                         SEQUENCE LISTING

<110>  KOHN, DONALD B.
       KUO, CAROLINE Y.
       GRAY, DAVID
       ROMERO GARCIA, ZULEMA
       HOLLIS, ROGER P.
       LOMOVA, ANASTASIA
 
<120>  GENE EDITING OF MONOGENIC DISORDERS IN HUMAN HEMATOPOIETIC STEM 
       CELLS -- CORRECTION OF X-LINKED AGAMMAGLOBULINEMIA (XLA)

<130>  UCLAP201BWO

<140>  PCT/US2019/034715
<141>  2019-05-30

<150>  US 62/678,218
<151>  2018-05-30

<150>  US 62/760,448
<151>  2018-11-13

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  1
ctctggactg taagaatatg                                                   20


<210>  2
<211>  3680
<212>  DNA
<213>  Homo sapiens

<400>  2
ttgtcctttg gggtcccttc actatcaagt tcaactgtgt gtccctgaga ctcctctgcc       60

ccggaggaca ggagactcga aaaacgctct tcctggccag tctctttgct ctgtgtctgc      120

cagcccccag catctctcct ctttcctgta agcccctctc cctgtgctga ctgtcttcat      180

agtactttag gtatgttgtc cctttacctc tgggaggata gcttgatgac ctgtctgctc      240

aggccagccc catctagagt ctcagtggcc ccagtcatgt tgagaaaggt tctttcaaag      300

atagactcaa gatagtagtg tcagaggtcc caagcaaatg aagggcgggg acagttgagg      360

gggtggaata gggacggcag cagggaacca gatagcatgc tgctgagaag aaaaaaagac      420

attggtttag gtcaggaagc aaaaaaaggg aactgagtgg ctgtgaaagg gtggggtttg      480

ctcagactgt ccttcctctc tggactgtaa gaatatgtct ccagggccag tgtctgctgc      540

gatcgagtcc caccttccaa gtcctggcat ctcaatgcat ctgggaagct acctgcatta      600

agtcaggact gagcacacag gtgaactcca gaaagaagaa gctatggccg ccgtgatcct      660

ggaatccatc ttcctgaagc ggagccagca gaagaagaaa acaagccctc tgaacttcaa      720

gaagcggctg ttcctgctga ccgtgcacaa gctgagctac tacgagtacg acttcgagcg      780

gggcagaaga ggcagcaaga aaggcagcat cgacgtggaa aagatcacct gtgtggaaac      840

cgtggtgccc gagaagaacc ctccacctga gagacagatc cccagaaggg gcgaagagtc      900

cagcgagatg gaacagatct ctatcatcga gcggttcccg tatcctttcc aagtggtgta      960

cgacgagggc ccactgtacg tgttcagccc taccgaggaa ctgcggaaga gatggatcca     1020

ccagctgaag aacgtgatcc ggtacaacag cgacctggtg cagaagtatc acccctgctt     1080

ttggatcgac ggccagtacc tgtgctgtag ccagaccgcc aagaatgcca tgggctgcca     1140

gattctggaa aaccggaacg gctctctgaa gcccggcagc agccacagaa agaccaagaa     1200

gcctctgcct cctacacctg aagaggacca gatcctgaag aaacccctgc ctccagaacc     1260

tgccgctgct cctgtgtcta ccagcgagct gaaaaaggtg gtggccctgt acgactacat     1320

gcccatgaac gccaacgacc tgcagctgag aaagggcgac gagtacttca tcctggaaga     1380

gtctaacctg ccttggtggc gggccagaga caagaatggc caagagggct acatccccag     1440

caactacgtg accgaggccg aggacagcat cgagatgtac gagtggtaca gcaagcacat     1500

gaccagaagc caggccgaac agctgctgaa gcaagagggc aaagaaggcg gcttcatcgt     1560

ccgggattct agcaaggccg gcaagtacac cgtgtccgtg ttcgccaaga gcaccggcga     1620

tcctcagggc gtgatcagac actacgtcgt gtgtagcacc cctcagagcc agtactacct     1680

ggccgagaag cacctgttca gcacaatccc cgagctgatc aactaccacc agcacaactc     1740

tgccggcctg atcagcagac tgaagtaccc tgtgtctcag cagaacaaaa acgcccctag     1800

cacagccggc ctcggctatg gatcttggga gatcgacccc aaggacctga ccttcctgaa     1860

agaactcggc accggccagt tcggcgtcgt gaagtatgga aaatggcggg gacagtacga     1920

cgtggccatc aagatgatca aagagggcag catgagcgag gacgagttca tcgaagaggc     1980

caaagtgatg atgaacctga gccacgagaa gctggtgcag ctgtacggcg tgtgtaccaa     2040

gcagcggccc atctttatca tcaccgagta catggccaac ggctgcctgc tgaactacct     2100

gcgcgaaatg cggcaccggt ttcagacaca gcaactgctg gaaatgtgca aggacgtgtg     2160

cgaggccatg gaatacctgg aaagcaagca gttcctgcac cgcgatctgg ccgccagaaa     2220

ctgcctggtc aatgatcagg gcgttgtgaa ggtgtccgac ttcggcctga gcagatacgt     2280

gctggacgat gagtacacca gcagcgtggg cagcaagttt cccgtcagat ggtccccacc     2340

tgaggtgctg atgtactcca agttcagctc caagagcgac atctgggcct tcggcgttct     2400

gatgtgggag atctacagcc tgggcaagat gccctacgag agattcacca acagcgagac     2460

agccgagcac attgcccagg gcctgagact gtatagacct cacctggcct ccgagaaggt     2520

gtacacaatc atgtacagct gttggcacga gaaggccgac gagcggccta cctttaagat     2580

cctgctgagc aacatcctgg acgtgatgga cgaggaatcc ggtggaggcg gtggagggta     2640

cccatacgat gttccagatt acgcttatcc gtacgacgtc ccggattacg cttatcccta     2700

tgacgtgcct gattatgctt gagctcgcca ataagcttct tggttctact tctcttctcc     2760

acaagcccca atttcacttt ctcagaggaa atcccaagct taggagccct ggagcctttg     2820

tgctcccact caatacaaaa aggcccctct ctacatctgg gaatgcacct cttctttgat     2880

tccctgggat agtggcttct gagcaaaggc caagaaatta ttgtgcctga aatttcccga     2940

gagaattaag acagactgaa tttgcgatga aaatattttt taggagggag gatgtaaata     3000

gccgcacaaa ggggtccaac agctctttga gtaggcattt ggtagagctt gggggtgtgt     3060

gtgtgggggt ggaccgaatt tggcaagaat gaaatggtgt cataaagatg ggaggggagg     3120

gtgttttgat aaaataaaat tactagaaag cattagatct gtgtgttggt tttttgtgtg     3180

tggactgtaa gaatatgtct ccagggccag tgtctgctgc gatcgagtcc caccttccaa     3240

gtcctggcat ctcaatgcat ctgggaagct acctgcatta agtcaggact gaggtgggtc     3300

tggggtatgg caggggctgg gcagcagcag caatgtacct tgcttgggac ccctaaaaac     3360

cagagagaca gcatggctgg tgccatttat cagctagtgg aggaggctga cggagggtgg     3420

gagtgtcatc agcacaaggc cctggcagtc ccttctggtg attagagagg ccgaaagggt     3480

cctttccgac aagggctgag ggtgggcgga acaggaagag aaaaatgtga catgaggtga     3540

ccatccgaac aggtagcaaa tgttagaaag gggtacctct ggcaaactta gtggaaaagt     3600

aatattgcag ggagcagtca gataaaaaca agcccttctg tcaaatagtg cttgaagact     3660

caatagggat acatgggtca                                                 3680


<210>  3
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  3
agggatgagg attaatgtcc                                                   20


<210>  4
<211>  3600
<212>  DNA
<213>  Artificial

<220>
<223>  BTK Intron 1 Original HDR Donor Seq excluding backbone

<400>  4
cctccatatc cttattagtt cccttggtta cagaccccag tgggacaatg tttgaaaaat       60

tatattcacc gtctaggaaa ttgggaactg aaagtccaat atctgcctca gtggagttct      120

ggcacctgca ttatcccttc tgggtatatc aagatcaaca gctgcacaga tacttttgct      180

tttcacagat tctacacata tcatataaag gtgaatagtg taaagctacc tctacacctt      240

accaagcaca caggtgcgtg ccatttaaca tctagagcat tccattgcct tatacaagaa      300

ctcagtttat atgagctcac aacatcgaac caatcccccc ccaattcagt gtgcatccat      360

tatacctgaa acctgacaga gctgggggct gtgggaggag gttggtagga agaaattatt      420

ttgtgagctg tgcacatttt tgttccattt gaaactaggt agctaggctg agggggaacc      480

aagagggatg aggattaatg tcctgggtcc tcaggaactt tcattatcaa cagcacacag      540

gtgaactcca gaaagaagaa gctatggccg ccgtgatcct ggaatccatc ttcctgaagc      600

ggagccagca gaagaagaaa acaagccctc tgaacttcaa gaagcggctg ttcctgctga      660

ccgtgcacaa gctgagctac tacgagtacg acttcgagcg gggcagaaga ggcagcaaga      720

aaggcagcat cgacgtggaa aagatcacct gtgtggaaac cgtggtgccc gagaagaacc      780

ctccacctga gagacagatc cccagaaggg gcgaagagtc cagcgagatg gaacagatct      840

ctatcatcga gcggttcccg tatcctttcc aagtggtgta cgacgagggc ccactgtacg      900

tgttcagccc taccgaggaa ctgcggaaga gatggatcca ccagctgaag aacgtgatcc      960

ggtacaacag cgacctggtg cagaagtatc acccctgctt ttggatcgac ggccagtacc     1020

tgtgctgtag ccagaccgcc aagaatgcca tgggctgcca gattctggaa aaccggaacg     1080

gctctctgaa gcccggcagc agccacagaa agaccaagaa gcctctgcct cctacacctg     1140

aagaggacca gatcctgaag aaacccctgc ctccagaacc tgccgctgct cctgtgtcta     1200

ccagcgagct gaaaaaggtg gtggccctgt acgactacat gcccatgaac gccaacgacc     1260

tgcagctgag aaagggcgac gagtacttca tcctggaaga gtctaacctg ccttggtggc     1320

gggccagaga caagaatggc caagagggct acatccccag caactacgtg accgaggccg     1380

aggacagcat cgagatgtac gagtggtaca gcaagcacat gaccagaagc caggccgaac     1440

agctgctgaa gcaagagggc aaagaaggcg gcttcatcgt ccgggattct agcaaggccg     1500

gcaagtacac cgtgtccgtg ttcgccaaga gcaccggcga tcctcagggc gtgatcagac     1560

actacgtcgt gtgtagcacc cctcagagcc agtactacct ggccgagaag cacctgttca     1620

gcacaatccc cgagctgatc aactaccacc agcacaactc tgccggcctg atcagcagac     1680

tgaagtaccc tgtgtctcag cagaacaaaa acgcccctag cacagccggc ctcggctatg     1740

gatcttggga gatcgacccc aaggacctga ccttcctgaa agaactcggc accggccagt     1800

tcggcgtcgt gaagtatgga aaatggcggg gacagtacga cgtggccatc aagatgatca     1860

aagagggcag catgagcgag gacgagttca tcgaagaggc caaagtgatg atgaacctga     1920

gccacgagaa gctggtgcag ctgtacggcg tgtgtaccaa gcagcggccc atctttatca     1980

tcaccgagta catggccaac ggctgcctgc tgaactacct gcgcgaaatg cggcaccggt     2040

ttcagacaca gcaactgctg gaaatgtgca aggacgtgtg cgaggccatg gaatacctgg     2100

aaagcaagca gttcctgcac cgcgatctgg ccgccagaaa ctgcctggtc aatgatcagg     2160

gcgttgtgaa ggtgtccgac ttcggcctga gcagatacgt gctggacgat gagtacacca     2220

gcagcgtggg cagcaagttt cccgtcagat ggtccccacc tgaggtgctg atgtactcca     2280

agttcagctc caagagcgac atctgggcct tcggcgttct gatgtgggag atctacagcc     2340

tgggcaagat gccctacgag agattcacca acagcgagac agccgagcac attgcccagg     2400

gcctgagact gtatagacct cacctggcct ccgagaaggt gtacacaatc atgtacagct     2460

gttggcacga gaaggccgac gagcggccta cctttaagat cctgctgagc aacatcctgg     2520

acgtgatgga cgaggaatcc ggtggaggcg gtggagggta cccatacgat gttccagatt     2580

acgcttatcc gtacgacgtc ccggattacg cttatcccta tgacgtgcct gattatgctt     2640

gagctcgcca ataagcttct tggttctact tctcttctcc acaagcccca atttcacttt     2700

ctcagaggaa atcccaagct taggagccct ggagcctttg tgctcccact caatacaaaa     2760

aggcccctct ctacatctgg gaatgcacct cttctttgat tccctgggat agtggcttct     2820

gagcaaaggc caagaaatta ttgtgcctga aatttcccga gagaattaag acagactgaa     2880

tttgcgatga aaatattttt taggagggag gatgtaaata gccgcacaaa ggggtccaac     2940

agctctttga gtaggcattt ggtagagctt gggggtgtgt gtgtgggggt ggaccgaatt     3000

tggcaagaat gaaatggtgt cataaagatg ggaggggagg gtgttttgat aaaataaaat     3060

tactagaaag cattagatct gtgtgttggt tttttgtgtg tcctgggtcc tcaggaactt     3120

tcattatcaa cagcacacag gtgaactcca gaaagaagaa gctatggccg cagtgattct     3180

ggagagcatc tttctgaagc gatcccaaca gaaaaagaaa acatcacctc taaacttcaa     3240

gaagcgcctg tttctcttga ccgtgcacaa actctcctac tatgagtatg actttgaacg     3300

tggggtaagt ttctcgacta tgaaaactga gtttcaagat atcaaggact tggccttaga     3360

tctttcttgg ggaagaggta aattttcgtt ggtaggagga ggggagtaga atggacctaa     3420

gttctttcaa attcagcaaa atatttccta gcctataact agctaaagcc ggaaagtcaa     3480

aggtcctaag aagccacaag gaaaatatta ccatggaatc ttggaattga tgagcactca     3540

ttaaatgatt gttgaaaatg aaatcgaaga gttggaaatt gcttccttac ttcctatgag     3600


<210>  5
<211>  3600
<212>  DNA
<213>  Artificial

<220>
<223>  BTK Intron 1 HDR PAM Mutated Donor Excluding backbone

<400>  5
cctccatatc cttattagtt cccttggtta cagaccccag tgggacaatg tttgaaaaat       60

tatattcacc gtctaggaaa ttgggaactg aaagtccaat atctgcctca gtggagttct      120

ggcacctgca ttatcccttc tgggtatatc aagatcaaca gctgcacaga tacttttgct      180

tttcacagat tctacacata tcatataaag gtgaatagtg taaagctacc tctacacctt      240

accaagcaca caggtgcgtg ccatttaaca tctagagcat tccattgcct tatacaagaa      300

ctcagtttat atgagctcac aacatcgaac caatcccccc ccaattcagt gtgcatccat      360

tatacctgaa acctgacaga gctgggggct gtgggaggag gttggtagga agaaattatt      420

ttgtgagctg tgcacatttt tgttccattt gaaactaggt agctaggctg agggggaacc      480

aagagggatg aggattaatg tcctaagtcc tcaggaactt tcattatcaa cagcacacag      540

gtgaactcca gaaagaagaa gctatggccg ccgtgatcct ggaatccatc ttcctgaagc      600

ggagccagca gaagaagaaa acaagccctc tgaacttcaa gaagcggctg ttcctgctga      660

ccgtgcacaa gctgagctac tacgagtacg acttcgagcg gggcagaaga ggcagcaaga      720

aaggcagcat cgacgtggaa aagatcacct gtgtggaaac cgtggtgccc gagaagaacc      780

ctccacctga gagacagatc cccagaaggg gcgaagagtc cagcgagatg gaacagatct      840

ctatcatcga gcggttcccg tatcctttcc aagtggtgta cgacgagggc ccactgtacg      900

tgttcagccc taccgaggaa ctgcggaaga gatggatcca ccagctgaag aacgtgatcc      960

ggtacaacag cgacctggtg cagaagtatc acccctgctt ttggatcgac ggccagtacc     1020

tgtgctgtag ccagaccgcc aagaatgcca tgggctgcca gattctggaa aaccggaacg     1080

gctctctgaa gcccggcagc agccacagaa agaccaagaa gcctctgcct cctacacctg     1140

aagaggacca gatcctgaag aaacccctgc ctccagaacc tgccgctgct cctgtgtcta     1200

ccagcgagct gaaaaaggtg gtggccctgt acgactacat gcccatgaac gccaacgacc     1260

tgcagctgag aaagggcgac gagtacttca tcctggaaga gtctaacctg ccttggtggc     1320

gggccagaga caagaatggc caagagggct acatccccag caactacgtg accgaggccg     1380

aggacagcat cgagatgtac gagtggtaca gcaagcacat gaccagaagc caggccgaac     1440

agctgctgaa gcaagagggc aaagaaggcg gcttcatcgt ccgggattct agcaaggccg     1500

gcaagtacac cgtgtccgtg ttcgccaaga gcaccggcga tcctcagggc gtgatcagac     1560

actacgtcgt gtgtagcacc cctcagagcc agtactacct ggccgagaag cacctgttca     1620

gcacaatccc cgagctgatc aactaccacc agcacaactc tgccggcctg atcagcagac     1680

tgaagtaccc tgtgtctcag cagaacaaaa acgcccctag cacagccggc ctcggctatg     1740

gatcttggga gatcgacccc aaggacctga ccttcctgaa agaactcggc accggccagt     1800

tcggcgtcgt gaagtatgga aaatggcggg gacagtacga cgtggccatc aagatgatca     1860

aagagggcag catgagcgag gacgagttca tcgaagaggc caaagtgatg atgaacctga     1920

gccacgagaa gctggtgcag ctgtacggcg tgtgtaccaa gcagcggccc atctttatca     1980

tcaccgagta catggccaac ggctgcctgc tgaactacct gcgcgaaatg cggcaccggt     2040

ttcagacaca gcaactgctg gaaatgtgca aggacgtgtg cgaggccatg gaatacctgg     2100

aaagcaagca gttcctgcac cgcgatctgg ccgccagaaa ctgcctggtc aatgatcagg     2160

gcgttgtgaa ggtgtccgac ttcggcctga gcagatacgt gctggacgat gagtacacca     2220

gcagcgtggg cagcaagttt cccgtcagat ggtccccacc tgaggtgctg atgtactcca     2280

agttcagctc caagagcgac atctgggcct tcggcgttct gatgtgggag atctacagcc     2340

tgggcaagat gccctacgag agattcacca acagcgagac agccgagcac attgcccagg     2400

gcctgagact gtatagacct cacctggcct ccgagaaggt gtacacaatc atgtacagct     2460

gttggcacga gaaggccgac gagcggccta cctttaagat cctgctgagc aacatcctgg     2520

acgtgatgga cgaggaatcc ggtggaggcg gtggagggta cccatacgat gttccagatt     2580

acgcttatcc gtacgacgtc ccggattacg cttatcccta tgacgtgcct gattatgctt     2640

gagctcgcca ataagcttct tggttctact tctcttctcc acaagcccca atttcacttt     2700

ctcagaggaa atcccaagct taggagccct ggagcctttg tgctcccact caatacaaaa     2760

aggcccctct ctacatctgg gaatgcacct cttctttgat tccctgggat agtggcttct     2820

gagcaaaggc caagaaatta ttgtgcctga aatttcccga gagaattaag acagactgaa     2880

tttgcgatga aaatattttt taggagggag gatgtaaata gccgcacaaa ggggtccaac     2940

agctctttga gtaggcattt ggtagagctt gggggtgtgt gtgtgggggt ggaccgaatt     3000

tggcaagaat gaaatggtgt cataaagatg ggaggggagg gtgttttgat aaaataaaat     3060

tactagaaag cattagatct gtgtgttggt tttttgtgtg tcctgggtcc tcaggaactt     3120

tcattatcaa cagcacacag gtgaactcca gaaagaagaa gctatggccg cagtgattct     3180

ggagagcatc tttctgaagc gatcccaaca gaaaaagaaa acatcacctc taaacttcaa     3240

gaagcgcctg tttctcttga ccgtgcacaa actctcctac tatgagtatg actttgaacg     3300

tggggtaagt ttctcgacta tgaaaactga gtttcaagat atcaaggact tggccttaga     3360

tctttcttgg ggaagaggta aattttcgtt ggtaggagga ggggagtaga atggacctaa     3420

gttctttcaa attcagcaaa atatttccta gcctataact agctaaagcc ggaaagtcaa     3480

aggtcctaag aagccacaag gaaaatatta ccatggaatc ttggaattga tgagcactca     3540

ttaaatgatt gttgaaaatg aaatcgaaga gttggaaatt gcttccttac ttcctatgag     3600


<210>  6
<211>  4339
<212>  DNA
<213>  Artificial

<220>
<223>  BTK Intron 1 Donor with WPRE Excluding backbone

<400>  6
cctccatatc cttattagtt cccttggtta cagaccccag tgggacaatg tttgaaaaat       60

tatattcacc gtctaggaaa ttgggaactg aaagtccaat atctgcctca gtggagttct      120

ggcacctgca ttatcccttc tgggtatatc aagatcaaca gctgcacaga tacttttgct      180

tttcacagat tctacacata tcatataaag gtgaatagtg taaagctacc tctacacctt      240

accaagcaca caggtgcgtg ccatttaaca tctagagcat tccattgcct tatacaagaa      300

ctcagtttat atgagctcac aacatcgaac caatcccccc ccaattcagt gtgcatccat      360

tatacctgaa acctgacaga gctgggggct gtgggaggag gttggtagga agaaattatt      420

ttgtgagctg tgcacatttt tgttccattt gaaactaggt agctaggctg agggggaacc      480

aagagggatg aggattaatg tcctgggtcc tcaggaactt tcattatcaa cagcacacag      540

gtgaactcca gaaagaagaa gctatggccg ccgtgatcct ggaatccatc ttcctgaagc      600

ggagccagca gaagaagaaa acaagccctc tgaacttcaa gaagcggctg ttcctgctga      660

ccgtgcacaa gctgagctac tacgagtacg acttcgagcg gggcagaaga ggcagcaaga      720

aaggcagcat cgacgtggaa aagatcacct gtgtggaaac cgtggtgccc gagaagaacc      780

ctccacctga gagacagatc cccagaaggg gcgaagagtc cagcgagatg gaacagatct      840

ctatcatcga gcggttcccg tatcctttcc aagtggtgta cgacgagggc ccactgtacg      900

tgttcagccc taccgaggaa ctgcggaaga gatggatcca ccagctgaag aacgtgatcc      960

ggtacaacag cgacctggtg cagaagtatc acccctgctt ttggatcgac ggccagtacc     1020

tgtgctgtag ccagaccgcc aagaatgcca tgggctgcca gattctggaa aaccggaacg     1080

gctctctgaa gcccggcagc agccacagaa agaccaagaa gcctctgcct cctacacctg     1140

aagaggacca gatcctgaag aaacccctgc ctccagaacc tgccgctgct cctgtgtcta     1200

ccagcgagct gaaaaaggtg gtggccctgt acgactacat gcccatgaac gccaacgacc     1260

tgcagctgag aaagggcgac gagtacttca tcctggaaga gtctaacctg ccttggtggc     1320

gggccagaga caagaatggc caagagggct acatccccag caactacgtg accgaggccg     1380

aggacagcat cgagatgtac gagtggtaca gcaagcacat gaccagaagc caggccgaac     1440

agctgctgaa gcaagagggc aaagaaggcg gcttcatcgt ccgggattct agcaaggccg     1500

gcaagtacac cgtgtccgtg ttcgccaaga gcaccggcga tcctcagggc gtgatcagac     1560

actacgtcgt gtgtagcacc cctcagagcc agtactacct ggccgagaag cacctgttca     1620

gcacaatccc cgagctgatc aactaccacc agcacaactc tgccggcctg atcagcagac     1680

tgaagtaccc tgtgtctcag cagaacaaaa acgcccctag cacagccggc ctcggctatg     1740

gatcttggga gatcgacccc aaggacctga ccttcctgaa agaactcggc accggccagt     1800

tcggcgtcgt gaagtatgga aaatggcggg gacagtacga cgtggccatc aagatgatca     1860

aagagggcag catgagcgag gacgagttca tcgaagaggc caaagtgatg atgaacctga     1920

gccacgagaa gctggtgcag ctgtacggcg tgtgtaccaa gcagcggccc atctttatca     1980

tcaccgagta catggccaac ggctgcctgc tgaactacct gcgcgaaatg cggcaccggt     2040

ttcagacaca gcaactgctg gaaatgtgca aggacgtgtg cgaggccatg gaatacctgg     2100

aaagcaagca gttcctgcac cgcgatctgg ccgccagaaa ctgcctggtc aatgatcagg     2160

gcgttgtgaa ggtgtccgac ttcggcctga gcagatacgt gctggacgat gagtacacca     2220

gcagcgtggg cagcaagttt cccgtcagat ggtccccacc tgaggtgctg atgtactcca     2280

agttcagctc caagagcgac atctgggcct tcggcgttct gatgtgggag atctacagcc     2340

tgggcaagat gccctacgag agattcacca acagcgagac agccgagcac attgcccagg     2400

gcctgagact gtatagacct cacctggcct ccgagaaggt gtacacaatc atgtacagct     2460

gttggcacga gaaggccgac gagcggccta cctttaagat cctgctgagc aacatcctgg     2520

acgtgatgga cgaggaatcc ggtggaggcg gtggagggta cccatacgat gttccagatt     2580

acgcttatcc gtacgacgtc ccggattacg cttatcccta tgacgtgcct gattatgctt     2640

gagctcgcca ataagcttct tggttctact tctcttctcc acaagcccca atttcacttt     2700

ctcagaggaa atcccaagct taggagccct ggagcctttg tgctcccact caatacaaaa     2760

aggcccctct ctacatctgg gaatgcacct cttctttgat tccctgggat agtggcttct     2820

gagcaaaggc caagaaatta ttgtgcctga aatttcccga gagaattaag acagactgaa     2880

tttgcgatga aaatattttt taggagggag gatgtaaata gccgcacaaa ggggtccaac     2940

agctctttga gtaggcattt ggtagagctt gggggtgtgt gtgtgggggt ggaccgaatt     3000

tggcaagaat gaaatggtgt cataaagatg ggaggggagg gtggcctact cgaccacgag     3060

ggaattccga taatcaacct ctggattaca aaatttgtga aagattgact ggtattctta     3120

actatgttgc tccttttacg ctatgtggat acgctgcttt aatgcctttg tatcatgcta     3180

ttgcttcccg tatggctttc attttctcct ccttgtataa atcctggttg ctgtctcttt     3240

atgaggagtt gtggcccgtt gtcaggcaac gtggcgtggt gtgcactgtg tttgctgacg     3300

caacccccac tggttggggc attgccacca cctgtcagct cctttccggg actttcgctt     3360

tccccctccc tattgccacg gcggaactca tcgccgcctg ccttgcccgc tgctggacag     3420

gggctcggct gttgggcact gacaattccg tggtgttgtc ggggaaatca tcgtcctttc     3480

cttggctgct cgcctgtgtt gccacctgga ttctgcgcgg gacgtccttc tgctacgtcc     3540

cttcggccct caatccagcg gaccttcctt cccgcggcct gctgccggct ctgcggcctc     3600

ttccgcgtct tcgccttcgc cctcagacga gtcggatctc cctttgggcc gcctccccgc     3660

atcgataccg tcgacctcga gacctagaaa aacatggcca attcgagctc ggtaccttta     3720

agaccaatga cttacaaggc agctgtagat cttagccact ttttaaaaga aaagggggga     3780

cgttttgata aaataaaatt actagaaagc attagatctg tgtgttggtt ttttgtgtgt     3840

cctgggtcct caggaacttt cattatcaac agcacacagg tgaactccag aaagaagaag     3900

ctatggccgc agtgattctg gagagcatct ttctgaagcg atcccaacag aaaaagaaaa     3960

catcacctct aaacttcaag aagcgcctgt ttctcttgac cgtgcacaaa ctctcctact     4020

atgagtatga ctttgaacgt ggggtaagtt tctcgactat gaaaactgag tttcaagata     4080

tcaaggactt ggccttagat ctttcttggg gaagaggtaa attttcgttg gtaggaggag     4140

gggagtagaa tggacctaag ttctttcaaa ttcagcaaaa tatttcctag cctataacta     4200

gctaaagccg gaaagtcaaa ggtcctaaga agccacaagg aaaatattac catggaatct     4260

tggaattgat gagcactcat taaatgattg ttgaaaatga aatcgaagag ttggaaattg     4320

cttccttact tcctatgag                                                  4339


<210>  7
<211>  4279
<212>  DNA
<213>  Artificial

<220>
<223>  BTK Intron 1 Donor with Intron 18 truncated excluding backbone

<400>  7
cctccatatc cttattagtt cccttggtta cagaccccag tgggacaatg tttgaaaaat       60

tatattcacc gtctaggaaa ttgggaactg aaagtccaat atctgcctca gtggagttct      120

ggcacctgca ttatcccttc tgggtatatc aagatcaaca gctgcacaga tacttttgct      180

tttcacagat tctacacata tcatataaag gtgaatagtg taaagctacc tctacacctt      240

accaagcaca caggtgcgtg ccatttaaca tctagagcat tccattgcct tatacaagaa      300

ctcagtttat atgagctcac aacatcgaac caatcccccc ccaattcagt gtgcatccat      360

tatacctgaa acctgacaga gctgggggct gtgggaggag gttggtagga agaaattatt      420

ttgtgagctg tgcacatttt tgttccattt gaaactaggt agctaggctg agggggaacc      480

aagagggatg aggattaatg tcctgggtcc tcaggaactt tcattatcaa cagcacacag      540

gtgaactcca gaaagaagaa gctatggccg ccgtgatcct ggaatccatc ttcctgaagc      600

ggagccagca gaagaagaaa acaagccctc tgaacttcaa gaagcggctg ttcctgctga      660

ccgtgcacaa gctgagctac tacgagtacg acttcgagcg gggcagaaga ggcagcaaga      720

aaggcagcat cgacgtggaa aagatcacct gtgtggaaac cgtggtgccc gagaagaacc      780

ctccacctga gagacagatc cccagaaggg gcgaagagtc cagcgagatg gaacagatct      840

ctatcatcga gcggttcccg tatcctttcc aagtggtgta cgacgagggc ccactgtacg      900

tgttcagccc taccgaggaa ctgcggaaga gatggatcca ccagctgaag aacgtgatcc      960

ggtacaacag cgacctggtg cagaagtatc acccctgctt ttggatcgac ggccagtacc     1020

tgtgctgtag ccagaccgcc aagaatgcca tgggctgcca gattctggaa aaccggaacg     1080

gctctctgaa gcccggcagc agccacagaa agaccaagaa gcctctgcct cctacacctg     1140

aagaggacca gatcctgaag aaacccctgc ctccagaacc tgccgctgct cctgtgtcta     1200

ccagcgagct gaaaaaggtg gtggccctgt acgactacat gcccatgaac gccaacgacc     1260

tgcagctgag aaagggcgac gagtacttca tcctggaaga gtctaacctg ccttggtggc     1320

gggccagaga caagaatggc caagagggct acatccccag caactacgtg accgaggccg     1380

aggacagcat cgagatgtac gagtggtaca gcaagcacat gaccagaagc caggccgaac     1440

agctgctgaa gcaagagggc aaagaaggcg gcttcatcgt ccgggattct agcaaggccg     1500

gcaagtacac cgtgtccgtg ttcgccaaga gcaccggcga tcctcagggc gtgatcagac     1560

actacgtcgt gtgtagcacc cctcagagcc agtactacct ggccgagaag cacctgttca     1620

gcacaatccc cgagctgatc aactaccacc agcacaactc tgccggcctg atcagcagac     1680

tgaagtaccc tgtgtctcag cagaacaaaa acgcccctag cacagccggc ctcggctatg     1740

gatcttggga gatcgacccc aaggacctga ccttcctgaa agaactcggc accggccagt     1800

tcggcgtcgt gaagtatgga aaatggcggg gacagtacga cgtggccatc aagatgatca     1860

aagagggcag catgagcgag gacgagttca tcgaagaggc caaagtgatg atgaacctga     1920

gccacgagaa gctggtgcag ctgtacggcg tgtgtaccaa gcagcggccc atctttatca     1980

tcaccgagta catggccaac ggctgcctgc tgaactacct gcgcgaaatg cggcaccggt     2040

ttcagacaca gcaactgctg gaaatgtgca aggacgtgtg cgaggccatg gaatacctgg     2100

aaagcaagca gttcctgcac cgcgatctgg ccgccagaaa ctgcctggtc aatgatcagg     2160

gcgttgtgaa ggtgtccgac ttcggcctga gcagatacgt gctggacgat gagtacacca     2220

gcagcgtggg cagcaagttt cccgtcagat ggtccccacc tgaggtgctg atgtactcca     2280

agttcagctc caagagcgac atctgggcct tcggcgttct gatgtgggag atctacagcc     2340

tgggcaagat gccctacgag agattcacca acagcgagac agccgagcac attgcccagg     2400

gcctgagact gtatagacct cacctggcct ccgagaaggt gtacacaatc atgtacagct     2460

gttggcacga ggtaagtgct ttattaggat ctcttaaatt atttccttga atctacttgc     2520

ccatttagct ggccattcag ccaccaaaga ctgatagctg cacacattct tttttttcct     2580

tttttttttt ttttaatttg agacaaggtc tcgctctttc acccaggttg gagtacagtg     2640

gcgcgatctt ggcttactgc aaccttcgcc tcccagattc aagcgattct catgtctcag     2700

cctcccaagt agctgggatt ataggcgtgc accaccacac caagctaatt tttttttttt     2760

tttttggtga cacagtcttg ctctgtcacc cgttctgcca accacttgaa cttgtttggt     2820

agccattttt cacttgagga tccaaaataa gaatgtgttg tatacagtta cataatgaac     2880

ttgccctcaa ttttgatcag tgtgattgtc agtttaattt gcaaattgtt cttatcacac     2940

taataacctg agttactaaa gatgaaaagt gcacaaagac tttatggaga gctgctattt     3000

cttttttttt tttttttcct tttgtaatcg acagggcatg ctactgggca tagagcatat     3060

atttaataaa catttgctgc ttactcattg catttccctt gaattctgga ttctagccac     3120

tctaacactt tactttttct ttggttttag aaggccgacg agcggcctac ctttaagatc     3180

ctgctgagca acatcctgga cgtgatggac gaggaatccg gtggaggcgg tggagggtac     3240

ccatacgatg ttccagatta cgcttatccg tacgacgtcc cggattacgc ttatccctat     3300

gacgtgcctg attatgcttg agctcgccaa taagcttctt ggttctactt ctcttctcca     3360

caagccccaa tttcactttc tcagaggaaa tcccaagctt aggagccctg gagcctttgt     3420

gctcccactc aatacaaaaa ggcccctctc tacatctggg aatgcacctc ttctttgatt     3480

ccctgggata gtggcttctg agcaaaggcc aagaaattat tgtgcctgaa atttcccgag     3540

agaattaaga cagactgaat ttgcgatgaa aatatttttt aggagggagg atgtaaatag     3600

ccgcacaaag gggtccaaca gctctttgag taggcatttg gtagagcttg ggggtgtgtg     3660

tgtgggggtg gaccgaattt ggcaagaatg aaatggtgtc ataaagatgg gaggggaggg     3720

tgttttgata aaataaaatt actagaaagc attagatctg tgtgttggtt ttttgtgtgt     3780

cctgggtcct caggaacttt cattatcaac agcacacagg tgaactccag aaagaagaag     3840

ctatggccgc agtgattctg gagagcatct ttctgaagcg atcccaacag aaaaagaaaa     3900

catcacctct aaacttcaag aagcgcctgt ttctcttgac cgtgcacaaa ctctcctact     3960

atgagtatga ctttgaacgt ggggtaagtt tctcgactat gaaaactgag tttcaagata     4020

tcaaggactt ggccttagat ctttcttggg gaagaggtaa attttcgttg gtaggaggag     4080

gggagtagaa tggacctaag ttctttcaaa ttcagcaaaa tatttcctag cctataacta     4140

gctaaagccg gaaagtcaaa ggtcctaaga agccacaagg aaaatattac catggaatct     4200

tggaattgat gagcactcat taaatgattg ttgaaaatga aatcgaagag ttggaaattg     4260

cttccttact tcctatgag                                                  4279


<210>  8
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  8
tgcacaaact ctcctactat                                                   20


<210>  9
<211>  3443
<212>  DNA
<213>  Homo sapiens

<400>  9
acagatactt ttgcttttca cagattctac acatatcata taaaggtgaa tagtgtaaag       60

ctacctctac accttaccaa gcacacaggt gcgtgccatt taacatctag agcattccat      120

tgccttatac aagaactcag tttatatgag ctcacaacat cgaaccaatc cccccccaat      180

tcagtgtgca tccattatac ctgaaacctg acagagctgg gggctgtggg aggaggttgg      240

taggaagaaa ttattttgtg agctgtgcac atttttgttc catttgaaac taggtagcta      300

ggctgagggg gaaccaagag ggatgaggat taatgtcctg ggtcctcagg aactttcatt      360

atcaacagca cacaggtgaa ctccagaaag aagaagctat ggccgcagtg attctggaga      420

gcatctttct gaagcgatcc caacagaaaa agaaaacatc acctctaaac ttcaagaagc      480

gcctgtttct cttgaccgtg cacaagctga gctactacga gtacgacttc gagcggggca      540

gaagaggcag caagaaaggc agcatcgacg tggaaaagat cacctgtgtg gaaaccgtgg      600

tgcccgagaa gaaccctcca cctgagagac agatccccag aaggggcgaa gagtccagcg      660

agatggaaca gatctctatc atcgagcggt tcccgtatcc tttccaagtg gtgtacgacg      720

agggcccact gtacgtgttc agccctaccg aggaactgcg gaagagatgg atccaccagc      780

tgaagaacgt gatccggtac aacagcgacc tggtgcagaa gtatcacccc tgcttttgga      840

tcgacggcca gtacctgtgc tgtagccaga ccgccaagaa tgccatgggc tgccagattc      900

tggaaaaccg gaacggctct ctgaagcccg gcagcagcca cagaaagacc aagaagcctc      960

tgcctcctac acctgaagag gaccagatcc tgaagaaacc cctgcctcca gaacctgccg     1020

ctgctcctgt gtctaccagc gagctgaaaa aggtggtggc cctgtacgac tacatgccca     1080

tgaacgccaa cgacctgcag ctgagaaagg gcgacgagta cttcatcctg gaagagtcta     1140

acctgccttg gtggcgggcc agagacaaga atggccaaga gggctacatc cccagcaact     1200

acgtgaccga ggccgaggac agcatcgaga tgtacgagtg gtacagcaag cacatgacca     1260

gaagccaggc cgaacagctg ctgaagcaag agggcaaaga aggcggcttc atcgtccggg     1320

attctagcaa ggccggcaag tacaccgtgt ccgtgttcgc caagagcacc ggcgatcctc     1380

agggcgtgat cagacactac gtcgtgtgta gcacccctca gagccagtac tacctggccg     1440

agaagcacct gttcagcaca atccccgagc tgatcaacta ccaccagcac aactctgccg     1500

gcctgatcag cagactgaag taccctgtgt ctcagcagaa caaaaacgcc cctagcacag     1560

ccggcctcgg ctatggatct tgggagatcg accccaagga cctgaccttc ctgaaagaac     1620

tcggcaccgg ccagttcggc gtcgtgaagt atggaaaatg gcggggacag tacgacgtgg     1680

ccatcaagat gatcaaagag ggcagcatga gcgaggacga gttcatcgaa gaggccaaag     1740

tgatgatgaa cctgagccac gagaagctgg tgcagctgta cggcgtgtgt accaagcagc     1800

ggcccatctt tatcatcacc gagtacatgg ccaacggctg cctgctgaac tacctgcgcg     1860

aaatgcggca ccggtttcag acacagcaac tgctggaaat gtgcaaggac gtgtgcgagg     1920

ccatggaata cctggaaagc aagcagttcc tgcaccgcga tctggccgcc agaaactgcc     1980

tggtcaatga tcagggcgtt gtgaaggtgt ccgacttcgg cctgagcaga tacgtgctgg     2040

acgatgagta caccagcagc gtgggcagca agtttcccgt cagatggtcc ccacctgagg     2100

tgctgatgta ctccaagttc agctccaaga gcgacatctg ggccttcggc gttctgatgt     2160

gggagatcta cagcctgggc aagatgccct acgagagatt caccaacagc gagacagccg     2220

agcacattgc ccagggcctg agactgtata gacctcacct ggcctccgag aaggtgtaca     2280

caatcatgta cagctgttgg cacgagaagg ccgacgagcg gcctaccttt aagatcctgc     2340

tgagcaacat cctggacgtg atggacgagg aatccgccgc tgtgtacccc tacgatgtgc     2400

ctgattacgc cggctatcct tacgacgtgc cagactatgc cggcagctac ccctatgacg     2460

tccccgatta tgcccctgcc gcttaagctc gccaataagc ttcttggttc tacttctctt     2520

ctccacaagc cccaatttca ctttctcaga ggaaatccca agcttaggag ccctggagcc     2580

tttgtgctcc cactcaatac aaaaaggccc ctctctacat ctgggaatgc acctcttctt     2640

tgattccctg ggatagtggc ttctgagcaa aggccaagaa attattgtgc ctgaaatttc     2700

ccgagagaat taagacagac tgaatttgcg atgaaaatat tttttaggag ggaggatgta     2760

aatagccgca caaaggggtc caacagctct ttgagtaggc atttggtaga gcttgggggt     2820

gtgtgtgtgg gggtggaccg aatttggcaa gaatgaaatg gtgtcataaa gatgggaggg     2880

gagggtgttt tgataaaata aaattactag aaagcattag atctgtgtgt tggttttttg     2940

tgtgacaaac tctcctacta tgagtatgac tttgaacgtg gggtaagttt ctcgactatg     3000

aaaactgagt ttcaagatat caaggacttg gccttagatc tttcttgggg aagaggtaaa     3060

ttttcgttgg taggaggagg ggagtagaat ggacctaagt tctttcaaat tcagcaaaat     3120

atttcctagc ctataactag ctaaagccgg aaagtcaaag gtcctaagaa gccacaagga     3180

aaatattacc atggaatctt ggaattgatg agcactcatt aaatgattgt tgaaaatgaa     3240

atcgaagagt tggaaattgc ttccttactt cctatgagga aggtacatac agtcattcac     3300

tcttccatgg tatttgccct ccatttggta gtcatagatt tatagatctg gaaggatttt     3360

tttttcttcc cccacatgac aggtcctggt gccacctcac tttgttgaat gattagataa     3420

caaaatctaa tcatctggtt gct                                             3443


<210>  10
<211>  5
<212>  DNA
<213>  S. thermophilius


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is a, c, g, or t

<400>  10
nggng                                                                    5


<210>  11
<211>  6
<212>  DNA
<213>  S. thermophilius


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is a, c, g, or t

<400>  11
nnaaaw                                                                   6


<210>  12
<211>  6
<212>  DNA
<213>  S. thermophilius


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is a, c, g, or t

<400>  12
nnagaa                                                                   6


<210>  13
<211>  7
<212>  DNA
<213>  S. thermophilius


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  n is a, c, g, or t

<400>  13
nnngatt                                                                  7


<210>  14
<211>  7
<212>  DNA
<213>  C. jejuni


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  n is a, c, g, or t

<400>  14
nnnnaca                                                                  7


<210>  15
<211>  8
<212>  DNA
<213>  N. meningitides


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  n is a, c, g, or t

<400>  15
nnnngatt                                                                 8


<210>  16
<211>  8
<212>  DNA
<213>  P. multocida


<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  n is a, c, g, or t

<400>  16
gnnncnna                                                                 8


<210>  17
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Suitable target sequence for use with a S. pyogenes CRISPR/Cas 
       system


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is present or absent

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is present or absent

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is present or absent

<220>
<221>  misc_feature
<222>  (4)..(20)
<223>  n is a, c, g, or t

<400>  17
nnnnnnnnnn nnnnnnnnnn rg                                                22


<210>  18
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Suitable target sequence for use with a S. pyogenes CRISPR/Cas 
       system


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is present or absent

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is present or absent

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is present or absent

<220>
<221>  misc_feature
<222>  (5)..(21)
<223>  n is a, c, g, or t

<400>  18
gnnnnnnnnn nnnnnnnnnn nrg                                               23


<210>  19
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR/Cas guide RNA

<400>  19
aauuucuacu guuguagau                                                    19


<210>  20
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR/Cas guide RNA

<400>  20
aauuucugcu guugcagau                                                    19


<210>  21
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR/Cas guide RNA

<400>  21
aauuuccacu guuguggau                                                    19


<210>  22
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR/Cas guide RNA

<400>  22
aauuccuacu guuguaggu                                                    19


<210>  23
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR/Cas guide RNA

<400>  23
aauuucuacu auuguagau                                                    19


<210>  24
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR/Cas guide RNA

<400>  24
aauuucuacu gcuguagau                                                    19


<210>  25
<211>  18
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR/Cas guide RNA

<400>  25
aauuucuacu uuguagau                                                     18


<210>  26
<211>  17
<212>  RNA
<213>  Artificial

<220>
<223>  CRISPR/Cas guide RNA

<400>  26
aauuucuacu uguagau                                                      17


<210>  27
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Nuclear localization signal

<400>  27

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  28
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Nuclear localization signal

<400>  28

Pro Lys Lys Lys Arg Arg Val 
1               5           


<210>  29
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Nuclear localization signal

<400>  29

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  30
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide sequence

<400>  30

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln Pro Lys Lys 
1               5                   10                  15      


Lys Arg Lys Val 
            20  


<210>  31
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide sequence

<400>  31

Pro Leu Ser Ser Ile Phe Ser Arg Ile Gly Asp Pro Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val 
            


<210>  32
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide sequence

<400>  32

Gly Ala Leu Phe Leu Gly Trp Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Pro Lys Lys Lys Arg Lys Val 
            20                  


<210>  33
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide sequence

<400>  33

Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210>  34
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide sequence

<400>  34

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


