                         SEQUENCE LISTING

<110>  Purdue Research Foundation
 
<120>  Targeting Anabolics for Accelerated Fracture Repair

<130>  68304-03-WO

<150>  62/678,016
<151>  2018-05-30

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BFP D10

<400>  1

Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Gly Gln Gly Phe Ser Tyr 
1               5                   10                  15      


Pro Tyr Lys Ala Val Phe Ser Thr Gln 
            20                  25  


<210>  2
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OGP D10

<400>  2

Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Ala Leu Lys Arg Gln Gly 
1               5                   10                  15      


Arg Thr Leu Tyr Gly Phe Gly Gly 
            20                  


<210>  3
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Preptin D10

<400>  3

His Asp Val Ser Thr Ser Gln Ala Val Leu Pro Asp Asp Phe Pro Arg 
1               5                   10                  15      


Tyr Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp 
            20                  25          


<210>  4
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  substance P 4 mini PEG D10 with


<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  4 mini PEG linker

<400>  4

Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Arg Pro Lys Pro Gln Gln 
1               5                   10                  15      


Phe Phe Gly Leu Met 
            20      


<210>  5
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ghrelin D10 with Ser-3 replacement


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Ser-3 modified with diaminopropionic acid

<400>  5

His Gly Ser Phe Leu Ser Pro Glu His Gln Lys Ala Gln Gln Arg Lys 
1               5                   10                  15      


Glu Ser Lys Lys Pro Pro Ala Lys Leu Gln Pro Arg Asp Asp Asp Asp 
            20                  25                  30          


Asp Asp Asp Asp Asp Asp 
        35              


<210>  6
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BMP9-D10


<220>
<221>  MOD_RES
<222>  (23)..(24)
<223>  4 MINI PEG LINKER

<400>  6

Cys Gly Gly Lys Val Gly Lys Ala Cys Cys Val Pro Thr Lys Leu Ser 
1               5                   10                  15      


Pro Ile Ser Val Leu Tyr Lys Asp Asp Asp Asp Asp Asp Asp Asp Asp 
            20                  25                  30          


Asp 
    


<210>  7
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP D10


<220>
<221>  DISULFID
<222>  (17)..(33)

<400>  7

His Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Gly Leu Ser Lys Gly 
1               5                   10                  15      


Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly 
            20                  25                  30          


Cys 
    


<210>  8
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Vasoactive intestinal peptide with D10 (VIP D10)

<400>  8

His His Ser Asp Ala Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys 
1               5                   10                  15      


Gln Met Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn Asp Asp Asp 
            20                  25                  30          


Asp Asp Asp Asp Asp Asp Asp 
        35                  


<210>  9
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CBM D10

<400>  9

His Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Gly Leu Arg Ser Lys 
1               5                   10                  15      


Ser Lys Lys Phe Arg Arg Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp 
            20                  25                  30          


Glu Asp Ile Thr Ser His Met 
        35                  


<210>  10
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P4 D10-a BMP2 fragment

<400>  10

His Lys Ile Pro Lys Ala Ser Ser Val Pro Thr Glu Leu Ser Ala Ile 
1               5                   10                  15      


Ser Thr Leu Tyr Leu Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp 
            20                  25                  30      


<210>  11
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mechano-growth factor (MGF) D10, an IGF-I fragment

<400>  11

Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Tyr Gln Pro Pro Ser Thr 
1               5                   10                  15      


Asn Lys Asn Thr Lys Ser Gln Arg Arg Lys Gly Ser Thr Phe Glu Glu 
            20                  25                  30          


His Lys 
        


<210>  12
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TP 508_D10

<400>  12

Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Ala Gly Tyr Lys Pro Asp 
1               5                   10                  15      


Glu Gly Lys Arg Gly Asp Ala Cys Glu Gly Asp Ser Gly Gly Pro Phe 
            20                  25                  30          


Val 
    


<210>  13
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ODP-D10


<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  4 mini PEG linker

<400>  13

Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Val Asp Val Pro Asp 
1               5                   10                  15      


Gly Arg Gly Asp Ser Leu Ala Tyr Gly 
            20                  25  


<210>  14
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BMP9


<220>
<221>  MISC_FEATURE
<222>  (21)..(22)

<400>  14

Gly Gly Lys Val Gly Lys Ala Cys Cys Val Pro Thr Lys Leu Ser Pro 
1               5                   10                  15      


Ile Ser Val Leu Tyr Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp 
            20                  25                  30      


<210>  15
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ghrelin D10

<400>  15

Phe Leu Ser Pro Glu His Gln Lys Ala Gln Gln Arg Lys Glu Ser Lys 
1               5                   10                  15      


Lys Pro Pro Ala Lys Leu Gln Pro Arg Asp Asp Asp Asp Asp Asp Asp 
            20                  25                  30          


Asp Asp Asp 
        35  


<210>  16
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNP-D10.


<220>
<221>  MISC_FEATURE
<222>  (15)..(16)

<400>  16

Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Gly Leu Ser Lys Gly Phe 
1               5                   10                  15      


Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly 
            20                  25                  30  


<210>  17
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VIP D10

<400>  17

His His Ser Asp Ala Val Phe Thr Asp Asn Tyr Thr Arg Leu Thr Lys 
1               5                   10                  15      


Gln Met Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn Asp Asp Asp 
            20                  25                  30          


Asp Asp Asp Asp Asp Asp Asp 
        35                  


<210>  18
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4 mini PEG D10

<400>  18

His Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp 
1               5                   10      


<210>  19
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ODPD10


<220>
<221>  MISC_FEATURE
<222>  (4)..(5)

<220>
<221>  MISC_FEATURE
<222>  (16)..(17)

<400>  19

His Ala Ile Ser Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys 
1               5                   10                  15      


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            20                  25      


<210>  20
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PACAP-(D)E10


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)

<220>
<221>  MISC_FEATURE
<222>  (6)..(7)

<400>  20

Lys Asn Thr Ala Thr Ala Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp 
1               5                   10                  15      


<210>  21
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amylin 1-8


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)

<220>
<221>  MISC_FEATURE
<222>  (6)..(7)

<220>
<221>  MISC_FEATURE
<222>  (36)..(37)

<400>  21

His Ser Asn Thr Ala Thr Val Thr His Arg Leu Ala Gly Leu Leu Ser 
1               5                   10                  15      


Arg Ser Gly Gly Val Val Lys Asp Asn Phe Val Pro Thr Asn Val Gly 
            20                  25                  30          


Ser Glu Ala Phe Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
        35                  40                  45      


<210>  22
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CGRP-E10

<400>  22

His His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys 
1               5                   10                  15      


Gln Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr 
            20                  25                  30          


Lys Gln Arg Val Lys Asn Lys Glu Glu Glu Glu Glu Glu Glu Glu Glu 
        35                  40                  45              


Glu 
    


