                         SEQUENCE LISTING

<110>  The Secretary of State for Health
 
<120>  METHODS FOR DETECTING ANTIVIRAL-DRUG RESISTANT VIRUS

<130>  P51053GB

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  1131
<212>  DNA
<213>  Herpes simplex virus 1

<400>  1
atggcttcgt acccctgcca tcaacacgcg tctgcgttcg accaggctgc gcgttctcgc       60

ggccataaca accgacgtac ggcgttgcgc cctcgccggc agcaaaaagc cacggaagtc      120

cgcctggagc agaaaatgcc cacgctactg cgggtttata tagacggtcc ccacgggatg      180

gggaaaacca ccaccacgca actgctggtg gccctgggtt cgcgcgacga tatcgtctac      240

gtacccgagc cgatgactta ctggcgggtg ttgggggctt ccgagacaat cgcgaacatc      300

tacaccacac aacaccgcct cgaccagggt gagatatcgg ccggggacgc ggcggtggta      360

atgacaagcg cccagataac aatgggcatg ccttatgccg tgaccgacgc cgttctggct      420

cctcatatcg ggggggaggc tgggagctca catgccccgc ccccggccct caccctcatc      480

ttcgaccgcc atcccatcgc cgccctcctg tgctacccgg ccgcgcgata ccttatgggc      540

agcatgaccc cccaggccgt gctggcgttc gtggccctca tcccgccgac cttgcccggc      600

acaaacatcg tgttgggggc ccttccggag gacagacaca tcgaccgcct ggccaaacgc      660

cagcgccccg gcgagcggct tgacctggct atgctggccg cgattcgccg cgtttatggg      720

ctgcttgcca atacggtgcg gtatctgcag ggcggcgggt cgtggcggga ggattgggga      780

cagctttcgg gggcggccgt gccgccccag ggtgccgagc cccagagcaa cgcgggccca      840

cgaccccata tcggggacac gttatttacc ctgtttcggg cccccgagtt gctggccccc      900

aacggcgacc tgtataacgt gtttgcctgg gctttggacg tcttggccaa acgcctccgt      960

cccatgcacg tctttatcct ggattacgac caatcgcccg ccggctgccg ggacgccctg     1020

ctgcaactta cctccgggat ggtccagacc cacgtcacca ccccaggctc cataccgacg     1080

atctgcgacc tggcgcgcac gtttgcccgg gagatggggg aggctaactg a              1131


<210>  2
<211>  376
<212>  PRT
<213>  Herpes simplex virus 1

<400>  2

Met Ala Ser Tyr Pro Cys His Gln His Ala Ser Ala Phe Asp Gln Ala 
1               5                   10                  15      


Ala Arg Ser Arg Gly His Asn Asn Arg Arg Thr Ala Leu Arg Pro Arg 
            20                  25                  30          


Arg Gln Gln Lys Ala Thr Glu Val Arg Leu Glu Gln Lys Met Pro Thr 
        35                  40                  45              


Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr 
    50                  55                  60                  


Thr Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr 
65                  70                  75                  80  


Val Pro Glu Pro Met Thr Tyr Trp Arg Val Leu Gly Ala Ser Glu Thr 
                85                  90                  95      


Ile Ala Asn Ile Tyr Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile 
            100                 105                 110         


Ser Ala Gly Asp Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr Met 
        115                 120                 125             


Gly Met Pro Tyr Ala Val Thr Asp Ala Val Leu Ala Pro His Ile Gly 
    130                 135                 140                 


Gly Glu Ala Gly Ser Ser His Ala Pro Pro Pro Ala Leu Thr Leu Ile 
145                 150                 155                 160 


Phe Asp Arg His Pro Ile Ala Ala Leu Leu Cys Tyr Pro Ala Ala Arg 
                165                 170                 175     


Tyr Leu Met Gly Ser Met Thr Pro Gln Ala Val Leu Ala Phe Val Ala 
            180                 185                 190         


Leu Ile Pro Pro Thr Leu Pro Gly Thr Asn Ile Val Leu Gly Ala Leu 
        195                 200                 205             


Pro Glu Asp Arg His Ile Asp Arg Leu Ala Lys Arg Gln Arg Pro Gly 
    210                 215                 220                 


Glu Arg Leu Asp Leu Ala Met Leu Ala Ala Ile Arg Arg Val Tyr Gly 
225                 230                 235                 240 


Leu Leu Ala Asn Thr Val Arg Tyr Leu Gln Gly Gly Gly Ser Trp Arg 
                245                 250                 255     


Glu Asp Trp Gly Gln Leu Ser Gly Ala Ala Val Pro Pro Gln Gly Ala 
            260                 265                 270         


Glu Pro Gln Ser Asn Ala Gly Pro Arg Pro His Ile Gly Asp Thr Leu 
        275                 280                 285             


Phe Thr Leu Phe Arg Ala Pro Glu Leu Leu Ala Pro Asn Gly Asp Leu 
    290                 295                 300                 


Tyr Asn Val Phe Ala Trp Ala Leu Asp Val Leu Ala Lys Arg Leu Arg 
305                 310                 315                 320 


Pro Met His Val Phe Ile Leu Asp Tyr Asp Gln Ser Pro Ala Gly Cys 
                325                 330                 335     


Arg Asp Ala Leu Leu Gln Leu Thr Ser Gly Met Val Gln Thr His Val 
            340                 345                 350         


Thr Thr Pro Gly Ser Ile Pro Thr Ile Cys Asp Leu Ala Arg Thr Phe 
        355                 360                 365             


Ala Arg Glu Met Gly Glu Ala Asn 
    370                 375     


<210>  3
<211>  3747
<212>  DNA
<213>  Herpes simplex virus 1

<400>  3
atgttttccg gtggcggcgg cccgctgtcc cccggaggaa agtcggcggc cagggcggcg       60

tccgggtttt ttgcgcccgc cggccctcgc ggagccagcc ggggaccccc gccttgtttg      120

aggcaaaact tttacaaccc ctacctcgcc ccagtcggga cgcaacagaa gccgaccggg      180

ccaacccagc gccatacgta ctatagcgaa tgcgatgaat ttcgattcat cgccccgcgg      240

gtgctggacg aggatgcccc cccggagaag cgcgccgggg tgcacgacgg tcacctcaag      300

cgcgccccca aggtgtactg cgggggggac gagcgcgacg tcctccgcgt cgggtcgggc      360

ggcttctggc cgcggcgctc gcgcctgtgg ggcggcgtgg accacgcccc ggcggggttc      420

aaccccaccg tcaccgtctt tcacgtgtac gacatcctgg agaacgtgga gcacgcgtac      480

ggcatgcgcg cggcccagtt ccacgcgcgg tttatggacg ccatcacacc gacggggacc      540

gtcatcacgc tcctgggcct gactccggaa ggccaccggg tggccgttca cgtttacggc      600

acgcggcagt acttttacat gaacaaggag gaggtcgaca ggcacctaca atgccgcgcc      660

ccacgagatc tctgcgagcg catggccgcg gccctgcgcg agtccccggg cgcgtcgttc      720

cgcggcatct ccgcggacca cttcgaggcg gaggtggtgg agcgcaccga cgtgtactac      780

tacgagacgc gccccgctct gttttaccgc gtctacgtcc gaagcgggcg cgtgctgtcg      840

tacctgtgcg acaacttctg cccggccatc aagaagtacg agggtggggt cgacgccacc      900

acccggttca tcctggacaa ccccgggttc gtcaccttcg gctggtaccg tctcaaaccg      960

ggccggaaca acacgctagc ccagccgcgg gccccgatgg ccttcgggac atccagcgac     1020

gtcgagttta actgtacggc ggacaacctg gccatcgagg ggggcatgag cgacctaccg     1080

gcatacaagc tcatgtgctt cgatatcgaa tgcaaggcgg ggggggagga cgagctggcc     1140

tttccggtgg ccgggcaccc ggaggacctg gtcatccaga tatcctgtct gctctacgac     1200

ctgtccacca ccgccctgga gcacgtcctc ctgttttcgc tcggttcctg cgacctcccc     1260

gaatcccacc tgaacgagct ggcggccagg ggcctgccca cgcccgtggt tctggaattc     1320

gacagcgaat tcgagatgct gttggccttc atgacccttg tgaaacagta cggccccgag     1380

ttcgtgaccg ggtacaacat catcaacttc gactggccct tcttgctggc caagctgacg     1440

gacatttaca aggtccccct ggacgggtac ggccgcatga acggccgggg cgtgtttcgc     1500

gtgtgggaca taggccagag ccacttccag aagcgcagca agataaaggt gaacggcatg     1560

gtgaacatcg acatgtacgg gattataacc gacaagatca agctctcgag ctacaagctc     1620

aacgccgtgg ccgaagccgt cctgaaggac aagaagaagg acctgagcta tcgcgacatc     1680

cccgcctact acgccgccgg gcccgcgcaa cgcggggtga tcggcgagta ctgcatacag     1740

gattccctgc tggtgggcca gctgtttttt aagtttttgc cccatctgga gctctcggcc     1800

gtcgcgcgct tggcgggtat taacatcacc cgcaccatct acgacggcca gcagatccgc     1860

gtctttacgt gcctgctgcg cctggccgac cagaagggct ttattctgcc ggacacccag     1920

gggcgattta ggggcgccgg gggggaggcg cccaagcgtc cggccgcagc ccgggaggac     1980

gaggagcggc cagaggagga gggggaggac gaggacgaac gcgaggaggg cgggggcgag     2040

cgggagccgg agggcgcgcg ggagaccgcc ggcaggcacg tggggtacca gggggccagg     2100

gtccttgacc ccacttccgg gtttcacgtg aaccccgtgg tggtgttcga ctttgccagc     2160

ctgtacccca gcatcatcca ggcccacaac ctgtgcttca gcacgctctc cctgagggcc     2220

gacgcagtgg cgcacctgga ggcgggcaag gactacctgg agatcgaggt gggggggcga     2280

cggctgttct tcgtcaaggc tcacgtgcga gagagcctcc tcagcatcct cctgcgggac     2340

tggctcgcca tgcgaaagca gatccgctcg cggattcccc agagcagccc cgaggaggcc     2400

gtgctcctgg acaagcagca ggccgccatc aaggtcgtgt gtaactcggt gtacgggttc     2460

acgggagtgc agcacggact cctgccgtgc ctgcacgttg ccgcgacggt gacgaccatc     2520

ggccgcgaga tgctgctcgc gacccgcgag tacgtccacg cgcgctgggc ggccttcgaa     2580

cagctcctgg ccgatttccc ggaggcggcc gacatgcgcg cccccgggcc ctattccatg     2640

cgcatcatct acggggacac ggactccatc tttgtgctgt gccgcggcct cacggccgcc     2700

gggctgacgg ccgtgggcga caagatggcg agccacatct cgcgcgcgct gtttctgccc     2760

cccatcaaac tcgagtgcga aaagacgttc accaagctgc tgctgatcgc caagaaaaag     2820

tacatcggcg tcatctacgg gggtaagatg ctcatcaagg gcgtggatct ggtgcgcaaa     2880

aacaactgcg cgtttatcaa ccgcacctcc agggccctgg tcgacctgct gttttacgac     2940

gataccgtct ccggagcggc cgccgcgtta gccgagcgcc ccgcggagga gtggctggcg     3000

cgacccctgc ccgagggact gcaggcgttc ggggccgtcc tcgtagacgc ccatcggcgc     3060

atcaccgacc cggagaggga catccaggac tttgtcctca ccgccgaact gagcagacac     3120

ccgcgcgcgt acaccaacaa gcgcctggcc cacctgacgg tgtattacaa gctcatggcc     3180

cgccgcgcgc aggtcccgtc catcaaggac cggatcccgt acgtgatcgt ggcccagacc     3240

cgcgaggtag aggagacggt cgcgcggctg gccgccctcc gcgagctaga cgccgccgcc     3300

ccaggggacg agcccgcccc ccccgcggcc ctgccctccc cggccaagcg cccccgggag     3360

acgccgtcgc ctgccgaccc cccgggaggc gcgtccaagc cccgcaagct gctggtgtcc     3420

gagctggccg aggatcccgc atacgccatt gcccacggcg tcgccctgaa cacggactat     3480

tacttctccc acctgttggg ggcggcgtgc gtgacattca aggccctgtt tgggaataac     3540

gccaagatca ccgagagtct gttaaaaagg tttattcccg aagtgtggca ccccccggac     3600

gacgtggccg cgcggctccg gaccgcaggg ttcggggcgg tgggtgccgg cgctacggcg     3660

gaggaaactc gtcgaatgtt gcatagagcc tttgatactc tagcatgagc cccccgtcga     3720

agctgatgtc cctcatttta caataaa                                         3747


<210>  4
<211>  1235
<212>  PRT
<213>  Herpes simplex virus 1

<400>  4

Met Phe Ser Gly Gly Gly Gly Pro Leu Ser Pro Gly Gly Lys Ser Ala 
1               5                   10                  15      


Ala Arg Ala Ala Ser Gly Phe Phe Ala Pro Ala Gly Pro Arg Gly Ala 
            20                  25                  30          


Ser Arg Gly Pro Pro Pro Cys Leu Arg Gln Asn Phe Tyr Asn Pro Tyr 
        35                  40                  45              


Leu Ala Pro Val Gly Thr Gln Gln Lys Pro Thr Gly Pro Thr Gln Arg 
    50                  55                  60                  


His Thr Tyr Tyr Ser Glu Cys Asp Glu Phe Arg Phe Ile Ala Pro Arg 
65                  70                  75                  80  


Val Leu Asp Glu Asp Ala Pro Pro Glu Lys Arg Ala Gly Val His Asp 
                85                  90                  95      


Gly His Leu Lys Arg Ala Pro Lys Val Tyr Cys Gly Gly Asp Glu Arg 
            100                 105                 110         


Asp Val Leu Arg Val Gly Ser Gly Gly Phe Trp Pro Arg Arg Ser Arg 
        115                 120                 125             


Leu Trp Gly Gly Val Asp His Ala Pro Ala Gly Phe Asn Pro Thr Val 
    130                 135                 140                 


Thr Val Phe His Val Tyr Asp Ile Leu Glu Asn Val Glu His Ala Tyr 
145                 150                 155                 160 


Gly Met Arg Ala Ala Gln Phe His Ala Arg Phe Met Asp Ala Ile Thr 
                165                 170                 175     


Pro Thr Gly Thr Val Ile Thr Leu Leu Gly Leu Thr Pro Glu Gly His 
            180                 185                 190         


Arg Val Ala Val His Val Tyr Gly Thr Arg Gln Tyr Phe Tyr Met Asn 
        195                 200                 205             


Lys Glu Glu Val Asp Arg His Leu Gln Cys Arg Ala Pro Arg Asp Leu 
    210                 215                 220                 


Cys Glu Arg Met Ala Ala Ala Leu Arg Glu Ser Pro Gly Ala Ser Phe 
225                 230                 235                 240 


Arg Gly Ile Ser Ala Asp His Phe Glu Ala Glu Val Val Glu Arg Thr 
                245                 250                 255     


Asp Val Tyr Tyr Tyr Glu Thr Arg Pro Ala Leu Phe Tyr Arg Val Tyr 
            260                 265                 270         


Val Arg Ser Gly Arg Val Leu Ser Tyr Leu Cys Asp Asn Phe Cys Pro 
        275                 280                 285             


Ala Ile Lys Lys Tyr Glu Gly Gly Val Asp Ala Thr Thr Arg Phe Ile 
    290                 295                 300                 


Leu Asp Asn Pro Gly Phe Val Thr Phe Gly Trp Tyr Arg Leu Lys Pro 
305                 310                 315                 320 


Gly Arg Asn Asn Thr Leu Ala Gln Pro Arg Ala Pro Met Ala Phe Gly 
                325                 330                 335     


Thr Ser Ser Asp Val Glu Phe Asn Cys Thr Ala Asp Asn Leu Ala Ile 
            340                 345                 350         


Glu Gly Gly Met Ser Asp Leu Pro Ala Tyr Lys Leu Met Cys Phe Asp 
        355                 360                 365             


Ile Glu Cys Lys Ala Gly Gly Glu Asp Glu Leu Ala Phe Pro Val Ala 
    370                 375                 380                 


Gly His Pro Glu Asp Leu Val Ile Gln Ile Ser Cys Leu Leu Tyr Asp 
385                 390                 395                 400 


Leu Ser Thr Thr Ala Leu Glu His Val Leu Leu Phe Ser Leu Gly Ser 
                405                 410                 415     


Cys Asp Leu Pro Glu Ser His Leu Asn Glu Leu Ala Ala Arg Gly Leu 
            420                 425                 430         


Pro Thr Pro Val Val Leu Glu Phe Asp Ser Glu Phe Glu Met Leu Leu 
        435                 440                 445             


Ala Phe Met Thr Leu Val Lys Gln Tyr Gly Pro Glu Phe Val Thr Gly 
    450                 455                 460                 


Tyr Asn Ile Ile Asn Phe Asp Trp Pro Phe Leu Leu Ala Lys Leu Thr 
465                 470                 475                 480 


Asp Ile Tyr Lys Val Pro Leu Asp Gly Tyr Gly Arg Met Asn Gly Arg 
                485                 490                 495     


Gly Val Phe Arg Val Trp Asp Ile Gly Gln Ser His Phe Gln Lys Arg 
            500                 505                 510         


Ser Lys Ile Lys Val Asn Gly Met Val Asn Ile Asp Met Tyr Gly Ile 
        515                 520                 525             


Ile Thr Asp Lys Ile Lys Leu Ser Ser Tyr Lys Leu Asn Ala Val Ala 
    530                 535                 540                 


Glu Ala Val Leu Lys Asp Lys Lys Lys Asp Leu Ser Tyr Arg Asp Ile 
545                 550                 555                 560 


Pro Ala Tyr Tyr Ala Ala Gly Pro Ala Gln Arg Gly Val Ile Gly Glu 
                565                 570                 575     


Tyr Cys Ile Gln Asp Ser Leu Leu Val Gly Gln Leu Phe Phe Lys Phe 
            580                 585                 590         


Leu Pro His Leu Glu Leu Ser Ala Val Ala Arg Leu Ala Gly Ile Asn 
        595                 600                 605             


Ile Thr Arg Thr Ile Tyr Asp Gly Gln Gln Ile Arg Val Phe Thr Cys 
    610                 615                 620                 


Leu Leu Arg Leu Ala Asp Gln Lys Gly Phe Ile Leu Pro Asp Thr Gln 
625                 630                 635                 640 


Gly Arg Phe Arg Gly Ala Gly Gly Glu Ala Pro Lys Arg Pro Ala Ala 
                645                 650                 655     


Ala Arg Glu Asp Glu Glu Arg Pro Glu Glu Glu Gly Glu Asp Glu Asp 
            660                 665                 670         


Glu Arg Glu Glu Gly Gly Gly Glu Arg Glu Pro Glu Gly Ala Arg Glu 
        675                 680                 685             


Thr Ala Gly Arg His Val Gly Tyr Gln Gly Ala Arg Val Leu Asp Pro 
    690                 695                 700                 


Thr Ser Gly Phe His Val Asn Pro Val Val Val Phe Asp Phe Ala Ser 
705                 710                 715                 720 


Leu Tyr Pro Ser Ile Ile Gln Ala His Asn Leu Cys Phe Ser Thr Leu 
                725                 730                 735     


Ser Leu Arg Ala Asp Ala Val Ala His Leu Glu Ala Gly Lys Asp Tyr 
            740                 745                 750         


Leu Glu Ile Glu Val Gly Gly Arg Arg Leu Phe Phe Val Lys Ala His 
        755                 760                 765             


Val Arg Glu Ser Leu Leu Ser Ile Leu Leu Arg Asp Trp Leu Ala Met 
    770                 775                 780                 


Arg Lys Gln Ile Arg Ser Arg Ile Pro Gln Ser Ser Pro Glu Glu Ala 
785                 790                 795                 800 


Val Leu Leu Asp Lys Gln Gln Ala Ala Ile Lys Val Val Cys Asn Ser 
                805                 810                 815     


Val Tyr Gly Phe Thr Gly Val Gln His Gly Leu Leu Pro Cys Leu His 
            820                 825                 830         


Val Ala Ala Thr Val Thr Thr Ile Gly Arg Glu Met Leu Leu Ala Thr 
        835                 840                 845             


Arg Glu Tyr Val His Ala Arg Trp Ala Ala Phe Glu Gln Leu Leu Ala 
    850                 855                 860                 


Asp Phe Pro Glu Ala Ala Asp Met Arg Ala Pro Gly Pro Tyr Ser Met 
865                 870                 875                 880 


Arg Ile Ile Tyr Gly Asp Thr Asp Ser Ile Phe Val Leu Cys Arg Gly 
                885                 890                 895     


Leu Thr Ala Ala Gly Leu Thr Ala Val Gly Asp Lys Met Ala Ser His 
            900                 905                 910         


Ile Ser Arg Ala Leu Phe Leu Pro Pro Ile Lys Leu Glu Cys Glu Lys 
        915                 920                 925             


Thr Phe Thr Lys Leu Leu Leu Ile Ala Lys Lys Lys Tyr Ile Gly Val 
    930                 935                 940                 


Ile Tyr Gly Gly Lys Met Leu Ile Lys Gly Val Asp Leu Val Arg Lys 
945                 950                 955                 960 


Asn Asn Cys Ala Phe Ile Asn Arg Thr Ser Arg Ala Leu Val Asp Leu 
                965                 970                 975     


Leu Phe Tyr Asp Asp Thr Val Ser Gly Ala Ala Ala Ala Leu Ala Glu 
            980                 985                 990         


Arg Pro Ala Glu Glu Trp Leu Ala  Arg Pro Leu Pro Glu  Gly Leu Gln 
        995                 1000                 1005             


Ala Phe  Gly Ala Val Leu Val  Asp Ala His Arg Arg  Ile Thr Asp 
    1010                 1015                 1020             


Pro Glu  Arg Asp Ile Gln Asp  Phe Val Leu Thr Ala  Glu Leu Ser 
    1025                 1030                 1035             


Arg His  Pro Arg Ala Tyr Thr  Asn Lys Arg Leu Ala  His Leu Thr 
    1040                 1045                 1050             


Val Tyr  Tyr Lys Leu Met Ala  Arg Arg Ala Gln Val  Pro Ser Ile 
    1055                 1060                 1065             


Lys Asp  Arg Ile Pro Tyr Val  Ile Val Ala Gln Thr  Arg Glu Val 
    1070                 1075                 1080             


Glu Glu  Thr Val Ala Arg Leu  Ala Ala Leu Arg Glu  Leu Asp Ala 
    1085                 1090                 1095             


Ala Ala  Pro Gly Asp Glu Pro  Ala Pro Pro Ala Ala  Leu Pro Ser 
    1100                 1105                 1110             


Pro Ala  Lys Arg Pro Arg Glu  Thr Pro Ser Pro Ala  Asp Pro Pro 
    1115                 1120                 1125             


Gly Gly  Ala Ser Lys Pro Arg  Lys Leu Leu Val Ser  Glu Leu Ala 
    1130                 1135                 1140             


Glu Asp  Pro Ala Tyr Ala Ile  Ala His Gly Val Ala  Leu Asn Thr 
    1145                 1150                 1155             


Asp Tyr  Tyr Phe Ser His Leu  Leu Gly Ala Ala Cys  Val Thr Phe 
    1160                 1165                 1170             


Lys Ala  Leu Phe Gly Asn Asn  Ala Lys Ile Thr Glu  Ser Leu Leu 
    1175                 1180                 1185             


Lys Arg  Phe Ile Pro Glu Val  Trp His Pro Pro Asp  Asp Val Ala 
    1190                 1195                 1200             


Ala Arg  Leu Arg Thr Ala Gly  Phe Gly Ala Val Gly  Ala Gly Ala 
    1205                 1210                 1215             


Thr Ala  Glu Glu Thr Arg Arg  Met Leu His Arg Ala  Phe Asp Thr 
    1220                 1225                 1230             


Leu Ala  
    1235 


<210>  5
<211>  1131
<212>  DNA
<213>  Herpes simplex virus 2

<400>  5
atggcttctc acgccggcca acagcacgcg cctgcgttcg gtcaggctgc tcgtgcgagc       60

gggcctaccg acggccgcgc ggcgtcccgt cctagccatc gccagggggc ctccggagcc      120

cgcggggatc cggagctgcc cacgctgctg cgggtttata tagacggacc ccacggggtg      180

gggaagacca ccacctccgc gcagctgatg gaggccctgg ggccgcgcga caatatcgtc      240

tacgtccccg agccgatgac ttactggcag gtgctggggg cctccgagac cctgacgaac      300

atctacaaca cgcagcaccg tctggaccgc ggcgagatat cggccgggga ggcggcggtg      360

gtaatgacca gcgcccagat aacaatgagc acgccttatg cggcgacgga cgccgttttg      420

gctcctcata tcggggggga ggctgtgggc ccgcaagccc cgcccccggc cctcaccctt      480

gttttcgacc ggcaccctat cgcctccctg ctgtgctacc cggccgcgcg gtacctcatg      540

ggaagcatga ccccccaggc cgtgttggcg ttcgtggccc tcatgccccc gaccgcgccc      600

ggcacgaacc tggtcctggg tgtccttccg gaggccgaac acgccgaccg cctggccaga      660

cgccaacgcc cgggcgagcg gcttgacctg gccatgctgt ccgccattcg ccgtgtctac      720

gatctactcg ccaacacggt gcggtacctg cagcgcggcg ggaggtggcg ggaggactgg      780

ggccggctga cgggggtcgc cgcggcgacc ccgcgccccg accccgagga cggcgcgggg      840

tctctgcccc gcatcgagga cacgctgttt gccctgttcc gcgttcccga gctgctggcc      900

cccaacgggg acttgtacca catttttgcc tgggtcttgg acgtcttggc cgaccgcctc      960

cttccgatgc atctatttgt cctggattac gatcagtcgc ccgtcgggtg tcgagacgcc     1020

ctgttgcgcc tcaccgccgg gatgatccca acccgcgtca caaccgccgg gtccatcgcc     1080

gagatacgcg acctggcgcg cacgtttgcc cgcgaggtgg ggggagttta g              1131


<210>  6
<211>  376
<212>  PRT
<213>  Herpes simplex virus 2

<400>  6

Met Ala Ser His Ala Gly Gln Gln His Ala Pro Ala Phe Gly Gln Ala 
1               5                   10                  15      


Ala Arg Ala Ser Gly Pro Thr Asp Gly Arg Ala Ala Ser Arg Pro Ser 
            20                  25                  30          


His Arg Gln Gly Ala Ser Gly Ala Arg Gly Asp Pro Glu Leu Pro Thr 
        35                  40                  45              


Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Val Gly Lys Thr Thr 
    50                  55                  60                  


Thr Ser Ala Gln Leu Met Glu Ala Leu Gly Pro Arg Asp Asn Ile Val 
65                  70                  75                  80  


Tyr Val Pro Glu Pro Met Thr Tyr Trp Gln Val Leu Gly Ala Ser Glu 
                85                  90                  95      


Thr Leu Thr Asn Ile Tyr Asn Thr Gln His Arg Leu Asp Arg Gly Glu 
            100                 105                 110         


Ile Ser Ala Gly Glu Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr 
        115                 120                 125             


Met Ser Thr Pro Tyr Ala Ala Thr Asp Ala Val Leu Ala Pro His Ile 
    130                 135                 140                 


Gly Gly Glu Ala Val Gly Pro Gln Ala Pro Pro Pro Ala Leu Thr Leu 
145                 150                 155                 160 


Val Phe Asp Arg His Pro Ile Ala Ser Leu Leu Cys Tyr Pro Ala Ala 
                165                 170                 175     


Arg Tyr Leu Met Gly Ser Met Thr Pro Gln Ala Val Leu Ala Phe Val 
            180                 185                 190         


Ala Leu Met Pro Pro Thr Ala Pro Gly Thr Asn Leu Val Leu Gly Val 
        195                 200                 205             


Leu Pro Glu Ala Glu His Ala Asp Arg Leu Ala Arg Arg Gln Arg Pro 
    210                 215                 220                 


Gly Glu Arg Leu Asp Leu Ala Met Leu Ser Ala Ile Arg Arg Val Tyr 
225                 230                 235                 240 


Asp Leu Leu Ala Asn Thr Val Arg Tyr Leu Gln Arg Gly Gly Arg Trp 
                245                 250                 255     


Arg Glu Asp Trp Gly Arg Leu Thr Gly Val Ala Ala Ala Thr Pro Arg 
            260                 265                 270         


Pro Asp Pro Glu Asp Gly Ala Gly Ser Leu Pro Arg Ile Glu Asp Thr 
        275                 280                 285             


Leu Phe Ala Leu Phe Arg Val Pro Glu Leu Leu Ala Pro Asn Gly Asp 
    290                 295                 300                 


Leu Tyr His Ile Phe Ala Trp Val Leu Asp Val Leu Ala Asp Arg Leu 
305                 310                 315                 320 


Leu Pro Met His Leu Phe Val Leu Asp Tyr Asp Gln Ser Pro Val Gly 
                325                 330                 335     


Cys Arg Asp Ala Leu Leu Arg Leu Thr Ala Gly Met Ile Pro Thr Arg 
            340                 345                 350         


Val Thr Thr Ala Gly Ser Ile Ala Glu Ile Arg Asp Leu Ala Arg Thr 
        355                 360                 365             


Phe Ala Arg Glu Val Gly Gly Val 
    370                 375     


<210>  7
<211>  3762
<212>  DNA
<213>  Herpes simplex virus 2

<400>  7
atgttttgtg ccgcgggcgg cccggcttcc cccgggggga agccggcggc tcgggcggcg       60

tctgggtttt ttgcccccca caacccccgg ggagccaccc agacggcacc gccgccttgc      120

cgccggcaga acttctacaa cccccacctc gctcagaccg gaacgcagcc aaaggccctc      180

gggccggctc agcgccatac gtactacagc gagtgcgacg aatttcgatt tatcgccccg      240

cgttcgctgg acgaggacgc ccccgcggag cagcgcaccg gggtccacga cggccgcctc      300

cggcgcgccc ctaaggtgta ctgcgggggg gacgagcgcg acgtcctccg cgtgggcccg      360

gagggcttct ggccgcgtcg cttgcgcctg tggggcggtg cggaccatgc ccccgagggg      420

ttcgacccca ccgtcaccgt cttccacgtg tacgacatcc tggagcacgt ggaacacgcg      480

tacagcatgc gcgccgccca gctccacgag cgatttatgg acgccatcac gcccgccggg      540

accgtcatca cgcttctggg tctgaccccc gaaggccatc gcgtcgccgt tcacgtctac      600

ggcacgcggc agtactttta catgaacaag gcggaggtgg atcggcacct gcagtgccgt      660

gccccgcgcg atctctgcga gcgcctggcg gcggccctgc gcgagtcgcc gggggcgtcg      720

ttccgcggca tctccgcgga ccacttcgag gcggaggtgg tggagcgcgc cgacgtgtac      780

tattacgaaa cgcgcccgac cctgtactac cgcgtcttcg tgcgaagcgg gcgcgcgctg      840

gcctacctgt gcgacaactt ttgccccgcg atcaggaagt acgagggggg cgtcgacgcc      900

accacccggt ttatcctgga caacccgggg tttgtcacct tcggctggta ccgcctcaag      960

cccggccgcg ggaacgcgcc ggcccaaccg cgccccccga cggcgttcgg aacctcgagc     1020

gacgtcgagt ttaactgcac ggcggacaac ctggccgtcg agggggccat gtgtgacctg     1080

ccggcctaca agctcatgtg cttcgatatc gaatgcaagg ccggggggga ggacgagctg     1140

gcctttccgg tcgcggaacg cccggaagac ctcgtcatcc agatctcctg tctgctctac     1200

gacctgtcca ccaccgccct cgagcacatc ctcctgtttt cgctcggatc ctgcgacctc     1260

cccgagtccc acctcagcga tctcgcctcc aggggcctgc cggcccccgt cgtcctggag     1320

tttgacagcg aattcgagat gctgctggcc ttcatgacct tcgtcaagca gtacggcccc     1380

gagttcgtga ccgggtacaa catcatcaac ttcgactggc ccttcgtcct gaccaagctg     1440

acggagatct acaaggtccc gctcgacggg tacgggcgca tgaacggccg gggtgtgttc     1500

cgcgtgtggg acatcggcca gagccacttt cagaagcgca gcaagatcaa ggtgaacggg     1560

atggtgaaca tcgacatgta cggcatcatc accgacaagg tcaaactctc cagctacaag     1620

ctgaacgccg tcgccgaggc cgtcttgaag gacaagaaga aggatctgag ctaccgcgac     1680

atccccgcct actacgcctc cgggcccgcg cagcgcgggg tgatcggcga gtattgtgtg     1740

caggactcgc tgctggtcgg gcagctgttc ttcaagtttc tgccgcacct ggagctttcc     1800

gccgtcgcgc gcctggcggg catcaacatc acccgcacca tctacgacgg ccagcagatc     1860

cgcgtcttca cgtgcctcct gcgccttgcg ggccagaagg gcttcatcct gccggacacc     1920

caggggcggt ttcggggcct cgacaaggag gcgcccaagc gcccggccgt gcctcggggg     1980

gaaggggagc ggccggggga cgggaacggg gacgaggata aggacgacga cgaggacggg     2040

gacgaggacg gggacgagcg cgaggaggtc gcgcgcgaga ccgggggccg gcacgttggg     2100

taccaggggg cccgggtcct cgaccccacc tccgggtttc acgtcgaccc cgtggtggtg     2160

tttgactttg ccagcctgta ccccagcatc atccaggccc acaacctgtg cttcagtacg     2220

ctctccctgc ggcccgaggc cgtcgcgcac ctggaggcgg accgggacta cctggagatc     2280

gaggtggggg gccgacggct gttcttcgtg aaggcccacg tacgcgagag cctgctgagc     2340

atcctgctgc gcgactggct ggccatgcga aagcagatcc gctcgcggat cccccagagc     2400

acccccgagg aggccgtcct cctcgacaag caacaggccg ccatcaaggt ggtgtgcaac     2460

tcggtgtacg ggttcaccgg ggtgcagcac ggtcttctgc cctgcctgca cgtggccgcc     2520

accgtgacga ccatcggccg cgagatgctc ctcgcgacgc gcgcgtacgt gcacgcgcgc     2580

tgggcggagt tcgatcagct gctggccgac tttccggagg cggccggcat gcgcgccccc     2640

ggtccgtact ccatgcgcat catctacggg gacacggact ccattttcgt tttgtgccgc     2700

ggcctcacgg ccgcgggcct ggtggccatg ggcgacaaga tggcgagcca catctcgcgc     2760

gcgctgttcc tccccccgat caagctcgag tgcgaaaaaa cgttcaccaa gctgctgctc     2820

atcgccaaga aaaagtacat cggcgtcatc tgcgggggca agatgctcat caagggcgtg     2880

gatctggtgc gcaaaaacaa ctgcgcgttt atcaaccgca cctccagggc cctggtcgac     2940

ctgctgtttt acgacgatac cgtatccgga gcggccgccg cgttagccga gcgccccgca     3000

gaggagtggc tggcgcgacc cctgcccgag ggactgcagg cgttcggggc cgtcctcgta     3060

gacgcccatc ggcgcatcac cgacccggag agggacatcc aggactttgt cctcaccgcc     3120

gaactgagca gacacccgcg cgcgtacacc aacaagcgcc tggcccacct gacggtgtat     3180

tacaagctca tggcccgccg cgcgcaggtc ccgtccatca aggaccggat cccgtacgtg     3240

atcgtggccc agacccgcga ggtagaggag acggtcgcgc ggctggccgc cctccgcgag     3300

ctagacgccg ccgccccagg ggacgagccc gcccccccag cggccctgcc ctccccggcc     3360

aagcgccccc gggagacgcc gtcgcatgcc gaccccccgg gaggcgcgtc caagccccgc     3420

aagctgctgg tgtccgagct ggcggaggat cccgggtacg ccatcgcccg gggcgttccg     3480

ctcaacacgg actattactt ctcgcacctg ctgggggcgg cctgcgtgac gttcaaggcc     3540

ctgtttggaa ataacgccaa gatcaccgag agtctgttaa agaggtttat tcccgagacg     3600

tggcaccccc cggacgacgt ggccgcgcgg ctcagggccg cggggttcgg gccggcgggg     3660

gccggcgcta cggcggagga aactcgtcga atgttgcata gagcctttga tactctagca     3720

tgagcccccc gtcgaagctg atgtcccgca tcttgcaata aa                        3762


<210>  8
<211>  1240
<212>  PRT
<213>  Herpes simplex virus 2

<400>  8

Met Phe Cys Ala Ala Gly Gly Pro Ala Ser Pro Gly Gly Lys Pro Ala 
1               5                   10                  15      


Ala Arg Ala Ala Ser Gly Phe Phe Ala Pro His Asn Pro Arg Gly Ala 
            20                  25                  30          


Thr Gln Thr Ala Pro Pro Pro Cys Arg Arg Gln Asn Phe Tyr Asn Pro 
        35                  40                  45              


His Leu Ala Gln Thr Gly Thr Gln Pro Lys Ala Leu Gly Pro Ala Gln 
    50                  55                  60                  


Arg His Thr Tyr Tyr Ser Glu Cys Asp Glu Phe Arg Phe Ile Ala Pro 
65                  70                  75                  80  


Arg Ser Leu Asp Glu Asp Ala Pro Ala Glu Gln Arg Thr Gly Val His 
                85                  90                  95      


Asp Gly Arg Leu Arg Arg Ala Pro Lys Val Tyr Cys Gly Gly Asp Glu 
            100                 105                 110         


Arg Asp Val Leu Arg Val Gly Pro Glu Gly Phe Trp Pro Arg Arg Leu 
        115                 120                 125             


Arg Leu Trp Gly Gly Ala Asp His Ala Pro Glu Gly Phe Asp Pro Thr 
    130                 135                 140                 


Val Thr Val Phe His Val Tyr Asp Ile Leu Glu His Val Glu His Ala 
145                 150                 155                 160 


Tyr Ser Met Arg Ala Ala Gln Leu His Glu Arg Phe Met Asp Ala Ile 
                165                 170                 175     


Thr Pro Ala Gly Thr Val Ile Thr Leu Leu Gly Leu Thr Pro Glu Gly 
            180                 185                 190         


His Arg Val Ala Val His Val Tyr Gly Thr Arg Gln Tyr Phe Tyr Met 
        195                 200                 205             


Asn Lys Ala Glu Val Asp Arg His Leu Gln Cys Arg Ala Pro Arg Asp 
    210                 215                 220                 


Leu Cys Glu Arg Leu Ala Ala Ala Leu Arg Glu Ser Pro Gly Ala Ser 
225                 230                 235                 240 


Phe Arg Gly Ile Ser Ala Asp His Phe Glu Ala Glu Val Val Glu Arg 
                245                 250                 255     


Ala Asp Val Tyr Tyr Tyr Glu Thr Arg Pro Thr Leu Tyr Tyr Arg Val 
            260                 265                 270         


Phe Val Arg Ser Gly Arg Ala Leu Ala Tyr Leu Cys Asp Asn Phe Cys 
        275                 280                 285             


Pro Ala Ile Arg Lys Tyr Glu Gly Gly Val Asp Ala Thr Thr Arg Phe 
    290                 295                 300                 


Ile Leu Asp Asn Pro Gly Phe Val Thr Phe Gly Trp Tyr Arg Leu Lys 
305                 310                 315                 320 


Pro Gly Arg Gly Asn Ala Pro Ala Gln Pro Arg Pro Pro Thr Ala Phe 
                325                 330                 335     


Gly Thr Ser Ser Asp Val Glu Phe Asn Cys Thr Ala Asp Asn Leu Ala 
            340                 345                 350         


Val Glu Gly Ala Met Cys Asp Leu Pro Ala Tyr Lys Leu Met Cys Phe 
        355                 360                 365             


Asp Ile Glu Cys Lys Ala Gly Gly Glu Asp Glu Leu Ala Phe Pro Val 
    370                 375                 380                 


Ala Glu Arg Pro Glu Asp Leu Val Ile Gln Ile Ser Cys Leu Leu Tyr 
385                 390                 395                 400 


Asp Leu Ser Thr Thr Ala Leu Glu His Ile Leu Leu Phe Ser Leu Gly 
                405                 410                 415     


Ser Cys Asp Leu Pro Glu Ser His Leu Ser Asp Leu Ala Ser Arg Gly 
            420                 425                 430         


Leu Pro Ala Pro Val Val Leu Glu Phe Asp Ser Glu Phe Glu Met Leu 
        435                 440                 445             


Leu Ala Phe Met Thr Phe Val Lys Gln Tyr Gly Pro Glu Phe Val Thr 
    450                 455                 460                 


Gly Tyr Asn Ile Ile Asn Phe Asp Trp Pro Phe Val Leu Thr Lys Leu 
465                 470                 475                 480 


Thr Glu Ile Tyr Lys Val Pro Leu Asp Gly Tyr Gly Arg Met Asn Gly 
                485                 490                 495     


Arg Gly Val Phe Arg Val Trp Asp Ile Gly Gln Ser His Phe Gln Lys 
            500                 505                 510         


Arg Ser Lys Ile Lys Val Asn Gly Met Val Asn Ile Asp Met Tyr Gly 
        515                 520                 525             


Ile Ile Thr Asp Lys Val Lys Leu Ser Ser Tyr Lys Leu Asn Ala Val 
    530                 535                 540                 


Ala Glu Ala Val Leu Lys Asp Lys Lys Lys Asp Leu Ser Tyr Arg Asp 
545                 550                 555                 560 


Ile Pro Ala Tyr Tyr Ala Ser Gly Pro Ala Gln Arg Gly Val Ile Gly 
                565                 570                 575     


Glu Tyr Cys Val Gln Asp Ser Leu Leu Val Gly Gln Leu Phe Phe Lys 
            580                 585                 590         


Phe Leu Pro His Leu Glu Leu Ser Ala Val Ala Arg Leu Ala Gly Ile 
        595                 600                 605             


Asn Ile Thr Arg Thr Ile Tyr Asp Gly Gln Gln Ile Arg Val Phe Thr 
    610                 615                 620                 


Cys Leu Leu Arg Leu Ala Gly Gln Lys Gly Phe Ile Leu Pro Asp Thr 
625                 630                 635                 640 


Gln Gly Arg Phe Arg Gly Leu Asp Lys Glu Ala Pro Lys Arg Pro Ala 
                645                 650                 655     


Val Pro Arg Gly Glu Gly Glu Arg Pro Gly Asp Gly Asn Gly Asp Glu 
            660                 665                 670         


Asp Lys Asp Asp Asp Glu Asp Gly Asp Glu Asp Gly Asp Glu Arg Glu 
        675                 680                 685             


Glu Val Ala Arg Glu Thr Gly Gly Arg His Val Gly Tyr Gln Gly Ala 
    690                 695                 700                 


Arg Val Leu Asp Pro Thr Ser Gly Phe His Val Asp Pro Val Val Val 
705                 710                 715                 720 


Phe Asp Phe Ala Ser Leu Tyr Pro Ser Ile Ile Gln Ala His Asn Leu 
                725                 730                 735     


Cys Phe Ser Thr Leu Ser Leu Arg Pro Glu Ala Val Ala His Leu Glu 
            740                 745                 750         


Ala Asp Arg Asp Tyr Leu Glu Ile Glu Val Gly Gly Arg Arg Leu Phe 
        755                 760                 765             


Phe Val Lys Ala His Val Arg Glu Ser Leu Leu Ser Ile Leu Leu Arg 
    770                 775                 780                 


Asp Trp Leu Ala Met Arg Lys Gln Ile Arg Ser Arg Ile Pro Gln Ser 
785                 790                 795                 800 


Thr Pro Glu Glu Ala Val Leu Leu Asp Lys Gln Gln Ala Ala Ile Lys 
                805                 810                 815     


Val Val Cys Asn Ser Val Tyr Gly Phe Thr Gly Val Gln His Gly Leu 
            820                 825                 830         


Leu Pro Cys Leu His Val Ala Ala Thr Val Thr Thr Ile Gly Arg Glu 
        835                 840                 845             


Met Leu Leu Ala Thr Arg Ala Tyr Val His Ala Arg Trp Ala Glu Phe 
    850                 855                 860                 


Asp Gln Leu Leu Ala Asp Phe Pro Glu Ala Ala Gly Met Arg Ala Pro 
865                 870                 875                 880 


Gly Pro Tyr Ser Met Arg Ile Ile Tyr Gly Asp Thr Asp Ser Ile Phe 
                885                 890                 895     


Val Leu Cys Arg Gly Leu Thr Ala Ala Gly Leu Val Ala Met Gly Asp 
            900                 905                 910         


Lys Met Ala Ser His Ile Ser Arg Ala Leu Phe Leu Pro Pro Ile Lys 
        915                 920                 925             


Leu Glu Cys Glu Lys Thr Phe Thr Lys Leu Leu Leu Ile Ala Lys Lys 
    930                 935                 940                 


Lys Tyr Ile Gly Val Ile Cys Gly Gly Lys Met Leu Ile Lys Gly Val 
945                 950                 955                 960 


Asp Leu Val Arg Lys Asn Asn Cys Ala Phe Ile Asn Arg Thr Ser Arg 
                965                 970                 975     


Ala Leu Val Asp Leu Leu Phe Tyr Asp Asp Thr Val Ser Gly Ala Ala 
            980                 985                 990         


Ala Ala Leu Ala Glu Arg Pro Ala  Glu Glu Trp Leu Ala  Arg Pro Leu 
        995                 1000                 1005             


Pro Glu  Gly Leu Gln Ala Phe  Gly Ala Val Leu Val  Asp Ala His 
    1010                 1015                 1020             


Arg Arg  Ile Thr Asp Pro Glu  Arg Asp Ile Gln Asp  Phe Val Leu 
    1025                 1030                 1035             


Thr Ala  Glu Leu Ser Arg His  Pro Arg Ala Tyr Thr  Asn Lys Arg 
    1040                 1045                 1050             


Leu Ala  His Leu Thr Val Tyr  Tyr Lys Leu Met Ala  Arg Arg Ala 
    1055                 1060                 1065             


Gln Val  Pro Ser Ile Lys Asp  Arg Ile Pro Tyr Val  Ile Val Ala 
    1070                 1075                 1080             


Gln Thr  Arg Glu Val Glu Glu  Thr Val Ala Arg Leu  Ala Ala Leu 
    1085                 1090                 1095             


Arg Glu  Leu Asp Ala Ala Ala  Pro Gly Asp Glu Pro  Ala Pro Pro 
    1100                 1105                 1110             


Ala Ala  Leu Pro Ser Pro Ala  Lys Arg Pro Arg Glu  Thr Pro Ser 
    1115                 1120                 1125             


His Ala  Asp Pro Pro Gly Gly  Ala Ser Lys Pro Arg  Lys Leu Leu 
    1130                 1135                 1140             


Val Ser  Glu Leu Ala Glu Asp  Pro Gly Tyr Ala Ile  Ala Arg Gly 
    1145                 1150                 1155             


Val Pro  Leu Asn Thr Asp Tyr  Tyr Phe Ser His Leu  Leu Gly Ala 
    1160                 1165                 1170             


Ala Cys  Val Thr Phe Lys Ala  Leu Phe Gly Asn Asn  Ala Lys Ile 
    1175                 1180                 1185             


Thr Glu  Ser Leu Leu Lys Arg  Phe Ile Pro Glu Thr  Trp His Pro 
    1190                 1195                 1200             


Pro Asp  Asp Val Ala Ala Arg  Leu Arg Ala Ala Gly  Phe Gly Pro 
    1205                 1210                 1215             


Ala Gly  Ala Gly Ala Thr Ala  Glu Glu Thr Arg Arg  Met Leu His 
    1220                 1225                 1230             


Arg Ala  Phe Asp Thr Leu Ala  
    1235                 1240 


