                         SEQUENCE LISTING

<110> LamKap Bio beta Ltd.
 
<120> BISPECIFIC ANTIBODIES AGAINST CEACAM5 AND CD47
      
<130> 4130.002PC08

<150> EP18175655.2
<151> 2018-06-03

<150> EP18175656.0
<151> 2018-06-03

<150> EP18175657.8
<151> 2018-06-03

<150> EP18175658.6
<151> 2018-06-03

<150> EP18188788.6
<151> 2018-08-13

<150> EP18188790.2
<151> 2018-08-13

<150> EP18188792.8
<151> 2018-08-13

<150> EP18190983.9
<151> 2018-08-27

<160>  116   

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CD47 CDRH1

<400>  1

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CD47 CDRH2

<400>  2

Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CD47 CDRH3

<400>  3

Ala Lys Ser Tyr Gly Ala Phe Asp Tyr 
1               5                   


<210>  4
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CD47 VH

<400>  4

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Tyr Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  5
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CD47 HC

<400>  5

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Tyr Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210>  6
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mab CD47 HC

<400>  6
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaagttat      300

ggtgcttttg actactgggg ccagggaacc ctggtcacag tctcgagcgc ctccaccaag      360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cagtctcgtg gaactcagga      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgactgt gccctccagc agcttgggca cccagaccta catctgcaac      600

gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac      660

aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtataccctg cccccatctc gggaggagat gaccaagaac     1080

caggtcagcc tgacttgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaacg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctatag caagctcacc gtggacaagt ccaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tccctgtctc cgggttaa                                                   1338


<210>  7
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CD47 CDRL1

<400>  7

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  8
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MabCd47 CDRL2

<400>  8

Ala Ala Ser Ser 
1               


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CD47 CDRL3

<400>  9

Gln Gln Met His Pro Arg Ala Pro Lys Thr 
1               5                   10  


<210>  10
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CD47 VL

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Met His Pro Arg Ala Pro 
                85                  90                  95      


Lys Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  11
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CD47 LC

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Met His Pro Arg Ala Pro 
                85                  90                  95      


Lys Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  12
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mab CD47 LC

<400>  12
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcagcag atgcacccgc gcgccccgaa gaccttcggc      300

caagggacca aggtggaaat caaacgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgttaa                   648


<210>  13
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA CL

<400>  13

Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala 
1               5                   10                  15      


Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn 
            20                  25                  30          


Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val 
        35                  40                  45              


Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu 
    50                  55                  60                  


Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
65                  70                  75                  80  


Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser 
                85                  90                  95      


Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro 
            100                 105                 110         


Thr Glu Cys Ser 
        115     


<210>  14
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  14
gtctgaagca ttatgtgttg aagc                                              24


<210>  15
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  15
gtgagtacat tcattgtact gtg                                               23


<210>  16
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  16
ttgtgtgact cttaactctc agag                                              24


<210>  17
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  17
gaggccactt gtgtagcgcc aagtg                                             25


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  18
gtgagtccat ggctgtcact g                                                 21


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  19
cctgacttgg ctattctcag                                                   20


<210>  20
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA variable heavy chain

<400>  20

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  21
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA variable light chain

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Ala Ala Val Gly Thr Tyr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Lys Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  22
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope of CD3 epsilon

<400>  22

Gln Asp Gly Asn Glu 
1               5   


<210>  23
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CD47 HC-DE

<400>  23

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Tyr Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Asp Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Glu Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210>  24
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CD47 HC-DEA

<400>  24

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Tyr Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Ala Gly Pro Asp Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Glu Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210>  25
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CD47 CDRH1

<400>  25

Ser Tyr Ala Met Ser 
1               5   


<210>  26
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CD47 CHRH2

<400>  26

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CD47 CDRH3

<400>  27

Ser Tyr Gly Ala Phe Asp Tyr 
1               5           


<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CD47 CDRL1; KA3

<400>  28

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CD47 CDRL2; KA3

<400>  29

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  30
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CD47 CDRL3; KA3

<400>  30

Gln Gln Met His Pro Arg Ala Pro Lys Thr 
1               5                   10  


<210>  31
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA CDRL1; 1D9 (AC5)

<400>  31

Ser Gly Ser Ser Ser Asn Ile Gly Tyr Gly Leu Val Ser 
1               5                   10              


<210>  32
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA CDRL2; 1D9 (AC5)

<400>  32

Ala Gly Asn Leu Arg Pro Ser 
1               5           


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA CDRL3; 1D9 (AC5)

<400>  33

Gly Thr Trp Asp Phe Asn Tyr Gly Val Val 
1               5                   10  


<210>  34
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA CDRL1; 1G6 (AC22)

<400>  34

Ser Gly Ser Ser Ser Asn Ile Ala Asn Gly Ile Val Ser 
1               5                   10              


<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA CDRL2; 1G6 (AC22)

<400>  35

Phe Asp Asn Leu Arg Pro Ser 
1               5           


<210>  36
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA CDRL3; 1G6 (AC22)

<400>  36

Gly Thr Trp Asp Phe Ser Tyr Gly Ile Val 
1               5                   10  


<210>  37
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA CDRL1; 1D5 (AC10)

<400>  37

Thr Gly Ser Ser Ser Asn Ile Tyr Ala Asn Ser Asn Val His 
1               5                   10                  


<210>  38
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA CDRL2; 1D5 (AC10)

<400>  38

Ser Gly Ser Asn Arg Pro Ser 
1               5           


<210>  39
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA CDRL3; 1D5 (AC10)

<400>  39

Gln Ser Tyr Asp Pro Ala His Asn Leu Leu Thr Ala Val 
1               5                   10              


<210>  40
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA CDRL1, 2B8 (AC13)

<400>  40

Thr Gly Thr Ser Ser Asn Val Arg Tyr Ala Ala Gly Val Ser 
1               5                   10                  


<210>  41
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA CDRL2; 2B8 (AC13)

<400>  41

Glu Val Ser Asn Arg Pro Ser 
1               5           


<210>  42
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA CDRL3; 2B8 (AC13)

<400>  42

Ser Ser Trp Asp Phe Glu His Gly Pro Ala Ala Lys Val 
1               5                   10              


<210>  43
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA CDRL1; 1A2 (AC18)

<400>  43

Gly Gly Asn Gly Ile Gly Asp Ala Ser Val His 
1               5                   10      


<210>  44
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA CDRL2; 1A2 (AC18)

<400>  44

Ser Thr Thr Thr Arg Pro Ser 
1               5           


<210>  45
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA CDRL3; 1A2 (AC18)

<400>  45

Gln Val Trp Asp Gly Phe Gly Pro Arg His Arg Ala Val 
1               5                   10              


<210>  46
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA CDRL1; 1A8 (AC23)

<400>  46

Ser Gly Ser Ser Ser Asn Ile Gly Tyr Gly Leu Val Asn 
1               5                   10              


<210>  47
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA CDRL2; 1A8 (AC23)

<400>  47

Ala Thr Asn Thr Arg Pro Ser 
1               5           


<210>  48
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA CDRL3; 1A8 (AC23)

<400>  48

Ala Ala Trp Asp Phe Ser Tyr Lys Val Val 
1               5                   10  


<210>  49
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA CDRL1; 2F4 (AC25)

<400>  49

Ser Gly Ser Ser Ser Asn Ile Gly Ile Thr Pro Val Ser 
1               5                   10              


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA CDRL2; 2F4 (AC25)

<400>  50

Ser Asn Asn Phe Arg Pro Ser 
1               5           


<210>  51
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA CDRL3; 2F4 (AC25)

<400>  51

Gly Thr Trp Asp Arg Thr Gly His Glu Ile Arg Pro Val 
1               5                   10              


<210>  52
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA CDRL1; 2F7 (AC26)

<400>  52

Thr Gly Thr Ser Ser Asp Val Lys Tyr Ala Asn Ala Val Ser 
1               5                   10                  


<210>  53
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA CDRL2; 2F7 (AC26)

<400>  53

Ser Asn Ser Ile Arg Pro Ser 
1               5           


<210>  54
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA CDRL3; 2F7 (AC26)

<400>  54

Ser Ser Tyr Asp Pro Arg Gly Asn Leu Leu Ile Arg Val 
1               5                   10              


<210>  55
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA CDRL1; 2C11 (AC27)

<400>  55

Thr Gly Ser Ser Ser Asn Ile Gly Tyr Ala Asp Lys Val His 
1               5                   10                  


<210>  56
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA CDRL2; 2C11 (AC27)

<400>  56

Asn Asn Ser Asp Arg Pro Ser 
1               5           


<210>  57
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA CDRL3; 2C11 (AC27)

<400>  57

Gln Ser Tyr Asp Gly Tyr Asn Met Leu Thr Ala Val 
1               5                   10          


<210>  58
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA CDRL1; C11 (AC28)

<400>  58

Thr Arg Ser Ser Gly Ser Ile Asn Asp Ile Thr Val His 
1               5                   10              


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA CDRL2; C11 (AC28)

<400>  59

Gly Tyr Asn Ala Arg Pro Ser 
1               5           


<210>  60
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA CDRL3; C11 (AC28)

<400>  60

Gln Ser Trp Asp Gly His Gly Ser Ala Tyr Val 
1               5                   10      


<210>  61
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA CDRL1; 2B5 (AC29)

<400>  61

Thr Gly Thr Ser Ser Asp Val Glu Phe Thr Asn Gly Val Ser 
1               5                   10                  


<210>  62
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA CDRL2; 2B5 (AC29)

<400>  62

Gly Phe Ser Ser Arg Pro Ser 
1               5           


<210>  63
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA CDRL3; 2B5 (AC29)

<400>  63

Ser Ser Tyr Asp Pro Pro Trp His Leu Leu Ala Arg Val 
1               5                   10              


<210>  64
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA 1D9 VLCL2 CEA (AC5)

<400>  64

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Tyr Gly 
            20                  25                  30          


Leu Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Gly Asn Leu Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Phe Asn Tyr 
                85                  90                  95      


Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu Cys Ser 
    210                 215 


<210>  65
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA 1G6 VLCL2 CEA (AC22)

<400>  65

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Ala Asn Gly 
            20                  25                  30          


Ile Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Phe Asp Asn Leu Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Phe Ser Tyr 
                85                  90                  95      


Gly Ile Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu Cys Ser 
    210                 215 


<210>  66
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA 1D5 VLCL2 CEA (AC10)

<400>  66

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Tyr Ala Asn 
            20                  25                  30          


Ser Asn Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ser Gly Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Pro Ala 
                85                  90                  95      


His Asn Leu Leu Thr Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            100                 105                 110         


Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
        115                 120                 125             


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
    130                 135                 140                 


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
145                 150                 155                 160 


Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
                165                 170                 175     


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
            180                 185                 190         


Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
        195                 200                 205             


Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215                 


<210>  67
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA 2B8 VLCL2 CEA (AC13)

<400>  67

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asn Val Arg Tyr Ala 
            20                  25                  30          


Ala Gly Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Trp Asp Phe Glu 
                85                  90                  95      


His Gly Pro Ala Ala Lys Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            100                 105                 110         


Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
        115                 120                 125             


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
    130                 135                 140                 


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
145                 150                 155                 160 


Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
                165                 170                 175     


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
            180                 185                 190         


Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
        195                 200                 205             


Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215                 


<210>  68
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA 1A2 VLCL2 CEA (AC18)

<400>  68

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Gly Ile Gly Asp Ala Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Ser Thr Thr Thr Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Gly Phe Gly Pro Arg 
                85                  90                  95      


His Arg Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  69
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA 1A8 VLCL2 CEA (AC23)

<400>  69

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Tyr Gly 
            20                  25                  30          


Leu Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ala Thr Asn Thr Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Phe Ser Tyr 
                85                  90                  95      


Lys Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu Cys Ser 
    210                 215 


<210>  70
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA 2F4 VLCL2 CEA (AC25)

<400>  70

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ile Thr 
            20                  25                  30          


Pro Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Phe Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Arg Thr Gly 
                85                  90                  95      


His Glu Ile Arg Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
        115                 120                 125             


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
    130                 135                 140                 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
145                 150                 155                 160 


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
                165                 170                 175     


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
            180                 185                 190         


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
        195                 200                 205             


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215             


<210>  71
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA 2F4 VLCL2 CEA (AC25)

<400>  71

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Lys Tyr Ala 
            20                  25                  30          


Asn Ala Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Ser Asn Ser Ile Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Asp Pro Arg 
                85                  90                  95      


Gly Asn Leu Leu Ile Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            100                 105                 110         


Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
        115                 120                 125             


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
    130                 135                 140                 


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
145                 150                 155                 160 


Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
                165                 170                 175     


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
            180                 185                 190         


Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
        195                 200                 205             


Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215                 


<210>  72
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA 2C11 VLCL2 CEA

<400>  72

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Tyr Ala 
            20                  25                  30          


Asp Lys Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asn Asn Ser Asp Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Tyr 
                85                  90                  95      


Asn Met Leu Thr Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
        115                 120                 125             


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
    130                 135                 140                 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
145                 150                 155                 160 


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
                165                 170                 175     


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
            180                 185                 190         


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
        195                 200                 205             


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215             


<210>  73
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA C11 VLCL2 CEA (AC28)

<400>  73

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Asn Asp Ile 
            20                  25                  30          


Thr Val His Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 
        35                  40                  45              


Ile Tyr Gly Tyr Asn Ala Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Trp Asp Gly 
                85                  90                  95      


His Gly Ser Ala Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
        115                 120                 125             


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
    130                 135                 140                 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
145                 150                 155                 160 


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
                165                 170                 175     


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
            180                 185                 190         


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
        195                 200                 205             


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215             


<210>  74
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA 2B5 VLCL2 CEA (AC29)

<400>  74

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Glu Phe Thr 
            20                  25                  30          


Asn Gly Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Phe Ser Ser Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Asp Pro Pro 
                85                  90                  95      


Trp His Leu Leu Ala Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            100                 105                 110         


Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
        115                 120                 125             


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
    130                 135                 140                 


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
145                 150                 155                 160 


Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
                165                 170                 175     


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
            180                 185                 190         


Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
        195                 200                 205             


Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215                 


<210>  75
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid 1D9 VLCL2 CEA (AC5)

<400>  75
cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcagctc caacattggt tatgggcttg tatcctggta ccagcagctc      120

ccaggaacag cccccaaact cctcatttat gctggtaatc ttcgaccctc agggattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tgggcatcac cggactccag      240

actggggacg aggccgatta ttactgcgga acatgggatt ttaattatgg ggttgtgttc      300

ggcggaggga ccaagctgac cgtcctaggt cagcccaagg ctgccccctc ggtcactctg      360

ttcccgccct cctctgagga gcttcaagcc aacaaggcca cactggtgtg tctcataagt      420

gacttctacc cgggagccgt gacagtggct tggaaagcag atagcagccc cgtcaaggcg      480

ggagtggaga ccaccacacc ctccaaacaa agcaacaaca agtacgcggc cagcagctat      540

ctgagcctga cgcctgagca gtggaagtcc cacagaagct acagctgcca ggtcacgcat      600

gaagggagca ccgtggagaa gacagtggcc cctacagaat gttcataa                   648


<210>  76
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid 1G6 VLCL2 CEA (AC22)

<400>  76
cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcagctc caacattgct aatgggattg tatcctggta ccagcagctc      120

ccaggaacag cccccaaact cctcatttat tttgataatc ttcgaccctc agggattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tgggcatcac cggactccag      240

actggggacg aggccgatta ttactgcgga acatgggatt ttagttatgg tattgtgttc      300

ggcggaggga ccaagctgac cgtcctaggt cagcccaagg ctgccccctc ggtcactctg      360

ttcccgccct cctctgagga gcttcaagcc aacaaggcca cactggtgtg tctcataagt      420

gacttctacc cgggagccgt gacagtggct tggaaagcag atagcagccc cgtcaaggcg      480

ggagtggaga ccaccacacc ctccaaacaa agcaacaaca agtacgcggc cagcagctat      540

ctgagcctga cgcctgagca gtggaagtcc cacagaagct acagctgcca ggtcacgcat      600

gaagggagca ccgtggagaa gacagtggcc cctacagaat gttcataa                   648


<210>  77
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid 1D5 VLCL2 CEA (AC10)

<400>  77
cagtctgtgc tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatctat gcgaatagta atgtacactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tattctggta gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg atcccgcgca caacttgctc      300

actgctgtgt tcggcggagg gaccaagctg accgtcctag gtcagcccaa ggctgccccc      360

tcggtcactc tgttcccgcc ctcctctgag gagcttcaag ccaacaaggc cacactggtg      420

tgtctcataa gtgacttcta cccgggagcc gtgacagtgg cttggaaagc agatagcagc      480

cccgtcaagg cgggagtgga gaccaccaca ccctccaaac aaagcaacaa caagtacgcg      540

gccagcagct atctgagcct gacgcctgag cagtggaagt cccacagaag ctacagctgc      600

caggtcacgc atgaagggag caccgtggag aagacagtgg cccctacaga atgttcataa      660


<210>  78
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid 2B8 VLCL2 CEA (AC13)

<400>  78
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag taatgttagg tatgctgctg gtgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tatgaggtca gtaatcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatggg attttgagca tggtcctgct      300

gctaaggtgt tcggcggagg gaccaagctg accgtcctag gtcagcccaa ggctgccccc      360

tcggtcactc tgttcccgcc ctcctctgag gagcttcaag ccaacaaggc cacactggtg      420

tgtctcataa gtgacttcta cccgggagcc gtgacagtgg cttggaaagc agatagcagc      480

cccgtcaagg cgggagtgga gaccaccaca ccctccaaac aaagcaacaa caagtacgcg      540

gccagcagct atctgagcct gacgcctgag cagtggaagt cccacagaag ctacagctgc      600

caggtcacgc atgaagggag caccgtggag aagacagtgg cccctacaga atgttcataa      660


<210>  79
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid 1A2 VLCL2 CEA

<400>  79
tcctatgtgc tgactcagcc accctcagtg tcagtggccc caggaaagac ggccaggatt       60

acctgtgggg gaaacggtat tggagatgcg tctgtgcact ggtaccagca gaagccaggc      120

caggcccctg tgctggtcat ctattctact actacgcggc cctcagggat tcctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgtgg gatgggtttg gtcctaggca tagggctgtg      300

ttcggcggag ggaccaagct gaccgtccta ggtcagccca aggctgcccc ctcggtcact      360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      420

agtgacttct acccgggagc cgtgacagtg gcttggaaag cagatagcag ccccgtcaag      480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      540

tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttcata a               651


<210>  80
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid 1A8 VLCL2 CEA (AC23)

<400>  80
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcggg tatgggcttg taaactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat gctactaata cgcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag      240

tctgaggatg aggctgatta ttactgtgca gcatgggatt ttagttataa ggttgtgttc      300

ggcggaggga ccaagctgac cgtcctaggt cagcccaagg ctgccccctc ggtcactctg      360

ttcccgccct cctctgagga gcttcaagcc aacaaggcca cactggtgtg tctcataagt      420

gacttctacc cgggagccgt gacagtggct tggaaagcag atagcagccc cgtcaaggcg      480

ggagtggaga ccaccacacc ctccaaacaa agcaacaaca agtacgcggc cagcagctat      540

ctgagcctga cgcctgagca gtggaagtcc cacagaagct acagctgcca ggtcacgcat      600

gaagggagca ccgtggagaa gacagtggcc cctacagaat gttcataa                   648


<210>  81
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid 2F4 VLCL2 CEA (AC25)

<400>  81
cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcagctc caacattggt attacgcctg tatcctggta ccagcagctc      120

ccaggaacag cccccaaact cctcatttat tctaataatt ttcgaccctc agggattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tgggcatcac cggactccag      240

actggggacg aggccgatta ttactgcgga acatgggata ggactggtca tgagattagg      300

cctgtgttcg gcggagggac caagctgacc gtcctaggtc agcccaaggc tgccccctcg      360

gtcactctgt tcccgccctc ctctgaggag cttcaagcca acaaggccac actggtgtgt      420

ctcataagtg acttctaccc gggagccgtg acagtggctt ggaaagcaga tagcagcccc      480

gtcaaggcgg gagtggagac caccacaccc tccaaacaaa gcaacaacaa gtacgcggcc      540

agcagctatc tgagcctgac gcctgagcag tggaagtccc acagaagcta cagctgccag      600

gtcacgcatg aagggagcac cgtggagaag acagtggccc ctacagaatg ttcataa         657


<210>  82
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid 2F7 VLCL2 CEA

<400>  82
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttaag tatgcgaatg cggtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tattctaata gtattcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatatg atccccgggg caacctcctg      300

atcagggtgt tcggcggagg gaccaagctg accgtcctag gtcagcccaa ggctgccccc      360

tcggtcactc tgttcccgcc ctcctctgag gagcttcaag ccaacaaggc cacactggtg      420

tgtctcataa gtgacttcta cccgggagcc gtgacagtgg cttggaaagc agatagcagc      480

cccgtcaagg cgggagtgga gaccaccaca ccctccaaac aaagcaacaa caagtacgcg      540

gccagcagct atctgagcct gacgcctgag cagtggaagt cccacagaag ctacagctgc      600

caggtcacgc atgaagggag caccgtggag aagacagtgg cccctacaga atgttcataa      660


<210>  83
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid 2C11 VLCL2 CEA (AC27)

<400>  83
cagtctgtgc tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggt tatgctgata aggtacactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tataataata gcgatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg atggctacaa catgctgact      300

gctgtgttcg gcggagggac caagctgacc gtcctaggtc agcccaaggc tgccccctcg      360

gtcactctgt tcccgccctc ctctgaggag cttcaagcca acaaggccac actggtgtgt      420

ctcataagtg acttctaccc gggagccgtg acagtggctt ggaaagcaga tagcagcccc      480

gtcaaggcgg gagtggagac caccacaccc tccaaacaaa gcaacaacaa gtacgcggcc      540

agcagctatc tgagcctgac gcctgagcag tggaagtccc acagaagcta cagctgccag      600

gtcacgcatg aagggagcac cgtggagaag acagtggccc ctacagaatg ttcataa         657


<210>  84
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid C11 VLCL2 CEA (AC28)

<400>  84
aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac ggtaaccatc       60

tcctgcaccc gcagcagtgg cagcatcaat gatattacgg tgcattggta ccagcagcgc      120

ccgggcagtt cccccaccac tgtgatctat gggtataacg cgagaccctc tggggtccct      180

gatcggttct ctggctccat cgacagctcc tccaactctg cctccctcac catctctgga      240

ctgaagactg aggacgaggc tgactactac tgtcagtcct gggatgggca tggttctgcg      300

tatgtgttcg gcggagggac caagctgacc gtcctaggtc agcccaaggc tgccccctcg      360

gtcactctgt tcccgccctc ctctgaggag cttcaagcca acaaggccac actggtgtgt      420

ctcataagtg acttctaccc gggagccgtg acagtggctt ggaaagcaga tagcagcccc      480

gtcaaggcgg gagtggagac caccacaccc tccaaacaaa gcaacaacaa gtacgcggcc      540

agcagctatc tgagcctgac gcctgagcag tggaagtccc acagaagcta cagctgccag      600

gtcacgcatg aagggagcac cgtggagaag acagtggccc ctacagaatg ttcataa         657


<210>  85
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid 2B5 VLCL2 CEA (AC29)

<400>  85
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttgag tttacgaatg gtgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tatggtttta gtagtcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatatg atcccccctg gcacctgctg      300

gctagggtgt tcggcggagg gaccaagctg accgtcctag gtcagcccaa ggctgccccc      360

tcggtcactc tgttcccgcc ctcctctgag gagcttcaag ccaacaaggc cacactggtg      420

tgtctcataa gtgacttcta cccgggagcc gtgacagtgg cttggaaagc agatagcagc      480

cccgtcaagg cgggagtgga gaccaccaca ccctccaaac aaagcaacaa caagtacgcg      540

gccagcagct atctgagcct gacgcctgag cagtggaagt cccacagaag ctacagctgc      600

caggtcacgc atgaagggag caccgtggag aagacagtgg cccctacaga atgttcataa      660


<210>  86
<211>  2109
<212>  DNA
<213>  Homo sapiens

<400>  86
atggagtctc cctcggcccc tccccacaga tggtgcatcc cctggcagag gctcctgctc       60

acagcctcac ttctaacctt ctggaacccg cccaccactg ccaagctcac tattgaatcc      120

acgccgttca atgtcgcaga ggggaaggag gtgcttctac ttgtccacaa tctgccccag      180

catctttttg gctacagctg gtacaaaggt gaaagagtgg atggcaaccg tcaaattata      240

ggatatgtaa taggaactca acaagctacc ccagggcccg catacagtgg tcgagagata      300

atatacccca atgcatccct gctgatccag aacatcatcc agaatgacac aggattctac      360

accctacacg tcataaagtc agatcttgtg aatgaagaag caactggcca gttccgggta      420

tacccggagc tgcccaagcc ctccatctcc agcaacaact ccaaacccgt ggaggacaag      480

gatgctgtgg ccttcacctg tgaacctgag actcaggacg caacctacct gtggtgggta      540

aacaatcaga gcctcccggt cagtcccagg ctgcagctgt ccaatggcaa caggaccctc      600

actctattca atgtcacaag aaatgacaca gcaagctaca aatgtgaaac ccagaaccca      660

gtgagtgcca ggcgcagtga ttcagtcatc ctgaatgtcc tctatggccc ggatgccccc      720

accatttccc ctctaaacac atcttacaga tcaggggaaa atctgaacct ctcctgccac      780

gcagcctcta acccacctgc acagtactct tggtttgtca atgggacttt ccagcaatcc      840

acccaagagc tctttatccc caacatcact gtgaataata gtggatccta tacgtgccaa      900

gcccataact cagacactgg cctcaatagg accacagtca cgacgatcac agtctatgca      960

gagccaccca aacccttcat caccagcaac aactccaacc ccgtggagga tgaggatgct     1020

gtagccttaa cctgtgaacc tgagattcag aacacaacct acctgtggtg ggtaaataat     1080

cagagcctcc cggtcagtcc caggctgcag ctgtccaatg acaacaggac cctcactcta     1140

ctcagtgtca caaggaatga tgtaggaccc tatgagtgtg gaatccagaa caaattaagt     1200

gttgaccaca gcgacccagt catcctgaat gtcctctatg gcccagacga ccccaccatt     1260

tccccctcat acacctatta ccgtccaggg gtgaacctca gcctctcctg ccatgcagcc     1320

tctaacccac ctgcacagta ttcttggctg attgatggga acatccagca acacacacaa     1380

gagctcttta tctccaacat cactgagaag aacagcggac tctatacctg ccaggccaat     1440

aactcagcca gtggccacag caggactaca gtcaagacaa tcacagtctc tgcggagctg     1500

cccaagccct ccatctccag caacaactcc aaacccgtgg aggacaagga tgctgtggcc     1560

ttcacctgtg aacctgaggc tcagaacaca acctacctgt ggtgggtaaa tggtcagagc     1620

ctcccagtca gtcccaggct gcagctgtcc aatggcaaca ggaccctcac tctattcaat     1680

gtcacaagaa atgacgcaag agcctatgta tgtggaatcc agaactcagt gagtgcaaac     1740

cgcagtgacc cagtcaccct ggatgtcctc tatgggccgg acacccccat catttccccc     1800

ccagactcgt cttacctttc gggagcgaac ctcaacctct cctgccactc ggcctctaac     1860

ccatccccgc agtattcttg gcgtatcaat gggataccgc agcaacacac acaagttctc     1920

tttatcgcca aaatcacgcc aaataataac gggacctatg cctgttttgt ctctaacttg     1980

gctactggcc gcaataattc catagtcaag agcatcacag tctctgcatc tggaacttct     2040

cctggtctct cagctggggc cactgtcggc atcatgattg gagtgctggt tggggttgct     2100

ctgatataa                                                             2109


<210>  87
<211>  702
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 
            100                 105                 110         


Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg 
    210                 215                 220                 


Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala 
305                 310                 315                 320 


Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu 
                325                 330                 335     


Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr 
            340                 345                 350         


Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg 
        355                 360                 365             


Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr 
    370                 375                 380                 


Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Lys Leu Ser 
385                 390                 395                 400 


Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp 
                405                 410                 415     


Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn 
            420                 425                 430         


Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser 
        435                 440                 445             


Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile 
    450                 455                 460                 


Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn 
465                 470                 475                 480 


Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val 
                485                 490                 495     


Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro 
            500                 505                 510         


Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln 
        515                 520                 525             


Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser 
    530                 535                 540                 


Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn 
545                 550                 555                 560 


Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser 
                565                 570                 575     


Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly 
            580                 585                 590         


Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly 
        595                 600                 605             


Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln 
    610                 615                 620                 


Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu 
625                 630                 635                 640 


Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe 
                645                 650                 655     


Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile 
            660                 665                 670         


Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr 
        675                 680                 685             


Val Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile 
    690                 695                 700         


<210>  88
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAB CEA1 VH

<400>  88

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Ser Lys Tyr Val Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Phe Gly Tyr Tyr Val Ser Asp Tyr Ala Met Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  89
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAB CEA1 VL

<400>  89

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Gly Glu Ser Val Asp Ile Phe 
            20                  25                  30          


Gly Val Gly Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Arg Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Thr Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  90
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAB CD3 VH

<400>  90

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  91
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAB CD3 VL

<400>  91

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Ala Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  92
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 VH-CL(CK)

<400>  92

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Val 
        115                 120                 125             


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
    130                 135                 140                 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
145                 150                 155                 160 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
                165                 170                 175     


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
        195                 200                 205             


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
    210                 215                 220                 


Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230         


<210>  93
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEA VH-CH1(EE)-Fc (hole, P329G LALA)

<400>  93

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Ser Lys Tyr Val Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Phe Gly Tyr Tyr Val Ser Asp Tyr Ala Met Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Glu Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Glu Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro 
    


<210>  94
<211>  614
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEA VH-CH1(EE)-CD3 VL-CH1-Fc (knob, P329G LALA)

<400>  94

Val Pro Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr 
1               5                   10                  15      


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
            20                  25                  30          


Val Tyr Tyr Cys Ala Pro Phe Gly Tyr Tyr Val Ser Asp Tyr Ala Met 
        35                  40                  45              


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    50                  55                  60                  


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
65                  70                  75                  80  


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Glu Asp Tyr Phe Pro Glu 
                85                  90                  95      


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            100                 105                 110         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        115                 120                 125             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    130                 135                 140                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Glu Lys Val Glu 
145                 150                 155                 160 


Pro Lys Ser Cys Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
                165                 170                 175     


Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr 
            180                 185                 190         


Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser Asn 
        195                 200                 205             


Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Ala Phe Arg Gly Leu 
    210                 215                 220                 


Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe Ser 
225                 230                 235                 240 


Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala Gln 
                245                 250                 255     


Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn Leu 
            260                 265                 270         


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Ser Ala Ser 
        275                 280                 285             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    290                 295                 300                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
305                 310                 315                 320 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                325                 330                 335     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            340                 345                 350         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        355                 360                 365             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    370                 375                 380                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
385                 390                 395                 400 


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                405                 410                 415     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            420                 425                 430         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        435                 440                 445             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    450                 455                 460                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
465                 470                 475                 480 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                485                 490                 495     


Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            500                 505                 510         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
        515                 520                 525             


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    530                 535                 540                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
545                 550                 555                 560 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                565                 570                 575     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            580                 585                 590         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        595                 600                 605             


Ser Leu Ser Leu Ser Pro 
    610                 


<210>  95
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEA VL-CL(RK)

<400>  95

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Gly Glu Ser Val Asp Ile Phe 
            20                  25                  30          


Gly Val Gly Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Arg Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Thr Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Arg Lys 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  96
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CD3 CH2527 Cross Fab VL-CH1

<400>  96

Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Ala Phe Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Ser Ala 
            100                 105                 110         


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
        115                 120                 125             


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
    130                 135                 140                 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
145                 150                 155                 160 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
                165                 170                 175     


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
            180                 185                 190         


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
        195                 200                 205             


Val Glu Pro Lys Ser Cys 
    210                 


<210>  97
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEA CH1A10 VH CH1 FC Hole P329G LALA

<400>  97

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  98
<211>  694
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEA CH1A1A CD3 CH2527 Cross Fab VH-CK FC Knob P329G LALA

<400>  98

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu 
225                 230                 235                 240 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                245                 250                 255     


Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr Ala Met Asn Trp Val 
            260                 265                 270         


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Arg Ile Arg Ser 
        275                 280                 285             


Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    290                 295                 300                 


Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met 
305                 310                 315                 320 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg His 
                325                 330                 335     


Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr Trp Gly Gln 
            340                 345                 350         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Val Ala Ala Pro Ser Val 
        355                 360                 365             


Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser 
    370                 375                 380                 


Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
385                 390                 395                 400 


Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val 
                405                 410                 415     


Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu 
            420                 425                 430         


Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu 
        435                 440                 445             


Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg 
    450                 455                 460                 


Gly Glu Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
465                 470                 475                 480 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                485                 490                 495     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            500                 505                 510         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        515                 520                 525             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    530                 535                 540                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
545                 550                 555                 560 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly 
                565                 570                 575     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            580                 585                 590         


Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn 
        595                 600                 605             


Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    610                 615                 620                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
625                 630                 635                 640 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                645                 650                 655     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            660                 665                 670         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        675                 680                 685             


Ser Leu Ser Pro Gly Lys 
    690                 


<210>  99
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CEA 2F1 84

<400>  99

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Ala Ala Val Gly Thr Tyr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Lys Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  100
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VK_SM3E

<400>  100

Glu Asn Val Leu Thr Gln Ser Pro Ser Ser Met Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Asn Ile Ala Cys Ser Ala Ser Ser Ser Val Pro Tyr Met 
            20                  25                  30          


His Trp Leu Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Val Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  101
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH_SM3E

<400>  101

Gln Val Lys Leu Glu Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Ser 
            20                  25                  30          


Tyr Met His Trp Leu Arg Gln Gly Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gly Leu Ser Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  102
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL_MEDI

<400>  102

Gln Ala Val Leu Thr Gln Pro Ala Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Ser Ala Ser Leu Thr Cys Thr Leu Arg Arg Gly Ile Asn Val Gly Ala 
            20                  25                  30          


Tyr Ser Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr 
        35                  40                  45              


Leu Leu Arg Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val 
    50                  55                  60                  


Ser Ser Arg Phe Ser Ala Ser Lys Asp Ala Ser Ala Asn Ala Gly Ile 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Met Ile Trp His Ser Gly Ala Ser Ala Val Phe Gly Gly Gly Thr Lys 
            100                 105                 110         


Leu Thr Val Leu 
        115     


<210>  103
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH_MEDI

<400>  103

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Asn Lys Ala Asn Gly Gly Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Arg Gly Leu Arg Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  104
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VK_SAR

<400>  104

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Phe Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Thr Arg Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  105
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH_SAR

<400>  105

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Val Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Gly Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Tyr Phe Gly Ser Ser Gly Pro Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  106
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VK_CH1A1A

<400>  106

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Ala Ala Val Gly Thr Tyr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Lys Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Tyr Thr Tyr Pro Leu 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  107
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH_ CH1A1A

<400>  107

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Phe 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Lys Thr Gly Glu Ala Thr Tyr Val Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Phe Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Asp Phe Ala Tyr Tyr Val Glu Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  108
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VK_T84.66

<400>  108

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Gly Glu Ser Val Asp Ile Phe 
            20                  25                  30          


Gly Val Gly Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Arg Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Thr Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  109
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH_T84.66

<400>  109

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Ser Lys Tyr Val Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Phe Gly Tyr Tyr Val Ser Asp Tyr Ala Met Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  110
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VK_LABETUZUMAB

<400>  110

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ser 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Thr Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Leu Tyr Arg Ser 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  111
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH_LABETUZUMAB

<400>  111

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Asp Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile His Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Ser Leu Tyr Phe Gly Phe Pro Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Pro Val Thr Val Ser Ser 
        115                 


<210>  112
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA 1B2 (AC39) CDRL1

<400>  112

Ser Gly Ser Ser Ser Glu Ile Thr Ala Ser Gly Val Ser 
1               5                   10              


<210>  113
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA 1B2 (AC39) CDRL2

<400>  113

Asp Asn Asn Lys Arg Pro Ser 
1               5           


<210>  114
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA 1B2 (AC39) CDRL3

<400>  114

Gly Thr Trp Asp Phe Pro Pro Ser Arg Phe Val 
1               5                   10      


<210>  115
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mab CEA 1B2 (AC39) VLCL2

<400>  115

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Glu Ile Thr Ala Ser 
            20                  25                  30          


Gly Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Phe Pro Pro 
                85                  90                  95      


Ser Arg Phe Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  116
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mab CEA 1B2 (AC39) VLCL2, nucleic acid

<400>  116
cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcagctc cgagattact gcgtctggtg tatcctggta ccagcagctc      120

ccaggaacag cccccaaact cctcatttat gacaataata agcgaccctc agggattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tgggcatcac cggactccag      240

actggggacg aggccgatta ttactgcgga acatgggatt tcccgccgtc caggttcgtg      300

ttcggcggag ggaccaagct gaccgtccta ggtcagccca aggctgcccc ctcggtcact      360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      420

agtgacttct acccgggagc cgtgacagtg gcttggaaag cagatagcag ccccgtcaag      480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      540

tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttcata a               651


