val Val Leu Ser Pro Asn 
        595                 600                 605             


Trp Pro Glu Pro Tyr Gly Arg Gly Gln Asp Cys Ile Trp Gly Val His 
    610                 615                 620                 


Val Glu Glu Asp Lys Arg Ile Met Leu Asp Ile Arg Val Leu Arg Ile 
625                 630                 635                 640 


Gly Pro Gly Asp Val Leu Thr Phe Tyr Asp Gly Asp Asp Leu Thr Ala 
                645                 650                 655     


Arg Val Leu Gly Gln Tyr Ser Gly Pro Arg Ser His Phe Lys Leu Phe 
            660                 665                 670         


Thr Ser Met Ala Asp Val Thr Ile Gln Phe Gln Ser Asp Pro Gly Thr 
        675                 680                 685             


Ser Val Leu Gly Tyr Gln Gln Gly Phe Val Ile His Phe Phe Glu Val 
    690                 695                 700                 


Pro Arg Asn Asp Thr Cys Pro Glu Leu Pro Glu Ile Pro Asn Gly Trp 
705                 710                 715                 720 


Lys Ser Pro Ser Gln Pro Glu Leu Val His Gly Thr Val Val Thr Tyr 
                725                 730                 735     


Gln Cys Tyr Pro Gly Tyr Gln Val Val Gly Ser Ser Val Leu Met Cys 
            740                 745                 750         


Gln Trp Asp Leu Thr Trp Ser Glu Asp Leu Pro Ser Cys Gln Arg Val 
        755                 760                 765             


Thr Ser Cys His Asp Pro Gly Asp Val Glu His Ser Arg Arg Leu Ile 
    770                 775                 780                 


Ser Ser Pro Lys Phe Pro Val Gly Ala Thr Val Gln Tyr Ile Cys Asp 
785                 790                 795                 800 


Gln Gly Phe Val Leu Met Gly Ser Ser Ile Leu Thr Cys His Asp Arg 
                805                 810                 815     


Gln Ala Gly Ser Pro Lys Trp Ser Asp Arg Ala Pro Lys Cys Leu Leu 
            820                 825                 830         


Glu Gln Leu Lys Pro Cys His Gly Leu Ser Ala Pro Glu Asn Gly Ala 
        835                 840                 845             


Arg Ser Pro Glu Lys Gln Leu His Pro Ala Gly Ala Thr Ile His Phe 
    850                 855                 860                 


Ser Cys Ala Pro Gly Tyr Val Leu Lys Gly Gln Ala Ser Ile Lys Cys 
865                 870                 875                 880 


Val Pro Gly His Pro Ser His Trp Ser Asp Pro Pro Pro Ile Cys Arg 
                885                 890                 895     


Ala Ala Ser Leu Asp Gly Phe Tyr Asn Ser Arg Ser Leu Asp Val Ala 
            900                 905                 910         


Lys Ala Pro Ala Ala Ser Ser Thr Leu Asp Ala Ala His Ile Ala Ala 
        915                 920                 925             


Ala Ile Phe Leu Pro Leu Val Ala Met Val Leu Leu Val Gly Gly Val 
    930                 935                 940                 


Tyr Phe Tyr Phe Ser Arg Leu Gln Gly Lys Ser Ser Leu Gln Leu Pro 
945                 950                 955                 960 


Arg Pro Arg Pro Arg Pro Tyr Asn Arg Ile Thr Ile Glu Ser Ala Phe 
                965                 970                 975     


Asp Asn Pro Thr Tyr Glu Thr Gly Ser Leu Ser Phe Ala Gly Asp Glu 
            980                 985                 990         


Arg Ile 
        


<210>  2
<211>  993
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Pro Val Ala Leu Leu Leu Leu Pro Ser Leu Leu Ala Leu Leu 
1               5                   10                  15      


Ala His Gly Leu Ser Leu Glu Ala Pro Thr Val Gly Lys Gly Gln Ala 
            20                  25                  30          


Pro Gly Ile Glu Glu Thr Asp Gly Glu Leu Thr Ala Ala Pro Thr Pro 
        35                  40                  45              


Glu Gln Pro Glu Arg Gly Val His Phe Val Thr Thr Ala Pro Thr Leu 
    50                  55                  60                  


Lys Leu Leu Asn His His Pro Leu Leu Glu Glu Phe Leu Gln Glu Gly 
65                  70                  75                  80  


Leu Glu Lys Gly Asp Glu Glu Leu Arg Pro Ala Leu Pro Phe Gln Pro 
                85                  90                  95      


Asp Pro Pro Ala Pro Phe Thr Pro Ser Pro Leu Pro Arg Leu Ala Asn 
            100                 105                 110         


Gln Asp Ser Arg Pro Val Phe Thr Ser Pro Thr Pro Ala Met Ala Ala 
        115                 120                 125             


Val Pro Thr Gln Pro Gln Ser Lys Glu Gly Pro Trp Ser Pro Glu Ser 
    130                 135                 140                 


Glu Ser Pro Met Leu Arg Ile Thr Ala Pro Leu Pro Pro Gly Pro Ser 
145                 150                 155                 160 


Met Ala Val Pro Thr Leu Gly Pro Gly Glu Ile Ala Ser Thr Thr Pro 
                165                 170                 175     


Pro Ser Arg Ala Trp Thr Pro Thr Gln Glu Gly Pro Gly Asp Met Gly 
            180                 185                 190         


Arg Pro Trp Val Ala Glu Val Val Ser Gln Gly Ala Gly Ile Gly Ile 
        195                 200                 205             


Gln Gly Thr Ile Thr Ser Ser Thr Ala Ser Gly Asp Asp Glu Glu Thr 
    210                 215                 220                 


Thr Thr Thr Thr Thr Ile Ile Thr Thr Thr Ile Thr Thr Val Gln Thr 
225                 230                 235                 240 


Pro Gly Pro Cys Ser Trp Asn Phe Ser Gly Pro Glu Gly Ser Leu Asp 
                245                 250                 255     


Ser Pro Thr Asp Leu Ser Ser Pro Thr Asp Val Gly Leu Asp Cys Phe 
            260                 265                 270         


Phe Tyr Ile Ser Val Tyr Pro Gly Tyr Gly Val Glu Ile Lys Val Gln 
        275                 280                 285             


Asn Ile Ser Leu Arg Glu Gly Glu Thr Val Thr Val Glu Gly Leu Gly 
    290                 295                 300                 


Gly Pro Asp Pro Leu Pro Leu Ala Asn Gln Ser Phe Leu Leu Arg Gly 
305                 310                 315                 320 


Gln Val Ile Arg Ser Pro Thr His Gln Ala Ala Leu Arg Phe Gln Ser 
                325                 330                 335     


Leu Pro Pro Pro Ala Gly Pro Gly Thr Phe His Phe His Tyr Gln Ala 
            340                 345                 350         


Tyr Leu Leu Ser Cys His Phe Pro Arg Arg Pro Ala Tyr Gly Asp Val 
        355                 360                 365             


Thr Val Thr Ser Leu His Pro Gly Gly Ser Ala Arg Phe His Cys Ala 
    370                 375                 380                 


Thr Gly Tyr Gln Leu Lys Gly Ala Arg His Leu Thr Cys Leu Asn Ala 
385                 390                 395                 400 


Thr Gln Pro Phe Trp Asp Ser Lys Glu Pro Val Cys Ile Ala Ala Cys 
                405                 410                 415     


Gly Gly Val Ile Arg Asn Ala Thr Thr Gly Arg Ile Val Ser Pro Gly 
            420                 425                 430         


Phe Pro Gly Asn Tyr Ser Asn Asn Leu Thr Cys His Trp Leu Leu Glu 
        435                 440                 445             


Ala Pro Glu Gly Gln Arg Leu His Leu His Phe Glu Lys Val Ser Leu 
    450                 455                 460                 


Ala Glu Asp Asp Asp Arg Leu Ile Ile Arg Asn Gly Asp Asn Val Glu 
465                 470                 475                 480 


Ala Pro Pro Val Tyr Asp Ser Tyr Glu Val Glu Tyr Leu Pro Ile Glu 
                485                 490                 495     


Gly Leu Leu Ser Ser Gly Lys His Phe Phe Val Glu Leu Ser Thr Asp 
            500                 505                 510         


Ser Ser Gly Ala Ala Ala Gly Met Ala Leu Arg Tyr Glu Ala Phe Gln 
        515                 520                 525             


Gln Gly His Cys Tyr Glu Pro Phe Val Lys Tyr Gly Asn Phe Ser Ser 
    530                 535                 540                 


Ser Thr Pro Thr Tyr Pro Val Gly Thr Thr Val Glu Phe Ser Cys Asp 
545                 550                 555                 560 


Pro Gly Tyr Thr Leu Glu Gln Gly Ser Ile Ile Ile Glu Cys Val Asp 
                565                 570                 575     


Pro His Asp Pro Gln Trp Asn Glu Thr Glu Pro Ala Cys Arg Ala Val 
            580                 585                 590         


Cys Ser Gly Glu Ile Thr Asp Ser Ala Gly Val Val Leu Ser Pro Asn 
        595                 600                 605             


Trp Pro Glu Pro Tyr Gly Arg Gly Gln Asp Cys Ile Trp Gly Val His 
    610                 615                 620                 


Val Glu Glu Asp Lys Arg Ile Met Leu Asp Ile Arg Val Leu Arg Ile 
625                 630                 635                 640 


Gly Pro Gly Asp Val Leu Thr Phe Tyr Asp Gly Asp Asp Leu Thr Ala 
                645                 650                 655     


Arg Val Leu Gly Gln Tyr Ser Gly Pro Arg Ser His Phe Lys Leu Phe 
            660                 665                 670         


Thr Ser Met Ala Asp Val Thr Ile Gln Phe Gln Ser Asp Pro Gly Thr 
        675                 680                 685             


Ser Val Leu Gly Tyr Gln Gln Gly Phe Val Ile His Phe Phe Glu Val 
    690                 695                 700                 


Pro Arg Asn Asp Thr Cys Pro Glu Leu Pro Glu Ile Pro Asn Gly Trp 
705                 710                 715                 720 


Lys Ser Pro Ser Gln Pro Glu Leu Val His Gly Thr Val Val Thr Tyr 
                725                 730                 735     


Gln Cys Tyr Pro Gly Tyr Gln Val Val Gly Ser Ser Val Leu Met Cys 
            740                 745                 750         


Gln Trp Asp Leu Thr Trp Ser Glu Asp Leu Pro Ser Cys Gln Arg Val 
        755                 760                 765             


Thr Ser Cys His Asp Pro Gly Asp Val Glu His Ser Arg Arg Leu Ile 
    770                 775                 780                 


Ser Ser Pro Lys Phe Pro Val Gly Ala Thr Val Gln Tyr Ile Cys Asp 
785                 790                 795                 800 


Gln Gly Phe Val Leu Met Gly Ser Ser Ile Leu Thr Cys His Asp Arg 
                805                 810                 815     


Gln Ala Gly Ser Pro Lys Trp Ser Asp Arg Ala Pro Lys Cys Leu Leu 
            820                 825                 830         


Glu Gln Leu Lys Pro Cys His Gly Leu Ser Ala Pro Glu Asn Gly Ala 
        835                 840                 845             


Arg Ser Pro Glu Lys Gln Leu His Pro Ala Gly Ala Thr Ile His Phe 
    850                 855                 860                 


Ser Cys Ala Pro Gly Tyr Val Leu Lys Gly Gln Ala Ser Ile Lys Cys 
865                 870                 875                 880 


Val Pro Gly His Pro Ser His Trp Ser Asp Pro Pro Pro Ile Cys Arg 
                885                 890                 895     


Ala Ala Ser Leu Asp Gly Phe Tyr Asn Ser Arg Ser Leu Asp Val Ala 
            900                 905                 910         


Lys Ala Pro Ala Ala Ser Ser Thr Leu Asp Ala Ala His Ile Ala Ala 
        915                 920                 925             


Ala Ile Phe Leu Pro Leu Val Ala Met Val Leu Leu Val Gly Gly Val 
    930                 935                 940                 


Tyr Phe Tyr Phe Ser Arg Leu Gln Gly Lys Ser Ser Leu Gln Leu Pro 
945                 950                 955                 960 


Arg Pro Arg Pro Arg Pro Tyr Asn Arg Ile Thr Ile Glu Ser Ala Phe 
                965                 970                 975     


Asp Asn Pro Thr Tyr Glu Thr Gly Glu Thr Arg Glu Tyr Glu Val Ser 
            980                 985                 990         


Ile 
    


<210>  3
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Ser 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Glu Gly Asp Thr Asn Tyr Asn Gly Asn Phe 
    50                  55                  60                  


Glu Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Leu Val Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 


<210>  4
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asp Tyr Asn 
            20                  25                  30          


Gly Ile Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Ala Ala Ser Asn Val Gln Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ile 
                85                  90                  95      


Glu Asp Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  5
<211>  1938
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  5
gaagtccaac tcgtccaatc cggtgccgaa gtgaaaaagc ctggggaatc cctgaagatc       60

agctgcaagg gatccggtta ctcgttcacc tcctcctgga ttaactgggt ccggcagatg      120

cccggaaagg gactggagtg gatgggcaga atctatccgg gcgaagggga cactaattac      180

aacggaaact tcgagggcca ggtcaccatt tcggccgata agagcatctc aaccgcgtac      240

ttgcagtggt caagcctgaa ggcttccgac accgccatgt actactgtac tcgcggcctt      300

gtgatggact actggggaca gggaactctc gtgaccgtgt cgtccgcctc taccaagggc      360

ccttccgtgt tccctctggc cccctcgagc aagagcacct ctgggggcac agcggccctg      420

ggctgcctgg tcaaggacta cttccccgag ccggtgacgg tgtcgtggaa ctcaggcgcc      480

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      540

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      600

aatcacaagc ccagcaacac caaggtggac aagaaagttg gtgagaggcc agcacaggga      660

gggagggtgt ctgctggaag ccaggctcag cgctcctgcc tggacgcatc ccggctatgc      720

agccccagtc cagggcagca aggcaggccc cgtctgcctc ttcacccgga ggcctctgcc      780

cgccccactc atgctcaggg agagggtctt ctggcttttt ccccaggctc tgggcaggca      840

caggctaggt gcccctaacc caggccctgc acacaaaggg gcaggtgctg ggctcagacc      900

tgccaagagc catatccggg aggaccctgc ccctgaccta agcccacccc aaaggccaaa      960

ctctccactc cctcagctcg gacaccttct ctcctcccag attccagtaa ctcccaatct     1020

tctctctgca gagcccaaat ctagtgacaa aactcacaca tgcccaccgt gcccaggtaa     1080

gccagcccag gcctcgccct ccagctcaag gcgggacagg tgccctagag tagcctgcat     1140

ccagggacag gccccagccg ggtgctgaca cgtccacctc catctcttcc tcagcacctg     1200

aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac accctcatga     1260

tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa gaccctgagg     1320

tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca aagccgcggg     1380

aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg caccaggact     1440

ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca gcccccatcg     1500

agaaaaccat ctccaaagcc aaaggtggga cccgtggggt gcgagggcca catggacaga     1560

ggccggctcg gcccaccctc tgccctgaga gtgaccgctg taccaacctc tgtccctaca     1620

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag     1680

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1740

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1800

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1860

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1920

ctctccctgt ctccgggt                                                   1938


<210>  6
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  6
gaaatcgtgt tgacccagtc ccccgctacc ctgtcactga gccccggaga acgcgcgact       60

ctgtcctgcc gggcatccca gtccgtggac tacaacggaa tctcctacat gcactggtat      120

cagcaaaagc caggccaagc cccgagactg ctcatctacg ccgcctcgaa cgtgcagagc      180

ggtattccgg cgcggttctc cggctcgggc agcggaaccg attttaccct cactatctcg      240

tcacttgaac ctgaggactt cgccgtgtac tactgccagc agtccattga ggacccgcct      300

actttcgggg ggggaaccaa agtcgagatc aagcggactg tggctgcacc aagtgtcttc      360

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      420

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg      480

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      540

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc      600

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgt            654


<210>  7
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  7

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Ser 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Glu Gly Asp Thr Asn Tyr Asn Gly Asn Phe 
    50                  55                  60                  


Glu Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Leu Val Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  8
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asp Tyr Asn 
            20                  25                  30          


Gly Ile Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Ala Ala Ser Asn Val Gln Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ile 
                85                  90                  95      


Glu Asp Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


