                         SEQUENCE LISTING

<110>  ImaginAb, Inc.
       Mascioni, Alessandro
       Olafsen , Tove
       Satpayev, Daulet
 
<120>  ANTIGEN BINDING CONSTRUCTS TO CD4

<130>  IGNAB.048WO

<150>  62/682339
<151>  2018-06-08

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAX16H5

<400>  1

Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Gln Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Gln Trp Ile 
        35                  40                  45              


Gly Ala Leu Tyr Pro Gly Asn Val 
    50                  55      


<210>  2
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IAB41

<400>  2

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Leu Tyr Pro Gly Asn Val 
    50                  55      


<210>  3
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAX16H5

<400>  3

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Ala Met Thr Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55              


<210>  4
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IAB41

<400>  4

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Ile Pro 
    50                  55              


<210>  5
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  minibody

<400>  5

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Val Tyr Tyr Cys Gln Gln Trp Ser Asp Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Ser Thr Ser Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gln Val Gln Leu 
        115                 120                 125             


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
    130                 135                 140                 


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asn Tyr Trp Met His Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile Gly Ala Leu Tyr 
                165                 170                 175     


Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln Lys Phe Gln Gly Arg Val 
            180                 185                 190         


Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser 
        195                 200                 205             


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Met Gly 
    210                 215                 220                 


Thr Thr Leu Glu Ala Pro Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        275                 280                 285             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    290                 295                 300                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
305                 310                 315                 320 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                325                 330                 335     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            340                 345                 350         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        355                 360                 365             


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    370                 375         


<210>  6
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  minibody

<400>  6

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Val Tyr Tyr Cys Gln Gln Trp Ser Asp Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Ser Thr Ser Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gln Val Gln Leu 
        115                 120                 125             


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
    130                 135                 140                 


Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asn Tyr Trp Met His Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile Gly Ala Leu Tyr 
                165                 170                 175     


Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln Lys Phe Gln Gly Arg Val 
            180                 185                 190         


Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser 
        195                 200                 205             


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Met Gly 
    210                 215                 220                 


Thr Thr Leu Glu Ala Pro Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Pro Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        275                 280                 285             


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    290                 295                 300                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
305                 310                 315                 320 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                325                 330                 335     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            340                 345                 350         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        355                 360                 365             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    370                 375                 380 


<210>  7
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  minbody

<400>  7

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Leu Tyr Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Met Gly Thr Thr Leu Glu Ala Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Ser Thr Ser Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Ile Val Leu Thr Gln 
    130                 135                 140                 


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
145                 150                 155                 160 


Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu Tyr Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Thr Ser Asn Leu Ala 
            180                 185                 190         


Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Ala Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Asp Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        275                 280                 285             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    290                 295                 300                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
305                 310                 315                 320 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                325                 330                 335     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            340                 345                 350         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        355                 360                 365             


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    370                 375         


<210>  8
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  minibody

<400>  8

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Leu Tyr Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Met Gly Thr Thr Leu Glu Ala Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Ser Thr Ser Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Ile Val Leu Thr Gln 
    130                 135                 140                 


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
145                 150                 155                 160 


Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu Tyr Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Thr Ser Asn Leu Ala 
            180                 185                 190         


Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Ala Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Asp Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Pro Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        275                 280                 285             


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    290                 295                 300                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
305                 310                 315                 320 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                325                 330                 335     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            340                 345                 350         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        355                 360                 365             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    370                 375                 380 


<210>  9
<211>  1194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge

<400>  9

Ala Thr Gly Gly Ala Gly Ala Cys Cys Gly Ala Cys Ala Cys Ala Cys 
1               5                   10                  15      


Thr Gly Cys Thr Gly Cys Thr Gly Thr Gly Gly Gly Thr Gly Cys Thr 
            20                  25                  30          


Gly Cys Thr Gly Cys Thr Gly Thr Gly Gly Gly Thr Gly Cys Cys Cys 
        35                  40                  45              


Gly Gly Ala Ala Gly Cys Ala Cys Cys Gly Gly Ala Gly Ala Ala Ala 
    50                  55                  60                  


Thr Cys Gly Thr Gly Cys Thr Gly Ala Cys Cys Cys Ala Gly Thr Cys 
65                  70                  75                  80  


Cys Cys Cys Thr Gly Cys Thr Ala Cys Cys Cys Thr Gly Ala Gly Cys 
                85                  90                  95      


Cys Thr Gly Ala Gly Cys Cys Cys Thr Gly Gly Cys Gly Ala Ala Ala 
            100                 105                 110         


Gly Gly Gly Cys Cys Ala Cys Ala Cys Thr Gly Thr Cys Cys Thr Gly 
        115                 120                 125             


Cys Thr Cys Cys Gly Cys Cys Ala Gly Gly Ala Gly Cys Ala Gly Cys 
    130                 135                 140                 


Gly Thr Gly Ala Gly Cys Thr Ala Thr Cys Thr Gly Thr Ala Cys Thr 
145                 150                 155                 160 


Gly Gly Thr Ala Cys Cys Ala Gly Cys Ala Gly Ala Ala Gly Cys Cys 
                165                 170                 175     


Cys Gly Gly Ala Cys Ala Gly Gly Cys Cys Cys Cys Thr Ala Gly Gly 
            180                 185                 190         


Cys Thr Gly Cys Thr Gly Ala Thr Cys Thr Ala Cys Gly Ala Cys Ala 
        195                 200                 205             


Cys Cys Ala Gly Cys Ala Ala Cys Cys Thr Gly Gly Cys Cys Ala Gly 
    210                 215                 220                 


Cys Gly Gly Cys Ala Thr Cys Cys Cys Thr Gly Ala Cys Ala Gly Gly 
225                 230                 235                 240 


Thr Thr Cys Thr Cys Cys Gly Gly Cys Thr Cys Cys Gly Gly Cys Ala 
                245                 250                 255     


Gly Cys Gly Gly Cys Ala Cys Ala Gly Ala Thr Thr Thr Cys Ala Cys 
            260                 265                 270         


Cys Cys Thr Gly Ala Cys Cys Ala Thr Cys Thr Cys Cys Ala Gly Ala 
        275                 280                 285             


Cys Thr Gly Gly Ala Gly Cys Cys Cys Gly Ala Ala Gly Ala Cys Gly 
    290                 295                 300                 


Cys Cys Gly Cys Cys Gly Thr Cys Thr Ala Cys Thr Ala Cys Thr Gly 
305                 310                 315                 320 


Cys Cys Ala Gly Cys Ala Gly Thr Gly Gly Ala Gly Cys Gly Ala Thr 
                325                 330                 335     


Thr Ala Thr Cys Cys Thr Cys Thr Gly Ala Cys Cys Thr Thr Cys Gly 
            340                 345                 350         


Gly Cys Gly Gly Cys Gly Gly Cys Ala Cys Cys Ala Ala Gly Cys Thr 
        355                 360                 365             


Cys Gly Ala Gly Ala Thr Cys Ala Ala Gly Gly Gly Cys Ala Gly Cys 
    370                 375                 380                 


Ala Cys Cys Ala Gly Cys Gly Gly Ala Gly Gly Cys Gly Gly Cys Ala 
385                 390                 395                 400 


Gly Cys Gly Gly Cys Gly Gly Cys Gly Gly Cys Ala Gly Cys Gly Gly 
                405                 410                 415     


Cys Gly Gly Ala Gly Gly Ala Gly Gly Cys Ala Gly Cys Ala Gly Cys 
            420                 425                 430         


Cys Ala Ala Gly Thr Gly Cys Ala Gly Cys Thr Gly Gly Thr Gly Cys 
        435                 440                 445             


Ala Gly Ala Gly Cys Gly Gly Cys Gly Cys Cys Gly Ala Gly Gly Thr 
    450                 455                 460                 


Gly Ala Ala Gly Ala Ala Gly Cys Cys Thr Gly Gly Cys Gly Cys Thr 
465                 470                 475                 480 


Ala Gly Cys Gly Thr Gly Ala Ala Gly Gly Thr Gly Thr Cys Cys Thr 
                485                 490                 495     


Gly Thr Ala Ala Gly Gly Cys Thr Thr Cys Cys Gly Gly Cys Thr Ala 
            500                 505                 510         


Cys Ala Gly Cys Thr Thr Cys Gly Cys Cys Ala Ala Cys Thr Ala Cys 
        515                 520                 525             


Thr Gly Gly Ala Thr Gly Cys Ala Cys Thr Gly Gly Gly Thr Cys Ala 
    530                 535                 540                 


Gly Ala Cys Ala Gly Gly Cys Thr Cys Cys Cys Gly Gly Cys Cys Ala 
545                 550                 555                 560 


Gly Ala Gly Gly Cys Thr Gly Gly Ala Ala Thr Gly Gly Ala Thr Cys 
                565                 570                 575     


Gly Gly Cys Gly Cys Cys Cys Thr Gly Thr Ala Cys Cys Cys Cys Gly 
            580                 585                 590         


Gly Cys Ala Ala Cys Gly Thr Gly Gly Ala Thr Ala Cys Cys Ala Cys 
        595                 600                 605             


Cys Thr Ala Cys Ala Ala Cys Cys Ala Gly Ala Ala Gly Thr Thr Cys 
    610                 615                 620                 


Cys Ala Gly Gly Gly Cys Ala Gly Ala Gly Thr Cys Ala Cys Cys Ala 
625                 630                 635                 640 


Thr Thr Ala Cys Cys Ala Gly Gly Gly Ala Cys Ala Cys Ala Ala Gly 
                645                 650                 655     


Cys Gly Cys Cys Ala Gly Cys Ala Cys Cys Gly Cys Thr Thr Ala Thr 
            660                 665                 670         


Ala Thr Gly Gly Ala Gly Cys Thr Gly Thr Cys Cys Thr Cys Cys Cys 
        675                 680                 685             


Thr Cys Ala Gly Gly Ala Gly Cys Gly Ala Gly Gly Ala Cys Ala Cys 
    690                 695                 700                 


Cys Gly Cys Cys Gly Thr Cys Thr Ala Thr Thr Ala Cys Thr Gly Cys 
705                 710                 715                 720 


Ala Cys Cys Ala Gly Gly Ala Thr Gly Gly Gly Cys Ala Cys Cys Ala 
                725                 730                 735     


Cys Ala Cys Thr Gly Gly Ala Gly Gly Cys Thr Cys Cys Thr Cys Thr 
            740                 745                 750         


Gly Gly Ala Cys Thr Ala Thr Thr Gly Gly Gly Gly Cys Cys Ala Gly 
        755                 760                 765             


Gly Gly Cys Ala Cys Ala Cys Thr Gly Gly Thr Gly Ala Cys Ala Gly 
    770                 775                 780                 


Thr Gly Thr Cys Cys Thr Cys Cys Gly Ala Gly Cys Cys Cys Ala Ala 
785                 790                 795                 800 


Ala Ala Gly Cys Ala Gly Cys Gly Ala Thr Ala Ala Gly Ala Cys Cys 
                805                 810                 815     


Cys Ala Cys Ala Cys Cys Thr Gly Cys Cys Cys Thr Cys Cys Thr Thr 
            820                 825                 830         


Gly Cys Cys Cys Thr Cys Cys Thr Thr Gly Thr Gly Gly Cys Gly Gly 
        835                 840                 845             


Ala Gly Gly Ala Thr Cys Cys Ala Gly Cys Gly Gly Ala Gly Gly Ala 
    850                 855                 860                 


Gly Gly Ala Ala Gly Cys Gly Gly Ala Gly Gly Cys Cys Ala Ala Cys 
865                 870                 875                 880 


Cys Cys Ala Gly Gly Gly Ala Ala Cys Cys Thr Cys Ala Gly Gly Thr 
                885                 890                 895     


Gly Thr Ala Cys Ala Cys Ala Cys Thr Cys Cys Cys Cys Cys Cys Cys 
            900                 905                 910         


Ala Gly Cys Ala Gly Gly Gly Ala Gly Gly Ala Gly Ala Thr Gly Ala 
        915                 920                 925             


Cys Cys Ala Ala Gly Ala Ala Cys Cys Ala Gly Gly Thr Gly Ala Gly 
    930                 935                 940                 


Cys Cys Thr Gly Ala Cys Cys Thr Gly Cys Cys Thr Cys Gly Thr Gly 
945                 950                 955                 960 


Ala Ala Ala Gly Gly Cys Thr Thr Cys Thr Ala Cys Cys Cys Cys Ala 
                965                 970                 975     


Gly Cys Gly Ala Cys Ala Thr Cys Gly Cys Cys Gly Thr Gly Gly Ala 
            980                 985                 990         


Gly Thr Gly Gly Gly Ala Gly Ala  Gly Cys Ala Ala Cys  Gly Gly Cys 
        995                 1000                 1005             


Cys Ala  Ala Cys Cys Cys Gly  Ala Ala Ala Ala Cys  Ala Ala Cys 
    1010                 1015                 1020             


Thr Ala  Cys Ala Ala Ala Ala  Cys Cys Ala Cys Cys  Cys Cys Cys 
    1025                 1030                 1035             


Cys Cys  Thr Gly Thr Cys Cys  Thr Gly Gly Ala Cys  Ala Gly Cys 
    1040                 1045                 1050             


Gly Ala  Thr Gly Gly Cys Ala  Gly Cys Thr Thr Cys  Thr Thr Cys 
    1055                 1060                 1065             


Cys Thr  Cys Thr Ala Cys Ala  Gly Cys Ala Ala Gly  Cys Thr Gly 
    1070                 1075                 1080             


Ala Cys  Cys Gly Thr Gly Gly  Ala Cys Ala Ala Gly  Ala Gly Cys 
    1085                 1090                 1095             


Ala Gly  Ala Thr Gly Gly Cys  Ala Gly Cys Ala Gly  Gly Gly Cys 
    1100                 1105                 1110             


Ala Ala  Cys Gly Thr Gly Thr  Thr Cys Thr Cys Cys  Thr Gly Thr 
    1115                 1120                 1125             


Thr Cys  Cys Gly Thr Gly Ala  Thr Gly Cys Ala Cys  Gly Ala Gly 
    1130                 1135                 1140             


Gly Cys  Cys Cys Thr Cys Cys  Ala Cys Ala Ala Cys  Cys Ala Cys 
    1145                 1150                 1155             


Thr Ala  Cys Ala Cys Cys Cys  Ala Gly Ala Ala Ala  Thr Cys Cys 
    1160                 1165                 1170             


Cys Thr  Gly Thr Cys Cys Cys  Thr Gly Thr Cys Cys  Cys Cys Cys 
    1175                 1180                 1185             


Gly Gly  Cys Thr Gly Ala 
    1190                 


<210>  10
<211>  1194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge

<400>  10

Ala Thr Gly Gly Ala Gly Ala Cys Cys Gly Ala Thr Ala Cys Cys Cys 
1               5                   10                  15      


Thr Cys Cys Thr Gly Cys Thr Cys Thr Gly Gly Gly Thr Gly Cys Thr 
            20                  25                  30          


Gly Cys Thr Gly Cys Thr Gly Thr Gly Gly Gly Thr Gly Cys Cys Thr 
        35                  40                  45              


Gly Gly Ala Ala Gly Cys Ala Cys Ala Gly Gly Cys Cys Ala Gly Gly 
    50                  55                  60                  


Thr Gly Cys Ala Gly Cys Thr Gly Gly Thr Gly Cys Ala Gly Ala Gly 
65                  70                  75                  80  


Cys Gly Gly Ala Gly Cys Cys Gly Ala Gly Gly Thr Gly Ala Ala Ala 
                85                  90                  95      


Ala Ala Ala Cys Cys Cys Gly Gly Cys Gly Cys Cys Thr Cys Cys Gly 
            100                 105                 110         


Thr Gly Ala Ala Gly Gly Thr Gly Ala Gly Cys Thr Gly Cys Ala Ala 
        115                 120                 125             


Gly Gly Cys Cys Ala Gly Cys Gly Gly Cys Thr Ala Cys Ala Gly Cys 
    130                 135                 140                 


Thr Thr Cys Gly Cys Cys Ala Ala Cys Thr Ala Cys Thr Gly Gly Ala 
145                 150                 155                 160 


Thr Gly Cys Ala Cys Thr Gly Gly Gly Thr Gly Ala Gly Gly Cys Ala 
                165                 170                 175     


Gly Gly Cys Cys Cys Cys Thr Gly Gly Cys Cys Ala Gly Ala Gly Gly 
            180                 185                 190         


Cys Thr Gly Gly Ala Ala Thr Gly Gly Ala Thr Thr Gly Gly Cys Gly 
        195                 200                 205             


Cys Cys Cys Thr Gly Thr Ala Cys Cys Cys Thr Gly Gly Cys Ala Ala 
    210                 215                 220                 


Cys Gly Thr Gly Gly Ala Cys Ala Cys Cys Ala Cys Cys Thr Ala Cys 
225                 230                 235                 240 


Ala Ala Cys Cys Ala Gly Ala Ala Ala Thr Thr Cys Cys Ala Gly Gly 
                245                 250                 255     


Gly Cys Ala Gly Gly Gly Thr Gly Ala Cys Cys Ala Thr Cys Ala Cys 
            260                 265                 270         


Cys Ala Gly Ala Gly Ala Thr Ala Cys Cys Ala Gly Cys Gly Cys Cys 
        275                 280                 285             


Ala Gly Cys Ala Cys Cys Gly Cys Thr Thr Ala Cys Ala Thr Gly Gly 
    290                 295                 300                 


Ala Ala Cys Thr Gly Ala Gly Cys Ala Gly Cys Cys Thr Gly Ala Gly 
305                 310                 315                 320 


Gly Ala Gly Cys Gly Ala Gly Gly Ala Thr Ala Cys Cys Gly Cys Cys 
                325                 330                 335     


Gly Thr Gly Thr Ala Cys Thr Ala Cys Thr Gly Cys Ala Cys Cys Ala 
            340                 345                 350         


Gly Gly Ala Thr Gly Gly Gly Cys Ala Cys Ala Ala Cys Cys Cys Thr 
        355                 360                 365             


Gly Gly Ala Gly Gly Cys Thr Cys Cys Cys Cys Thr Gly Gly Ala Thr 
    370                 375                 380                 


Thr Ala Cys Thr Gly Gly Gly Gly Cys Cys Ala Gly Gly Gly Cys Ala 
385                 390                 395                 400 


Cys Ala Cys Thr Gly Gly Thr Gly Ala Cys Ala Gly Thr Cys Ala Gly 
                405                 410                 415     


Cys Ala Gly Cys Gly Gly Cys Ala Gly Cys Ala Cys Ala Ala Gly Cys 
            420                 425                 430         


Gly Gly Ala Gly Gly Ala Gly Gly Ala Ala Gly Cys Gly Gly Ala Gly 
        435                 440                 445             


Gly Ala Gly Gly Cys Ala Gly Cys Gly Gly Cys Gly Gly Ala Gly Gly 
    450                 455                 460                 


Ala Gly Gly Ala Ala Gly Cys Ala Gly Cys Gly Ala Gly Ala Thr Cys 
465                 470                 475                 480 


Gly Thr Gly Cys Thr Gly Ala Cys Cys Cys Ala Gly Thr Cys Cys Cys 
                485                 490                 495     


Cys Cys Gly Cys Thr Ala Cys Ala Cys Thr Gly Ala Gly Cys Cys Thr 
            500                 505                 510         


Gly Ala Gly Cys Cys Cys Thr Gly Gly Cys Gly Ala Gly Ala Gly Ala 
        515                 520                 525             


Gly Cys Cys Ala Cys Cys Cys Thr Gly Thr Cys Cys Thr Gly Cys Thr 
    530                 535                 540                 


Cys Cys Gly Cys Cys Ala Gly Ala Ala Gly Cys Thr Cys Cys Gly Thr 
545                 550                 555                 560 


Gly Ala Gly Cys Thr Ala Cys Cys Thr Gly Thr Ala Cys Thr Gly Gly 
                565                 570                 575     


Thr Ala Cys Cys Ala Gly Cys Ala Gly Ala Ala Ala Cys Cys Thr Gly 
            580                 585                 590         


Gly Cys Cys Ala Gly Gly Cys Cys Cys Cys Cys Ala Gly Gly Cys Thr 
        595                 600                 605             


Gly Cys Thr Gly Ala Thr Cys Thr Ala Thr Gly Ala Cys Ala Cys Cys 
    610                 615                 620                 


Ala Gly Cys Ala Ala Cys Cys Thr Gly Gly Cys Cys Thr Cys Cys Gly 
625                 630                 635                 640 


Gly Cys Ala Thr Thr Cys Cys Cys Gly Ala Cys Ala Gly Gly Thr Thr 
                645                 650                 655     


Cys Ala Gly Cys Gly Gly Cys Ala Gly Cys Gly Gly Ala Thr Cys Cys 
            660                 665                 670         


Gly Gly Ala Ala Cys Cys Gly Ala Cys Thr Thr Cys Ala Cys Cys Cys 
        675                 680                 685             


Thr Gly Ala Cys Cys Ala Thr Cys Thr Cys Cys Ala Gly Ala Cys Thr 
    690                 695                 700                 


Cys Gly Ala Gly Cys Cys Cys Gly Ala Gly Gly Ala Thr Gly Cys Cys 
705                 710                 715                 720 


Gly Cys Cys Gly Thr Gly Thr Ala Thr Thr Ala Cys Thr Gly Cys Cys 
                725                 730                 735     


Ala Gly Cys Ala Ala Thr Gly Gly Ala Gly Cys Gly Ala Thr Thr Ala 
            740                 745                 750         


Thr Cys Cys Thr Cys Thr Gly Ala Cys Cys Thr Thr Thr Gly Gly Cys 
        755                 760                 765             


Gly Gly Ala Gly Gly Cys Ala Cys Cys Ala Ala Gly Cys Thr Cys Gly 
    770                 775                 780                 


Ala Gly Ala Thr Cys Ala Ala Gly Gly Ala Gly Cys Cys Cys Ala Ala 
785                 790                 795                 800 


Ala Thr Cys Cys Thr Cys Cys Gly Ala Thr Ala Ala Ala Ala Cys Cys 
                805                 810                 815     


Cys Ala Cys Ala Cys Cys Thr Gly Cys Cys Cys Thr Cys Cys Thr Thr 
            820                 825                 830         


Gly Thr Cys Cys Thr Cys Cys Thr Thr Gly Thr Gly Gly Cys Gly Gly 
        835                 840                 845             


Cys Gly Gly Cys Thr Cys Cys Ala Gly Cys Gly Gly Ala Gly Gly Cys 
    850                 855                 860                 


Gly Gly Cys Thr Cys Cys Gly Gly Cys Gly Gly Ala Cys Ala Gly Cys 
865                 870                 875                 880 


Cys Cys Ala Gly Ala Gly Ala Gly Cys Cys Thr Cys Ala Gly Gly Thr 
                885                 890                 895     


Cys Thr Ala Cys Ala Cys Cys Cys Thr Gly Cys Cys Cys Cys Cys Thr 
            900                 905                 910         


Ala Gly Cys Ala Gly Gly Gly Ala Ala Gly Ala Gly Ala Thr Gly Ala 
        915                 920                 925             


Cys Cys Ala Ala Gly Ala Ala Cys Cys Ala Gly Gly Thr Gly Ala Gly 
    930                 935                 940                 


Cys Cys Thr Gly Ala Cys Cys Thr Gly Thr Cys Thr Gly Gly Thr Gly 
945                 950                 955                 960 


Ala Ala Gly Gly Gly Cys Thr Thr Cys Thr Ala Cys Cys Cys Cys Thr 
                965                 970                 975     


Cys Cys Gly Ala Thr Ala Thr Thr Gly Cys Cys Gly Thr Cys Gly Ala 
            980                 985                 990         


Gly Thr Gly Gly Gly Ala Gly Thr  Cys Cys Ala Ala Cys  Gly Gly Cys 
        995                 1000                 1005             


Cys Ala  Gly Cys Cys Cys Gly  Ala Ala Ala Ala Cys  Ala Ala Cys 
    1010                 1015                 1020             


Thr Ala  Cys Ala Ala Ala Ala  Cys Ala Ala Cys Cys  Cys Cys Cys 
    1025                 1030                 1035             


Cys Cys  Cys Gly Thr Gly Cys  Thr Cys Gly Ala Cys  Thr Cys Cys 
    1040                 1045                 1050             


Gly Ala  Cys Gly Gly Thr Thr  Cys Thr Thr Thr Thr  Thr Thr Cys 
    1055                 1060                 1065             


Cys Thr  Cys Thr Ala Cys Thr  Cys Cys Ala Ala Gly  Cys Thr Gly 
    1070                 1075                 1080             


Ala Cys  Cys Gly Thr Cys Gly  Ala Cys Ala Ala Gly  Thr Cys Cys 
    1085                 1090                 1095             


Ala Gly  Gly Thr Gly Gly Cys  Ala Gly Cys Ala Gly  Gly Gly Cys 
    1100                 1105                 1110             


Ala Ala  Cys Gly Thr Gly Thr  Thr Cys Ala Gly Cys  Thr Gly Cys 
    1115                 1120                 1125             


Ala Gly  Cys Gly Thr Gly Ala  Thr Gly Cys Ala Cys  Gly Ala Gly 
    1130                 1135                 1140             


Gly Cys  Cys Cys Thr Cys Cys  Ala Cys Ala Ala Cys  Cys Ala Cys 
    1145                 1150                 1155             


Thr Ala  Cys Ala Cys Cys Cys  Ala Gly Ala Ala Ala  Thr Cys Cys 
    1160                 1165                 1170             


Cys Thr  Cys Thr Cys Cys Cys  Thr Gly Ala Gly Cys  Cys Cys Cys 
    1175                 1180                 1185             


Gly Gly  Cys Thr Gly Ala 
    1190                 


<210>  11
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cys-Diabody

<400>  11

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Val Tyr Tyr Cys Gln Gln Trp Ser Asp Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Gln 
            100                 105                 110         


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
        115                 120                 125             


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asn Tyr Trp 
    130                 135                 140                 


Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile Gly 
145                 150                 155                 160 


Ala Leu Tyr Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln Lys Phe Gln 
                165                 170                 175     


Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr Met 
            180                 185                 190         


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
        195                 200                 205             


Arg Met Gly Thr Thr Leu Glu Ala Pro Leu Asp Tyr Trp Gly Gln Gly 
    210                 215                 220                 


Thr Leu Val Thr Val Ser Ser Gly Gly Cys 
225                 230                 


<210>  12
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cys-diabody

<400>  12

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Val Tyr Tyr Cys Gln Gln Trp Ser Asp Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Gln 
            100                 105                 110         


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
        115                 120                 125             


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asn Tyr Trp 
    130                 135                 140                 


Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile Gly 
145                 150                 155                 160 


Ala Leu Tyr Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln Lys Phe Gln 
                165                 170                 175     


Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr Met 
            180                 185                 190         


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
        195                 200                 205             


Arg Met Gly Thr Thr Leu Glu Ala Pro Leu Asp Tyr Trp Gly Gln Gly 
    210                 215                 220                 


Thr Leu Val Thr Val Ser Ser Gly Gly Cys Pro Pro Cys 
225                 230                 235         


<210>  13
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cys-diabody

<400>  13

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Val Tyr Tyr Cys Gln Gln Trp Ser Asp Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Gln 
            100                 105                 110         


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
        115                 120                 125             


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asn Tyr Trp 
    130                 135                 140                 


Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile Gly 
145                 150                 155                 160 


Ala Leu Tyr Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln Lys Phe Gln 
                165                 170                 175     


Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr Met 
            180                 185                 190         


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
        195                 200                 205             


Arg Met Gly Thr Thr Leu Glu Ala Pro Leu Asp Tyr Trp Gly Gln Gly 
    210                 215                 220                 


Thr Leu Val Thr Val Ser Ser Gly Gly Cys Pro Pro Cys Pro Pro Cys 
225                 230                 235                 240 


<210>  14
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cys-diabody

<400>  14

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Val Tyr Tyr Cys Gln Gln Trp Ser Asp Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ser Gly Gly Gly Gly Gln 
            100                 105                 110         


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
        115                 120                 125             


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asn Tyr Trp 
    130                 135                 140                 


Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile Gly 
145                 150                 155                 160 


Ala Leu Tyr Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln Lys Phe Gln 
                165                 170                 175     


Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr Met 
            180                 185                 190         


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
        195                 200                 205             


Arg Met Gly Thr Thr Leu Glu Ala Pro Leu Asp Tyr Trp Gly Gln Gly 
    210                 215                 220                 


Thr Leu Val Thr Val Ser Ser Gly Gly Cys Pro Pro Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Pro Cys 
            


<210>  15
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cys-diabody

<400>  15

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Leu Tyr Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Met Gly Thr Thr Leu Glu Ala Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly Glu Ile Val 
        115                 120                 125             


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
    130                 135                 140                 


Thr Leu Ser Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu Tyr Trp Tyr 
145                 150                 155                 160 


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Thr Ser 
                165                 170                 175     


Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
            180                 185                 190         


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Ala Ala 
        195                 200                 205             


Val Tyr Tyr Cys Gln Gln Trp Ser Asp Tyr Pro Leu Thr Phe Gly Gly 
    210                 215                 220                 


Gly Thr Lys Leu Glu Ile Lys Gly Gly Cys 
225                 230                 


<210>  16
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cys-diabody

<400>  16

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Leu Tyr Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Met Gly Thr Thr Leu Glu Ala Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly Glu Ile Val 
        115                 120                 125             


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
    130                 135                 140                 


Thr Leu Ser Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu Tyr Trp Tyr 
145                 150                 155                 160 


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Thr Ser 
                165                 170                 175     


Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
            180                 185                 190         


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Ala Ala 
        195                 200                 205             


Val Tyr Tyr Cys Gln Gln Trp Ser Asp Tyr Pro Leu Thr Phe Gly Gly 
    210                 215                 220                 


Gly Thr Lys Leu Glu Ile Lys Gly Gly Cys Pro Pro Cys 
225                 230                 235         


<210>  17
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cys-diabody

<400>  17

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Leu Tyr Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Met Gly Thr Thr Leu Glu Ala Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly Glu Ile Val 
        115                 120                 125             


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
    130                 135                 140                 


Thr Leu Ser Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu Tyr Trp Tyr 
145                 150                 155                 160 


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Thr Ser 
                165                 170                 175     


Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
            180                 185                 190         


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Ala Ala 
        195                 200                 205             


Val Tyr Tyr Cys Gln Gln Trp Ser Asp Tyr Pro Leu Thr Phe Gly Gly 
    210                 215                 220                 


Gly Thr Lys Leu Glu Ile Lys Gly Gly Cys Pro Pro Cys Pro Pro Cys 
225                 230                 235                 240 


<210>  18
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cys-diabody

<400>  18

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Leu Tyr Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Met Gly Thr Thr Leu Glu Ala Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly Glu Ile Val 
        115                 120                 125             


Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala 
    130                 135                 140                 


Thr Leu Ser Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu Tyr Trp Tyr 
145                 150                 155                 160 


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Thr Ser 
                165                 170                 175     


Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
            180                 185                 190         


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Ala Ala 
        195                 200                 205             


Val Tyr Tyr Cys Gln Gln Trp Ser Asp Tyr Pro Leu Thr Phe Gly Gly 
    210                 215                 220                 


Gly Thr Lys Leu Glu Ile Lys Gly Gly Cys Pro Pro Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Pro Cys 
            


<210>  19

<400>  19
000

<210>  20

<400>  20
000

<210>  21

<400>  21
000

<210>  22
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide

<400>  22

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  23
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide

<400>  23

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  24
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide

<400>  24

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  25
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide

<400>  25

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  26
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide

<400>  26

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  27
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide

<400>  27

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  28
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide

<400>  28

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  29
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide

<400>  29

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  30
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide

<400>  30

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  31
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide

<400>  31

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  32
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide

<400>  32

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  33
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide

<400>  33

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  34
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge

<400>  34

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Pro 
1               5                   10                  15      


Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly 
            20                  25              


<210>  35
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge

<400>  35

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Pro 
1               5                   10                  15      


Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly 
            20                  25                  30      


<210>  36
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge

<400>  36

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Pro 
1               5                   10                  15      


Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly 
            20                  25              


<210>  37
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge

<400>  37

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Pro 
1               5                   10                  15      


Cys Pro Pro Cys Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Gly 
            20                  25                  30      


<210>  38
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAX16H5

<400>  38

Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Gln Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Gln Trp Ile 
        35                  40                  45              


Gly Ala Leu Tyr Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln 
    50                  55                  60          


<210>  39
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  39

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln 
    50                  55                  60          


<210>  40
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IAB41

<400>  40

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Leu Tyr Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln 
    50                  55                  60          


<210>  41
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAX16H5

<400>  41

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Ala Met Thr Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg 
    50                  55                  60  


<210>  42
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  42

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Trp Tyr Gln Gln Lys Pro Gly Leu Ala 
            20                  25                  30          


Pro Arg Leu Leu Ile Tyr Gly Ile Pro Asp Arg 
        35                  40              


<210>  43
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IAB41

<400>  43

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg 
    50                  55                  60  


<210>  44
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  44

Lys Lys Val Val Leu Gly Lys Lys Gly Asp Thr Val Glu Leu Thr Cys 
1               5                   10                  15      


Thr Ala Ser Gln Lys Lys Ser Ile Gln Phe His Trp Lys Asn Ser Asn 
            20                  25                  30          


Gln Ile Lys Ile Leu Gly Asn Gln Gly Ser Phe Leu Thr Lys Gly Pro 
        35                  40                  45              


Ser Lys Leu Asn Asp Arg Ala Asp Ser Arg Arg Ser Leu Trp Asp Gln 
    50                  55                  60                  


Gly Asn Phe Pro Leu Ile Ile Lys Asn Leu Lys Ile Glu Asp Ser Asp 
65                  70                  75                  80  


Thr Tyr Ile Cys Glu Val Glu Asp Gln Lys Glu Glu Val Gln Leu Leu 
                85                  90                  95      


Val Phe Gly Leu Thr Ala Asn Ser Asp Thr His Leu Leu Gln Gly Gln 
            100                 105                 110         


Ser Leu Thr Leu Thr Leu Glu Ser Pro Pro Gly Ser Ser Pro Ser Val 
        115                 120                 125             


Gln Cys Arg Ser Pro Arg Gly Lys Asn Ile Gln Gly Gly Lys Thr Leu 
    130                 135                 140                 


Ser Val Ser Gln Leu Glu Leu Gln Asp Ser Gly Thr Trp Thr Cys Thr 
145                 150                 155                 160 


Val Leu Gln Asn Gln Lys Lys Val Glu Phe Lys Ile Asp Ile Val Val 
                165                 170                 175     


Leu Ala Phe Gln Lys Ala Ser Ser Ile Val Tyr Lys Lys Glu Gly Glu 
            180                 185                 190         


Gln Val Glu Phe Ser Phe Pro Leu Ala Phe Thr Val Glu Lys Leu Thr 
        195                 200                 205             


Gly Ser Gly Glu Leu Trp Trp Gln Ala Glu Arg Ala Ser Ser Ser Lys 
    210                 215                 220                 


Ser Trp Ile Thr Phe Asp Leu Lys Asn Lys Glu Val Ser Val Lys Arg 
225                 230                 235                 240 


Val Thr Gln Asp Pro Lys Leu Gln Met Gly Lys Lys Leu Pro Leu His 
                245                 250                 255     


Leu Thr Leu Pro Gln Ala Leu Pro Gln Tyr Ala Gly Ser Gly Asn Leu 
            260                 265                 270         


Thr Leu Ala Leu Glu Ala Lys Thr Gly Lys Leu His Gln Glu Val Asn 
        275                 280                 285             


Leu Val Val Met Arg Ala Thr Gln Leu Gln Lys Asn Leu Thr Cys Glu 
    290                 295                 300                 


Val Trp Gly Pro Thr Ser Pro Lys Leu Met Leu Ser Leu Lys Leu Glu 
305                 310                 315                 320 


Asn Lys Glu Ala Lys Val Ser Lys Arg Glu Lys Ala Val Trp Val Leu 
                325                 330                 335     


Asn Pro Glu Ala Gly Met Trp Gln Cys Leu Leu Ser Asp Ser Gly Gln 
            340                 345                 350         


Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr Trp Ser Thr Pro 
        355                 360                 365             


Val Gln Pro Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu 
    370                 375                 380                 


Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg 
385                 390                 395                 400 


Arg Arg Gln Ala Glu Arg Met Ser Gln Ile Lys Arg Leu Leu Ser Glu 
                405                 410                 415     


Lys Lys Thr Cys Gln Cys Pro His Arg Phe Gln Lys Thr Cys Ser Pro 
            420                 425                 430         


Ile 
    


