﻿               SEQUENCE LISTING

<110> Technische Universitaet Muenchen

<120> Amyloid inhibitory peptides

<130> U30854WO

<150> EP18176609.8
<151> 2018-06-07

<160> 21
 
<170> BiSSAP 1.3.6

<210> 1
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1,17
<223> covalent bond between position 1 and 17

<220> 
<223> SEQ ID NO:1

<220> 
<221> VARIANT
<222> 1,17
<223> selected from the following pairs: Cys/Cys, Asp/Lys,
      Asp/ornithine, Asp/2,4-diaminobutyric acid,
      Asp/2,3-diaminopropionic acid, Glu/Lys, Glu/ornithine,
      Glu/2,4-diaminobutyric acid, Glu/2,3-diaminopropionic acid;

<220> 
<221> VARIANT
<222> 2,5,6,10,13,15,16
<223> independently selected from glycine, asparagine, valine,
      histidine, leucine, serine, alanine, and threonine;

<220> 
<221> VARIANT
<222> 7,8,9
<223> independently selected from arginine, homoarginine, citrulline,
      ornithine, lysine, and norleucine;

<400> 1
Xaa Xaa Phe Leu Xaa Xaa Xaa Xaa Xaa Xaa Phe Gly Xaa Ile Xaa Xaa 
1               5                   10                  15      
Xaa 
    

<210> 2
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1,17
<223> covalent bond between position 1 and 17

<220> 
<223> SEQ ID NO:2

<220> 
<221> VARIANT
<222> 1,17
<223> selected from the following pairs: Cys/Cys, Asp/Lys,
      Asp/ornithine, Asp/2,4-diaminobutyric acid,
      Asp/2,3-diaminopropionic acid, Glu/Lys, Glu/ornithine,
      Glu/2,4-diaminobutyric acid, Glu/2,3-diaminopropionic acid;

<220> 
<221> VARIANT
<222> 2,5,6,10,13,15,16
<223> independently selected from glycine, asparagine, valine,
      histidine, leucine, serine, alanine, and threonine;

<220> 
<221> VARIANT
<222> 7,8,9
<223> independently selected from arginine, homoarginine, citrulline,
      ornithine, lysine, and norleucine;

<220> 
<221> MOD_RES
<222> 12,14
<223> N-Methylation

<400> 2
Xaa Xaa Phe Leu Xaa Xaa Xaa Xaa Xaa Xaa Phe Gly Xaa Ile Xaa Xaa 
1               5                   10                  15      
Xaa 
    

<210> 3
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<221> DISULFID
<222> 1,17
<223> disulfide bond from position 1 to position 17

<220> 
<223> SEQ ID NO:3

<220> 
<221> VARIANT
<222> 2,5,6,10,13,15,16
<223> independently selected from glycine, asparagine, valine,
      histidine, leucine, serine, alanine, and threonine;

<220> 
<221> MOD_RES
<222> 12,14
<223> N-Methylation

<400> 3
Cys Xaa Phe Leu Xaa Xaa Arg Arg Arg Xaa Phe Gly Xaa Ile Xaa Xaa 
1               5                   10                  15      
Cys 
    

<210> 4
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<221> DISULFID
<222> 1,17
<223> disulfide bond from position 1 to position 17

<220> 
<223> SEQ ID NO:4

<220> 
<221> VARIANT
<222> 2,5,6,10,13,15,16
<223> independently selected from glycine, asparagine, valine,
      histidine, leucine, serine, alanine, and threonine;

<400> 4
Cys Xaa Phe Leu Xaa Xaa Arg Arg Arg Xaa Phe Gly Xaa Ile Xaa Xaa 
1               5                   10                  15      
Cys 
    

<210> 5
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1,17
<223> disulfide bond from position 1 to position 17

<220> 
<223> SEQ ID NO:5

<220> 
<221> MOD_RES
<222> 12,14
<223> N-Methylation

<400> 5
Cys Asn Phe Leu Val His Arg Arg Arg Asn Phe Gly Ala Ile Leu Ser 
1               5                   10                  15      
Cys 
    

<210> 6
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1,17
<223> disulfide bond from position 1 to position 17

<220> 
<223> SEQ ID NO:6

<220> 
<221> MOD_RES
<222> 12,14
<223> N-Methylation

<400> 6
Cys Gly Phe Leu Gly Gly Arg Arg Arg Gly Phe Gly Gly Ile Gly Gly 
1               5                   10                  15      
Cys 
    

<210> 7
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1,17
<223> disulfide bond from position 1 to position 17

<220> 
<223> SEQ ID NO:7

<220> 
<221> SITE
<222> 7,8,9
<223> D-amino acid residue

<220> 
<221> MOD_RES
<222> 12,14
<223> N-Methylation

<400> 7
Cys Gly Phe Leu Gly Gly Arg Arg Arg Gly Phe Gly Gly Ile Gly Gly 
1               5                   10                  15      
Cys 
    

<210> 8
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1,17
<223> disulfide bond from position 1 to position 17

<220> 
<223> SEQ ID NO:8

<220> 
<221> SITE
<222> 3,4,7,8,9,11
<223> D-amino acid residue

<220> 
<221> MOD_RES
<222> 12,14
<223> N-Methylation

<400> 8
Cys Gly Phe Leu Gly Gly Arg Arg Arg Gly Phe Gly Gly Ile Gly Gly 
1               5                   10                  15      
Cys 
    

<210> 9
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1,3,4,7,8,9,11,17
<223> D-amino acid residue

<220> 
<221> SITE
<222> 1,17
<223> disulfide bond from position 1 to position 17

<220> 
<223> SEQ ID NO:9

<220> 
<221> MOD_RES
<222> 12,14
<223> N-Methylation

<400> 9
Cys Gly Phe Leu Gly Gly Arg Arg Arg Gly Phe Gly Gly Ile Gly Gly 
1               5                   10                  15      
Cys 
    

<210> 10
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1,17
<223> disulfide bond from position 1 to position 17

<220> 
<223> SEQ ID NO:10

<400> 10
Cys Asn Phe Leu Val His Arg Arg Arg Asn Phe Gly Ala Ile Leu Ser 
1               5                   10                  15      
Cys 
    

<210> 11
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1,17
<223> disulfide bond from position 1 to position 17

<220> 
<223> SEQ ID NO:11

<400> 11
Cys Gly Phe Leu Gly Gly Arg Arg Arg Gly Phe Gly Gly Ile Gly Gly 
1               5                   10                  15      
Cys 
    

<210> 12
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1,17
<223> disulfide bond from position 1 to position 17

<220> 
<223> SEQ ID NO:12

<220> 
<221> SITE
<222> 7,8,9
<223> D-amino acid residue

<400> 12
Cys Gly Phe Leu Gly Gly Arg Arg Arg Gly Phe Gly Gly Ile Gly Gly 
1               5                   10                  15      
Cys 
    

<210> 13
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1,17
<223> disulfide bond from position 1 to position 17

<220> 
<223> SEQ ID NO:13

<220> 
<221> SITE
<222> 3,4,7,8,9,11
<223> D-amino acid residue

<400> 13
Cys Gly Phe Leu Gly Gly Arg Arg Arg Gly Phe Gly Gly Ile Gly Gly 
1               5                   10                  15      
Cys 
    

<210> 14
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1,3,4,7,8,9,11,17
<223> D-amino acid residue

<220> 
<221> SITE
<222> 1,17
<223> disulfide bond from position 1 to position 17

<220> 
<223> SEQ ID NO:14

<400> 14
Cys Gly Phe Leu Gly Gly Arg Arg Arg Gly Phe Gly Gly Ile Gly Gly 
1               5                   10                  15      
Cys 
    

<210> 15
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> SEQ ID NO:15

<220> 
<221> MOD_RES
<222> 11,13
<223> N-Methylation

<400> 15
Asn Phe Leu Val His Arg Arg Arg Asn Phe Gly Ala Ile Leu Ser 
1               5                   10                  15  

<210> 16
<211> 42
<212> PRT
<213> Homo sapiens


<220> 
<223> Aβ 40(42)

<400> 16
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      
Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          
Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          

<210> 17
<211> 37
<212> PRT
<213> Homo sapiens


<220> 
<223> IAPP

<220> 
<221> SITE
<222> 2,7
<223> disulfide bond between position 2 and 7

<400> 17
Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      
Val His Ser Ser Asn Asn Phe Gly Ala Ile Leu Ser Ser Thr Asn Val 
            20                  25                  30          
Gly Ser Asn Thr Tyr 
        35          

<210> 18
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> R3-GI

<220> 
<221> MOD_RES
<222> 17,19
<223> N-Methylation

<400> 18
Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Arg Arg Arg Asn Phe 
1               5                   10                  15      
Gly Ala Ile Leu Ser 
            20      

<210> 19
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1,23
<223> disulfide bond between position 1 and 23

<220> 
<223> SEQ ID NO:19

<220> 
<221> MOD_RES
<222> 18,20
<223> N-Methylation

<400> 19
Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu Val His Arg Arg Arg Asn 
1               5                   10                  15      
Phe Gly Ala Ile Leu Ser Cys 
            20              

<210> 20
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> SEQ ID No: 20

<220> 
<221> MOD_RES
<222> 2,4
<223> N-Methylation

<220> 
<221> VARIANT
<222> 3
<223> Unspecified amino acid

<400> 20
Phe Gly Xaa Ile 
1               

<210> 21
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> SEQ ID No: 21

<220> 
<221> MOD_RES
<222> 12
<223> AMIDATION

<400> 21
Thr His Arg Pro Pro Met Trp Ser Pro Val Trp Pro 
1               5                   10          

