                         SEQUENCE LISTING

<110>  Howard Hughes Medical Institute
 
<120>  INVERTED TRANSPORTER POLYPEPTIDES AND METHODS OF USING

<130>  30872-0021WO1

<140>  PCT/US2019/035344
<141>  2019-06-04

<150>  US 62/680,130
<151>  2018-06-04

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  309
<212>  PRT
<213>  Chlamydomonas reinhardtii

<400>  1

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Arg Glu Leu Leu Phe 
1               5                   10                  15      


Val Thr Asn Pro Val Val Val Asn Gly Ser Val Leu Val Pro Glu Asp 
            20                  25                  30          


Gln Cys Tyr Cys Ala Gly Trp Ile Glu Ser Arg Gly Thr Asn Gly Ala 
        35                  40                  45              


Gln Thr Ala Ser Asn Val Leu Gln Trp Leu Ala Ala Gly Phe Ser Ile 
    50                  55                  60                  


Leu Leu Leu Met Phe Tyr Ala Tyr Gln Thr Trp Lys Ser Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Glu Ile Tyr Val Cys Ala Ile Glu Met Val Lys Val Ile Leu 
                85                  90                  95      


Glu Phe Phe Phe Glu Phe Lys Asn Pro Ser Met Leu Tyr Leu Ala Thr 
            100                 105                 110         


Gly His Arg Val Gln Trp Leu Arg Tyr Ala Glu Trp Leu Leu Thr Cys 
        115                 120                 125             


Pro Val Ile Leu Ile His Leu Ser Asn Leu Thr Gly Leu Ser Asn Asp 
    130                 135                 140                 


Tyr Ser Arg Arg Thr Met Gly Leu Leu Val Ser Asp Ile Gly Thr Ile 
145                 150                 155                 160 


Val Trp Gly Ala Thr Ser Ala Met Ala Thr Gly Tyr Val Lys Val Ile 
                165                 170                 175     


Phe Phe Cys Leu Gly Leu Cys Tyr Gly Ala Asn Thr Phe Phe His Ala 
            180                 185                 190         


Ala Lys Ala Tyr Ile Glu Gly Tyr His Thr Val Pro Lys Gly Arg Cys 
        195                 200                 205             


Arg Gln Val Val Thr Gly Met Ala Trp Leu Phe Phe Val Ser Trp Gly 
    210                 215                 220                 


Met Phe Pro Ile Leu Phe Ile Leu Gly Pro Glu Gly Phe Gly Val Leu 
225                 230                 235                 240 


Ser Val Tyr Gly Ser Thr Val Gly His Thr Ile Ile Asp Leu Met Ser 
                245                 250                 255     


Lys Asn Cys Trp Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His 
            260                 265                 270         


Glu His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Lys Leu Asn 
        275                 280                 285             


Ile Gly Gly Thr Glu Ile Glu Val Glu Thr Leu Val Glu Asp Glu Ala 
    290                 295                 300                 


Glu Ala Gly Ala Val 
305                 


<210>  2
<211>  345
<212>  PRT
<213>  artificial

<220>
<223>  synthetic CsChrimson construct

<400>  2

Met Ser Arg Leu Val Ala Ala Ser Trp Leu Leu Ala Leu Leu Leu Cys 
1               5                   10                  15      


Gly Ile Thr Ser Thr Thr Thr Ala Ser Ser Ala Pro Ala Ala Ser Ser 
            20                  25                  30          


Thr Asp Gly Thr Ala Ala Ala Ala Val Ser His Tyr Ala Met Asn Gly 
        35                  40                  45              


Phe Asp Glu Leu Ala Lys Gly Ala Val Val Pro Glu Asp His Phe Val 
    50                  55                  60                  


Cys Gly Pro Ala Asp Lys Cys Tyr Cys Ser Ala Trp Leu His Ser Arg 
65                  70                  75                  80  


Gly Thr Pro Gly Glu Lys Ile Gly Ala Gln Val Cys Gln Trp Ile Ala 
                85                  90                  95      


Phe Ser Ile Ala Ile Ala Leu Leu Thr Phe Tyr Gly Phe Ser Ala Trp 
            100                 105                 110         


Lys Ala Thr Cys Gly Trp Glu Glu Val Tyr Val Cys Cys Val Glu Val 
        115                 120                 125             


Leu Phe Val Thr Leu Glu Ile Phe Lys Glu Phe Ser Ser Pro Ala Thr 
    130                 135                 140                 


Val Tyr Leu Ser Thr Gly Asn His Ala Tyr Cys Leu Arg Tyr Phe Glu 
145                 150                 155                 160 


Trp Leu Leu Ser Cys Pro Val Ile Leu Ile Lys Leu Ser Asn Leu Ser 
                165                 170                 175     


Gly Leu Lys Asn Asp Tyr Ser Lys Arg Thr Met Gly Leu Ile Val Ser 
            180                 185                 190         


Cys Val Gly Met Ile Val Phe Gly Met Ala Ala Gly Leu Ala Thr Asp 
        195                 200                 205             


Trp Leu Lys Trp Leu Leu Tyr Ile Val Ser Cys Ile Tyr Gly Gly Tyr 
    210                 215                 220                 


Met Tyr Phe Gln Ala Ala Lys Cys Tyr Val Glu Ala Asn His Ser Val 
225                 230                 235                 240 


Pro Lys Gly His Cys Arg Met Val Val Lys Leu Met Ala Tyr Ala Tyr 
                245                 250                 255     


Phe Ala Ser Trp Gly Ser Tyr Pro Ile Leu Trp Ala Val Gly Pro Glu 
            260                 265                 270         


Gly Leu Leu Lys Leu Ser Pro Tyr Ala Asn Ser Ile Gly His Ser Ile 
        275                 280                 285             


Cys Asp Ile Ile Ala Lys Glu Phe Trp Thr Phe Leu Ala His His Leu 
    290                 295                 300                 


Arg Ile Lys Ile His Glu His Ile Leu Ile His Gly Asp Ile Arg Lys 
305                 310                 315                 320 


Thr Thr Lys Met Glu Ile Gly Gly Glu Glu Val Glu Val Glu Glu Phe 
                325                 330                 335     


Val Glu Glu Glu Asp Glu Asp Thr Val 
            340                 345 


<210>  3
<211>  152
<212>  PRT
<213>  artificial

<220>
<223>  leader sequence

<400>  3

Met Tyr Gln Arg Met Leu Arg Cys Gly Ala Glu Leu Gly Ser Pro Gly 
1               5                   10                  15      


Gly Gly Ser Ser Gly Gly Ala Gly Gly Arg Leu Ala Leu Leu Trp Ile 
            20                  25                  30          


Val Pro Leu Thr Leu Ser Gly Leu Leu Gly Val Ala Trp Gly Ala Ser 
        35                  40                  45              


Ser Leu Gly Ala His His Ile His His Lys Leu Glu Gln Lys Leu Ile 
    50                  55                  60                  


Ser Glu Glu Asp Leu Gly Gly Leu Ala Asn Pro Thr Arg Val Gly Gly 
65                  70                  75                  80  


Arg Glu Pro Tyr Pro Gly Ser Ala Glu Val Ile Arg Glu Ser Ser Ser 
                85                  90                  95      


Thr Thr Gly Met Val Val Gly Ile Val Ala Ala Ala Ala Leu Cys Ile 
            100                 105                 110         


Leu Ile Leu Leu Tyr Ala Met Lys Lys Arg Arg Ala Lys Gly Gly Ser 
        115                 120                 125             


Gly Gly Ser Gly Gly Leu Glu His Gly Thr Ile Pro Phe Asn Arg Thr 
    130                 135                 140                 


His Arg Ser Lys Arg Ser Ser Gly 
145                 150         


<210>  4
<211>  393
<212>  PRT
<213>  artificial

<220>
<223>  leader sequence

<400>  4

Met Ser Ala Thr Ala Ala Thr Val Pro Pro Ala Ala Pro Ala Gly Glu 
1               5                   10                  15      


Gly Gly Pro Pro Ala Pro Pro Pro Asn Leu Thr Ser Asn Arg Arg Leu 
            20                  25                  30          


Gln Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile Met Arg Val 
        35                  40                  45              


Asn Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp 
    50                  55                  60                  


Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser 
65                  70                  75                  80  


Ala Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Leu Lys Met Met 
                85                  90                  95      


Ile Ile Leu Gly Val Ile Cys Ala Ile Ile Leu Ile Ile Ile Ile Val 
            100                 105                 110         


Tyr Phe Ser Thr Gly Gly Ser Gly Gly Ser Arg Gly Val Gln Val Glu 
        115                 120                 125             


Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr 
    130                 135                 140                 


Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp 
145                 150                 155                 160 


Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln 
                165                 170                 175     


Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly 
            180                 185                 190         


Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr 
        195                 200                 205             


Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val 
    210                 215                 220                 


Glu Leu Leu Lys Leu Glu Thr Arg Gly Val Gln Val Glu Thr Ile Ser 
225                 230                 235                 240 


Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val 
                245                 250                 255     


His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg 
            260                 265                 270         


Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile 
        275                 280                 285             


Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala 
    290                 295                 300                 


Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro 
305                 310                 315                 320 


Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu 
                325                 330                 335     


Lys Leu Glu Ser Ala Glu Gln Lys Ile Ser Glu Glu Asp Lys Glu Gln 
            340                 345                 350         


Lys Ile Ser Glu Glu Asp Lys Gly Thr Ser Ala Arg Asn Arg Gln Lys 
        355                 360                 365             


Arg Ala Ser Gly Thr Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp 
    370                 375                 380                 


Val Glu Glu Asn Pro Gly Pro Ser Gly 
385                 390             


<210>  5
<211>  707
<212>  PRT
<213>  artificial

<220>
<223>  inverted transporter polypeptide

<400>  5

Met Tyr Gln Arg Met Leu Arg Cys Gly Ala Glu Leu Gly Ser Pro Gly 
1               5                   10                  15      


Gly Gly Ser Ser Gly Gly Ala Gly Gly Arg Leu Ala Leu Leu Trp Ile 
            20                  25                  30          


Val Pro Leu Thr Leu Ser Gly Leu Leu Gly Val Ala Trp Gly Ala Ser 
        35                  40                  45              


Ser Leu Gly Ala His His Ile His His Lys Leu Glu Gln Lys Leu Ile 
    50                  55                  60                  


Ser Glu Glu Asp Leu Gly Gly Leu Ala Asn Pro Thr Arg Val Gly Gly 
65                  70                  75                  80  


Arg Glu Pro Tyr Pro Gly Ser Ala Glu Val Ile Arg Glu Ser Ser Ser 
                85                  90                  95      


Thr Thr Gly Met Val Val Gly Ile Val Ala Ala Ala Ala Leu Cys Ile 
            100                 105                 110         


Leu Ile Leu Leu Tyr Ala Met Lys Lys Arg Arg Ala Lys Gly Gly Ser 
        115                 120                 125             


Gly Gly Ser Gly Gly Leu Glu His Gly Thr Ile Pro Phe Asn Arg Thr 
    130                 135                 140                 


His Arg Ser Lys Arg Ser Ser Gly Met Asp Tyr Gly Gly Ala Leu Ser 
145                 150                 155                 160 


Ala Val Gly Arg Glu Leu Leu Phe Val Thr Asn Pro Val Val Val Asn 
                165                 170                 175     


Gly Ser Val Leu Val Pro Glu Asp Gln Cys Tyr Cys Ala Gly Trp Ile 
            180                 185                 190         


Glu Ser Arg Gly Thr Asn Gly Ala Gln Thr Ala Ser Asn Val Leu Gln 
        195                 200                 205             


Trp Leu Ala Ala Gly Phe Ser Ile Leu Leu Leu Met Phe Tyr Ala Tyr 
    210                 215                 220                 


Gln Thr Trp Lys Ser Thr Cys Gly Trp Glu Glu Ile Tyr Val Cys Ala 
225                 230                 235                 240 


Ile Glu Met Val Lys Val Ile Leu Glu Phe Phe Phe Glu Phe Lys Asn 
                245                 250                 255     


Pro Ser Met Leu Tyr Leu Ala Thr Gly His Arg Val Gln Trp Leu Arg 
            260                 265                 270         


Tyr Ala Thr Trp Leu Leu Thr Cys Pro Val Ile Leu Ile His Leu Ser 
        275                 280                 285             


Asn Leu Thr Gly Leu Ser Asn Asp Tyr Ser Arg Arg Thr Met Gly Leu 
    290                 295                 300                 


Leu Val Ser Asp Ile Gly Cys Ile Val Trp Gly Ala Thr Ser Ala Met 
305                 310                 315                 320 


Ala Thr Gly Tyr Val Lys Val Ile Phe Phe Cys Leu Gly Leu Cys Tyr 
                325                 330                 335     


Gly Ala Asn Thr Phe Phe His Ala Ala Lys Ala Tyr Ile Glu Gly Tyr 
            340                 345                 350         


His Thr Val Pro Lys Gly Arg Cys Arg Gln Val Val Thr Gly Met Ala 
        355                 360                 365             


Trp Leu Phe Phe Val Ser Trp Gly Met Phe Pro Ile Leu Phe Ile Leu 
    370                 375                 380                 


Gly Pro Glu Gly Phe Gly Val Leu Ser Val Tyr Gly Ser Thr Val Gly 
385                 390                 395                 400 


His Thr Ile Ile Asp Leu Met Ser Lys Asn Cys Trp Gly Leu Leu Gly 
                405                 410                 415     


His Tyr Leu Arg Val Leu Ile His Glu His Ile Leu Ile His Gly Asp 
            420                 425                 430         


Ile Arg Lys Thr Thr Lys Leu Asn Ile Gly Gly Thr Glu Ile Glu Val 
        435                 440                 445             


Glu Thr Leu Val Glu Asp Glu Ala Glu Ala Gly Ala Val Pro Gly Gly 
    450                 455                 460                 


Ser Gly Gly Thr Gly Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val 
465                 470                 475                 480 


Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe 
                485                 490                 495     


Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr 
            500                 505                 510         


Leu Lys Leu Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr 
        515                 520                 525             


Leu Val Thr Thr Leu Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro 
    530                 535                 540                 


Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly 
545                 550                 555                 560 


Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys 
                565                 570                 575     


Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile 
            580                 585                 590         


Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His 
        595                 600                 605             


Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp 
    610                 615                 620                 


Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile 
625                 630                 635                 640 


Glu Asp Gly Gly Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro 
                645                 650                 655     


Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr 
            660                 665                 670         


Gln Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val 
        675                 680                 685             


Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu 
    690                 695                 700                 


Leu Tyr Lys 
705         


<210>  6
<211>  948
<212>  PRT
<213>  artificial

<220>
<223>  inverted transporter polypeptide

<400>  6

Met Ser Ala Thr Ala Ala Thr Val Pro Pro Ala Ala Pro Ala Gly Glu 
1               5                   10                  15      


Gly Gly Pro Pro Ala Pro Pro Pro Asn Leu Thr Ser Asn Arg Arg Leu 
            20                  25                  30          


Gln Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile Met Arg Val 
        35                  40                  45              


Asn Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp 
    50                  55                  60                  


Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser 
65                  70                  75                  80  


Ala Ala Lys Leu Lys Arg Lys Tyr Trp Trp Lys Asn Leu Lys Met Met 
                85                  90                  95      


Ile Ile Leu Gly Val Ile Cys Ala Ile Ile Leu Ile Ile Ile Ile Val 
            100                 105                 110         


Tyr Phe Ser Thr Gly Gly Ser Gly Gly Ser Arg Gly Val Gln Val Glu 
        115                 120                 125             


Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr 
    130                 135                 140                 


Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp 
145                 150                 155                 160 


Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln 
                165                 170                 175     


Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly 
            180                 185                 190         


Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr 
        195                 200                 205             


Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val 
    210                 215                 220                 


Glu Leu Leu Lys Leu Glu Thr Arg Gly Val Gln Val Glu Thr Ile Ser 
225                 230                 235                 240 


Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val 
                245                 250                 255     


His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg 
            260                 265                 270         


Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile 
        275                 280                 285             


Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala 
    290                 295                 300                 


Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro 
305                 310                 315                 320 


Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu 
                325                 330                 335     


Lys Leu Glu Ser Ala Glu Gln Lys Ile Ser Glu Glu Asp Lys Glu Gln 
            340                 345                 350         


Lys Ile Ser Glu Glu Asp Lys Gly Thr Ser Ala Arg Asn Arg Gln Lys 
        355                 360                 365             


Arg Ala Ser Gly Thr Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp 
    370                 375                 380                 


Val Glu Glu Asn Pro Gly Pro Ser Gly Met Asp Tyr Gly Gly Ala Leu 
385                 390                 395                 400 


Ser Ala Val Gly Arg Glu Leu Leu Phe Val Thr Asn Pro Val Val Val 
                405                 410                 415     


Asn Gly Ser Val Leu Val Pro Glu Asp Gln Cys Tyr Cys Ala Gly Trp 
            420                 425                 430         


Ile Glu Ser Arg Gly Thr Asn Gly Ala Gln Thr Ala Ser Asn Val Leu 
        435                 440                 445             


Gln Trp Leu Ala Ala Gly Phe Ser Ile Leu Leu Leu Met Phe Tyr Ala 
    450                 455                 460                 


Tyr Gln Thr Trp Lys Ser Thr Cys Gly Trp Glu Glu Ile Tyr Val Cys 
465                 470                 475                 480 


Ala Ile Glu Met Val Lys Val Ile Leu Glu Phe Phe Phe Glu Phe Lys 
                485                 490                 495     


Asn Pro Ser Met Leu Tyr Leu Ala Thr Gly His Arg Val Gln Trp Leu 
            500                 505                 510         


Arg Tyr Ala Thr Trp Leu Leu Thr Cys Pro Val Ile Leu Ile His Leu 
        515                 520                 525             


Ser Asn Leu Thr Gly Leu Ser Asn Asp Tyr Ser Arg Arg Thr Met Gly 
    530                 535                 540                 


Leu Leu Val Ser Asp Ile Gly Cys Ile Val Trp Gly Ala Thr Ser Ala 
545                 550                 555                 560 


Met Ala Thr Gly Tyr Val Lys Val Ile Phe Phe Cys Leu Gly Leu Cys 
                565                 570                 575     


Tyr Gly Ala Asn Thr Phe Phe His Ala Ala Lys Ala Tyr Ile Glu Gly 
            580                 585                 590         


Tyr His Thr Val Pro Lys Gly Arg Cys Arg Gln Val Val Thr Gly Met 
        595                 600                 605             


Ala Trp Leu Phe Phe Val Ser Trp Gly Met Phe Pro Ile Leu Phe Ile 
    610                 615                 620                 


Leu Gly Pro Glu Gly Phe Gly Val Leu Ser Val Tyr Gly Ser Thr Val 
625                 630                 635                 640 


Gly His Thr Ile Ile Asp Leu Met Ser Lys Asn Cys Trp Gly Leu Leu 
                645                 650                 655     


Gly His Tyr Leu Arg Val Leu Ile His Glu His Ile Leu Ile His Gly 
            660                 665                 670         


Asp Ile Arg Lys Thr Thr Lys Leu Asn Ile Gly Gly Thr Glu Ile Glu 
        675                 680                 685             


Val Glu Thr Leu Val Glu Asp Glu Ala Glu Ala Gly Ala Val Pro Gly 
    690                 695                 700                 


Gly Ser Gly Gly Thr Gly Val Ser Lys Gly Glu Glu Leu Phe Thr Gly 
705                 710                 715                 720 


Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys 
                725                 730                 735     


Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu 
            740                 745                 750         


Thr Leu Lys Leu Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro 
        755                 760                 765             


Thr Leu Val Thr Thr Leu Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr 
    770                 775                 780                 


Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu 
785                 790                 795                 800 


Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr 
                805                 810                 815     


Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg 
            820                 825                 830         


Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly 
        835                 840                 845             


His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Thr Ala 
    850                 855                 860                 


Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn 
865                 870                 875                 880 


Ile Glu Asp Gly Gly Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr 
                885                 890                 895     


Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser 
            900                 905                 910         


Tyr Gln Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met 
        915                 920                 925             


Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp 
    930                 935                 940                 


Glu Leu Tyr Lys 
945             


<210>  7
<211>  774
<212>  PRT
<213>  artificial

<220>
<223>  inverted transporter polypeptide

<400>  7

Met Tyr Gln Arg Met Leu Arg Cys Gly Ala Glu Leu Gly Ser Pro Gly 
1               5                   10                  15      


Gly Gly Ser Ser Gly Gly Ala Gly Gly Arg Leu Ala Leu Leu Trp Ile 
            20                  25                  30          


Val Pro Leu Thr Leu Ser Gly Leu Leu Gly Val Ala Trp Gly Ala Ser 
        35                  40                  45              


Ser Leu Gly Ala His His Ile His His Lys Leu Glu Gln Lys Leu Ile 
    50                  55                  60                  


Ser Glu Glu Asp Leu Gly Gly Leu Ala Asn Pro Thr Arg Val Gly Gly 
65                  70                  75                  80  


Arg Glu Pro Tyr Pro Gly Ser Ala Glu Val Ile Arg Glu Ser Ser Ser 
                85                  90                  95      


Thr Thr Gly Met Val Val Gly Ile Val Ala Ala Ala Ala Leu Cys Ile 
            100                 105                 110         


Leu Ile Leu Leu Tyr Ala Met Lys Lys Arg Arg Ala Lys Gly Gly Ser 
        115                 120                 125             


Gly Gly Ser Gly Gly Leu Glu His Gly Thr Ile Pro Phe Asn Arg Thr 
    130                 135                 140                 


His Arg Ser Lys Arg Ser Ser Gly Met Ser Arg Leu Val Ala Ala Ser 
145                 150                 155                 160 


Trp Leu Leu Ala Leu Leu Leu Cys Gly Ile Thr Ser Thr Thr Thr Ala 
                165                 170                 175     


Ser Ser Ala Pro Ala Ala Ser Ser Thr Asp Gly Thr Ala Ala Ala Ala 
            180                 185                 190         


Val Ser His Tyr Ala Met Asn Gly Phe Asp Glu Leu Ala Lys Gly Ala 
        195                 200                 205             


Val Val Pro Glu Asp His Phe Val Cys Gly Pro Ala Asp Lys Cys Tyr 
    210                 215                 220                 


Cys Ser Ala Trp Leu His Ser Arg Gly Thr Pro Gly Glu Lys Ile Gly 
225                 230                 235                 240 


Ala Gln Val Cys Gln Trp Ile Ala Phe Ser Ile Ala Ile Ala Leu Leu 
                245                 250                 255     


Thr Phe Tyr Gly Phe Ser Ala Trp Lys Ala Thr Cys Gly Trp Glu Glu 
            260                 265                 270         


Val Tyr Val Cys Cys Val Glu Val Leu Phe Val Thr Leu Glu Ile Phe 
        275                 280                 285             


Lys Glu Phe Ser Ser Pro Ala Thr Val Tyr Leu Ser Thr Gly Asn His 
    290                 295                 300                 


Ala Tyr Cys Leu Arg Tyr Phe Glu Trp Leu Leu Ser Cys Pro Val Ile 
305                 310                 315                 320 


Leu Ile Lys Leu Ser Asn Leu Ser Gly Leu Lys Asn Asp Tyr Ser Lys 
                325                 330                 335     


Arg Thr Met Gly Leu Ile Val Ser Cys Val Gly Met Ile Val Phe Gly 
            340                 345                 350         


Met Ala Ala Gly Leu Ala Thr Asp Trp Leu Lys Trp Leu Leu Tyr Ile 
        355                 360                 365             


Val Ser Cys Ile Tyr Gly Gly Tyr Met Tyr Phe Gln Ala Ala Lys Cys 
    370                 375                 380                 


Tyr Val Glu Ala Asn His Ser Val Pro Lys Gly His Cys Arg Met Val 
385                 390                 395                 400 


Val Lys Leu Met Ala Tyr Ala Tyr Phe Ala Ser Trp Gly Ser Tyr Pro 
                405                 410                 415     


Ile Leu Trp Ala Val Gly Pro Glu Gly Leu Leu Lys Leu Ser Pro Tyr 
            420                 425                 430         


Ala Asn Ser Ile Gly His Ser Ile Cys Asp Ile Ile Ala Lys Glu Phe 
        435                 440                 445             


Trp Thr Phe Leu Ala His His Leu Arg Ile Lys Ile His Glu His Ile 
    450                 455                 460                 


Leu Ile His Gly Asp Ile Arg Lys Thr Thr Lys Met Glu Ile Gly Gly 
465                 470                 475                 480 


Glu Glu Val Glu Val Glu Glu Phe Val Glu Glu Glu Asp Glu Asp Thr 
                485                 490                 495     


Val Gly Gly Ser Gly Gly Ser Lys Ser Arg Ile Thr Ser Glu Gly Glu 
            500                 505                 510         


Tyr Ile Pro Leu Asp Gln Ile Asp Ile Asn Gly Gly Ser Gly Gly Thr 
        515                 520                 525             


Gly Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
    530                 535                 540                 


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
545                 550                 555                 560 


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
                565                 570                 575     


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
            580                 585                 590         


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
        595                 600                 605             


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
    610                 615                 620                 


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
625                 630                 635                 640 


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
                645                 650                 655     


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
            660                 665                 670         


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
        675                 680                 685             


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
    690                 695                 700                 


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
705                 710                 715                 720 


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu 
                725                 730                 735     


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
            740                 745                 750         


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Phe 
        755                 760                 765             


Cys Tyr Glu Asn Glu Val 
    770                 


