                         SEQUENCE LISTING

<110>  Universitaet des Saarlandes
 
<120>  Novel biomarkers for carcinoma diagnosis

<130>  SAR16291PCT

<150>  LU100824
<151>  2018-06-07

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  1200
<212>  DNA
<213>  Homo sapiens

<400>  1
atggcggaac gcaggagaca caagaagcgg atccaggaag ttggtgaacc atctaaagaa       60

gagaaggctg tggccaagta tcttcgattc aactgtccaa caaagtccac caatatgatg      120

ggtcaccggg ttgattattt tattgcttca aaagcagtgg actgtctttt ggattcaaag      180

tgggcaaagg ccaagaaagg agaggaagct ttatttacaa ccagggagtc tgtggttgac      240

tactgcaaca ggcttttaaa gaagcagttt tttcaccgag ccctaaaagt aatgaaaatg      300

aaatatgata aagacataaa gaaagaaaaa gataaaggaa aagctgaaag tggaaaagaa      360

gaagataaaa agagcaagaa agaaaatata aaggatgaga agacaaaaaa agaaaaagag      420

aaaaaaaaag atggtgaaaa ggaagaatcc aaaaaggagg aaactccagg aactcctaaa      480

aagaaggaaa ctaagaaaaa attcaaactt gagccacatg atgatcaggt ttttctggat      540

ggaaatgagg tgtatgtatg gatctatgac ccagttcact ttaaaacatt tgtcatggga      600

ttaattcttg tgattgcagt aatagcggcc accctcttcc ccctttggcc agcagaaatg      660

agagtaggtg tttattacct cagtgtgggt gcaggctgtt ttgtagccag tattcttctc      720

cttgctgttg ctcgatgcat tctatttctc atcatttggc tcataactgg aggaaggcac      780

cacttttggt tcttgccaaa tctgactgct gatgtgggct tcattgactc cttcaggcct      840

ctgtacacac atgaatacaa aggaccaaaa gcagacttaa agaaagatga gaagtctgaa      900

accaaaaagc aacagaagtc cgacagtgag gaaaagtcag acagtgagaa aaaggaagat      960

gaggagggga aagtaggacc aggaaatcat ggaacagaag gctcgggggg agaacggcat     1020

tcagacacgg acagtgacag gagggaagat gatcgatccc agcacagtag tggaaatgga     1080

aatgattttg aaatgataac aaaagaggaa ctggaacagc aaacagatgg ggattgtgaa     1140

gaggatgagg aagaggaaaa tgatggagaa acacctaaat cttcacatga aaaatcataa     1200


<210>  2
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Glu Arg Arg Arg His Lys Lys Arg Ile Gln Glu Val Gly Glu 
1               5                   10                  15      


Pro Ser Lys Glu Glu Lys Ala Val Ala Lys Tyr Leu Arg Phe Asn Cys 
            20                  25                  30          


Pro Thr Lys Ser Thr Asn Met Met Gly His Arg Val Asp Tyr Phe Ile 
        35                  40                  45              


Ala Ser Lys Ala Val Asp Cys Leu Leu Asp Ser Lys Trp Ala Lys Ala 
    50                  55                  60                  


Lys Lys Gly Glu Glu Ala Leu Phe Thr Thr Arg Glu Ser Val Val Asp 
65                  70                  75                  80  


Tyr Cys Asn Arg Leu Leu Lys Lys Gln Phe Phe His Arg Ala Leu Lys 
                85                  90                  95      


Val Met Lys Met Lys Tyr Asp Lys Asp Ile Lys Lys Glu Lys Asp Lys 
            100                 105                 110         


Gly Lys Ala Glu Ser Gly Lys Glu Glu Asp Lys Lys Ser Lys Lys Glu 
        115                 120                 125             


Asn Ile Lys Asp Glu Lys Thr Lys Lys Glu Lys Glu Lys Lys Lys Asp 
    130                 135                 140                 


Gly Glu Lys Glu Glu Ser Lys Lys Glu Glu Thr Pro Gly Thr Pro Lys 
145                 150                 155                 160 


Lys Lys Glu Thr Lys Lys Lys Phe Lys Leu Glu Pro His Asp Asp Gln 
                165                 170                 175     


Val Phe Leu Asp Gly Asn Glu Val Tyr Val Trp Ile Tyr Asp Pro Val 
            180                 185                 190         


His Phe Lys Thr Phe Val Met Gly Leu Ile Leu Val Ile Ala Val Ile 
        195                 200                 205             


Ala Ala Thr Leu Phe Pro Leu Trp Pro Ala Glu Met Arg Val Gly Val 
    210                 215                 220                 


Tyr Tyr Leu Ser Val Gly Ala Gly Cys Phe Val Ala Ser Ile Leu Leu 
225                 230                 235                 240 


Leu Ala Val Ala Arg Cys Ile Leu Phe Leu Ile Ile Trp Leu Ile Thr 
                245                 250                 255     


Gly Gly Arg His His Phe Trp Phe Leu Pro Asn Leu Thr Ala Asp Val 
            260                 265                 270         


Gly Phe Ile Asp Ser Phe Arg Pro Leu Tyr Thr His Glu Tyr Lys Gly 
        275                 280                 285             


Pro Lys Ala Asp Leu Lys Lys Asp Glu Lys Ser Glu Thr Lys Lys Gln 
    290                 295                 300                 


Gln Lys Ser Asp Ser Glu Glu Lys Ser Asp Ser Glu Lys Lys Glu Asp 
305                 310                 315                 320 


Glu Glu Gly Lys Val Gly Pro Gly Asn His Gly Thr Glu Gly Ser Gly 
                325                 330                 335     


Gly Glu Arg His Ser Asp Thr Asp Ser Asp Arg Arg Glu Asp Asp Arg 
            340                 345                 350         


Ser Gln His Ser Ser Gly Asn Gly Asn Asp Phe Glu Met Ile Thr Lys 
        355                 360                 365             


Glu Glu Leu Glu Gln Gln Thr Asp Gly Asp Cys Glu Glu Asp Glu Glu 
    370                 375                 380                 


Glu Glu Asn Asp Gly Glu Thr Pro Lys Ser Ser His Glu Lys Ser 
385                 390                 395                 


<210>  3
<211>  9771
<212>  DNA
<213>  Homo sapiens

<400>  3
atgtggccca cgagacgcct ggttactatc aaaaggagcg gggtcgacgg tccccacttt       60

cccctgagcc tcagcacctg cttgtttgga aggggtattg aatgtgacat ccgtatccag      120

cttcctgttg tgtcaaaaca acattgcaaa attgaaatcc atgagcagga ggcaatatta      180

cataatttca gttccacaaa tccaacacaa gtaaatgggt ctgttattga tgagcctgta      240

cggctaaaac atggagatgt aataactatt attgatcgtt ccttcaggta tgaaaatgaa      300

agtcttcaga atggaaggaa gtcaactgaa tttccaagaa aaatacgtga acaggagcca      360

gcacgtcgtg tctcaagatc tagcttctct tctgaccctg atgagaaagc tcaagattcc      420

aaggcctatt caaaaatcac tgaaggaaaa gtttcaggaa atcctcaggt acatatcaag      480

aatgtcaaag aagacagtac cgcagatgac tcaaaagaca gtgttgctca gggaacaact      540

aatgttcatt cctcagaaca tgctggacgt aatggcagaa atgcagctga tcccatttct      600

ggggatttta aagaaatttc cagcgttaaa ttagtgagcc gttatggaga attgaagtct      660

gttcccacta cacaatgtct tgacaatagc aaaaaaaatg aatctccctt ttggaagctt      720

tatgagtcag tgaagaaaga gttggatgta aaatcacaaa aagaaaatgt cctacagtat      780

tgtagaaaat ctggattaca aactgattac gcaacagaga aagaaagtgc tgatggttta      840

cagggggaga cccaactgtt ggtctcgcgt aagtcaagac caaaatctgg tgggagcggc      900

cacgctgtgg cagagcctgc ttcacctgaa caagagcttg accagaacaa ggggaaggga      960

agagacgtgg agtctgttca gactcccagc aaggctgtgg gcgccagctt tcctctctat     1020

gagccggcta aaatgaagac ccctgtacaa tattcacagc aacaaaattc tccacaaaaa     1080

cataagaaca aagacctgta tactactggt agaagagaat ctgtgaatct gggtaaaagt     1140

gaaggcttca aggctggtga taaaactctt actcccagga agctttcaac tagaaatcga     1200

acaccagcta aagttgaaga tgcagctgac tctgccacta agccagaaaa tctctcttcc     1260

aaaaccagag gaagtattcc tacagatgtg gaagttctgc ctacggaaac tgaaattcac     1320

aatgagccat ttttaactct gtggctcact caagttgaga ggaagatcca aaaggattcc     1380

ctcagcaagc ctgagaaatt gggcactaca gctggacaga tgtgctctgg gttacctggt     1440

cttagttcag ttgatatcaa caactttggt gattccatta atgagagtga gggaatacct     1500

ttgaaaagaa ggcgtgtgtc ctttggtggg cacctaagac ctgaactatt tgatgaaaac     1560

ttgcctccta atacgcctct caaaagggga gaagccccaa ccaaaagaaa gtctctggta     1620

atgcacactc cacctgtcct gaagaaaatc atcaaggaac agcctcaacc atcaggaaaa     1680

caagagtcag gttcagaaat ccatgtggaa gtgaaggcac aaagcttggt tataagccct     1740

ccagctccta gtcctaggaa aactccagtt gccagtgatc aacgccgtag gtcctgcaaa     1800

acagcccctg cttccagcag caaatctcag acagaggttc ctaagagagg agggagaaag     1860

agtggcaacc tgccttcaaa gagagtgtct atcagccgaa gtcaacatga tattttacag     1920

atgatatgtt ccaaaagaag aagtggtgct tcggaagcaa atctgattgt tgcaaaatca     1980

tgggcagatg tagtaaaact tggtgcaaaa caaacacaaa ctaaagtcat aaaacatggt     2040

cctcaaaggt caatgaacaa aaggcaaaga agacctgcta ctccaaagaa gcctgtgggc     2100

gaagttcaca gtcaatttag tacaggccac gcaaactctc cttgtaccat aataataggg     2160

aaagctcata ctgaaaaagt acatgtgcct gctcgaccct acagagtgct caacaacttc     2220

atttccaacc aaaaaatgga ctttaaggaa gatctttcag gaatagctga aatgttcaag     2280

accccagtga aggagcaacc gcagttgaca agcacatgtc acatcgctat ttcaaattca     2340

gagaatttgc ttggaaaaca gtttcaagga actgattcag gagaagaacc tctgctcccc     2400

acctcagaga gttttggagg aaatgtgttc ttcagtgcac agaatgcagc aaaacagcca     2460

tctgataaat gctctgcaag ccctccctta agacggcagt gtattagaga aaatggaaac     2520

gtagcaaaaa cgcccaggaa cacctacaaa atgacttctc tggagacaaa aacttcagat     2580

actgagacag agccttcaaa aacagtatcc actgcaaaca ggtcaggaag gtctacagag     2640

ttcaggaata tacagaagct acctgtggaa agtaagagtg aagaaacaaa tacagaaatt     2700

gttgagtgca tcctaaaaag aggtcagaag gcaacactac tacaacaaag gagagaagga     2760

gagatgaagg aaatagaaag accttttgag acatataagg aaaatattga attaaaagaa     2820

aacgatgaaa agatgaaagc aatgaagaga tcaagaactt gggggcagaa atgtgcacca     2880

atgtctgacc tgacagacct caagagcttg cctgatacag aactcatgaa agacacggca     2940

cgtggccaga atctcctcca aacccaagat catgccaagg caccaaagag tgagaaaggc     3000

aaaatcacta aaatgccctg ccagtcatta caaccagaac caataaacac cccaacacac     3060

acaaaacaac agttgaaggc atccctgggg aaagtaggtg tgaaagaaga gctcctagca     3120

gtcggcaagt tcacacggac gtcaggggag accacgcaca cgcacagaga gccagcagga     3180

gatggcaaga gcatcagaac gtttaaggag tctccaaagc agatcctgga cccagcagcc     3240

cgtgtaactg gaatgaagaa gtggccaaga acgcctaagg aagaggccca gtcactagaa     3300

gacctggctg gcttcaaaga gctcttccag acaccaggtc cctctgagga atcaatgact     3360

gatgagaaaa ctaccaaaat agcctgcaaa tctccaccac cagaatcagt ggacactcca     3420

acaagcacaa agcaatggcc taagagaagt ctcaggaaag cagatgtaga ggaagaattc     3480

ttagcactca ggaaactaac accatcagca gggaaagcca tgcttacgcc caaaccagca     3540

ggaggtgatg agaaagacat taaagcattt atgggaactc cagtgcagaa actggacctg     3600

gcaggaactt tacctggcag caaaagacag ctacagactc ctaaggaaaa ggcccaggct     3660

ctagaagacc tggctggctt taaagagctc ttccagactc ctggtcacac cgaggaatta     3720

gtggctgctg gtaaaaccac taaaataccc tgcgactctc cacagtcaga cccagtggac     3780

accccaacaa gcacaaagca acgacccaag agaagtatca ggaaagcaga tgtagaggga     3840

gaactcttag cgtgcaggaa tctaatgcca tcagcaggca aagccatgca cacgcctaaa     3900

ccatcagtag gtgaagagaa agacatcatc atatttgtgg gaactccagt gcagaaactg     3960

gacctgacag agaacttaac cggcagcaag agacggccac aaactcctaa ggaagaggcc     4020

caggctctgg aagacctgac tggctttaaa gagctcttcc agacccctgg tcatactgaa     4080

gaagcagtgg ctgctggcaa aactactaaa atgccctgcg aatcttctcc accagaatca     4140

gcagacaccc caacaagcac aagaaggcag cccaagacac ctttggagaa aagggacgta     4200

cagaaggagc tctcagccct gaagaagctc acacagacat caggggaaac cacacacaca     4260

gataaagtac caggaggtga ggataaaagc atcaacgcgt ttagggaaac tgcaaaacag     4320

aaactggacc cagcagcaag tgtaactggt agcaagaggc acccaaaaac taaggaaaag     4380

gcccaacccc tagaagacct ggctggcttg aaagagctct tccagacacc agtatgcact     4440

gacaagccca cgactcacga gaaaactacc aaaatagcct gcagatcaca accagaccca     4500

gtggacacac caacaagctc caagccacag tccaagagaa gtctcaggaa agtggacgta     4560

gaagaagaat tcttcgcact caggaaacga acaccatcag caggcaaagc catgcacaca     4620

cccaaaccag cagtaagtgg tgagaaaaac atctacgcat ttatgggaac tccagtgcag     4680

aaactggacc tgacagagaa cttaactggc agcaagagac ggctacaaac tcctaaggaa     4740

aaggcccagg ctctagaaga cctggctggc tttaaagagc tcttccagac acgaggtcac     4800

actgaggaat caatgactaa cgataaaact gccaaagtag cctgcaaatc ttcacaacca     4860

gacccagaca aaaacccagc aagctccaag cgacggctca agacatccct ggggaaagtg     4920

ggcgtgaaag aagagctcct agcagttggc aagctcacac agacatcagg agagactaca     4980

cacacacaca cagagccaac aggagatggt aagagcatga aagcatttat ggagtctcca     5040

aagcagatct tagactcagc agcaagtcta actggcagca agaggcagct gagaactcct     5100

aagggaaagt ctgaagtccc tgaagacctg gccggcttca tcgagctctt ccagacacca     5160

agtcacacta aggaatcaat gactaacgaa aaaactacca aagtatccta cagagcttca     5220

cagccagacc tagtggacac cccaacaagc tccaagccac agcccaagag aagtctcagg     5280

aaagcagaca ctgaagaaga atttttagca tttaggaaac aaacgccatc agcaggcaaa     5340

gccatgcaca cacccaaacc agcagtaggt gaagagaaag acatcaacac gtttttggga     5400

actccagtgc agaaactgga ccagccagga aatttacctg gcagcaatag acggctacaa     5460

actcgtaagg aaaaggccca ggctctagaa gaactgactg gcttcagaga gcttttccag     5520

acaccatgca ctgataaccc cacgactgat gagaaaacta ccaaaaaaat actctgcaaa     5580

tctccgcaat cagacccagc ggacacccca acaaacacaa agcaacggcc caagagaagc     5640

ctcaagaaag cagacgtaga ggaagaattt ttagcattca ggaaactaac accatcagca     5700

ggcaaagcca tgcacacgcc taaagcagca gtaggtgaag agaaagacat caacacattt     5760

gtggggactc cagtggagaa actggacctg ctaggaaatt tacctggcag caagagacgg     5820

ccacaaactc ctaaagaaaa ggccaaggct ctagaagatc tggctggctt caaagagctc     5880

ttccagacac caggtcacac tgaggaatca atgaccgatg acaaaatcac agaagtatcc     5940

tgcaaatctc cacaaccaga cccagtcaaa accccaacaa gctccaagca acgactcaag     6000

atatccttgg ggaaagtagg tgtgaaagaa gaggtcctac cagtcggcaa gctcacacag     6060

acgtcaggga agaccacaca gacacacaga gagacagcag gagatggaaa gagcatcaaa     6120

gcgtttaagg aatctgcaaa gcagatgctg gacccagcaa actatggaac tgggatggag     6180

aggtggccaa gaacacctaa ggaagaggcc caatcactag aagacctggc cggcttcaaa     6240

gagctcttcc agacaccaga ccacactgag gaatcaacaa ctgatgacaa aactaccaaa     6300

atagcctgca aatctccacc accagaatca atggacactc caacaagcac aaggaggcgg     6360

cccaaaacac ctttggggaa aagggatata gtggaagagc tctcagccct gaagcagctc     6420

acacagacca cacacacaga caaagtacca ggagatgagg ataaaggcat caacgtgttc     6480

agggaaactg caaaacagaa actggaccca gcagcaagtg taactggtag caagaggcag     6540

ccaagaactc ctaagggaaa agcccaaccc ctagaagact tggctggctt gaaagagctc     6600

ttccagacac caatatgcac tgacaagccc acgactcatg agaaaactac caaaatagcc     6660

tgcagatctc cacaaccaga cccagtgggt accccaacaa tcttcaagcc acagtccaag     6720

agaagtctca ggaaagcaga cgtagaggaa gaatccttag cactcaggaa acgaacacca     6780

tcagtaggga aagctatgga cacacccaaa ccagcaggag gtgatgagaa agacatgaaa     6840

gcatttatgg gaactccagt gcagaaattg gacctgccag gaaatttacc tggcagcaaa     6900

agatggccac aaactcctaa ggaaaaggcc caggctctag aagacctggc tggcttcaaa     6960

gagctcttcc agacaccagg cactgacaag cccacgactg atgagaaaac taccaaaata     7020

gcctgcaaat ctccacaacc agacccagtg gacaccccag caagcacaaa gcaacggccc     7080

aagagaaacc tcaggaaagc agacgtagag gaagaatttt tagcactcag gaaacgaaca     7140

ccatcagcag gcaaagccat ggacacacca aaaccagcag taagtgatga gaaaaatatc     7200

aacacatttg tggaaactcc agtgcagaaa ctggacctgc taggaaattt acctggcagc     7260

aagagacagc cacagactcc taaggaaaag gctgaggctc tagaggacct ggttggcttc     7320

aaagaactct tccagacacc aggtcacact gaggaatcaa tgactgatga caaaatcaca     7380

gaagtatcct gtaaatctcc acagccagag tcattcaaaa cctcaagaag ctccaagcaa     7440

aggctcaaga tacccctggt gaaagtggac atgaaagaag agcccctagc agtcagcaag     7500

ctcacacgga catcagggga gactacgcaa acacacacag agccaacagg agatagtaag     7560

agcatcaaag cgtttaagga gtctccaaag cagatcctgg acccagcagc aagtgtaact     7620

ggtagcagga ggcagctgag aactcgtaag gaaaaggccc gtgctctaga agacctggtt     7680

gacttcaaag agctcttctc agcaccaggt cacactgaag agtcaatgac tattgacaaa     7740

aacacaaaaa ttccctgcaa atctccccca ccagaactaa cagacactgc cacgagcaca     7800

aagagatgcc ccaagacacg tcccaggaaa gaagtaaaag aggagctctc agcagttgag     7860

aggctcacgc aaacatcagg gcaaagcaca cacacacaca aagaaccagc aagcggtgat     7920

gagggcatca aagtattgaa gcaacgtgca aagaagaaac caaacccagt agaagaggaa     7980

cccagcagga gaaggccaag agcacctaag gaaaaggccc aacccctgga agacctggcc     8040

ggcttcacag agctctctga aacatcaggt cacactcagg aatcactgac tgctggcaaa     8100

gccactaaaa taccctgcga atctccccca ctagaagtgg tagacaccac agcaagcaca     8160

aagaggcatc tcaggacacg tgtgcagaag gtacaagtaa aagaagagcc ttcagcagtc     8220

aagttcacac aaacatcagg ggaaaccacg gatgcagaca aagaaccagc aggtgaagat     8280

aaaggcatca aagcattgaa ggaatctgca aaacagacac cggctccagc agcaagtgta     8340

actggcagca ggagacggcc aagagcaccc agggaaagtg cccaagccat agaagaccta     8400

gctggcttca aagacccagc agcaggtcac actgaagaat caatgactga tgacaaaacc     8460

actaaaatac cctgcaaatc atcaccagaa ctagaagaca ccgcaacaag ctcaaagaga     8520

cggcccagga cacgtgccca gaaagtagaa gtgaaggagg agctgttagc agttggcaag     8580

ctcacacaaa cctcagggga gaccacgcac accgacaaag agccggtagg tgagggcaaa     8640

ggcacgaaag catttaagca acctgcaaag cggaagctgg acgcagaaga tgtaattggc     8700

agcaggagac agccaagagc acctaaggaa aaggcccaac ccctggaaga tctggccagc     8760

ttccaagagc tctctcaaac accaggccac actgaggaac tggcaaatgg tgctgctgat     8820

agctttacaa gcgctccaaa gcaaacacct gacagtggaa aacctctaaa aatatccaga     8880

agagttcttc gggcccctaa agtagaaccc gtgggagacg tggtaagcac cagagaccct     8940

gtaaaatcac aaagcaaaag caacacttcc ctgcccccac tgcccttcaa gaggggaggt     9000

ggcaaagatg gaagcgtcac gggaaccaag aggctgcgct gcatgccagc accagaggaa     9060

attgtggagg agctgccagc cagcaagaag cagagggttg ctcccagggc aagaggcaaa     9120

tcatccgaac ccgtggtcat catgaagaga agtttgagga cttctgcaaa aagaattgaa     9180

cctgcggaag agctgaacag caacgacatg aaaaccaaca aagaggaaca caaattacaa     9240

gactcggtcc ctgaaaataa gggaatatcc ctgcgctcca gacgccaaaa taagactgag     9300

gcagaacagc aaataactga ggtctttgta ttagcagaaa gaatagaaat aaacagaaat     9360

gaaaagaagc ccatgaagac ctccccagag atggacattc agaatccaga tgatggagcc     9420

cggaaaccca tacctagaga caaagtcact gagaacaaaa ggtgcttgag gtctgctaga     9480

cagaatgaga gctcccagcc taaggtggca gaggagagcg gagggcagaa gagtgcgaag     9540

gttctcatgc agaatcagaa agggaaagga gaagcaggaa attcagactc catgtgcctg     9600

agatcaagaa agacaaaaag ccagcctgca gcaagcactt tggagagcaa atctgtgcag     9660

agagtaacgc ggagtgtcaa gaggtgtgca gaaaatccaa agaaggctga ggacaatgtg     9720

tgtgtcaaga aaataagaac cagaagtcat agggacagtg aagatatttg a              9771


<210>  4
<211>  3256
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Trp Pro Thr Arg Arg Leu Val Thr Ile Lys Arg Ser Gly Val Asp 
1               5                   10                  15      


Gly Pro His Phe Pro Leu Ser Leu Ser Thr Cys Leu Phe Gly Arg Gly 
            20                  25                  30          


Ile Glu Cys Asp Ile Arg Ile Gln Leu Pro Val Val Ser Lys Gln His 
        35                  40                  45              


Cys Lys Ile Glu Ile His Glu Gln Glu Ala Ile Leu His Asn Phe Ser 
    50                  55                  60                  


Ser Thr Asn Pro Thr Gln Val Asn Gly Ser Val Ile Asp Glu Pro Val 
65                  70                  75                  80  


Arg Leu Lys His Gly Asp Val Ile Thr Ile Ile Asp Arg Ser Phe Arg 
                85                  90                  95      


Tyr Glu Asn Glu Ser Leu Gln Asn Gly Arg Lys Ser Thr Glu Phe Pro 
            100                 105                 110         


Arg Lys Ile Arg Glu Gln Glu Pro Ala Arg Arg Val Ser Arg Ser Ser 
        115                 120                 125             


Phe Ser Ser Asp Pro Asp Glu Lys Ala Gln Asp Ser Lys Ala Tyr Ser 
    130                 135                 140                 


Lys Ile Thr Glu Gly Lys Val Ser Gly Asn Pro Gln Val His Ile Lys 
145                 150                 155                 160 


Asn Val Lys Glu Asp Ser Thr Ala Asp Asp Ser Lys Asp Ser Val Ala 
                165                 170                 175     


Gln Gly Thr Thr Asn Val His Ser Ser Glu His Ala Gly Arg Asn Gly 
            180                 185                 190         


Arg Asn Ala Ala Asp Pro Ile Ser Gly Asp Phe Lys Glu Ile Ser Ser 
        195                 200                 205             


Val Lys Leu Val Ser Arg Tyr Gly Glu Leu Lys Ser Val Pro Thr Thr 
    210                 215                 220                 


Gln Cys Leu Asp Asn Ser Lys Lys Asn Glu Ser Pro Phe Trp Lys Leu 
225                 230                 235                 240 


Tyr Glu Ser Val Lys Lys Glu Leu Asp Val Lys Ser Gln Lys Glu Asn 
                245                 250                 255     


Val Leu Gln Tyr Cys Arg Lys Ser Gly Leu Gln Thr Asp Tyr Ala Thr 
            260                 265                 270         


Glu Lys Glu Ser Ala Asp Gly Leu Gln Gly Glu Thr Gln Leu Leu Val 
        275                 280                 285             


Ser Arg Lys Ser Arg Pro Lys Ser Gly Gly Ser Gly His Ala Val Ala 
    290                 295                 300                 


Glu Pro Ala Ser Pro Glu Gln Glu Leu Asp Gln Asn Lys Gly Lys Gly 
305                 310                 315                 320 


Arg Asp Val Glu Ser Val Gln Thr Pro Ser Lys Ala Val Gly Ala Ser 
                325                 330                 335     


Phe Pro Leu Tyr Glu Pro Ala Lys Met Lys Thr Pro Val Gln Tyr Ser 
            340                 345                 350         


Gln Gln Gln Asn Ser Pro Gln Lys His Lys Asn Lys Asp Leu Tyr Thr 
        355                 360                 365             


Thr Gly Arg Arg Glu Ser Val Asn Leu Gly Lys Ser Glu Gly Phe Lys 
    370                 375                 380                 


Ala Gly Asp Lys Thr Leu Thr Pro Arg Lys Leu Ser Thr Arg Asn Arg 
385                 390                 395                 400 


Thr Pro Ala Lys Val Glu Asp Ala Ala Asp Ser Ala Thr Lys Pro Glu 
                405                 410                 415     


Asn Leu Ser Ser Lys Thr Arg Gly Ser Ile Pro Thr Asp Val Glu Val 
            420                 425                 430         


Leu Pro Thr Glu Thr Glu Ile His Asn Glu Pro Phe Leu Thr Leu Trp 
        435                 440                 445             


Leu Thr Gln Val Glu Arg Lys Ile Gln Lys Asp Ser Leu Ser Lys Pro 
    450                 455                 460                 


Glu Lys Leu Gly Thr Thr Ala Gly Gln Met Cys Ser Gly Leu Pro Gly 
465                 470                 475                 480 


Leu Ser Ser Val Asp Ile Asn Asn Phe Gly Asp Ser Ile Asn Glu Ser 
                485                 490                 495     


Glu Gly Ile Pro Leu Lys Arg Arg Arg Val Ser Phe Gly Gly His Leu 
            500                 505                 510         


Arg Pro Glu Leu Phe Asp Glu Asn Leu Pro Pro Asn Thr Pro Leu Lys 
        515                 520                 525             


Arg Gly Glu Ala Pro Thr Lys Arg Lys Ser Leu Val Met His Thr Pro 
    530                 535                 540                 


Pro Val Leu Lys Lys Ile Ile Lys Glu Gln Pro Gln Pro Ser Gly Lys 
545                 550                 555                 560 


Gln Glu Ser Gly Ser Glu Ile His Val Glu Val Lys Ala Gln Ser Leu 
                565                 570                 575     


Val Ile Ser Pro Pro Ala Pro Ser Pro Arg Lys Thr Pro Val Ala Ser 
            580                 585                 590         


Asp Gln Arg Arg Arg Ser Cys Lys Thr Ala Pro Ala Ser Ser Ser Lys 
        595                 600                 605             


Ser Gln Thr Glu Val Pro Lys Arg Gly Gly Arg Lys Ser Gly Asn Leu 
    610                 615                 620                 


Pro Ser Lys Arg Val Ser Ile Ser Arg Ser Gln His Asp Ile Leu Gln 
625                 630                 635                 640 


Met Ile Cys Ser Lys Arg Arg Ser Gly Ala Ser Glu Ala Asn Leu Ile 
                645                 650                 655     


Val Ala Lys Ser Trp Ala Asp Val Val Lys Leu Gly Ala Lys Gln Thr 
            660                 665                 670         


Gln Thr Lys Val Ile Lys His Gly Pro Gln Arg Ser Met Asn Lys Arg 
        675                 680                 685             


Gln Arg Arg Pro Ala Thr Pro Lys Lys Pro Val Gly Glu Val His Ser 
    690                 695                 700                 


Gln Phe Ser Thr Gly His Ala Asn Ser Pro Cys Thr Ile Ile Ile Gly 
705                 710                 715                 720 


Lys Ala His Thr Glu Lys Val His Val Pro Ala Arg Pro Tyr Arg Val 
                725                 730                 735     


Leu Asn Asn Phe Ile Ser Asn Gln Lys Met Asp Phe Lys Glu Asp Leu 
            740                 745                 750         


Ser Gly Ile Ala Glu Met Phe Lys Thr Pro Val Lys Glu Gln Pro Gln 
        755                 760                 765             


Leu Thr Ser Thr Cys His Ile Ala Ile Ser Asn Ser Glu Asn Leu Leu 
    770                 775                 780                 


Gly Lys Gln Phe Gln Gly Thr Asp Ser Gly Glu Glu Pro Leu Leu Pro 
785                 790                 795                 800 


Thr Ser Glu Ser Phe Gly Gly Asn Val Phe Phe Ser Ala Gln Asn Ala 
                805                 810                 815     


Ala Lys Gln Pro Ser Asp Lys Cys Ser Ala Ser Pro Pro Leu Arg Arg 
            820                 825                 830         


Gln Cys Ile Arg Glu Asn Gly Asn Val Ala Lys Thr Pro Arg Asn Thr 
        835                 840                 845             


Tyr Lys Met Thr Ser Leu Glu Thr Lys Thr Ser Asp Thr Glu Thr Glu 
    850                 855                 860                 


Pro Ser Lys Thr Val Ser Thr Ala Asn Arg Ser Gly Arg Ser Thr Glu 
865                 870                 875                 880 


Phe Arg Asn Ile Gln Lys Leu Pro Val Glu Ser Lys Ser Glu Glu Thr 
                885                 890                 895     


Asn Thr Glu Ile Val Glu Cys Ile Leu Lys Arg Gly Gln Lys Ala Thr 
            900                 905                 910         


Leu Leu Gln Gln Arg Arg Glu Gly Glu Met Lys Glu Ile Glu Arg Pro 
        915                 920                 925             


Phe Glu Thr Tyr Lys Glu Asn Ile Glu Leu Lys Glu Asn Asp Glu Lys 
    930                 935                 940                 


Met Lys Ala Met Lys Arg Ser Arg Thr Trp Gly Gln Lys Cys Ala Pro 
945                 950                 955                 960 


Met Ser Asp Leu Thr Asp Leu Lys Ser Leu Pro Asp Thr Glu Leu Met 
                965                 970                 975     


Lys Asp Thr Ala Arg Gly Gln Asn Leu Leu Gln Thr Gln Asp His Ala 
            980                 985                 990         


Lys Ala Pro Lys Ser Glu Lys Gly  Lys Ile Thr Lys Met  Pro Cys Gln 
        995                 1000                 1005             


Ser Leu  Gln Pro Glu Pro Ile  Asn Thr Pro Thr His  Thr Lys Gln 
    1010                 1015                 1020             


Gln Leu  Lys Ala Ser Leu Gly  Lys Val Gly Val Lys  Glu Glu Leu 
    1025                 1030                 1035             


Leu Ala  Val Gly Lys Phe Thr  Arg Thr Ser Gly Glu  Thr Thr His 
    1040                 1045                 1050             


Thr His  Arg Glu Pro Ala Gly  Asp Gly Lys Ser Ile  Arg Thr Phe 
    1055                 1060                 1065             


Lys Glu  Ser Pro Lys Gln Ile  Leu Asp Pro Ala Ala  Arg Val Thr 
    1070                 1075                 1080             


Gly Met  Lys Lys Trp Pro Arg  Thr Pro Lys Glu Glu  Ala Gln Ser 
    1085                 1090                 1095             


Leu Glu  Asp Leu Ala Gly Phe  Lys Glu Leu Phe Gln  Thr Pro Gly 
    1100                 1105                 1110             


Pro Ser  Glu Glu Ser Met Thr  Asp Glu Lys Thr Thr  Lys Ile Ala 
    1115                 1120                 1125             


Cys Lys  Ser Pro Pro Pro Glu  Ser Val Asp Thr Pro  Thr Ser Thr 
    1130                 1135                 1140             


Lys Gln  Trp Pro Lys Arg Ser  Leu Arg Lys Ala Asp  Val Glu Glu 
    1145                 1150                 1155             


Glu Phe  Leu Ala Leu Arg Lys  Leu Thr Pro Ser Ala  Gly Lys Ala 
    1160                 1165                 1170             


Met Leu  Thr Pro Lys Pro Ala  Gly Gly Asp Glu Lys  Asp Ile Lys 
    1175                 1180                 1185             


Ala Phe  Met Gly Thr Pro Val  Gln Lys Leu Asp Leu  Ala Gly Thr 
    1190                 1195                 1200             


Leu Pro  Gly Ser Lys Arg Gln  Leu Gln Thr Pro Lys  Glu Lys Ala 
    1205                 1210                 1215             


Gln Ala  Leu Glu Asp Leu Ala  Gly Phe Lys Glu Leu  Phe Gln Thr 
    1220                 1225                 1230             


Pro Gly  His Thr Glu Glu Leu  Val Ala Ala Gly Lys  Thr Thr Lys 
    1235                 1240                 1245             


Ile Pro  Cys Asp Ser Pro Gln  Ser Asp Pro Val Asp  Thr Pro Thr 
    1250                 1255                 1260             


Ser Thr  Lys Gln Arg Pro Lys  Arg Ser Ile Arg Lys  Ala Asp Val 
    1265                 1270                 1275             


Glu Gly  Glu Leu Leu Ala Cys  Arg Asn Leu Met Pro  Ser Ala Gly 
    1280                 1285                 1290             


Lys Ala  Met His Thr Pro Lys  Pro Ser Val Gly Glu  Glu Lys Asp 
    1295                 1300                 1305             


Ile Ile  Ile Phe Val Gly Thr  Pro Val Gln Lys Leu  Asp Leu Thr 
    1310                 1315                 1320             


Glu Asn  Leu Thr Gly Ser Lys  Arg Arg Pro Gln Thr  Pro Lys Glu 
    1325                 1330                 1335             


Glu Ala  Gln Ala Leu Glu Asp  Leu Thr Gly Phe Lys  Glu Leu Phe 
    1340                 1345                 1350             


Gln Thr  Pro Gly His Thr Glu  Glu Ala Val Ala Ala  Gly Lys Thr 
    1355                 1360                 1365             


Thr Lys  Met Pro Cys Glu Ser  Ser Pro Pro Glu Ser  Ala Asp Thr 
    1370                 1375                 1380             


Pro Thr  Ser Thr Arg Arg Gln  Pro Lys Thr Pro Leu  Glu Lys Arg 
    1385                 1390                 1395             


Asp Val  Gln Lys Glu Leu Ser  Ala Leu Lys Lys Leu  Thr Gln Thr 
    1400                 1405                 1410             


Ser Gly  Glu Thr Thr His Thr  Asp Lys Val Pro Gly  Gly Glu Asp 
    1415                 1420                 1425             


Lys Ser  Ile Asn Ala Phe Arg  Glu Thr Ala Lys Gln  Lys Leu Asp 
    1430                 1435                 1440             


Pro Ala  Ala Ser Val Thr Gly  Ser Lys Arg His Pro  Lys Thr Lys 
    1445                 1450                 1455             


Glu Lys  Ala Gln Pro Leu Glu  Asp Leu Ala Gly Leu  Lys Glu Leu 
    1460                 1465                 1470             


Phe Gln  Thr Pro Val Cys Thr  Asp Lys Pro Thr Thr  His Glu Lys 
    1475                 1480                 1485             


Thr Thr  Lys Ile Ala Cys Arg  Ser Gln Pro Asp Pro  Val Asp Thr 
    1490                 1495                 1500             


Pro Thr  Ser Ser Lys Pro Gln  Ser Lys Arg Ser Leu  Arg Lys Val 
    1505                 1510                 1515             


Asp Val  Glu Glu Glu Phe Phe  Ala Leu Arg Lys Arg  Thr Pro Ser 
    1520                 1525                 1530             


Ala Gly  Lys Ala Met His Thr  Pro Lys Pro Ala Val  Ser Gly Glu 
    1535                 1540                 1545             


Lys Asn  Ile Tyr Ala Phe Met  Gly Thr Pro Val Gln  Lys Leu Asp 
    1550                 1555                 1560             


Leu Thr  Glu Asn Leu Thr Gly  Ser Lys Arg Arg Leu  Gln Thr Pro 
    1565                 1570                 1575             


Lys Glu  Lys Ala Gln Ala Leu  Glu Asp Leu Ala Gly  Phe Lys Glu 
    1580                 1585                 1590             


Leu Phe  Gln Thr Arg Gly His  Thr Glu Glu Ser Met  Thr Asn Asp 
    1595                 1600                 1605             


Lys Thr  Ala Lys Val Ala Cys  Lys Ser Ser Gln Pro  Asp Pro Asp 
    1610                 1615                 1620             


Lys Asn  Pro Ala Ser Ser Lys  Arg Arg Leu Lys Thr  Ser Leu Gly 
    1625                 1630                 1635             


Lys Val  Gly Val Lys Glu Glu  Leu Leu Ala Val Gly  Lys Leu Thr 
    1640                 1645                 1650             


Gln Thr  Ser Gly Glu Thr Thr  His Thr His Thr Glu  Pro Thr Gly 
    1655                 1660                 1665             


Asp Gly  Lys Ser Met Lys Ala  Phe Met Glu Ser Pro  Lys Gln Ile 
    1670                 1675                 1680             


Leu Asp  Ser Ala Ala Ser Leu  Thr Gly Ser Lys Arg  Gln Leu Arg 
    1685                 1690                 1695             


Thr Pro  Lys Gly Lys Ser Glu  Val Pro Glu Asp Leu  Ala Gly Phe 
    1700                 1705                 1710             


Ile Glu  Leu Phe Gln Thr Pro  Ser His Thr Lys Glu  Ser Met Thr 
    1715                 1720                 1725             


Asn Glu  Lys Thr Thr Lys Val  Ser Tyr Arg Ala Ser  Gln Pro Asp 
    1730                 1735                 1740             


Leu Val  Asp Thr Pro Thr Ser  Ser Lys Pro Gln Pro  Lys Arg Ser 
    1745                 1750                 1755             


Leu Arg  Lys Ala Asp Thr Glu  Glu Glu Phe Leu Ala  Phe Arg Lys 
    1760                 1765                 1770             


Gln Thr  Pro Ser Ala Gly Lys  Ala Met His Thr Pro  Lys Pro Ala 
    1775                 1780                 1785             


Val Gly  Glu Glu Lys Asp Ile  Asn Thr Phe Leu Gly  Thr Pro Val 
    1790                 1795                 1800             


Gln Lys  Leu Asp Gln Pro Gly  Asn Leu Pro Gly Ser  Asn Arg Arg 
    1805                 1810                 1815             


Leu Gln  Thr Arg Lys Glu Lys  Ala Gln Ala Leu Glu  Glu Leu Thr 
    1820                 1825                 1830             


Gly Phe  Arg Glu Leu Phe Gln  Thr Pro Cys Thr Asp  Asn Pro Thr 
    1835                 1840                 1845             


Thr Asp  Glu Lys Thr Thr Lys  Lys Ile Leu Cys Lys  Ser Pro Gln 
    1850                 1855                 1860             


Ser Asp  Pro Ala Asp Thr Pro  Thr Asn Thr Lys Gln  Arg Pro Lys 
    1865                 1870                 1875             


Arg Ser  Leu Lys Lys Ala Asp  Val Glu Glu Glu Phe  Leu Ala Phe 
    1880                 1885                 1890             


Arg Lys  Leu Thr Pro Ser Ala  Gly Lys Ala Met His  Thr Pro Lys 
    1895                 1900                 1905             


Ala Ala  Val Gly Glu Glu Lys  Asp Ile Asn Thr Phe  Val Gly Thr 
    1910                 1915                 1920             


Pro Val  Glu Lys Leu Asp Leu  Leu Gly Asn Leu Pro  Gly Ser Lys 
    1925                 1930                 1935             


Arg Arg  Pro Gln Thr Pro Lys  Glu Lys Ala Lys Ala  Leu Glu Asp 
    1940                 1945                 1950             


Leu Ala  Gly Phe Lys Glu Leu  Phe Gln Thr Pro Gly  His Thr Glu 
    1955                 1960                 1965             


Glu Ser  Met Thr Asp Asp Lys  Ile Thr Glu Val Ser  Cys Lys Ser 
    1970                 1975                 1980             


Pro Gln  Pro Asp Pro Val Lys  Thr Pro Thr Ser Ser  Lys Gln Arg 
    1985                 1990                 1995             


Leu Lys  Ile Ser Leu Gly Lys  Val Gly Val Lys Glu  Glu Val Leu 
    2000                 2005                 2010             


Pro Val  Gly Lys Leu Thr Gln  Thr Ser Gly Lys Thr  Thr Gln Thr 
    2015                 2020                 2025             


His Arg  Glu Thr Ala Gly Asp  Gly Lys Ser Ile Lys  Ala Phe Lys 
    2030                 2035                 2040             


Glu Ser  Ala Lys Gln Met Leu  Asp Pro Ala Asn Tyr  Gly Thr Gly 
    2045                 2050                 2055             


Met Glu  Arg Trp Pro Arg Thr  Pro Lys Glu Glu Ala  Gln Ser Leu 
    2060                 2065                 2070             


Glu Asp  Leu Ala Gly Phe Lys  Glu Leu Phe Gln Thr  Pro Asp His 
    2075                 2080                 2085             


Thr Glu  Glu Ser Thr Thr Asp  Asp Lys Thr Thr Lys  Ile Ala Cys 
    2090                 2095                 2100             


Lys Ser  Pro Pro Pro Glu Ser  Met Asp Thr Pro Thr  Ser Thr Arg 
    2105                 2110                 2115             


Arg Arg  Pro Lys Thr Pro Leu  Gly Lys Arg Asp Ile  Val Glu Glu 
    2120                 2125                 2130             


Leu Ser  Ala Leu Lys Gln Leu  Thr Gln Thr Thr His  Thr Asp Lys 
    2135                 2140                 2145             


Val Pro  Gly Asp Glu Asp Lys  Gly Ile Asn Val Phe  Arg Glu Thr 
    2150                 2155                 2160             


Ala Lys  Gln Lys Leu Asp Pro  Ala Ala Ser Val Thr  Gly Ser Lys 
    2165                 2170                 2175             


Arg Gln  Pro Arg Thr Pro Lys  Gly Lys Ala Gln Pro  Leu Glu Asp 
    2180                 2185                 2190             


Leu Ala  Gly Leu Lys Glu Leu  Phe Gln Thr Pro Ile  Cys Thr Asp 
    2195                 2200                 2205             


Lys Pro  Thr Thr His Glu Lys  Thr Thr Lys Ile Ala  Cys Arg Ser 
    2210                 2215                 2220             


Pro Gln  Pro Asp Pro Val Gly  Thr Pro Thr Ile Phe  Lys Pro Gln 
    2225                 2230                 2235             


Ser Lys  Arg Ser Leu Arg Lys  Ala Asp Val Glu Glu  Glu Ser Leu 
    2240                 2245                 2250             


Ala Leu  Arg Lys Arg Thr Pro  Ser Val Gly Lys Ala  Met Asp Thr 
    2255                 2260                 2265             


Pro Lys  Pro Ala Gly Gly Asp  Glu Lys Asp Met Lys  Ala Phe Met 
    2270                 2275                 2280             


Gly Thr  Pro Val Gln Lys Leu  Asp Leu Pro Gly Asn  Leu Pro Gly 
    2285                 2290                 2295             


Ser Lys  Arg Trp Pro Gln Thr  Pro Lys Glu Lys Ala  Gln Ala Leu 
    2300                 2305                 2310             


Glu Asp  Leu Ala Gly Phe Lys  Glu Leu Phe Gln Thr  Pro Gly Thr 
    2315                 2320                 2325             


Asp Lys  Pro Thr Thr Asp Glu  Lys Thr Thr Lys Ile  Ala Cys Lys 
    2330                 2335                 2340             


Ser Pro  Gln Pro Asp Pro Val  Asp Thr Pro Ala Ser  Thr Lys Gln 
    2345                 2350                 2355             


Arg Pro  Lys Arg Asn Leu Arg  Lys Ala Asp Val Glu  Glu Glu Phe 
    2360                 2365                 2370             


Leu Ala  Leu Arg Lys Arg Thr  Pro Ser Ala Gly Lys  Ala Met Asp 
    2375                 2380                 2385             


Thr Pro  Lys Pro Ala Val Ser  Asp Glu Lys Asn Ile  Asn Thr Phe 
    2390                 2395                 2400             


Val Glu  Thr Pro Val Gln Lys  Leu Asp Leu Leu Gly  Asn Leu Pro 
    2405                 2410                 2415             


Gly Ser  Lys Arg Gln Pro Gln  Thr Pro Lys Glu Lys  Ala Glu Ala 
    2420                 2425                 2430             


Leu Glu  Asp Leu Val Gly Phe  Lys Glu Leu Phe Gln  Thr Pro Gly 
    2435                 2440                 2445             


His Thr  Glu Glu Ser Met Thr  Asp Asp Lys Ile Thr  Glu Val Ser 
    2450                 2455                 2460             


Cys Lys  Ser Pro Gln Pro Glu  Ser Phe Lys Thr Ser  Arg Ser Ser 
    2465                 2470                 2475             


Lys Gln  Arg Leu Lys Ile Pro  Leu Val Lys Val Asp  Met Lys Glu 
    2480                 2485                 2490             


Glu Pro  Leu Ala Val Ser Lys  Leu Thr Arg Thr Ser  Gly Glu Thr 
    2495                 2500                 2505             


Thr Gln  Thr His Thr Glu Pro  Thr Gly Asp Ser Lys  Ser Ile Lys 
    2510                 2515                 2520             


Ala Phe  Lys Glu Ser Pro Lys  Gln Ile Leu Asp Pro  Ala Ala Ser 
    2525                 2530                 2535             


Val Thr  Gly Ser Arg Arg Gln  Leu Arg Thr Arg Lys  Glu Lys Ala 
    2540                 2545                 2550             


Arg Ala  Leu Glu Asp Leu Val  Asp Phe Lys Glu Leu  Phe Ser Ala 
    2555                 2560                 2565             


Pro Gly  His Thr Glu Glu Ser  Met Thr Ile Asp Lys  Asn Thr Lys 
    2570                 2575                 2580             


Ile Pro  Cys Lys Ser Pro Pro  Pro Glu Leu Thr Asp  Thr Ala Thr 
    2585                 2590                 2595             


Ser Thr  Lys Arg Cys Pro Lys  Thr Arg Pro Arg Lys  Glu Val Lys 
    2600                 2605                 2610             


Glu Glu  Leu Ser Ala Val Glu  Arg Leu Thr Gln Thr  Ser Gly Gln 
    2615                 2620                 2625             


Ser Thr  His Thr His Lys Glu  Pro Ala Ser Gly Asp  Glu Gly Ile 
    2630                 2635                 2640             


Lys Val  Leu Lys Gln Arg Ala  Lys Lys Lys Pro Asn  Pro Val Glu 
    2645                 2650                 2655             


Glu Glu  Pro Ser Arg Arg Arg  Pro Arg Ala Pro Lys  Glu Lys Ala 
    2660                 2665                 2670             


Gln Pro  Leu Glu Asp Leu Ala  Gly Phe Thr Glu Leu  Ser Glu Thr 
    2675                 2680                 2685             


Ser Gly  His Thr Gln Glu Ser  Leu Thr Ala Gly Lys  Ala Thr Lys 
    2690                 2695                 2700             


Ile Pro  Cys Glu Ser Pro Pro  Leu Glu Val Val Asp  Thr Thr Ala 
    2705                 2710                 2715             


Ser Thr  Lys Arg His Leu Arg  Thr Arg Val Gln Lys  Val Gln Val 
    2720                 2725                 2730             


Lys Glu  Glu Pro Ser Ala Val  Lys Phe Thr Gln Thr  Ser Gly Glu 
    2735                 2740                 2745             


Thr Thr  Asp Ala Asp Lys Glu  Pro Ala Gly Glu Asp  Lys Gly Ile 
    2750                 2755                 2760             


Lys Ala  Leu Lys Glu Ser Ala  Lys Gln Thr Pro Ala  Pro Ala Ala 
    2765                 2770                 2775             


Ser Val  Thr Gly Ser Arg Arg  Arg Pro Arg Ala Pro  Arg Glu Ser 
    2780                 2785                 2790             


Ala Gln  Ala Ile Glu Asp Leu  Ala Gly Phe Lys Asp  Pro Ala Ala 
    2795                 2800                 2805             


Gly His  Thr Glu Glu Ser Met  Thr Asp Asp Lys Thr  Thr Lys Ile 
    2810                 2815                 2820             


Pro Cys  Lys Ser Ser Pro Glu  Leu Glu Asp Thr Ala  Thr Ser Ser 
    2825                 2830                 2835             


Lys Arg  Arg Pro Arg Thr Arg  Ala Gln Lys Val Glu  Val Lys Glu 
    2840                 2845                 2850             


Glu Leu  Leu Ala Val Gly Lys  Leu Thr Gln Thr Ser  Gly Glu Thr 
    2855                 2860                 2865             


Thr His  Thr Asp Lys Glu Pro  Val Gly Glu Gly Lys  Gly Thr Lys 
    2870                 2875                 2880             


Ala Phe  Lys Gln Pro Ala Lys  Arg Lys Leu Asp Ala  Glu Asp Val 
    2885                 2890                 2895             


Ile Gly  Ser Arg Arg Gln Pro  Arg Ala Pro Lys Glu  Lys Ala Gln 
    2900                 2905                 2910             


Pro Leu  Glu Asp Leu Ala Ser  Phe Gln Glu Leu Ser  Gln Thr Pro 
    2915                 2920                 2925             


Gly His  Thr Glu Glu Leu Ala  Asn Gly Ala Ala Asp  Ser Phe Thr 
    2930                 2935                 2940             


Ser Ala  Pro Lys Gln Thr Pro  Asp Ser Gly Lys Pro  Leu Lys Ile 
    2945                 2950                 2955             


Ser Arg  Arg Val Leu Arg Ala  Pro Lys Val Glu Pro  Val Gly Asp 
    2960                 2965                 2970             


Val Val  Ser Thr Arg Asp Pro  Val Lys Ser Gln Ser  Lys Ser Asn 
    2975                 2980                 2985             


Thr Ser  Leu Pro Pro Leu Pro  Phe Lys Arg Gly Gly  Gly Lys Asp 
    2990                 2995                 3000             


Gly Ser  Val Thr Gly Thr Lys  Arg Leu Arg Cys Met  Pro Ala Pro 
    3005                 3010                 3015             


Glu Glu  Ile Val Glu Glu Leu  Pro Ala Ser Lys Lys  Gln Arg Val 
    3020                 3025                 3030             


Ala Pro  Arg Ala Arg Gly Lys  Ser Ser Glu Pro Val  Val Ile Met 
    3035                 3040                 3045             


Lys Arg  Ser Leu Arg Thr Ser  Ala Lys Arg Ile Glu  Pro Ala Glu 
    3050                 3055                 3060             


Glu Leu  Asn Ser Asn Asp Met  Lys Thr Asn Lys Glu  Glu His Lys 
    3065                 3070                 3075             


Leu Gln  Asp Ser Val Pro Glu  Asn Lys Gly Ile Ser  Leu Arg Ser 
    3080                 3085                 3090             


Arg Arg  Gln Asn Lys Thr Glu  Ala Glu Gln Gln Ile  Thr Glu Val 
    3095                 3100                 3105             


Phe Val  Leu Ala Glu Arg Ile  Glu Ile Asn Arg Asn  Glu Lys Lys 
    3110                 3115                 3120             


Pro Met  Lys Thr Ser Pro Glu  Met Asp Ile Gln Asn  Pro Asp Asp 
    3125                 3130                 3135             


Gly Ala  Arg Lys Pro Ile Pro  Arg Asp Lys Val Thr  Glu Asn Lys 
    3140                 3145                 3150             


Arg Cys  Leu Arg Ser Ala Arg  Gln Asn Glu Ser Ser  Gln Pro Lys 
    3155                 3160                 3165             


Val Ala  Glu Glu Ser Gly Gly  Gln Lys Ser Ala Lys  Val Leu Met 
    3170                 3175                 3180             


Gln Asn  Gln Lys Gly Lys Gly  Glu Ala Gly Asn Ser  Asp Ser Met 
    3185                 3190                 3195             


Cys Leu  Arg Ser Arg Lys Thr  Lys Ser Gln Pro Ala  Ala Ser Thr 
    3200                 3205                 3210             


Leu Glu  Ser Lys Ser Val Gln  Arg Val Thr Arg Ser  Val Lys Arg 
    3215                 3220                 3225             


Cys Ala  Glu Asn Pro Lys Lys  Ala Glu Asp Asn Val  Cys Val Lys 
    3230                 3235                 3240             


Lys Ile  Arg Thr Arg Ser His  Arg Asp Ser Glu Asp  Ile 
    3245                 3250                 3255     


