                         SEQUENCE LISTING

<110>  University of Pittsburgh - Of the Commonwealth System of 
       Higher Education
       University of Pennsylvania
 
<120>  Antigencially stealthed oncolytic viruses

<130>  6527-1902486

<150>  US 62/678,737
<151>  2013-05-31

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  369
<212>  PRT
<213>  herpes simplex virus

<400>  1

Lys Tyr Ala Leu Ala Asp Ala Ser Leu Lys Met Ala Asp Pro Asn Arg 
1               5                   10                  15      


Phe Arg Gly Lys Asp Leu Pro Val Leu Asp Gln Leu Thr Asp Pro Pro 
            20                  25                  30          


Gly Val Arg Arg Val Tyr His Ile Gln Ala Gly Leu Pro Asp Pro Phe 
        35                  40                  45              


Gln Pro Pro Ser Leu Pro Ile Thr Val Tyr Tyr Ala Val Leu Glu Arg 
    50                  55                  60                  


Ala Cys Arg Ser Val Leu Leu Asn Ala Pro Ser Glu Ala Pro Gln Ile 
65                  70                  75                  80  


Val Arg Gly Ala Ser Glu Asp Val Arg Lys Gln Pro Tyr Asn Leu Thr 
                85                  90                  95      


Ile Ala Trp Phe Arg Met Gly Gly Asn Cys Ala Ile Pro Ile Thr Val 
            100                 105                 110         


Met Glu Tyr Thr Glu Cys Ser Tyr Asn Lys Ser Leu Gly Ala Cys Pro 
        115                 120                 125             


Ile Arg Thr Gln Pro Arg Trp Asn Tyr Tyr Asp Ser Phe Ser Ala Val 
    130                 135                 140                 


Ser Glu Asp Asn Leu Gly Phe Leu Met His Ala Pro Ala Phe Glu Thr 
145                 150                 155                 160 


Ala Gly Thr Tyr Leu Arg Leu Val Lys Ile Asn Asp Trp Thr Glu Ile 
                165                 170                 175     


Thr Gln Phe Ile Leu Glu His Arg Ala Lys Gly Ser Cys Lys Tyr Ala 
            180                 185                 190         


Leu Pro Leu Arg Ile Pro Pro Ser Ala Cys Leu Ser Pro Gln Ala Tyr 
        195                 200                 205             


Gln Gln Gly Val Thr Val Asp Ser Ile Gly Met Leu Pro Arg Phe Ile 
    210                 215                 220                 


Pro Glu Asn Gln Arg Thr Val Ala Val Tyr Ser Leu Lys Ile Ala Gly 
225                 230                 235                 240 


Trp His Gly Pro Lys Ala Pro Tyr Thr Ser Thr Leu Leu Pro Pro Glu 
                245                 250                 255     


Leu Ser Glu Thr Pro Asn Ala Thr Gln Pro Glu Leu Ala Pro Glu Asp 
            260                 265                 270         


Pro Glu Asp Ser Ala Leu Leu Glu Asp Pro Val Gly Thr Val Ala Pro 
        275                 280                 285             


Gln Ile Pro Pro Asn Trp His Ile Pro Ser Ile Gln Asp Ala Ala Thr 
    290                 295                 300                 


Pro Tyr His Pro Pro Ala Thr Pro Asn Asn Met Gly Leu Ile Ala Gly 
305                 310                 315                 320 


Ala Val Gly Gly Ser Leu Leu Ala Ala Leu Val Ile Cys Gly Ile Val 
                325                 330                 335     


Tyr Trp Met His Arg Arg Thr Arg Lys Ala Pro Lys Arg Ile Arg Leu 
            340                 345                 350         


Pro His Ile Arg Glu Asp Asp Gln Pro Ser Ser His Gln Pro Leu Phe 
        355                 360                 365             


Tyr 
    


<210>  2
<211>  368
<212>  PRT
<213>  herpes simplex virus

<400>  2

Lys Tyr Ala Leu Ala Asp Pro Ser Leu Lys Met Ala Asp Pro Asn Arg 
1               5                   10                  15      


Phe Arg Gly Lys Asn Leu Pro Val Leu Asp Gln Leu Thr Asp Pro Pro 
            20                  25                  30          


Gly Val Lys Arg Val Tyr His Ile Gln Pro Ser Leu Glu Asp Pro Phe 
        35                  40                  45              


Gln Pro Pro Ser Ile Pro Ile Thr Val Tyr Tyr Ala Val Leu Glu Arg 
    50                  55                  60                  


Ala Cys Arg Ser Val Leu Leu His Ala Pro Ser Glu Ala Pro Gln Ile 
65                  70                  75                  80  


Val Arg Gly Ala Ser Asp Glu Ala Arg Lys His Thr Tyr Asn Leu Thr 
                85                  90                  95      


Ile Ala Trp Tyr Arg Met Gly Asp Asn Cys Ala Ile Pro Ile Thr Val 
            100                 105                 110         


Met Glu Tyr Thr Glu Cys Pro Tyr Asn Lys Ser Leu Gly Val Cys Pro 
        115                 120                 125             


Ile Arg Thr Gln Pro Arg Trp Ser Tyr Tyr Asp Ser Phe Ser Ala Val 
    130                 135                 140                 


Ser Glu Asp Asn Leu Gly Phe Leu Met His Ala Pro Ala Phe Glu Thr 
145                 150                 155                 160 


Ala Gly Thr Tyr Leu Arg Leu Val Lys Ile Asn Asp Trp Thr Glu Ile 
                165                 170                 175     


Thr Gln Phe Ile Leu Glu His Arg Ala Arg Ala Ser Cys Lys Tyr Ala 
            180                 185                 190         


Leu Pro Leu Arg Ile Pro Pro Ala Ala Cys Leu Thr Ser Lys Ala Tyr 
        195                 200                 205             


Gln Gln Gly Val Thr Val Asp Ser Ile Gly Met Leu Pro Arg Phe Ile 
    210                 215                 220                 


Pro Glu Asn Gln Arg Thr Val Ala Leu Tyr Ser Leu Lys Ile Ala Gly 
225                 230                 235                 240 


Trp His Gly Pro Lys Pro Pro Tyr Thr Ser Thr Leu Leu Pro Pro Glu 
                245                 250                 255     


Leu Ser Asp Thr Thr Asn Ala Thr Gln Pro Glu Leu Val Pro Glu Asp 
            260                 265                 270         


Pro Glu Asp Ser Ala Leu Leu Glu Asp Pro Ala Gly Thr Val Ser Ser 
        275                 280                 285             


Gln Ile Pro Pro Asn Trp His Ile Pro Ser Ile Gln Asp Val Ala Pro 
    290                 295                 300                 


His His Ala Pro Ala Ala Pro Ser Asn Pro Gly Leu Ile Ile Gly Ala 
305                 310                 315                 320 


Leu Ala Gly Ser Thr Leu Ala Val Leu Val Ile Gly Gly Ile Ala Phe 
                325                 330                 335     


Trp Val Arg Arg Arg Ala Gln Met Ala Pro Lys Arg Leu Arg Leu Pro 
            340                 345                 350         


His Ile Arg Asp Asp Asp Ala Pro Pro Ser His Gln Pro Leu Phe Tyr 
        355                 360                 365             


<210>  3
<211>  904
<212>  PRT
<213>  herpes simplex virus

<400>  3

Met His Gln Gly Ala Pro Ser Trp Gly Arg Arg Trp Phe Val Val Trp 
1               5                   10                  15      


Ala Leu Leu Gly Leu Thr Leu Gly Val Leu Val Ala Ser Ala Ala Pro 
            20                  25                  30          


Thr Ser Pro Gly Thr Pro Gly Val Ala Ala Ala Thr Gln Ala Ala Asn 
        35                  40                  45              


Gly Gly Pro Ala Thr Pro Ala Pro Pro Pro Leu Gly Ala Ala Pro Thr 
    50                  55                  60                  


Gly Asp Pro Lys Pro Lys Lys Asn Lys Lys Pro Lys Asn Pro Thr Pro 
65                  70                  75                  80  


Pro Arg Pro Ala Gly Asp Asn Ala Thr Val Ala Ala Gly His Ala Thr 
                85                  90                  95      


Leu Arg Glu His Leu Arg Asp Ile Lys Ala Glu Asn Thr Asp Ala Asn 
            100                 105                 110         


Phe Tyr Val Cys Pro Pro Pro Thr Gly Ala Thr Val Val Gln Phe Glu 
        115                 120                 125             


Gln Pro Arg Arg Cys Pro Thr Arg Pro Glu Gly Gln Asn Tyr Thr Glu 
    130                 135                 140                 


Gly Ile Ala Val Val Phe Lys Glu Asn Ile Ala Pro Tyr Lys Phe Lys 
145                 150                 155                 160 


Ala Thr Met Tyr Tyr Lys Asp Val Thr Val Ser Gln Val Trp Phe Gly 
                165                 170                 175     


His Arg Tyr Ser Gln Phe Met Gly Ile Phe Glu Asp Arg Ala Pro Val 
            180                 185                 190         


Pro Phe Glu Glu Val Ile Asp Lys Ile Asn Ala Lys Gly Val Cys Arg 
        195                 200                 205             


Ser Thr Ala Lys Tyr Val Arg Asn Asn Leu Glu Thr Thr Ala Phe His 
    210                 215                 220                 


Arg Asp Asp His Glu Thr Asp Met Glu Leu Lys Pro Ala Asn Ala Ala 
225                 230                 235                 240 


Thr Arg Thr Ser Arg Gly Trp His Thr Thr Asp Leu Lys Tyr Asn Pro 
                245                 250                 255     


Ser Arg Val Glu Ala Phe His Arg Tyr Gly Thr Thr Val Asn Cys Ile 
            260                 265                 270         


Val Glu Glu Val Asp Ala Arg Ser Val Tyr Pro Tyr Asp Glu Phe Val 
        275                 280                 285             


Leu Ala Thr Gly Asp Phe Val Tyr Met Ser Pro Phe Tyr Gly Tyr Arg 
    290                 295                 300                 


Glu Gly Ser His Thr Glu His Thr Thr Tyr Ala Ala Asp Arg Phe Lys 
305                 310                 315                 320 


Gln Val Asp Gly Phe Tyr Ala Arg Asp Leu Thr Thr Lys Ala Arg Ala 
                325                 330                 335     


Thr Ala Pro Thr Thr Arg Asn Leu Leu Thr Thr Pro Lys Phe Thr Val 
            340                 345                 350         


Ala Trp Asp Trp Val Pro Lys Arg Pro Ser Val Cys Thr Met Thr Lys 
        355                 360                 365             


Trp Gln Glu Val Asp Glu Met Leu Arg Ser Glu Tyr Gly Gly Ser Phe 
    370                 375                 380                 


Arg Phe Ser Ser Asp Ala Ile Ser Thr Thr Phe Thr Thr Asn Leu Thr 
385                 390                 395                 400 


Glu Tyr Pro Leu Ser Arg Val Asp Leu Gly Asp Cys Ile Gly Lys Asp 
                405                 410                 415     


Ala Arg Asp Ala Met Asp Arg Ile Phe Ala Arg Arg Tyr Asn Ala Thr 
            420                 425                 430         


His Ile Lys Val Gly Gln Pro Gln Tyr Tyr Gln Ala Asn Gly Gly Phe 
        435                 440                 445             


Leu Ile Ala Tyr Gln Pro Leu Leu Ser Asn Thr Leu Ala Glu Leu Tyr 
    450                 455                 460                 


Val Arg Glu His Leu Arg Glu Gln Ser Arg Lys Pro Pro Asn Pro Thr 
465                 470                 475                 480 


Pro Pro Pro Pro Gly Ala Ser Ala Asn Ala Ser Val Glu Arg Ile Lys 
                485                 490                 495     


Thr Thr Ser Ser Ile Glu Phe Ala Arg Leu Gln Phe Thr Tyr Asn His 
            500                 505                 510         


Ile Gln Arg His Val Asn Asp Met Leu Gly Arg Val Ala Ile Ala Trp 
        515                 520                 525             


Cys Glu Leu Gln Asn His Glu Leu Thr Leu Trp Asn Glu Ala Arg Lys 
    530                 535                 540                 


Leu Asn Pro Asn Ala Ile Ala Ser Val Thr Val Gly Arg Arg Val Ser 
545                 550                 555                 560 


Ala Arg Met Leu Gly Asp Val Met Ala Val Ser Thr Cys Val Pro Val 
                565                 570                 575     


Ala Ala Asp Asn Val Ile Val Gln Asn Ser Met Arg Ile Ser Ser Arg 
            580                 585                 590         


Pro Gly Ala Cys Tyr Ser Arg Pro Leu Val Ser Phe Arg Tyr Glu Asp 
        595                 600                 605             


Gln Gly Pro Leu Val Glu Gly Gln Leu Gly Glu Asn Asn Glu Leu Arg 
    610                 615                 620                 


Leu Thr Arg Asp Ala Ile Glu Pro Cys Thr Val Gly His Arg Arg Tyr 
625                 630                 635                 640 


Phe Thr Phe Gly Gly Gly Tyr Val Tyr Phe Glu Glu Tyr Ala Tyr Ser 
                645                 650                 655     


His Gln Leu Ser Arg Ala Asp Ile Thr Thr Val Ser Thr Phe Ile Asp 
            660                 665                 670         


Leu Asn Ile Thr Met Leu Glu Asp His Glu Phe Val Pro Leu Glu Val 
        675                 680                 685             


Tyr Thr Arg His Glu Ile Lys Asp Ser Gly Leu Leu Asp Tyr Thr Glu 
    690                 695                 700                 


Val Gln Arg Arg Asn Gln Leu His Asp Leu Arg Phe Ala Asp Ile Asp 
705                 710                 715                 720 


Thr Val Ile His Ala Asp Ala Asn Ala Ala Met Phe Ala Gly Leu Gly 
                725                 730                 735     


Ala Phe Phe Glu Gly Met Gly Asp Leu Gly Arg Ala Val Gly Lys Val 
            740                 745                 750         


Val Met Gly Ile Val Gly Gly Val Val Ser Ala Val Ser Gly Val Ser 
        755                 760                 765             


Ser Phe Met Ser Asn Pro Phe Gly Ala Leu Ala Val Gly Leu Leu Val 
    770                 775                 780                 


Leu Ala Gly Leu Ala Ala Ala Phe Phe Ala Phe Arg Tyr Val Met Arg 
785                 790                 795                 800 


Leu Gln Ser Asn Pro Met Lys Ala Leu Tyr Pro Leu Thr Thr Lys Glu 
                805                 810                 815     


Leu Lys Asn Pro Thr Asn Pro Asp Ala Ser Gly Glu Gly Glu Glu Gly 
            820                 825                 830         


Gly Asp Phe Asp Glu Ala Lys Leu Ala Glu Ala Arg Glu Met Ile Arg 
        835                 840                 845             


Tyr Met Ala Leu Val Ser Ala Met Glu Arg Thr Glu His Lys Ala Lys 
    850                 855                 860                 


Lys Lys Gly Thr Ser Ala Leu Leu Ser Ala Lys Val Thr Asp Met Val 
865                 870                 875                 880 


Met Arg Lys Arg Arg Asn Thr Asn Tyr Thr Gln Val Pro Asn Lys Asp 
                885                 890                 895     


Gly Asp Ala Asp Glu Asp Asp Leu 
            900                 


<210>  4
<211>  902
<212>  PRT
<213>  herpes simplex virus

<400>  4

Met Arg Gly Gly Gly Leu Ile Cys Ala Leu Val Val Gly Ala Leu Val 
1               5                   10                  15      


Ala Ala Val Ala Ser Ala Ala Pro Ala Ala Pro Ala Ala Pro Arg Ala 
            20                  25                  30          


Ser Gly Ala Trp Pro Thr Val Ala Asn Gly Gly Pro Ala Ser Arg Pro 
        35                  40                  45              


Pro Pro Val Pro Ser Pro Ala Thr Thr Lys Ala Arg Lys Arg Lys Thr 
    50                  55                  60                  


Lys Lys Pro Pro Lys Arg Pro Glu Ala Thr Pro Pro Pro Asp Ala Asn 
65                  70                  75                  80  


Ala Thr Val Ala Ala Gly His Ala Thr Leu Arg Ala His Leu Arg Glu 
                85                  90                  95      


Ile Lys Val Glu Asn Ala Asp Ala Gln Phe Tyr Val Cys Pro Pro Pro 
            100                 105                 110         


Thr Gly Ala Thr Val Val Gln Phe Glu Gln Pro Arg Arg Cys Pro Thr 
        115                 120                 125             


Arg Pro Glu Gly Gln Asn Tyr Thr Glu Gly Ile Ala Val Val Phe Lys 
    130                 135                 140                 


Glu Asn Ile Ala Pro Tyr Lys Phe Lys Ala Thr Met Tyr Tyr Lys Asp 
145                 150                 155                 160 


Val Thr Val Ser Gln Val Trp Phe Gly His Arg Tyr Ser Gln Phe Met 
                165                 170                 175     


Gly Ile Phe Glu Asp Arg Ala Pro Val Pro Phe Glu Glu Val Ile Asp 
            180                 185                 190         


Lys Ile Asn Ala Lys Gly Val Cys Arg Ser Thr Ala Lys Tyr Val Arg 
        195                 200                 205             


Asn Asn Met Glu Thr Thr Ala Phe His Arg Asp Asp His Glu Thr Asp 
    210                 215                 220                 


Met Glu Leu Lys Pro Ala Lys Val Ala Thr Arg Thr Ser Arg Gly Trp 
225                 230                 235                 240 


His Thr Thr Asp Leu Lys Tyr Asn Pro Ser Arg Val Glu Ala Phe His 
                245                 250                 255     


Arg Tyr Gly Thr Thr Val Asn Cys Ile Val Glu Glu Val Asp Ala Arg 
            260                 265                 270         


Ser Val Tyr Pro Tyr Asp Glu Phe Val Leu Ala Thr Gly Asp Phe Val 
        275                 280                 285             


Tyr Met Ser Pro Phe Tyr Gly Tyr Arg Glu Gly Ser His Thr Glu His 
    290                 295                 300                 


Thr Thr Tyr Ala Ala Asp Arg Phe Lys Gln Val Asp Gly Phe Tyr Ala 
305                 310                 315                 320 


Arg Asp Leu Thr Thr Lys Ala Arg Ala Thr Ser Pro Thr Thr Arg Asn 
                325                 330                 335     


Leu Leu Thr Thr Pro Lys Phe Thr Val Ala Trp Asp Trp Val Pro Lys 
            340                 345                 350         


Arg Pro Ala Val Cys Thr Met Thr Lys Trp Gln Glu Val Asp Glu Met 
        355                 360                 365             


Leu Arg Ala Glu Tyr Gly Gly Ser Phe Arg Phe Ser Ser Asp Ala Ile 
    370                 375                 380                 


Ser Thr Thr Phe Thr Thr Asn Leu Thr Gln Tyr Ser Leu Ser Arg Val 
385                 390                 395                 400 


Asp Leu Gly Asp Cys Ile Gly Arg Asp Ala Arg Glu Ala Ile Asp Arg 
                405                 410                 415     


Met Phe Ala Arg Lys Tyr Asn Ala Thr His Ile Lys Val Gly Gln Pro 
            420                 425                 430         


Gln Tyr Tyr Leu Ala Thr Gly Gly Phe Leu Ile Ala Tyr Gln Pro Leu 
        435                 440                 445             


Leu Ser Asn Thr Leu Ala Glu Leu Tyr Val Arg Glu Tyr Met Arg Glu 
    450                 455                 460                 


Gln Asp Arg Lys Pro Arg Asn Ala Thr Pro Ala Pro Leu Arg Glu Arg 
465                 470                 475                 480 


Pro Ser Ala Asn Ala Ser Val Glu Arg Ile Lys Thr Thr Ser Ser Ile 
                485                 490                 495     


Glu Phe Ala Arg Leu Gln Phe Thr Tyr Asn His Ile Gln Arg His Val 
            500                 505                 510         


Asn Asp Met Leu Gly Arg Ile Ala Val Ala Trp Cys Glu Leu Gln Asn 
        515                 520                 525             


His Glu Leu Thr Leu Trp Asn Glu Ala Arg Lys Leu Asn Pro Asn Ala 
    530                 535                 540                 


Ile Ala Ser Ala Thr Val Gly Arg Arg Val Ser Ala Arg Met Leu Gly 
545                 550                 555                 560 


Asp Val Met Ala Val Ser Thr Cys Val Pro Val Ala Pro Asp Asn Val 
                565                 570                 575     


Ile Val Gln Asn Ser Met Arg Val Ser Ser Arg Pro Gly Thr Cys Tyr 
            580                 585                 590         


Ser Arg Pro Leu Val Ser Phe Arg Tyr Glu Asp Gln Gly Pro Leu Met 
        595                 600                 605             


Glu Gly Gln Leu Gly Glu Asn Asn Glu Leu Arg Leu Thr Arg Asp Ala 
    610                 615                 620                 


Leu Glu Pro Cys Thr Val Gly His Arg Arg Tyr Phe Ile Phe Gly Gly 
625                 630                 635                 640 


Gly Tyr Val Tyr Phe Glu Glu Tyr Ala Tyr Ser His Gln Leu Ser Arg 
                645                 650                 655     


Ala Asp Val Thr Thr Val Arg Thr Phe Ile Asp Leu Asn Ile Thr Met 
            660                 665                 670         


Leu Glu Asp His Glu Phe Val Pro Leu Glu Val Tyr Thr Arg His Glu 
        675                 680                 685             


Ile Lys Asp Ser Gly Leu Leu Asp Tyr Thr Glu Val Gln Arg Arg Asn 
    690                 695                 700                 


Gln Leu His Asp Leu Arg Phe Ala Asp Ile Asp Thr Val Ile Arg Ala 
705                 710                 715                 720 


Asp Ala Asn Ala Ala Met Phe Ala Gly Leu Cys Ala Phe Phe Glu Gly 
                725                 730                 735     


Met Gly Asp Leu Gly Arg Ala Val Gly Lys Val Val Met Gly Val Val 
            740                 745                 750         


Gly Gly Val Val Ser Ala Val Ser Gly Val Ser Ser Phe Met Ser Asn 
        755                 760                 765             


Pro Phe Gly Ala Leu Ala Val Gly Leu Leu Val Leu Ala Gly Leu Val 
    770                 775                 780                 


Ala Ala Phe Phe Ala Phe Arg Tyr Val Leu Gln Leu Gln Arg Asn Pro 
785                 790                 795                 800 


Met Lys Ala Leu Tyr Pro Leu Thr Thr Lys Glu Leu Lys Thr Ser Asp 
                805                 810                 815     


Pro Gly Gly Val Gly Gly Glu Gly Glu Glu Gly Ala Glu Gly Gly Gly 
            820                 825                 830         


Phe Asp Glu Ala Lys Leu Ala Glu Ala Arg Glu Met Ile Arg Tyr Met 
        835                 840                 845             


Ala Leu Val Ser Ala Met Glu Arg Thr Glu His Lys Ala Arg Lys Lys 
    850                 855                 860                 


Gly Thr Ser Ala Leu Leu Ser Ser Lys Val Thr Asn Met Val Leu Arg 
865                 870                 875                 880 


Lys Arg Asn Lys Ala Arg Tyr Ser Pro Leu His Asn Glu Asp Glu Ala 
                885                 890                 895     


Gly Asp Glu Asp Glu Leu 
            900         


<210>  5
<211>  625
<212>  PRT
<213>  herpes simplex virus

<400>  5

Met Gly Gly Ala Ala Ala Arg Leu Gly Ala Val Ile Leu Phe Val Val 
1               5                   10                  15      


Ile Val Gly Leu His Gly Val Arg Ser Lys Asp Ile Leu Met Thr Gln 
            20                  25                  30          


Ser Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser 
        35                  40                  45              


Cys Arg Ser Ser Gln Asn Ile Val His Asn Asn Gly Ile Thr Tyr Leu 
    50                  55                  60                  


Glu Trp Tyr Leu Gln Arg Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


Lys Val Ser Asp Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu 
            100                 105                 110         


Asp Leu Gly Ile Tyr Tyr Cys Phe Gln Gly Ser His Ile Pro Pro Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
145                 150                 155                 160 


Gln Gln Ser Gly Ser Glu Met Ala Arg Pro Gly Ala Ser Val Lys Leu 
                165                 170                 175     


Pro Cys Lys Ala Ser Gly Asp Thr Phe Thr Ser Tyr Trp Met His Trp 
            180                 185                 190         


Val Lys Gln Arg His Gly His Gly Pro Glu Trp Ile Gly Asn Ile Tyr 
        195                 200                 205             


Pro Gly Ser Gly Gly Thr Asn Tyr Ala Glu Lys Phe Lys Asn Lys Val 
    210                 215                 220                 


Thr Leu Thr Val Asp Arg Ser Ser Arg Thr Val Tyr Met His Leu Ser 
225                 230                 235                 240 


Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Thr Arg Ser Gly 
                245                 250                 255     


Gly Pro Tyr Phe Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            260                 265                 270         


Ser Ser Gly Gly Gly Gly Ser Gly Ser Leu Asp Gln Leu Thr Asp Pro 
        275                 280                 285             


Pro Gly Val Arg Arg Val His Ile Gln Ala Gly Leu Pro Asp Pro Phe 
    290                 295                 300                 


Gln Pro Pro Ser Leu Pro Ile Thr Val Tyr Tyr Ala Val Leu Glu Arg 
305                 310                 315                 320 


Ala Cys Arg Ser Val Leu Leu Asn Ala Pro Ser Glu Ala Pro Gln Ile 
                325                 330                 335     


Val Arg Gly Ala Ser Glu Asp Val Arg Lys Gln Pro Tyr Asn Leu Thr 
            340                 345                 350         


Ile Ala Trp Phe Arg Met Gly Gly Asn Cys Ala Ile Pro Ile Thr Val 
        355                 360                 365             


Met Glu Tyr Thr Glu Cys Ser Tyr Asn Lys Ser Leu Gly Ala Cys Pro 
    370                 375                 380                 


Ile Arg Thr Gln Pro Arg Trp Asn Tyr Tyr Asp Ser Phe Ser Ala Val 
385                 390                 395                 400 


Ser Glu Asp Asn Leu Gly Phe Leu Met His Ala Pro Ala Phe Glu Thr 
                405                 410                 415     


Ala Gly Thr Tyr Leu Arg Leu Val Lys Ile Asn Asp Trp Thr Glu Ile 
            420                 425                 430         


Thr Gln Phe Ile Leu Glu His Arg Ala Lys Gly Ser Cys Lys Tyr Ala 
        435                 440                 445             


Leu Pro Leu Arg Ile Pro Pro Ser Ala Cys Leu Ser Pro Gln Ala Tyr 
    450                 455                 460                 


Gln Gln Gly Val Thr Val Asp Ser Ile Gly Met Leu Pro Arg Phe Ile 
465                 470                 475                 480 


Pro Glu Asn Gln Arg Thr Val Ala Val Tyr Ser Leu Lys Ile Ala Gly 
                485                 490                 495     


Trp His Gly Pro Lys Ala Pro Tyr Thr Ser Thr Leu Leu Pro Pro Glu 
            500                 505                 510         


Leu Ser Glu Thr Pro Asn Ala Thr Gln Pro Glu Leu Ala Pro Glu Asp 
        515                 520                 525             


Pro Glu Asp Ser Ala Leu Leu Glu Asp Pro Val Gly Thr Val Ala Pro 
    530                 535                 540                 


Gln Ile Pro Pro Asn Trp His Ile Pro Ser Ile Gln Asp Ala Ala Thr 
545                 550                 555                 560 


Pro Tyr His Pro Pro Ala Thr Pro Asn Asn Met Gly Leu Ile Ala Gly 
                565                 570                 575     


Ala Val Gly Gly Ser Leu Leu Ala Ala Leu Val Ile Cys Gly Ile Val 
            580                 585                 590         


Tyr Trp Met His Arg Arg Thr Arg Lys Ala Pro Lys Arg Ile Arg Leu 
        595                 600                 605             


Pro His Ile Arg Glu Asp Asp Gln Pro Ser Ser His Gln Pro Leu Phe 
    610                 615                 620                 


Tyr 
625 


<210>  6
<211>  248
<212>  PRT
<213>  herpes simplex virus

<400>  6

Asp Ile Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Val His Asn 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Glu Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asp Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Ile Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ser Glu Met Ala Arg Pro 
    130                 135                 140                 


Gly Ala Ser Val Lys Leu Pro Cys Lys Ala Ser Gly Asp Thr Phe Thr 
145                 150                 155                 160 


Ser Tyr Trp Met His Trp Val Lys Gln Arg His Gly His Gly Pro Glu 
                165                 170                 175     


Trp Ile Gly Asn Ile Tyr Pro Gly Ser Gly Gly Thr Asn Tyr Ala Glu 
            180                 185                 190         


Lys Phe Lys Asn Lys Val Thr Leu Thr Val Asp Arg Ser Ser Arg Thr 
        195                 200                 205             


Val Tyr Met His Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Thr Arg Ser Gly Gly Pro Tyr Phe Phe Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Leu Thr Val Ser Ser 
                245             


<210>  7
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pVT Bac gD:scEGFR 5' primer

<400>  7
ccagcccggg caaagacatt ctaatgaccc aatctc                                 36


<210>  8
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pVT Bac gD:scEGFR 3' Primer

<400>  8
ggtatgcggc cgcttaatgg taaggcgtcg cggcgtcct                              39


<210>  9
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sal1EGFRvIIIF primer

<400>  9
gactagtcga caattcgttg gccgcatgcg a                                      31


<210>  10
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Xho1EGFRvIIIR primer

<400>  10
cactactcga gtcatgctcc aataaattca ctgctttg                               38


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UL5F primer

<400>  11
acgagcgtgg tgcggtcatg g                                                 21


<210>  12
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UL5R primer

<400>  12
gcgggttaat agacaatgac cacg                                              24


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UL5 qPCR F primer

<400>  13
atgccgtagt cggcgtttat                                                   20


<210>  14
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UL5 qPCR R primer

<400>  14
cgagtttgtc gagtccattg ac                                                22


<210>  15
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UL5 FAM MGB primer

<400>  15
atggccagct ccgtag                                                       16


