               SEQUENCE LISTING

<110> Boehringer Ingelheim International GmbH

<120> Multi-specific binding proteins for cancer treatment

<130> 12-0431-WO-1

<160> 265

<170> BiSSAP 1.2

<210> 1
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3# 1LCCDR1

<400> 1
Arg Ala Ser Gln Ser Val Ser Ser Asn Phe Leu Val 
1               5                   10          

<210> 2
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#1 LCCDR2

<400> 2
Gly Ala Ser Thr Arg Ala Ser 
1               5           

<210> 3
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#1 LCCDR3

<400> 3
Gln Gln Tyr Gly Asp Ser Pro Tyr Thr 
1               5                   

<210> 4
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#1 HCCDR1

<400> 4
Gly Asn Thr Phe Thr Asn Tyr Tyr Met His 
1               5                   10  

<210> 5
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#1 HCCDR2

<400> 5
Ile Ile Asp Pro Ser Val Gly Ser Lys Ser Tyr Ala Gln Lys Phe Leu 
1               5                   10                  15      
Gly 
    

<210> 6
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#1 HCCDR3

<400> 6
Ala Gly Lys Arg Phe Gly Glu Ser Tyr Phe Asp Tyr 
1               5                   10          

<210> 7
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#2 LCCDR1

<400> 7
Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Ala 
1               5                   10      

<210> 8
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#2 LCCDR1

<400> 8
Ala Ala Ser Ser Leu Gln Ser 
1               5           

<210> 9
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#2 LCCDR1

<400> 9
Leu Gln His Asn Ser Ser Pro Tyr Thr 
1               5                   

<210> 10
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#2 HCCDR1

<400> 10
Gly Tyr Thr Phe Thr Ser Tyr Tyr Met His 
1               5                   10  

<210> 11
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#2 HCCDR2

<400> 11
Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 12
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#2 HCCDR3

<400> 12
Gly Glu Ala Val Gly Gly Asn Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15  

<210> 13
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#3 LCCDR1

<400> 13
Arg Ala Ser Gln Gly Ile Ser Asn Tyr Leu Val 
1               5                   10      

<210> 14
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#3 LCCDR2

<400> 14
Ala Val Ser Ser Leu Tyr Ser 
1               5           

<210> 15
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#3 LCCDR3

<400> 15
Leu Gln His Asp Ser Tyr Pro Tyr Thr 
1               5                   

<210> 16
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#3 HCCDR1

<400> 16
Gly Tyr Thr Phe Thr Ser Tyr Tyr Val His 
1               5                   10  

<210> 17
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#3 HCCDR2

<400> 17
Ile Ile Asn Pro Gly Gly Gly Thr Thr Ser Tyr Ala Gln Lys Phe Leu 
1               5                   10                  15      
Gly 
    

<210> 18
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#3 HCCDR3

<400> 18
Gly Glu Ala Val Thr Gly Asn Tyr Phe Tyr Tyr Gly Met Asp Val 
1               5                   10                  15  

<210> 19
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#4 LCCDR1

<400> 19
Arg Ala Ser Lys Ser Val Ser Ser Phe Gly Tyr Ser Phe Met His 
1               5                   10                  15  

<210> 20
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#4 LCCDR2

<400> 20
Leu Ala Ser Asn Leu Glu Ser 
1               5           

<210> 21
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#4 LCCDR3

<400> 21
Gln His Ser Arg Glu Leu Pro Trp Thr 
1               5                   

<210> 22
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#4 HCCDR1

<400> 22
Val Tyr Thr Phe Thr Ser Tyr Phe Met Tyr 
1               5                   10  

<210> 23
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#4 HCCDR2

<400> 23
Glu Ile Ser Pro Thr Asn Gly Asn Ser Asn Leu Asn Glu Arg Phe Lys 
1               5                   10                  15      
Asn 
    

<210> 24
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#4 HCCDR3

<400> 24
Gly Gly Asp Gly Tyr Leu Asp Tyr 
1               5               

<210> 25
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#5 LCCDR1

<400> 25
Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      

<210> 26
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#5 LCCDR2

<400> 26
Asp Ala Ser Asn Leu Glu Thr 
1               5           

<210> 27
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#5 LCCDR3

<400> 27
Gln Gln Tyr Asp Asn Leu Pro Thr Trp Thr 
1               5                   10  

<210> 28
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#5 HCCDR1

<400> 28
Gly Phe Thr Phe Thr Gly Tyr Tyr Ile His 
1               5                   10  

<210> 29
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#5 HCCDR2

<400> 29
Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 30
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#5 HCCDR3

<400> 30
Gly Trp Asp Tyr 
1               

<210> 31
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#6 LCCDR1

<400> 31
Arg Ala Ser Gln Asp Ile Ser Asn Tyr Phe Ala 
1               5                   10      

<210> 32
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#6 LCCDR2

<400> 32
Ala Ala Ser Thr Leu Gln Ser 
1               5           

<210> 33
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#6 LCCDR3

<400> 33
Gln Gln Leu Asn Ser Tyr Pro Tyr Thr 
1               5                   

<210> 34
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#6 HCCDR1

<400> 34
Gly Gly Ser Ile Ser Ser Tyr Phe Trp Ser 
1               5                   10  

<210> 35
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#6 HCCDR2

<400> 35
Arg Ile Tyr Thr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Asn Ser 
1               5                   10                  15      



<210> 36
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#6 HCCDR3

<400> 36
Arg Gly Asp Trp Gly Gly Phe Asp Ile 
1               5                   

<210> 37
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#1 VL

<400> 37
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          
Phe Leu Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu 
        35                  40                  45              
Ile Tyr Gly Ala Ser Thr Arg Ala Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Gly Asp Ser Pro 
                85                  90                  95      
Tyr Thr Phe Gly Gln Gly Thr Thr Leu Glu Ile Lys 
            100                 105             

<210> 38
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#1 VH

<400> 38
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asn Thr Phe Thr Asn Tyr 
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Pro Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ile Ile Asp Pro Ser Val Gly Ser Lys Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Leu Gly Arg Val Thr Ile Ala Arg Asp Thr Ser Thr Ser Thr Val Phe 
65                  70                  75                  80  
Leu Asp Leu Tyr Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Arg Ala Gly Lys Arg Phe Gly Glu Ser Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210> 39
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#2 VL

<400> 39
Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          
Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Glu Pro Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Val Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Ser Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 40
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#2 VH

<400> 40
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Glu Ala Val Gly Gly Asn Tyr Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 

<210> 41
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#3 VL

<400> 41
Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          
Leu Val Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              
Tyr Ala Val Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asp Ser Tyr Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 42
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#3 VH

<400> 42
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Tyr Val His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Val Ile Ile Asn Pro Gly Gly Gly Thr Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Leu Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Lys Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Glu Ala Val Thr Gly Asn Tyr Phe Tyr Tyr Gly Met Asp 
            100                 105                 110         
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 

<210> 43
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#4 VL

<400> 43
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Ser Phe 
            20                  25                  30          
Gly Tyr Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  
Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      
Glu Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     

<210> 44
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#4 VH

<400> 44
Gln Val Gln Leu Gln Gln Ser Gly Thr Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Val Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Phe Met Tyr Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Ser Pro Thr Asn Gly Asn Ser Asn Leu Asn Glu Arg Phe 
    50                  55                  60                  
Lys Asn Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Gly Gly Asp Gly Tyr Leu Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         
Leu Thr Val Ser Ser 
        115         

<210> 45
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#5 VL

<400> 45
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Val Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Thr 
                85                  90                  95      
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             

<210> 46
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#5 VH

<400> 46
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Gly Tyr 
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Ser Ser Ile Asn Thr Ala Phe 
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Gly Trp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser 
    

<210> 47
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#6 VL

<400> 47
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Thr Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          
Phe Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Gly Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 48
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#6 VH

<400> 48
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          
Phe Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Arg Ile Tyr Thr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Asn 
    50                  55                  60                  
Ser Arg Leu Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Arg Gly Asp Trp Gly Gly Phe Asp Ile Trp Gly Gln Gly Thr Val 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 49
<211> 477
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#1 scFab

<400> 49
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          
Phe Leu Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu 
        35                  40                  45              
Ile Tyr Gly Ala Ser Thr Arg Ala Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Gly Asp Ser Pro 
                85                  90                  95      
Tyr Thr Phe Gly Gln Gly Thr Thr Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu Gly Lys Ser 
    210                 215                 220                 
Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly 
225                 230                 235                 240 
Ser Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser Gln Val Gln 
                245                 250                 255     
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys 
            260                 265                 270         
Val Ser Cys Lys Ala Ser Gly Asn Thr Phe Thr Asn Tyr Tyr Met His 
        275                 280                 285             
Trp Val Arg Gln Ala Pro Gly Pro Gly Leu Glu Trp Met Gly Ile Ile 
    290                 295                 300                 
Asp Pro Ser Val Gly Ser Lys Ser Tyr Ala Gln Lys Phe Leu Gly Arg 
305                 310                 315                 320 
Val Thr Ile Ala Arg Asp Thr Ser Thr Ser Thr Val Phe Leu Asp Leu 
                325                 330                 335     
Tyr Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg Ala 
            340                 345                 350         
Gly Lys Arg Phe Gly Glu Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
        355                 360                 365             
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    370                 375                 380                 
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
385                 390                 395                 400 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                405                 410                 415     
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            420                 425                 430         
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        435                 440                 445             
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    450                 455                 460                 
Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
465                 470                 475         

<210> 50
<211> 479
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#2 scFab

<400> 50
Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          
Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Glu Pro Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Val Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Ser Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu Gly Lys Ser Ser 
    210                 215                 220                 
Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly Ser 
225                 230                 235                 240 
Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser Gln Val Gln Leu 
                245                 250                 255     
Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
            260                 265                 270         
Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Tyr Met His Trp 
        275                 280                 285             
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ile Ile Asn 
    290                 295                 300                 
Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val 
305                 310                 315                 320 
Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser 
                325                 330                 335     
Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Glu 
            340                 345                 350         
Ala Val Gly Gly Asn Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln 
        355                 360                 365             
Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    370                 375                 380                 
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
385                 390                 395                 400 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                405                 410                 415     
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            420                 425                 430         
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        435                 440                 445             
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    450                 455                 460                 
Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
465                 470                 475                 

<210> 51
<211> 479
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#3 scFab

<400> 51
Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          
Leu Val Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              
Tyr Ala Val Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asp Ser Tyr Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu Gly Lys Ser Ser 
    210                 215                 220                 
Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly Ser 
225                 230                 235                 240 
Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser Gln Val Gln Leu 
                245                 250                 255     
Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
            260                 265                 270         
Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Tyr Val His Trp 
        275                 280                 285             
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Val Ile Ile Asn 
    290                 295                 300                 
Pro Gly Gly Gly Thr Thr Ser Tyr Ala Gln Lys Phe Leu Gly Arg Val 
305                 310                 315                 320 
Thr Met Thr Arg Asp Thr Ser Thr Asn Thr Val Tyr Met Glu Leu Lys 
                325                 330                 335     
Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Glu 
            340                 345                 350         
Ala Val Thr Gly Asn Tyr Phe Tyr Tyr Gly Met Asp Val Trp Gly Gln 
        355                 360                 365             
Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    370                 375                 380                 
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
385                 390                 395                 400 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                405                 410                 415     
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            420                 425                 430         
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        435                 440                 445             
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    450                 455                 460                 
Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
465                 470                 475                 

<210> 52
<211> 476
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#4 scFab

<400> 52
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Ser Phe 
            20                  25                  30          
Gly Tyr Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  
Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      
Glu Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu 
    210                 215                 220                 
Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys 
225                 230                 235                 240 
Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser 
                245                 250                 255     
Gln Val Gln Leu Gln Gln Ser Gly Thr Glu Leu Val Lys Pro Gly Ala 
            260                 265                 270         
Ser Val Lys Leu Ser Cys Lys Ala Ser Val Tyr Thr Phe Thr Ser Tyr 
        275                 280                 285             
Phe Met Tyr Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
    290                 295                 300                 
Gly Glu Ile Ser Pro Thr Asn Gly Asn Ser Asn Leu Asn Glu Arg Phe 
305                 310                 315                 320 
Lys Asn Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
                325                 330                 335     
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
            340                 345                 350         
Thr Arg Gly Gly Asp Gly Tyr Leu Asp Tyr Trp Gly Gln Gly Thr Thr 
        355                 360                 365             
Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    370                 375                 380                 
Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
385                 390                 395                 400 
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                405                 410                 415     
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            420                 425                 430         
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        435                 440                 445             
Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
    450                 455                 460                 
Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
465                 470                 475     

<210> 53
<211> 469
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#5 scFab

<400> 53
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Val Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Thr 
                85                  90                  95      
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu Gly Lys Ser 
    210                 215                 220                 
Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly 
225                 230                 235                 240 
Ser Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser Gln Val Gln 
                245                 250                 255     
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys 
            260                 265                 270         
Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Gly Tyr Tyr Ile His 
        275                 280                 285             
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile 
    290                 295                 300                 
Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg 
305                 310                 315                 320 
Val Thr Met Thr Arg Asp Ser Ser Ile Asn Thr Ala Phe Met Glu Leu 
                325                 330                 335     
Ser Arg Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly 
            340                 345                 350         
Trp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        355                 360                 365             
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    370                 375                 380                 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
385                 390                 395                 400 
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                405                 410                 415     
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            420                 425                 430         
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        435                 440                 445             
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    450                 455                 460                 
Glu Pro Lys Ser Cys 
465                 

<210> 54
<211> 472
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#6 scFab

<400> 54
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Thr Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          
Phe Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Gly Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu Gly Lys Ser Ser 
    210                 215                 220                 
Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly Ser 
225                 230                 235                 240 
Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser Gln Val Gln Leu 
                245                 250                 255     
Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu 
            260                 265                 270         
Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr Phe Trp Ser Trp 
        275                 280                 285             
Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile Gly Arg Ile Tyr 
    290                 295                 300                 
Thr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Asn Ser Arg Leu Thr 
305                 310                 315                 320 
Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser 
                325                 330                 335     
Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Asp 
            340                 345                 350         
Trp Gly Gly Phe Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser 
        355                 360                 365             
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
    370                 375                 380                 
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
385                 390                 395                 400 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
                405                 410                 415     
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
            420                 425                 430         
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
        435                 440                 445             
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
    450                 455                 460                 
Lys Arg Val Glu Pro Lys Ser Cys 
465                 470         

<210> 55
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3#1 LCCDR1

<400> 55
Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  

<210> 56
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3#1 LCCDR2

<400> 56
Gly Thr Asn Lys Arg Ala Pro 
1               5           

<210> 57
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3#1 LCCDR3

<400> 57
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   

<210> 58
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3#1 HCCDR1

<400> 58
Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn 
1               5                   10  

<210> 59
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3#1 HCCDR2

<400> 59
Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      
Val Lys Asp 
            

<210> 60
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3#1 HCCDR3

<400> 60
His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr 
1               5                   10                  

<210> 61
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3#2 LCCDR1

<400> 61
Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  

<210> 62
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3#2 LCCDR2

<400> 62
Gly Thr Asn Lys Arg Ala Pro 
1               5           

<210> 63
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3#2 LCCDR3

<400> 63
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   

<210> 64
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3#2 HCCDR1

<400> 64
Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn 
1               5                   10  

<210> 65
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3#2 HCCDR2

<400> 65
Arg Ile Arg Ser Lys Tyr Ile Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      
Val Lys Asp 
            

<210> 66
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3#2 HCCDR3

<400> 66
His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr 
1               5                   10                  

<210> 67
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3#1 VL

<400> 67
Glu Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      
Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          
Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Leu Pro Arg Gly 
        35                  40                  45              
Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Val Pro Ala Arg Phe 
    50                  55                  60                  
Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  
Gln Pro Glu Asp Glu Ala Glu Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      
Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 

<210> 68
<211> 125
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3#1 VH

<400> 68
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  
Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         
Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120                 125 

<210> 69
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3#2 VL

<400> 69
Glu Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      
Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          
Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Leu Pro Arg Gly 
        35                  40                  45              
Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Val Pro Ala Arg Phe 
    50                  55                  60                  
Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  
Gln Pro Glu Asp Glu Ala Glu Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      
Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 

<210> 70
<211> 125
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3#2 VH

<400> 70
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Arg Ser Lys Tyr Ile Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  
Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         
Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120                 125 

<210> 71
<211> 481
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3#1 scFab

<400> 71
Glu Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      
Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          
Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Leu Pro Arg Gly 
        35                  40                  45              
Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Val Pro Ala Arg Phe 
    50                  55                  60                  
Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  
Gln Pro Glu Asp Glu Ala Glu Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      
Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         
Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             
Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 
Gly Ala Val Lys Val Ala Trp Lys Ala Asp Gly Ser Pro Val Asn Thr 
145                 150                 155                 160 
Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     
Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         
Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             
Val Ala Pro Ala Glu Cys Ser Gly Gly Gly Gly Ser Glu Gly Lys Ser 
    210                 215                 220                 
Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly 
225                 230                 235                 240 
Ser Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser Glu Val Gln 
                245                 250                 255     
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys 
            260                 265                 270         
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn 
        275                 280                 285             
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
    290                 295                 300                 
Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys 
305                 310                 315                 320 
Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu 
                325                 330                 335     
Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
            340                 345                 350         
Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp 
        355                 360                 365             
Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro 
    370                 375                 380                 
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
385                 390                 395                 400 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                405                 410                 415     
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            420                 425                 430         
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        435                 440                 445             
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    450                 455                 460                 
His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
465                 470                 475                 480 
Cys 
    

<210> 72
<211> 481
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3#2 scFab

<400> 72
Glu Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      
Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          
Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Leu Pro Arg Gly 
        35                  40                  45              
Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Val Pro Ala Arg Phe 
    50                  55                  60                  
Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  
Gln Pro Glu Asp Glu Ala Glu Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      
Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         
Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             
Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 
Gly Ala Val Lys Val Ala Trp Lys Ala Asp Gly Ser Pro Val Asn Thr 
145                 150                 155                 160 
Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     
Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         
Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             
Val Ala Pro Ala Glu Cys Ser Gly Gly Gly Gly Ser Glu Gly Lys Ser 
    210                 215                 220                 
Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly 
225                 230                 235                 240 
Ser Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser Glu Val Gln 
                245                 250                 255     
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys 
            260                 265                 270         
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn 
        275                 280                 285             
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
    290                 295                 300                 
Arg Ser Lys Tyr Ile Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys 
305                 310                 315                 320 
Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu 
                325                 330                 335     
Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
            340                 345                 350         
Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp 
        355                 360                 365             
Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro 
    370                 375                 380                 
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
385                 390                 395                 400 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                405                 410                 415     
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            420                 425                 430         
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        435                 440                 445             
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    450                 455                 460                 
His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
465                 470                 475                 480 
Cys 
    

<210> 73
<211> 703
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#1 chain

<400> 73
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          
Phe Leu Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu 
        35                  40                  45              
Ile Tyr Gly Ala Ser Thr Arg Ala Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Tyr Gly Asp Ser Pro 
                85                  90                  95      
Tyr Thr Phe Gly Gln Gly Thr Thr Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu Gly Lys Ser 
    210                 215                 220                 
Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly 
225                 230                 235                 240 
Ser Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser Gln Val Gln 
                245                 250                 255     
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys 
            260                 265                 270         
Val Ser Cys Lys Ala Ser Gly Asn Thr Phe Thr Asn Tyr Tyr Met His 
        275                 280                 285             
Trp Val Arg Gln Ala Pro Gly Pro Gly Leu Glu Trp Met Gly Ile Ile 
    290                 295                 300                 
Asp Pro Ser Val Gly Ser Lys Ser Tyr Ala Gln Lys Phe Leu Gly Arg 
305                 310                 315                 320 
Val Thr Ile Ala Arg Asp Thr Ser Thr Ser Thr Val Phe Leu Asp Leu 
                325                 330                 335     
Tyr Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg Ala 
            340                 345                 350         
Gly Lys Arg Phe Gly Glu Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
        355                 360                 365             
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    370                 375                 380                 
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
385                 390                 395                 400 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                405                 410                 415     
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            420                 425                 430         
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        435                 440                 445             
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    450                 455                 460                 
Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
465                 470                 475                 480 
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
                485                 490                 495     
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            500                 505                 510         
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        515                 520                 525             
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    530                 535                 540                 
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
545                 550                 555                 560 
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                565                 570                 575     
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            580                 585                 590         
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        595                 600                 605             
Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys 
    610                 615                 620                 
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
625                 630                 635                 640 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                645                 650                 655     
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            660                 665                 670         
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        675                 680                 685             
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    690                 695                 700             

<210> 74
<211> 705
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#2 chain

<400> 74
Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          
Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Glu Pro Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Val Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Ser Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu Gly Lys Ser Ser 
    210                 215                 220                 
Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly Ser 
225                 230                 235                 240 
Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser Gln Val Gln Leu 
                245                 250                 255     
Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
            260                 265                 270         
Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Tyr Met His Trp 
        275                 280                 285             
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ile Ile Asn 
    290                 295                 300                 
Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val 
305                 310                 315                 320 
Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser 
                325                 330                 335     
Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Glu 
            340                 345                 350         
Ala Val Gly Gly Asn Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln 
        355                 360                 365             
Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    370                 375                 380                 
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
385                 390                 395                 400 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                405                 410                 415     
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            420                 425                 430         
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        435                 440                 445             
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    450                 455                 460                 
Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
465                 470                 475                 480 
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
                485                 490                 495     
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            500                 505                 510         
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        515                 520                 525             
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    530                 535                 540                 
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
545                 550                 555                 560 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                565                 570                 575     
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            580                 585                 590         
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        595                 600                 605             
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    610                 615                 620                 
Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
625                 630                 635                 640 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                645                 650                 655     
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            660                 665                 670         
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        675                 680                 685             
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    690                 695                 700                 
Gly 
705 

<210> 75
<211> 705
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#3 chain

<400> 75
Asp Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          
Leu Val Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              
Tyr Ala Val Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asp Ser Tyr Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu Gly Lys Ser Ser 
    210                 215                 220                 
Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly Ser 
225                 230                 235                 240 
Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser Gln Val Gln Leu 
                245                 250                 255     
Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
            260                 265                 270         
Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Tyr Val His Trp 
        275                 280                 285             
Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Val Ile Ile Asn 
    290                 295                 300                 
Pro Gly Gly Gly Thr Thr Ser Tyr Ala Gln Lys Phe Leu Gly Arg Val 
305                 310                 315                 320 
Thr Met Thr Arg Asp Thr Ser Thr Asn Thr Val Tyr Met Glu Leu Lys 
                325                 330                 335     
Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Glu 
            340                 345                 350         
Ala Val Thr Gly Asn Tyr Phe Tyr Tyr Gly Met Asp Val Trp Gly Gln 
        355                 360                 365             
Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    370                 375                 380                 
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
385                 390                 395                 400 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                405                 410                 415     
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            420                 425                 430         
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        435                 440                 445             
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    450                 455                 460                 
Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
465                 470                 475                 480 
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
                485                 490                 495     
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            500                 505                 510         
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        515                 520                 525             
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    530                 535                 540                 
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
545                 550                 555                 560 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                565                 570                 575     
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            580                 585                 590         
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        595                 600                 605             
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    610                 615                 620                 
Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
625                 630                 635                 640 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                645                 650                 655     
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            660                 665                 670         
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        675                 680                 685             
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    690                 695                 700                 
Gly 
705 

<210> 76
<211> 702
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#4 chain

<400> 76
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Ser Phe 
            20                  25                  30          
Gly Tyr Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  
Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      
Glu Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu 
    210                 215                 220                 
Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys 
225                 230                 235                 240 
Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser 
                245                 250                 255     
Gln Val Gln Leu Gln Gln Ser Gly Thr Glu Leu Val Lys Pro Gly Ala 
            260                 265                 270         
Ser Val Lys Leu Ser Cys Lys Ala Ser Val Tyr Thr Phe Thr Ser Tyr 
        275                 280                 285             
Phe Met Tyr Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
    290                 295                 300                 
Gly Glu Ile Ser Pro Thr Asn Gly Asn Ser Asn Leu Asn Glu Arg Phe 
305                 310                 315                 320 
Lys Asn Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
                325                 330                 335     
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
            340                 345                 350         
Thr Arg Gly Gly Asp Gly Tyr Leu Asp Tyr Trp Gly Gln Gly Thr Thr 
        355                 360                 365             
Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    370                 375                 380                 
Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
385                 390                 395                 400 
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                405                 410                 415     
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            420                 425                 430         
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        435                 440                 445             
Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
    450                 455                 460                 
Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
465                 470                 475                 480 
Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
                485                 490                 495     
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            500                 505                 510         
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        515                 520                 525             
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    530                 535                 540                 
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
545                 550                 555                 560 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                565                 570                 575     
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            580                 585                 590         
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        595                 600                 605             
Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 
    610                 615                 620                 
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
625                 630                 635                 640 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                645                 650                 655     
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            660                 665                 670         
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        675                 680                 685             
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    690                 695                 700         

<210> 77
<211> 695
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#5 chain

<400> 77
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Val Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Thr 
                85                  90                  95      
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu Gly Lys Ser 
    210                 215                 220                 
Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly 
225                 230                 235                 240 
Ser Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser Gln Val Gln 
                245                 250                 255     
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys 
            260                 265                 270         
Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Gly Tyr Tyr Ile His 
        275                 280                 285             
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile 
    290                 295                 300                 
Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln Gly Arg 
305                 310                 315                 320 
Val Thr Met Thr Arg Asp Ser Ser Ile Asn Thr Ala Phe Met Glu Leu 
                325                 330                 335     
Ser Arg Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly 
            340                 345                 350         
Trp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        355                 360                 365             
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    370                 375                 380                 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
385                 390                 395                 400 
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                405                 410                 415     
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            420                 425                 430         
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        435                 440                 445             
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    450                 455                 460                 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
465                 470                 475                 480 
Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                485                 490                 495     
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            500                 505                 510         
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        515                 520                 525             
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    530                 535                 540                 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
545                 550                 555                 560 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                565                 570                 575     
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            580                 585                 590         
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
        595                 600                 605             
Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    610                 615                 620                 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
625                 630                 635                 640 
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                645                 650                 655     
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            660                 665                 670         
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        675                 680                 685             
Ser Leu Ser Leu Ser Pro Gly 
    690                 695 

<210> 78
<211> 698
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#6 chain

<400> 78
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Thr Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          
Phe Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Gly Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu Gly Lys Ser Ser 
    210                 215                 220                 
Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly Ser 
225                 230                 235                 240 
Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser Gln Val Gln Leu 
                245                 250                 255     
Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu 
            260                 265                 270         
Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr Phe Trp Ser Trp 
        275                 280                 285             
Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile Gly Arg Ile Tyr 
    290                 295                 300                 
Thr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Asn Ser Arg Leu Thr 
305                 310                 315                 320 
Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser 
                325                 330                 335     
Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Asp 
            340                 345                 350         
Trp Gly Gly Phe Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser 
        355                 360                 365             
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
    370                 375                 380                 
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
385                 390                 395                 400 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
                405                 410                 415     
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
            420                 425                 430         
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
        435                 440                 445             
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
    450                 455                 460                 
Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
465                 470                 475                 480 
Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
                485                 490                 495     
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            500                 505                 510         
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        515                 520                 525             
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    530                 535                 540                 
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
545                 550                 555                 560 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                565                 570                 575     
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            580                 585                 590         
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
        595                 600                 605             
Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 
    610                 615                 620                 
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
625                 630                 635                 640 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                645                 650                 655     
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            660                 665                 670         
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        675                 680                 685             
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    690                 695             

<210> 79
<211> 707
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3#1 chain

<400> 79
Glu Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      
Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          
Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Leu Pro Arg Gly 
        35                  40                  45              
Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Val Pro Ala Arg Phe 
    50                  55                  60                  
Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  
Gln Pro Glu Asp Glu Ala Glu Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      
Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         
Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             
Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 
Gly Ala Val Lys Val Ala Trp Lys Ala Asp Gly Ser Pro Val Asn Thr 
145                 150                 155                 160 
Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     
Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         
Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             
Val Ala Pro Ala Glu Cys Ser Gly Gly Gly Gly Ser Glu Gly Lys Ser 
    210                 215                 220                 
Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly 
225                 230                 235                 240 
Ser Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser Glu Val Gln 
                245                 250                 255     
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys 
            260                 265                 270         
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn 
        275                 280                 285             
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
    290                 295                 300                 
Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys 
305                 310                 315                 320 
Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu 
                325                 330                 335     
Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
            340                 345                 350         
Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp 
        355                 360                 365             
Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro 
    370                 375                 380                 
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
385                 390                 395                 400 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                405                 410                 415     
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            420                 425                 430         
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        435                 440                 445             
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    450                 455                 460                 
His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
465                 470                 475                 480 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
                485                 490                 495     
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            500                 505                 510         
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        515                 520                 525             
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    530                 535                 540                 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
545                 550                 555                 560 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                565                 570                 575     
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            580                 585                 590         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        595                 600                 605             
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    610                 615                 620                 
Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
625                 630                 635                 640 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                645                 650                 655     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr 
            660                 665                 670         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        675                 680                 685             
Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu 
    690                 695                 700                 
Ser Pro Gly 
705         

<210> 80
<211> 707
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3#2 chain

<400> 80
Glu Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      
Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          
Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Leu Pro Arg Gly 
        35                  40                  45              
Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Val Pro Ala Arg Phe 
    50                  55                  60                  
Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  
Gln Pro Glu Asp Glu Ala Glu Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      
Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         
Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             
Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 
Gly Ala Val Lys Val Ala Trp Lys Ala Asp Gly Ser Pro Val Asn Thr 
145                 150                 155                 160 
Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     
Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         
Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             
Val Ala Pro Ala Glu Cys Ser Gly Gly Gly Gly Ser Glu Gly Lys Ser 
    210                 215                 220                 
Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly 
225                 230                 235                 240 
Ser Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser Glu Val Gln 
                245                 250                 255     
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys 
            260                 265                 270         
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn 
        275                 280                 285             
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
    290                 295                 300                 
Arg Ser Lys Tyr Ile Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys 
305                 310                 315                 320 
Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu 
                325                 330                 335     
Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
            340                 345                 350         
Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp 
        355                 360                 365             
Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro 
    370                 375                 380                 
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
385                 390                 395                 400 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                405                 410                 415     
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            420                 425                 430         
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        435                 440                 445             
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    450                 455                 460                 
His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
465                 470                 475                 480 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
                485                 490                 495     
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            500                 505                 510         
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        515                 520                 525             
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    530                 535                 540                 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
545                 550                 555                 560 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                565                 570                 575     
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            580                 585                 590         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        595                 600                 605             
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    610                 615                 620                 
Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
625                 630                 635                 640 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                645                 650                 655     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr 
            660                 665                 670         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        675                 680                 685             
Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu 
    690                 695                 700                 
Ser Pro Gly 
705         

<210> 81
<211> 226
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fcdomain* (IgG1)

<400> 81
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 
Pro Gly 
225     

<210> 82
<211> 226
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fcknobdomain (IgG1,LALA)

<400> 82
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 
Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 
Pro Gly 
225     

<210> 83
<211> 226
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fcholedomain (IgG1,RF/LALA)

<400> 83
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 
Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             
His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 
Pro Gly 
225     

<210> 84
<211> 228
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fcdomain (IgG4Pro)

<400> 84
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              
Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         
Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             
Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         
Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 
Leu Ser Leu Gly 
225             

<210> 85
<211> 228
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fcknobdomain(IgG4Pro)

<400> 85
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              
Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         
Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             
Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 
Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         
Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 
Leu Ser Leu Gly 
225             

<210> 86
<211> 228
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fcholedomain(IgG4Pro,RF)

<400> 86
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              
Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         
Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             
Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 
Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Arg Leu 
            180                 185                 190         
Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             
Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 
Leu Ser Leu Gly 
225             

<210> 87
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> constantregionofakappalightchain

<400> 87
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         

<210> 88
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> constantregionofalambdalightchain

<400> 88
Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      
Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          
Phe Tyr Pro Gly Ala Val Lys Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              
Val Asn Thr Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  
Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  
Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      
Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
            100                 105     

<210> 89
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 89
Gly Gly Gly Gly Ser Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser 
1               5                   10                  15      
Lys Ser Thr Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser 
            20                  25                  30          
Thr Gly Gly Gly Gly Ser 
        35              

<210> 90
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 90
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10                  15      
Gly Gly Gly Gly Gly Ser 
            20          

<210> 91
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 91
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      
Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser 
            20                  25      

<210> 92
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 92
Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser 
            20                  25                  30  

<210> 93
<211> 34
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 93
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  30          
Gly Ser 
        

<210> 94
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 94
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      
Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30          
Gly Gly Gly Gly Gly Ser 
        35              

<210> 95
<211> 42
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker

<400> 95
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      
Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly 
            20                  25                  30          
Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40          

<210> 96
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3#3 LCCDR1

<400> 96
Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  

<210> 97
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3#3 LCCDR2

<400> 97
Gly Thr Asn Lys Arg Ala Pro 
1               5           

<210> 98
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3#3 LCCDR3

<400> 98
Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   

<210> 99
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3#3 HCCDR1

<400> 99
Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn 
1               5                   10  

<210> 100
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3#3 HCCDR2

<400> 100
Arg Ile Arg Ser Lys Tyr Ala Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      
Val Lys Asp 
            

<210> 101
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3#3 HCCDR3

<400> 101
His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr 
1               5                   10                  

<210> 102
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3#3 VL

<400> 102
Glu Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      
Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          
Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Leu Pro Arg Gly 
        35                  40                  45              
Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Val Pro Ala Arg Phe 
    50                  55                  60                  
Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  
Gln Pro Glu Asp Glu Ala Glu Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      
Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 

<210> 103
<211> 125
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3#3 HL

<400> 103
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Arg Ile Arg Ser Lys Tyr Ala Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  
Ala Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         
Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120                 125 

<210> 104
<211> 481
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3#3 scFab

<400> 104
Glu Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      
Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          
Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Leu Pro Arg Gly 
        35                  40                  45              
Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Val Pro Ala Arg Phe 
    50                  55                  60                  
Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  
Gln Pro Glu Asp Glu Ala Glu Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      
Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         
Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             
Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 
Gly Ala Val Lys Val Ala Trp Lys Ala Asp Gly Ser Pro Val Asn Thr 
145                 150                 155                 160 
Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     
Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         
Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             
Val Ala Pro Ala Glu Cys Ser Gly Gly Gly Gly Ser Glu Gly Lys Ser 
    210                 215                 220                 
Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly 
225                 230                 235                 240 
Ser Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser Glu Val Gln 
                245                 250                 255     
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys 
            260                 265                 270         
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn 
        275                 280                 285             
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
    290                 295                 300                 
Arg Ser Lys Tyr Ala Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys 
305                 310                 315                 320 
Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu 
                325                 330                 335     
Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
            340                 345                 350         
Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp 
        355                 360                 365             
Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro 
    370                 375                 380                 
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
385                 390                 395                 400 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                405                 410                 415     
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            420                 425                 430         
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        435                 440                 445             
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    450                 455                 460                 
His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
465                 470                 475                 480 
Cys 
    

<210> 105
<211> 707
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3#3 chain

<400> 105
Glu Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      
Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          
Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Leu Pro Arg Gly 
        35                  40                  45              
Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Trp Val Pro Ala Arg Phe 
    50                  55                  60                  
Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  
Gln Pro Glu Asp Glu Ala Glu Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      
Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         
Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             
Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 
Gly Ala Val Lys Val Ala Trp Lys Ala Asp Gly Ser Pro Val Asn Thr 
145                 150                 155                 160 
Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     
Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         
Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             
Val Ala Pro Ala Glu Cys Ser Gly Gly Gly Gly Ser Glu Gly Lys Ser 
    210                 215                 220                 
Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly 
225                 230                 235                 240 
Ser Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser Glu Val Gln 
                245                 250                 255     
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys 
            260                 265                 270         
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Asn 
        275                 280                 285             
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
    290                 295                 300                 
Arg Ser Lys Tyr Ala Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys 
305                 310                 315                 320 
Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr Leu 
                325                 330                 335     
Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Val 
            340                 345                 350         
Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp 
        355                 360                 365             
Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro 
    370                 375                 380                 
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
385                 390                 395                 400 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                405                 410                 415     
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            420                 425                 430         
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        435                 440                 445             
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    450                 455                 460                 
His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
465                 470                 475                 480 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
                485                 490                 495     
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            500                 505                 510         
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        515                 520                 525             
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    530                 535                 540                 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
545                 550                 555                 560 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                565                 570                 575     
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            580                 585                 590         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        595                 600                 605             
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    610                 615                 620                 
Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
625                 630                 635                 640 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                645                 650                 655     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr 
            660                 665                 670         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        675                 680                 685             
Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu 
    690                 695                 700                 
Ser Pro Gly 
705         

<210> 106
<211> 476
<212> PRT
<213> Artificial Sequence

<220> 
<223> HuDLL3(ECD)-His

<400> 106
Ala Gly Val Phe Glu Leu Gln Ile His Ser Phe Gly Pro Gly Pro Gly 
1               5                   10                  15      
Pro Gly Ala Pro Arg Ser Pro Cys Ser Ala Arg Leu Pro Cys Arg Leu 
            20                  25                  30          
Phe Phe Arg Val Cys Leu Lys Pro Gly Leu Ser Glu Glu Ala Ala Glu 
        35                  40                  45              
Ser Pro Cys Ala Leu Gly Ala Ala Leu Ser Ala Arg Gly Pro Val Tyr 
    50                  55                  60                  
Thr Glu Gln Pro Gly Ala Pro Ala Pro Asp Leu Pro Leu Pro Asp Gly 
65                  70                  75                  80  
Leu Leu Gln Val Pro Phe Arg Asp Ala Trp Pro Gly Thr Phe Ser Phe 
                85                  90                  95      
Ile Ile Glu Thr Trp Arg Glu Glu Leu Gly Asp Gln Ile Gly Gly Pro 
            100                 105                 110         
Ala Trp Ser Leu Leu Ala Arg Val Ala Gly Arg Arg Arg Leu Ala Ala 
        115                 120                 125             
Gly Gly Pro Trp Ala Arg Asp Ile Gln Arg Ala Gly Ala Trp Glu Leu 
    130                 135                 140                 
Arg Phe Ser Tyr Arg Ala Arg Cys Glu Pro Pro Ala Val Gly Thr Ala 
145                 150                 155                 160 
Cys Thr Arg Leu Cys Arg Pro Arg Ser Ala Pro Ser Arg Cys Gly Pro 
                165                 170                 175     
Gly Leu Arg Pro Cys Ala Pro Leu Glu Asp Glu Cys Glu Ala Pro Leu 
            180                 185                 190         
Val Cys Arg Ala Gly Cys Ser Pro Glu His Gly Phe Cys Glu Gln Pro 
        195                 200                 205             
Gly Glu Cys Arg Cys Leu Glu Gly Trp Thr Gly Pro Leu Cys Thr Val 
    210                 215                 220                 
Pro Val Ser Thr Ser Ser Cys Leu Ser Pro Arg Gly Pro Ser Ser Ala 
225                 230                 235                 240 
Thr Thr Gly Cys Leu Val Pro Gly Pro Gly Pro Cys Asp Gly Asn Pro 
                245                 250                 255     
Cys Ala Asn Gly Gly Ser Cys Ser Glu Thr Pro Arg Ser Phe Glu Cys 
            260                 265                 270         
Thr Cys Pro Arg Gly Phe Tyr Gly Leu Arg Cys Glu Val Ser Gly Val 
        275                 280                 285             
Thr Cys Ala Asp Gly Pro Cys Phe Asn Gly Gly Leu Cys Val Gly Gly 
    290                 295                 300                 
Ala Asp Pro Asp Ser Ala Tyr Ile Cys His Cys Pro Pro Gly Phe Gln 
305                 310                 315                 320 
Gly Ser Asn Cys Glu Lys Arg Val Asp Arg Cys Ser Leu Gln Pro Cys 
                325                 330                 335     
Arg Asn Gly Gly Leu Cys Leu Asp Leu Gly His Ala Leu Arg Cys Arg 
            340                 345                 350         
Cys Arg Ala Gly Phe Ala Gly Pro Arg Cys Glu His Asp Leu Asp Asp 
        355                 360                 365             
Cys Ala Gly Arg Ala Cys Ala Asn Gly Gly Thr Cys Val Glu Gly Gly 
    370                 375                 380                 
Gly Ala His Arg Cys Ser Cys Ala Leu Gly Phe Gly Gly Arg Asp Cys 
385                 390                 395                 400 
Arg Glu Arg Ala Asp Pro Cys Ala Ala Arg Pro Cys Ala His Gly Gly 
                405                 410                 415     
Arg Cys Tyr Ala His Phe Ser Gly Leu Val Cys Ala Cys Ala Pro Gly 
            420                 425                 430         
Tyr Met Gly Ala Arg Cys Glu Phe Pro Val His Pro Asp Gly Ala Ser 
        435                 440                 445             
Ala Leu Pro Ala Ala Pro Pro Gly Leu Arg Pro Gly Asp Pro Gln Arg 
    450                 455                 460                 
Tyr Leu Ala Gly Ser Ala His His His His His His 
465                 470                 475     

<210> 107
<211> 476
<212> PRT
<213> Artificial Sequence

<220> 
<223> CynoDLL3(ECD)-His

<400> 107
Ala Gly Val Phe Glu Leu Gln Ile His Ser Phe Gly Pro Gly Pro Gly 
1               5                   10                  15      
Pro Gly Ala Pro Arg Ser Pro Cys Ser Ala Arg Gly Pro Cys Arg Leu 
            20                  25                  30          
Phe Phe Arg Val Cys Leu Lys Pro Gly Leu Ser Glu Glu Ala Ala Glu 
        35                  40                  45              
Ser Pro Cys Ala Leu Gly Ala Ala Leu Ser Ala Arg Gly Pro Val Tyr 
    50                  55                  60                  
Thr Glu Gln Pro Glu Ala Pro Ala Pro Asp Leu Pro Leu Pro Asn Gly 
65                  70                  75                  80  
Leu Leu Gln Val Pro Phe Arg Asp Ala Trp Pro Gly Thr Phe Ser Leu 
                85                  90                  95      
Ile Ile Glu Thr Trp Arg Glu Glu Leu Gly Asp Gln Ile Gly Gly Pro 
            100                 105                 110         
Ala Trp Ser Leu Leu Ala Arg Val Thr Arg Arg Arg Arg Leu Ala Ala 
        115                 120                 125             
Gly Gly Pro Trp Ala Arg Asp Ile Gln Arg Ala Gly Ala Trp Glu Leu 
    130                 135                 140                 
Arg Phe Ser Tyr Arg Ala Arg Cys Glu Leu Pro Ala Val Gly Thr Ala 
145                 150                 155                 160 
Cys Thr Arg Leu Cys Arg Pro Arg Ser Ala Pro Ser Arg Cys Gly Pro 
                165                 170                 175     
Gly Leu Arg Pro Cys Ala Pro Leu Glu Asp Glu Cys Glu Ala Pro Pro 
            180                 185                 190         
Val Cys Arg Ala Gly Cys Ser Leu Glu His Gly Phe Cys Glu Gln Pro 
        195                 200                 205             
Gly Glu Cys Arg Cys Leu Glu Gly Trp Thr Gly Pro Leu Cys Met Val 
    210                 215                 220                 
Pro Val Ser Thr Ser Ser Cys Leu Gly Leu Arg Gly Pro Ser Ser Thr 
225                 230                 235                 240 
Thr Thr Gly Cys Leu Val Pro Gly Pro Gly Pro Cys Asp Gly Asn Pro 
                245                 250                 255     
Cys Ala Asn Gly Gly Ser Cys Ser Glu Thr Pro Gly Ser Phe Glu Cys 
            260                 265                 270         
Thr Cys Pro Arg Gly Phe Tyr Gly Leu Arg Cys Glu Val Ser Gly Val 
        275                 280                 285             
Thr Cys Ala Asp Gly Pro Cys Phe Asn Gly Gly Leu Cys Val Gly Gly 
    290                 295                 300                 
Ala Asp Pro Asp Ser Ala Tyr Ile Cys His Cys Pro Pro Gly Phe Gln 
305                 310                 315                 320 
Gly Ser Asn Cys Glu Lys Arg Val Asp Arg Cys Ser Leu Gln Pro Cys 
                325                 330                 335     
Arg Asn Gly Gly Leu Cys Leu Asp Leu Gly His Ala Leu Arg Cys Arg 
            340                 345                 350         
Cys Arg Ala Gly Phe Ala Gly Pro Arg Cys Glu His Asp Leu Asp Asp 
        355                 360                 365             
Cys Ala Gly Arg Ala Cys Ala Asn Gly Gly Thr Cys Val Glu Gly Gly 
    370                 375                 380                 
Gly Ala His Arg Cys Ser Cys Ala Leu Gly Phe Gly Gly Arg Asn Cys 
385                 390                 395                 400 
Arg Glu Arg Ala Asp Pro Cys Ala Ala Arg Pro Cys Ala His Gly Gly 
                405                 410                 415     
Arg Cys Tyr Ala His Phe Ser Gly Leu Val Cys Ala Cys Ala Pro Gly 
            420                 425                 430         
Tyr Met Gly Ala Arg Cys Glu Phe Pro Val His Pro Asp Gly Val Ser 
        435                 440                 445             
Ala Leu Pro Ala Ala Pro Pro Gly Leu Arg Pro Gly Asp Pro Gln Arg 
    450                 455                 460                 
Tyr Leu Ala Gly Ser Ala His His His His His His 
465                 470                 475     

<210> 108
<211> 487
<212> PRT
<213> Artificial Sequence

<220> 
<223> HuCD3E+G-HuFc-His

<400> 108
Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys 
1               5                   10                  15      
Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro 
            20                  25                  30          
Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp 
        35                  40                  45              
Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys 
    50                  55                  60                  
Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg 
65                  70                  75                  80  
Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg 
                85                  90                  95      
Val Cys Glu Asn Cys Met Glu Met Asp Gly Gly Gly Ser Gly Gly Gly 
            100                 105                 110         
Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gln Ser Ile Lys Gly Asn His Leu Val Lys Val Tyr Asp 
    130                 135                 140                 
Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala Glu Ala Lys 
145                 150                 155                 160 
Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe Leu Thr Glu 
                165                 170                 175     
Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp Pro Arg Gly 
            180                 185                 190         
Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro Leu Gln Val 
        195                 200                 205             
Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala Ala Thr Ile 
    210                 215                 220                 
Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
225                 230                 235                 240 
Gly Gly Ser Gly Gly Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                245                 250                 255     
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            260                 265                 270         
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ala Gly Ser 
465                 470                 475                 480 
Ala His His His His His His 
                485         

<210> 109
<211> 477
<212> PRT
<213> Artificial Sequence

<220> 
<223> CynoCD3E+G-Fc-His

<400> 109
Gln Asp Gly Asn Glu Glu Met Gly Ser Ile Thr Gln Thr Pro Tyr Gln 
1               5                   10                  15      
Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Ser Gln His Leu 
            20                  25                  30          
Gly Ser Glu Ala Gln Trp Gln His Asn Gly Lys Asn Lys Gly Asp Ser 
        35                  40                  45              
Gly Asp Gln Leu Phe Leu Pro Glu Phe Ser Glu Met Glu Gln Ser Gly 
    50                  55                  60                  
Tyr Tyr Val Cys Tyr Pro Arg Gly Ser Asn Pro Glu Asp Ala Ser His 
65                  70                  75                  80  
His Leu Tyr Leu Lys Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp 
                85                  90                  95      
Val Met Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
            100                 105                 110         
Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gln Ser Phe Glu 
        115                 120                 125             
Glu Asn Arg Lys Leu Asn Val Tyr Asn Gln Glu Asp Gly Ser Val Leu 
    130                 135                 140                 
Leu Thr Cys His Val Lys Asn Thr Asn Ile Thr Trp Phe Lys Glu Gly 
145                 150                 155                 160 
Lys Met Ile Asp Ile Leu Thr Ala His Lys Asn Lys Trp Asn Leu Gly 
                165                 170                 175     
Ser Asn Thr Lys Asp Pro Arg Gly Val Tyr Gln Cys Lys Gly Ser Lys 
            180                 185                 190         
Asp Lys Ser Lys Thr Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys 
        195                 200                 205             
Ile Glu Leu Asn Ala Ala Thr Gly Gly Ser Gly Gly Ser Gly Gly Ser 
    210                 215                 220                 
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Glu Pro Lys Ser Cys 
225                 230                 235                 240 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    370                 375                 380                 
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 
Pro Gly Lys Ala Gly Ser Ala His His His His His His 
465                 470                 475         

<210> 110
<211> 626
<212> PRT
<213> Artificial Sequence

<220> 
<223> FLAG-tagged human DLL3 full length

<400> 110
Met Val Ser Pro Arg Met Ser Gly Leu Leu Ser Gln Thr Val Ile Leu 
1               5                   10                  15      
Ala Leu Ile Phe Leu Pro Gln Thr Arg Pro Asp Tyr Lys Asp Asp Asp 
            20                  25                  30          
Asp Lys Ala Gly Val Phe Glu Leu Gln Ile His Ser Phe Gly Pro Gly 
        35                  40                  45              
Pro Gly Pro Gly Ala Pro Arg Ser Pro Cys Ser Ala Arg Leu Pro Cys 
    50                  55                  60                  
Arg Leu Phe Phe Arg Val Cys Leu Lys Pro Gly Leu Ser Glu Glu Ala 
65                  70                  75                  80  
Ala Glu Ser Pro Cys Ala Leu Gly Ala Ala Leu Ser Ala Arg Gly Pro 
                85                  90                  95      
Val Tyr Thr Glu Gln Pro Gly Ala Pro Ala Pro Asp Leu Pro Leu Pro 
            100                 105                 110         
Asp Gly Leu Leu Gln Val Pro Phe Arg Asp Ala Trp Pro Gly Thr Phe 
        115                 120                 125             
Ser Phe Ile Ile Glu Thr Trp Arg Glu Glu Leu Gly Asp Gln Ile Gly 
    130                 135                 140                 
Gly Pro Ala Trp Ser Leu Leu Ala Arg Val Ala Gly Arg Arg Arg Leu 
145                 150                 155                 160 
Ala Ala Gly Gly Pro Trp Ala Arg Asp Ile Gln Arg Ala Gly Ala Trp 
                165                 170                 175     
Glu Leu Arg Phe Ser Tyr Arg Ala Arg Cys Glu Pro Pro Ala Val Gly 
            180                 185                 190         
Thr Ala Cys Thr Arg Leu Cys Arg Pro Arg Ser Ala Pro Ser Arg Cys 
        195                 200                 205             
Gly Pro Gly Leu Arg Pro Cys Ala Pro Leu Glu Asp Glu Cys Glu Ala 
    210                 215                 220                 
Pro Leu Val Cys Arg Ala Gly Cys Ser Pro Glu His Gly Phe Cys Glu 
225                 230                 235                 240 
Gln Pro Gly Glu Cys Arg Cys Leu Glu Gly Trp Thr Gly Pro Leu Cys 
                245                 250                 255     
Thr Val Pro Val Ser Thr Ser Ser Cys Leu Ser Pro Arg Gly Pro Ser 
            260                 265                 270         
Ser Ala Thr Thr Gly Cys Leu Val Pro Gly Pro Gly Pro Cys Asp Gly 
        275                 280                 285             
Asn Pro Cys Ala Asn Gly Gly Ser Cys Ser Glu Thr Pro Arg Ser Phe 
    290                 295                 300                 
Glu Cys Thr Cys Pro Arg Gly Phe Tyr Gly Leu Arg Cys Glu Val Ser 
305                 310                 315                 320 
Gly Val Thr Cys Ala Asp Gly Pro Cys Phe Asn Gly Gly Leu Cys Val 
                325                 330                 335     
Gly Gly Ala Asp Pro Asp Ser Ala Tyr Ile Cys His Cys Pro Pro Gly 
            340                 345                 350         
Phe Gln Gly Ser Asn Cys Glu Lys Arg Val Asp Arg Cys Ser Leu Gln 
        355                 360                 365             
Pro Cys Arg Asn Gly Gly Leu Cys Leu Asp Leu Gly His Ala Leu Arg 
    370                 375                 380                 
Cys Arg Cys Arg Ala Gly Phe Ala Gly Pro Arg Cys Glu His Asp Leu 
385                 390                 395                 400 
Asp Asp Cys Ala Gly Arg Ala Cys Ala Asn Gly Gly Thr Cys Val Glu 
                405                 410                 415     
Gly Gly Gly Ala His Arg Cys Ser Cys Ala Leu Gly Phe Gly Gly Arg 
            420                 425                 430         
Asp Cys Arg Glu Arg Ala Asp Pro Cys Ala Ala Arg Pro Cys Ala His 
        435                 440                 445             
Gly Gly Arg Cys Tyr Ala His Phe Ser Gly Leu Val Cys Ala Cys Ala 
    450                 455                 460                 
Pro Gly Tyr Met Gly Ala Arg Cys Glu Phe Pro Val His Pro Asp Gly 
465                 470                 475                 480 
Ala Ser Ala Leu Pro Ala Ala Pro Pro Gly Leu Arg Pro Gly Asp Pro 
                485                 490                 495     
Gln Arg Tyr Leu Leu Pro Pro Ala Leu Gly Leu Leu Val Ala Ala Gly 
            500                 505                 510         
Val Ala Gly Ala Ala Leu Leu Leu Val His Val Arg Arg Arg Gly His 
        515                 520                 525             
Ser Gln Asp Ala Gly Ser Arg Leu Leu Ala Gly Thr Pro Glu Pro Ser 
    530                 535                 540                 
Val His Ala Leu Pro Asp Ala Leu Asn Asn Leu Arg Thr Gln Glu Gly 
545                 550                 555                 560 
Ser Gly Asp Gly Pro Ser Ser Ser Val Asp Trp Asn Arg Pro Glu Asp 
                565                 570                 575     
Val Asp Pro Gln Gly Ile Tyr Val Ile Ser Ala Pro Ser Ile Tyr Ala 
            580                 585                 590         
Arg Glu Val Ala Thr Pro Leu Phe Pro Pro Leu His Thr Gly Arg Ala 
        595                 600                 605             
Gly Gln Arg Gln His Leu Leu Phe Pro Tyr Pro Ser Ser Ile Leu Ser 
    610                 615                 620                 
Val Lys 
625     

<210> 111
<211> 626
<212> PRT
<213> Artificial Sequence

<220> 
<223> FLAG-tagged cyno DLL3 full length

<400> 111
Met Val Ser Pro Arg Met Ser Arg Leu Leu Ser Gln Thr Val Ile Leu 
1               5                   10                  15      
Ala Leu Ile Phe Ile Pro Gln Ala Arg Pro Asp Tyr Lys Asp Asp Asp 
            20                  25                  30          
Asp Lys Ala Gly Val Phe Glu Leu Gln Ile His Ser Phe Gly Pro Gly 
        35                  40                  45              
Pro Gly Pro Gly Ala Pro Arg Ser Pro Cys Ser Ala Arg Gly Pro Cys 
    50                  55                  60                  
Arg Leu Phe Phe Arg Val Cys Leu Lys Pro Gly Leu Ser Glu Glu Ala 
65                  70                  75                  80  
Ala Glu Ser Pro Cys Ala Leu Gly Ala Ala Leu Ser Ala Arg Gly Pro 
                85                  90                  95      
Val Tyr Thr Glu Gln Pro Glu Ala Pro Ala Pro Asp Leu Pro Leu Pro 
            100                 105                 110         
Asn Gly Leu Leu Gln Val Pro Phe Arg Asp Ala Trp Pro Gly Thr Phe 
        115                 120                 125             
Ser Leu Ile Ile Glu Thr Trp Arg Glu Glu Leu Gly Asp Gln Ile Gly 
    130                 135                 140                 
Gly Pro Ala Trp Ser Leu Leu Ala Arg Val Thr Arg Arg Arg Arg Leu 
145                 150                 155                 160 
Ala Ala Gly Gly Pro Trp Ala Arg Asp Ile Gln Arg Ala Gly Ala Trp 
                165                 170                 175     
Glu Leu Arg Phe Ser Tyr Arg Ala Arg Cys Glu Leu Pro Ala Val Gly 
            180                 185                 190         
Thr Ala Cys Thr Arg Leu Cys Arg Pro Arg Ser Ala Pro Ser Arg Cys 
        195                 200                 205             
Gly Pro Gly Leu Arg Pro Cys Ala Pro Leu Glu Asp Glu Cys Glu Ala 
    210                 215                 220                 
Pro Pro Val Cys Arg Ala Gly Cys Ser Leu Glu His Gly Phe Cys Glu 
225                 230                 235                 240 
Gln Pro Gly Glu Cys Arg Cys Leu Glu Gly Trp Thr Gly Pro Leu Cys 
                245                 250                 255     
Met Val Pro Val Ser Thr Ser Ser Cys Leu Gly Leu Arg Gly Pro Ser 
            260                 265                 270         
Ser Thr Thr Thr Gly Cys Leu Val Pro Gly Pro Gly Pro Cys Asp Gly 
        275                 280                 285             
Asn Pro Cys Ala Asn Gly Gly Ser Cys Ser Glu Thr Pro Gly Ser Phe 
    290                 295                 300                 
Glu Cys Thr Cys Pro Arg Gly Phe Tyr Gly Leu Arg Cys Glu Val Ser 
305                 310                 315                 320 
Gly Val Thr Cys Ala Asp Gly Pro Cys Phe Asn Gly Gly Leu Cys Val 
                325                 330                 335     
Gly Gly Ala Asp Pro Asp Ser Ala Tyr Ile Cys His Cys Pro Pro Gly 
            340                 345                 350         
Phe Gln Gly Ser Asn Cys Glu Lys Arg Val Asp Arg Cys Ser Leu Gln 
        355                 360                 365             
Pro Cys Arg Asn Gly Gly Leu Cys Leu Asp Leu Gly His Ala Leu Arg 
    370                 375                 380                 
Cys Arg Cys Arg Ala Gly Phe Ala Gly Pro Arg Cys Glu His Asp Leu 
385                 390                 395                 400 
Asp Asp Cys Ala Gly Arg Ala Cys Ala Asn Gly Gly Thr Cys Val Glu 
                405                 410                 415     
Gly Gly Gly Ala His Arg Cys Ser Cys Ala Leu Gly Phe Gly Gly Arg 
            420                 425                 430         
Asn Cys Arg Glu Arg Ala Asp Pro Cys Ala Ala Arg Pro Cys Ala His 
        435                 440                 445             
Gly Gly Arg Cys Tyr Ala His Phe Ser Gly Leu Val Cys Ala Cys Ala 
    450                 455                 460                 
Pro Gly Tyr Met Gly Ala Arg Cys Glu Phe Pro Val His Pro Asp Gly 
465                 470                 475                 480 
Val Ser Ala Leu Pro Ala Ala Pro Pro Gly Leu Arg Pro Gly Asp Pro 
                485                 490                 495     
Gln Arg Tyr Leu Leu Pro Pro Ala Leu Gly Leu Leu Val Ala Ala Gly 
            500                 505                 510         
Val Ala Gly Ala Ala Leu Leu Leu Val His Val Arg Arg Arg Gly His 
        515                 520                 525             
Ala Gln Asp Ala Gly Ser Arg Leu Leu Ala Gly Thr Pro Glu Pro Ser 
    530                 535                 540                 
Val His Ala Leu Pro Asp Ala Leu Asn Asn Leu Arg Thr Gln Glu Gly 
545                 550                 555                 560 
Pro Gly Asp Val Pro Ser Ser Ser Val Asp Trp Asn Arg Pro Glu Asp 
                565                 570                 575     
Val Asp Ser Arg Gly Ile Tyr Val Ile Ser Ala Pro Ser Ile Tyr Ala 
            580                 585                 590         
Arg Glu Val Ala Met Pro Leu Phe Pro Pro Leu His Thr Gly Arg Ala 
        595                 600                 605             
Gly Gln Arg Gln Asn Leu Leu Phe Pro Phe Pro Ser Ser Ile Leu Ser 
    610                 615                 620                 
Val Lys 
625     

<210> 112
<211> 731
<212> PRT
<213> Artificial Sequence

<220> 
<223> FLAG-tagged human DLL1 full length

<400> 112
Met Gly Ser Arg Cys Ala Leu Ala Leu Ala Val Leu Ser Ala Leu Leu 
1               5                   10                  15      
Cys Asp Tyr Lys Asp Asp Asp Asp Lys Gln Val Trp Ser Ser Gly Val 
            20                  25                  30          
Phe Glu Leu Lys Leu Gln Glu Phe Val Asn Lys Lys Gly Leu Leu Gly 
        35                  40                  45              
Asn Arg Asn Cys Cys Arg Gly Gly Ala Gly Pro Pro Pro Cys Ala Cys 
    50                  55                  60                  
Arg Thr Phe Phe Arg Val Cys Leu Lys His Tyr Gln Ala Ser Val Ser 
65                  70                  75                  80  
Pro Glu Pro Pro Cys Thr Tyr Gly Ser Ala Val Thr Pro Val Leu Gly 
                85                  90                  95      
Val Asp Ser Phe Ser Leu Pro Asp Gly Gly Gly Ala Asp Ser Ala Phe 
            100                 105                 110         
Ser Asn Pro Ile Arg Phe Pro Phe Gly Phe Thr Trp Pro Gly Thr Phe 
        115                 120                 125             
Ser Leu Ile Ile Glu Ala Leu His Thr Asp Ser Pro Asp Asp Leu Ala 
    130                 135                 140                 
Thr Glu Asn Pro Glu Arg Leu Ile Ser Arg Leu Ala Thr Gln Arg His 
145                 150                 155                 160 
Leu Thr Val Gly Glu Glu Trp Ser Gln Asp Leu His Ser Ser Gly Arg 
                165                 170                 175     
Thr Asp Leu Lys Tyr Ser Tyr Arg Phe Val Cys Asp Glu His Tyr Tyr 
            180                 185                 190         
Gly Glu Gly Cys Ser Val Phe Cys Arg Pro Arg Asp Asp Ala Phe Gly 
        195                 200                 205             
His Phe Thr Cys Gly Glu Arg Gly Glu Lys Val Cys Asn Pro Gly Trp 
    210                 215                 220                 
Lys Gly Pro Tyr Cys Thr Glu Pro Ile Cys Leu Pro Gly Cys Asp Glu 
225                 230                 235                 240 
Gln His Gly Phe Cys Asp Lys Pro Gly Glu Cys Lys Cys Arg Val Gly 
                245                 250                 255     
Trp Gln Gly Arg Tyr Cys Asp Glu Cys Ile Arg Tyr Pro Gly Cys Leu 
            260                 265                 270         
His Gly Thr Cys Gln Gln Pro Trp Gln Cys Asn Cys Gln Glu Gly Trp 
        275                 280                 285             
Gly Gly Leu Phe Cys Asn Gln Asp Leu Asn Tyr Cys Thr His His Lys 
    290                 295                 300                 
Pro Cys Lys Asn Gly Ala Thr Cys Thr Asn Thr Gly Gln Gly Ser Tyr 
305                 310                 315                 320 
Thr Cys Ser Cys Arg Pro Gly Tyr Thr Gly Ala Thr Cys Glu Leu Gly 
                325                 330                 335     
Ile Asp Glu Cys Asp Pro Ser Pro Cys Lys Asn Gly Gly Ser Cys Thr 
            340                 345                 350         
Asp Leu Glu Asn Ser Tyr Ser Cys Thr Cys Pro Pro Gly Phe Tyr Gly 
        355                 360                 365             
Lys Ile Cys Glu Leu Ser Ala Met Thr Cys Ala Asp Gly Pro Cys Phe 
    370                 375                 380                 
Asn Gly Gly Arg Cys Ser Asp Ser Pro Asp Gly Gly Tyr Ser Cys Arg 
385                 390                 395                 400 
Cys Pro Val Gly Tyr Ser Gly Phe Asn Cys Glu Lys Lys Ile Asp Tyr 
                405                 410                 415     
Cys Ser Ser Ser Pro Cys Ser Asn Gly Ala Lys Cys Val Asp Leu Gly 
            420                 425                 430         
Asp Ala Tyr Leu Cys Arg Cys Gln Ala Gly Phe Ser Gly Arg His Cys 
        435                 440                 445             
Asp Asp Asn Val Asp Asp Cys Ala Ser Ser Pro Cys Ala Asn Gly Gly 
    450                 455                 460                 
Thr Cys Arg Asp Gly Val Asn Asp Phe Ser Cys Thr Cys Pro Pro Gly 
465                 470                 475                 480 
Tyr Thr Gly Arg Asn Cys Ser Ala Pro Val Ser Arg Cys Glu His Ala 
                485                 490                 495     
Pro Cys His Asn Gly Ala Thr Cys His Glu Arg Gly His Arg Tyr Val 
            500                 505                 510         
Cys Glu Cys Ala Arg Gly Tyr Gly Gly Pro Asn Cys Gln Phe Leu Leu 
        515                 520                 525             
Pro Glu Leu Pro Pro Gly Pro Ala Val Val Asp Leu Thr Glu Lys Leu 
    530                 535                 540                 
Glu Gly Gln Gly Gly Pro Phe Pro Trp Val Ala Val Cys Ala Gly Val 
545                 550                 555                 560 
Ile Leu Val Leu Met Leu Leu Leu Gly Cys Ala Ala Val Val Val Cys 
                565                 570                 575     
Val Arg Leu Arg Leu Gln Lys His Arg Pro Pro Ala Asp Pro Cys Arg 
            580                 585                 590         
Gly Glu Thr Glu Thr Met Asn Asn Leu Ala Asn Cys Gln Arg Glu Lys 
        595                 600                 605             
Asp Ile Ser Val Ser Ile Ile Gly Ala Thr Gln Ile Lys Asn Thr Asn 
    610                 615                 620                 
Lys Lys Ala Asp Phe His Gly Asp His Ser Ala Asp Lys Asn Gly Phe 
625                 630                 635                 640 
Lys Ala Arg Tyr Pro Ala Val Asp Tyr Asn Leu Val Gln Asp Leu Lys 
                645                 650                 655     
Gly Asp Asp Thr Ala Val Arg Asp Ala His Ser Lys Arg Asp Thr Lys 
            660                 665                 670         
Cys Gln Pro Gln Gly Ser Ser Gly Glu Glu Lys Gly Thr Pro Thr Thr 
        675                 680                 685             
Leu Arg Gly Gly Glu Ala Ser Glu Arg Lys Arg Pro Asp Ser Gly Cys 
    690                 695                 700                 
Ser Thr Ser Lys Asp Thr Lys Tyr Gln Ser Val Tyr Val Ile Ser Glu 
705                 710                 715                 720 
Glu Lys Asp Glu Cys Val Ile Ala Thr Glu Val 
                725                 730     

<210> 113
<211> 693
<212> PRT
<213> Artificial Sequence

<220> 
<223> FLAG-tagged human DLL4 full length

<400> 113
Met Ala Ala Ala Ser Arg Ser Ala Ser Gly Trp Ala Leu Leu Leu Leu 
1               5                   10                  15      
Val Ala Leu Trp Gln Gln Arg Ala Ala Gly Asp Tyr Lys Asp Asp Asp 
            20                  25                  30          
Asp Lys Ser Gly Val Phe Gln Leu Gln Leu Gln Glu Phe Ile Asn Glu 
        35                  40                  45              
Arg Gly Val Leu Ala Ser Gly Arg Pro Cys Glu Pro Gly Cys Arg Thr 
    50                  55                  60                  
Phe Phe Arg Val Cys Leu Lys His Phe Gln Ala Val Val Ser Pro Gly 
65                  70                  75                  80  
Pro Cys Thr Phe Gly Thr Val Ser Thr Pro Val Leu Gly Thr Asn Ser 
                85                  90                  95      
Phe Ala Val Arg Asp Asp Ser Ser Gly Gly Gly Arg Asn Pro Leu Gln 
            100                 105                 110         
Leu Pro Phe Asn Phe Thr Trp Pro Gly Thr Phe Ser Leu Ile Ile Glu 
        115                 120                 125             
Ala Trp His Ala Pro Gly Asp Asp Leu Arg Pro Glu Ala Leu Pro Pro 
    130                 135                 140                 
Asp Ala Leu Ile Ser Lys Ile Ala Ile Gln Gly Ser Leu Ala Val Gly 
145                 150                 155                 160 
Gln Asn Trp Leu Leu Asp Glu Gln Thr Ser Thr Leu Thr Arg Leu Arg 
                165                 170                 175     
Tyr Ser Tyr Arg Val Ile Cys Ser Asp Asn Tyr Tyr Gly Asp Asn Cys 
            180                 185                 190         
Ser Arg Leu Cys Lys Lys Arg Asn Asp His Phe Gly His Tyr Val Cys 
        195                 200                 205             
Gln Pro Asp Gly Asn Leu Ser Cys Leu Pro Gly Trp Thr Gly Glu Tyr 
    210                 215                 220                 
Cys Gln Gln Pro Ile Cys Leu Ser Gly Cys His Glu Gln Asn Gly Tyr 
225                 230                 235                 240 
Cys Ser Lys Pro Ala Glu Cys Leu Cys Arg Pro Gly Trp Gln Gly Arg 
                245                 250                 255     
Leu Cys Asn Glu Cys Ile Pro His Asn Gly Cys Arg His Gly Thr Cys 
            260                 265                 270         
Ser Thr Pro Trp Gln Cys Thr Cys Asp Glu Gly Trp Gly Gly Leu Phe 
        275                 280                 285             
Cys Asp Gln Asp Leu Asn Tyr Cys Thr His His Ser Pro Cys Lys Asn 
    290                 295                 300                 
Gly Ala Thr Cys Ser Asn Ser Gly Gln Arg Ser Tyr Thr Cys Thr Cys 
305                 310                 315                 320 
Arg Pro Gly Tyr Thr Gly Val Asp Cys Glu Leu Glu Leu Ser Glu Cys 
                325                 330                 335     
Asp Ser Asn Pro Cys Arg Asn Gly Gly Ser Cys Lys Asp Gln Glu Asp 
            340                 345                 350         
Gly Tyr His Cys Leu Cys Pro Pro Gly Tyr Tyr Gly Leu His Cys Glu 
        355                 360                 365             
His Ser Thr Leu Ser Cys Ala Asp Ser Pro Cys Phe Asn Gly Gly Ser 
    370                 375                 380                 
Cys Arg Glu Arg Asn Gln Gly Ala Asn Tyr Ala Cys Glu Cys Pro Pro 
385                 390                 395                 400 
Asn Phe Thr Gly Ser Asn Cys Glu Lys Lys Val Asp Arg Cys Thr Ser 
                405                 410                 415     
Asn Pro Cys Ala Asn Gly Gly Gln Cys Leu Asn Arg Gly Pro Ser Arg 
            420                 425                 430         
Met Cys Arg Cys Arg Pro Gly Phe Thr Gly Thr Tyr Cys Glu Leu His 
        435                 440                 445             
Val Ser Asp Cys Ala Arg Asn Pro Cys Ala His Gly Gly Thr Cys His 
    450                 455                 460                 
Asp Leu Glu Asn Gly Leu Met Cys Thr Cys Pro Ala Gly Phe Ser Gly 
465                 470                 475                 480 
Arg Arg Cys Glu Val Arg Thr Ser Ile Asp Ala Cys Ala Ser Ser Pro 
                485                 490                 495     
Cys Phe Asn Arg Ala Thr Cys Tyr Thr Asp Leu Ser Thr Asp Thr Phe 
            500                 505                 510         
Val Cys Asn Cys Pro Tyr Gly Phe Val Gly Ser Arg Cys Glu Phe Pro 
        515                 520                 525             
Val Gly Leu Pro Pro Ser Phe Pro Trp Val Ala Val Ser Leu Gly Val 
    530                 535                 540                 
Gly Leu Ala Val Leu Leu Val Leu Leu Gly Met Val Ala Val Ala Val 
545                 550                 555                 560 
Arg Gln Leu Arg Leu Arg Arg Pro Asp Asp Gly Ser Arg Glu Ala Met 
                565                 570                 575     
Asn Asn Leu Ser Asp Phe Gln Lys Asp Asn Leu Ile Pro Ala Ala Gln 
            580                 585                 590         
Leu Lys Asn Thr Asn Gln Lys Lys Glu Leu Glu Val Asp Cys Gly Leu 
        595                 600                 605             
Asp Lys Ser Asn Cys Gly Lys Gln Gln Asn His Thr Leu Asp Tyr Asn 
    610                 615                 620                 
Leu Ala Pro Gly Pro Leu Gly Arg Gly Thr Met Pro Gly Lys Phe Pro 
625                 630                 635                 640 
His Ser Asp Lys Ser Leu Gly Glu Lys Ala Pro Leu Arg Leu His Ser 
                645                 650                 655     
Glu Lys Pro Glu Cys Arg Ile Ser Ala Ile Cys Ser Pro Arg Asp Ser 
            660                 665                 670         
Met Tyr Gln Ser Val Cys Leu Ile Ser Glu Glu Arg Asn Glu Cys Val 
        675                 680                 685             
Ile Ala Thr Glu Val 
    690             

<210> 114
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> FLAG tag

<400> 114
Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               

<210> 115
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Vk leader

<400> 115
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Asp 
            20      

<210> 116
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> 6His-myc tag

<400> 116
His His His His His His Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10                  15      



<210> 117
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ser/Gly linker

<400> 117
Ser Gly Gly Gly Gly Ser 
1               5       

<210> 118
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> EpCAM transmembrane domain

<400> 118
Ala Gly Val Ile Ala Val Ile Val Val Val Val Ile Ala Val Val Ala 
1               5                   10                  15      
Gly Ile Val Val Leu Val Ile 
            20              

<210> 119
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> EpCAM intracellular domain

<400> 119
Ser Arg Lys Lys Arg Met Ala Lys Tyr Glu Lys Ala Glu Ile Lys Glu 
1               5                   10                  15      
Met Gly Glu Met His Arg Glu Leu Asn Ala 
            20                  25      

<210> 120
<211> 34
<212> PRT
<213> Artificial Sequence

<220> 
<223> EGF1

<400> 120
Ala Pro Leu Val Cys Arg Ala Gly Cys Ser Pro Glu His Gly Phe Cys 
1               5                   10                  15      
Glu Gln Pro Gly Glu Cys Arg Cys Leu Glu Gly Trp Thr Gly Pro Leu 
            20                  25                  30          
Cys Thr 
        

<210> 121
<211> 95
<212> PRT
<213> Artificial Sequence

<220> 
<223> Hu DLL3 EGF 1+2

<400> 121
Ala Pro Leu Val Cys Arg Ala Gly Cys Ser Pro Glu His Gly Phe Cys 
1               5                   10                  15      
Glu Gln Pro Gly Glu Cys Arg Cys Leu Glu Gly Trp Thr Gly Pro Leu 
            20                  25                  30          
Cys Thr Val Pro Val Ser Thr Ser Ser Cys Leu Ser Pro Arg Gly Pro 
        35                  40                  45              
Ser Ser Ala Thr Thr Gly Cys Leu Val Pro Gly Pro Gly Pro Cys Asp 
    50                  55                  60                  
Gly Asn Pro Cys Ala Asn Gly Gly Ser Cys Ser Glu Thr Pro Arg Ser 
65                  70                  75                  80  
Phe Glu Cys Thr Cys Pro Arg Gly Phe Tyr Gly Leu Arg Cys Glu 
                85                  90                  95  

<210> 122
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> EGF2

<400> 122
Gly Pro Gly Pro Cys Asp Gly Asn Pro Cys Ala Asn Gly Gly Ser Cys 
1               5                   10                  15      
Ser Glu Thr Pro Arg Ser Phe Glu Cys Thr Cys Pro Arg Gly Phe Tyr 
            20                  25                  30          
Gly Leu Arg Cys Glu 
        35          

<210> 123
<211> 78
<212> PRT
<213> Artificial Sequence

<220> 
<223> Hu DLL3 EGF 2+3

<400> 123
Gly Pro Gly Pro Cys Asp Gly Asn Pro Cys Ala Asn Gly Gly Ser Cys 
1               5                   10                  15      
Ser Glu Thr Pro Arg Ser Phe Glu Cys Thr Cys Pro Arg Gly Phe Tyr 
            20                  25                  30          
Gly Leu Arg Cys Glu Val Ser Gly Val Thr Cys Ala Asp Gly Pro Cys 
        35                  40                  45              
Phe Asn Gly Gly Leu Cys Val Gly Gly Ala Asp Pro Asp Ser Ala Tyr 
    50                  55                  60                  
Ile Cys His Cys Pro Pro Gly Phe Gln Gly Ser Asn Cys Glu 
65                  70                  75              

<210> 124
<211> 40
<212> PRT
<213> Artificial Sequence

<220> 
<223> EGF3

<400> 124
Ser Gly Val Thr Cys Ala Asp Gly Pro Cys Phe Asn Gly Gly Leu Cys 
1               5                   10                  15      
Val Gly Gly Ala Asp Pro Asp Ser Ala Tyr Ile Cys His Cys Pro Pro 
            20                  25                  30          
Gly Phe Gln Gly Ser Asn Cys Glu 
        35                  40  

<210> 125
<211> 78
<212> PRT
<213> Artificial Sequence

<220> 
<223> Hu DLL3 EGF 3+4

<400> 125
Ser Gly Val Thr Cys Ala Asp Gly Pro Cys Phe Asn Gly Gly Leu Cys 
1               5                   10                  15      
Val Gly Gly Ala Asp Pro Asp Ser Ala Tyr Ile Cys His Cys Pro Pro 
            20                  25                  30          
Gly Phe Gln Gly Ser Asn Cys Glu Lys Arg Val Asp Arg Cys Ser Leu 
        35                  40                  45              
Gln Pro Cys Arg Asn Gly Gly Leu Cys Leu Asp Leu Gly His Ala Leu 
    50                  55                  60                  
Arg Cys Arg Cys Arg Ala Gly Phe Ala Gly Pro Arg Cys Glu 
65                  70                  75              

<210> 126
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> EGF4

<400> 126
Arg Val Asp Arg Cys Ser Leu Gln Pro Cys Arg Asn Gly Gly Leu Cys 
1               5                   10                  15      
Leu Asp Leu Gly His Ala Leu Arg Cys Arg Cys Arg Ala Gly Phe Ala 
            20                  25                  30          
Gly Pro Arg Cys Glu 
        35          

<210> 127
<211> 75
<212> PRT
<213> Artificial Sequence

<220> 
<223> Hu DLL3 EGF 4+5

<400> 127
Arg Val Asp Arg Cys Ser Leu Gln Pro Cys Arg Asn Gly Gly Leu Cys 
1               5                   10                  15      
Leu Asp Leu Gly His Ala Leu Arg Cys Arg Cys Arg Ala Gly Phe Ala 
            20                  25                  30          
Gly Pro Arg Cys Glu His Asp Leu Asp Asp Cys Ala Gly Arg Ala Cys 
        35                  40                  45              
Ala Asn Gly Gly Thr Cys Val Glu Gly Gly Gly Ala His Arg Cys Ser 
    50                  55                  60                  
Cys Ala Leu Gly Phe Gly Gly Arg Asp Cys Arg 
65                  70                  75  

<210> 128
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> EGF5

<400> 128
Asp Leu Asp Asp Cys Ala Gly Arg Ala Cys Ala Asn Gly Gly Thr Cys 
1               5                   10                  15      
Val Glu Gly Gly Gly Ala His Arg Cys Ser Cys Ala Leu Gly Phe Gly 
            20                  25                  30          
Gly Arg Asp Cys Arg 
        35          

<210> 129
<211> 73
<212> PRT
<213> Artificial Sequence

<220> 
<223> Hu DLL3 EGF 5+6

<400> 129
Asp Asp Cys Ala Gly Arg Ala Cys Ala Asn Gly Gly Thr Cys Val Glu 
1               5                   10                  15      
Gly Gly Gly Ala His Arg Cys Ser Cys Ala Leu Gly Phe Gly Gly Arg 
            20                  25                  30          
Asp Cys Arg Glu Arg Ala Asp Pro Cys Ala Ala Arg Pro Cys Ala His 
        35                  40                  45              
Gly Gly Arg Cys Tyr Ala His Phe Ser Gly Leu Val Cys Ala Cys Ala 
    50                  55                  60                  
Pro Gly Tyr Met Gly Ala Arg Cys Glu 
65                  70              

<210> 130
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> EGF6

<400> 130
Arg Ala Asp Pro Cys Ala Ala Arg Pro Cys Ala His Gly Gly Arg Cys 
1               5                   10                  15      
Tyr Ala His Phe Ser Gly Leu Val Cys Ala Cys Ala Pro Gly Tyr Met 
            20                  25                  30          
Gly Ala Arg Cys Glu 
        35          

<210> 131
<211> 64
<212> PRT
<213> Artificial Sequence

<220> 
<223> Hu DLL3 EGF6-membrane proximal peptide

<400> 131
Arg Ala Asp Pro Cys Ala Ala Arg Pro Cys Ala His Gly Gly Arg Cys 
1               5                   10                  15      
Tyr Ala His Phe Ser Gly Leu Val Cys Ala Cys Ala Pro Gly Tyr Met 
            20                  25                  30          
Gly Ala Arg Cys Glu Phe Pro Val His Pro Asp Gly Ala Ser Ala Leu 
        35                  40                  45              
Pro Ala Ala Pro Pro Gly Leu Arg Pro Gly Asp Pro Gln Arg Tyr Leu 
    50                  55                  60                  



<210> 132
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Membrane proximal peptide

<400> 132
Phe Pro Val His Pro Asp Gly Ala Ser Ala Leu Pro Ala Ala Pro Pro 
1               5                   10                  15      
Gly Leu Arg Pro Gly Asp Pro Gln Arg Tyr Leu 
            20                  25          

<210> 133
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#7 LCCDR1

<400> 133
Arg Ala Ser Gln Ser Val Asn Ser Asn Phe Leu Ala 
1               5                   10          

<210> 134
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#7 LCCDR2

<400> 134
Gly Thr Ser Ser Arg Ala Thr 
1               5           

<210> 135
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#7 LCCDR3

<400> 135
Gln Gln Tyr Gly Ser Ser Pro Trp Thr 
1               5                   

<210> 136
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#7 HCCDR1

<400> 136
Gly Phe Thr Phe Ser Ser Tyr Gly Met Phe 
1               5                   10  

<210> 137
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#7 HCCDR2

<400> 137
Val Ile Trp Leu Asp Gly Asp Asp Glu Asp Tyr Val Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 138
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#7 HCCDR3

<400> 138
Val Leu Asp Tyr 
1               

<210> 139
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#8 LCCDR1

<400> 139
Lys Ser Ser Gln Ser Val Leu Asp Thr Ser Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      
Val 
    

<210> 140
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#8 LCCDR2

<400> 140
Trp Ala Ser Thr Arg Glu Ser 
1               5           

<210> 141
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#8 LCCDR3

<400> 141
Gln His Tyr Tyr Asn Ser Pro Tyr Thr 
1               5                   

<210> 142
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#8 HCCDR1

<400> 142
Gly Tyr Thr Phe Thr Asp Tyr Tyr Met His 
1               5                   10  

<210> 143
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#8 HCCDR2

<400> 143
Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Glu Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 144
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#8 HCCDR3

<400> 144
Asp Ala Val Val Ile Pro Met Asp Tyr 
1               5                   

<210> 145
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#9 LCCDR1

<400> 145
Arg Ala Ser Gln Ser Ile Ser Arg Ser Tyr Leu Ala 
1               5                   10          

<210> 146
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#9 LCCDR2

<400> 146
Gly Ala Ser Ser Arg Ala Thr 
1               5           

<210> 147
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#9 LCCDR3

<400> 147
Gln Gln Tyr Gly Thr Ser Pro Ile Thr 
1               5                   

<210> 148
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#9 HCCDR1

<400> 148
Gly Gly Ser Ile Ser Ser Tyr Tyr Trp Ser 
1               5                   10  

<210> 149
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#9 HCCDR2

<400> 149
Tyr Arg Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      



<210> 150
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#9 HCCDR3

<400> 150
Ile Gly Val Ala Gly Phe Tyr Phe Asp Tyr 
1               5                   10  

<210> 151
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#10 LCCDR1

<400> 151
Arg Ala Ser Gln Ser Leu Asn Ser Ile Phe Leu Ala 
1               5                   10          

<210> 152
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#10 LCCDR2

<400> 152
Gly Ala Ser Ser Arg Ala Thr 
1               5           

<210> 153
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#10 LCCDR3

<400> 153
Gln Gln Tyr Gly Gly Ser Met Asn Thr 
1               5                   

<210> 154
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#10 HCCDR1

<400> 154
Gly Tyr Thr Phe Thr Gly Tyr Tyr Met His 
1               5                   10  

<210> 155
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#10 HCCDR2

<400> 155
Trp Ile Asn Pro Asn Ser Gly Gly Thr Ile Phe Ala Gln Arg Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 156
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#10 HCCDR3

<400> 156
Asp Phe Gly Asp Thr Val Gly Asn Ala Phe Asp Ile 
1               5                   10          

<210> 157
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#11 LCCDR1

<400> 157
Ser Ala Ser Ser Ser Val Thr Tyr Ile His 
1               5                   10  

<210> 158
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#11 LCCDR2

<400> 158
Arg Thr Ser Tyr Leu Ala Ser 
1               5           

<210> 159
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#11 LCCDR3

<400> 159
Gln Gln Arg Ser Ser Tyr Pro Arg Thr 
1               5                   

<210> 160
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#11 HCCDR1

<400> 160
Gly Tyr Ala Phe Ser Asp Tyr Trp Ile Thr 
1               5                   10  

<210> 161
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#11 HCCDR2

<400> 161
Asp Ile Tyr Pro Gly Ser Gly Ser Thr Lys Ser Ser Glu Lys Phe Lys 
1               5                   10                  15      
Asn 
    

<210> 162
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#11 HCCDR3

<400> 162
Leu Tyr Tyr Tyr Gly Ser His Tyr Leu Asp Thr 
1               5                   10      

<210> 163
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#12 LCCDR1

<400> 163
Ser Ala Ser Ser Ser Val Thr Tyr Ile His 
1               5                   10  

<210> 164
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#12 LCCDR2

<400> 164
Arg Thr Ser Tyr Leu Ala Ser 
1               5           

<210> 165
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#12 LCCDR3

<400> 165
Gln Gln Arg Ser Ser Tyr Pro Arg Thr 
1               5                   

<210> 166
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#12 HCCDR1

<400> 166
Gly Tyr Ala Phe Ser Asp Tyr Trp Ile Thr 
1               5                   10  

<210> 167
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#12 HCCDR2

<400> 167
Asp Ile Tyr Pro Gly Ser Gly Ser Thr Lys Ser Ser Glu Lys Phe Lys 
1               5                   10                  15      
Asn 
    

<210> 168
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#12 HCCDR3

<400> 168
Leu Tyr Tyr Tyr Gly Ser Tyr Tyr Leu Asp Thr 
1               5                   10      

<210> 169
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#13 LCCDR1

<400> 169
Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      



<210> 170
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#13 LCCDR2

<400> 170
Lys Val Ser Asn Arg Phe Ser 
1               5           

<210> 171
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#13 LCCDR3

<400> 171
Phe Gln Gly Ser His Val Pro Tyr Thr 
1               5                   

<210> 172
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#13 HCCDR1

<400> 172
Gly Tyr Thr Phe Thr Asn Tyr Gly Val Thr 
1               5                   10  

<210> 173
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#13 HCCDR2

<400> 173
Trp Ile Asn Thr Tyr Ser Gly Ala Pro Thr Tyr Ala Asp Asp Phe Asn 
1               5                   10                  15      
Gly 
    

<210> 174
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#13 HCCDR3

<400> 174
Leu Asp Asp Tyr Asp Leu Tyr Tyr Phe Asp Tyr 
1               5                   10      

<210> 175
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#14 LCCDR1

<400> 175
Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr Met Asn 
1               5                   10                  15  

<210> 176
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#14 LCCDR2

<400> 176
Ala Ala Ser Thr Leu Glu Ser 
1               5           

<210> 177
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#14 LCCDR3

<400> 177
Gln Gln Ser Asp Glu Asp Pro Trp Thr 
1               5                   

<210> 178
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#14 HCCDR1

<400> 178
Gly Tyr Thr Phe Thr Asp Tyr Tyr Ile His 
1               5                   10  

<210> 179
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#14 HCCDR2

<400> 179
Tyr Ile Tyr Pro Gly Asn Ser Tyr Thr Ala Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      
Asp 
    

<210> 180
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#14 HCCDR3

<400> 180
Ser Gly Gly Ser Ala Met Asp Tyr 
1               5               

<210> 181
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#15 LCCDR1

<400> 181
Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr Leu Asn 
1               5                   10                  15  

<210> 182
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#15 LCCDR2

<400> 182
Ala Ala Ser Asn Leu Glu Ser 
1               5           

<210> 183
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#15 LCCDR3

<400> 183
Gln Gln Ser Ser Glu Asp Pro Arg Thr 
1               5                   

<210> 184
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#15 HCCDR1

<400> 184
Gly Tyr Thr Phe Thr Asn Tyr Gly Met Asn 
1               5                   10  

<210> 185
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#15 HCCDR2

<400> 185
Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 186
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#15 HCCDR3

<400> 186
Phe His Phe Ser Ser Asn Gly Asp Ala Met Asp Asn 
1               5                   10          

<210> 187
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#16 LCCDR1

<400> 187
Arg Ala Ser Gln Ser Val Ser Asp Trp Leu Ala 
1               5                   10      

<210> 188
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#16 LCCDR2

<400> 188
Arg Ala Ser Ser Leu Glu Ser 
1               5           

<210> 189
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#16 LCCDR3

<400> 189
Gln Leu Tyr Asn Ser Tyr Ser Pro Thr 
1               5                   

<210> 190
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#16 HCCDR1

<400> 190
Gly Phe Thr Phe Ser Ser Tyr Trp Met Thr 
1               5                   10  

<210> 191
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#16 HCCDR2

<400> 191
Asn Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 192
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#16 HCCDR3

<400> 192
Asp Trp Gly Tyr Phe Asp Tyr 
1               5           

<210> 193
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#17 LCCDR1

<400> 193
Arg Ala Ser Glu Asn Ile Tyr Tyr Ser Leu Ala 
1               5                   10      

<210> 194
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#17 LCCDR2

<400> 194
Asn Thr Asn Ser Leu Glu Asp 
1               5           

<210> 195
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#17 LCCDR3

<400> 195
Lys Gln Ala Tyr Asp Phe Pro Leu Thr 
1               5                   

<210> 196
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#17 HCCDR1

<400> 196
Gly Tyr Thr Phe Ile Ser Tyr Tyr Ile His 
1               5                   10  

<210> 197
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#17 HCCDR2

<400> 197
Trp Ile Tyr Pro Gly Asp Gly Ser Thr Asn Asn Asn Glu Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 198
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#17 HCCDR3

<400> 198
Gly Glu Gly Asn Ala Met Asp Asp 
1               5               

<210> 199
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#18 LCCDR1

<400> 199
Arg Ala Ser Glu Asn Ile Tyr Tyr Ser Leu Ala 
1               5                   10      

<210> 200
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#18 LCCDR2

<400> 200
Asn Ala Asn Ser Leu Glu Asp 
1               5           

<210> 201
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#18 LCCDR3

<400> 201
Lys Gln Ala Tyr Asp Val Pro Leu Thr 
1               5                   

<210> 202
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#18 HCCDR1

<400> 202
Gly Tyr Thr Phe Thr Ala Tyr Phe Ile His 
1               5                   10  

<210> 203
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#18 HCCDR2

<400> 203
Tyr Ile Asp Pro Phe Asn Asp Asp Thr Asn Tyr Asn Val Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 204
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#18 HCCDR3

<400> 204
Gly Thr Ser Ala Thr Leu Asp Tyr 
1               5               

<210> 205
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#7 VL

<400> 205
Glu Ile Val Leu Thr Gln Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Ser Asn 
            20                  25                  30          
Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Thr Pro Arg Leu Leu 
        35                  40                  45              
Ile Phe Gly Thr Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Arg 
            100                 105             

<210> 206
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#7 VH

<400> 206
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Gly Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Trp Leu Asp Gly Asp Asp Glu Asp Tyr Val Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Val Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Val Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         
Ser 
    

<210> 207
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#8 VL

<400> 207
Asp Ile Val Met Ala Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Asp Thr 
            20                  25                  30          
Ser Asn Asn Lys Asn Tyr Leu Val Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln His 
                85                  90                  95      
Tyr Tyr Asn Ser Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         
Lys 
    

<210> 208
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#8 VH

<400> 208
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Glu Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Asp Ala Val Val Ile Pro Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210> 209
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#9 VL

<400> 209
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Arg Ser 
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Thr Ser Pro 
                85                  90                  95      
Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             

<210> 210
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#9 VH

<400> 210
Gln Val His Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Asp Trp Ile 
        35                  40                  45              
Gly Tyr Arg Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Leu Asp Met Ser Asn Asn Gln Phe Ser Leu 
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      
Ser Ile Gly Val Ala Gly Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210> 211
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#10 VL

<400> 211
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Leu Asn Ser Ile 
            20                  25                  30          
Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Trp Leu Leu 
        35                  40                  45              
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Gly Gly Ser Met 
                85                  90                  95      
Asn Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             

<210> 212
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#10 VH

<400> 212
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          
Tyr Met His Trp Val Arg Leu Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Ile Phe Ala Gln Arg Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Val Tyr 
65                  70                  75                  80  
Met Asp Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Phe Gly Asp Thr Val Gly Asn Ala Phe Asp Ile Trp Gly 
            100                 105                 110         
Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     

<210> 213
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#11 VL

<400> 213
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Thr Tyr Ile 
            20                  25                  30          
His Trp Phe Gln Gln Asn Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              
Arg Thr Ser Tyr Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Arg Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     

<210> 214
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#11 VH

<400> 214
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Gln Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Asp Tyr 
            20                  25                  30          
Trp Ile Thr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Asp Ile Tyr Pro Gly Ser Gly Ser Thr Lys Ser Ser Glu Lys Phe 
    50                  55                  60                  
Lys Asn Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Lys Ala Tyr 
65                  70                  75                  80  
Ile Gln Phe Ser Ser Leu Thr Pro Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Ser Leu Tyr Tyr Tyr Gly Ser His Tyr Leu Asp Thr Trp Gly Gln 
            100                 105                 110         
Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 

<210> 215
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#12 VL

<400> 215
Gln Val Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Thr Tyr Ile 
            20                  25                  30          
His Trp Phe Gln Gln Asn Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              
Arg Thr Ser Tyr Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Arg Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     

<210> 216
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#12 VH

<400> 216
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Phe Val Gln Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Asp Tyr 
            20                  25                  30          
Trp Ile Thr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Asp Ile Tyr Pro Gly Ser Gly Ser Thr Lys Ser Ser Glu Lys Phe 
    50                  55                  60                  
Lys Asn Arg Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Ile Gln Phe Ser Ser Leu Thr Pro Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Ser Leu Tyr Tyr Tyr Gly Ser Tyr Tyr Leu Asp Thr Trp Gly Gln 
            100                 105                 110         
Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 

<210> 217
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#13 VL

<400> 217
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ala Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Val Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         



<210> 218
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#13 VH

<400> 218
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Gly Val Thr Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              
Gly Trp Ile Asn Thr Tyr Ser Gly Ala Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  
Asn Gly Arg Phe Ala Leu Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      
Ala Arg Leu Asp Asp Tyr Asp Leu Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Ala Leu Thr Val Ser Ser 
        115                 120 

<210> 219
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#14 VL

<400> 219
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          
Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  
Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asp 
                85                  90                  95      
Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     

<210> 220
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#14 VH

<400> 220
Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Val 
1               5                   10                  15      
Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Ile 
            20                  25                  30          
His Trp Met Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr 
        35                  40                  45              
Ile Tyr Pro Gly Asn Ser Tyr Thr Ala Tyr Asn Gln Lys Phe Lys Asp 
    50                  55                  60                  
Lys Ala Thr Leu Thr Ala Asp Asn Pro Ser Ser Thr Ala Tyr Met Gln 
65                  70                  75                  80  
Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 
                85                  90                  95      
Ser Gly Gly Ser Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 221
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#15 VL

<400> 221
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          
Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  
Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Ser 
                85                  90                  95      
Glu Asp Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     

<210> 222
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#15 VH

<400> 222
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              
Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Met Ala Thr Tyr Phe Cys 
                85                  90                  95      
Thr Lys Phe His Phe Ser Ser Asn Gly Asp Ala Met Asp Asn Trp Gly 
            100                 105                 110         
Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     

<210> 223
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#16 VL

<400> 223
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Asp Trp 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 
        35                  40                  45              
Tyr Arg Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Ala Asp Phe Ala Thr Tyr Tyr Cys Gln Leu Tyr Asn Ser Tyr Ser Pro 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 224
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#16 VH

<400> 224
Glu Val His Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Asn Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Trp Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210> 225
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#17 VL

<400> 225
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ala Ala Ser Val Gly 
1               5                   10                  15      
Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Tyr Ser 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              
Tyr Asn Thr Asn Ser Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Gln Tyr Ser Met Lys Ile Asn Ser Met Gln Pro 
65                  70                  75                  80  
Glu Asp Thr Ala Thr Tyr Phe Cys Lys Gln Ala Tyr Asp Phe Pro Leu 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         

<210> 226
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#17 VH

<400> 226
Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr 
            20                  25                  30          
Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Asn Asn Asn Glu Lys Phe 
    50                  55                  60                  
Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      
Ala Arg Gly Glu Gly Asn Ala Met Asp Asp Trp Gly Gln Gly Thr Ser 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 227
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#18 VL

<400> 227
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ala Ala Ser Val Gly 
1               5                   10                  15      
Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Tyr Ser 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              
Tyr Asn Ala Asn Ser Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Gln Tyr Ser Met Lys Ile Asn Asn Met Gln Pro 
65                  70                  75                  80  
Glu Asp Thr Ala Thr Tyr Phe Cys Lys Gln Ala Tyr Asp Val Pro Leu 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         

<210> 228
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#18 VH

<400> 228
Gln Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Met Ser Cys Glu Ala Ser Gly Tyr Thr Phe Thr Ala Tyr 
            20                  25                  30          
Phe Ile His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Tyr Ile Asp Pro Phe Asn Asp Asp Thr Asn Tyr Asn Val Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ser Asp Thr Ser Ser Ser Ile Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ser Phe Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Thr Ser Ala Thr Leu Asp Tyr Trp Gly His Gly Thr Thr 
            100                 105                 110         
Leu Thr Val Ser Ser 
        115         

<210> 229
<211> 469
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#7 scFab

<400> 229
Glu Ile Val Leu Thr Gln Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Ser Asn 
            20                  25                  30          
Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Thr Pro Arg Leu Leu 
        35                  40                  45              
Ile Phe Gly Thr Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Arg Arg Thr Val Ala 
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu Gly Lys Ser 
    210                 215                 220                 
Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly 
225                 230                 235                 240 
Ser Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser Gln Val Gln 
                245                 250                 255     
Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg 
            260                 265                 270         
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met Phe 
        275                 280                 285             
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile 
    290                 295                 300                 
Trp Leu Asp Gly Asp Asp Glu Asp Tyr Val Asp Ser Val Lys Gly Arg 
305                 310                 315                 320 
Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met 
                325                 330                 335     
Asn Ser Leu Arg Val Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Val 
            340                 345                 350         
Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        355                 360                 365             
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    370                 375                 380                 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
385                 390                 395                 400 
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                405                 410                 415     
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            420                 425                 430         
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        435                 440                 445             
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    450                 455                 460                 
Glu Pro Lys Ser Cys 
465                 

<210> 230
<211> 479
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#8 scFab

<400> 230
Asp Ile Val Met Ala Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Asp Thr 
            20                  25                  30          
Ser Asn Asn Lys Asn Tyr Leu Val Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln His 
                85                  90                  95      
Tyr Tyr Asn Ser Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly 
    210                 215                 220                 
Ser Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu 
225                 230                 235                 240 
Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly 
                245                 250                 255     
Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
            260                 265                 270         
Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             
Asp Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
    290                 295                 300                 
Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Glu Gln 
305                 310                 315                 320 
Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr 
                325                 330                 335     
Ala Tyr Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr 
            340                 345                 350         
Tyr Cys Thr Arg Asp Ala Val Val Ile Pro Met Asp Tyr Trp Gly Gln 
        355                 360                 365             
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    370                 375                 380                 
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
385                 390                 395                 400 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                405                 410                 415     
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            420                 425                 430         
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        435                 440                 445             
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    450                 455                 460                 
Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
465                 470                 475                 

<210> 231
<211> 474
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#9 scFab

<400> 231
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Arg Ser 
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Thr Ser Pro 
                85                  90                  95      
Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu Gly Lys Ser 
    210                 215                 220                 
Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly 
225                 230                 235                 240 
Ser Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser Gln Val His 
                245                 250                 255     
Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser 
            260                 265                 270         
Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr Tyr Trp Ser 
        275                 280                 285             
Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Asp Trp Ile Gly Tyr Arg 
    290                 295                 300                 
Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val 
305                 310                 315                 320 
Thr Ile Ser Leu Asp Met Ser Asn Asn Gln Phe Ser Leu Lys Leu Ser 
                325                 330                 335     
Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys Ala Ser Ile Gly 
            340                 345                 350         
Val Ala Gly Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        355                 360                 365             
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    370                 375                 380                 
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
385                 390                 395                 400 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                405                 410                 415     
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            420                 425                 430         
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        435                 440                 445             
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    450                 455                 460                 
Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
465                 470                 

<210> 232
<211> 477
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#10 scFab

<400> 232
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Leu Asn Ser Ile 
            20                  25                  30          
Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Trp Leu Leu 
        35                  40                  45              
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Gly Gly Ser Met 
                85                  90                  95      
Asn Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu Gly Lys Ser 
    210                 215                 220                 
Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly 
225                 230                 235                 240 
Ser Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser Gln Val Gln 
                245                 250                 255     
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys 
            260                 265                 270         
Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr Tyr Met His 
        275                 280                 285             
Trp Val Arg Leu Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile 
    290                 295                 300                 
Asn Pro Asn Ser Gly Gly Thr Ile Phe Ala Gln Arg Phe Gln Gly Arg 
305                 310                 315                 320 
Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Val Tyr Met Asp Leu 
                325                 330                 335     
Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp 
            340                 345                 350         
Phe Gly Asp Thr Val Gly Asn Ala Phe Asp Ile Trp Gly Gln Gly Thr 
        355                 360                 365             
Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    370                 375                 380                 
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
385                 390                 395                 400 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                405                 410                 415     
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            420                 425                 430         
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        435                 440                 445             
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    450                 455                 460                 
Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
465                 470                 475         

<210> 233
<211> 474
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#11 scFab

<400> 233
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Thr Tyr Ile 
            20                  25                  30          
His Trp Phe Gln Gln Asn Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              
Arg Thr Ser Tyr Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Arg Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             
Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu Gly Lys Ser Ser Gly 
    210                 215                 220                 
Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly Ser Gly 
225                 230                 235                 240 
Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
                245                 250                 255     
Gln Pro Gly Ala Glu Leu Val Gln Pro Gly Ser Ser Val Lys Met Ser 
            260                 265                 270         
Cys Lys Ala Ser Gly Tyr Ala Phe Ser Asp Tyr Trp Ile Thr Trp Val 
        275                 280                 285             
Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Asp Ile Tyr Pro 
    290                 295                 300                 
Gly Ser Gly Ser Thr Lys Ser Ser Glu Lys Phe Lys Asn Lys Ala Thr 
305                 310                 315                 320 
Leu Thr Ala Asp Thr Ser Ser Ser Lys Ala Tyr Ile Gln Phe Ser Ser 
                325                 330                 335     
Leu Thr Pro Glu Asp Ser Ala Val Tyr Tyr Cys Val Ser Leu Tyr Tyr 
            340                 345                 350         
Tyr Gly Ser His Tyr Leu Asp Thr Trp Gly Gln Gly Thr Thr Leu Thr 
        355                 360                 365             
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    370                 375                 380                 
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
385                 390                 395                 400 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                405                 410                 415     
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            420                 425                 430         
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        435                 440                 445             
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    450                 455                 460                 
Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
465                 470                 

<210> 234
<211> 474
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#12 scFab

<400> 234
Gln Val Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Thr Tyr Ile 
            20                  25                  30          
His Trp Phe Gln Gln Asn Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              
Arg Thr Ser Tyr Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Arg Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             
Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu Gly Lys Ser Ser Gly 
    210                 215                 220                 
Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly Ser Gly 
225                 230                 235                 240 
Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
                245                 250                 255     
Gln Pro Gly Ala Glu Phe Val Gln Pro Gly Ser Ser Val Lys Met Ser 
            260                 265                 270         
Cys Lys Ala Ser Gly Tyr Ala Phe Ser Asp Tyr Trp Ile Thr Trp Val 
        275                 280                 285             
Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Asp Ile Tyr Pro 
    290                 295                 300                 
Gly Ser Gly Ser Thr Lys Ser Ser Glu Lys Phe Lys Asn Arg Ala Thr 
305                 310                 315                 320 
Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr Ile Gln Phe Ser Ser 
                325                 330                 335     
Leu Thr Pro Glu Asp Ser Ala Val Tyr Tyr Cys Val Ser Leu Tyr Tyr 
            340                 345                 350         
Tyr Gly Ser Tyr Tyr Leu Asp Thr Trp Gly Gln Gly Thr Thr Leu Thr 
        355                 360                 365             
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    370                 375                 380                 
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
385                 390                 395                 400 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                405                 410                 415     
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            420                 425                 430         
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        435                 440                 445             
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    450                 455                 460                 
Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
465                 470                 

<210> 235
<211> 480
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#13 scFab

<400> 235
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ala Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Val Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser 
    210                 215                 220                 
Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly 
225                 230                 235                 240 
Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly 
                245                 250                 255     
Ser Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly 
            260                 265                 270         
Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn 
        275                 280                 285             
Tyr Gly Val Thr Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp 
    290                 295                 300                 
Met Gly Trp Ile Asn Thr Tyr Ser Gly Ala Pro Thr Tyr Ala Asp Asp 
305                 310                 315                 320 
Phe Asn Gly Arg Phe Ala Leu Ser Leu Glu Thr Ser Ala Ser Thr Ala 
                325                 330                 335     
Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe 
            340                 345                 350         
Cys Ala Arg Leu Asp Asp Tyr Asp Leu Tyr Tyr Phe Asp Tyr Trp Gly 
        355                 360                 365             
Gln Gly Thr Ala Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    370                 375                 380                 
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
385                 390                 395                 400 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                405                 410                 415     
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            420                 425                 430         
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        435                 440                 445             
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    450                 455                 460                 
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
465                 470                 475                 480 



<210> 236
<211> 474
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#14 scFab

<400> 236
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          
Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  
Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asp 
                85                  90                  95      
Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu 
    210                 215                 220                 
Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys 
225                 230                 235                 240 
Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser 
                245                 250                 255     
Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Val 
            260                 265                 270         
Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Ile 
        275                 280                 285             
His Trp Met Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr 
    290                 295                 300                 
Ile Tyr Pro Gly Asn Ser Tyr Thr Ala Tyr Asn Gln Lys Phe Lys Asp 
305                 310                 315                 320 
Lys Ala Thr Leu Thr Ala Asp Asn Pro Ser Ser Thr Ala Tyr Met Gln 
                325                 330                 335     
Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 
            340                 345                 350         
Ser Gly Gly Ser Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
        355                 360                 365             
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    370                 375                 380                 
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
385                 390                 395                 400 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                405                 410                 415     
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            420                 425                 430         
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        435                 440                 445             
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    450                 455                 460                 
Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
465                 470                 

<210> 237
<211> 480
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#15 scFab

<400> 237
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          
Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  
Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Ser 
                85                  90                  95      
Glu Asp Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu 
    210                 215                 220                 
Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys 
225                 230                 235                 240 
Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser 
                245                 250                 255     
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
            260                 265                 270         
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
        275                 280                 285             
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
    290                 295                 300                 
Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
305                 310                 315                 320 
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
                325                 330                 335     
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Met Ala Thr Tyr Phe Cys 
            340                 345                 350         
Thr Lys Phe His Phe Ser Ser Asn Gly Asp Ala Met Asp Asn Trp Gly 
        355                 360                 365             
Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    370                 375                 380                 
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
385                 390                 395                 400 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                405                 410                 415     
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            420                 425                 430         
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        435                 440                 445             
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    450                 455                 460                 
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
465                 470                 475                 480 



<210> 238
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#16 scFab

<400> 238
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Asp Trp 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 
        35                  40                  45              
Tyr Arg Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Ala Asp Phe Ala Thr Tyr Tyr Cys Gln Leu Tyr Asn Ser Tyr Ser Pro 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu Gly Lys Ser Ser 
    210                 215                 220                 
Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly Ser 
225                 230                 235                 240 
Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser Glu Val His Leu 
                245                 250                 255     
Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
            260                 265                 270         
Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Trp Met Thr Trp 
        275                 280                 285             
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Asn Ile Lys 
    290                 295                 300                 
Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe 
305                 310                 315                 320 
Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn 
                325                 330                 335     
Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Arg Asp Trp 
            340                 345                 350         
Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        355                 360                 365             
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    370                 375                 380                 
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
385                 390                 395                 400 
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                405                 410                 415     
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            420                 425                 430         
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        435                 440                 445             
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    450                 455                 460                 
Arg Val Glu Pro Lys Ser Cys 
465                 470     

<210> 239
<211> 472
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#17 scFab

<400> 239
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ala Ala Ser Val Gly 
1               5                   10                  15      
Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Tyr Ser 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              
Tyr Asn Thr Asn Ser Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Gln Tyr Ser Met Lys Ile Asn Ser Met Gln Pro 
65                  70                  75                  80  
Glu Asp Thr Ala Thr Tyr Phe Cys Lys Gln Ala Tyr Asp Phe Pro Leu 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu Gly Lys Ser Ser 
    210                 215                 220                 
Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly Ser 
225                 230                 235                 240 
Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser Gln Ile Gln Leu 
                245                 250                 255     
Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala Ser Val Lys Ile 
            260                 265                 270         
Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr Tyr Ile His Trp 
        275                 280                 285             
Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Trp Ile Tyr 
    290                 295                 300                 
Pro Gly Asp Gly Ser Thr Asn Asn Asn Glu Lys Phe Lys Gly Lys Thr 
305                 310                 315                 320 
Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Leu Leu Ser 
                325                 330                 335     
Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Gly Glu 
            340                 345                 350         
Gly Asn Ala Met Asp Asp Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
        355                 360                 365             
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
    370                 375                 380                 
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
385                 390                 395                 400 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
                405                 410                 415     
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
            420                 425                 430         
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
        435                 440                 445             
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
    450                 455                 460                 
Lys Arg Val Glu Pro Lys Ser Cys 
465                 470         

<210> 240
<211> 472
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#18 scFab

<400> 240
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ala Ala Ser Val Gly 
1               5                   10                  15      
Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Tyr Ser 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              
Tyr Asn Ala Asn Ser Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Gln Tyr Ser Met Lys Ile Asn Asn Met Gln Pro 
65                  70                  75                  80  
Glu Asp Thr Ala Thr Tyr Phe Cys Lys Gln Ala Tyr Asp Val Pro Leu 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu Gly Lys Ser Ser 
    210                 215                 220                 
Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly Ser 
225                 230                 235                 240 
Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser Gln Val Gln Leu 
                245                 250                 255     
Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Ala Ser Val Lys Met 
            260                 265                 270         
Ser Cys Glu Ala Ser Gly Tyr Thr Phe Thr Ala Tyr Phe Ile His Trp 
        275                 280                 285             
Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asp 
    290                 295                 300                 
Pro Phe Asn Asp Asp Thr Asn Tyr Asn Val Lys Phe Lys Gly Lys Ala 
305                 310                 315                 320 
Thr Leu Thr Ser Asp Thr Ser Ser Ser Ile Ala Tyr Met Glu Leu Ser 
                325                 330                 335     
Ser Leu Thr Ser Glu Asp Ser Ser Phe Tyr Tyr Cys Ala Arg Gly Thr 
            340                 345                 350         
Ser Ala Thr Leu Asp Tyr Trp Gly His Gly Thr Thr Leu Thr Val Ser 
        355                 360                 365             
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
    370                 375                 380                 
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
385                 390                 395                 400 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
                405                 410                 415     
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
            420                 425                 430         
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
        435                 440                 445             
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
    450                 455                 460                 
Lys Arg Val Glu Pro Lys Ser Cys 
465                 470         

<210> 241
<211> 695
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#7 chain

<400> 241
Glu Ile Val Leu Thr Gln Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Ser Asn 
            20                  25                  30          
Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Thr Pro Arg Leu Leu 
        35                  40                  45              
Ile Phe Gly Thr Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Arg Arg Thr Val Ala 
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu Gly Lys Ser 
    210                 215                 220                 
Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly 
225                 230                 235                 240 
Ser Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser Gln Val Gln 
                245                 250                 255     
Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg 
            260                 265                 270         
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met Phe 
        275                 280                 285             
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile 
    290                 295                 300                 
Trp Leu Asp Gly Asp Asp Glu Asp Tyr Val Asp Ser Val Lys Gly Arg 
305                 310                 315                 320 
Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met 
                325                 330                 335     
Asn Ser Leu Arg Val Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Val 
            340                 345                 350         
Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        355                 360                 365             
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    370                 375                 380                 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
385                 390                 395                 400 
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                405                 410                 415     
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            420                 425                 430         
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        435                 440                 445             
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    450                 455                 460                 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
465                 470                 475                 480 
Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                485                 490                 495     
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            500                 505                 510         
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        515                 520                 525             
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    530                 535                 540                 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
545                 550                 555                 560 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                565                 570                 575     
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            580                 585                 590         
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
        595                 600                 605             
Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    610                 615                 620                 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
625                 630                 635                 640 
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                645                 650                 655     
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            660                 665                 670         
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        675                 680                 685             
Ser Leu Ser Leu Ser Pro Gly 
    690                 695 

<210> 242
<211> 705
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#8 chain

<400> 242
Asp Ile Val Met Ala Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Asp Thr 
            20                  25                  30          
Ser Asn Asn Lys Asn Tyr Leu Val Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln His 
                85                  90                  95      
Tyr Tyr Asn Ser Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly 
    210                 215                 220                 
Ser Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu 
225                 230                 235                 240 
Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly 
                245                 250                 255     
Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
            260                 265                 270         
Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        275                 280                 285             
Asp Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
    290                 295                 300                 
Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Glu Gln 
305                 310                 315                 320 
Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr 
                325                 330                 335     
Ala Tyr Met Glu Leu Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr 
            340                 345                 350         
Tyr Cys Thr Arg Asp Ala Val Val Ile Pro Met Asp Tyr Trp Gly Gln 
        355                 360                 365             
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    370                 375                 380                 
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
385                 390                 395                 400 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                405                 410                 415     
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            420                 425                 430         
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        435                 440                 445             
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    450                 455                 460                 
Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
465                 470                 475                 480 
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
                485                 490                 495     
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            500                 505                 510         
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        515                 520                 525             
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    530                 535                 540                 
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
545                 550                 555                 560 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                565                 570                 575     
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            580                 585                 590         
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        595                 600                 605             
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    610                 615                 620                 
Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
625                 630                 635                 640 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                645                 650                 655     
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            660                 665                 670         
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        675                 680                 685             
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    690                 695                 700                 
Gly 
705 

<210> 243
<211> 700
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#9 chain

<400> 243
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Arg Ser 
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Thr Ser Pro 
                85                  90                  95      
Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu Gly Lys Ser 
    210                 215                 220                 
Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly 
225                 230                 235                 240 
Ser Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser Gln Val His 
                245                 250                 255     
Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser 
            260                 265                 270         
Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr Tyr Trp Ser 
        275                 280                 285             
Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Asp Trp Ile Gly Tyr Arg 
    290                 295                 300                 
Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val 
305                 310                 315                 320 
Thr Ile Ser Leu Asp Met Ser Asn Asn Gln Phe Ser Leu Lys Leu Ser 
                325                 330                 335     
Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys Ala Ser Ile Gly 
            340                 345                 350         
Val Ala Gly Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        355                 360                 365             
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    370                 375                 380                 
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
385                 390                 395                 400 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                405                 410                 415     
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            420                 425                 430         
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        435                 440                 445             
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    450                 455                 460                 
Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
465                 470                 475                 480 
Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
                485                 490                 495     
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            500                 505                 510         
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        515                 520                 525             
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    530                 535                 540                 
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
545                 550                 555                 560 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                565                 570                 575     
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            580                 585                 590         
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        595                 600                 605             
Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys 
    610                 615                 620                 
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
625                 630                 635                 640 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                645                 650                 655     
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            660                 665                 670         
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        675                 680                 685             
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    690                 695                 700 

<210> 244
<211> 703
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#10 chain

<400> 244
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Leu Asn Ser Ile 
            20                  25                  30          
Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Trp Leu Leu 
        35                  40                  45              
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Gly Gly Ser Met 
                85                  90                  95      
Asn Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu Gly Lys Ser 
    210                 215                 220                 
Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly 
225                 230                 235                 240 
Ser Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser Gln Val Gln 
                245                 250                 255     
Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys 
            260                 265                 270         
Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr Tyr Met His 
        275                 280                 285             
Trp Val Arg Leu Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile 
    290                 295                 300                 
Asn Pro Asn Ser Gly Gly Thr Ile Phe Ala Gln Arg Phe Gln Gly Arg 
305                 310                 315                 320 
Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Val Tyr Met Asp Leu 
                325                 330                 335     
Asn Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp 
            340                 345                 350         
Phe Gly Asp Thr Val Gly Asn Ala Phe Asp Ile Trp Gly Gln Gly Thr 
        355                 360                 365             
Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    370                 375                 380                 
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
385                 390                 395                 400 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                405                 410                 415     
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            420                 425                 430         
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        435                 440                 445             
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    450                 455                 460                 
Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
465                 470                 475                 480 
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
                485                 490                 495     
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            500                 505                 510         
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        515                 520                 525             
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    530                 535                 540                 
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
545                 550                 555                 560 
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                565                 570                 575     
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            580                 585                 590         
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        595                 600                 605             
Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys 
    610                 615                 620                 
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
625                 630                 635                 640 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                645                 650                 655     
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            660                 665                 670         
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        675                 680                 685             
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    690                 695                 700             

<210> 245
<211> 700
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#11 chain

<400> 245
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Thr Tyr Ile 
            20                  25                  30          
His Trp Phe Gln Gln Asn Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              
Arg Thr Ser Tyr Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Arg Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             
Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu Gly Lys Ser Ser Gly 
    210                 215                 220                 
Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly Ser Gly 
225                 230                 235                 240 
Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
                245                 250                 255     
Gln Pro Gly Ala Glu Leu Val Gln Pro Gly Ser Ser Val Lys Met Ser 
            260                 265                 270         
Cys Lys Ala Ser Gly Tyr Ala Phe Ser Asp Tyr Trp Ile Thr Trp Val 
        275                 280                 285             
Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Asp Ile Tyr Pro 
    290                 295                 300                 
Gly Ser Gly Ser Thr Lys Ser Ser Glu Lys Phe Lys Asn Lys Ala Thr 
305                 310                 315                 320 
Leu Thr Ala Asp Thr Ser Ser Ser Lys Ala Tyr Ile Gln Phe Ser Ser 
                325                 330                 335     
Leu Thr Pro Glu Asp Ser Ala Val Tyr Tyr Cys Val Ser Leu Tyr Tyr 
            340                 345                 350         
Tyr Gly Ser His Tyr Leu Asp Thr Trp Gly Gln Gly Thr Thr Leu Thr 
        355                 360                 365             
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    370                 375                 380                 
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
385                 390                 395                 400 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                405                 410                 415     
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            420                 425                 430         
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        435                 440                 445             
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    450                 455                 460                 
Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
465                 470                 475                 480 
Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
                485                 490                 495     
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            500                 505                 510         
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        515                 520                 525             
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    530                 535                 540                 
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
545                 550                 555                 560 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                565                 570                 575     
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            580                 585                 590         
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        595                 600                 605             
Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys 
    610                 615                 620                 
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
625                 630                 635                 640 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                645                 650                 655     
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            660                 665                 670         
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        675                 680                 685             
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    690                 695                 700 

<210> 246
<211> 700
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#12 chain

<400> 246
Gln Val Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Thr Tyr Ile 
            20                  25                  30          
His Trp Phe Gln Gln Asn Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              
Arg Thr Ser Tyr Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Arg Thr 
                85                  90                  95      
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             
Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu Gly Lys Ser Ser Gly 
    210                 215                 220                 
Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly Ser Gly 
225                 230                 235                 240 
Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
                245                 250                 255     
Gln Pro Gly Ala Glu Phe Val Gln Pro Gly Ser Ser Val Lys Met Ser 
            260                 265                 270         
Cys Lys Ala Ser Gly Tyr Ala Phe Ser Asp Tyr Trp Ile Thr Trp Val 
        275                 280                 285             
Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Asp Ile Tyr Pro 
    290                 295                 300                 
Gly Ser Gly Ser Thr Lys Ser Ser Glu Lys Phe Lys Asn Arg Ala Thr 
305                 310                 315                 320 
Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr Ile Gln Phe Ser Ser 
                325                 330                 335     
Leu Thr Pro Glu Asp Ser Ala Val Tyr Tyr Cys Val Ser Leu Tyr Tyr 
            340                 345                 350         
Tyr Gly Ser Tyr Tyr Leu Asp Thr Trp Gly Gln Gly Thr Thr Leu Thr 
        355                 360                 365             
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    370                 375                 380                 
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
385                 390                 395                 400 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                405                 410                 415     
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            420                 425                 430         
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        435                 440                 445             
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    450                 455                 460                 
Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
465                 470                 475                 480 
Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
                485                 490                 495     
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            500                 505                 510         
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        515                 520                 525             
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    530                 535                 540                 
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
545                 550                 555                 560 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                565                 570                 575     
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            580                 585                 590         
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        595                 600                 605             
Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys 
    610                 615                 620                 
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
625                 630                 635                 640 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                645                 650                 655     
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            660                 665                 670         
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        675                 680                 685             
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    690                 695                 700 

<210> 247
<211> 706
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#13 chain

<400> 247
Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      
Asp Gln Ala Ala Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Lys Val Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser 
    210                 215                 220                 
Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly 
225                 230                 235                 240 
Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly 
                245                 250                 255     
Ser Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly 
            260                 265                 270         
Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn 
        275                 280                 285             
Tyr Gly Val Thr Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp 
    290                 295                 300                 
Met Gly Trp Ile Asn Thr Tyr Ser Gly Ala Pro Thr Tyr Ala Asp Asp 
305                 310                 315                 320 
Phe Asn Gly Arg Phe Ala Leu Ser Leu Glu Thr Ser Ala Ser Thr Ala 
                325                 330                 335     
Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe 
            340                 345                 350         
Cys Ala Arg Leu Asp Asp Tyr Asp Leu Tyr Tyr Phe Asp Tyr Trp Gly 
        355                 360                 365             
Gln Gly Thr Ala Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    370                 375                 380                 
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
385                 390                 395                 400 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                405                 410                 415     
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            420                 425                 430         
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        435                 440                 445             
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    450                 455                 460                 
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
465                 470                 475                 480 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
                485                 490                 495     
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            500                 505                 510         
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        515                 520                 525             
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    530                 535                 540                 
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
545                 550                 555                 560 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                565                 570                 575     
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            580                 585                 590         
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        595                 600                 605             
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    610                 615                 620                 
Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
625                 630                 635                 640 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                645                 650                 655     
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            660                 665                 670         
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        675                 680                 685             
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    690                 695                 700                 
Pro Gly 
705     

<210> 248
<211> 700
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#14 chain

<400> 248
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          
Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  
Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asp 
                85                  90                  95      
Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu 
    210                 215                 220                 
Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys 
225                 230                 235                 240 
Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser 
                245                 250                 255     
Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Val 
            260                 265                 270         
Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Ile 
        275                 280                 285             
His Trp Met Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr 
    290                 295                 300                 
Ile Tyr Pro Gly Asn Ser Tyr Thr Ala Tyr Asn Gln Lys Phe Lys Asp 
305                 310                 315                 320 
Lys Ala Thr Leu Thr Ala Asp Asn Pro Ser Ser Thr Ala Tyr Met Gln 
                325                 330                 335     
Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 
            340                 345                 350         
Ser Gly Gly Ser Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
        355                 360                 365             
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    370                 375                 380                 
Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
385                 390                 395                 400 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                405                 410                 415     
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            420                 425                 430         
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        435                 440                 445             
Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    450                 455                 460                 
Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
465                 470                 475                 480 
Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
                485                 490                 495     
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            500                 505                 510         
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        515                 520                 525             
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    530                 535                 540                 
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
545                 550                 555                 560 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                565                 570                 575     
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            580                 585                 590         
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        595                 600                 605             
Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys 
    610                 615                 620                 
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
625                 630                 635                 640 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                645                 650                 655     
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            660                 665                 670         
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        675                 680                 685             
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    690                 695                 700 

<210> 249
<211> 706
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#15 chain

<400> 249
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          
Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  
Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Ser 
                85                  90                  95      
Glu Asp Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu 
    210                 215                 220                 
Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys 
225                 230                 235                 240 
Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser 
                245                 250                 255     
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
            260                 265                 270         
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
        275                 280                 285             
Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
    290                 295                 300                 
Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
305                 310                 315                 320 
Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
                325                 330                 335     
Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Met Ala Thr Tyr Phe Cys 
            340                 345                 350         
Thr Lys Phe His Phe Ser Ser Asn Gly Asp Ala Met Asp Asn Trp Gly 
        355                 360                 365             
Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    370                 375                 380                 
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
385                 390                 395                 400 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                405                 410                 415     
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            420                 425                 430         
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        435                 440                 445             
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    450                 455                 460                 
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
465                 470                 475                 480 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
                485                 490                 495     
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            500                 505                 510         
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        515                 520                 525             
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    530                 535                 540                 
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
545                 550                 555                 560 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                565                 570                 575     
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            580                 585                 590         
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        595                 600                 605             
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    610                 615                 620                 
Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
625                 630                 635                 640 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                645                 650                 655     
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            660                 665                 670         
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        675                 680                 685             
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    690                 695                 700                 
Pro Gly 
705     

<210> 250
<211> 697
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#16 chain

<400> 250
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Asp Trp 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 
        35                  40                  45              
Tyr Arg Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Ala Asp Phe Ala Thr Tyr Tyr Cys Gln Leu Tyr Asn Ser Tyr Ser Pro 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu Gly Lys Ser Ser 
    210                 215                 220                 
Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly Ser 
225                 230                 235                 240 
Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser Glu Val His Leu 
                245                 250                 255     
Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
            260                 265                 270         
Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Trp Met Thr Trp 
        275                 280                 285             
Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Asn Ile Lys 
    290                 295                 300                 
Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe 
305                 310                 315                 320 
Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn 
                325                 330                 335     
Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Arg Asp Trp 
            340                 345                 350         
Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        355                 360                 365             
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    370                 375                 380                 
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
385                 390                 395                 400 
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                405                 410                 415     
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            420                 425                 430         
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        435                 440                 445             
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    450                 455                 460                 
Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
465                 470                 475                 480 
Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                485                 490                 495     
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            500                 505                 510         
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        515                 520                 525             
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    530                 535                 540                 
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
545                 550                 555                 560 
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                565                 570                 575     
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            580                 585                 590         
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        595                 600                 605             
Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr 
    610                 615                 620                 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
625                 630                 635                 640 
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                645                 650                 655     
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            660                 665                 670         
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        675                 680                 685             
Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    690                 695         

<210> 251
<211> 698
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#17 chain

<400> 251
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ala Ala Ser Val Gly 
1               5                   10                  15      
Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Tyr Ser 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              
Tyr Asn Thr Asn Ser Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Gln Tyr Ser Met Lys Ile Asn Ser Met Gln Pro 
65                  70                  75                  80  
Glu Asp Thr Ala Thr Tyr Phe Cys Lys Gln Ala Tyr Asp Phe Pro Leu 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu Gly Lys Ser Ser 
    210                 215                 220                 
Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly Ser 
225                 230                 235                 240 
Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser Gln Ile Gln Leu 
                245                 250                 255     
Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala Ser Val Lys Ile 
            260                 265                 270         
Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ser Tyr Tyr Ile His Trp 
        275                 280                 285             
Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Trp Ile Tyr 
    290                 295                 300                 
Pro Gly Asp Gly Ser Thr Asn Asn Asn Glu Lys Phe Lys Gly Lys Thr 
305                 310                 315                 320 
Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Leu Leu Ser 
                325                 330                 335     
Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Gly Glu 
            340                 345                 350         
Gly Asn Ala Met Asp Asp Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
        355                 360                 365             
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
    370                 375                 380                 
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
385                 390                 395                 400 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
                405                 410                 415     
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
            420                 425                 430         
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
        435                 440                 445             
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
    450                 455                 460                 
Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
465                 470                 475                 480 
Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
                485                 490                 495     
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            500                 505                 510         
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        515                 520                 525             
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    530                 535                 540                 
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
545                 550                 555                 560 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                565                 570                 575     
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            580                 585                 590         
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
        595                 600                 605             
Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 
    610                 615                 620                 
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
625                 630                 635                 640 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                645                 650                 655     
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            660                 665                 670         
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        675                 680                 685             
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    690                 695             

<210> 252
<211> 698
<212> PRT
<213> Artificial Sequence

<220> 
<223> DLL3#18 chain

<400> 252
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ala Ala Ser Val Gly 
1               5                   10                  15      
Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Tyr Ser 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              
Tyr Asn Ala Asn Ser Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Gln Tyr Ser Met Lys Ile Asn Asn Met Gln Pro 
65                  70                  75                  80  
Glu Asp Thr Ala Thr Tyr Phe Cys Lys Gln Ala Tyr Asp Val Pro Leu 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Glu Gly Lys Ser Ser 
    210                 215                 220                 
Gly Ser Gly Ser Glu Ser Lys Ser Thr Glu Gly Lys Ser Ser Gly Ser 
225                 230                 235                 240 
Gly Ser Glu Ser Lys Ser Thr Gly Gly Gly Gly Ser Gln Val Gln Leu 
                245                 250                 255     
Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Ala Ser Val Lys Met 
            260                 265                 270         
Ser Cys Glu Ala Ser Gly Tyr Thr Phe Thr Ala Tyr Phe Ile His Trp 
        275                 280                 285             
Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asp 
    290                 295                 300                 
Pro Phe Asn Asp Asp Thr Asn Tyr Asn Val Lys Phe Lys Gly Lys Ala 
305                 310                 315                 320 
Thr Leu Thr Ser Asp Thr Ser Ser Ser Ile Ala Tyr Met Glu Leu Ser 
                325                 330                 335     
Ser Leu Thr Ser Glu Asp Ser Ser Phe Tyr Tyr Cys Ala Arg Gly Thr 
            340                 345                 350         
Ser Ala Thr Leu Asp Tyr Trp Gly His Gly Thr Thr Leu Thr Val Ser 
        355                 360                 365             
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
    370                 375                 380                 
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
385                 390                 395                 400 
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
                405                 410                 415     
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
            420                 425                 430         
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
        435                 440                 445             
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
    450                 455                 460                 
Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
465                 470                 475                 480 
Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
                485                 490                 495     
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            500                 505                 510         
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        515                 520                 525             
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    530                 535                 540                 
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
545                 550                 555                 560 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                565                 570                 575     
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            580                 585                 590         
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
        595                 600                 605             
Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 
    610                 615                 620                 
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
625                 630                 635                 640 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                645                 650                 655     
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            660                 665                 670         
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        675                 680                 685             
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    690                 695             

<210> 253
<211> 61
<212> PRT
<213> Artificial Sequence

<220> 
<223> region of heavy chain

<400> 253
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
1               5                   10                  15      
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            20                  25                  30          
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        35                  40                  45              
Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    50                  55                  60      

<210> 254
<211> 330
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mouse

<400> 254
Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly 
1               5                   10                  15      
Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
    50                  55                  60                  
Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile 
65                  70                  75                  80  
Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      
Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys 
            100                 105                 110         
Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
        115                 120                 125             
Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys 
    130                 135                 140                 
Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp 
145                 150                 155                 160 
Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg 
                165                 170                 175     
Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln 
            180                 185                 190         
His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn 
        195                 200                 205             
Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly 
    210                 215                 220                 
Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu 
225                 230                 235                 240 
Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met 
                245                 250                 255     
Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu 
            260                 265                 270         
Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe 
        275                 280                 285             
Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn 
    290                 295                 300                 
Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr 
305                 310                 315                 320 
Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
                325                 330 

<210> 255
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mouse

<400> 255
Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      
Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
            20                  25                  30          
Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
        35                  40                  45              
Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  
Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
65                  70                  75                  80  
Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
                85                  90                  95      
Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
            100                 105         

<210> 256
<211> 446
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD1-1 HC

<400> 256
Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Ala Ser 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Tyr Ile Ser Gly Gly Gly Gly Asp Thr Tyr Tyr Ser Ser Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg His Ser Asn Val Asn Tyr Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             
Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 
Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         
Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         
Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     
Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     

<210> 257
<211> 218
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD1-1 LC

<400> 257
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Met Ser Cys Arg Ala Ser Glu Asn Ile Asp Thr Ser 
            20                  25                  30          
Gly Ile Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Val Ala Ser Asn Gln Gly Ser Gly Ile Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  
Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      
Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             

<210> 258
<211> 446
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD1-2 HC

<400> 258
Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Ala Ser 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Tyr Ile Ser Gly Gly Gly Gly Asp Thr Tyr Tyr Ser Ser Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg His Ser Asn Pro Asn Tyr Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             
Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 
Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         
Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         
Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     
Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     

<210> 259
<211> 218
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD1-2 LC

<400> 259
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Met Ser Cys Arg Ala Ser Glu Asn Ile Asp Thr Ser 
            20                  25                  30          
Gly Ile Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Val Ala Ser Asn Gln Gly Ser Gly Ile Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  
Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      
Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             

<210> 260
<211> 446
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD1-3 HC

<400> 260
Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Lys Ser 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Tyr Ile Ser Gly Gly Gly Gly Asp Thr Tyr Tyr Ser Ser Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg His Ser Asn Val Asn Tyr Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             
Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 
Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         
Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         
Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     
Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     

<210> 261
<211> 218
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD1-3 LC

<400> 261
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Met Ser Cys Arg Ala Ser Glu Asn Ile Asp Val Ser 
            20                  25                  30          
Gly Ile Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Val Ala Ser Asn Gln Gly Ser Gly Ile Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  
Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      
Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             

<210> 262
<211> 446
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD1-4 HC

<400> 262
Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Lys Ser 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Tyr Ile Ser Gly Gly Gly Gly Asp Thr Tyr Tyr Ser Ser Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg His Ser Asn Val Asn Tyr Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             
Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 
Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         
Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         
Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     
Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     

<210> 263
<211> 218
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD1-4 LC

<400> 263
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Met Ser Cys Arg Ala Ser Glu Asn Ile Asp Val Ser 
            20                  25                  30          
Gly Ile Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Val Ala Ser Asn Gln Gly Ser Gly Ile Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  
Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      
Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             

<210> 264
<211> 446
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD1-5 HC

<400> 264
Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Lys Ser 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Tyr Ile Ser Gly Gly Gly Gly Asp Thr Tyr Tyr Ser Ser Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg His Ser Asn Val Asn Tyr Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             
Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 
Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         
Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         
Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     
Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445     

<210> 265
<211> 218
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD1-5 LC

<400> 265
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Met Ser Cys Arg Ala Ser Glu Asn Ile Asp Val Ser 
            20                  25                  30          
Gly Ile Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Val Ala Ser Asn Gln Gly Ser Gly Ile Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  
Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      
Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             

