                         SEQUENCE LISTING

<110>  LEADARTIS, S.L.
 
<120>  TRIMERIC POLYPEPTIDE COMPLEXES AND USES THEREOF

<130>  P16311PC00

<150>  EP18382401
<151>  2018-06-06

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  59
<212>  PRT
<213>  Artificial sequence

<220>
<223>  COLLAGEN XVIII TRIMERIZATION DOMAIN

<400>  1

Ser Gly Val Ala Leu Thr Ala Thr Ala Gly Ala Met Leu Gly Gly Val 
1               5                   10                  15      


His Gly Val Pro Gly Gly Thr Leu Ile Pro Val Ala Gly Gly Gly Gly 
            20                  25                  30          


Leu Thr Val Ala Val Gly Ala Gly Pro Ala Leu Val Gly Leu Gly Ala 
        35                  40                  45              


Ala Thr Pro Leu Pro Ala Gly Thr Ala Ala Gly 
    50                  55                  


<210>  2
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Collagen XV trimerization domain

<400>  2

Val Thr Ala Pro Ser Ala Met Ala Ala Met Leu Gly Leu Ala His Leu 
1               5                   10                  15      


Val Ile Gly Gly Thr Pro Ile Thr Leu Ala Ala Ser Thr Gly Pro Pro 
            20                  25                  30          


Ile Ala Val Ala Ala Gly Thr Leu Leu Leu Gly Leu Gly Gly Leu Ile 
        35                  40                  45              


Pro Ile Pro Ala Ala Ser Pro Pro Pro Pro Ala Leu Ser Ser Ala Pro 
    50                  55                  60                  


<210>  3
<211>  396
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Ega1 (VHH)

<400>  3

Ala Thr Gly Gly Cys Thr Cys Ala Gly Gly Thr Gly Cys Ala Gly Cys 
1               5                   10                  15      


Thr Gly Cys Ala Gly Gly Ala Gly Thr Cys Thr Gly Gly Gly Gly Gly 
            20                  25                  30          


Ala Gly Gly Ala Thr Thr Gly Gly Thr Gly Cys Ala Gly Cys Cys Ala 
        35                  40                  45              


Gly Gly Gly Gly Gly Cys Thr Cys Gly Cys Thr Gly Ala Gly Ala Cys 
    50                  55                  60                  


Thr Cys Thr Cys Cys Thr Gly Thr Gly Cys Ala Gly Cys Cys Thr Cys 
65                  70                  75                  80  


Thr Gly Gly Ala Cys Gly Cys Ala Cys Cys Thr Thr Cys Ala Gly Thr 
                85                  90                  95      


Ala Gly Cys Thr Ala Thr Gly Cys Cys Ala Thr Gly Gly Gly Cys Thr 
            100                 105                 110         


Gly Gly Thr Thr Cys Cys Gly Cys Cys Ala Gly Gly Cys Thr Cys Cys 
        115                 120                 125             


Ala Gly Gly Gly Ala Ala Gly Gly Ala Gly Cys Gly Thr Gly Ala Gly 
    130                 135                 140                 


Thr Thr Thr Gly Thr Ala Gly Cys Ala Gly Cys Thr Ala Thr Thr Ala 
145                 150                 155                 160 


Gly Gly Thr Gly Gly Ala Gly Thr Gly Gly Thr Gly Gly Thr Thr Ala 
                165                 170                 175     


Cys Ala Cys Ala Thr Ala Cys Thr Ala Thr Ala Cys Ala Gly Ala Cys 
            180                 185                 190         


Thr Cys Cys Gly Thr Gly Ala Ala Gly Gly Gly Cys Cys Gly Ala Thr 
        195                 200                 205             


Thr Cys Ala Cys Cys Ala Thr Cys Thr Cys Cys Ala Gly Ala Gly Ala 
    210                 215                 220                 


Cys Ala Ala Cys Gly Cys Cys Ala Ala Gly Ala Cys Thr Ala Cys Gly 
225                 230                 235                 240 


Gly Thr Gly Thr Ala Thr Cys Thr Gly Cys Ala Ala Ala Thr Gly Ala 
                245                 250                 255     


Ala Cys Ala Gly Cys Cys Thr Gly Ala Ala Ala Cys Cys Thr Gly Ala 
            260                 265                 270         


Gly Gly Ala Cys Ala Cys Gly Gly Cys Cys Gly Thr Thr Thr Ala Thr 
        275                 280                 285             


Thr Ala Cys Thr Gly Thr Gly Cys Ala Gly Cys Ala Ala Cys Ala Thr 
    290                 295                 300                 


Ala Cys Cys Thr Cys Thr Cys Cys Thr Cys Gly Gly Ala Cys Thr Ala 
305                 310                 315                 320 


Thr Ala Gly Cys Cys Gly Cys Thr Ala Thr Gly Cys Gly Thr Thr Gly 
                325                 330                 335     


Cys Cys Cys Cys Ala Ala Ala Gly Gly Cys Cys Cys Thr Thr Gly Gly 
            340                 345                 350         


Ala Cys Thr Ala Thr Gly Ala Cys Thr Ala Cys Thr Gly Gly Gly Gly 
        355                 360                 365             


Cys Cys Ala Gly Gly Gly Gly Ala Cys Cys Cys Ala Gly Gly Thr Cys 
    370                 375                 380                 


Ala Cys Cys Gly Thr Cys Thr Cys Cys Thr Cys Ala 
385                 390                 395     


<210>  4
<211>  130
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Ega1 (VHH)

<400>  4

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Gly Gly Tyr Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Thr Tyr Leu Ser Ser Asp Tyr Ser Arg Tyr Ala Leu Pro Gln 
            100                 105                 110         


Arg Pro Leu Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  5
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Ega1 (VHH) CDR1

<400>  5

Gly Arg Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  6
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Ega1 (VHH) CDR2

<400>  6

Ile Arg Trp Ser Gly Gly Tyr Thr 
1               5               


<210>  7
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Ega1 (VHH) CDR3

<400>  7

Ala Ala Thr Tyr Leu Ser Ser Asp Tyr Ser Arg Tyr Ala Leu Pro Gln 
1               5                   10                  15      


Arg Pro Leu Asp Tyr Asp Tyr 
            20              


<210>  8
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FLAG tag

<400>  8

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  9
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  StrepII tag

<400>  9

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  10
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker sequence

<400>  10

Ser Gly Ala Gly Gly Ser Gly Gly Ser Ser Gly Ser Asp Gly Ala Ser 
1               5                   10                  15      


Gly Ser 
        


<210>  11
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker sequence

<400>  11

Ser Gly Ala Gly Gly Ser Gly Gly Ser Ser Gly Ser Asp Gly Ala Ser 
1               5                   10                  15      


<210>  12
<211>  61
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine TIE XVIII

<400>  12

Gly Gln Val Arg Ile Trp Ala Thr Tyr Gln Thr Met Leu Asp Lys Ile 
1               5                   10                  15      


Arg Glu Val Pro Glu Gly Trp Leu Ile Phe Val Ala Glu Arg Glu Glu 
            20                  25                  30          


Leu Tyr Val Arg Val Arg Asn Gly Phe Arg Lys Val Leu Leu Glu Ala 
        35                  40                  45              


Arg Thr Ala Leu Leu Arg Gly Thr Gly Asn Glu Val Ala 
    50                  55                  60      


<210>  13
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer FwCMV

<400>  13
cgcaaatggg cggtaggcgt g                                                 21


<210>  14
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer RvBGH

<400>  14
tagaaggcac agtcgagg                                                     18


