                               SEQUENCE LISTING

<110> TUFTS MEDICAL CENTER, INC.
      AUTTX, LLC
 
<120> TARGETED TREATMENT OF AUTISM SPECTRUM DISORDER AND OTHER 
      NEUROLOGICAL OR PSYCHIATRIC DISORDERS

<130> 052991-501001WO

<140> PCT/US2019/035655
<141> 2019-06-05

<150> 62/681,086
<151> 2018-06-05

<160> 978   

<170> PatentIn version 3.5

<210> 1

<400> 1
000


<210> 2

<400> 2
000


<210> 3

<400> 3
000


<210> 4

<400> 4
000


<210> 5

<400> 5
000


<210> 6

<400> 6
000


<210> 7

<400> 7
000


<210> 8

<400> 8
000


<210> 9

<400> 9
000


<210> 10

<400> 10
000


<210> 11

<400> 11
000


<210> 12

<400> 12
000


<210> 13

<400> 13
000


<210> 14

<400> 14
000


<210> 15

<400> 15
000


<210> 16

<400> 16
000


<210> 17

<400> 17
000


<210> 18

<400> 18
000


<210> 19

<400> 19
000


<210> 20

<400> 20
000


<210> 21

<400> 21
000


<210> 22

<400> 22
000


<210> 23

<400> 23
000


<210> 24

<400> 24
000


<210> 25

<400> 25
000


<210> 26

<400> 26
000


<210> 27

<400> 27
000


<210> 28

<400> 28
000


<210> 29

<400> 29
000


<210> 30

<400> 30
000


<210> 31

<400> 31
000


<210> 32

<400> 32
000


<210> 33

<400> 33
000


<210> 34

<400> 34
000


<210> 35

<400> 35
000


<210> 36

<400> 36
000


<210> 37

<400> 37
000


<210> 38

<400> 38
000


<210> 39

<400> 39
000


<210> 40

<400> 40
000


<210> 41

<400> 41
000


<210> 42

<400> 42
000


<210> 43

<400> 43
000


<210> 44

<400> 44
000


<210> 45

<400> 45
000


<210> 46

<400> 46
000


<210> 47

<400> 47
000


<210> 48

<400> 48
000


<210> 49

<400> 49
000


<210> 50

<400> 50
000


<210> 51

<400> 51
000


<210> 52

<400> 52
000


<210> 53

<400> 53
000


<210> 54

<400> 54
000


<210> 55

<400> 55
000


<210> 56

<400> 56
000


<210> 57

<400> 57
000


<210> 58

<400> 58
000


<210> 59

<400> 59
000


<210> 60

<400> 60
000


<210> 61

<400> 61
000


<210> 62

<400> 62
000


<210> 63

<400> 63
000


<210> 64

<400> 64
000


<210> 65

<400> 65
000


<210> 66

<400> 66
000


<210> 67

<400> 67
000


<210> 68

<400> 68
000


<210> 69

<400> 69
000


<210> 70

<400> 70
000


<210> 71

<400> 71
000


<210> 72

<400> 72
000


<210> 73

<400> 73
000


<210> 74

<400> 74
000


<210> 75

<400> 75
000


<210> 76

<400> 76
000


<210> 77

<400> 77
000


<210> 78

<400> 78
000


<210> 79

<400> 79
000


<210> 80

<400> 80
000


<210> 81

<400> 81
000


<210> 82

<400> 82
000


<210> 83

<400> 83
000


<210> 84

<400> 84
000


<210> 85

<400> 85
000


<210> 86

<400> 86
000


<210> 87

<400> 87
000


<210> 88

<400> 88
000


<210> 89

<400> 89
000


<210> 90

<400> 90
000


<210> 91

<400> 91
000


<210> 92

<400> 92
000


<210> 93

<400> 93
000


<210> 94

<400> 94
000


<210> 95

<400> 95
000


<210> 96

<400> 96
000


<210> 97

<400> 97
000


<210> 98
<211> 2221
<212> PRT
<213> Homo sapiens

<400> 98
Met Val Asn Glu Asn Thr Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Thr Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Thr Ile Ser Thr Val Ser Ser Thr Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Thr Thr 
                85                  90                  95      


Ala Thr Arg Pro Pro Arg Ala Leu Leu Cys Leu Thr Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Thr Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Thr Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Thr Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Thr Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Thr 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Thr Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Thr Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Thr Leu Thr Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Thr Glu Val Gln Asp Thr Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Thr Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr Ile Leu Val Glu Thr 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Thr Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Thr Arg Arg Ser Thr 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Thr Val Phe Gln Ile Leu Thr 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Thr Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Thr Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Thr Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Thr Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Thr Thr Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Thr Ile Phe Thr Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Thr Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Thr Thr Ile Phe 
    930                 935                 940                 


Thr Ile Glu Ile Ala Leu Lys Ile Leu Gly Asn Ala Asp Tyr Val Phe 
945                 950                 955                 960 


Thr Ser Ile Phe Thr Leu Glu Ile Ile Leu Lys Met Thr Ala Tyr Gly 
                965                 970                 975     


Ala Phe Leu His Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu 
            980                 985                 990         


Asp Leu Leu Val Val Ser Val Ser  Leu Ile Ser Phe Gly  Ile Gln Ser 
        995                 1000                 1005             


Ser Ala  Ile Asn Val Val Lys  Ile Leu Arg Val Leu  Arg Val Leu 
    1010                 1015                 1020             


Arg Pro  Leu Arg Ala Ile Asn  Arg Ala Lys Gly Leu  Lys His Val 
    1025                 1030                 1035             


Val Gln  Cys Val Phe Val Ala  Ile Arg Thr Ile Gly  Asn Ile Val 
    1040                 1045                 1050             


Ile Val  Thr Thr Leu Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val 
    1055                 1060                 1065             


Gln Leu  Phe Lys Gly Lys Leu  Tyr Thr Cys Ser Asp  Ser Ser Lys 
    1070                 1075                 1080             


Gln Thr  Glu Ala Glu Cys Lys  Gly Asn Tyr Ile Thr  Tyr Lys Asp 
    1085                 1090                 1095             


Gly Glu  Val Asp His Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn 
    1100                 1105                 1110             


Ser Lys  Phe Asp Phe Asp Asn  Val Leu Ala Ala Met  Met Ala Leu 
    1115                 1120                 1125             


Phe Thr  Val Ser Thr Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg 
    1130                 1135                 1140             


Ser Ile  Asp Ser His Thr Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr 
    1145                 1150                 1155             


Arg Val  Glu Ile Ser Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile 
    1160                 1165                 1170             


Ala Phe  Phe Met Met Asn Ile  Phe Val Gly Phe Val  Ile Val Thr 
    1175                 1180                 1185             


Phe Gln  Glu Gln Gly Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp 
    1190                 1195                 1200             


Lys Asn  Gln Arg Gln Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro 
    1205                 1210                 1215             


Leu Arg  Arg Tyr Ile Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp 
    1220                 1225                 1230             


Tyr Val  Val Asn Ser Thr Tyr  Phe Glu Tyr Leu Met  Phe Val Leu 
    1235                 1240                 1245             


Ile Leu  Leu Asn Thr Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln 
    1250                 1255                 1260             


Ser Cys  Leu Phe Lys Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe 
    1265                 1270                 1275             


Thr Gly  Leu Phe Thr Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe 
    1280                 1285                 1290             


Lys Pro  Lys Gly Tyr Phe Ser  Asp Pro Trp Asn Val  Phe Asp Phe 
    1295                 1300                 1305             


Leu Ile  Val Ile Gly Ser Ile  Ile Asp Val Ile Leu  Ser Glu Thr 
    1310                 1315                 1320             


Asn His  Tyr Phe Cys Asp Ala  Trp Asn Thr Phe Asp  Ala Leu Ile 
    1325                 1330                 1335             


Val Val  Gly Ser Ile Val Asp  Ile Ala Ile Thr Glu  Val Asn Pro 
    1340                 1345                 1350             


Ala Glu  His Thr Gln Cys Ser  Pro Ser Met Asn Ala  Glu Glu Asn 
    1355                 1360                 1365             


Ser Arg  Ile Ser Ile Thr Phe  Phe Arg Leu Phe Arg  Val Met Arg 
    1370                 1375                 1380             


Leu Val  Lys Leu Leu Ser Arg  Gly Glu Gly Ile Arg  Thr Leu Leu 
    1385                 1390                 1395             


Trp Thr  Phe Ile Lys Ser Phe  Gln Ala Leu Pro Tyr  Val Ala Leu 
    1400                 1405                 1410             


Leu Ile  Val Met Leu Phe Phe  Ile Tyr Ala Val Ile  Gly Met Gln 
    1415                 1420                 1425             


Val Phe  Gly Lys Ile Ala Leu  Asn Asp Thr Thr Glu  Ile Asn Arg 
    1430                 1435                 1440             


Asn Asn  Asn Phe Gln Thr Phe  Pro Gln Ala Val Leu  Leu Leu Phe 
    1445                 1450                 1455             


Arg Cys  Ala Thr Gly Glu Ala  Trp Gln Asp Ile Met  Leu Ala Cys 
    1460                 1465                 1470             


Met Pro  Gly Lys Lys Cys Ala  Pro Glu Ser Glu Pro  Ser Asn Ser 
    1475                 1480                 1485             


Thr Glu  Gly Glu Thr Pro Cys  Gly Ser Ser Phe Ala  Val Phe Tyr 
    1490                 1495                 1500             


Phe Ile  Ser Phe Tyr Met Leu  Cys Ala Phe Leu Ile  Ile Asn Leu 
    1505                 1510                 1515             


Phe Val  Ala Val Ile Met Asp  Asn Phe Asp Tyr Leu  Thr Arg Asp 
    1520                 1525                 1530             


Trp Ser  Ile Leu Gly Pro His  His Leu Asp Glu Phe  Lys Arg Ile 
    1535                 1540                 1545             


Trp Ala  Glu Tyr Asp Pro Glu  Ala Lys Gly Arg Ile  Lys His Leu 
    1550                 1555                 1560             


Asp Val  Val Thr Leu Leu Arg  Arg Ile Gln Pro Pro  Leu Gly Phe 
    1565                 1570                 1575             


Gly Lys  Leu Cys Pro His Arg  Val Ala Cys Lys Arg  Leu Val Ser 
    1580                 1585                 1590             


Met Asn  Met Pro Leu Asn Ser  Asp Gly Thr Val Met  Phe Asn Ala 
    1595                 1600                 1605             


Thr Leu  Phe Ala Leu Val Arg  Thr Ala Leu Arg Ile  Lys Thr Glu 
    1610                 1615                 1620             


Gly Asn  Leu Glu Gln Ala Asn  Glu Glu Leu Arg Ala  Ile Ile Lys 
    1625                 1630                 1635             


Lys Ile  Trp Lys Arg Thr Ser  Met Lys Leu Leu Asp  Gln Val Val 
    1640                 1645                 1650             


Pro Pro  Ala Gly Asp Asp Glu  Val Thr Val Gly Lys  Phe Tyr Ala 
    1655                 1660                 1665             


Thr Phe  Leu Ile Gln Glu Tyr  Phe Arg Lys Phe Lys  Lys Arg Lys 
    1670                 1675                 1680             


Glu Gln  Gly Leu Val Gly Lys  Pro Ser Gln Arg Asn  Ala Leu Ser 
    1685                 1690                 1695             


Leu Gln  Ala Gly Leu Arg Thr  Leu His Asp Ile Gly  Pro Glu Ile 
    1700                 1705                 1710             


Arg Arg  Ala Ile Ser Gly Asp  Leu Thr Ala Glu Glu  Glu Leu Asp 
    1715                 1720                 1725             


Lys Ala  Met Lys Glu Ala Val  Ser Ala Ala Ser Glu  Asp Asp Ile 
    1730                 1735                 1740             


Phe Arg  Arg Ala Gly Gly Leu  Phe Gly Asn His Val  Ser Tyr Tyr 
    1745                 1750                 1755             


Gln Ser  Asp Gly Arg Ser Ala  Phe Pro Gln Thr Phe  Thr Thr Gln 
    1760                 1765                 1770             


Arg Pro  Leu His Ile Asn Lys  Ala Gly Ser Ser Gln  Gly Asp Thr 
    1775                 1780                 1785             


Glu Ser  Pro Ser His Glu Lys  Leu Val Asp Ser Thr  Phe Thr Pro 
    1790                 1795                 1800             


Ser Ser  Tyr Ser Ser Thr Gly  Ser Asn Ala Asn Ile  Asn Asn Ala 
    1805                 1810                 1815             


Asn Asn  Thr Ala Leu Gly Arg  Leu Pro Arg Pro Ala  Gly Tyr Pro 
    1820                 1825                 1830             


Ser Thr  Val Ser Thr Val Glu  Gly His Gly Pro Pro  Leu Ser Pro 
    1835                 1840                 1845             


Ala Ile  Arg Val Gln Glu Val  Ala Trp Lys Leu Ser  Ser Asn Arg 
    1850                 1855                 1860             


Glu Arg  His Val Pro Met Cys  Glu Asp Leu Glu Leu  Arg Arg Asp 
    1865                 1870                 1875             


Ser Gly  Ser Ala Gly Thr Gln  Ala His Cys Leu Leu  Leu Arg Arg 
    1880                 1885                 1890             


Ala Asn  Pro Ser Arg Cys His  Ser Arg Glu Ser Gln  Ala Ala Met 
    1895                 1900                 1905             


Ala Gly  Gln Glu Glu Thr Ser  Gln Asp Glu Thr Tyr  Glu Val Lys 
    1910                 1915                 1920             


Met Asn  His Asp Thr Glu Ala  Cys Ser Glu Pro Ser  Leu Leu Ser 
    1925                 1930                 1935             


Thr Glu  Met Leu Ser Tyr Gln  Asp Asp Glu Asn Arg  Gln Leu Thr 
    1940                 1945                 1950             


Leu Pro  Glu Glu Asp Lys Arg  Asp Ile Arg Gln Ser  Pro Lys Arg 
    1955                 1960                 1965             


Gly Phe  Leu Arg Ser Ala Ser  Leu Gly Arg Arg Ala  Ser Phe His 
    1970                 1975                 1980             


Leu Glu  Cys Leu Lys Arg Gln  Lys Asp Arg Gly Gly  Asp Ile Ser 
    1985                 1990                 1995             


Gln Lys  Thr Val Leu Pro Leu  His Leu Val His His  Gln Ala Leu 
    2000                 2005                 2010             


Ala Val  Ala Gly Leu Ser Pro  Leu Leu Gln Arg Ser  His Ser Pro 
    2015                 2020                 2025             


Ala Ser  Phe Pro Arg Pro Phe  Ala Thr Pro Pro Ala  Thr Pro Gly 
    2030                 2035                 2040             


Ser Arg  Gly Trp Pro Pro Gln  Pro Val Pro Thr Leu  Arg Leu Glu 
    2045                 2050                 2055             


Gly Val  Glu Ser Ser Glu Lys  Leu Asn Ser Ser Phe  Pro Ser Ile 
    2060                 2065                 2070             


His Cys  Gly Ser Trp Ala Glu  Thr Thr Pro Gly Gly  Gly Gly Ser 
    2075                 2080                 2085             


Ser Ala  Ala Arg Arg Val Arg  Pro Val Ser Leu Met  Val Pro Ser 
    2090                 2095                 2100             


Gln Ala  Gly Ala Pro Gly Arg  Gln Phe His Gly Ser  Ala Ser Ser 
    2105                 2110                 2115             


Leu Val  Glu Ala Val Leu Ile  Ser Glu Gly Leu Gly  Gln Phe Ala 
    2120                 2125                 2130             


Gln Asp  Pro Lys Phe Ile Glu  Val Thr Thr Gln Glu  Leu Ala Asp 
    2135                 2140                 2145             


Ala Cys  Asp Met Thr Ile Glu  Glu Met Glu Ser Ala  Ala Asp Asn 
    2150                 2155                 2160             


Ile Leu  Ser Gly Gly Ala Pro  Gln Ser Pro Asn Gly  Ala Leu Leu 
    2165                 2170                 2175             


Pro Phe  Val Asn Cys Arg Asp  Ala Gly Gln Asp Arg  Ala Gly Gly 
    2180                 2185                 2190             


Glu Glu  Asp Ala Gly Cys Val  Arg Ala Arg Gly Arg  Pro Ser Glu 
    2195                 2200                 2205             


Glu Glu  Leu Gln Asp Ser Arg  Val Tyr Val Ser Ser  Leu 
    2210                 2215                 2220     


<210> 99

<400> 99
000


<210> 100

<400> 100
000


<210> 101

<400> 101
000


<210> 102

<400> 102
000


<210> 103

<400> 103
000


<210> 104

<400> 104
000


<210> 105

<400> 105
000


<210> 106

<400> 106
000


<210> 107

<400> 107
000


<210> 108

<400> 108
000


<210> 109
<211> 1300
<212> PRT
<213> Homo sapiens

<400> 109
Met Leu Asp Pro Ser Ser Ser Glu Glu Glu Ser Asp Glu Gly Leu Glu 
1               5                   10                  15      


Glu Glu Ser Arg Asp Val Leu Val Ala Ala Gly Ser Ser Gln Arg Ala 
            20                  25                  30          


Pro Pro Ala Pro Thr Arg Glu Gly Arg Arg Asp Ala Pro Gly Arg Ala 
        35                  40                  45              


Gly Gly Gly Gly Ala Ala Arg Ser Val Ser Pro Ser Pro Ser Val Leu 
    50                  55                  60                  


Ser Glu Gly Arg Asp Glu Pro Gln Arg Gln Leu Asp Asp Glu Gln Glu 
65                  70                  75                  80  


Arg Arg Ile Arg Leu Gln Leu Tyr Val Phe Val Val Arg Cys Ile Ala 
                85                  90                  95      


Tyr Pro Phe Asn Ala Lys Gln Pro Thr Asp Met Ala Arg Arg Gln Gln 
            100                 105                 110         


Lys Leu Asn Lys Gln Gln Leu Gln Leu Leu Lys Glu Arg Phe Gln Ala 
        115                 120                 125             


Phe Leu Asn Gly Glu Thr Gln Ile Val Ala Asp Glu Ala Phe Cys Asn 
    130                 135                 140                 


Ala Val Arg Ser Tyr Tyr Glu Val Phe Leu Lys Ser Asp Arg Val Ala 
145                 150                 155                 160 


Arg Met Val Gln Ser Gly Gly Cys Ser Ala Asn Asp Phe Arg Glu Val 
                165                 170                 175     


Phe Lys Lys Asn Ile Glu Lys Arg Val Arg Ser Leu Pro Glu Ile Asp 
            180                 185                 190         


Gly Leu Ser Lys Glu Thr Val Leu Ser Ser Trp Ile Ala Lys Tyr Asp 
        195                 200                 205             


Ala Ile Tyr Arg Gly Glu Glu Asp Leu Cys Lys Gln Pro Asn Arg Met 
    210                 215                 220                 


Ala Leu Ser Ala Val Ser Glu Leu Ile Leu Ser Lys Glu Gln Leu Tyr 
225                 230                 235                 240 


Glu Met Phe Gln Gln Ile Leu Gly Ile Lys Lys Leu Glu His Gln Leu 
                245                 250                 255     


Leu Tyr Asn Ala Cys Gln Leu Asp Asn Ala Asp Glu Gln Ala Ala Gln 
            260                 265                 270         


Ile Arg Arg Glu Leu Asp Gly Arg Leu Gln Leu Ala Asp Lys Met Ala 
        275                 280                 285             


Lys Glu Arg Lys Phe Pro Lys Phe Ile Ala Lys Asp Met Glu Asn Met 
    290                 295                 300                 


Tyr Ile Glu Glu Leu Arg Ser Ser Val Asn Leu Leu Met Ala Asn Leu 
305                 310                 315                 320 


Glu Ser Leu Pro Val Ser Lys Gly Gly Pro Glu Phe Lys Leu Gln Lys 
                325                 330                 335     


Leu Lys Arg Ser Gln Asn Ser Ala Phe Leu Asp Ile Gly Asp Glu Asn 
            340                 345                 350         


Glu Ile Gln Leu Ser Lys Ser Asp Val Val Leu Ser Phe Thr Leu Glu 
        355                 360                 365             


Ile Val Ile Met Glu Val Gln Gly Leu Lys Ser Val Ala Pro Asn Arg 
    370                 375                 380                 


Ile Val Tyr Cys Thr Met Glu Val Glu Gly Glu Lys Leu Gln Thr Asp 
385                 390                 395                 400 


Gln Ala Glu Ala Ser Arg Pro Gln Trp Gly Thr Gln Gly Asp Phe Thr 
                405                 410                 415     


Thr Thr His Pro Arg Pro Val Val Lys Val Lys Leu Phe Thr Glu Ser 
            420                 425                 430         


Thr Gly Val Leu Ala Leu Glu Asp Lys Glu Leu Gly Arg Val Ile Leu 
        435                 440                 445             


Tyr Pro Thr Ser Asn Ser Ser Lys Ser Ala Glu Leu His Arg Met Val 
    450                 455                 460                 


Val Pro Lys Asn Ser Gln Asp Ser Asp Leu Lys Ile Lys Leu Ala Val 
465                 470                 475                 480 


Arg Met Asp Lys Pro Ala His Met Lys His Ser Gly Tyr Leu Tyr Ala 
                485                 490                 495     


Leu Gly Gln Lys Val Trp Lys Arg Trp Lys Lys Arg Tyr Phe Val Leu 
            500                 505                 510         


Val Gln Val Ser Gln Tyr Thr Phe Ala Met Cys Ser Tyr Arg Glu Lys 
        515                 520                 525             


Lys Ser Glu Pro Gln Glu Leu Met Gln Leu Glu Gly Tyr Thr Val Asp 
    530                 535                 540                 


Tyr Thr Asp Pro His Pro Gly Leu Gln Gly Gly Cys Met Phe Phe Asn 
545                 550                 555                 560 


Ala Val Lys Glu Gly Asp Thr Val Ile Phe Ala Ser Asp Asp Glu Gln 
                565                 570                 575     


Asp Arg Ile Leu Trp Val Gln Ala Met Tyr Arg Ala Thr Gly Gln Ser 
            580                 585                 590         


Tyr Lys Pro Val Pro Ala Ile Gln Thr Gln Lys Leu Asn Pro Lys Gly 
        595                 600                 605             


Gly Thr Leu His Ala Asp Ala Gln Leu Ser Gly Lys Asp Ala Asp Arg 
    610                 615                 620                 


Phe Gln Lys His Gly Met Asp Glu Phe Ile Ser Ala Asn Pro Cys Lys 
625                 630                 635                 640 


Leu Asp His Ala Phe Leu Phe Arg Ile Leu Gln Arg Gln Thr Leu Asp 
                645                 650                 655     


His Arg Leu Asn Asp Ser Tyr Ser Cys Leu Gly Trp Phe Ser Pro Gly 
            660                 665                 670         


Gln Val Phe Val Leu Asp Glu Tyr Cys Ala Arg Tyr Gly Val Arg Gly 
        675                 680                 685             


Cys His Arg His Leu Cys Tyr Leu Ala Glu Leu Met Glu His Ser Glu 
    690                 695                 700                 


Asn Gly Ala Val Ile Asp Pro Thr Leu Leu His Tyr Ser Phe Ala Phe 
705                 710                 715                 720 


Cys Ala Ser His Val His Gly Asn Arg Pro Asp Gly Ile Gly Thr Val 
                725                 730                 735     


Ser Val Glu Glu Lys Glu Arg Phe Glu Glu Ile Lys Glu Arg Leu Ser 
            740                 745                 750         


Ser Leu Leu Glu Asn Gln Ile Ser His Phe Arg Tyr Cys Phe Pro Phe 
        755                 760                 765             


Gly Arg Pro Glu Gly Ala Leu Lys Ala Thr Leu Ser Leu Leu Glu Arg 
    770                 775                 780                 


Val Leu Met Lys Asp Ile Ala Thr Pro Ile Pro Ala Glu Glu Val Lys 
785                 790                 795                 800 


Lys Val Val Arg Lys Cys Leu Glu Lys Ala Ala Leu Ile Asn Tyr Thr 
                805                 810                 815     


Arg Leu Thr Glu Tyr Ala Lys Ile Glu Gly Pro Ala Glu Lys Glu Thr 
            820                 825                 830         


Glu Thr Met Asn Gln Ala Ser Pro Ala Arg Lys Leu Glu Glu Ile Leu 
        835                 840                 845             


His Leu Ala Glu Leu Cys Ile Glu Val Leu Gln Gln Asn Glu Glu His 
    850                 855                 860                 


His Ala Glu Ala Phe Ala Trp Trp Pro Asp Leu Leu Ala Glu His Ala 
865                 870                 875                 880 


Glu Lys Phe Trp Ala Leu Phe Thr Val Asp Met Asp Thr Ala Leu Glu 
                885                 890                 895     


Ala Gln Pro Gln Asp Ser Trp Asp Ser Phe Pro Leu Phe Gln Leu Leu 
            900                 905                 910         


Asn Asn Phe Leu Arg Asn Asp Thr Leu Leu Cys Asn Gly Lys Phe His 
        915                 920                 925             


Lys His Leu Gln Glu Ile Phe Val Pro Leu Val Val Arg Tyr Val Asp 
    930                 935                 940                 


Leu Met Glu Ser Ser Ile Ala Gln Ser Ile His Arg Gly Phe Glu Gln 
945                 950                 955                 960 


Glu Thr Trp Gln Pro Val Lys Asn Ile Ala Asn Ser Leu Pro Asn Val 
                965                 970                 975     


Ala Leu Pro Lys Val Pro Ser Leu Pro Leu Asn Leu Pro Gln Ile Pro 
            980                 985                 990         


Asn Ile Ser Thr Ala Ser Trp Met  Pro Ser Leu Tyr Glu  Ser Thr Asn 
        995                 1000                 1005             


Gly Ser  Ala Thr Ser Glu Asp  Leu Phe Trp Lys Leu  Asp Ala Leu 
    1010                 1015                 1020             


Gln Met  Phe Val Phe Asp Leu  His Trp Pro Glu Gln  Glu Phe Ala 
    1025                 1030                 1035             


His His  Leu Glu Gln Arg Leu  Lys Leu Met Ala Ser  Asp Met Leu 
    1040                 1045                 1050             


Glu Ala  Cys Val Lys Arg Thr  Arg Thr Ala Phe Glu  Leu Lys Leu 
    1055                 1060                 1065             


Gln Lys  Ala Ser Lys Thr Thr  Asp Leu Arg Ile Pro  Ala Ser Val 
    1070                 1075                 1080             


Cys Thr  Met Phe Asn Val Leu  Val Asp Ala Lys Lys  Gln Ser Thr 
    1085                 1090                 1095             


Lys Leu  Cys Ala Leu Asp Gly  Gly Gln Glu Gln Gln  Tyr His Ser 
    1100                 1105                 1110             


Lys Ile  Asp Asp Leu Ile Asp  Asn Ser Val Lys Glu  Ile Ile Ser 
    1115                 1120                 1125             


Leu Leu  Val Ser Lys Phe Val  Ser Val Leu Glu Gly  Val Leu Ser 
    1130                 1135                 1140             


Lys Leu  Ser Arg Tyr Asp Glu  Gly Thr Phe Phe Ser  Ser Ile Leu 
    1145                 1150                 1155             


Ser Phe  Thr Val Lys Ala Ala  Ala Lys Tyr Val Asp  Val Pro Lys 
    1160                 1165                 1170             


Pro Gly  Met Asp Leu Ala Asp  Thr Tyr Ile Met Phe  Val Arg Gln 
    1175                 1180                 1185             


Asn Gln  Asp Ile Leu Arg Glu  Lys Val Asn Glu Glu  Met Tyr Ile 
    1190                 1195                 1200             


Glu Lys  Leu Phe Asp Gln Trp  Tyr Ser Ser Ser Met  Lys Val Ile 
    1205                 1210                 1215             


Cys Val  Trp Leu Thr Asp Arg  Leu Asp Leu Gln Leu  His Ile Tyr 
    1220                 1225                 1230             


Gln Leu  Lys Thr Leu Ile Lys  Ile Val Lys Lys Thr  Tyr Arg Asp 
    1235                 1240                 1245             


Phe Arg  Leu Gln Gly Val Leu  Glu Gly Thr Leu Asn  Ser Lys Thr 
    1250                 1255                 1260             


Tyr Asp  Thr Val His Arg Arg  Leu Thr Val Glu Glu  Ala Thr Ala 
    1265                 1270                 1275             


Ser Val  Ser Glu Gly Gly Gly  Leu Gln Gly Ile Thr  Met Lys Asp 
    1280                 1285                 1290             


Ser Asp  Glu Glu Glu Glu Gly  
    1295                 1300 


<210> 110

<400> 110
000


<210> 111

<400> 111
000


<210> 112

<400> 112
000


<210> 113

<400> 113
000


<210> 114

<400> 114
000


<210> 115

<400> 115
000


<210> 116

<400> 116
000


<210> 117

<400> 117
000


<210> 118

<400> 118
000


<210> 119

<400> 119
000


<210> 120

<400> 120
000


<210> 121

<400> 121
000


<210> 122

<400> 122
000


<210> 123

<400> 123
000


<210> 124

<400> 124
000


<210> 125

<400> 125
000


<210> 126

<400> 126
000


<210> 127

<400> 127
000


<210> 128

<400> 128
000


<210> 129

<400> 129
000


<210> 130

<400> 130
000


<210> 131

<400> 131
000


<210> 132

<400> 132
000


<210> 133

<400> 133
000


<210> 134

<400> 134
000


<210> 135

<400> 135
000


<210> 136

<400> 136
000


<210> 137

<400> 137
000


<210> 138

<400> 138
000


<210> 139

<400> 139
000


<210> 140

<400> 140
000


<210> 141

<400> 141
000


<210> 142

<400> 142
000


<210> 143

<400> 143
000


<210> 144

<400> 144
000


<210> 145

<400> 145
000


<210> 146

<400> 146
000


<210> 147

<400> 147
000


<210> 148

<400> 148
000


<210> 149

<400> 149
000


<210> 150

<400> 150
000


<210> 151

<400> 151
000


<210> 152

<400> 152
000


<210> 153

<400> 153
000


<210> 154

<400> 154
000


<210> 155

<400> 155
000


<210> 156

<400> 156
000


<210> 157

<400> 157
000


<210> 158

<400> 158
000


<210> 159

<400> 159
000


<210> 160

<400> 160
000


<210> 161

<400> 161
000


<210> 162

<400> 162
000


<210> 163

<400> 163
000


<210> 164

<400> 164
000


<210> 165

<400> 165
000


<210> 166

<400> 166
000


<210> 167

<400> 167
000


<210> 168

<400> 168
000


<210> 169

<400> 169
000


<210> 170

<400> 170
000


<210> 171

<400> 171
000


<210> 172

<400> 172
000


<210> 173

<400> 173
000


<210> 174

<400> 174
000


<210> 175

<400> 175
000


<210> 176

<400> 176
000


<210> 177

<400> 177
000


<210> 178

<400> 178
000


<210> 179

<400> 179
000


<210> 180

<400> 180
000


<210> 181

<400> 181
000


<210> 182

<400> 182
000


<210> 183

<400> 183
000


<210> 184

<400> 184
000


<210> 185

<400> 185
000


<210> 186

<400> 186
000


<210> 187

<400> 187
000


<210> 188

<400> 188
000


<210> 189

<400> 189
000


<210> 190

<400> 190
000


<210> 191

<400> 191
000


<210> 192

<400> 192
000


<210> 193

<400> 193
000


<210> 194

<400> 194
000


<210> 195

<400> 195
000


<210> 196

<400> 196
000


<210> 197

<400> 197
000


<210> 198

<400> 198
000


<210> 199

<400> 199
000


<210> 200

<400> 200
000


<210> 201

<400> 201
000


<210> 202

<400> 202
000


<210> 203

<400> 203
000


<210> 204

<400> 204
000


<210> 205

<400> 205
000


<210> 206

<400> 206
000


<210> 207

<400> 207
000


<210> 208

<400> 208
000


<210> 209

<400> 209
000


<210> 210

<400> 210
000


<210> 211

<400> 211
000


<210> 212

<400> 212
000


<210> 213

<400> 213
000


<210> 214

<400> 214
000


<210> 215

<400> 215
000


<210> 216

<400> 216
000


<210> 217

<400> 217
000


<210> 218

<400> 218
000


<210> 219

<400> 219
000


<210> 220

<400> 220
000


<210> 221

<400> 221
000


<210> 222

<400> 222
000


<210> 223

<400> 223
000


<210> 224

<400> 224
000


<210> 225

<400> 225
000


<210> 226

<400> 226
000


<210> 227

<400> 227
000


<210> 228

<400> 228
000


<210> 229

<400> 229
000


<210> 230

<400> 230
000


<210> 231

<400> 231
000


<210> 232

<400> 232
000


<210> 233

<400> 233
000


<210> 234

<400> 234
000


<210> 235

<400> 235
000


<210> 236

<400> 236
000


<210> 237

<400> 237
000


<210> 238

<400> 238
000


<210> 239

<400> 239
000


<210> 240

<400> 240
000


<210> 241

<400> 241
000


<210> 242

<400> 242
000


<210> 243

<400> 243
000


<210> 244

<400> 244
000


<210> 245

<400> 245
000


<210> 246

<400> 246
000


<210> 247

<400> 247
000


<210> 248

<400> 248
000


<210> 249

<400> 249
000


<210> 250

<400> 250
000


<210> 251

<400> 251
000


<210> 252

<400> 252
000


<210> 253

<400> 253
000


<210> 254

<400> 254
000


<210> 255

<400> 255
000


<210> 256

<400> 256
000


<210> 257

<400> 257
000


<210> 258

<400> 258
000


<210> 259

<400> 259
000


<210> 260

<400> 260
000


<210> 261

<400> 261
000


<210> 262

<400> 262
000


<210> 263

<400> 263
000


<210> 264
<211> 248
<212> PRT
<213> Homo sapiens

<400> 264
Met Ala Thr Val Glu Pro Glu Thr Thr Pro Thr Pro Asn Pro Pro Thr 
1               5                   10                  15      


Thr Glu Glu Glu Lys Thr Glu Ser Asn Gln Glu Val Ala Asn Pro Glu 
            20                  25                  30          


His Tyr Ile Lys His Pro Leu Gln Asn Arg Trp Ala Leu Trp Phe Phe 
        35                  40                  45              


Lys Asn Asp Lys Ser Lys Thr Trp Gln Ala Asn Leu Arg Leu Ile Ser 
    50                  55                  60                  


Lys Phe Asp Thr Val Glu Asp Phe Trp Ala Leu Tyr Asn His Ile Gln 
65                  70                  75                  80  


Leu Ser Ser Asn Leu Met Pro Gly Cys Asp Tyr Ser Leu Phe Lys Asp 
                85                  90                  95      


Gly Ile Glu Pro Met Trp Glu Asp Glu Lys Asn Lys Arg Gly Gly Arg 
            100                 105                 110         


Trp Leu Ile Thr Leu Asn Lys Gln Gln Arg Arg Ser Asp Leu Asp Arg 
        115                 120                 125             


Phe Trp Leu Glu Thr Arg Trp Asp Leu Ala Met Leu Pro Arg Leu Val 
    130                 135                 140                 


Ser Asn Phe Trp Pro Gln Val Ile Leu Pro Leu Gln Pro Pro Lys Val 
145                 150                 155                 160 


Leu Glu Leu Gln Leu Leu Cys Leu Ile Gly Glu Ser Phe Asp Asp Tyr 
                165                 170                 175     


Ser Asp Asp Val Cys Gly Ala Val Val Asn Val Arg Ala Lys Gly Asp 
            180                 185                 190         


Lys Ile Ala Ile Trp Thr Thr Glu Cys Glu Asn Arg Glu Ala Val Thr 
        195                 200                 205             


His Ile Gly Arg Val Tyr Lys Glu Arg Leu Gly Leu Pro Pro Lys Ile 
    210                 215                 220                 


Val Ile Gly Tyr Gln Ser His Ala Asp Thr Ala Thr Lys Ser Gly Ser 
225                 230                 235                 240 


Thr Thr Lys Asn Arg Phe Val Val 
                245             


<210> 265

<400> 265
000


<210> 266

<400> 266
000


<210> 267

<400> 267
000


<210> 268

<400> 268
000


<210> 269

<400> 269
000


<210> 270

<400> 270
000


<210> 271

<400> 271
000


<210> 272

<400> 272
000


<210> 273

<400> 273
000


<210> 274

<400> 274
000


<210> 275

<400> 275
000


<210> 276

<400> 276
000


<210> 277

<400> 277
000


<210> 278

<400> 278
000


<210> 279

<400> 279
000


<210> 280

<400> 280
000


<210> 281

<400> 281
000


<210> 282

<400> 282
000


<210> 283

<400> 283
000


<210> 284

<400> 284
000


<210> 285

<400> 285
000


<210> 286

<400> 286
000


<210> 287

<400> 287
000


<210> 288

<400> 288
000


<210> 289

<400> 289
000


<210> 290

<400> 290
000


<210> 291

<400> 291
000


<210> 292

<400> 292
000


<210> 293

<400> 293
000


<210> 294

<400> 294
000


<210> 295

<400> 295
000


<210> 296

<400> 296
000


<210> 297

<400> 297
000


<210> 298

<400> 298
000


<210> 299

<400> 299
000


<210> 300

<400> 300
000


<210> 301

<400> 301
000


<210> 302

<400> 302
000


<210> 303

<400> 303
000


<210> 304

<400> 304
000


<210> 305

<400> 305
000


<210> 306

<400> 306
000


<210> 307

<400> 307
000


<210> 308

<400> 308
000


<210> 309

<400> 309
000


<210> 310

<400> 310
000


<210> 311

<400> 311
000


<210> 312
<211> 632
<212> PRT
<213> Homo sapiens

<400> 312
Met Glu Glu Leu Val Val Glu Val Arg Gly Ser Asn Gly Ala Phe Tyr 
1               5                   10                  15      


Lys Ala Phe Val Lys Asp Val His Glu Asp Ser Ile Thr Val Ala Phe 
            20                  25                  30          


Glu Asn Asn Trp Gln Pro Asp Arg Gln Ile Pro Phe His Asp Val Arg 
        35                  40                  45              


Phe Pro Pro Pro Val Gly Tyr Asn Lys Asp Ile Asn Glu Ser Asp Glu 
    50                  55                  60                  


Val Glu Val Tyr Ser Arg Ala Asn Glu Lys Glu Pro Cys Cys Trp Trp 
65                  70                  75                  80  


Leu Ala Lys Val Arg Met Ile Lys Gly Glu Phe Tyr Val Ile Glu Tyr 
                85                  90                  95      


Ala Ala Cys Asp Ala Thr Tyr Asn Glu Ile Val Thr Ile Glu Arg Leu 
            100                 105                 110         


Arg Ser Val Asn Pro Asn Lys Pro Ala Thr Lys Asp Thr Phe His Lys 
        115                 120                 125             


Ile Lys Leu Asp Val Pro Glu Asp Leu Arg Gln Met Cys Ala Lys Glu 
    130                 135                 140                 


Ala Ala His Lys Asp Phe Lys Lys Ala Val Gly Ala Phe Ser Val Thr 
145                 150                 155                 160 


Tyr Asp Pro Glu Asn Tyr Gln Leu Val Ile Leu Ser Ile Asn Glu Val 
                165                 170                 175     


Thr Ser Lys Arg Ala His Met Leu Ile Asp Met His Phe Arg Ser Leu 
            180                 185                 190         


Arg Thr Lys Leu Ser Leu Ile Met Arg Asn Glu Glu Ala Ser Lys Gln 
        195                 200                 205             


Leu Glu Ser Ser Arg Gln Leu Ala Ser Arg Phe His Glu Gln Phe Ile 
    210                 215                 220                 


Val Arg Glu Asp Leu Met Gly Leu Ala Ile Gly Thr His Gly Ala Asn 
225                 230                 235                 240 


Ile Gln Gln Ala Arg Lys Val Pro Gly Val Thr Ala Ile Asp Leu Asp 
                245                 250                 255     


Glu Asp Thr Cys Thr Phe His Ile Tyr Gly Glu Asp Gln Asp Ala Val 
            260                 265                 270         


Lys Lys Ala Arg Ser Phe Leu Glu Phe Ala Glu Asp Val Ile Gln Val 
        275                 280                 285             


Pro Arg Asn Leu Val Gly Lys Val Ile Gly Lys Asn Gly Lys Leu Ile 
    290                 295                 300                 


Gln Glu Ile Val Asp Lys Ser Gly Val Val Arg Val Arg Ile Glu Ala 
305                 310                 315                 320 


Glu Asn Glu Lys Asn Val Pro Gln Glu Glu Glu Ile Met Pro Pro Asn 
                325                 330                 335     


Ser Leu Pro Ser Asn Asn Ser Arg Val Gly Pro Asn Ala Pro Glu Glu 
            340                 345                 350         


Lys Lys His Leu Asp Ile Lys Glu Asn Ser Thr His Phe Ser Gln Pro 
        355                 360                 365             


Asn Ser Thr Lys Val Gln Arg Val Leu Val Ala Ser Ser Val Val Ala 
    370                 375                 380                 


Gly Glu Ser Gln Lys Pro Glu Leu Lys Ala Trp Gln Gly Met Val Pro 
385                 390                 395                 400 


Phe Val Phe Val Gly Thr Lys Asp Ser Ile Ala Asn Ala Thr Val Leu 
                405                 410                 415     


Leu Asp Tyr His Leu Asn Tyr Leu Lys Glu Val Asp Gln Leu Arg Leu 
            420                 425                 430         


Glu Arg Leu Gln Ile Asp Glu Gln Leu Arg Gln Ile Gly Ala Ser Ser 
        435                 440                 445             


Arg Pro Pro Pro Asn Arg Thr Asp Lys Glu Lys Ser Tyr Val Thr Asp 
    450                 455                 460                 


Asp Gly Gln Gly Met Gly Arg Gly Ser Arg Pro Tyr Arg Asn Arg Gly 
465                 470                 475                 480 


His Gly Arg Arg Gly Pro Gly Tyr Thr Ser Gly Thr Asn Ser Glu Ala 
                485                 490                 495     


Ser Asn Ala Ser Glu Thr Glu Ser Asp His Arg Asp Glu Leu Ser Asp 
            500                 505                 510         


Trp Ser Leu Ala Pro Thr Glu Glu Glu Arg Glu Ser Phe Leu Arg Arg 
        515                 520                 525             


Gly Asp Gly Arg Arg Arg Gly Gly Gly Gly Arg Gly Gln Gly Gly Arg 
    530                 535                 540                 


Gly Arg Gly Gly Gly Phe Lys Gly Asn Asp Asp His Ser Arg Thr Asp 
545                 550                 555                 560 


Asn Arg Pro Arg Asn Pro Arg Glu Ala Lys Gly Arg Thr Thr Asp Gly 
                565                 570                 575     


Ser Leu Gln Ile Arg Val Asp Cys Asn Asn Glu Arg Ser Val His Thr 
            580                 585                 590         


Lys Thr Leu Gln Asn Thr Ser Ser Glu Gly Ser Arg Leu Arg Thr Gly 
        595                 600                 605             


Lys Asp Arg Asn Gln Lys Lys Glu Lys Pro Asp Ser Val Asp Gly Gln 
    610                 615                 620                 


Gln Pro Leu Val Asn Gly Val Pro 
625                 630         


<210> 313

<400> 313
000


<210> 314

<400> 314
000


<210> 315

<400> 315
000


<210> 316

<400> 316
000


<210> 317

<400> 317
000


<210> 318

<400> 318
000


<210> 319

<400> 319
000


<210> 320

<400> 320
000


<210> 321

<400> 321
000


<210> 322

<400> 322
000


<210> 323

<400> 323
000


<210> 324

<400> 324
000


<210> 325

<400> 325
000


<210> 326

<400> 326
000


<210> 327

<400> 327
000


<210> 328

<400> 328
000


<210> 329

<400> 329
000


<210> 330

<400> 330
000


<210> 331

<400> 331
000


<210> 332

<400> 332
000


<210> 333

<400> 333
000


<210> 334

<400> 334
000


<210> 335

<400> 335
000


<210> 336

<400> 336
000


<210> 337

<400> 337
000


<210> 338

<400> 338
000


<210> 339

<400> 339
000


<210> 340

<400> 340
000


<210> 341

<400> 341
000


<210> 342

<400> 342
000


<210> 343

<400> 343
000


<210> 344

<400> 344
000


<210> 345

<400> 345
000


<210> 346

<400> 346
000


<210> 347

<400> 347
000


<210> 348

<400> 348
000


<210> 349

<400> 349
000


<210> 350

<400> 350
000


<210> 351

<400> 351
000


<210> 352

<400> 352
000


<210> 353

<400> 353
000


<210> 354

<400> 354
000


<210> 355

<400> 355
000


<210> 356

<400> 356
000


<210> 357

<400> 357
000


<210> 358
<211> 943
<212> PRT
<213> Homo sapiens

<400> 358
Met Ser Thr Met Arg Leu Leu Thr Leu Ala Leu Leu Phe Ser Cys Ser 
1               5                   10                  15      


Val Ala Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile Gly Ala Val 
            20                  25                  30          


Leu Ser Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala Val Asn Gln 
        35                  40                  45              


Ala Asn Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn Ala Thr Ser 
    50                  55                  60                  


Val Thr His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser Val Cys Glu 
65                  70                  75                  80  


Asp Leu Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser His Pro Pro 
                85                  90                  95      


Thr Pro Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr Thr Ala Gly 
            100                 105                 110         


Phe Tyr Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met Ser Ile Tyr 
        115                 120                 125             


Ser Asp Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val Pro Pro Tyr 
    130                 135                 140                 


Ser His Gln Ser Ser Val Trp Phe Glu Met Met Arg Val Tyr Ser Trp 
145                 150                 155                 160 


Asn His Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly Arg Ala Ala 
                165                 170                 175     


Gln Lys Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser Lys Ser Lys 
            180                 185                 190         


Lys Arg Asn Tyr Glu Asn Leu Asp Gln Leu Ser Tyr Asp Asn Lys Arg 
        195                 200                 205             


Gly Pro Lys Ala Glu Lys Val Leu Gln Phe Asp Pro Gly Thr Lys Asn 
    210                 215                 220                 


Val Thr Ala Leu Leu Met Glu Ala Lys Glu Leu Glu Ala Arg Val Ile 
225                 230                 235                 240 


Ile Leu Ser Ala Ser Glu Asp Asp Ala Ala Thr Val Tyr Arg Ala Ala 
                245                 250                 255     


Ala Met Leu Asn Met Thr Gly Ser Gly Tyr Val Trp Leu Val Gly Glu 
            260                 265                 270         


Arg Glu Ile Ser Gly Asn Ala Leu Arg Tyr Ala Pro Asp Gly Ile Leu 
        275                 280                 285             


Gly Leu Gln Leu Ile Asn Gly Lys Asn Glu Ser Ala His Ile Ser Asp 
    290                 295                 300                 


Ala Val Gly Val Val Ala Gln Ala Val His Glu Leu Leu Glu Lys Glu 
305                 310                 315                 320 


Asn Ile Thr Asp Pro Pro Arg Gly Cys Val Gly Asn Thr Asn Ile Trp 
                325                 330                 335     


Lys Thr Gly Pro Leu Phe Lys Arg Val Leu Met Ser Ser Lys Tyr Ala 
            340                 345                 350         


Asp Gly Val Thr Gly Arg Val Glu Phe Asn Glu Asp Gly Asp Arg Lys 
        355                 360                 365             


Phe Ala Asn Tyr Ser Ile Met Asn Leu Gln Asn Arg Lys Leu Val Gln 
    370                 375                 380                 


Val Gly Ile Tyr Asn Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile 
385                 390                 395                 400 


Ile Trp Pro Gly Gly Glu Thr Glu Lys Pro Arg Gly Tyr Gln Met Ser 
                405                 410                 415     


Thr Arg Leu Lys Ile Val Thr Ile His Gln Glu Pro Phe Val Tyr Val 
            420                 425                 430         


Lys Pro Thr Leu Ser Asp Gly Thr Cys Lys Glu Glu Phe Thr Val Asn 
        435                 440                 445             


Gly Asp Pro Val Lys Lys Val Ile Cys Thr Gly Pro Asn Asp Thr Ser 
    450                 455                 460                 


Pro Gly Ser Pro Arg His Thr Val Pro Gln Cys Cys Tyr Gly Phe Cys 
465                 470                 475                 480 


Ile Asp Leu Leu Ile Lys Leu Ala Arg Thr Met Asn Phe Thr Tyr Glu 
                485                 490                 495     


Val His Leu Val Ala Asp Gly Lys Phe Gly Thr Gln Glu Arg Val Asn 
            500                 505                 510         


Asn Ser Asn Lys Lys Glu Trp Asn Gly Met Met Gly Glu Leu Leu Ser 
        515                 520                 525             


Gly Gln Ala Asp Met Ile Val Ala Pro Leu Thr Ile Asn Asn Glu Arg 
    530                 535                 540                 


Ala Gln Tyr Ile Glu Phe Ser Lys Pro Phe Lys Tyr Gln Gly Leu Thr 
545                 550                 555                 560 


Ile Leu Val Lys Lys Glu Ile Pro Arg Ser Thr Leu Asp Ser Phe Met 
                565                 570                 575     


Gln Pro Phe Gln Ser Thr Leu Trp Leu Leu Val Gly Leu Ser Val His 
            580                 585                 590         


Val Val Ala Val Met Leu Tyr Leu Leu Asp Arg Phe Ser Pro Phe Gly 
        595                 600                 605             


Arg Phe Lys Val Asn Ser Glu Glu Glu Glu Glu Asp Ala Leu Thr Leu 
    610                 615                 620                 


Ser Ser Ala Met Trp Phe Ser Trp Gly Val Leu Leu Asn Ser Gly Ile 
625                 630                 635                 640 


Gly Glu Gly Ala Pro Arg Ser Phe Ser Ala Arg Ile Leu Gly Met Val 
                645                 650                 655     


Trp Ala Gly Phe Ala Met Ile Ile Val Ala Ser Tyr Thr Ala Asn Leu 
            660                 665                 670         


Ala Ala Phe Leu Val Leu Asp Arg Pro Glu Glu Arg Ile Thr Gly Ile 
        675                 680                 685             


Asn Asp Pro Arg Leu Arg Asn Pro Ser Asp Lys Phe Ile Tyr Ala Thr 
    690                 695                 700                 


Val Lys Gln Ser Ser Val Asp Ile Tyr Phe Arg Arg Gln Val Glu Leu 
705                 710                 715                 720 


Ser Thr Met Tyr Arg His Met Glu Lys His Asn Tyr Glu Ser Ala Ala 
                725                 730                 735     


Glu Ala Ile Gln Ala Val Arg Asp Asn Lys Leu His Ala Phe Ile Trp 
            740                 745                 750         


Asp Ser Ala Val Leu Glu Phe Glu Ala Ser Gln Lys Cys Asp Leu Val 
        755                 760                 765             


Thr Thr Gly Glu Leu Phe Phe Arg Ser Gly Phe Gly Ile Gly Met Arg 
    770                 775                 780                 


Lys Asp Ser Pro Trp Lys Gln Asn Val Ser Leu Ser Ile Leu Lys Ser 
785                 790                 795                 800 


His Glu Asn Gly Phe Met Glu Asp Leu Asp Lys Thr Trp Val Arg Tyr 
                805                 810                 815     


Gln Glu Cys Asp Ser Arg Ser Asn Ala Pro Ala Thr Leu Thr Phe Glu 
            820                 825                 830         


Asn Met Ala Gly Val Phe Met Leu Val Ala Gly Gly Ile Val Ala Gly 
        835                 840                 845             


Ile Phe Leu Ile Phe Ile Glu Ile Ala Tyr Lys Arg His Lys Asp Ala 
    850                 855                 860                 


Arg Arg Lys Gln Met Gln Leu Ala Phe Ala Ala Val Asn Val Trp Arg 
865                 870                 875                 880 


Lys Asn Leu Gln Asp Arg Lys Ser Gly Arg Ala Glu Pro Asp Pro Lys 
                885                 890                 895     


Lys Lys Ala Thr Phe Arg Ala Ile Thr Ser Thr Leu Ala Ser Ser Phe 
            900                 905                 910         


Lys Arg Arg Arg Ser Ser Lys Asp Thr Gln Tyr His Pro Thr Asp Ile 
        915                 920                 925             


Thr Gly Pro Leu Asn Leu Ser Asp Pro Ser Val Ser Thr Val Val 
    930                 935                 940             


<210> 359

<400> 359
000


<210> 360

<400> 360
000


<210> 361

<400> 361
000


<210> 362
<211> 1194
<212> PRT
<213> Homo sapiens

<400> 362
Met Val Gly Leu Leu Leu Phe Phe Phe Pro Ala Ile Phe Leu Glu Val 
1               5                   10                  15      


Ser Leu Leu Pro Arg Ser Pro Gly Arg Lys Val Leu Leu Ala Gly Ala 
            20                  25                  30          


Ser Ser Gln Arg Ser Val Ala Arg Met Asp Gly Asp Val Ile Ile Gly 
        35                  40                  45              


Ala Leu Phe Ser Val His His Gln Pro Pro Ala Glu Lys Val Pro Glu 
    50                  55                  60                  


Arg Lys Cys Gly Glu Ile Arg Glu Gln Tyr Gly Ile Gln Arg Val Glu 
65                  70                  75                  80  


Ala Met Phe His Thr Leu Asp Lys Ile Asn Ala Asp Pro Val Leu Leu 
                85                  90                  95      


Pro Asn Ile Thr Leu Gly Ser Glu Ile Arg Asp Ser Cys Trp His Ser 
            100                 105                 110         


Ser Val Ala Leu Glu Gln Ser Ile Glu Phe Ile Arg Asp Ser Leu Ile 
        115                 120                 125             


Ser Ile Arg Asp Glu Lys Asp Gly Ile Asn Arg Cys Leu Pro Asp Gly 
    130                 135                 140                 


Gln Ser Leu Pro Pro Gly Arg Thr Lys Lys Pro Ile Ala Gly Val Ile 
145                 150                 155                 160 


Gly Pro Gly Ser Ser Ser Val Ala Ile Gln Val Gln Asn Leu Leu Gln 
                165                 170                 175     


Leu Phe Asp Ile Pro Gln Ile Ala Tyr Ser Ala Thr Ser Ile Asp Leu 
            180                 185                 190         


Ser Asp Lys Thr Leu Tyr Lys Tyr Phe Leu Arg Val Val Pro Ser Asp 
        195                 200                 205             


Thr Leu Gln Ala Arg Ala Met Leu Asp Ile Val Lys Arg Tyr Asn Trp 
    210                 215                 220                 


Thr Tyr Val Ser Ala Val His Thr Glu Gly Asn Tyr Gly Glu Ser Gly 
225                 230                 235                 240 


Met Asp Ala Phe Lys Glu Leu Ala Ala Gln Glu Gly Leu Cys Ile Ala 
                245                 250                 255     


His Ser Asp Lys Ile Tyr Ser Asn Ala Gly Glu Lys Ser Phe Asp Arg 
            260                 265                 270         


Leu Leu Arg Lys Leu Arg Glu Arg Leu Pro Lys Ala Arg Val Val Val 
        275                 280                 285             


Cys Phe Cys Glu Gly Met Thr Val Arg Gly Leu Leu Ser Ala Met Arg 
    290                 295                 300                 


Arg Leu Gly Val Val Gly Glu Phe Ser Leu Ile Gly Ser Asp Gly Trp 
305                 310                 315                 320 


Ala Asp Arg Asp Glu Val Ile Glu Gly Tyr Glu Val Glu Ala Asn Gly 
                325                 330                 335     


Gly Ile Thr Ile Lys Leu Gln Ser Pro Glu Val Arg Ser Phe Asp Asp 
            340                 345                 350         


Tyr Phe Leu Lys Leu Arg Leu Asp Thr Asn Thr Arg Asn Pro Trp Phe 
        355                 360                 365             


Pro Glu Phe Trp Gln His Arg Phe Gln Cys Arg Leu Pro Gly His Leu 
    370                 375                 380                 


Leu Glu Asn Pro Asn Phe Lys Arg Ile Cys Thr Gly Asn Glu Ser Leu 
385                 390                 395                 400 


Glu Glu Asn Tyr Val Gln Asp Ser Lys Met Gly Phe Val Ile Asn Ala 
                405                 410                 415     


Ile Tyr Ala Met Ala His Gly Leu Gln Asn Met His His Ala Leu Cys 
            420                 425                 430         


Pro Gly His Val Gly Leu Cys Asp Ala Met Lys Pro Ile Asp Gly Ser 
        435                 440                 445             


Lys Leu Leu Asp Phe Leu Ile Lys Ser Ser Phe Ile Gly Val Ser Gly 
    450                 455                 460                 


Glu Glu Val Trp Phe Asp Glu Lys Gly Asp Ala Pro Gly Arg Tyr Asp 
465                 470                 475                 480 


Ile Met Asn Leu Gln Tyr Thr Glu Ala Asn Arg Tyr Asp Tyr Val His 
                485                 490                 495     


Val Gly Thr Trp His Glu Gly Val Leu Asn Ile Asp Asp Tyr Lys Ile 
            500                 505                 510         


Gln Met Asn Lys Ser Gly Val Val Arg Ser Val Cys Ser Glu Pro Cys 
        515                 520                 525             


Leu Lys Gly Gln Ile Lys Val Ile Arg Lys Gly Glu Val Ser Cys Cys 
    530                 535                 540                 


Trp Ile Cys Thr Ala Cys Lys Glu Asn Glu Tyr Val Gln Asp Glu Phe 
545                 550                 555                 560 


Thr Cys Lys Ala Cys Asp Leu Gly Trp Trp Pro Asn Ala Asp Leu Thr 
                565                 570                 575     


Gly Cys Glu Pro Ile Pro Val Arg Tyr Leu Glu Trp Ser Asn Ile Glu 
            580                 585                 590         


Ser Ile Ile Ala Ile Ala Phe Ser Cys Leu Gly Ile Leu Val Thr Leu 
        595                 600                 605             


Phe Val Thr Leu Ile Phe Val Leu Tyr Arg Asp Thr Pro Val Val Lys 
    610                 615                 620                 


Ser Ser Ser Arg Glu Leu Cys Tyr Ile Ile Leu Ala Gly Ile Phe Leu 
625                 630                 635                 640 


Gly Tyr Val Cys Pro Phe Thr Leu Ile Ala Lys Pro Thr Thr Thr Ser 
                645                 650                 655     


Cys Tyr Leu Gln Arg Leu Leu Val Gly Leu Ser Ser Ala Met Cys Tyr 
            660                 665                 670         


Ser Ala Leu Val Thr Lys Thr Asn Arg Ile Ala Arg Ile Leu Ala Gly 
        675                 680                 685             


Ser Lys Lys Lys Ile Cys Thr Arg Lys Pro Arg Phe Met Ser Ala Trp 
    690                 695                 700                 


Ala Gln Val Ile Ile Ala Ser Ile Leu Ile Ser Val Gln Leu Thr Leu 
705                 710                 715                 720 


Val Val Thr Leu Ile Ile Met Glu Pro Pro Met Pro Ile Leu Ser Tyr 
                725                 730                 735     


Pro Ser Ile Lys Glu Val Tyr Leu Ile Cys Asn Thr Ser Asn Leu Gly 
            740                 745                 750         


Val Val Ala Pro Leu Gly Tyr Asn Gly Leu Leu Ile Met Ser Cys Thr 
        755                 760                 765             


Tyr Tyr Ala Phe Lys Thr Arg Asn Val Pro Ala Asn Phe Asn Glu Ala 
    770                 775                 780                 


Lys Tyr Ile Ala Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala 
785                 790                 795                 800 


Phe Val Pro Ile Tyr Phe Gly Ser Asn Tyr Lys Ile Ile Thr Thr Cys 
                805                 810                 815     


Phe Ala Val Ser Leu Ser Val Thr Val Ala Leu Gly Cys Met Phe Thr 
            820                 825                 830         


Pro Lys Met Tyr Ile Ile Ile Ala Lys Pro Glu Arg Asn Val Arg Ser 
        835                 840                 845             


Ala Phe Thr Thr Ser Asp Val Val Arg Met His Val Gly Asp Gly Lys 
    850                 855                 860                 


Leu Pro Cys Arg Ser Asn Thr Phe Leu Asn Ile Phe Arg Arg Lys Lys 
865                 870                 875                 880 


Ala Gly Ala Gly Asn Ala Asn Ser Asn Gly Lys Ser Val Ser Trp Ser 
                885                 890                 895     


Glu Pro Gly Gly Gly Gln Val Pro Lys Gly Gln His Met Trp His Arg 
            900                 905                 910         


Leu Ser Val His Val Lys Thr Asn Glu Thr Ala Cys Asn Gln Thr Ala 
        915                 920                 925             


Val Ile Lys Pro Leu Thr Lys Ser Tyr Gln Gly Ser Gly Lys Ser Leu 
    930                 935                 940                 


Thr Phe Ser Asp Thr Ser Thr Lys Thr Leu Tyr Asn Val Glu Glu Glu 
945                 950                 955                 960 


Glu Asp Ala Gln Pro Ile Arg Phe Ser Pro Pro Gly Ser Pro Ser Met 
                965                 970                 975     


Val Val His Arg Arg Val Pro Ser Ala Ala Thr Thr Pro Pro Leu Pro 
            980                 985                 990         


Ser His Leu Thr Ala Glu Glu Thr  Pro Leu Phe Leu Ala  Glu Pro Ala 
        995                 1000                 1005             


Leu Pro  Lys Gly Leu Pro Pro  Pro Leu Gln Gln Gln  Gln Gln Pro 
    1010                 1015                 1020             


Pro Pro  Gln Gln Lys Ser Leu  Met Asp Gln Leu Gln  Gly Val Val 
    1025                 1030                 1035             


Ser Asn  Phe Ser Thr Ala Ile  Pro Asp Phe His Ala  Val Leu Ala 
    1040                 1045                 1050             


Gly Pro  Gly Gly Pro Gly Asn  Gly Leu Arg Ser Leu  Tyr Pro Pro 
    1055                 1060                 1065             


Pro Pro  Pro Pro Gln His Leu  Gln Met Leu Pro Leu  Gln Leu Ser 
    1070                 1075                 1080             


Thr Phe  Gly Glu Glu Leu Val  Ser Pro Pro Ala Asp  Asp Asp Asp 
    1085                 1090                 1095             


Asp Ser  Glu Arg Phe Lys Leu  Leu Gln Glu Tyr Val  Tyr Glu His 
    1100                 1105                 1110             


Glu Arg  Glu Gly Asn Thr Glu  Glu Asp Glu Leu Glu  Glu Glu Glu 
    1115                 1120                 1125             


Glu Asp  Leu Gln Ala Ala Ser  Lys Leu Thr Pro Asp  Asp Ser Pro 
    1130                 1135                 1140             


Ala Leu  Thr Pro Pro Ser Pro  Phe Arg Asp Ser Val  Ala Ser Gly 
    1145                 1150                 1155             


Ser Ser  Val Pro Ser Ser Pro  Val Ser Glu Ser Val  Leu Cys Thr 
    1160                 1165                 1170             


Pro Pro  Asn Val Ser Tyr Ala  Ser Val Ile Leu Arg  Asp Tyr Lys 
    1175                 1180                 1185             


Gln Ser  Ser Ser Thr Leu 
    1190                 


<210> 363

<400> 363
000


<210> 364

<400> 364
000


<210> 365

<400> 365
000


<210> 366

<400> 366
000


<210> 367

<400> 367
000


<210> 368

<400> 368
000


<210> 369

<400> 369
000


<210> 370

<400> 370
000


<210> 371

<400> 371
000


<210> 372

<400> 372
000


<210> 373

<400> 373
000


<210> 374

<400> 374
000


<210> 375

<400> 375
000


<210> 376

<400> 376
000


<210> 377

<400> 377
000


<210> 378

<400> 378
000


<210> 379

<400> 379
000


<210> 380

<400> 380
000


<210> 381

<400> 381
000


<210> 382

<400> 382
000


<210> 383

<400> 383
000


<210> 384

<400> 384
000


<210> 385

<400> 385
000


<210> 386

<400> 386
000


<210> 387

<400> 387
000


<210> 388

<400> 388
000


<210> 389

<400> 389
000


<210> 390

<400> 390
000


<210> 391

<400> 391
000


<210> 392

<400> 392
000


<210> 393

<400> 393
000


<210> 394

<400> 394
000


<210> 395

<400> 395
000


<210> 396

<400> 396
000


<210> 397

<400> 397
000


<210> 398

<400> 398
000


<210> 399

<400> 399
000


<210> 400

<400> 400
000


<210> 401

<400> 401
000


<210> 402

<400> 402
000


<210> 403

<400> 403
000


<210> 404

<400> 404
000


<210> 405

<400> 405
000


<210> 406

<400> 406
000


<210> 407

<400> 407
000


<210> 408

<400> 408
000


<210> 409

<400> 409
000


<210> 410

<400> 410
000


<210> 411

<400> 411
000


<210> 412

<400> 412
000


<210> 413

<400> 413
000


<210> 414

<400> 414
000


<210> 415

<400> 415
000


<210> 416

<400> 416
000


<210> 417

<400> 417
000


<210> 418

<400> 418
000


<210> 419

<400> 419
000


<210> 420

<400> 420
000


<210> 421

<400> 421
000


<210> 422

<400> 422
000


<210> 423

<400> 423
000


<210> 424

<400> 424
000


<210> 425

<400> 425
000


<210> 426

<400> 426
000


<210> 427

<400> 427
000


<210> 428

<400> 428
000


<210> 429

<400> 429
000


<210> 430

<400> 430
000


<210> 431

<400> 431
000


<210> 432

<400> 432
000


<210> 433

<400> 433
000


<210> 434

<400> 434
000


<210> 435

<400> 435
000


<210> 436

<400> 436
000


<210> 437

<400> 437
000


<210> 438

<400> 438
000


<210> 439

<400> 439
000


<210> 440

<400> 440
000


<210> 441

<400> 441
000


<210> 442

<400> 442
000


<210> 443

<400> 443
000


<210> 444

<400> 444
000


<210> 445

<400> 445
000


<210> 446

<400> 446
000


<210> 447

<400> 447
000


<210> 448

<400> 448
000


<210> 449

<400> 449
000


<210> 450

<400> 450
000


<210> 451

<400> 451
000


<210> 452

<400> 452
000


<210> 453

<400> 453
000


<210> 454

<400> 454
000


<210> 455

<400> 455
000


<210> 456

<400> 456
000


<210> 457

<400> 457
000


<210> 458

<400> 458
000


<210> 459

<400> 459
000


<210> 460

<400> 460
000


<210> 461

<400> 461
000


<210> 462

<400> 462
000


<210> 463

<400> 463
000


<210> 464

<400> 464
000


<210> 465

<400> 465
000


<210> 466

<400> 466
000


<210> 467

<400> 467
000


<210> 468

<400> 468
000


<210> 469

<400> 469
000


<210> 470

<400> 470
000


<210> 471

<400> 471
000


<210> 472

<400> 472
000


<210> 473

<400> 473
000


<210> 474

<400> 474
000


<210> 475

<400> 475
000


<210> 476

<400> 476
000


<210> 477

<400> 477
000


<210> 478

<400> 478
000


<210> 479

<400> 479
000


<210> 480

<400> 480
000


<210> 481

<400> 481
000


<210> 482

<400> 482
000


<210> 483

<400> 483
000


<210> 484

<400> 484
000


<210> 485

<400> 485
000


<210> 486

<400> 486
000


<210> 487

<400> 487
000


<210> 488

<400> 488
000


<210> 489

<400> 489
000


<210> 490

<400> 490
000


<210> 491

<400> 491
000


<210> 492

<400> 492
000


<210> 493

<400> 493
000


<210> 494

<400> 494
000


<210> 495

<400> 495
000


<210> 496

<400> 496
000


<210> 497

<400> 497
000


<210> 498

<400> 498
000


<210> 499

<400> 499
000


<210> 500

<400> 500
000


<210> 501

<400> 501
000


<210> 502

<400> 502
000


<210> 503

<400> 503
000


<210> 504

<400> 504
000


<210> 505

<400> 505
000


<210> 506

<400> 506
000


<210> 507

<400> 507
000


<210> 508

<400> 508
000


<210> 509

<400> 509
000


<210> 510

<400> 510
000


<210> 511

<400> 511
000


<210> 512

<400> 512
000


<210> 513

<400> 513
000


<210> 514

<400> 514
000


<210> 515

<400> 515
000


<210> 516

<400> 516
000


<210> 517

<400> 517
000


<210> 518

<400> 518
000


<210> 519

<400> 519
000


<210> 520

<400> 520
000


<210> 521

<400> 521
000


<210> 522

<400> 522
000


<210> 523

<400> 523
000


<210> 524

<400> 524
000


<210> 525

<400> 525
000


<210> 526

<400> 526
000


<210> 527

<400> 527
000


<210> 528

<400> 528
000


<210> 529

<400> 529
000


<210> 530

<400> 530
000


<210> 531

<400> 531
000


<210> 532

<400> 532
000


<210> 533

<400> 533
000


<210> 534

<400> 534
000


<210> 535

<400> 535
000


<210> 536

<400> 536
000


<210> 537

<400> 537
000


<210> 538

<400> 538
000


<210> 539

<400> 539
000


<210> 540

<400> 540
000


<210> 541

<400> 541
000


<210> 542

<400> 542
000


<210> 543

<400> 543
000


<210> 544

<400> 544
000


<210> 545

<400> 545
000


<210> 546
<211> 2549
<212> PRT
<213> Homo sapiens

<400> 546
Met Leu Gly Thr Gly Pro Ala Ala Ala Thr Thr Ala Ala Thr Thr Ser 
1               5                   10                  15      


Ser Asn Val Ser Val Leu Gln Gln Phe Ala Ser Gly Leu Lys Ser Arg 
            20                  25                  30          


Asn Glu Glu Thr Arg Ala Lys Ala Ala Lys Glu Leu Gln His Tyr Val 
        35                  40                  45              


Thr Met Glu Leu Arg Glu Met Ser Gln Glu Glu Ser Thr Arg Phe Tyr 
    50                  55                  60                  


Asp Gln Leu Asn His His Ile Phe Glu Leu Val Ser Ser Ser Asp Ala 
65                  70                  75                  80  


Asn Glu Arg Lys Gly Gly Ile Leu Ala Ile Ala Ser Leu Ile Gly Val 
                85                  90                  95      


Glu Gly Gly Asn Ala Thr Arg Ile Gly Arg Phe Ala Asn Tyr Leu Arg 
            100                 105                 110         


Asn Leu Leu Pro Ser Asn Asp Pro Val Val Met Glu Met Ala Ser Lys 
        115                 120                 125             


Ala Ile Gly Arg Leu Ala Met Ala Gly Asp Thr Phe Thr Ala Glu Tyr 
    130                 135                 140                 


Val Glu Phe Glu Val Lys Arg Ala Leu Glu Trp Leu Gly Ala Asp Arg 
145                 150                 155                 160 


Asn Glu Gly Arg Arg His Ala Ala Val Leu Val Leu Arg Glu Leu Ala 
                165                 170                 175     


Ile Ser Val Pro Thr Phe Phe Phe Gln Gln Val Gln Pro Phe Phe Asp 
            180                 185                 190         


Asn Ile Phe Val Ala Val Trp Asp Pro Lys Gln Ala Ile Arg Glu Gly 
        195                 200                 205             


Ala Val Ala Ala Leu Arg Ala Cys Leu Ile Leu Thr Thr Gln Arg Glu 
    210                 215                 220                 


Pro Lys Glu Met Gln Lys Pro Gln Trp Tyr Arg His Thr Phe Glu Glu 
225                 230                 235                 240 


Ala Glu Lys Gly Phe Asp Glu Thr Leu Ala Lys Glu Lys Gly Met Asn 
                245                 250                 255     


Arg Asp Asp Arg Ile His Gly Ala Leu Leu Ile Leu Asn Glu Leu Val 
            260                 265                 270         


Arg Ile Ser Ser Met Glu Gly Glu Arg Leu Arg Glu Glu Met Glu Glu 
        275                 280                 285             


Ile Thr Gln Gln Gln Leu Val His Asp Lys Tyr Cys Lys Asp Leu Met 
    290                 295                 300                 


Gly Phe Gly Thr Lys Pro Arg His Ile Thr Pro Phe Thr Ser Phe Gln 
305                 310                 315                 320 


Ala Val Gln Pro Gln Gln Ser Asn Ala Leu Val Gly Leu Leu Gly Tyr 
                325                 330                 335     


Ser Ser His Gln Gly Leu Met Gly Phe Gly Thr Ser Pro Ser Pro Ala 
            340                 345                 350         


Lys Ser Thr Leu Val Glu Ser Arg Cys Cys Arg Asp Leu Met Glu Glu 
        355                 360                 365             


Lys Phe Asp Gln Val Cys Gln Trp Val Leu Lys Cys Arg Asn Ser Lys 
    370                 375                 380                 


Asn Ser Leu Ile Gln Met Thr Ile Leu Asn Leu Leu Pro Arg Leu Ala 
385                 390                 395                 400 


Ala Phe Arg Pro Ser Ala Phe Thr Asp Thr Gln Tyr Leu Gln Asp Thr 
                405                 410                 415     


Met Asn His Val Leu Ser Cys Val Lys Lys Glu Lys Glu Arg Thr Ala 
            420                 425                 430         


Ala Phe Gln Ala Leu Gly Leu Leu Ser Val Ala Val Arg Ser Glu Phe 
        435                 440                 445             


Lys Val Tyr Leu Pro Arg Val Leu Asp Ile Ile Arg Ala Ala Leu Pro 
    450                 455                 460                 


Pro Lys Asp Phe Ala His Lys Arg Gln Lys Ala Met Gln Val Asp Ala 
465                 470                 475                 480 


Thr Val Phe Thr Cys Ile Ser Met Leu Ala Arg Ala Met Gly Pro Gly 
                485                 490                 495     


Ile Gln Gln Asp Ile Lys Glu Leu Leu Glu Pro Met Leu Ala Val Gly 
            500                 505                 510         


Leu Ser Pro Ala Leu Thr Ala Val Leu Tyr Asp Leu Ser Arg Gln Ile 
        515                 520                 525             


Pro Gln Leu Lys Lys Asp Ile Gln Asp Gly Leu Leu Lys Met Leu Ser 
    530                 535                 540                 


Leu Val Leu Met His Lys Pro Leu Arg His Pro Gly Met Pro Lys Gly 
545                 550                 555                 560 


Leu Ala His Gln Leu Ala Ser Pro Gly Leu Thr Thr Leu Pro Glu Ala 
                565                 570                 575     


Ser Asp Val Gly Ser Ile Thr Leu Ala Leu Arg Thr Leu Gly Ser Phe 
            580                 585                 590         


Glu Phe Glu Gly His Ser Leu Thr Gln Phe Val Arg His Cys Ala Asp 
        595                 600                 605             


His Phe Leu Asn Ser Glu His Lys Glu Ile Arg Met Glu Ala Ala Arg 
    610                 615                 620                 


Thr Cys Ser Arg Leu Leu Thr Pro Ser Ile His Leu Ile Ser Gly His 
625                 630                 635                 640 


Ala His Val Val Ser Gln Thr Ala Val Gln Val Val Ala Asp Val Leu 
                645                 650                 655     


Ser Lys Leu Leu Val Val Gly Ile Thr Asp Pro Asp Pro Asp Ile Arg 
            660                 665                 670         


Tyr Cys Val Leu Ala Ser Leu Asp Glu Arg Phe Asp Ala His Leu Ala 
        675                 680                 685             


Gln Ala Glu Asn Leu Gln Ala Leu Phe Val Ala Leu Asn Asp Gln Val 
    690                 695                 700                 


Phe Glu Ile Arg Glu Leu Ala Ile Cys Thr Val Gly Arg Leu Ser Ser 
705                 710                 715                 720 


Met Asn Pro Ala Phe Val Met Pro Phe Leu Arg Lys Met Leu Ile Gln 
                725                 730                 735     


Ile Leu Thr Glu Leu Glu His Ser Gly Ile Gly Arg Ile Lys Glu Gln 
            740                 745                 750         


Ser Ala Arg Met Leu Gly His Leu Val Ser Asn Ala Pro Arg Leu Ile 
        755                 760                 765             


Arg Pro Tyr Met Glu Pro Ile Leu Lys Ala Leu Ile Leu Lys Leu Lys 
    770                 775                 780                 


Asp Pro Asp Pro Asp Pro Asn Pro Gly Val Ile Asn Asn Val Leu Ala 
785                 790                 795                 800 


Thr Ile Gly Glu Leu Ala Gln Val Ser Gly Leu Glu Met Arg Lys Trp 
                805                 810                 815     


Val Asp Glu Leu Phe Ile Ile Ile Met Asp Met Leu Gln Asp Ser Ser 
            820                 825                 830         


Leu Leu Ala Lys Arg Gln Val Ala Leu Trp Thr Leu Gly Gln Leu Val 
        835                 840                 845             


Ala Ser Thr Gly Tyr Val Val Glu Pro Tyr Arg Lys Tyr Pro Thr Leu 
    850                 855                 860                 


Leu Glu Val Leu Leu Asn Phe Leu Lys Thr Glu Gln Asn Gln Gly Thr 
865                 870                 875                 880 


Arg Arg Glu Ala Ile Arg Val Leu Gly Leu Leu Gly Ala Leu Asp Pro 
                885                 890                 895     


Tyr Lys His Lys Val Asn Ile Gly Met Ile Asp Gln Ser Arg Asp Ala 
            900                 905                 910         


Ser Ala Val Ser Leu Ser Glu Ser Lys Ser Ser Gln Asp Ser Ser Asp 
        915                 920                 925             


Tyr Ser Thr Ser Glu Met Leu Val Asn Met Gly Asn Leu Pro Leu Asp 
    930                 935                 940                 


Glu Phe Tyr Pro Ala Val Ser Met Val Ala Leu Met Arg Ile Phe Arg 
945                 950                 955                 960 


Asp Gln Ser Leu Ser His His His Thr Met Val Val Gln Ala Ile Thr 
                965                 970                 975     


Phe Ile Phe Lys Ser Leu Gly Leu Lys Cys Val Gln Phe Leu Pro Gln 
            980                 985                 990         


Val Met Pro Thr Phe Leu Asn Val  Ile Arg Val Cys Asp  Gly Ala Ile 
        995                 1000                 1005             


Arg Glu  Phe Leu Phe Gln Gln  Leu Gly Met Leu Val  Ser Phe Val 
    1010                 1015                 1020             


Lys Ser  His Ile Arg Pro Tyr  Met Asp Glu Ile Val  Thr Leu Met 
    1025                 1030                 1035             


Arg Glu  Phe Trp Val Met Asn  Thr Ser Ile Gln Ser  Thr Ile Ile 
    1040                 1045                 1050             


Leu Leu  Ile Glu Gln Ile Val  Val Ala Leu Gly Gly  Glu Phe Lys 
    1055                 1060                 1065             


Leu Tyr  Leu Pro Gln Leu Ile  Pro His Met Leu Arg  Val Phe Met 
    1070                 1075                 1080             


His Asp  Asn Ser Pro Gly Arg  Ile Val Ser Ile Lys  Leu Leu Ala 
    1085                 1090                 1095             


Ala Ile  Gln Leu Phe Gly Ala  Asn Leu Asp Asp Tyr  Leu His Leu 
    1100                 1105                 1110             


Leu Leu  Pro Pro Ile Val Lys  Leu Phe Asp Ala Pro  Glu Ala Pro 
    1115                 1120                 1125             


Leu Pro  Ser Arg Lys Ala Ala  Leu Glu Thr Val Asp  Arg Leu Thr 
    1130                 1135                 1140             


Glu Ser  Leu Asp Phe Thr Asp  Tyr Ala Ser Arg Ile  Ile His Pro 
    1145                 1150                 1155             


Ile Val  Arg Thr Leu Asp Gln  Ser Pro Glu Leu Arg  Ser Thr Ala 
    1160                 1165                 1170             


Met Asp  Thr Leu Ser Ser Leu  Val Phe Gln Leu Gly  Lys Lys Tyr 
    1175                 1180                 1185             


Gln Ile  Phe Ile Pro Met Val  Asn Lys Val Leu Val  Arg His Arg 
    1190                 1195                 1200             


Ile Asn  His Gln Arg Tyr Asp  Val Leu Ile Cys Arg  Ile Val Lys 
    1205                 1210                 1215             


Gly Tyr  Thr Leu Ala Asp Glu  Glu Glu Asp Pro Leu  Ile Tyr Gln 
    1220                 1225                 1230             


His Arg  Met Leu Arg Ser Gly  Gln Gly Asp Ala Leu  Ala Ser Gly 
    1235                 1240                 1245             


Pro Val  Glu Thr Gly Pro Met  Lys Lys Leu His Val  Ser Thr Ile 
    1250                 1255                 1260             


Asn Leu  Gln Lys Ala Trp Gly  Ala Ala Arg Arg Val  Ser Lys Asp 
    1265                 1270                 1275             


Asp Trp  Leu Glu Trp Leu Arg  Arg Leu Ser Leu Glu  Leu Leu Lys 
    1280                 1285                 1290             


Asp Ser  Ser Ser Pro Ser Leu  Arg Ser Cys Trp Ala  Leu Ala Gln 
    1295                 1300                 1305             


Ala Tyr  Asn Pro Met Ala Arg  Asp Leu Phe Asn Ala  Ala Phe Val 
    1310                 1315                 1320             


Ser Cys  Trp Ser Glu Leu Asn  Glu Asp Gln Gln Asp  Glu Leu Ile 
    1325                 1330                 1335             


Arg Ser  Ile Glu Leu Ala Leu  Thr Ser Gln Asp Ile  Ala Glu Val 
    1340                 1345                 1350             


Thr Gln  Thr Leu Leu Asn Leu  Ala Glu Phe Met Glu  His Ser Asp 
    1355                 1360                 1365             


Lys Gly  Pro Leu Pro Leu Arg  Asp Asp Asn Gly Ile  Val Leu Leu 
    1370                 1375                 1380             


Gly Glu  Arg Ala Ala Lys Cys  Arg Ala Tyr Ala Lys  Ala Leu His 
    1385                 1390                 1395             


Tyr Lys  Glu Leu Glu Phe Gln  Lys Gly Pro Thr Pro  Ala Ile Leu 
    1400                 1405                 1410             


Glu Ser  Leu Ile Ser Ile Asn  Asn Lys Leu Gln Gln  Pro Glu Ala 
    1415                 1420                 1425             


Ala Ala  Gly Val Leu Glu Tyr  Ala Met Lys His Phe  Gly Glu Leu 
    1430                 1435                 1440             


Glu Ile  Gln Ala Thr Trp Tyr  Glu Lys Leu His Glu  Trp Glu Asp 
    1445                 1450                 1455             


Ala Leu  Val Ala Tyr Asp Lys  Lys Met Asp Thr Asn  Lys Asp Asp 
    1460                 1465                 1470             


Pro Glu  Leu Met Leu Gly Arg  Met Arg Cys Leu Glu  Ala Leu Gly 
    1475                 1480                 1485             


Glu Trp  Gly Gln Leu His Gln  Gln Cys Cys Glu Lys  Trp Thr Leu 
    1490                 1495                 1500             


Val Asn  Asp Glu Thr Gln Ala  Lys Met Ala Arg Met  Ala Ala Ala 
    1505                 1510                 1515             


Ala Ala  Trp Gly Leu Gly Gln  Trp Asp Ser Met Glu  Glu Tyr Thr 
    1520                 1525                 1530             


Cys Met  Ile Pro Arg Asp Thr  His Asp Gly Ala Phe  Tyr Arg Ala 
    1535                 1540                 1545             


Val Leu  Ala Leu His Gln Asp  Leu Phe Ser Leu Ala  Gln Gln Cys 
    1550                 1555                 1560             


Ile Asp  Lys Ala Arg Asp Leu  Leu Asp Ala Glu Leu  Thr Ala Met 
    1565                 1570                 1575             


Ala Gly  Glu Ser Tyr Ser Arg  Ala Tyr Gly Ala Met  Val Ser Cys 
    1580                 1585                 1590             


His Met  Leu Ser Glu Leu Glu  Glu Val Ile Gln Tyr  Lys Leu Val 
    1595                 1600                 1605             


Pro Glu  Arg Arg Glu Ile Ile  Arg Gln Ile Trp Trp  Glu Arg Leu 
    1610                 1615                 1620             


Gln Gly  Cys Gln Arg Ile Val  Glu Asp Trp Gln Lys  Ile Leu Met 
    1625                 1630                 1635             


Val Arg  Ser Leu Val Val Ser  Pro His Glu Asp Met  Arg Thr Trp 
    1640                 1645                 1650             


Leu Lys  Tyr Ala Ser Leu Cys  Gly Lys Ser Gly Arg  Leu Ala Leu 
    1655                 1660                 1665             


Ala His  Lys Thr Leu Val Leu  Leu Leu Gly Val Asp  Pro Ser Arg 
    1670                 1675                 1680             


Gln Leu  Asp His Pro Leu Pro  Thr Val His Pro Gln  Val Thr Tyr 
    1685                 1690                 1695             


Ala Tyr  Met Lys Asn Met Trp  Lys Ser Ala Arg Lys  Ile Asp Ala 
    1700                 1705                 1710             


Phe Gln  His Met Gln His Phe  Val Gln Thr Met Gln  Gln Gln Ala 
    1715                 1720                 1725             


Gln His  Ala Ile Ala Thr Glu  Asp Gln Gln His Lys  Gln Glu Leu 
    1730                 1735                 1740             


His Lys  Leu Met Ala Arg Cys  Phe Leu Lys Leu Gly  Glu Trp Gln 
    1745                 1750                 1755             


Leu Asn  Leu Gln Gly Ile Asn  Glu Ser Thr Ile Pro  Lys Val Leu 
    1760                 1765                 1770             


Gln Tyr  Tyr Ser Ala Ala Thr  Glu His Asp Arg Ser  Trp Tyr Lys 
    1775                 1780                 1785             


Ala Trp  His Ala Trp Ala Val  Met Asn Phe Glu Ala  Val Leu His 
    1790                 1795                 1800             


Tyr Lys  His Gln Asn Gln Ala  Arg Asp Glu Lys Lys  Lys Leu Arg 
    1805                 1810                 1815             


His Ala  Ser Gly Ala Asn Ile  Thr Asn Ala Thr Thr  Ala Ala Thr 
    1820                 1825                 1830             


Thr Ala  Ala Thr Ala Thr Thr  Thr Ala Ser Thr Glu  Gly Ser Asn 
    1835                 1840                 1845             


Ser Glu  Ser Glu Ala Glu Ser  Thr Glu Asn Ser Pro  Thr Pro Ser 
    1850                 1855                 1860             


Pro Leu  Gln Lys Lys Val Thr  Glu Asp Leu Ser Lys  Thr Leu Leu 
    1865                 1870                 1875             


Met Tyr  Thr Val Pro Ala Val  Gln Gly Phe Phe Arg  Ser Ile Ser 
    1880                 1885                 1890             


Leu Ser  Arg Gly Asn Asn Leu  Gln Asp Thr Leu Arg  Val Leu Thr 
    1895                 1900                 1905             


Leu Trp  Phe Asp Tyr Gly His  Trp Pro Asp Val Asn  Glu Ala Leu 
    1910                 1915                 1920             


Val Glu  Gly Val Lys Ala Ile  Gln Ile Asp Thr Trp  Leu Gln Val 
    1925                 1930                 1935             


Ile Pro  Gln Leu Ile Ala Arg  Ile Asp Thr Pro Arg  Pro Leu Val 
    1940                 1945                 1950             


Gly Arg  Leu Ile His Gln Leu  Leu Thr Asp Ile Gly  Arg Tyr His 
    1955                 1960                 1965             


Pro Gln  Ala Leu Ile Tyr Pro  Leu Thr Val Ala Ser  Lys Ser Thr 
    1970                 1975                 1980             


Thr Thr  Ala Arg His Asn Ala  Ala Asn Lys Ile Leu  Lys Asn Met 
    1985                 1990                 1995             


Cys Glu  His Ser Asn Thr Leu  Val Gln Gln Ala Met  Met Val Ser 
    2000                 2005                 2010             


Glu Glu  Leu Ile Arg Val Ala  Ile Leu Trp His Glu  Met Trp His 
    2015                 2020                 2025             


Glu Gly  Leu Glu Glu Ala Ser  Arg Leu Tyr Phe Gly  Glu Arg Asn 
    2030                 2035                 2040             


Val Lys  Gly Met Phe Glu Val  Leu Glu Pro Leu His  Ala Met Met 
    2045                 2050                 2055             


Glu Arg  Gly Pro Gln Thr Leu  Lys Glu Thr Ser Phe  Asn Gln Ala 
    2060                 2065                 2070             


Tyr Gly  Arg Asp Leu Met Glu  Ala Gln Glu Trp Cys  Arg Lys Tyr 
    2075                 2080                 2085             


Met Lys  Ser Gly Asn Val Lys  Asp Leu Thr Gln Ala  Trp Asp Leu 
    2090                 2095                 2100             


Tyr Tyr  His Val Phe Arg Arg  Ile Ser Lys Gln Leu  Pro Gln Leu 
    2105                 2110                 2115             


Thr Ser  Leu Glu Leu Gln Tyr  Val Ser Pro Lys Leu  Leu Met Cys 
    2120                 2125                 2130             


Arg Asp  Leu Glu Leu Ala Val  Pro Gly Thr Tyr Asp  Pro Asn Gln 
    2135                 2140                 2145             


Pro Ile  Ile Arg Ile Gln Ser  Ile Ala Pro Ser Leu  Gln Val Ile 
    2150                 2155                 2160             


Thr Ser  Lys Gln Arg Pro Arg  Lys Leu Thr Leu Met  Gly Ser Asn 
    2165                 2170                 2175             


Gly His  Glu Phe Val Phe Leu  Leu Lys Gly His Glu  Asp Leu Arg 
    2180                 2185                 2190             


Gln Asp  Glu Arg Val Met Gln  Leu Phe Gly Leu Val  Asn Thr Leu 
    2195                 2200                 2205             


Leu Ala  Asn Asp Pro Thr Ser  Leu Arg Lys Asn Leu  Ser Ile Gln 
    2210                 2215                 2220             


Arg Tyr  Ala Val Ile Pro Leu  Ser Thr Asn Ser Gly  Leu Ile Gly 
    2225                 2230                 2235             


Trp Val  Pro His Cys Asp Thr  Leu His Ala Leu Ile  Arg Asp Tyr 
    2240                 2245                 2250             


Arg Glu  Lys Lys Lys Ile Leu  Leu Asn Ile Glu His  Arg Ile Met 
    2255                 2260                 2265             


Leu Arg  Met Ala Pro Asp Tyr  Asp His Leu Thr Leu  Met Gln Lys 
    2270                 2275                 2280             


Val Glu  Val Phe Glu His Ala  Val Asn Asn Thr Ala  Gly Asp Asp 
    2285                 2290                 2295             


Leu Ala  Lys Leu Leu Trp Leu  Lys Ser Pro Ser Ser  Glu Val Trp 
    2300                 2305                 2310             


Phe Asp  Arg Arg Thr Asn Tyr  Thr Arg Ser Leu Ala  Val Met Ser 
    2315                 2320                 2325             


Met Val  Gly Tyr Ile Leu Gly  Leu Gly Asp Arg His  Pro Ser Asn 
    2330                 2335                 2340             


Leu Met  Leu Asp Arg Leu Ser  Gly Lys Ile Leu His  Ile Asp Phe 
    2345                 2350                 2355             


Gly Asp  Cys Phe Glu Val Ala  Met Thr Arg Glu Lys  Phe Pro Glu 
    2360                 2365                 2370             


Lys Ile  Pro Phe Arg Leu Thr  Arg Met Leu Thr Asn  Ala Met Glu 
    2375                 2380                 2385             


Val Thr  Gly Leu Asp Gly Asn  Tyr Arg Ile Thr Cys  His Thr Val 
    2390                 2395                 2400             


Met Glu  Val Leu Arg Glu His  Lys Asp Ser Val Met  Ala Val Leu 
    2405                 2410                 2415             


Glu Ala  Phe Val Tyr Asp Pro  Leu Leu Asn Trp Arg  Leu Met Asp 
    2420                 2425                 2430             


Thr Asn  Thr Lys Gly Asn Lys  Arg Ser Arg Thr Arg  Thr Asp Ser 
    2435                 2440                 2445             


Tyr Ser  Ala Gly Gln Ser Val  Glu Ile Leu Asp Gly  Val Glu Leu 
    2450                 2455                 2460             


Gly Glu  Pro Ala His Lys Lys  Thr Gly Thr Thr Val  Pro Glu Ser 
    2465                 2470                 2475             


Ile His  Ser Phe Ile Gly Asp  Gly Leu Val Lys Pro  Glu Ala Leu 
    2480                 2485                 2490             


Asn Lys  Lys Ala Ile Gln Ile  Ile Asn Arg Val Arg  Asp Lys Leu 
    2495                 2500                 2505             


Thr Gly  Arg Asp Phe Ser His  Asp Asp Thr Leu Asp  Val Pro Thr 
    2510                 2515                 2520             


Gln Val  Glu Leu Leu Ile Lys  Gln Ala Thr Ser His  Glu Asn Leu 
    2525                 2530                 2535             


Cys Gln  Cys Tyr Ile Gly Trp  Cys Pro Phe Trp 
    2540                 2545                 


<210> 547

<400> 547
000


<210> 548

<400> 548
000


<210> 549

<400> 549
000


<210> 550

<400> 550
000


<210> 551

<400> 551
000


<210> 552

<400> 552
000


<210> 553

<400> 553
000


<210> 554

<400> 554
000


<210> 555

<400> 555
000


<210> 556

<400> 556
000


<210> 557

<400> 557
000


<210> 558

<400> 558
000


<210> 559

<400> 559
000


<210> 560

<400> 560
000


<210> 561

<400> 561
000


<210> 562

<400> 562
000


<210> 563

<400> 563
000


<210> 564

<400> 564
000


<210> 565

<400> 565
000


<210> 566

<400> 566
000


<210> 567

<400> 567
000


<210> 568

<400> 568
000


<210> 569

<400> 569
000


<210> 570

<400> 570
000


<210> 571
<211> 2839
<212> PRT
<213> Homo sapiens

<400> 571
Met Ala Ala His Arg Pro Val Glu Trp Val Gln Ala Val Val Ser Arg 
1               5                   10                  15      


Phe Asp Glu Gln Leu Pro Ile Lys Thr Gly Gln Gln Asn Thr His Thr 
            20                  25                  30          


Lys Val Ser Thr Glu His Asn Lys Glu Cys Leu Ile Asn Ile Ser Lys 
        35                  40                  45              


Tyr Lys Phe Ser Leu Val Ile Ser Gly Leu Thr Thr Ile Leu Lys Asn 
    50                  55                  60                  


Val Asn Asn Met Arg Ile Phe Gly Glu Ala Ala Glu Lys Asn Leu Tyr 
65                  70                  75                  80  


Leu Ser Gln Leu Ile Ile Leu Asp Thr Leu Glu Lys Cys Leu Ala Gly 
                85                  90                  95      


Gln Pro Lys Asp Thr Met Arg Leu Asp Glu Thr Met Leu Val Lys Gln 
            100                 105                 110         


Leu Leu Pro Glu Ile Cys His Phe Leu His Thr Cys Arg Glu Gly Asn 
        115                 120                 125             


Gln His Ala Ala Glu Leu Arg Asn Ser Ala Ser Gly Val Leu Phe Ser 
    130                 135                 140                 


Leu Ser Cys Asn Asn Phe Asn Ala Val Phe Ser Arg Ile Ser Thr Arg 
145                 150                 155                 160 


Leu Gln Glu Leu Thr Val Cys Ser Glu Asp Asn Val Asp Val His Asp 
                165                 170                 175     


Ile Glu Leu Leu Gln Tyr Ile Asn Val Asp Cys Ala Lys Leu Lys Arg 
            180                 185                 190         


Leu Leu Lys Glu Thr Ala Phe Lys Phe Lys Ala Leu Lys Lys Val Ala 
        195                 200                 205             


Gln Leu Ala Val Ile Asn Ser Leu Glu Lys Ala Phe Trp Asn Trp Val 
    210                 215                 220                 


Glu Asn Tyr Pro Asp Glu Phe Thr Lys Leu Tyr Gln Ile Pro Gln Thr 
225                 230                 235                 240 


Asp Met Ala Glu Cys Ala Glu Lys Leu Phe Asp Leu Val Asp Gly Phe 
                245                 250                 255     


Ala Glu Ser Thr Lys Arg Lys Ala Ala Val Trp Pro Leu Gln Ile Ile 
            260                 265                 270         


Leu Leu Ile Leu Cys Pro Glu Ile Ile Gln Asp Ile Ser Lys Asp Val 
        275                 280                 285             


Val Asp Glu Asn Asn Met Asn Lys Lys Leu Phe Leu Asp Ser Leu Arg 
    290                 295                 300                 


Lys Ala Leu Ala Gly His Gly Gly Ser Arg Gln Leu Thr Glu Ser Ala 
305                 310                 315                 320 


Ala Ile Ala Cys Val Lys Leu Cys Lys Ala Ser Thr Tyr Ile Asn Trp 
                325                 330                 335     


Glu Asp Asn Ser Val Ile Phe Leu Leu Val Gln Ser Met Val Val Asp 
            340                 345                 350         


Leu Lys Asn Leu Leu Phe Asn Pro Ser Lys Pro Phe Ser Arg Gly Ser 
        355                 360                 365             


Gln Pro Ala Asp Val Asp Leu Met Ile Asp Cys Leu Val Ser Cys Phe 
    370                 375                 380                 


Arg Ile Ser Pro His Asn Asn Gln His Phe Lys Ile Cys Leu Ala Gln 
385                 390                 395                 400 


Asn Ser Pro Ser Thr Phe His Tyr Val Leu Val Asn Ser Leu His Arg 
                405                 410                 415     


Ile Ile Thr Asn Ser Ala Leu Asp Trp Trp Pro Lys Ile Asp Ala Val 
            420                 425                 430         


Tyr Cys His Ser Val Glu Leu Arg Asn Met Phe Gly Glu Thr Leu His 
        435                 440                 445             


Lys Ala Val Gln Gly Cys Gly Ala His Pro Ala Ile Arg Met Ala Pro 
    450                 455                 460                 


Ser Leu Thr Phe Lys Glu Lys Val Thr Ser Leu Lys Phe Lys Glu Lys 
465                 470                 475                 480 


Pro Thr Asp Leu Glu Thr Arg Ser Tyr Lys Tyr Leu Leu Leu Ser Met 
                485                 490                 495     


Val Lys Leu Ile His Ala Asp Pro Lys Leu Leu Leu Cys Asn Pro Arg 
            500                 505                 510         


Lys Gln Gly Pro Glu Thr Gln Gly Ser Thr Ala Glu Leu Ile Thr Gly 
        515                 520                 525             


Leu Val Gln Leu Val Pro Gln Ser His Met Pro Glu Ile Ala Gln Glu 
    530                 535                 540                 


Ala Met Glu Ala Leu Leu Val Leu His Gln Leu Asp Ser Ile Asp Leu 
545                 550                 555                 560 


Trp Asn Pro Asp Ala Pro Val Glu Thr Phe Trp Glu Ile Ser Ser Gln 
                565                 570                 575     


Met Leu Phe Tyr Ile Cys Lys Lys Leu Thr Ser His Gln Met Leu Ser 
            580                 585                 590         


Ser Thr Glu Ile Leu Lys Trp Leu Arg Glu Ile Leu Ile Cys Arg Asn 
        595                 600                 605             


Lys Phe Leu Leu Lys Asn Lys Gln Ala Asp Arg Ser Ser Cys His Phe 
    610                 615                 620                 


Leu Leu Phe Tyr Gly Val Gly Cys Asp Ile Pro Ser Ser Gly Asn Thr 
625                 630                 635                 640 


Ser Gln Met Ser Met Asp His Glu Glu Leu Leu Arg Thr Pro Gly Ala 
                645                 650                 655     


Ser Leu Arg Lys Gly Lys Gly Asn Ser Ser Met Asp Ser Ala Ala Gly 
            660                 665                 670         


Cys Ser Gly Thr Pro Pro Ile Cys Arg Gln Ala Gln Thr Lys Leu Glu 
        675                 680                 685             


Val Ala Leu Tyr Met Phe Leu Trp Asn Pro Asp Thr Glu Ala Val Leu 
    690                 695                 700                 


Val Ala Met Ser Cys Phe Arg His Leu Cys Glu Glu Ala Asp Ile Arg 
705                 710                 715                 720 


Cys Gly Val Asp Glu Val Ser Val His Asn Leu Leu Pro Asn Tyr Asn 
                725                 730                 735     


Thr Phe Met Glu Phe Ala Ser Val Ser Asn Met Met Ser Thr Gly Arg 
            740                 745                 750         


Ala Ala Leu Gln Lys Arg Val Met Ala Leu Leu Arg Arg Ile Glu His 
        755                 760                 765             


Pro Thr Ala Gly Asn Thr Glu Ala Trp Glu Asp Thr His Ala Lys Trp 
    770                 775                 780                 


Glu Gln Ala Thr Lys Leu Ile Leu Asn Tyr Pro Lys Ala Lys Met Glu 
785                 790                 795                 800 


Asp Gly Gln Ala Ala Glu Ser Leu His Lys Thr Ile Val Lys Arg Arg 
                805                 810                 815     


Met Ser His Val Ser Gly Gly Gly Ser Ile Asp Leu Ser Asp Thr Asp 
            820                 825                 830         


Ser Leu Gln Glu Trp Ile Asn Met Thr Gly Phe Leu Cys Ala Leu Gly 
        835                 840                 845             


Gly Val Cys Leu Gln Gln Arg Ser Asn Ser Gly Leu Ala Thr Tyr Ser 
    850                 855                 860                 


Pro Pro Met Gly Pro Val Ser Glu Arg Lys Gly Ser Met Ile Ser Val 
865                 870                 875                 880 


Met Ser Ser Glu Gly Asn Ala Asp Thr Pro Val Ser Lys Phe Met Asp 
                885                 890                 895     


Arg Leu Leu Ser Leu Met Val Cys Asn His Glu Lys Val Gly Leu Gln 
            900                 905                 910         


Ile Arg Thr Asn Val Lys Asp Leu Val Gly Leu Glu Leu Ser Pro Ala 
        915                 920                 925             


Leu Tyr Pro Met Leu Phe Asn Lys Leu Lys Asn Thr Ile Ser Lys Phe 
    930                 935                 940                 


Phe Asp Ser Gln Gly Gln Val Leu Leu Thr Asp Thr Asn Thr Gln Phe 
945                 950                 955                 960 


Val Glu Gln Thr Ile Ala Ile Met Lys Asn Leu Leu Asp Asn His Thr 
                965                 970                 975     


Glu Gly Ser Ser Glu His Leu Gly Gln Ala Ser Ile Glu Thr Met Met 
            980                 985                 990         


Leu Asn Leu Val Arg Tyr Val Arg  Val Leu Gly Asn Met  Val His Ala 
        995                 1000                 1005             


Ile Gln  Ile Lys Thr Lys Leu  Cys Gln Leu Val Glu  Val Met Met 
    1010                 1015                 1020             


Ala Arg  Arg Asp Asp Leu Ser  Phe Cys Gln Glu Met  Lys Phe Arg 
    1025                 1030                 1035             


Asn Lys  Met Val Glu Tyr Leu  Thr Asp Trp Val Met  Gly Thr Ser 
    1040                 1045                 1050             


Asn Gln  Ala Ala Asp Asp Asp  Val Lys Cys Leu Thr  Arg Asp Leu 
    1055                 1060                 1065             


Asp Gln  Ala Ser Met Glu Ala  Val Val Ser Leu Leu  Ala Gly Leu 
    1070                 1075                 1080             


Pro Leu  Gln Pro Glu Glu Gly  Asp Gly Val Glu Leu  Met Glu Ala 
    1085                 1090                 1095             


Lys Ser  Gln Leu Phe Leu Lys  Tyr Phe Thr Leu Phe  Met Asn Leu 
    1100                 1105                 1110             


Leu Asn  Asp Cys Ser Glu Val  Glu Asp Glu Ser Ala  Gln Thr Gly 
    1115                 1120                 1125             


Gly Arg  Lys Arg Gly Met Ser  Arg Arg Leu Ala Ser  Leu Arg His 
    1130                 1135                 1140             


Cys Thr  Val Leu Ala Met Ser  Asn Leu Leu Asn Ala  Asn Val Asp 
    1145                 1150                 1155             


Ser Gly  Leu Met His Ser Ile  Gly Leu Gly Tyr His  Lys Asp Leu 
    1160                 1165                 1170             


Gln Thr  Arg Ala Thr Phe Met  Glu Val Leu Thr Lys  Ile Leu Gln 
    1175                 1180                 1185             


Gln Gly  Thr Glu Phe Asp Thr  Leu Ala Glu Thr Val  Leu Ala Asp 
    1190                 1195                 1200             


Arg Phe  Glu Arg Leu Val Glu  Leu Val Thr Met Met  Gly Asp Gln 
    1205                 1210                 1215             


Gly Glu  Leu Pro Ile Ala Met  Ala Leu Ala Asn Val  Val Pro Cys 
    1220                 1225                 1230             


Ser Gln  Trp Asp Glu Leu Ala  Arg Val Leu Val Thr  Leu Phe Asp 
    1235                 1240                 1245             


Ser Arg  His Leu Leu Tyr Gln  Leu Leu Trp Asn Met  Phe Ser Lys 
    1250                 1255                 1260             


Glu Val  Glu Leu Ala Asp Ser  Met Gln Thr Leu Phe  Arg Gly Asn 
    1265                 1270                 1275             


Ser Leu  Ala Ser Lys Ile Met  Thr Phe Cys Phe Lys  Val Tyr Gly 
    1280                 1285                 1290             


Ala Thr  Tyr Leu Gln Lys Leu  Leu Asp Pro Leu Leu  Arg Ile Val 
    1295                 1300                 1305             


Ile Thr  Ser Ser Asp Trp Gln  His Val Ser Phe Glu  Val Asp Pro 
    1310                 1315                 1320             


Thr Arg  Leu Glu Pro Ser Glu  Ser Leu Glu Glu Asn  Gln Arg Asn 
    1325                 1330                 1335             


Leu Leu  Gln Met Thr Glu Lys  Phe Phe His Ala Ile  Ile Ser Ser 
    1340                 1345                 1350             


Ser Ser  Glu Phe Pro Pro Gln  Leu Arg Ser Val Cys  His Cys Leu 
    1355                 1360                 1365             


Tyr Gln  Ala Thr Cys His Ser  Leu Leu Asn Lys Ala  Thr Val Lys 
    1370                 1375                 1380             


Glu Lys  Lys Glu Asn Lys Lys  Ser Val Val Ser Gln  Arg Phe Pro 
    1385                 1390                 1395             


Gln Asn  Ser Ile Gly Ala Val  Gly Ser Ala Met Phe  Leu Arg Phe 
    1400                 1405                 1410             


Ile Asn  Pro Ala Ile Val Ser  Pro Tyr Glu Ala Gly  Ile Leu Asp 
    1415                 1420                 1425             


Lys Lys  Pro Pro Pro Arg Ile  Glu Arg Gly Leu Lys  Leu Met Ser 
    1430                 1435                 1440             


Lys Ile  Leu Gln Ser Ile Ala  Asn His Val Leu Phe  Thr Lys Glu 
    1445                 1450                 1455             


Glu His  Met Arg Pro Phe Asn  Asp Phe Val Lys Ser  Asn Phe Asp 
    1460                 1465                 1470             


Ala Ala  Arg Arg Phe Phe Leu  Asp Ile Ala Ser Asp  Cys Pro Thr 
    1475                 1480                 1485             


Ser Asp  Ala Val Asn His Ser  Leu Ser Phe Ile Ser  Asp Gly Asn 
    1490                 1495                 1500             


Val Leu  Ala Leu His Arg Leu  Leu Trp Asn Asn Gln  Glu Lys Ile 
    1505                 1510                 1515             


Gly Gln  Tyr Leu Ser Ser Asn  Arg Asp His Lys Ala  Val Gly Arg 
    1520                 1525                 1530             


Arg Pro  Phe Asp Lys Met Ala  Thr Leu Leu Ala Tyr  Leu Gly Pro 
    1535                 1540                 1545             


Pro Glu  His Lys Pro Val Ala  Asp Thr His Trp Ser  Ser Leu Asn 
    1550                 1555                 1560             


Leu Thr  Ser Ser Lys Phe Glu  Glu Phe Met Thr Arg  His Gln Val 
    1565                 1570                 1575             


His Glu  Lys Glu Glu Phe Lys  Ala Leu Lys Thr Leu  Ser Ile Phe 
    1580                 1585                 1590             


Tyr Gln  Ala Gly Thr Ser Lys  Ala Gly Asn Pro Ile  Phe Tyr Tyr 
    1595                 1600                 1605             


Val Ala  Arg Arg Phe Lys Thr  Gly Gln Ile Asn Gly  Asp Leu Leu 
    1610                 1615                 1620             


Ile Tyr  His Val Leu Leu Thr  Leu Lys Pro Tyr Tyr  Ala Lys Pro 
    1625                 1630                 1635             


Tyr Glu  Ile Val Val Asp Leu  Thr His Thr Gly Pro  Ser Asn Arg 
    1640                 1645                 1650             


Phe Lys  Thr Asp Phe Leu Ser  Lys Trp Phe Val Val  Phe Pro Gly 
    1655                 1660                 1665             


Phe Ala  Tyr Asp Asn Val Ser  Ala Val Tyr Ile Tyr  Asn Cys Asn 
    1670                 1675                 1680             


Ser Trp  Val Arg Glu Tyr Thr  Lys Tyr His Glu Arg  Leu Leu Thr 
    1685                 1690                 1695             


Gly Leu  Lys Gly Ser Lys Arg  Leu Val Phe Ile Asp  Cys Pro Gly 
    1700                 1705                 1710             


Lys Leu  Ala Glu His Ile Glu  His Glu Gln Gln Lys  Leu Pro Ala 
    1715                 1720                 1725             


Ala Thr  Leu Ala Leu Glu Glu  Asp Leu Lys Val Phe  His Asn Ala 
    1730                 1735                 1740             


Leu Lys  Leu Ala His Lys Asp  Thr Lys Val Ser Ile  Lys Val Gly 
    1745                 1750                 1755             


Ser Thr  Ala Val Gln Val Thr  Ser Ala Glu Arg Thr  Lys Val Leu 
    1760                 1765                 1770             


Gly Gln  Ser Val Phe Leu Asn  Asp Ile Tyr Tyr Ala  Ser Glu Ile 
    1775                 1780                 1785             


Glu Glu  Ile Cys Leu Val Asp  Glu Asn Gln Phe Thr  Leu Thr Ile 
    1790                 1795                 1800             


Ala Asn  Gln Gly Thr Pro Leu  Thr Phe Met His Gln  Glu Cys Glu 
    1805                 1810                 1815             


Ala Ile  Val Gln Ser Ile Ile  His Ile Arg Thr Arg  Trp Glu Leu 
    1820                 1825                 1830             


Ser Gln  Pro Asp Ser Ile Pro  Gln His Thr Lys Ile  Arg Pro Lys 
    1835                 1840                 1845             


Asp Val  Pro Gly Thr Leu Leu  Asn Ile Ala Leu Leu  Asn Leu Gly 
    1850                 1855                 1860             


Ser Ser  Asp Pro Ser Leu Arg  Ser Ala Ala Tyr Asn  Leu Leu Cys 
    1865                 1870                 1875             


Ala Leu  Thr Cys Thr Phe Asn  Leu Lys Ile Glu Gly  Gln Leu Leu 
    1880                 1885                 1890             


Glu Thr  Ser Gly Leu Cys Ile  Pro Ala Asn Asn Thr  Leu Phe Ile 
    1895                 1900                 1905             


Val Ser  Ile Ser Lys Thr Leu  Ala Ala Asn Glu Pro  His Leu Thr 
    1910                 1915                 1920             


Leu Glu  Phe Leu Glu Glu Cys  Ile Ser Gly Phe Ser  Lys Ser Ser 
    1925                 1930                 1935             


Ile Glu  Leu Lys His Leu Cys  Leu Glu Tyr Met Thr  Pro Trp Leu 
    1940                 1945                 1950             


Ser Asn  Leu Val Arg Phe Cys  Lys His Asn Asp Asp  Ala Lys Arg 
    1955                 1960                 1965             


Gln Arg  Val Thr Ala Ile Leu  Asp Lys Leu Ile Thr  Met Thr Ile 
    1970                 1975                 1980             


Asn Glu  Lys Gln Met Tyr Pro  Ser Ile Gln Ala Lys  Ile Trp Gly 
    1985                 1990                 1995             


Ser Leu  Gly Gln Ile Thr Asp  Leu Leu Asp Val Val  Leu Asp Ser 
    2000                 2005                 2010             


Phe Ile  Lys Thr Ser Ala Thr  Gly Gly Leu Gly Ser  Ile Lys Ala 
    2015                 2020                 2025             


Glu Val  Met Ala Asp Thr Ala  Val Ala Leu Ala Ser  Gly Asn Val 
    2030                 2035                 2040             


Lys Leu  Val Ser Ser Lys Val  Ile Gly Arg Met Cys  Lys Ile Ile 
    2045                 2050                 2055             


Asp Lys  Thr Cys Leu Ser Pro  Thr Pro Thr Leu Glu  Gln His Leu 
    2060                 2065                 2070             


Met Trp  Asp Asp Ile Ala Ile  Leu Ala Arg Tyr Met  Leu Met Leu 
    2075                 2080                 2085             


Ser Phe  Asn Asn Ser Leu Asp  Val Ala Ala His Leu  Pro Tyr Leu 
    2090                 2095                 2100             


Phe His  Val Val Thr Phe Leu  Val Ala Thr Gly Pro  Leu Ser Leu 
    2105                 2110                 2115             


Arg Ala  Ser Thr His Gly Leu  Val Ile Asn Ile Ile  His Ser Leu 
    2120                 2125                 2130             


Cys Thr  Cys Ser Gln Leu His  Phe Ser Glu Glu Thr  Lys Gln Val 
    2135                 2140                 2145             


Leu Arg  Leu Ser Leu Thr Glu  Phe Ser Leu Pro Lys  Phe Tyr Leu 
    2150                 2155                 2160             


Leu Phe  Gly Ile Ser Lys Val  Lys Ser Ala Ala Val  Ile Ala Phe 
    2165                 2170                 2175             


Arg Ser  Ser Tyr Arg Asp Arg  Ser Phe Ser Pro Gly  Ser Tyr Glu 
    2180                 2185                 2190             


Arg Glu  Thr Phe Ala Leu Thr  Ser Leu Glu Thr Val  Thr Glu Ala 
    2195                 2200                 2205             


Leu Leu  Glu Ile Met Glu Ala  Cys Met Arg Asp Ile  Pro Thr Cys 
    2210                 2215                 2220             


Lys Trp  Leu Asp Gln Trp Thr  Glu Leu Ala Gln Arg  Phe Ala Phe 
    2225                 2230                 2235             


Gln Tyr  Asn Pro Ser Leu Gln  Pro Arg Ala Leu Val  Val Phe Gly 
    2240                 2245                 2250             


Cys Ile  Ser Lys Arg Val Ser  His Gly Gln Ile Lys  Gln Ile Ile 
    2255                 2260                 2265             


Arg Ile  Leu Ser Lys Ala Leu  Glu Ser Cys Leu Lys  Gly Pro Asp 
    2270                 2275                 2280             


Thr Tyr  Asn Ser Gln Val Leu  Ile Glu Ala Thr Val  Ile Ala Leu 
    2285                 2290                 2295             


Thr Lys  Leu Gln Pro Leu Leu  Asn Lys Asp Ser Pro  Leu His Lys 
    2300                 2305                 2310             


Ala Leu  Phe Trp Val Ala Val  Ala Val Leu Gln Leu  Asp Glu Val 
    2315                 2320                 2325             


Asn Leu  Tyr Ser Ala Gly Thr  Ala Leu Leu Glu Gln  Asn Leu His 
    2330                 2335                 2340             


Thr Leu  Asp Ser Leu Arg Ile  Phe Asn Asp Lys Ser  Pro Glu Glu 
    2345                 2350                 2355             


Val Phe  Met Ala Ile Arg Asn  Pro Leu Glu Trp His  Cys Lys Gln 
    2360                 2365                 2370             


Met Asp  His Phe Val Gly Leu  Asn Phe Asn Ser Asn  Phe Asn Phe 
    2375                 2380                 2385             


Ala Leu  Val Gly His Leu Leu  Lys Gly Tyr Arg His  Pro Ser Pro 
    2390                 2395                 2400             


Ala Ile  Val Ala Arg Thr Val  Arg Ile Leu His Thr  Leu Leu Thr 
    2405                 2410                 2415             


Leu Val  Asn Lys His Arg Asn  Cys Asp Lys Phe Glu  Val Asn Thr 
    2420                 2425                 2430             


Gln Ser  Val Ala Tyr Leu Ala  Ala Leu Leu Thr Val  Ser Glu Glu 
    2435                 2440                 2445             


Val Arg  Ser Arg Cys Ser Leu  Lys His Arg Lys Ser  Leu Leu Leu 
    2450                 2455                 2460             


Thr Asp  Ile Ser Met Glu Asn  Val Pro Met Asp Thr  Tyr Pro Ile 
    2465                 2470                 2475             


His His  Gly Asp Pro Ser Tyr  Arg Thr Leu Lys Glu  Thr Gln Pro 
    2480                 2485                 2490             


Trp Ser  Ser Pro Lys Gly Ser  Glu Gly Tyr Leu Ala  Ala Thr Tyr 
    2495                 2500                 2505             


Pro Thr  Val Gly Gln Thr Ser  Pro Arg Ala Arg Lys  Ser Met Ser 
    2510                 2515                 2520             


Leu Asp  Met Gly Gln Pro Ser  Gln Ala Asn Thr Lys  Lys Leu Leu 
    2525                 2530                 2535             


Gly Thr  Arg Lys Ser Phe Asp  His Leu Ile Ser Asp  Thr Lys Ala 
    2540                 2545                 2550             


Pro Lys  Arg Gln Glu Met Glu  Ser Gly Ile Thr Thr  Pro Pro Lys 
    2555                 2560                 2565             


Met Arg  Arg Val Ala Glu Thr  Asp Tyr Glu Met Glu  Thr Gln Arg 
    2570                 2575                 2580             


Ile Ser  Ser Ser Gln Gln His  Pro His Leu Arg Lys  Val Ser Val 
    2585                 2590                 2595             


Ser Glu  Ser Asn Val Leu Leu  Asp Glu Glu Val Leu  Thr Asp Pro 
    2600                 2605                 2610             


Lys Ile  Gln Ala Leu Leu Leu  Thr Val Leu Ala Thr  Leu Val Lys 
    2615                 2620                 2625             


Tyr Thr  Thr Asp Glu Phe Asp  Gln Arg Ile Leu Tyr  Glu Tyr Leu 
    2630                 2635                 2640             


Ala Glu  Ala Ser Val Val Phe  Pro Lys Val Phe Pro  Val Val His 
    2645                 2650                 2655             


Asn Leu  Leu Asp Ser Lys Ile  Asn Thr Leu Leu Ser  Leu Cys Gln 
    2660                 2665                 2670             


Asp Pro  Asn Leu Leu Asn Pro  Ile His Gly Ile Val  Gln Ser Val 
    2675                 2680                 2685             


Val Tyr  His Glu Glu Ser Pro  Pro Gln Tyr Gln Thr  Ser Tyr Leu 
    2690                 2695                 2700             


Gln Ser  Phe Gly Phe Asn Gly  Leu Trp Arg Phe Ala  Gly Pro Phe 
    2705                 2710                 2715             


Ser Lys  Gln Thr Gln Ile Pro  Asp Tyr Ala Glu Leu  Ile Val Lys 
    2720                 2725                 2730             


Phe Leu  Asp Ala Leu Ile Asp  Thr Tyr Leu Pro Gly  Ile Asp Glu 
    2735                 2740                 2745             


Glu Thr  Ser Glu Glu Ser Leu  Leu Thr Pro Thr Ser  Pro Tyr Pro 
    2750                 2755                 2760             


Pro Ala  Leu Gln Ser Gln Leu  Ser Ile Thr Ala Asn  Leu Asn Leu 
    2765                 2770                 2775             


Ser Asn  Ser Met Thr Ser Leu  Ala Thr Ser Gln His  Ser Pro Gly 
    2780                 2785                 2790             


Ile Asp  Lys Glu Asn Val Glu  Leu Ser Pro Thr Thr  Gly His Cys 
    2795                 2800                 2805             


Asn Ser  Gly Arg Thr Arg His  Gly Ser Ala Ser Gln  Val Gln Lys 
    2810                 2815                 2820             


Gln Arg  Ser Ala Gly Ser Phe  Lys Arg Asn Ser Ile  Lys Lys Ile 
    2825                 2830                 2835             


Val 
    


<210> 572

<400> 572
000


<210> 573

<400> 573
000


<210> 574

<400> 574
000


<210> 575

<400> 575
000


<210> 576

<400> 576
000


<210> 577

<400> 577
000


<210> 578

<400> 578
000


<210> 579

<400> 579
000


<210> 580

<400> 580
000


<210> 581
<211> 848
<212> PRT
<213> Homo sapiens

<400> 581
Met Trp Leu Arg Leu Gly Pro Pro Ser Leu Ser Leu Ser Pro Lys Pro 
1               5                   10                  15      


Thr Val Gly Arg Ser Leu Cys Leu Thr Leu Trp Phe Leu Ser Leu Ala 
            20                  25                  30          


Leu Arg Ala Ser Thr Gln Ala Pro Ala Pro Thr Val Asn Thr His Phe 
        35                  40                  45              


Gly Lys Leu Arg Gly Ala Arg Val Pro Leu Pro Ser Glu Ile Leu Gly 
    50                  55                  60                  


Pro Val Asp Gln Tyr Leu Gly Val Pro Tyr Ala Ala Pro Pro Ile Gly 
65                  70                  75                  80  


Glu Lys Arg Phe Leu Pro Pro Glu Pro Pro Pro Ser Trp Ser Gly Ile 
                85                  90                  95      


Arg Asn Ala Thr His Phe Pro Pro Val Cys Pro Gln Asn Ile His Thr 
            100                 105                 110         


Ala Val Pro Glu Val Met Leu Pro Val Trp Phe Thr Ala Asn Leu Asp 
        115                 120                 125             


Ile Val Ala Thr Tyr Ile Gln Glu Pro Asn Glu Asp Cys Leu Tyr Leu 
    130                 135                 140                 


Asn Val Tyr Val Pro Thr Glu Asp Val Lys Arg Ile Ser Lys Glu Cys 
145                 150                 155                 160 


Ala Arg Lys Pro Asn Lys Lys Ile Cys Arg Lys Gly Gly Ser Gly Ala 
                165                 170                 175     


Lys Lys Gln Gly Glu Asp Leu Ala Asp Asn Asp Gly Asp Glu Asp Glu 
            180                 185                 190         


Asp Ile Arg Asp Ser Gly Ala Lys Pro Val Met Val Tyr Ile His Gly 
        195                 200                 205             


Gly Ser Tyr Met Glu Gly Thr Gly Asn Met Ile Asp Gly Ser Ile Leu 
    210                 215                 220                 


Ala Ser Tyr Gly Asn Val Ile Val Ile Thr Leu Asn Tyr Arg Val Gly 
225                 230                 235                 240 


Val Leu Gly Phe Leu Ser Thr Gly Asp Gln Ala Ala Lys Gly Asn Tyr 
                245                 250                 255     


Gly Leu Leu Asp Gln Ile Gln Ala Leu Arg Trp Val Ser Glu Asn Ile 
            260                 265                 270         


Ala Phe Phe Gly Gly Asp Pro Arg Arg Ile Thr Val Phe Gly Ser Gly 
        275                 280                 285             


Ile Gly Ala Ser Cys Val Ser Leu Leu Thr Leu Ser His His Ser Glu 
    290                 295                 300                 


Gly Leu Phe Gln Arg Ala Ile Ile Gln Ser Gly Ser Ala Leu Ser Ser 
305                 310                 315                 320 


Trp Ala Val Asn Tyr Gln Pro Val Lys Tyr Thr Ser Leu Leu Ala Asp 
                325                 330                 335     


Lys Val Gly Cys Asn Val Leu Asp Thr Val Asp Met Val Asp Cys Leu 
            340                 345                 350         


Arg Gln Lys Ser Ala Lys Glu Leu Val Glu Gln Asp Ile Gln Pro Ala 
        355                 360                 365             


Arg Tyr His Val Ala Phe Gly Pro Val Ile Asp Gly Asp Val Ile Pro 
    370                 375                 380                 


Asp Asp Pro Glu Ile Leu Met Glu Gln Gly Glu Phe Leu Asn Tyr Asp 
385                 390                 395                 400 


Ile Met Leu Gly Val Asn Gln Gly Glu Gly Leu Lys Phe Val Glu Gly 
                405                 410                 415     


Val Val Asp Pro Glu Asp Gly Val Ser Gly Thr Asp Phe Asp Tyr Ser 
            420                 425                 430         


Val Ser Asn Phe Val Asp Asn Leu Tyr Gly Tyr Pro Glu Gly Lys Asp 
        435                 440                 445             


Thr Leu Arg Glu Thr Ile Lys Phe Met Tyr Thr Asp Trp Ala Asp Arg 
    450                 455                 460                 


Asp Asn Pro Glu Thr Arg Arg Lys Thr Leu Val Ala Leu Phe Thr Asp 
465                 470                 475                 480 


His Gln Trp Val Glu Pro Ser Val Val Thr Ala Asp Leu His Ala Arg 
                485                 490                 495     


Tyr Gly Ser Pro Thr Tyr Phe Tyr Ala Phe Tyr His His Cys Gln Ser 
            500                 505                 510         


Leu Met Lys Pro Ala Trp Ser Asp Ala Ala His Gly Asp Glu Val Pro 
        515                 520                 525             


Tyr Val Phe Gly Val Pro Met Val Gly Pro Thr Asp Leu Phe Pro Cys 
    530                 535                 540                 


Asn Phe Ser Lys Asn Asp Val Met Leu Ser Ala Val Val Met Thr Tyr 
545                 550                 555                 560 


Trp Thr Asn Phe Ala Lys Thr Gly Asp Pro Asn Lys Pro Val Pro Gln 
                565                 570                 575     


Asp Thr Lys Phe Ile His Thr Lys Ala Asn Arg Phe Glu Glu Val Ala 
            580                 585                 590         


Trp Ser Lys Tyr Asn Pro Arg Asp Gln Leu Tyr Leu His Ile Gly Leu 
        595                 600                 605             


Lys Pro Arg Val Arg Asp His Tyr Arg Ala Thr Lys Val Ala Phe Trp 
    610                 615                 620                 


Lys His Leu Val Pro His Leu Tyr Asn Leu His Asp Met Phe His Tyr 
625                 630                 635                 640 


Thr Ser Thr Thr Thr Lys Val Pro Pro Pro Asp Thr Thr His Ser Ser 
                645                 650                 655     


His Ile Thr Arg Arg Pro Asn Gly Lys Thr Trp Ser Thr Lys Arg Pro 
            660                 665                 670         


Ala Ile Ser Pro Ala Tyr Ser Asn Glu Asn Ala Gln Gly Ser Trp Asn 
        675                 680                 685             


Gly Asp Gln Asp Ala Gly Pro Leu Leu Val Glu Asn Pro Arg Asp Tyr 
    690                 695                 700                 


Ser Thr Glu Leu Ser Val Thr Ile Ala Val Gly Ala Ser Leu Leu Phe 
705                 710                 715                 720 


Leu Asn Val Leu Ala Phe Ala Ala Leu Tyr Tyr Arg Lys Asp Lys Arg 
                725                 730                 735     


Arg Gln Glu Pro Leu Arg Gln Pro Ser Pro Gln Arg Gly Ala Gly Ala 
            740                 745                 750         


Pro Glu Leu Gly Ala Ala Pro Glu Glu Glu Leu Ala Ala Leu Gln Leu 
        755                 760                 765             


Gly Pro Thr His His Glu Cys Glu Ala Gly Pro Pro His Asp Thr Leu 
    770                 775                 780                 


Arg Leu Thr Ala Leu Pro Asp Tyr Thr Leu Thr Leu Arg Arg Ser Pro 
785                 790                 795                 800 


Asp Asp Ile Pro Leu Met Thr Pro Asn Thr Ile Thr Met Ile Pro Asn 
                805                 810                 815     


Ser Leu Val Gly Leu Gln Thr Leu His Pro Tyr Asn Thr Phe Ala Ala 
            820                 825                 830         


Gly Phe Asn Ser Thr Gly Leu Pro His Ser His Ser Thr Thr Arg Val 
        835                 840                 845             


<210> 582
<211> 816
<212> PRT
<213> Homo sapiens

<400> 582
Met Ser Arg Pro Gln Gly Leu Leu Trp Leu Pro Leu Leu Phe Thr Pro 
1               5                   10                  15      


Val Cys Val Met Leu Asn Ser Asn Val Leu Leu Trp Leu Thr Ala Leu 
            20                  25                  30          


Ala Ile Lys Phe Thr Leu Ile Asp Ser Gln Ala Gln Tyr Pro Val Val 
        35                  40                  45              


Asn Thr Asn Tyr Gly Lys Ile Arg Gly Leu Arg Thr Pro Leu Pro Asn 
    50                  55                  60                  


Glu Ile Leu Gly Pro Val Glu Gln Tyr Leu Gly Val Pro Tyr Ala Ser 
65                  70                  75                  80  


Pro Pro Thr Gly Glu Arg Arg Phe Gln Pro Pro Glu Pro Pro Ser Ser 
                85                  90                  95      


Trp Thr Gly Ile Arg Asn Thr Thr Gln Phe Ala Ala Val Cys Pro Gln 
            100                 105                 110         


His Leu Asp Glu Arg Ser Leu Leu His Asp Met Leu Pro Ile Trp Phe 
        115                 120                 125             


Thr Ala Asn Leu Asp Thr Leu Met Thr Tyr Val Gln Asp Gln Asn Glu 
    130                 135                 140                 


Asp Cys Leu Tyr Leu Asn Ile Tyr Val Pro Thr Glu Asp Asp Ile His 
145                 150                 155                 160 


Asp Gln Asn Ser Lys Lys Pro Val Met Val Tyr Ile His Gly Gly Ser 
                165                 170                 175     


Tyr Met Glu Gly Thr Gly Asn Met Ile Asp Gly Ser Ile Leu Ala Ser 
            180                 185                 190         


Tyr Gly Asn Val Ile Val Ile Thr Ile Asn Tyr Arg Leu Gly Ile Leu 
        195                 200                 205             


Gly Phe Leu Ser Thr Gly Asp Gln Ala Ala Lys Gly Asn Tyr Gly Leu 
    210                 215                 220                 


Leu Asp Gln Ile Gln Ala Leu Arg Trp Ile Glu Glu Asn Val Gly Ala 
225                 230                 235                 240 


Phe Gly Gly Asp Pro Lys Arg Val Thr Ile Phe Gly Ser Gly Ala Gly 
                245                 250                 255     


Ala Ser Cys Val Ser Leu Leu Thr Leu Ser His Tyr Ser Glu Gly Leu 
            260                 265                 270         


Phe Gln Lys Ala Ile Ile Gln Ser Gly Thr Ala Leu Ser Ser Trp Ala 
        275                 280                 285             


Val Asn Tyr Gln Pro Ala Lys Tyr Thr Arg Ile Leu Ala Asp Lys Val 
    290                 295                 300                 


Gly Cys Asn Met Leu Asp Thr Thr Asp Met Val Glu Cys Leu Arg Asn 
305                 310                 315                 320 


Lys Asn Tyr Lys Glu Leu Ile Gln Gln Thr Ile Thr Pro Ala Thr Tyr 
                325                 330                 335     


His Ile Ala Phe Gly Pro Val Ile Asp Gly Asp Val Ile Pro Asp Asp 
            340                 345                 350         


Pro Gln Ile Leu Met Glu Gln Gly Glu Phe Leu Asn Tyr Asp Ile Met 
        355                 360                 365             


Leu Gly Val Asn Gln Gly Glu Gly Leu Lys Phe Val Asp Gly Ile Val 
    370                 375                 380                 


Asp Asn Glu Asp Gly Val Thr Pro Asn Asp Phe Asp Phe Ser Val Ser 
385                 390                 395                 400 


Asn Phe Val Asp Asn Leu Tyr Gly Tyr Pro Glu Gly Lys Asp Thr Leu 
                405                 410                 415     


Arg Glu Thr Ile Lys Phe Met Tyr Thr Asp Trp Ala Asp Lys Glu Asn 
            420                 425                 430         


Pro Glu Thr Arg Arg Lys Thr Leu Val Ala Leu Phe Thr Asp His Gln 
        435                 440                 445             


Trp Val Ala Pro Ala Val Ala Thr Ala Asp Leu His Ala Gln Tyr Gly 
    450                 455                 460                 


Ser Pro Thr Tyr Phe Tyr Ala Phe Tyr His His Cys Gln Ser Glu Met 
465                 470                 475                 480 


Lys Pro Ser Trp Ala Asp Ser Ala His Gly Asp Glu Val Pro Tyr Val 
                485                 490                 495     


Phe Gly Ile Pro Met Ile Gly Pro Thr Glu Leu Phe Ser Cys Asn Phe 
            500                 505                 510         


Ser Lys Asn Asp Val Met Leu Ser Ala Val Val Met Thr Tyr Trp Thr 
        515                 520                 525             


Asn Phe Ala Lys Thr Gly Asp Pro Asn Gln Pro Val Pro Gln Asp Thr 
    530                 535                 540                 


Lys Phe Ile His Thr Lys Pro Asn Arg Phe Glu Glu Val Ala Trp Ser 
545                 550                 555                 560 


Lys Tyr Asn Pro Lys Asp Gln Leu Tyr Leu His Ile Gly Leu Lys Pro 
                565                 570                 575     


Arg Val Arg Asp His Tyr Arg Ala Thr Lys Val Ala Phe Trp Leu Glu 
            580                 585                 590         


Leu Val Pro His Leu His Asn Leu Asn Glu Ile Phe Gln Tyr Val Ser 
        595                 600                 605             


Thr Thr Thr Lys Val Pro Pro Pro Asp Met Thr Ser Phe Pro Tyr Gly 
    610                 615                 620                 


Thr Arg Arg Ser Pro Ala Lys Ile Trp Pro Thr Thr Lys Arg Pro Ala 
625                 630                 635                 640 


Ile Thr Pro Ala Asn Asn Pro Lys His Ser Lys Asp Pro His Lys Thr 
                645                 650                 655     


Gly Pro Glu Asp Thr Thr Val Leu Ile Glu Thr Lys Arg Asp Tyr Ser 
            660                 665                 670         


Thr Glu Leu Ser Val Thr Ile Ala Val Gly Ala Ser Leu Leu Phe Leu 
        675                 680                 685             


Asn Ile Leu Ala Phe Ala Ala Leu Tyr Tyr Lys Lys Asp Lys Arg Arg 
    690                 695                 700                 


His Glu Thr His Arg Arg Pro Ser Pro Gln Arg Asn Thr Thr Asn Asp 
705                 710                 715                 720 


Ile Ala His Ile Gln Asn Glu Glu Ile Met Ser Leu Gln Met Lys Gln 
                725                 730                 735     


Leu Glu His Asp His Glu Cys Glu Ser Leu Gln Ala His Asp Thr Leu 
            740                 745                 750         


Arg Leu Thr Cys Pro Pro Asp Tyr Thr Leu Thr Leu Arg Arg Ser Pro 
        755                 760                 765             


Asp Asp Ile Pro Leu Met Thr Pro Asn Thr Ile Thr Met Ile Pro Asn 
    770                 775                 780                 


Thr Leu Thr Gly Met Gln Pro Leu His Thr Phe Asn Thr Phe Ser Gly 
785                 790                 795                 800 


Gly Gln Asn Ser Thr Asn Leu Pro His Gly His Ser Thr Thr Arg Val 
                805                 810                 815     


<210> 583
<211> 816
<212> PRT
<213> Homo sapiens

<400> 583
Met Leu Arg Pro Gln Gly Leu Leu Trp Leu Pro Leu Leu Phe Thr Ser 
1               5                   10                  15      


Val Cys Val Met Leu Asn Ser Asn Val Leu Leu Trp Ile Thr Ala Leu 
            20                  25                  30          


Ala Ile Lys Phe Thr Leu Ile Asp Ser Gln Ala Gln Tyr Pro Val Val 
        35                  40                  45              


Asn Thr Asn Tyr Gly Lys Ile Gln Gly Leu Arg Thr Pro Leu Pro Ser 
    50                  55                  60                  


Glu Ile Leu Gly Pro Val Glu Gln Tyr Leu Gly Val Pro Tyr Ala Ser 
65                  70                  75                  80  


Pro Pro Thr Gly Glu Arg Arg Phe Gln Pro Pro Glu Ser Pro Ser Ser 
                85                  90                  95      


Trp Thr Gly Ile Arg Asn Ala Thr Gln Phe Ser Ala Val Cys Pro Gln 
            100                 105                 110         


His Leu Asp Glu Arg Phe Leu Leu His Asp Met Leu Pro Ile Trp Phe 
        115                 120                 125             


Thr Thr Ser Leu Asp Thr Leu Met Thr Tyr Val Gln Asp Gln Asn Glu 
    130                 135                 140                 


Asp Cys Leu Tyr Leu Asn Ile Tyr Val Pro Met Glu Asp Asp Ile His 
145                 150                 155                 160 


Glu Gln Asn Ser Lys Lys Pro Val Met Val Tyr Ile His Gly Gly Ser 
                165                 170                 175     


Tyr Met Glu Gly Thr Gly Asn Met Ile Asp Gly Ser Ile Leu Ala Ser 
            180                 185                 190         


Tyr Gly Asn Val Ile Val Ile Thr Ile Asn Tyr Arg Leu Gly Ile Leu 
        195                 200                 205             


Gly Phe Leu Ser Thr Gly Asp Gln Ala Ala Lys Gly Asn Tyr Gly Leu 
    210                 215                 220                 


Leu Asp Gln Ile Gln Ala Leu Arg Trp Ile Glu Glu Asn Val Gly Ala 
225                 230                 235                 240 


Phe Gly Gly Asp Pro Lys Arg Val Thr Ile Phe Gly Ser Gly Ala Gly 
                245                 250                 255     


Ala Ser Cys Val Ser Leu Leu Thr Leu Ser His Tyr Ser Glu Gly Leu 
            260                 265                 270         


Phe Gln Lys Ala Ile Ile Gln Ser Gly Thr Ala Leu Ser Ser Trp Ala 
        275                 280                 285             


Val Asn Tyr Gln Pro Ala Lys Tyr Thr Arg Ile Leu Ala Asp Lys Val 
    290                 295                 300                 


Gly Cys Asn Met Leu Asp Thr Thr Asp Met Val Glu Cys Leu Lys Asn 
305                 310                 315                 320 


Lys Asn Tyr Lys Glu Leu Ile Gln Gln Thr Ile Thr Pro Ala Thr Tyr 
                325                 330                 335     


His Ile Ala Phe Gly Pro Val Ile Asp Gly Asp Val Ile Pro Asp Asp 
            340                 345                 350         


Pro Gln Ile Leu Met Glu Gln Gly Glu Phe Leu Asn Tyr Asp Ile Met 
        355                 360                 365             


Leu Gly Val Asn Gln Gly Glu Gly Leu Lys Phe Val Asp Gly Ile Val 
    370                 375                 380                 


Asp Asn Glu Asp Gly Val Thr Pro Asn Asp Phe Asp Phe Ser Val Ser 
385                 390                 395                 400 


Asn Phe Val Asp Asn Leu Tyr Gly Tyr Pro Glu Gly Lys Asp Thr Leu 
                405                 410                 415     


Arg Glu Thr Ile Lys Phe Met Tyr Thr Asp Trp Ala Asp Lys Glu Asn 
            420                 425                 430         


Pro Glu Thr Arg Arg Lys Thr Leu Val Ala Leu Phe Thr Asp His Gln 
        435                 440                 445             


Trp Val Ala Pro Ala Val Ala Thr Ala Asp Leu His Ala Gln Tyr Gly 
    450                 455                 460                 


Ser Pro Thr Tyr Phe Tyr Ala Phe Tyr His His Cys Gln Ser Glu Met 
465                 470                 475                 480 


Lys Pro Ser Trp Ala Asp Ser Ala His Gly Asp Glu Val Pro Tyr Val 
                485                 490                 495     


Phe Gly Ile Pro Met Ile Gly Pro Thr Glu Leu Phe Ser Cys Asn Phe 
            500                 505                 510         


Ser Lys Asn Asp Val Met Leu Ser Ala Val Val Met Thr Tyr Trp Thr 
        515                 520                 525             


Asn Phe Ala Lys Thr Gly Asp Pro Asn Gln Pro Val Pro Gln Asp Thr 
    530                 535                 540                 


Lys Phe Ile His Thr Lys Pro Asn Arg Phe Glu Glu Val Ala Trp Ser 
545                 550                 555                 560 


Lys Tyr Asn Pro Lys Asp Gln Leu Tyr Leu His Ile Gly Leu Lys Pro 
                565                 570                 575     


Arg Val Arg Asp His Tyr Arg Ala Thr Lys Val Ala Phe Trp Leu Glu 
            580                 585                 590         


Leu Val Pro His Leu His Asn Leu Asn Glu Ile Phe Gln Tyr Val Ser 
        595                 600                 605             


Thr Thr Thr Lys Val Pro Pro Pro Asp Met Thr Ser Phe Pro Tyr Gly 
    610                 615                 620                 


Thr Arg Arg Ser Pro Ala Lys Ile Trp Pro Thr Thr Lys Arg Pro Ala 
625                 630                 635                 640 


Ile Thr Pro Ala Asn Asn Pro Lys His Ser Lys Asp Pro His Lys Thr 
                645                 650                 655     


Gly Pro Glu Asp Thr Thr Val Leu Ile Glu Thr Lys Arg Asp Tyr Ser 
            660                 665                 670         


Thr Glu Leu Ser Val Thr Ile Ala Val Gly Ala Ser Leu Leu Phe Leu 
        675                 680                 685             


Asn Ile Leu Ala Phe Ala Ala Leu Tyr Tyr Lys Lys Asp Lys Arg Arg 
    690                 695                 700                 


His Glu Thr His Arg His Pro Ser Pro Gln Arg Asn Thr Thr Asn Asp 
705                 710                 715                 720 


Ile Thr His Ile Gln Asn Glu Glu Ile Met Ser Leu Gln Met Lys Gln 
                725                 730                 735     


Leu Glu His Asp His Glu Cys Glu Ser Leu Gln Ala His Asp Thr Leu 
            740                 745                 750         


Arg Leu Thr Cys Pro Pro Asp Tyr Thr Leu Thr Leu Arg Arg Ser Pro 
        755                 760                 765             


Asp Asp Ile Pro Phe Met Thr Pro Asn Thr Ile Thr Met Ile Pro Asn 
    770                 775                 780                 


Thr Leu Met Gly Met Gln Pro Leu His Thr Phe Lys Thr Phe Ser Gly 
785                 790                 795                 800 


Gly Gln Asn Ser Thr Asn Leu Pro His Gly His Ser Thr Thr Arg Val 
                805                 810                 815     


<210> 584

<400> 584
000


<210> 585

<400> 585
000


<210> 586

<400> 586
000


<210> 587

<400> 587
000


<210> 588

<400> 588
000


<210> 589

<400> 589
000


<210> 590

<400> 590
000


<210> 591

<400> 591
000


<210> 592

<400> 592
000


<210> 593
<211> 1547
<212> PRT
<213> Homo sapiens

<400> 593
Met Gly Thr Ala Leu Leu Gln Arg Gly Gly Cys Phe Leu Leu Cys Leu 
1               5                   10                  15      


Ser Leu Leu Leu Leu Gly Cys Trp Ala Glu Leu Gly Ser Gly Leu Glu 
            20                  25                  30          


Phe Pro Gly Ala Glu Gly Gln Trp Thr Arg Phe Pro Lys Trp Asn Ala 
        35                  40                  45              


Cys Cys Glu Ser Glu Met Ser Phe Gln Leu Lys Thr Arg Ser Ala Arg 
    50                  55                  60                  


Gly Leu Val Leu Tyr Phe Asp Asp Glu Gly Phe Cys Asp Phe Leu Glu 
65                  70                  75                  80  


Leu Ile Leu Thr Arg Gly Gly Arg Leu Gln Leu Ser Phe Ser Ile Phe 
                85                  90                  95      


Cys Ala Glu Pro Ala Thr Leu Leu Ala Asp Thr Pro Val Asn Asp Gly 
            100                 105                 110         


Ala Trp His Ser Val Arg Ile Arg Arg Gln Phe Arg Asn Thr Thr Leu 
        115                 120                 125             


Phe Ile Asp Gln Val Glu Ala Lys Trp Val Glu Val Lys Ser Lys Arg 
    130                 135                 140                 


Arg Asp Met Thr Val Phe Ser Gly Leu Phe Val Gly Gly Leu Pro Pro 
145                 150                 155                 160 


Glu Leu Arg Ala Ala Ala Leu Lys Leu Thr Leu Ala Ser Val Arg Glu 
                165                 170                 175     


Arg Glu Pro Phe Lys Gly Trp Ile Arg Asp Val Arg Val Asn Ser Ser 
            180                 185                 190         


Gln Val Leu Pro Val Asp Ser Gly Glu Val Lys Leu Asp Asp Glu Pro 
        195                 200                 205             


Pro Asn Ser Gly Gly Gly Ser Pro Cys Glu Ala Gly Glu Glu Gly Glu 
    210                 215                 220                 


Gly Gly Val Cys Leu Asn Gly Gly Val Cys Ser Val Val Asp Asp Gln 
225                 230                 235                 240 


Ala Val Cys Asp Cys Ser Arg Thr Gly Phe Arg Gly Lys Asp Cys Ser 
                245                 250                 255     


Gln Glu Ile Lys Phe Gly Leu Gln Cys Val Leu Pro Val Leu Leu His 
            260                 265                 270         


Asp Asn Asp Gln Gly Lys Tyr Cys Cys Ile Asn Thr Ala Lys Pro Leu 
        275                 280                 285             


Thr Glu Lys Asp Asn Asn Val Glu Gly Leu Ala His Leu Met Met Gly 
    290                 295                 300                 


Asp Gln Gly Lys Ser Lys Gly Lys Glu Glu Tyr Ile Ala Thr Phe Lys 
305                 310                 315                 320 


Gly Ser Glu Tyr Phe Cys Tyr Asp Leu Ser Gln Asn Pro Ile Gln Ser 
                325                 330                 335     


Ser Ser Asp Glu Ile Thr Leu Ser Phe Lys Thr Leu Gln Arg Asn Gly 
            340                 345                 350         


Leu Met Leu His Thr Gly Lys Ser Ala Asp Tyr Val Asn Leu Ala Leu 
        355                 360                 365             


Lys Asn Gly Ala Val Ser Leu Val Ile Asn Leu Gly Ser Gly Ala Phe 
    370                 375                 380                 


Glu Ala Leu Val Glu Pro Val Asn Gly Lys Phe Asn Asp Asn Ala Trp 
385                 390                 395                 400 


His Asp Val Lys Val Thr Arg Asn Leu Arg Gln His Ser Gly Ile Gly 
                405                 410                 415     


His Ala Met Val Asn Lys Leu His Cys Ser Val Thr Ile Ser Val Asp 
            420                 425                 430         


Gly Ile Leu Thr Thr Thr Gly Tyr Thr Gln Glu Asp Tyr Thr Met Leu 
        435                 440                 445             


Gly Ser Asp Asp Phe Phe Tyr Val Gly Gly Ser Pro Ser Thr Ala Asp 
    450                 455                 460                 


Leu Pro Gly Ser Pro Val Ser Asn Asn Phe Met Gly Cys Leu Lys Glu 
465                 470                 475                 480 


Val Val Tyr Lys Asn Asn Asp Val Arg Leu Glu Leu Ser Arg Leu Ala 
                485                 490                 495     


Lys Gln Gly Asp Pro Lys Met Lys Ile His Gly Val Val Ala Phe Lys 
            500                 505                 510         


Cys Glu Asn Val Ala Thr Leu Asp Pro Ile Thr Phe Glu Thr Pro Glu 
        515                 520                 525             


Ser Phe Ile Ser Leu Pro Lys Trp Asn Ala Lys Lys Thr Gly Ser Ile 
    530                 535                 540                 


Ser Phe Asp Phe Arg Thr Thr Glu Pro Asn Gly Leu Ile Leu Phe Ser 
545                 550                 555                 560 


His Gly Lys Pro Arg His Gln Lys Asp Ala Lys His Pro Gln Met Ile 
                565                 570                 575     


Lys Val Asp Phe Phe Ala Ile Glu Met Leu Asp Gly His Leu Tyr Leu 
            580                 585                 590         


Leu Leu Asp Met Gly Ser Gly Thr Ile Lys Ile Lys Ala Leu Leu Lys 
        595                 600                 605             


Lys Val Asn Asp Gly Glu Trp Tyr His Val Asp Phe Gln Arg Asp Gly 
    610                 615                 620                 


Arg Ser Gly Thr Ile Ser Val Asn Thr Leu Arg Thr Pro Tyr Thr Ala 
625                 630                 635                 640 


Pro Gly Glu Ser Glu Ile Leu Asp Leu Asp Asp Glu Leu Tyr Leu Gly 
                645                 650                 655     


Gly Leu Pro Glu Asn Lys Ala Gly Leu Val Phe Pro Thr Glu Val Trp 
            660                 665                 670         


Thr Ala Leu Leu Asn Tyr Gly Tyr Val Gly Cys Ile Arg Asp Leu Phe 
        675                 680                 685             


Ile Asp Gly Gln Ser Lys Asp Ile Arg Gln Met Ala Glu Val Gln Ser 
    690                 695                 700                 


Thr Ala Gly Val Lys Pro Ser Cys Ser Lys Glu Thr Ala Lys Pro Cys 
705                 710                 715                 720 


Leu Ser Asn Pro Cys Lys Asn Asn Gly Met Cys Arg Asp Gly Trp Asn 
                725                 730                 735     


Arg Tyr Val Cys Asp Cys Ser Gly Thr Gly Tyr Leu Gly Arg Ser Cys 
            740                 745                 750         


Glu Arg Glu Ala Thr Val Leu Ser Tyr Asp Gly Ser Met Phe Met Lys 
        755                 760                 765             


Ile Gln Leu Pro Val Val Met His Thr Glu Ala Glu Asp Val Ser Leu 
    770                 775                 780                 


Arg Phe Arg Ser Gln Arg Ala Tyr Gly Ile Leu Met Ala Thr Thr Ser 
785                 790                 795                 800 


Arg Asp Ser Ala Asp Thr Leu Arg Leu Glu Leu Asp Ala Gly Arg Val 
                805                 810                 815     


Lys Leu Thr Val Asn Leu Asp Cys Ile Arg Ile Asn Cys Asn Ser Ser 
            820                 825                 830         


Lys Gly Pro Glu Thr Leu Phe Ala Gly Tyr Asn Leu Asn Asp Asn Glu 
        835                 840                 845             


Trp His Thr Val Arg Val Val Arg Arg Gly Lys Ser Leu Lys Leu Thr 
    850                 855                 860                 


Val Asp Asp Gln Gln Ala Met Thr Gly Gln Met Ala Gly Asp His Thr 
865                 870                 875                 880 


Arg Leu Glu Phe His Asn Ile Glu Thr Gly Ile Ile Thr Glu Arg Arg 
                885                 890                 895     


Tyr Leu Ser Ser Val Pro Ser Asn Phe Ile Gly His Leu Gln Ser Leu 
            900                 905                 910         


Thr Phe Asn Gly Met Ala Tyr Ile Asp Leu Cys Lys Asn Gly Asp Ile 
        915                 920                 925             


Asp Tyr Cys Glu Leu Asn Ala Arg Phe Gly Phe Arg Asn Ile Ile Ala 
    930                 935                 940                 


Asp Pro Val Thr Phe Lys Thr Lys Ser Ser Tyr Val Ala Leu Ala Thr 
945                 950                 955                 960 


Leu Gln Ala Tyr Thr Ser Met His Leu Phe Phe Gln Phe Lys Thr Thr 
                965                 970                 975     


Ser Leu Asp Gly Leu Ile Leu Tyr Asn Ser Gly Asp Gly Asn Asp Phe 
            980                 985                 990         


Ile Val Val Glu Leu Val Lys Gly  Tyr Leu His Tyr Val  Phe Asp Leu 
        995                 1000                 1005             


Gly Asn  Gly Ala Asn Leu Ile  Lys Gly Ser Ser Asn  Lys Pro Leu 
    1010                 1015                 1020             


Asn Asp  Asn Gln Trp His Asn  Val Met Ile Ser Arg  Asp Thr Ser 
    1025                 1030                 1035             


Asn Leu  His Thr Val Lys Ile  Asp Thr Lys Ile Thr  Thr Gln Ile 
    1040                 1045                 1050             


Thr Ala  Gly Ala Arg Asn Leu  Asp Leu Lys Ser Asp  Leu Tyr Ile 
    1055                 1060                 1065             


Gly Gly  Val Ala Lys Glu Thr  Tyr Lys Ser Leu Pro  Lys Leu Val 
    1070                 1075                 1080             


His Ala  Lys Glu Gly Phe Gln  Gly Cys Leu Ala Ser  Val Asp Leu 
    1085                 1090                 1095             


Asn Gly  Arg Leu Pro Asp Leu  Ile Ser Asp Ala Leu  Phe Cys Asn 
    1100                 1105                 1110             


Gly Gln  Ile Glu Arg Gly Cys  Glu Gly Pro Ser Thr  Thr Cys Gln 
    1115                 1120                 1125             


Glu Asp  Ser Cys Ser Asn Gln  Gly Val Cys Leu Gln  Gln Trp Asp 
    1130                 1135                 1140             


Gly Phe  Ser Cys Asp Cys Ser  Met Thr Ser Phe Ser  Gly Pro Leu 
    1145                 1150                 1155             


Cys Asn  Asp Pro Gly Thr Thr  Tyr Ile Phe Ser Lys  Gly Gly Gly 
    1160                 1165                 1170             


Gln Ile  Thr Tyr Lys Trp Pro  Pro Asn Asp Arg Pro  Ser Thr Arg 
    1175                 1180                 1185             


Ala Asp  Arg Leu Ala Ile Gly  Phe Ser Thr Val Gln  Lys Glu Ala 
    1190                 1195                 1200             


Val Leu  Val Arg Val Asp Ser  Ser Ser Gly Leu Gly  Asp Tyr Leu 
    1205                 1210                 1215             


Glu Leu  His Ile His Gln Gly  Lys Ile Gly Val Lys  Phe Asn Val 
    1220                 1225                 1230             


Gly Thr  Asp Asp Ile Ala Ile  Glu Glu Ser Asn Ala  Ile Ile Asn 
    1235                 1240                 1245             


Asp Gly  Lys Tyr His Val Val  Arg Phe Thr Arg Ser  Gly Gly Asn 
    1250                 1255                 1260             


Ala Thr  Leu Gln Val Asp Ser  Trp Pro Val Ile Glu  Arg Tyr Pro 
    1265                 1270                 1275             


Ala Gly  Asn Asn Asp Asn Glu  Arg Leu Ala Ile Ala  Arg Gln Arg 
    1280                 1285                 1290             


Ile Pro  Tyr Arg Leu Gly Arg  Val Val Asp Glu Trp  Leu Leu Asp 
    1295                 1300                 1305             


Lys Gly  Arg Gln Leu Thr Ile  Phe Asn Ser Gln Ala  Thr Ile Ile 
    1310                 1315                 1320             


Ile Gly  Gly Lys Glu Gln Gly  Gln Pro Phe Gln Gly  Gln Leu Ser 
    1325                 1330                 1335             


Gly Leu  Tyr Tyr Asn Gly Leu  Lys Val Leu Asn Met  Ala Ala Glu 
    1340                 1345                 1350             


Asn Asp  Ala Asn Ile Ala Ile  Val Gly Asn Val Arg  Leu Val Gly 
    1355                 1360                 1365             


Glu Val  Pro Ser Ser Met Thr  Thr Glu Ser Thr Ala  Thr Ala Met 
    1370                 1375                 1380             


Gln Ser  Glu Met Ser Thr Ser  Ile Met Glu Thr Thr  Thr Thr Leu 
    1385                 1390                 1395             


Ala Thr  Ser Thr Ala Arg Arg  Gly Lys Pro Pro Thr  Lys Glu Pro 
    1400                 1405                 1410             


Ile Ser  Gln Thr Thr Asp Asp  Ile Leu Val Ala Ser  Ala Glu Cys 
    1415                 1420                 1425             


Pro Ser  Asp Asp Glu Asp Ile  Asp Pro Cys Glu Pro  Ser Ser Gly 
    1430                 1435                 1440             


Gly Leu  Ala Asn Pro Thr Arg  Ala Gly Gly Arg Glu  Pro Tyr Pro 
    1445                 1450                 1455             


Gly Ser  Ala Glu Val Ile Arg  Glu Ser Ser Ser Thr  Thr Gly Met 
    1460                 1465                 1470             


Val Val  Gly Ile Val Ala Ala  Ala Ala Leu Cys Ile  Leu Ile Leu 
    1475                 1480                 1485             


Leu Tyr  Ala Met Tyr Lys Tyr  Arg Asn Arg Asp Glu  Gly Ser Tyr 
    1490                 1495                 1500             


His Val  Asp Glu Ser Arg Asn  Tyr Ile Ser Asn Ser  Ala Gln Ser 
    1505                 1510                 1515             


Asn Gly  Ala Val Val Lys Glu  Lys Gln Pro Ser Ser  Ala Lys Ser 
    1520                 1525                 1530             


Ser Asn  Lys Asn Lys Lys Asn  Lys Asp Lys Glu Tyr  Tyr Val 
    1535                 1540                 1545         


<210> 594
<211> 1712
<212> PRT
<213> Homo sapiens

<400> 594
Met Ala Ser Gly Ser Arg Trp Arg Pro Thr Pro Pro Pro Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ala Leu Ala Ala Arg Ala Asp Gly Leu Glu Phe Gly 
            20                  25                  30          


Gly Gly Pro Gly Gln Trp Ala Arg Tyr Ala Arg Trp Ala Gly Ala Ala 
        35                  40                  45              


Ser Ser Gly Glu Leu Ser Phe Ser Leu Arg Thr Asn Ala Thr Arg Ala 
    50                  55                  60                  


Leu Leu Leu Tyr Leu Asp Asp Gly Gly Asp Cys Asp Phe Leu Glu Leu 
65                  70                  75                  80  


Leu Leu Val Asp Gly Arg Leu Arg Leu Arg Phe Thr Leu Ser Cys Ala 
                85                  90                  95      


Glu Pro Ala Thr Leu Gln Leu Asp Thr Pro Val Ala Asp Asp Arg Trp 
            100                 105                 110         


His Met Val Leu Leu Thr Arg Asp Ala Arg Arg Thr Ala Leu Ala Val 
        115                 120                 125             


Asp Gly Glu Ala Arg Ala Ala Glu Val Arg Ser Lys Arg Arg Glu Met 
    130                 135                 140                 


Gln Val Ala Ser Asp Leu Phe Val Gly Gly Ile Pro Pro Asp Val Arg 
145                 150                 155                 160 


Leu Ser Ala Leu Thr Leu Ser Thr Val Lys Tyr Glu Pro Pro Phe Arg 
                165                 170                 175     


Gly Leu Leu Ala Asn Leu Lys Leu Gly Glu Arg Pro Pro Ala Leu Leu 
            180                 185                 190         


Gly Ser Gln Gly Leu Arg Gly Ala Thr Ala Asp Pro Leu Cys Ala Pro 
        195                 200                 205             


Ala Arg Asn Pro Cys Ala Asn Gly Gly Leu Cys Thr Val Leu Ala Pro 
    210                 215                 220                 


Gly Glu Val Gly Cys Asp Cys Ser His Thr Gly Phe Gly Gly Lys Phe 
225                 230                 235                 240 


Cys Ser Glu Glu Glu His Pro Met Glu Gly Pro Ala His Leu Thr Leu 
                245                 250                 255     


Asn Ser Glu Val Gly Ser Leu Leu Phe Ser Glu Gly Gly Ala Gly Arg 
            260                 265                 270         


Gly Gly Ala Gly Asp Val His Gln Pro Thr Lys Gly Lys Glu Glu Phe 
        275                 280                 285             


Val Ala Thr Phe Lys Gly Asn Glu Phe Phe Cys Tyr Asp Leu Ser His 
    290                 295                 300                 


Asn Pro Ile Gln Ser Ser Thr Asp Glu Ile Thr Leu Ala Phe Arg Thr 
305                 310                 315                 320 


Leu Gln Arg Asn Gly Leu Met Leu His Thr Gly Lys Ser Ala Asp Tyr 
                325                 330                 335     


Val Asn Leu Ser Leu Lys Ser Gly Ala Val Trp Leu Val Ile Asn Leu 
            340                 345                 350         


Gly Ser Gly Ala Phe Glu Ala Leu Val Glu Pro Val Asn Gly Lys Phe 
        355                 360                 365             


Asn Asp Asn Ala Trp His Asp Val Arg Val Thr Arg Asn Leu Arg Gln 
    370                 375                 380                 


His Ala Gly Ile Gly His Ala Met Val Asn Lys Leu His Tyr Leu Val 
385                 390                 395                 400 


Thr Ile Ser Val Asp Gly Ile Leu Thr Thr Thr Gly Tyr Thr Gln Glu 
                405                 410                 415     


Asp Tyr Thr Met Leu Gly Ser Asp Asp Phe Phe Tyr Ile Gly Gly Ser 
            420                 425                 430         


Pro Asn Thr Ala Asp Leu Pro Gly Ser Pro Val Ser Asn Asn Phe Met 
        435                 440                 445             


Gly Cys Leu Lys Asp Val Val Tyr Lys Asn Asn Asp Phe Lys Leu Glu 
    450                 455                 460                 


Leu Ser Arg Leu Ala Lys Glu Gly Asp Pro Lys Met Lys Leu Gln Gly 
465                 470                 475                 480 


Asp Leu Ser Phe Arg Cys Glu Asp Val Ala Ala Leu Asp Pro Val Thr 
                485                 490                 495     


Phe Glu Ser Pro Glu Ala Phe Val Ala Leu Pro Arg Trp Ser Ala Lys 
            500                 505                 510         


Arg Thr Gly Ser Ile Ser Leu Asp Phe Arg Thr Thr Glu Pro Asn Gly 
        515                 520                 525             


Leu Leu Leu Phe Ser Gln Gly Arg Arg Ala Gly Gly Gly Ala Gly Ser 
    530                 535                 540                 


His Ser Ser Ala Gln Arg Ala Asp Tyr Phe Ala Met Glu Leu Leu Asp 
545                 550                 555                 560 


Gly His Leu Tyr Leu Leu Leu Asp Met Gly Ser Gly Gly Ile Lys Leu 
                565                 570                 575     


Arg Ala Ser Ser Arg Lys Val Asn Asp Gly Glu Trp Cys His Val Asp 
            580                 585                 590         


Phe Gln Arg Asp Gly Arg Lys Gly Ser Ile Ser Val Asn Ser Arg Ser 
        595                 600                 605             


Thr Pro Phe Leu Ala Thr Gly Asp Ser Glu Ile Leu Asp Leu Glu Ser 
    610                 615                 620                 


Glu Leu Tyr Leu Gly Gly Leu Pro Glu Gly Gly Arg Val Asp Leu Pro 
625                 630                 635                 640 


Leu Pro Pro Glu Val Trp Thr Ala Ala Leu Arg Ala Gly Tyr Val Gly 
                645                 650                 655     


Cys Val Arg Asp Leu Phe Ile Asp Gly Arg Ser Arg Asp Leu Arg Gly 
            660                 665                 670         


Leu Ala Glu Ala Gln Gly Ala Val Gly Val Ala Pro Phe Cys Ser Arg 
        675                 680                 685             


Glu Thr Leu Lys Gln Cys Ala Ser Ala Pro Cys Arg Asn Gly Gly Val 
    690                 695                 700                 


Cys Arg Glu Gly Trp Asn Arg Phe Ile Cys Asp Cys Ile Gly Thr Gly 
705                 710                 715                 720 


Phe Leu Gly Arg Val Cys Glu Arg Glu Ala Thr Val Leu Ser Tyr Asp 
                725                 730                 735     


Gly Ser Met Tyr Met Lys Ile Met Leu Pro Asn Ala Met His Thr Glu 
            740                 745                 750         


Ala Glu Asp Val Ser Leu Arg Phe Met Ser Gln Arg Ala Tyr Gly Leu 
        755                 760                 765             


Met Met Ala Thr Thr Ser Arg Glu Ser Ala Asp Thr Leu Arg Leu Glu 
    770                 775                 780                 


Leu Asp Gly Gly Gln Met Lys Leu Thr Val Asn Leu Asp Cys Leu Arg 
785                 790                 795                 800 


Val Gly Cys Ala Pro Ser Lys Gly Pro Glu Thr Leu Phe Ala Gly His 
                805                 810                 815     


Lys Leu Asn Asp Asn Glu Trp His Thr Val Arg Val Val Arg Arg Gly 
            820                 825                 830         


Lys Ser Leu Gln Leu Ser Val Asp Asn Val Thr Val Glu Gly Gln Met 
        835                 840                 845             


Ala Gly Ala His Met Arg Leu Glu Phe His Asn Ile Glu Thr Gly Ile 
    850                 855                 860                 


Met Thr Glu Arg Arg Phe Ile Ser Val Val Pro Ser Asn Phe Ile Gly 
865                 870                 875                 880 


His Leu Ser Gly Leu Val Phe Asn Gly Gln Pro Tyr Met Asp Gln Cys 
                885                 890                 895     


Lys Asp Gly Asp Ile Thr Tyr Cys Glu Leu Asn Ala Arg Phe Gly Leu 
            900                 905                 910         


Arg Ala Ile Val Ala Asp Pro Val Thr Phe Lys Ser Arg Ser Ser Tyr 
        915                 920                 925             


Leu Ala Leu Ala Thr Leu Gln Ala Tyr Ala Ser Met His Leu Phe Phe 
    930                 935                 940                 


Gln Phe Lys Thr Thr Ala Pro Asp Gly Leu Leu Leu Phe Asn Ser Gly 
945                 950                 955                 960 


Asn Gly Asn Asp Phe Ile Val Ile Glu Leu Val Lys Gly Tyr Ile His 
                965                 970                 975     


Tyr Val Phe Asp Leu Gly Asn Gly Pro Ser Leu Met Lys Gly Asn Ser 
            980                 985                 990         


Asp Lys Pro Val Asn Asp Asn Gln  Trp His Asn Val Val  Val Ser Arg 
        995                 1000                 1005             


Asp Pro  Gly Asn Val His Thr  Leu Lys Ile Asp Ser  Arg Thr Val 
    1010                 1015                 1020             


Thr Gln  His Ser Asn Gly Ala  Arg Asn Leu Asp Leu  Lys Gly Glu 
    1025                 1030                 1035             


Leu Tyr  Ile Gly Gly Leu Ser  Lys Asn Met Phe Ser  Asn Leu Pro 
    1040                 1045                 1050             


Lys Leu  Val Ala Ser Arg Asp  Gly Phe Gln Gly Cys  Leu Ala Ser 
    1055                 1060                 1065             


Val Asp  Leu Asn Gly Arg Leu  Pro Asp Leu Ile Ala  Asp Ala Leu 
    1070                 1075                 1080             


His Arg  Ile Gly Gln Val Glu  Arg Gly Cys Asp Gly  Pro Ser Thr 
    1085                 1090                 1095             


Thr Cys  Thr Glu Glu Ser Cys  Ala Asn Gln Gly Val  Cys Leu Gln 
    1100                 1105                 1110             


Gln Trp  Asp Gly Phe Thr Cys  Asp Cys Thr Met Thr  Ser Tyr Gly 
    1115                 1120                 1125             


Gly Pro  Val Cys Asn Asp Pro  Gly Thr Thr Tyr Ile  Phe Gly Lys 
    1130                 1135                 1140             


Gly Gly  Ala Leu Ile Thr Tyr  Thr Trp Pro Pro Asn  Asp Arg Pro 
    1145                 1150                 1155             


Ser Thr  Arg Met Asp Arg Leu  Ala Val Gly Phe Ser  Thr His Gln 
    1160                 1165                 1170             


Arg Ser  Ala Val Leu Val Arg  Val Asp Ser Ala Ser  Gly Leu Gly 
    1175                 1180                 1185             


Asp Tyr  Leu Gln Leu His Ile  Asp Gln Gly Thr Val  Gly Val Ile 
    1190                 1195                 1200             


Phe Asn  Val Gly Thr Asp Asp  Ile Thr Ile Asp Glu  Pro Asn Ala 
    1205                 1210                 1215             


Ile Val  Ser Asp Gly Lys Tyr  His Val Val Arg Phe  Thr Arg Ser 
    1220                 1225                 1230             


Gly Gly  Asn Ala Thr Leu Gln  Val Asp Ser Trp Pro  Val Asn Glu 
    1235                 1240                 1245             


Arg Tyr  Pro Ala Gly Asn Phe  Asp Asn Glu Arg Leu  Ala Ile Ala 
    1250                 1255                 1260             


Arg Gln  Arg Ile Pro Tyr Arg  Leu Gly Arg Val Val  Asp Glu Trp 
    1265                 1270                 1275             


Leu Leu  Asp Lys Gly Arg Gln  Leu Thr Ile Phe Asn  Ser Gln Ala 
    1280                 1285                 1290             


Ala Ile  Lys Ile Gly Gly Arg  Asp Gln Gly Arg Pro  Phe Gln Gly 
    1295                 1300                 1305             


Gln Val  Ser Gly Leu Tyr Tyr  Asn Gly Leu Lys Val  Leu Ala Leu 
    1310                 1315                 1320             


Ala Ala  Glu Ser Asp Pro Asn  Val Arg Thr Glu Gly  His Leu Arg 
    1325                 1330                 1335             


Leu Val  Gly Glu Gly Pro Ser  Val Leu Leu Ser Ala  Glu Thr Thr 
    1340                 1345                 1350             


Ala Thr  Thr Leu Leu Ala Asp  Met Ala Thr Thr Ile  Met Glu Thr 
    1355                 1360                 1365             


Thr Thr  Thr Met Ala Thr Thr  Thr Thr Arg Arg Gly  Arg Ser Pro 
    1370                 1375                 1380             


Thr Leu  Arg Asp Ser Thr Thr  Gln Asn Thr Asp Asp  Leu Leu Val 
    1385                 1390                 1395             


Ala Ser  Ala Glu Cys Pro Ser  Asp Asp Glu Asp Leu  Glu Glu Cys 
    1400                 1405                 1410             


Glu Pro  Ser Thr Gly Gly Glu  Leu Ile Leu Pro Ile  Ile Thr Glu 
    1415                 1420                 1425             


Asp Ser  Leu Asp Pro Pro Pro  Val Ala Thr Arg Ser  Pro Phe Val 
    1430                 1435                 1440             


Pro Pro  Pro Pro Thr Phe Tyr  Pro Phe Leu Thr Gly  Val Gly Ala 
    1445                 1450                 1455             


Thr Gln  Asp Thr Leu Pro Pro  Pro Ala Ala Arg Arg  Pro Pro Ser 
    1460                 1465                 1470             


Gly Gly  Pro Cys Gln Ala Glu  Arg Asp Asp Ser Asp  Cys Glu Glu 
    1475                 1480                 1485             


Pro Ile  Glu Ala Ser Gly Phe  Ala Ser Gly Glu Val  Phe Asp Ser 
    1490                 1495                 1500             


Ser Leu  Pro Pro Thr Asp Asp  Glu Asp Phe Tyr Thr  Thr Phe Pro 
    1505                 1510                 1515             


Leu Val  Thr Asp Arg Thr Thr  Leu Leu Ser Pro Arg  Lys Pro Ala 
    1520                 1525                 1530             


Pro Arg  Pro Asn Leu Arg Thr  Asp Gly Ala Thr Gly  Ala Pro Gly 
    1535                 1540                 1545             


Val Leu  Phe Ala Pro Ser Ala  Pro Ala Pro Asn Leu  Pro Ala Gly 
    1550                 1555                 1560             


Lys Met  Asn His Arg Asp Pro  Leu Gln Pro Leu Leu  Glu Asn Pro 
    1565                 1570                 1575             


Pro Leu  Gly Pro Gly Ala Pro  Thr Ser Phe Glu Pro  Arg Arg Pro 
    1580                 1585                 1590             


Pro Pro  Leu Arg Pro Gly Val  Thr Ser Ala Pro Gly  Phe Pro His 
    1595                 1600                 1605             


Leu Pro  Thr Ala Asn Pro Thr  Gly Pro Gly Glu Arg  Gly Pro Pro 
    1610                 1615                 1620             


Gly Ala  Val Glu Val Ile Arg  Glu Ser Ser Ser Thr  Thr Gly Met 
    1625                 1630                 1635             


Val Val  Gly Ile Val Ala Ala  Ala Ala Leu Cys Ile  Leu Ile Leu 
    1640                 1645                 1650             


Leu Tyr  Ala Met Tyr Lys Tyr  Arg Asn Arg Asp Glu  Gly Ser Tyr 
    1655                 1660                 1665             


Gln Val  Asp Gln Ser Arg Asn  Tyr Ile Ser Asn Ser  Ala Gln Ser 
    1670                 1675                 1680             


Asn Gly  Ala Val Val Lys Glu  Lys Ala Pro Ala Ala  Pro Lys Thr 
    1685                 1690                 1695             


Pro Ser  Lys Ala Lys Lys Asn  Lys Asp Lys Glu Tyr  Tyr Val 
    1700                 1705                 1710         


<210> 595
<211> 1061
<212> PRT
<213> Homo sapiens

<400> 595
Met Leu Gly Ser Asp Asp Phe Phe Tyr Val Gly Gly Ser Pro Ser Thr 
1               5                   10                  15      


Ala Asp Leu Pro Gly Ser Pro Val Ser Asn Asn Phe Met Gly Cys Leu 
            20                  25                  30          


Lys Glu Val Val Tyr Lys Asn Asn Asp Ile Arg Leu Glu Leu Ser Arg 
        35                  40                  45              


Leu Ala Arg Ile Ala Asp Thr Lys Met Lys Ile Tyr Gly Glu Val Val 
    50                  55                  60                  


Phe Lys Cys Glu Asn Val Ala Thr Leu Asp Pro Ile Asn Phe Glu Thr 
65                  70                  75                  80  


Pro Glu Ala Tyr Ile Ser Leu Pro Lys Trp Asn Thr Lys Arg Met Gly 
                85                  90                  95      


Ser Ile Ser Phe Asp Phe Arg Thr Thr Glu Pro Asn Gly Leu Ile Leu 
            100                 105                 110         


Phe Thr His Gly Lys Pro Gln Glu Arg Lys Asp Ala Arg Ser Gln Lys 
        115                 120                 125             


Asn Thr Lys Val Asp Phe Phe Ala Val Glu Leu Leu Asp Gly Asn Leu 
    130                 135                 140                 


Tyr Leu Leu Leu Asp Met Gly Ser Gly Thr Ile Lys Val Lys Ala Thr 
145                 150                 155                 160 


Gln Lys Lys Ala Asn Asp Gly Glu Trp Tyr His Val Asp Ile Gln Arg 
                165                 170                 175     


Asp Gly Arg Ser Gly Thr Ile Ser Val Asn Ser Arg Arg Thr Pro Phe 
            180                 185                 190         


Thr Ala Ser Gly Glu Ser Glu Ile Leu Asp Leu Glu Gly Asp Met Tyr 
        195                 200                 205             


Leu Gly Gly Leu Pro Glu Asn Arg Ala Gly Leu Ile Leu Pro Thr Glu 
    210                 215                 220                 


Leu Trp Thr Ala Met Leu Asn Tyr Gly Tyr Val Gly Cys Ile Arg Asp 
225                 230                 235                 240 


Leu Phe Ile Asp Gly Arg Ser Lys Asn Ile Arg Gln Leu Ala Glu Met 
                245                 250                 255     


Gln Asn Ala Ala Gly Val Lys Ser Ser Cys Ser Arg Met Ser Ala Lys 
            260                 265                 270         


Gln Cys Asp Ser Tyr Pro Cys Lys Asn Asn Ala Val Cys Lys Asp Gly 
        275                 280                 285             


Trp Asn Arg Phe Ile Cys Asp Cys Thr Gly Thr Gly Tyr Trp Gly Arg 
    290                 295                 300                 


Thr Cys Glu Arg Glu Ala Ser Ile Leu Ser Tyr Asp Gly Ser Met Tyr 
305                 310                 315                 320 


Met Lys Ile Ile Met Pro Met Val Met His Thr Glu Ala Glu Asp Val 
                325                 330                 335     


Ser Phe Arg Phe Met Ser Gln Arg Ala Tyr Gly Leu Leu Val Ala Thr 
            340                 345                 350         


Thr Ser Arg Asp Ser Ala Asp Thr Leu Arg Leu Glu Leu Asp Gly Gly 
        355                 360                 365             


Arg Val Lys Leu Met Val Asn Leu Asp Cys Ile Arg Ile Asn Cys Asn 
    370                 375                 380                 


Ser Ser Lys Gly Pro Glu Thr Leu Tyr Ala Gly Gln Lys Leu Asn Asp 
385                 390                 395                 400 


Asn Glu Trp His Thr Val Arg Val Val Arg Arg Gly Lys Ser Leu Lys 
                405                 410                 415     


Leu Thr Val Asp Asp Asp Val Ala Glu Gly Thr Met Val Gly Asp His 
            420                 425                 430         


Thr Arg Leu Glu Phe His Asn Ile Glu Thr Gly Ile Met Thr Glu Lys 
        435                 440                 445             


Arg Tyr Ile Ser Val Val Pro Ser Ser Phe Ile Gly His Leu Gln Ser 
    450                 455                 460                 


Leu Met Phe Asn Gly Leu Leu Tyr Ile Asp Leu Cys Lys Asn Gly Asp 
465                 470                 475                 480 


Ile Asp Tyr Cys Glu Leu Lys Ala Arg Phe Gly Leu Arg Asn Ile Ile 
                485                 490                 495     


Ala Asp Pro Val Thr Phe Lys Thr Lys Ser Ser Tyr Leu Ser Leu Ala 
            500                 505                 510         


Thr Leu Gln Ala Tyr Thr Ser Met His Leu Phe Phe Gln Phe Lys Thr 
        515                 520                 525             


Thr Ser Pro Asp Gly Phe Ile Leu Phe Asn Ser Gly Asp Gly Asn Asp 
    530                 535                 540                 


Phe Ile Ala Val Glu Leu Val Lys Gly Tyr Ile His Tyr Val Phe Asp 
545                 550                 555                 560 


Leu Gly Asn Gly Pro Asn Val Ile Lys Gly Asn Ser Asp Arg Pro Leu 
                565                 570                 575     


Asn Asp Asn Gln Trp His Asn Val Val Ile Thr Arg Asp Asn Ser Asn 
            580                 585                 590         


Thr His Ser Leu Lys Val Asp Thr Lys Val Val Thr Gln Val Ile Asn 
        595                 600                 605             


Gly Ala Lys Asn Leu Asp Leu Lys Gly Asp Leu Tyr Met Ala Gly Leu 
    610                 615                 620                 


Ala Gln Gly Met Tyr Ser Asn Leu Pro Lys Leu Val Ala Ser Arg Asp 
625                 630                 635                 640 


Gly Phe Gln Gly Cys Leu Ala Ser Val Asp Leu Asn Gly Arg Leu Pro 
                645                 650                 655     


Asp Leu Ile Asn Asp Ala Leu His Arg Ser Gly Gln Ile Glu Arg Gly 
            660                 665                 670         


Cys Glu Gly Pro Ser Thr Thr Cys Gln Glu Asp Ser Cys Ala Asn Gln 
        675                 680                 685             


Gly Val Cys Met Gln Gln Trp Glu Gly Phe Thr Cys Asp Cys Ser Met 
    690                 695                 700                 


Thr Ser Tyr Ser Gly Asn Gln Cys Asn Asp Pro Gly Ala Thr Tyr Ile 
705                 710                 715                 720 


Phe Gly Lys Ser Gly Gly Leu Ile Leu Tyr Thr Trp Pro Ala Asn Asp 
                725                 730                 735     


Arg Pro Ser Thr Arg Ser Asp Arg Leu Ala Val Gly Phe Ser Thr Thr 
            740                 745                 750         


Val Lys Asp Gly Ile Leu Val Arg Ile Asp Ser Ala Pro Gly Leu Gly 
        755                 760                 765             


Asp Phe Leu Gln Leu His Ile Glu Gln Gly Lys Ile Gly Val Val Phe 
    770                 775                 780                 


Asn Ile Gly Thr Val Asp Ile Ser Ile Lys Glu Glu Arg Thr Pro Val 
785                 790                 795                 800 


Asn Asp Gly Lys Tyr His Val Val Arg Phe Thr Arg Asn Gly Gly Asn 
                805                 810                 815     


Ala Thr Leu Gln Val Asp Asn Trp Pro Val Asn Glu His Tyr Pro Thr 
            820                 825                 830         


Gly Arg Gln Leu Thr Ile Phe Asn Thr Gln Ala Gln Ile Ala Ile Gly 
        835                 840                 845             


Gly Lys Asp Lys Gly Arg Leu Phe Gln Gly Gln Leu Ser Gly Leu Tyr 
    850                 855                 860                 


Tyr Asp Gly Leu Lys Val Leu Asn Met Ala Ala Glu Asn Asn Pro Asn 
865                 870                 875                 880 


Ile Lys Ile Asn Gly Ser Val Arg Leu Val Gly Glu Val Pro Ser Ile 
                885                 890                 895     


Leu Gly Thr Thr Gln Thr Thr Ser Met Pro Pro Glu Met Ser Thr Thr 
            900                 905                 910         


Val Met Glu Thr Thr Thr Thr Met Ala Thr Thr Thr Thr Arg Lys Asn 
        915                 920                 925             


Arg Ser Thr Ala Ser Ile Gln Pro Thr Ser Asp Asp Leu Val Ser Ser 
    930                 935                 940                 


Ala Glu Cys Ser Ser Asp Asp Glu Asp Phe Val Glu Cys Glu Pro Ser 
945                 950                 955                 960 


Thr Ala Asn Pro Thr Glu Pro Gly Ile Arg Arg Val Pro Gly Ala Ser 
                965                 970                 975     


Glu Val Ile Arg Glu Ser Ser Ser Thr Thr Gly Met Val Val Gly Ile 
            980                 985                 990         


Val Ala Ala Ala Ala Leu Cys Ile  Leu Ile Leu Leu Tyr  Ala Met Tyr 
        995                 1000                 1005             


Lys Tyr  Arg Asn Arg Asp Glu  Gly Ser Tyr Gln Val  Asp Glu Thr 
    1010                 1015                 1020             


Arg Asn  Tyr Ile Ser Asn Ser  Ala Gln Ser Asn Gly  Thr Leu Met 
    1025                 1030                 1035             


Lys Glu  Lys Gln Gln Ser Ser  Lys Ser Gly His Lys  Lys Gln Lys 
    1040                 1045                 1050             


Asn Lys  Asp Arg Glu Tyr Tyr  Val 
    1055                 1060     


<210> 596

<400> 596
000


<210> 597

<400> 597
000


<210> 598

<400> 598
000


<210> 599

<400> 599
000


<210> 600

<400> 600
000


<210> 601

<400> 601
000


<210> 602

<400> 602
000


<210> 603

<400> 603
000


<210> 604

<400> 604
000


<210> 605

<400> 605
000


<210> 606

<400> 606
000


<210> 607

<400> 607
000


<210> 608

<400> 608
000


<210> 609

<400> 609
000


<210> 610

<400> 610
000


<210> 611

<400> 611
000


<210> 612

<400> 612
000


<210> 613

<400> 613
000


<210> 614

<400> 614
000


<210> 615

<400> 615
000


<210> 616

<400> 616
000


<210> 617

<400> 617
000


<210> 618

<400> 618
000


<210> 619

<400> 619
000


<210> 620

<400> 620
000


<210> 621

<400> 621
000


<210> 622

<400> 622
000


<210> 623

<400> 623
000


<210> 624

<400> 624
000


<210> 625

<400> 625
000


<210> 626

<400> 626
000


<210> 627

<400> 627
000


<210> 628

<400> 628
000


<210> 629

<400> 629
000


<210> 630

<400> 630
000


<210> 631

<400> 631
000


<210> 632

<400> 632
000


<210> 633

<400> 633
000


<210> 634

<400> 634
000


<210> 635

<400> 635
000


<210> 636

<400> 636
000


<210> 637

<400> 637
000


<210> 638

<400> 638
000


<210> 639

<400> 639
000


<210> 640

<400> 640
000


<210> 641

<400> 641
000


<210> 642

<400> 642
000


<210> 643

<400> 643
000


<210> 644

<400> 644
000


<210> 645

<400> 645
000


<210> 646

<400> 646
000


<210> 647

<400> 647
000


<210> 648

<400> 648
000


<210> 649

<400> 649
000


<210> 650

<400> 650
000


<210> 651

<400> 651
000


<210> 652

<400> 652
000


<210> 653

<400> 653
000


<210> 654

<400> 654
000


<210> 655

<400> 655
000


<210> 656

<400> 656
000


<210> 657

<400> 657
000


<210> 658

<400> 658
000


<210> 659

<400> 659
000


<210> 660

<400> 660
000


<210> 661

<400> 661
000


<210> 662

<400> 662
000


<210> 663

<400> 663
000


<210> 664

<400> 664
000


<210> 665

<400> 665
000


<210> 666

<400> 666
000


<210> 667

<400> 667
000


<210> 668

<400> 668
000


<210> 669

<400> 669
000


<210> 670

<400> 670
000


<210> 671

<400> 671
000


<210> 672

<400> 672
000


<210> 673

<400> 673
000


<210> 674

<400> 674
000


<210> 675

<400> 675
000


<210> 676

<400> 676
000


<210> 677

<400> 677
000


<210> 678

<400> 678
000


<210> 679

<400> 679
000


<210> 680

<400> 680
000


<210> 681

<400> 681
000


<210> 682

<400> 682
000


<210> 683

<400> 683
000


<210> 684

<400> 684
000


<210> 685

<400> 685
000


<210> 686

<400> 686
000


<210> 687

<400> 687
000


<210> 688

<400> 688
000


<210> 689

<400> 689
000


<210> 690

<400> 690
000


<210> 691

<400> 691
000


<210> 692

<400> 692
000


<210> 693

<400> 693
000


<210> 694

<400> 694
000


<210> 695

<400> 695
000


<210> 696

<400> 696
000


<210> 697

<400> 697
000


<210> 698

<400> 698
000


<210> 699

<400> 699
000


<210> 700

<400> 700
000


<210> 701

<400> 701
000


<210> 702

<400> 702
000


<210> 703

<400> 703
000


<210> 704

<400> 704
000


<210> 705

<400> 705
000


<210> 706

<400> 706
000


<210> 707

<400> 707
000


<210> 708

<400> 708
000


<210> 709

<400> 709
000


<210> 710

<400> 710
000


<210> 711

<400> 711
000


<210> 712

<400> 712
000


<210> 713

<400> 713
000


<210> 714

<400> 714
000


<210> 715

<400> 715
000


<210> 716

<400> 716
000


<210> 717

<400> 717
000


<210> 718

<400> 718
000


<210> 719

<400> 719
000


<210> 720

<400> 720
000


<210> 721

<400> 721
000


<210> 722

<400> 722
000


<210> 723

<400> 723
000


<210> 724

<400> 724
000


<210> 725

<400> 725
000


<210> 726

<400> 726
000


<210> 727

<400> 727
000


<210> 728

<400> 728
000


<210> 729

<400> 729
000


<210> 730

<400> 730
000


<210> 731

<400> 731
000


<210> 732

<400> 732
000


<210> 733

<400> 733
000


<210> 734

<400> 734
000


<210> 735

<400> 735
000


<210> 736

<400> 736
000


<210> 737

<400> 737
000


<210> 738

<400> 738
000


<210> 739

<400> 739
000


<210> 740

<400> 740
000


<210> 741

<400> 741
000


<210> 742

<400> 742
000


<210> 743

<400> 743
000


<210> 744

<400> 744
000


<210> 745

<400> 745
000


<210> 746

<400> 746
000


<210> 747

<400> 747
000


<210> 748

<400> 748
000


<210> 749

<400> 749
000


<210> 750

<400> 750
000


<210> 751

<400> 751
000


<210> 752

<400> 752
000


<210> 753

<400> 753
000


<210> 754

<400> 754
000


<210> 755

<400> 755
000


<210> 756

<400> 756
000


<210> 757

<400> 757
000


<210> 758

<400> 758
000


<210> 759

<400> 759
000


<210> 760

<400> 760
000


<210> 761

<400> 761
000


<210> 762

<400> 762
000


<210> 763

<400> 763
000


<210> 764

<400> 764
000


<210> 765

<400> 765
000


<210> 766

<400> 766
000


<210> 767

<400> 767
000


<210> 768
<211> 1849
<212> PRT
<213> Homo sapiens

<400> 768
Met Pro Arg Ser Pro Thr Ser Ser Glu Asp Glu Met Ala Gln Ser Phe 
1               5                   10                  15      


Ser Asp Tyr Ser Val Gly Ser Glu Ser Asp Ser Ser Lys Glu Glu Thr 
            20                  25                  30          


Ile Tyr Asp Thr Ile Arg Ala Thr Ala Glu Lys Pro Gly Gly Ala Arg 
        35                  40                  45              


Thr Glu Glu Ser Gln Gly Asn Thr Leu Val Ile Arg Val Val Ile His 
    50                  55                  60                  


Asp Leu Gln Gln Thr Lys Cys Ile Arg Phe Asn Pro Asp Ala Thr Val 
65                  70                  75                  80  


Trp Val Ala Lys Gln Arg Ile Leu Cys Thr Leu Thr Gln Ser Leu Lys 
                85                  90                  95      


Asp Val Leu Asn Tyr Gly Leu Phe Gln Pro Ala Ser Asn Gly Arg Asp 
            100                 105                 110         


Gly Lys Phe Leu Asp Glu Glu Arg Leu Leu Arg Glu Tyr Pro Gln Pro 
        115                 120                 125             


Val Gly Glu Gly Val Pro Ser Leu Glu Phe Arg Tyr Lys Lys Arg Val 
    130                 135                 140                 


Tyr Lys Gln Ala Ser Leu Asp Glu Lys Gln Leu Ala Lys Leu His Thr 
145                 150                 155                 160 


Lys Thr Asn Leu Lys Lys Cys Met Asp His Ile Gln His Arg Leu Val 
                165                 170                 175     


Glu Lys Ile Thr Lys Met Leu Asp Arg Gly Leu Asp Pro Asn Phe His 
            180                 185                 190         


Asp Pro Glu Thr Gly Glu Thr Pro Leu Thr Leu Ala Ala Gln Leu Asp 
        195                 200                 205             


Asp Ser Val Glu Val Ile Lys Ala Leu Lys Asn Gly Gly Ala His Leu 
    210                 215                 220                 


Asp Phe Arg Ala Lys Asp Gly Met Thr Ala Leu His Lys Ala Ala Arg 
225                 230                 235                 240 


Ala Arg Asn Gln Val Ala Leu Lys Thr Leu Leu Glu Leu Gly Ala Ser 
                245                 250                 255     


Pro Asp Tyr Lys Asp Ser Tyr Gly Leu Thr Pro Leu Tyr His Thr Ala 
            260                 265                 270         


Ile Val Gly Gly Asp Pro Tyr Cys Cys Glu Leu Leu Leu His Glu His 
        275                 280                 285             


Ala Thr Val Cys Cys Lys Asp Glu Asn Gly Trp His Glu Ile His Gln 
    290                 295                 300                 


Ala Cys Arg Tyr Gly His Val Gln His Leu Glu His Leu Leu Phe Tyr 
305                 310                 315                 320 


Gly Ala Asp Met Ser Ala Gln Asn Ala Ser Gly Asn Thr Ala Leu His 
                325                 330                 335     


Ile Cys Ala Leu Tyr Asn Gln Asp Ser Cys Ala Arg Val Leu Leu Phe 
            340                 345                 350         


Arg Gly Gly Asn Lys Glu Leu Lys Asn Tyr Asn Ser Gln Thr Pro Phe 
        355                 360                 365             


Gln Val Ala Ile Ile Ala Gly Asn Phe Glu Leu Ala Glu Tyr Ile Lys 
    370                 375                 380                 


Asn His Lys Glu Thr Asp Ile Val Pro Phe Arg Glu Ala Pro Ala Tyr 
385                 390                 395                 400 


Ser Asn Arg Arg Arg Arg Pro Pro Asn Thr Leu Ala Ala Pro Arg Val 
                405                 410                 415     


Leu Leu Arg Ser Asn Ser Asp Asn Asn Leu Asn Ala Ser Ala Pro Asp 
            420                 425                 430         


Trp Ala Val Cys Ser Thr Ala Thr Ser His Arg Ser Leu Ser Pro Gln 
        435                 440                 445             


Leu Leu Gln Gln Met Pro Ser Lys Pro Glu Gly Ala Ala Lys Thr Ile 
    450                 455                 460                 


Gly Ser Tyr Val Pro Gly Pro Arg Ser Arg Ser Pro Ser Leu Asn Arg 
465                 470                 475                 480 


Leu Gly Gly Ala Gly Glu Asp Gly Lys Arg Pro Gln Pro Leu Trp His 
                485                 490                 495     


Val Gly Ser Pro Phe Ala Leu Gly Ala Asn Lys Asp Ser Leu Ser Ala 
            500                 505                 510         


Phe Glu Tyr Pro Gly Pro Lys Arg Lys Leu Tyr Ser Ala Val Pro Gly 
        515                 520                 525             


Arg Leu Phe Val Ala Val Lys Pro Tyr Gln Pro Gln Val Asp Gly Glu 
    530                 535                 540                 


Ile Pro Leu His Arg Gly Asp Arg Val Lys Val Leu Ser Ile Gly Glu 
545                 550                 555                 560 


Gly Gly Phe Trp Glu Gly Ser Ala Arg Gly His Ile Gly Trp Phe Pro 
                565                 570                 575     


Ala Glu Cys Val Glu Glu Val Gln Cys Lys Pro Arg Asp Ser Gln Ala 
            580                 585                 590         


Glu Thr Arg Ala Asp Arg Ser Lys Lys Leu Phe Arg His Tyr Thr Val 
        595                 600                 605             


Gly Ser Tyr Asp Ser Phe Asp Thr Ser Ser Asp Cys Ile Ile Glu Glu 
    610                 615                 620                 


Lys Thr Val Val Leu Gln Lys Lys Asp Asn Glu Gly Phe Gly Phe Val 
625                 630                 635                 640 


Leu Arg Gly Ala Lys Ala Asp Thr Pro Ile Glu Glu Phe Thr Pro Thr 
                645                 650                 655     


Pro Ala Phe Pro Ala Leu Gln Tyr Leu Glu Ser Val Asp Glu Gly Gly 
            660                 665                 670         


Val Ala Trp Gln Ala Gly Leu Arg Thr Gly Asp Phe Leu Ile Glu Val 
        675                 680                 685             


Asn Asn Glu Asn Val Val Lys Val Gly His Arg Gln Val Val Asn Met 
    690                 695                 700                 


Ile Arg Gln Gly Gly Asn His Leu Val Leu Lys Val Val Thr Val Thr 
705                 710                 715                 720 


Arg Asn Leu Asp Pro Asp Asp Thr Ala Arg Lys Lys Ala Pro Pro Pro 
                725                 730                 735     


Pro Lys Arg Ala Pro Thr Thr Ala Leu Thr Leu Arg Ser Lys Ser Met 
            740                 745                 750         


Thr Ser Glu Leu Glu Glu Leu Val Asp Lys Ala Ser Val Arg Lys Lys 
        755                 760                 765             


Lys Asp Lys Pro Glu Glu Ile Val Pro Ala Ser Lys Pro Ser Arg Ala 
    770                 775                 780                 


Ala Glu Asn Met Ala Val Glu Pro Arg Val Ala Thr Ile Lys Gln Arg 
785                 790                 795                 800 


Pro Ser Ser Arg Cys Phe Pro Ala Gly Ser Asp Met Asn Ser Val Tyr 
                805                 810                 815     


Glu Arg Gln Gly Ile Ala Val Met Thr Pro Thr Val Pro Gly Ser Pro 
            820                 825                 830         


Lys Ala Pro Phe Leu Gly Ile Pro Arg Gly Thr Met Arg Arg Gln Lys 
        835                 840                 845             


Ser Ile Asp Ser Arg Ile Phe Leu Ser Gly Ile Thr Glu Glu Glu Arg 
    850                 855                 860                 


Gln Phe Leu Ala Pro Pro Met Leu Lys Phe Thr Arg Ser Leu Ser Met 
865                 870                 875                 880 


Pro Asp Thr Ser Glu Asp Ile Pro Pro Pro Pro Gln Ser Val Pro Pro 
                885                 890                 895     


Ser Pro Pro Pro Pro Ser Pro Thr Thr Tyr Asn Cys Pro Lys Ser Pro 
            900                 905                 910         


Thr Pro Arg Val Tyr Gly Thr Ile Lys Pro Ala Phe Asn Gln Asn Ser 
        915                 920                 925             


Ala Ala Lys Val Ser Pro Ala Thr Arg Ser Asp Thr Val Ala Thr Met 
    930                 935                 940                 


Met Arg Glu Lys Gly Met Tyr Phe Arg Arg Glu Leu Asp Arg Tyr Ser 
945                 950                 955                 960 


Leu Asp Ser Glu Asp Leu Tyr Ser Arg Asn Ala Gly Pro Gln Ala Asn 
                965                 970                 975     


Phe Arg Asn Lys Arg Gly Gln Met Pro Glu Asn Pro Tyr Ser Glu Val 
            980                 985                 990         


Gly Lys Ile Ala Ser Lys Ala Val  Tyr Val Pro Ala Lys  Pro Ala Arg 
        995                 1000                 1005             


Arg Lys  Gly Met Leu Val Lys  Gln Ser Asn Val Glu  Asp Ser Pro 
    1010                 1015                 1020             


Glu Lys  Thr Cys Ser Ile Pro  Ile Pro Thr Ile Ile  Val Lys Glu 
    1025                 1030                 1035             


Pro Ser  Thr Ser Ser Ser Gly  Lys Ser Ser Gln Gly  Ser Ser Met 
    1040                 1045                 1050             


Glu Ile  Asp Pro Gln Ala Pro  Glu Pro Pro Ser Gln  Leu Arg Pro 
    1055                 1060                 1065             


Asp Glu  Ser Leu Thr Val Ser  Ser Pro Phe Ala Ala  Ala Ile Ala 
    1070                 1075                 1080             


Gly Ala  Val Arg Asp Arg Glu  Lys Arg Leu Glu Ala  Arg Arg Asn 
    1085                 1090                 1095             


Ser Pro  Ala Phe Leu Ser Thr  Asp Leu Gly Asp Glu  Asp Val Gly 
    1100                 1105                 1110             


Leu Gly  Pro Pro Ala Pro Arg  Thr Arg Pro Ser Met  Phe Pro Glu 
    1115                 1120                 1125             


Glu Gly  Asp Phe Ala Asp Glu  Asp Ser Ala Glu Gln  Leu Ser Ser 
    1130                 1135                 1140             


Pro Met  Pro Ser Ala Thr Pro  Arg Glu Pro Glu Asn  His Phe Val 
    1145                 1150                 1155             


Gly Gly  Ala Glu Ala Ser Ala  Pro Gly Glu Ala Gly  Arg Pro Leu 
    1160                 1165                 1170             


Asn Ser  Thr Ser Lys Ala Gln  Gly Pro Glu Ser Ser  Pro Ala Val 
    1175                 1180                 1185             


Pro Ser  Ala Ser Ser Gly Thr  Ala Gly Pro Gly Asn  Tyr Val His 
    1190                 1195                 1200             


Pro Leu  Thr Gly Arg Leu Leu  Asp Pro Ser Ser Pro  Leu Ala Leu 
    1205                 1210                 1215             


Ala Leu  Ser Ala Arg Asp Arg  Ala Met Lys Glu Ser  Gln Gln Gly 
    1220                 1225                 1230             


Pro Lys  Gly Glu Ala Pro Lys  Ala Asp Leu Asn Lys  Pro Leu Tyr 
    1235                 1240                 1245             


Ile Asp  Thr Lys Met Arg Pro  Ser Leu Asp Ala Gly  Phe Pro Thr 
    1250                 1255                 1260             


Val Thr  Arg Gln Asn Thr Arg  Gly Pro Leu Arg Arg  Gln Glu Thr 
    1265                 1270                 1275             


Glu Asn  Lys Tyr Glu Thr Asp  Leu Gly Arg Asp Arg  Lys Gly Asp 
    1280                 1285                 1290             


Asp Lys  Lys Asn Met Leu Ile  Asp Ile Met Asp Thr  Ser Gln Gln 
    1295                 1300                 1305             


Lys Ser  Ala Gly Leu Leu Met  Val His Thr Val Asp  Ala Thr Lys 
    1310                 1315                 1320             


Leu Asp  Asn Ala Leu Gln Glu  Glu Asp Glu Lys Ala  Glu Val Glu 
    1325                 1330                 1335             


Met Lys  Pro Asp Ser Ser Pro  Ser Glu Val Pro Glu  Gly Val Ser 
    1340                 1345                 1350             


Glu Thr  Glu Gly Ala Leu Gln  Ile Ser Ala Ala Pro  Glu Pro Thr 
    1355                 1360                 1365             


Thr Val  Pro Gly Arg Thr Ile  Val Ala Val Gly Ser  Met Glu Glu 
    1370                 1375                 1380             


Ala Val  Ile Leu Pro Phe Arg  Ile Pro Pro Pro Pro  Leu Ala Ser 
    1385                 1390                 1395             


Val Asp  Leu Asp Glu Asp Phe  Ile Phe Thr Glu Pro  Leu Pro Pro 
    1400                 1405                 1410             


Pro Leu  Glu Phe Ala Asn Ser  Phe Asp Ile Pro Asp  Asp Arg Ala 
    1415                 1420                 1425             


Ala Ser  Val Pro Ala Leu Ser  Asp Leu Val Lys Gln  Lys Lys Ser 
    1430                 1435                 1440             


Asp Thr  Pro Gln Ser Pro Ser  Leu Asn Ser Ser Gln  Pro Thr Asn 
    1445                 1450                 1455             


Ser Ala  Asp Ser Lys Lys Pro  Ala Ser Leu Ser Asn  Cys Leu Pro 
    1460                 1465                 1470             


Ala Ser  Phe Leu Pro Pro Pro  Glu Ser Phe Asp Ala  Val Ala Asp 
    1475                 1480                 1485             


Ser Gly  Ile Glu Glu Val Asp  Ser Arg Ser Ser Ser  Asp His His 
    1490                 1495                 1500             


Leu Glu  Thr Thr Ser Thr Ile  Ser Thr Val Ser Ser  Ile Ser Thr 
    1505                 1510                 1515             


Leu Ser  Ser Glu Gly Gly Glu  Asn Val Asp Thr Cys  Thr Val Tyr 
    1520                 1525                 1530             


Ala Asp  Gly Gln Ala Phe Met  Val Asp Lys Pro Pro  Val Pro Pro 
    1535                 1540                 1545             


Lys Pro  Lys Met Lys Pro Ile  Ile His Lys Ser Asn  Ala Leu Tyr 
    1550                 1555                 1560             


Gln Asp  Ala Leu Val Glu Glu  Asp Val Asp Ser Phe  Val Ile Pro 
    1565                 1570                 1575             


Pro Pro  Ala Pro Pro Pro Pro  Pro Gly Ser Ala Gln  Pro Gly Met 
    1580                 1585                 1590             


Ala Lys  Val Leu Gln Pro Arg  Thr Ser Lys Leu Trp  Gly Asp Val 
    1595                 1600                 1605             


Thr Glu  Ile Lys Ser Pro Ile  Leu Ser Gly Pro Lys  Ala Asn Val 
    1610                 1615                 1620             


Ile Ser  Glu Leu Asn Ser Ile  Leu Gln Gln Met Asn  Arg Glu Lys 
    1625                 1630                 1635             


Leu Ala  Lys Pro Gly Glu Gly  Leu Asp Ser Pro Met  Gly Ala Lys 
    1640                 1645                 1650             


Ser Ala  Ser Leu Ala Pro Arg  Ser Pro Glu Ile Met  Ser Thr Ile 
    1655                 1660                 1665             


Ser Gly  Thr Arg Ser Thr Thr  Val Thr Phe Thr Val  Arg Pro Gly 
    1670                 1675                 1680             


Thr Ser  Gln Pro Ile Thr Leu  Gln Ser Arg Pro Pro  Asp Tyr Glu 
    1685                 1690                 1695             


Ser Arg  Thr Ser Gly Thr Arg  Arg Ala Pro Ser Pro  Val Val Ser 
    1700                 1705                 1710             


Pro Thr  Glu Met Asn Lys Glu  Thr Leu Pro Ala Pro  Leu Ser Ala 
    1715                 1720                 1725             


Ala Thr  Ala Ser Pro Ser Pro  Ala Leu Ser Asp Val  Phe Ser Leu 
    1730                 1735                 1740             


Pro Ser  Gln Pro Pro Ser Gly  Asp Leu Phe Gly Leu  Asn Pro Ala 
    1745                 1750                 1755             


Gly Arg  Ser Arg Ser Pro Ser  Pro Ser Ile Leu Gln  Gln Pro Ile 
    1760                 1765                 1770             


Ser Asn  Lys Pro Phe Thr Thr  Lys Pro Val His Leu  Trp Thr Lys 
    1775                 1780                 1785             


Pro Asp  Val Ala Asp Trp Leu  Glu Ser Leu Asn Leu  Gly Glu His 
    1790                 1795                 1800             


Lys Glu  Ala Phe Met Asp Asn  Glu Ile Asp Gly Ser  His Leu Pro 
    1805                 1810                 1815             


Asn Leu  Gln Lys Glu Asp Leu  Ile Asp Leu Gly Val  Thr Arg Val 
    1820                 1825                 1830             


Gly His  Arg Met Asn Ile Glu  Arg Ala Leu Lys Gln  Leu Leu Asp 
    1835                 1840                 1845             


Arg 
    


<210> 769
<211> 1731
<212> PRT
<213> Homo sapiens

<400> 769
Met Asp Gly Pro Gly Ala Ser Ala Val Val Val Arg Val Gly Ile Pro 
1               5                   10                  15      


Asp Leu Gln Gln Thr Lys Cys Leu Arg Leu Asp Pro Ala Ala Pro Val 
            20                  25                  30          


Trp Ala Ala Lys Gln Arg Val Leu Cys Ala Leu Asn His Ser Leu Gln 
        35                  40                  45              


Asp Ala Leu Asn Tyr Gly Leu Phe Gln Pro Pro Ser Arg Gly Arg Ala 
    50                  55                  60                  


Gly Lys Phe Leu Asp Glu Glu Arg Leu Leu Gln Glu Tyr Pro Pro Asn 
65                  70                  75                  80  


Leu Asp Thr Pro Leu Pro Tyr Leu Glu Phe Arg Tyr Lys Arg Arg Val 
                85                  90                  95      


Tyr Ala Gln Asn Leu Ile Asp Asp Lys Gln Phe Ala Lys Leu His Thr 
            100                 105                 110         


Lys Ala Asn Leu Lys Lys Phe Met Asp Tyr Val Gln Leu His Ser Thr 
        115                 120                 125             


Asp Lys Val Ala Arg Leu Leu Asp Lys Gly Leu Asp Pro Asn Phe His 
    130                 135                 140                 


Asp Pro Asp Ser Gly Glu Cys Pro Leu Ser Leu Ala Ala Gln Leu Asp 
145                 150                 155                 160 


Asn Ala Thr Asp Leu Leu Lys Val Leu Lys Asn Gly Gly Ala His Leu 
                165                 170                 175     


Asp Phe Arg Thr Arg Asp Gly Leu Thr Ala Val His Cys Ala Thr Arg 
            180                 185                 190         


Gln Arg Asn Ala Ala Ala Leu Thr Thr Leu Leu Asp Leu Gly Ala Ser 
        195                 200                 205             


Pro Asp Tyr Lys Asp Ser Arg Gly Leu Thr Pro Leu Tyr His Ser Ala 
    210                 215                 220                 


Leu Gly Gly Gly Asp Ala Leu Cys Cys Glu Leu Leu Leu His Asp His 
225                 230                 235                 240 


Ala Gln Leu Gly Ile Thr Asp Glu Asn Gly Trp Gln Glu Ile His Gln 
                245                 250                 255     


Ala Cys Arg Phe Gly His Val Gln His Leu Glu His Leu Leu Phe Tyr 
            260                 265                 270         


Gly Ala Asp Met Gly Ala Gln Asn Ala Ser Gly Asn Thr Ala Leu His 
        275                 280                 285             


Ile Cys Ala Leu Tyr Asn Gln Glu Ser Cys Ala Arg Val Leu Leu Phe 
    290                 295                 300                 


Arg Gly Ala Asn Arg Asp Val Arg Asn Tyr Asn Ser Gln Thr Ala Phe 
305                 310                 315                 320 


Gln Val Ala Ile Ile Ala Gly Asn Phe Glu Leu Ala Glu Val Ile Lys 
                325                 330                 335     


Thr His Lys Asp Ser Asp Val Val Pro Phe Arg Glu Thr Pro Ser Tyr 
            340                 345                 350         


Ala Lys Arg Arg Arg Leu Ala Gly Pro Ser Gly Leu Ala Ser Pro Arg 
        355                 360                 365             


Pro Leu Gln Arg Ser Ala Ser Asp Ile Asn Leu Lys Gly Glu Ala Gln 
    370                 375                 380                 


Pro Ala Ala Ser Pro Gly Pro Ser Leu Arg Ser Leu Pro His Gln Leu 
385                 390                 395                 400 


Leu Leu Gln Arg Leu Gln Glu Glu Lys Asp Arg Asp Arg Asp Ala Asp 
                405                 410                 415     


Gln Glu Ser Asn Ile Ser Gly Pro Leu Ala Gly Arg Ala Gly Gln Ser 
            420                 425                 430         


Lys Ile Ser Pro Ser Gly Pro Gly Gly Pro Gly Pro Ala Pro Gly Pro 
        435                 440                 445             


Gly Pro Ala Pro Pro Ala Pro Pro Ala Pro Pro Pro Arg Gly Pro Lys 
    450                 455                 460                 


Arg Lys Leu Tyr Ser Ala Val Pro Gly Arg Lys Phe Ile Ala Val Lys 
465                 470                 475                 480 


Ala His Ser Pro Gln Gly Glu Gly Glu Ile Pro Leu His Arg Gly Glu 
                485                 490                 495     


Ala Val Lys Val Leu Ser Ile Gly Glu Gly Gly Phe Trp Glu Gly Thr 
            500                 505                 510         


Val Lys Gly Arg Thr Gly Trp Phe Pro Ala Asp Cys Val Glu Glu Val 
        515                 520                 525             


Gln Met Arg Gln His Asp Thr Arg Pro Glu Thr Arg Glu Asp Arg Thr 
    530                 535                 540                 


Lys Arg Leu Phe Arg His Tyr Thr Val Gly Ser Tyr Asp Ser Leu Thr 
545                 550                 555                 560 


Ser His Ser Asp Tyr Val Ile Asp Asp Lys Val Ala Val Leu Gln Lys 
                565                 570                 575     


Arg Asp His Glu Gly Phe Gly Phe Val Leu Arg Gly Ala Lys Ala Glu 
            580                 585                 590         


Thr Pro Ile Glu Glu Phe Thr Pro Thr Pro Ala Phe Pro Ala Leu Gln 
        595                 600                 605             


Tyr Leu Glu Ser Val Asp Val Glu Gly Val Ala Trp Arg Ala Gly Leu 
    610                 615                 620                 


Arg Thr Gly Asp Phe Leu Ile Glu Val Asn Gly Val Asn Val Val Lys 
625                 630                 635                 640 


Val Gly His Lys Gln Val Val Ala Leu Ile Arg Gln Gly Gly Asn Arg 
                645                 650                 655     


Leu Val Met Lys Val Val Ser Val Thr Arg Lys Pro Glu Glu Asp Gly 
            660                 665                 670         


Ala Arg Arg Arg Ala Pro Pro Pro Pro Lys Arg Ala Pro Ser Thr Thr 
        675                 680                 685             


Leu Thr Leu Arg Ser Lys Ser Met Thr Ala Glu Leu Glu Glu Leu Ala 
    690                 695                 700                 


Ser Ile Arg Arg Arg Lys Gly Glu Lys Leu Asp Glu Met Leu Ala Ala 
705                 710                 715                 720 


Ala Ala Glu Pro Thr Leu Arg Pro Asp Ile Ala Asp Ala Asp Ser Arg 
                725                 730                 735     


Ala Ala Thr Val Lys Gln Arg Pro Thr Ser Arg Arg Ile Thr Pro Ala 
            740                 745                 750         


Glu Ile Ser Ser Leu Phe Glu Arg Gln Gly Leu Pro Gly Pro Glu Lys 
        755                 760                 765             


Leu Pro Gly Ser Leu Arg Lys Gly Ile Pro Arg Thr Lys Ser Val Gly 
    770                 775                 780                 


Glu Asp Glu Lys Leu Ala Ser Leu Leu Glu Gly Arg Phe Pro Arg Ser 
785                 790                 795                 800 


Thr Ser Met Gln Asp Pro Val Arg Glu Gly Arg Gly Ile Pro Pro Pro 
                805                 810                 815     


Pro Gln Thr Ala Pro Pro Pro Pro Pro Ala Pro Tyr Tyr Phe Asp Ser 
            820                 825                 830         


Gly Pro Pro Pro Ala Phe Ser Pro Pro Pro Pro Pro Gly Arg Ala Tyr 
        835                 840                 845             


Asp Thr Val Arg Ser Ser Phe Lys Pro Gly Leu Glu Ala Arg Leu Gly 
    850                 855                 860                 


Ala Gly Ala Ala Gly Leu Tyr Glu Pro Gly Ala Ala Leu Gly Pro Leu 
865                 870                 875                 880 


Pro Tyr Pro Glu Arg Gln Lys Arg Ala Arg Ser Met Ile Ile Leu Gln 
                885                 890                 895     


Asp Ser Ala Pro Glu Ser Gly Asp Ala Pro Arg Pro Pro Pro Ala Ala 
            900                 905                 910         


Thr Pro Pro Glu Arg Pro Lys Arg Arg Pro Arg Pro Pro Gly Pro Asp 
        915                 920                 925             


Ser Pro Tyr Ala Asn Leu Gly Ala Phe Ser Ala Ser Leu Phe Ala Pro 
    930                 935                 940                 


Ser Lys Pro Gln Arg Arg Lys Ser Pro Leu Val Lys Gln Leu Gln Val 
945                 950                 955                 960 


Glu Asp Ala Gln Glu Arg Ala Ala Leu Ala Val Gly Ser Pro Gly Pro 
                965                 970                 975     


Gly Gly Gly Ser Phe Ala Arg Glu Pro Ser Pro Thr His Arg Gly Pro 
            980                 985                 990         


Arg Pro Gly Gly Leu Asp Tyr Gly  Ala Gly Asp Gly Pro  Gly Leu Ala 
        995                 1000                 1005             


Phe Gly  Gly Pro Gly Pro Ala  Lys Asp Arg Arg Leu  Glu Glu Arg 
    1010                 1015                 1020             


Arg Arg  Ser Thr Val Phe Leu  Ser Val Gly Ala Ile  Glu Gly Ser 
    1025                 1030                 1035             


Ala Pro  Gly Ala Asp Leu Pro  Ser Leu Gln Pro Ser  Arg Ser Ile 
    1040                 1045                 1050             


Asp Glu  Arg Leu Leu Gly Thr  Gly Pro Thr Ala Gly  Arg Asp Leu 
    1055                 1060                 1065             


Leu Leu  Pro Ser Pro Val Ser  Ala Leu Lys Pro Leu  Val Ser Gly 
    1070                 1075                 1080             


Pro Ser  Leu Gly Pro Ser Gly  Ser Thr Phe Ile His  Pro Leu Thr 
    1085                 1090                 1095             


Gly Lys  Pro Leu Asp Pro Ser  Ser Pro Leu Ala Leu  Ala Leu Ala 
    1100                 1105                 1110             


Ala Arg  Glu Arg Ala Leu Ala  Ser Gln Ala Pro Ser  Arg Ser Pro 
    1115                 1120                 1125             


Thr Pro  Val His Ser Pro Asp  Ala Asp Arg Pro Gly  Pro Leu Phe 
    1130                 1135                 1140             


Val Asp  Val Gln Ala Arg Asp  Pro Glu Arg Gly Ser  Leu Ala Ser 
    1145                 1150                 1155             


Pro Ala  Phe Ser Pro Arg Ser  Pro Ala Trp Ile Pro  Val Pro Ala 
    1160                 1165                 1170             


Arg Arg  Glu Ala Glu Lys Val  Pro Arg Glu Glu Arg  Lys Ser Pro 
    1175                 1180                 1185             


Glu Asp  Lys Lys Ser Met Ile  Leu Ser Val Leu Asp  Thr Ser Leu 
    1190                 1195                 1200             


Gln Arg  Pro Ala Gly Leu Ile  Val Val His Ala Thr  Ser Asn Gly 
    1205                 1210                 1215             


Gln Glu  Pro Ser Arg Leu Gly  Gly Ala Glu Glu Glu  Arg Pro Gly 
    1220                 1225                 1230             


Thr Pro  Glu Leu Ala Pro Ala  Pro Met Gln Ser Ala  Ala Val Ala 
    1235                 1240                 1245             


Glu Pro  Leu Pro Ser Pro Arg  Ala Gln Pro Pro Gly  Gly Thr Pro 
    1250                 1255                 1260             


Ala Asp  Ala Gly Pro Gly Gln  Gly Ser Ser Glu Glu  Glu Pro Glu 
    1265                 1270                 1275             


Leu Val  Phe Ala Val Asn Leu  Pro Pro Ala Gln Leu  Ser Ser Ser 
    1280                 1285                 1290             


Asp Glu  Glu Thr Arg Glu Glu  Leu Ala Arg Ile Gly  Leu Val Pro 
    1295                 1300                 1305             


Pro Pro  Glu Glu Phe Ala Asn  Gly Val Leu Leu Ala  Thr Pro Leu 
    1310                 1315                 1320             


Ala Gly  Pro Gly Pro Ser Pro  Thr Thr Val Pro Ser  Pro Ala Ser 
    1325                 1330                 1335             


Gly Lys  Pro Ser Ser Glu Pro  Pro Pro Ala Pro Glu  Ser Ala Ala 
    1340                 1345                 1350             


Asp Ser  Gly Val Glu Glu Ala  Asp Thr Arg Ser Ser  Ser Asp Pro 
    1355                 1360                 1365             


His Leu  Glu Thr Thr Ser Thr  Ile Ser Thr Val Ser  Ser Met Ser 
    1370                 1375                 1380             


Thr Leu  Ser Ser Glu Ser Gly  Glu Leu Thr Asp Thr  His Thr Ser 
    1385                 1390                 1395             


Phe Ala  Asp Gly His Thr Phe  Leu Leu Glu Lys Pro  Pro Val Pro 
    1400                 1405                 1410             


Pro Lys  Pro Lys Leu Lys Ser  Pro Leu Gly Lys Gly  Pro Val Thr 
    1415                 1420                 1425             


Phe Arg  Asp Pro Leu Leu Lys  Gln Ser Ser Asp Ser  Glu Leu Met 
    1430                 1435                 1440             


Ala Gln  Gln His His Ala Ala  Ser Ala Gly Leu Ala  Ser Ala Ala 
    1445                 1450                 1455             


Gly Pro  Ala Arg Pro Arg Tyr  Leu Phe Gln Arg Arg  Ser Lys Leu 
    1460                 1465                 1470             


Trp Gly  Asp Pro Val Glu Ser  Arg Gly Leu Pro Gly  Pro Glu Asp 
    1475                 1480                 1485             


Asp Lys  Pro Thr Val Ile Ser  Glu Leu Ser Ser Arg  Leu Gln Gln 
    1490                 1495                 1500             


Leu Asn  Lys Asp Thr Arg Ser  Leu Gly Glu Glu Pro  Val Gly Gly 
    1505                 1510                 1515             


Leu Gly  Ser Leu Leu Asp Pro  Ala Lys Lys Ser Pro  Ile Ala Ala 
    1520                 1525                 1530             


Ala Arg  Leu Phe Ser Ser Leu  Gly Glu Leu Ser Ser  Ile Ser Ala 
    1535                 1540                 1545             


Gln Arg  Ser Pro Gly Gly Pro  Gly Gly Gly Ala Ser  Tyr Ser Val 
    1550                 1555                 1560             


Arg Pro  Ser Gly Arg Tyr Pro  Val Ala Arg Arg Ala  Pro Ser Pro 
    1565                 1570                 1575             


Val Lys  Pro Ala Ser Leu Glu  Arg Val Glu Gly Leu  Gly Ala Gly 
    1580                 1585                 1590             


Ala Gly  Gly Ala Gly Arg Pro  Phe Gly Leu Thr Pro  Pro Thr Ile 
    1595                 1600                 1605             


Leu Lys  Ser Ser Ser Leu Ser  Ile Pro His Glu Pro  Lys Glu Val 
    1610                 1615                 1620             


Arg Phe  Val Val Arg Ser Val  Ser Ala Arg Ser Arg  Ser Pro Ser 
    1625                 1630                 1635             


Pro Ser  Pro Leu Pro Ser Pro  Ala Ser Gly Pro Gly  Pro Gly Ala 
    1640                 1645                 1650             


Pro Gly  Pro Arg Arg Pro Phe  Gln Gln Lys Pro Leu  Gln Leu Trp 
    1655                 1660                 1665             


Ser Lys  Phe Asp Val Gly Asp  Trp Leu Glu Ser Ile  His Leu Gly 
    1670                 1675                 1680             


Glu His  Arg Asp Arg Phe Glu  Asp His Glu Ile Glu  Gly Ala His 
    1685                 1690                 1695             


Leu Pro  Ala Leu Thr Lys Asp  Asp Phe Val Glu Leu  Gly Val Thr 
    1700                 1705                 1710             


Arg Val  Gly His Arg Met Asn  Ile Glu Arg Ala Leu  Arg Gln Leu 
    1715                 1720                 1725             


Asp Gly  Ser 
    1730     


<210> 770

<400> 770
000


<210> 771

<400> 771
000


<210> 772

<400> 772
000


<210> 773

<400> 773
000


<210> 774

<400> 774
000


<210> 775

<400> 775
000


<210> 776

<400> 776
000


<210> 777

<400> 777
000


<210> 778

<400> 778
000


<210> 779

<400> 779
000


<210> 780

<400> 780
000


<210> 781

<400> 781
000


<210> 782

<400> 782
000


<210> 783

<400> 783
000


<210> 784

<400> 784
000


<210> 785

<400> 785
000


<210> 786

<400> 786
000


<210> 787

<400> 787
000


<210> 788

<400> 788
000


<210> 789

<400> 789
000


<210> 790

<400> 790
000


<210> 791

<400> 791
000


<210> 792

<400> 792
000


<210> 793

<400> 793
000


<210> 794

<400> 794
000


<210> 795

<400> 795
000


<210> 796

<400> 796
000


<210> 797

<400> 797
000


<210> 798

<400> 798
000


<210> 799

<400> 799
000


<210> 800

<400> 800
000


<210> 801

<400> 801
000


<210> 802

<400> 802
000


<210> 803

<400> 803
000


<210> 804

<400> 804
000


<210> 805

<400> 805
000


<210> 806

<400> 806
000


<210> 807

<400> 807
000


<210> 808

<400> 808
000


<210> 809

<400> 809
000


<210> 810

<400> 810
000


<210> 811

<400> 811
000


<210> 812

<400> 812
000


<210> 813

<400> 813
000


<210> 814

<400> 814
000


<210> 815

<400> 815
000


<210> 816

<400> 816
000


<210> 817

<400> 817
000


<210> 818

<400> 818
000


<210> 819

<400> 819
000


<210> 820

<400> 820
000


<210> 821

<400> 821
000


<210> 822

<400> 822
000


<210> 823

<400> 823
000


<210> 824

<400> 824
000


<210> 825

<400> 825
000


<210> 826

<400> 826
000


<210> 827

<400> 827
000


<210> 828

<400> 828
000


<210> 829

<400> 829
000


<210> 830

<400> 830
000


<210> 831

<400> 831
000


<210> 832

<400> 832
000


<210> 833

<400> 833
000


<210> 834

<400> 834
000


<210> 835

<400> 835
000


<210> 836

<400> 836
000


<210> 837

<400> 837
000


<210> 838

<400> 838
000


<210> 839

<400> 839
000


<210> 840

<400> 840
000


<210> 841

<400> 841
000


<210> 842

<400> 842
000


<210> 843

<400> 843
000


<210> 844

<400> 844
000


<210> 845

<400> 845
000


<210> 846

<400> 846
000


<210> 847

<400> 847
000


<210> 848

<400> 848
000


<210> 849

<400> 849
000


<210> 850

<400> 850
000


<210> 851

<400> 851
000


<210> 852

<400> 852
000


<210> 853

<400> 853
000


<210> 854

<400> 854
000


<210> 855

<400> 855
000


<210> 856

<400> 856
000


<210> 857

<400> 857
000


<210> 858

<400> 858
000


<210> 859

<400> 859
000


<210> 860

<400> 860
000


<210> 861

<400> 861
000


<210> 862

<400> 862
000


<210> 863

<400> 863
000


<210> 864

<400> 864
000


<210> 865

<400> 865
000


<210> 866

<400> 866
000


<210> 867

<400> 867
000


<210> 868

<400> 868
000


<210> 869

<400> 869
000


<210> 870

<400> 870
000


<210> 871

<400> 871
000


<210> 872

<400> 872
000


<210> 873

<400> 873
000


<210> 874

<400> 874
000


<210> 875

<400> 875
000


<210> 876

<400> 876
000


<210> 877

<400> 877
000


<210> 878

<400> 878
000


<210> 879

<400> 879
000


<210> 880

<400> 880
000


<210> 881

<400> 881
000


<210> 882

<400> 882
000


<210> 883

<400> 883
000


<210> 884

<400> 884
000


<210> 885

<400> 885
000


<210> 886

<400> 886
000


<210> 887

<400> 887
000


<210> 888

<400> 888
000


<210> 889

<400> 889
000


<210> 890

<400> 890
000


<210> 891

<400> 891
000


<210> 892

<400> 892
000


<210> 893

<400> 893
000


<210> 894

<400> 894
000


<210> 895

<400> 895
000


<210> 896

<400> 896
000


<210> 897

<400> 897
000


<210> 898

<400> 898
000


<210> 899
<211> 1164
<212> PRT
<213> Homo sapiens

<400> 899
Met Ala Gln Gln Ala Asn Val Gly Glu Leu Leu Ala Met Leu Asp Ser 
1               5                   10                  15      


Pro Met Leu Gly Val Arg Asp Asp Val Thr Ala Val Phe Lys Glu Asn 
            20                  25                  30          


Leu Asn Ser Asp Arg Gly Pro Met Leu Val Asn Thr Leu Val Asp Tyr 
        35                  40                  45              


Tyr Leu Glu Thr Ser Ser Gln Pro Ala Leu His Ile Leu Thr Thr Leu 
    50                  55                  60                  


Gln Glu Pro His Asp Lys His Leu Leu Asp Arg Ile Asn Glu Tyr Val 
65                  70                  75                  80  


Gly Lys Ala Ala Thr Arg Leu Ser Ile Leu Ser Leu Leu Gly His Val 
                85                  90                  95      


Ile Arg Leu Gln Pro Ser Trp Lys His Lys Leu Ser Gln Ala Pro Leu 
            100                 105                 110         


Leu Pro Ser Leu Leu Lys Cys Leu Lys Met Asp Thr Asp Val Val Val 
        115                 120                 125             


Leu Thr Thr Gly Val Leu Val Leu Ile Thr Met Leu Pro Met Ile Pro 
    130                 135                 140                 


Gln Ser Gly Lys Gln His Leu Leu Asp Phe Phe Asp Ile Phe Gly Arg 
145                 150                 155                 160 


Leu Ser Ser Trp Cys Leu Lys Lys Pro Gly His Val Ala Glu Val Tyr 
                165                 170                 175     


Leu Val His Leu His Ala Ser Val Tyr Ala Leu Phe His Arg Leu Tyr 
            180                 185                 190         


Gly Met Tyr Pro Cys Asn Phe Val Ser Phe Leu Arg Ser His Tyr Ser 
        195                 200                 205             


Met Lys Glu Asn Leu Glu Thr Phe Glu Glu Val Val Lys Pro Met Met 
    210                 215                 220                 


Glu His Val Arg Ile His Pro Glu Leu Val Thr Gly Ser Lys Asp His 
225                 230                 235                 240 


Glu Leu Asp Pro Arg Arg Trp Lys Arg Leu Glu Thr His Asp Val Val 
                245                 250                 255     


Ile Glu Cys Ala Lys Ile Ser Leu Asp Pro Thr Glu Ala Ser Tyr Glu 
            260                 265                 270         


Asp Gly Tyr Ser Val Ser His Gln Ile Ser Ala Arg Phe Pro His Arg 
        275                 280                 285             


Ser Ala Asp Val Thr Thr Ser Pro Tyr Ala Asp Thr Gln Asn Ser Tyr 
    290                 295                 300                 


Gly Cys Ala Thr Ser Thr Pro Tyr Ser Thr Ser Arg Leu Met Leu Leu 
305                 310                 315                 320 


Asn Met Pro Gly Gln Leu Pro Gln Thr Leu Ser Ser Pro Ser Thr Arg 
                325                 330                 335     


Leu Ile Thr Glu Pro Pro Gln Ala Thr Leu Trp Ser Pro Ser Met Val 
            340                 345                 350         


Cys Gly Met Thr Thr Pro Pro Thr Ser Pro Gly Asn Val Pro Pro Asp 
        355                 360                 365             


Leu Ser His Pro Tyr Ser Lys Val Phe Gly Thr Thr Ala Gly Gly Lys 
    370                 375                 380                 


Gly Thr Pro Leu Gly Thr Pro Ala Thr Ser Pro Pro Pro Ala Pro Leu 
385                 390                 395                 400 


Cys His Ser Asp Asp Tyr Val His Ile Ser Leu Pro Gln Ala Thr Val 
                405                 410                 415     


Thr Pro Pro Arg Lys Glu Glu Arg Met Asp Ser Ala Arg Pro Cys Leu 
            420                 425                 430         


His Arg Gln His His Leu Leu Asn Asp Arg Gly Ser Glu Glu Pro Pro 
        435                 440                 445             


Gly Ser Lys Gly Ser Val Thr Leu Ser Asp Leu Pro Gly Phe Leu Gly 
    450                 455                 460                 


Asp Leu Ala Ser Glu Glu Asp Ser Ile Glu Lys Asp Lys Glu Glu Ala 
465                 470                 475                 480 


Ala Ile Ser Arg Glu Leu Ser Glu Ile Thr Thr Ala Glu Ala Glu Pro 
                485                 490                 495     


Val Val Pro Arg Gly Gly Phe Asp Ser Pro Phe Tyr Arg Asp Ser Leu 
            500                 505                 510         


Pro Gly Ser Gln Arg Lys Thr His Ser Ala Ala Ser Ser Ser Gln Gly 
        515                 520                 525             


Ala Ser Val Asn Pro Glu Pro Leu His Ser Ser Leu Asp Lys Leu Gly 
    530                 535                 540                 


Pro Asp Thr Pro Lys Gln Ala Phe Thr Pro Ile Asp Leu Pro Cys Gly 
545                 550                 555                 560 


Ser Ala Asp Glu Ser Pro Ala Gly Asp Arg Glu Cys Gln Thr Ser Leu 
                565                 570                 575     


Glu Thr Ser Ile Phe Thr Pro Ser Pro Cys Lys Ile Pro Pro Pro Thr 
            580                 585                 590         


Arg Val Gly Phe Gly Ser Gly Gln Pro Pro Pro Tyr Asp His Leu Phe 
        595                 600                 605             


Glu Val Ala Leu Pro Lys Thr Ala His His Phe Val Ile Arg Lys Thr 
    610                 615                 620                 


Glu Glu Leu Leu Lys Lys Ala Lys Gly Asn Thr Glu Glu Asp Gly Val 
625                 630                 635                 640 


Pro Ser Thr Ser Pro Met Glu Val Leu Asp Arg Leu Ile Gln Gln Gly 
                645                 650                 655     


Ala Asp Ala His Ser Lys Glu Leu Asn Lys Leu Pro Leu Pro Ser Lys 
            660                 665                 670         


Ser Val Asp Trp Thr His Phe Gly Gly Ser Pro Pro Ser Asp Glu Ile 
        675                 680                 685             


Arg Thr Leu Arg Asp Gln Leu Leu Leu Leu His Asn Gln Leu Leu Tyr 
    690                 695                 700                 


Glu Arg Phe Lys Arg Gln Gln His Ala Leu Arg Asn Arg Arg Leu Leu 
705                 710                 715                 720 


Arg Lys Val Ile Lys Ala Ala Ala Leu Glu Glu His Asn Ala Ala Met 
                725                 730                 735     


Lys Asp Gln Leu Lys Leu Gln Glu Lys Asp Ile Gln Met Trp Lys Val 
            740                 745                 750         


Ser Leu Gln Lys Glu Gln Ala Arg Tyr Asn Gln Leu Gln Glu Gln Arg 
        755                 760                 765             


Asp Thr Met Val Thr Lys Leu His Ser Gln Ile Arg Gln Leu Gln His 
    770                 775                 780                 


Asp Arg Glu Glu Phe Tyr Asn Gln Ser Gln Glu Leu Gln Thr Lys Leu 
785                 790                 795                 800 


Glu Asp Cys Arg Asn Met Ile Ala Glu Leu Arg Ile Glu Leu Lys Lys 
                805                 810                 815     


Ala Asn Asn Lys Val Cys His Thr Glu Leu Leu Leu Ser Gln Val Ser 
            820                 825                 830         


Gln Lys Leu Ser Asn Ser Glu Ser Val Gln Gln Gln Met Glu Phe Leu 
        835                 840                 845             


Asn Arg Gln Leu Leu Val Leu Gly Glu Val Asn Glu Leu Tyr Leu Glu 
    850                 855                 860                 


Gln Leu Gln Asn Lys His Ser Asp Thr Thr Lys Glu Val Glu Met Met 
865                 870                 875                 880 


Lys Ala Ala Tyr Arg Lys Glu Leu Glu Lys Asn Arg Ser His Val Leu 
                885                 890                 895     


Gln Gln Thr Gln Arg Leu Asp Thr Ser Gln Lys Arg Ile Leu Glu Leu 
            900                 905                 910         


Glu Ser His Leu Ala Lys Lys Asp His Leu Leu Leu Glu Gln Lys Lys 
        915                 920                 925             


Tyr Leu Glu Asp Val Lys Leu Gln Ala Arg Gly Gln Leu Gln Ala Ala 
    930                 935                 940                 


Glu Ser Arg Tyr Glu Ala Gln Lys Arg Ile Thr Gln Val Phe Glu Leu 
945                 950                 955                 960 


Glu Ile Leu Asp Leu Tyr Gly Arg Leu Glu Lys Asp Gly Leu Leu Lys 
                965                 970                 975     


Lys Leu Glu Glu Glu Lys Ala Glu Ala Ala Glu Ala Ala Glu Glu Arg 
            980                 985                 990         


Leu Asp Cys Cys Asn Asp Gly Cys  Ser Asp Ser Met Val  Gly His Asn 
        995                 1000                 1005             


Glu Glu  Ala Ser Gly His Asn  Gly Glu Thr Lys Thr  Pro Arg Pro 
    1010                 1015                 1020             


Ser Ser  Ala Arg Gly Ser Ser  Gly Ser Arg Gly Gly  Gly Gly Ser 
    1025                 1030                 1035             


Ser Ser  Ser Ser Ser Glu Leu  Ser Thr Pro Glu Lys  Pro Pro His 
    1040                 1045                 1050             


Gln Arg  Ala Gly Pro Phe Ser  Ser Arg Trp Glu Thr  Thr Met Gly 
    1055                 1060                 1065             


Glu Ala  Ser Ala Ser Ile Pro  Thr Thr Val Gly Ser  Leu Pro Ser 
    1070                 1075                 1080             


Ser Lys  Ser Phe Leu Gly Met  Lys Ala Arg Glu Leu  Phe Arg Asn 
    1085                 1090                 1095             


Lys Ser  Glu Ser Gln Cys Asp  Glu Asp Gly Met Thr  Ser Ser Leu 
    1100                 1105                 1110             


Ser Glu  Ser Leu Lys Thr Glu  Leu Gly Lys Asp Leu  Gly Val Glu 
    1115                 1120                 1125             


Ala Lys  Ile Pro Leu Asn Leu  Asp Gly Pro His Pro  Ser Pro Pro 
    1130                 1135                 1140             


Thr Pro  Asp Ser Val Gly Gln  Leu His Ile Met Asp  Tyr Asn Glu 
    1145                 1150                 1155             


Thr His  His Glu His Ser 
    1160                 


<210> 900
<211> 1807
<212> PRT
<213> Homo sapiens

<400> 900
Met Ala Lys Pro Thr Ser Lys Asp Ser Gly Leu Lys Glu Lys Phe Lys 
1               5                   10                  15      


Ile Leu Leu Gly Leu Gly Thr Pro Arg Pro Asn Pro Arg Ser Ala Glu 
            20                  25                  30          


Gly Lys Gln Thr Glu Phe Ile Ile Thr Ala Glu Ile Leu Arg Glu Leu 
        35                  40                  45              


Ser Met Glu Cys Gly Leu Asn Asn Arg Ile Arg Met Ile Gly Gln Ile 
    50                  55                  60                  


Cys Glu Val Ala Lys Thr Lys Lys Phe Glu Glu His Ala Val Glu Ala 
65                  70                  75                  80  


Leu Trp Lys Ala Val Ala Asp Leu Leu Gln Pro Glu Arg Pro Leu Glu 
                85                  90                  95      


Ala Arg His Ala Val Leu Ala Leu Leu Lys Ala Ile Val Gln Gly Gln 
            100                 105                 110         


Gly Glu Arg Leu Gly Val Leu Arg Ala Leu Phe Phe Lys Val Ile Lys 
        115                 120                 125             


Asp Tyr Pro Ser Asn Glu Asp Leu His Glu Arg Leu Glu Val Phe Lys 
    130                 135                 140                 


Ala Leu Thr Asp Asn Gly Arg His Ile Thr Tyr Leu Glu Glu Glu Leu 
145                 150                 155                 160 


Ala Asp Phe Val Leu Gln Trp Met Asp Val Gly Leu Ser Ser Glu Phe 
                165                 170                 175     


Leu Leu Val Leu Val Asn Leu Val Lys Phe Asn Ser Cys Tyr Leu Asp 
            180                 185                 190         


Glu Tyr Ile Ala Arg Met Val Gln Met Ile Cys Leu Leu Cys Val Arg 
        195                 200                 205             


Thr Ala Ser Ser Val Asp Ile Glu Val Ser Leu Gln Val Leu Asp Ala 
    210                 215                 220                 


Val Val Cys Tyr Asn Cys Leu Pro Ala Glu Ser Leu Pro Leu Phe Ile 
225                 230                 235                 240 


Val Thr Leu Cys Arg Thr Ile Asn Val Lys Glu Leu Cys Glu Pro Cys 
                245                 250                 255     


Trp Lys Leu Met Arg Asn Leu Leu Gly Thr His Leu Gly His Ser Ala 
            260                 265                 270         


Ile Tyr Asn Met Cys His Leu Met Glu Asp Arg Ala Tyr Met Glu Asp 
        275                 280                 285             


Ala Pro Leu Leu Arg Gly Ala Val Phe Phe Val Gly Met Ala Leu Trp 
    290                 295                 300                 


Gly Ala His Arg Leu Tyr Ser Leu Arg Asn Ser Pro Thr Ser Val Leu 
305                 310                 315                 320 


Pro Ser Phe Tyr Gln Ala Met Ala Cys Pro Asn Glu Val Val Ser Tyr 
                325                 330                 335     


Glu Ile Val Leu Ser Ile Thr Arg Leu Ile Lys Lys Tyr Arg Lys Glu 
            340                 345                 350         


Leu Gln Val Val Ala Trp Asp Ile Leu Leu Asn Ile Ile Glu Arg Leu 
        355                 360                 365             


Leu Gln Gln Leu Gln Thr Leu Asp Ser Pro Glu Leu Arg Thr Ile Val 
    370                 375                 380                 


His Asp Leu Leu Thr Thr Val Glu Glu Leu Cys Asp Gln Asn Glu Phe 
385                 390                 395                 400 


His Gly Ser Gln Glu Arg Tyr Phe Glu Leu Val Glu Arg Cys Ala Asp 
                405                 410                 415     


Gln Arg Pro Glu Ser Ser Leu Leu Asn Leu Ile Ser Tyr Arg Ala Gln 
            420                 425                 430         


Ser Ile His Pro Ala Lys Asp Gly Trp Ile Gln Asn Leu Gln Ala Leu 
        435                 440                 445             


Met Glu Arg Phe Phe Arg Ser Glu Ser Arg Gly Ala Val Arg Ile Lys 
    450                 455                 460                 


Val Leu Asp Val Leu Ser Phe Val Leu Leu Ile Asn Arg Gln Phe Tyr 
465                 470                 475                 480 


Glu Glu Glu Leu Ile Asn Ser Val Val Ile Ser Gln Leu Ser His Ile 
                485                 490                 495     


Pro Glu Asp Lys Asp His Gln Val Arg Lys Leu Ala Thr Gln Leu Leu 
            500                 505                 510         


Val Asp Leu Ala Glu Gly Cys His Thr His His Phe Asn Ser Leu Leu 
        515                 520                 525             


Asp Ile Ile Glu Lys Val Met Ala Arg Ser Leu Ser Pro Pro Pro Glu 
    530                 535                 540                 


Leu Glu Glu Arg Asp Val Ala Ala Tyr Ser Ala Ser Leu Glu Asp Val 
545                 550                 555                 560 


Lys Thr Ala Val Leu Gly Leu Leu Val Ile Leu Gln Thr Lys Leu Tyr 
                565                 570                 575     


Thr Leu Pro Ala Ser His Ala Thr Arg Val Tyr Glu Met Leu Val Ser 
            580                 585                 590         


His Ile Gln Leu His Tyr Lys His Ser Tyr Thr Leu Pro Ile Ala Ser 
        595                 600                 605             


Ser Ile Arg Leu Gln Ala Phe Asp Phe Leu Leu Leu Leu Arg Ala Asp 
    610                 615                 620                 


Ser Leu His Arg Leu Gly Leu Pro Asn Lys Asp Gly Val Val Arg Phe 
625                 630                 635                 640 


Ser Pro Tyr Cys Val Cys Asp Tyr Met Glu Pro Glu Arg Gly Ser Glu 
                645                 650                 655     


Lys Lys Thr Ser Gly Pro Leu Ser Pro Pro Thr Gly Pro Pro Gly Pro 
            660                 665                 670         


Ala Pro Ala Gly Pro Ala Val Arg Leu Gly Ser Val Pro Tyr Ser Leu 
        675                 680                 685             


Leu Phe Arg Val Leu Leu Gln Cys Leu Lys Gln Glu Ser Asp Trp Lys 
    690                 695                 700                 


Val Leu Lys Leu Val Leu Gly Arg Leu Pro Glu Ser Leu Arg Tyr Lys 
705                 710                 715                 720 


Val Leu Ile Phe Thr Ser Pro Cys Ser Val Asp Gln Leu Cys Ser Ala 
                725                 730                 735     


Leu Cys Ser Met Leu Ser Gly Pro Lys Thr Leu Glu Arg Leu Arg Gly 
            740                 745                 750         


Ala Pro Glu Gly Phe Ser Arg Thr Asp Leu His Leu Ala Val Val Pro 
        755                 760                 765             


Val Leu Thr Ala Leu Ile Ser Tyr His Asn Tyr Leu Asp Lys Thr Lys 
    770                 775                 780                 


Gln Arg Glu Met Val Tyr Cys Leu Glu Gln Gly Leu Ile His Arg Cys 
785                 790                 795                 800 


Ala Ser Gln Cys Val Val Ala Leu Ser Ile Cys Ser Val Glu Met Pro 
                805                 810                 815     


Asp Ile Ile Ile Lys Ala Leu Pro Val Leu Val Val Lys Leu Thr His 
            820                 825                 830         


Ile Ser Ala Thr Ala Ser Met Ala Val Pro Leu Leu Glu Phe Leu Ser 
        835                 840                 845             


Thr Leu Ala Arg Leu Pro His Leu Tyr Arg Asn Phe Ala Ala Glu Gln 
    850                 855                 860                 


Tyr Ala Ser Val Phe Ala Ile Ser Leu Pro Tyr Thr Asn Pro Ser Lys 
865                 870                 875                 880 


Phe Asn Gln Tyr Ile Val Cys Leu Ala His His Val Ile Ala Met Trp 
                885                 890                 895     


Phe Ile Arg Cys Arg Leu Pro Phe Arg Lys Asp Phe Val Pro Phe Ile 
            900                 905                 910         


Thr Lys Gly Leu Arg Ser Asn Val Leu Leu Ser Phe Asp Asp Thr Pro 
        915                 920                 925             


Glu Lys Asp Ser Phe Arg Ala Arg Ser Thr Ser Leu Asn Glu Arg Pro 
    930                 935                 940                 


Lys Ser Leu Arg Ile Ala Arg Pro Pro Lys Gln Gly Leu Asn Asn Ser 
945                 950                 955                 960 


Pro Pro Val Lys Glu Phe Lys Glu Ser Ser Ala Ala Glu Ala Phe Arg 
                965                 970                 975     


Cys Arg Ser Ile Ser Val Ser Glu His Val Val Arg Ser Arg Ile Gln 
            980                 985                 990         


Thr Ser Leu Thr Ser Ala Ser Leu  Gly Ser Ala Asp Glu  Asn Ser Val 
        995                 1000                 1005             


Ala Gln  Ala Asp Asp Ser Leu  Lys Asn Leu His Leu  Glu Leu Thr 
    1010                 1015                 1020             


Glu Thr  Cys Leu Asp Met Met  Ala Arg Tyr Val Phe  Ser Asn Phe 
    1025                 1030                 1035             


Thr Ala  Val Pro Lys Arg Ser  Pro Val Gly Glu Phe  Leu Leu Ala 
    1040                 1045                 1050             


Gly Gly  Arg Thr Lys Thr Trp  Leu Val Gly Asn Lys  Leu Val Thr 
    1055                 1060                 1065             


Val Thr  Thr Ser Val Gly Thr  Gly Thr Arg Ser Leu  Leu Gly Leu 
    1070                 1075                 1080             


Asp Ser  Gly Glu Leu Gln Ser  Gly Pro Glu Ser Ser  Ser Ser Pro 
    1085                 1090                 1095             


Gly Val  His Val Arg Gln Thr  Lys Glu Ala Pro Ala  Lys Leu Glu 
    1100                 1105                 1110             


Ser Gln  Ala Gly Gln Gln Val  Ser Arg Gly Ala Arg  Asp Arg Val 
    1115                 1120                 1125             


Arg Ser  Met Ser Gly Gly His  Gly Leu Arg Val Gly  Ala Leu Asp 
    1130                 1135                 1140             


Val Pro  Ala Ser Gln Phe Leu  Gly Ser Ala Thr Ser  Pro Gly Pro 
    1145                 1150                 1155             


Arg Thr  Ala Pro Ala Ala Lys  Pro Glu Lys Ala Ser  Ala Gly Thr 
    1160                 1165                 1170             


Arg Val  Pro Val Gln Glu Lys  Thr Asn Leu Ala Ala  Tyr Val Pro 
    1175                 1180                 1185             


Leu Leu  Thr Gln Gly Trp Ala  Glu Ile Leu Val Arg  Arg Pro Thr 
    1190                 1195                 1200             


Gly Asn  Thr Ser Trp Leu Met  Ser Leu Glu Asn Pro  Leu Ser Pro 
    1205                 1210                 1215             


Phe Ser  Ser Asp Ile Asn Asn  Met Pro Leu Gln Glu  Leu Ser Asn 
    1220                 1225                 1230             


Ala Leu  Met Ala Ala Glu Arg  Phe Lys Glu His Arg  Asp Thr Ala 
    1235                 1240                 1245             


Leu Tyr  Lys Ser Leu Ser Val  Pro Ala Ala Ser Thr  Ala Lys Pro 
    1250                 1255                 1260             


Pro Pro  Leu Pro Arg Ser Asn  Thr Val Ala Ser Phe  Ser Ser Leu 
    1265                 1270                 1275             


Tyr Gln  Ser Ser Cys Gln Gly  Gln Leu His Arg Ser  Val Ser Trp 
    1280                 1285                 1290             


Ala Asp  Ser Ala Val Val Met  Glu Glu Gly Ser Pro  Gly Glu Val 
    1295                 1300                 1305             


Pro Val  Leu Val Glu Pro Pro  Gly Leu Glu Asp Val  Glu Ala Ala 
    1310                 1315                 1320             


Leu Gly  Met Asp Arg Arg Thr  Asp Ala Tyr Ser Arg  Ser Ser Ser 
    1325                 1330                 1335             


Val Ser  Ser Gln Glu Glu Lys  Ser Leu His Ala Glu  Glu Leu Val 
    1340                 1345                 1350             


Gly Arg  Gly Ile Pro Ile Glu  Arg Val Val Ser Ser  Glu Gly Gly 
    1355                 1360                 1365             


Arg Pro  Ser Val Asp Leu Ser  Phe Gln Pro Ser Gln  Pro Leu Ser 
    1370                 1375                 1380             


Lys Ser  Ser Ser Ser Pro Glu  Leu Gln Thr Leu Gln  Asp Ile Leu 
    1385                 1390                 1395             


Gly Asp  Pro Gly Asp Lys Ala  Asp Val Gly Arg Leu  Ser Pro Glu 
    1400                 1405                 1410             


Val Lys  Ala Arg Ser Gln Ser  Gly Thr Leu Asp Gly  Glu Ser Ala 
    1415                 1420                 1425             


Ala Trp  Ser Ala Ser Gly Glu  Asp Ser Arg Gly Gln  Pro Glu Gly 
    1430                 1435                 1440             


Pro Leu  Pro Ser Ser Ser Pro  Arg Ser Pro Ser Gly  Leu Arg Pro 
    1445                 1450                 1455             


Arg Gly  Tyr Thr Ile Ser Asp  Ser Ala Pro Ser Arg  Arg Gly Lys 
    1460                 1465                 1470             


Arg Val  Glu Arg Asp Ala Leu  Lys Ser Arg Ala Thr  Ala Ser Asn 
    1475                 1480                 1485             


Ala Glu  Lys Val Pro Gly Ile  Asn Pro Ser Phe Val  Phe Leu Gln 
    1490                 1495                 1500             


Leu Tyr  His Ser Pro Phe Phe  Gly Asp Glu Ser Asn  Lys Pro Ile 
    1505                 1510                 1515             


Leu Leu  Pro Asn Glu Ser Gln  Ser Phe Glu Arg Ser  Val Gln Leu 
    1520                 1525                 1530             


Leu Asp  Gln Ile Pro Ser Tyr  Asp Thr His Lys Ile  Ala Val Leu 
    1535                 1540                 1545             


Tyr Val  Gly Glu Gly Gln Ser  Asn Ser Glu Leu Ala  Ile Leu Ser 
    1550                 1555                 1560             


Asn Glu  His Gly Ser Tyr Arg  Tyr Thr Glu Phe Leu  Thr Gly Leu 
    1565                 1570                 1575             


Gly Arg  Leu Ile Glu Leu Lys  Asp Cys Gln Pro Asp  Lys Val Tyr 
    1580                 1585                 1590             


Leu Gly  Gly Leu Asp Val Cys  Gly Glu Asp Gly Gln  Phe Thr Tyr 
    1595                 1600                 1605             


Cys Trp  His Asp Asp Ile Met  Gln Ala Val Phe His  Ile Ala Thr 
    1610                 1615                 1620             


Leu Met  Pro Thr Lys Asp Val  Asp Lys His Arg Cys  Asp Lys Lys 
    1625                 1630                 1635             


Arg His  Leu Gly Asn Asp Phe  Val Ser Ile Val Tyr  Asn Asp Ser 
    1640                 1645                 1650             


Gly Glu  Asp Phe Lys Leu Gly  Thr Ile Lys Gly Gln  Phe Asn Phe 
    1655                 1660                 1665             


Val His  Val Ile Val Thr Pro  Leu Asp Tyr Glu Cys  Asn Leu Val 
    1670                 1675                 1680             


Ser Leu  Gln Cys Arg Lys Asp  Met Glu Gly Leu Val  Asp Thr Ser 
    1685                 1690                 1695             


Val Ala  Lys Ile Val Ser Asp  Arg Asn Leu Pro Phe  Val Ala Arg 
    1700                 1705                 1710             


Gln Met  Ala Leu His Ala Asn  Met Ala Ser Gln Val  His His Ser 
    1715                 1720                 1725             


Arg Ser  Asn Pro Thr Asp Ile  Tyr Pro Ser Lys Trp  Ile Ala Arg 
    1730                 1735                 1740             


Leu Arg  His Ile Lys Arg Leu  Arg Gln Arg Ile Cys  Glu Glu Ala 
    1745                 1750                 1755             


Ala Tyr  Ser Asn Pro Ser Leu  Pro Leu Val His Pro  Pro Ser His 
    1760                 1765                 1770             


Ser Lys  Ala Pro Ala Gln Thr  Pro Ala Glu Pro Thr  Pro Gly Tyr 
    1775                 1780                 1785             


Glu Val  Gly Gln Arg Lys Arg  Leu Ile Ser Ser Val  Glu Asp Phe 
    1790                 1795                 1800             


Thr Glu  Phe Val 
    1805         


<210> 901

<400> 901
000


<210> 902

<400> 902
000


<210> 903

<400> 903
000


<210> 904

<400> 904
000


<210> 905

<400> 905
000


<210> 906

<400> 906
000


<210> 907

<400> 907
000


<210> 908

<400> 908
000


<210> 909

<400> 909
000


<210> 910

<400> 910
000


<210> 911

<400> 911
000


<210> 912

<400> 912
000


<210> 913

<400> 913
000


<210> 914

<400> 914
000


<210> 915

<400> 915
000


<210> 916

<400> 916
000


<210> 917

<400> 917
000


<210> 918

<400> 918
000


<210> 919

<400> 919
000


<210> 920

<400> 920
000


<210> 921

<400> 921
000


<210> 922

<400> 922
000


<210> 923

<400> 923
000


<210> 924

<400> 924
000


<210> 925

<400> 925
000


<210> 926

<400> 926
000


<210> 927

<400> 927
000


<210> 928

<400> 928
000


<210> 929

<400> 929
000


<210> 930

<400> 930
000


<210> 931

<400> 931
000


<210> 932

<400> 932
000


<210> 933

<400> 933
000


<210> 934

<400> 934
000


<210> 935

<400> 935
000


<210> 936

<400> 936
000


<210> 937

<400> 937
000


<210> 938

<400> 938
000


<210> 939

<400> 939
000


<210> 940

<400> 940
000


<210> 941

<400> 941
000


<210> 942

<400> 942
000


<210> 943

<400> 943
000


<210> 944

<400> 944
000


<210> 945

<400> 945
000


<210> 946

<400> 946
000


<210> 947

<400> 947
000


<210> 948

<400> 948
000


<210> 949

<400> 949
000


<210> 950

<400> 950
000


<210> 951

<400> 951
000


<210> 952

<400> 952
000


<210> 953

<400> 953
000


<210> 954

<400> 954
000


<210> 955

<400> 955
000


<210> 956

<400> 956
000


<210> 957

<400> 957
000


<210> 958

<400> 958
000


<210> 959

<400> 959
000


<210> 960

<400> 960
000


<210> 961

<400> 961
000


<210> 962

<400> 962
000


<210> 963

<400> 963
000


<210> 964

<400> 964
000


<210> 965

<400> 965
000


<210> 966

<400> 966
000


<210> 967

<400> 967
000


<210> 968
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 968
acacacac                                                                 8


<210> 969
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 969
acatacac                                                                 8


<210> 970
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 970
atacacac                                                                 8


<210> 971
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 971
atatacac                                                                 8


<210> 972
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 972
acgcacac                                                                 8


<210> 973
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 973
acgtacac                                                                 8


<210> 974
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 974
atgcacac                                                                 8


<210> 975
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 975
atgtacac                                                                 8


<210> 976
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 976
hyrydcay                                                                 8


<210> 977
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 977
ccaaacac                                                                 8


<210> 978
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 978
gattacag                                                                 8


