                         SEQUENCE LISTING

<110>  Aarhus Universitet
 
<120>  Single domain antibodies for complement regulation

<130>  P4890PC00

<160>  85    

<170>  PatentIn version 3.5

<210>  1
<211>  1641
<212>  PRT
<213>  Homo sapiens

<400>  1

Ser Pro Met Tyr Ser Ile Ile Thr Pro Asn Ile Leu Arg Leu Glu Ser 
1               5                   10                  15      


Glu Glu Thr Met Val Leu Glu Ala His Asp Ala Gln Gly Asp Val Pro 
            20                  25                  30          


Val Thr Val Thr Val His Asp Phe Pro Gly Lys Lys Leu Val Leu Ser 
        35                  40                  45              


Ser Glu Lys Thr Val Leu Thr Pro Ala Thr Asn His Met Gly Asn Val 
    50                  55                  60                  


Thr Phe Thr Ile Pro Ala Asn Arg Glu Phe Lys Ser Glu Lys Gly Arg 
65                  70                  75                  80  


Asn Lys Phe Val Thr Val Gln Ala Thr Phe Gly Thr Gln Val Val Glu 
                85                  90                  95      


Lys Val Val Leu Val Ser Leu Gln Ser Gly Tyr Leu Phe Ile Gln Thr 
            100                 105                 110         


Asp Lys Thr Ile Tyr Thr Pro Gly Ser Thr Val Leu Tyr Arg Ile Phe 
        115                 120                 125             


Thr Val Asn His Lys Leu Leu Pro Val Gly Arg Thr Val Met Val Asn 
    130                 135                 140                 


Ile Glu Asn Pro Glu Gly Ile Pro Val Lys Gln Asp Ser Leu Ser Ser 
145                 150                 155                 160 


Gln Asn Gln Leu Gly Val Leu Pro Leu Ser Trp Asp Ile Pro Glu Leu 
                165                 170                 175     


Val Asn Met Gly Gln Trp Lys Ile Arg Ala Tyr Tyr Glu Asn Ser Pro 
            180                 185                 190         


Gln Gln Val Phe Ser Thr Glu Phe Glu Val Lys Glu Tyr Val Leu Pro 
        195                 200                 205             


Ser Phe Glu Val Ile Val Glu Pro Thr Glu Lys Phe Tyr Tyr Ile Tyr 
    210                 215                 220                 


Asn Glu Lys Gly Leu Glu Val Thr Ile Thr Ala Arg Phe Leu Tyr Gly 
225                 230                 235                 240 


Lys Lys Val Glu Gly Thr Ala Phe Val Ile Phe Gly Ile Gln Asp Gly 
                245                 250                 255     


Glu Gln Arg Ile Ser Leu Pro Glu Ser Leu Lys Arg Ile Pro Ile Glu 
            260                 265                 270         


Asp Gly Ser Gly Glu Val Val Leu Ser Arg Lys Val Leu Leu Asp Gly 
        275                 280                 285             


Val Gln Asn Pro Arg Ala Glu Asp Leu Val Gly Lys Ser Leu Tyr Val 
    290                 295                 300                 


Ser Ala Thr Val Ile Leu His Ser Gly Ser Asp Met Val Gln Ala Glu 
305                 310                 315                 320 


Arg Ser Gly Ile Pro Ile Val Thr Ser Pro Tyr Gln Ile His Phe Thr 
                325                 330                 335     


Lys Thr Pro Lys Tyr Phe Lys Pro Gly Met Pro Phe Asp Leu Met Val 
            340                 345                 350         


Phe Val Thr Asn Pro Asp Gly Ser Pro Ala Tyr Arg Val Pro Val Ala 
        355                 360                 365             


Val Gln Gly Glu Asp Thr Val Gln Ser Leu Thr Gln Gly Asp Gly Val 
    370                 375                 380                 


Ala Lys Leu Ser Ile Asn Thr His Pro Ser Gln Lys Pro Leu Ser Ile 
385                 390                 395                 400 


Thr Val Arg Thr Lys Lys Gln Glu Leu Ser Glu Ala Glu Gln Ala Thr 
                405                 410                 415     


Arg Thr Met Gln Ala Leu Pro Tyr Ser Thr Val Gly Asn Ser Asn Asn 
            420                 425                 430         


Tyr Leu His Leu Ser Val Leu Arg Thr Glu Leu Arg Pro Gly Glu Thr 
        435                 440                 445             


Leu Asn Val Asn Phe Leu Leu Arg Met Asp Arg Ala His Glu Ala Lys 
    450                 455                 460                 


Ile Arg Tyr Tyr Thr Tyr Leu Ile Met Asn Lys Gly Arg Leu Leu Lys 
465                 470                 475                 480 


Ala Gly Arg Gln Val Arg Glu Pro Gly Gln Asp Leu Val Val Leu Pro 
                485                 490                 495     


Leu Ser Ile Thr Thr Asp Phe Ile Pro Ser Phe Arg Leu Val Ala Tyr 
            500                 505                 510         


Tyr Thr Leu Ile Gly Ala Ser Gly Gln Arg Glu Val Val Ala Asp Ser 
        515                 520                 525             


Val Trp Val Asp Val Lys Asp Ser Cys Val Gly Ser Leu Val Val Lys 
    530                 535                 540                 


Ser Gly Gln Ser Glu Asp Arg Gln Pro Val Pro Gly Gln Gln Met Thr 
545                 550                 555                 560 


Leu Lys Ile Glu Gly Asp His Gly Ala Arg Val Val Leu Val Ala Val 
                565                 570                 575     


Asp Lys Gly Val Phe Val Leu Asn Lys Lys Asn Lys Leu Thr Gln Ser 
            580                 585                 590         


Lys Ile Trp Asp Val Val Glu Lys Ala Asp Ile Gly Cys Thr Pro Gly 
        595                 600                 605             


Ser Gly Lys Asp Tyr Ala Gly Val Phe Ser Asp Ala Gly Leu Thr Phe 
    610                 615                 620                 


Thr Ser Ser Ser Gly Gln Gln Thr Ala Gln Arg Ala Glu Leu Gln Cys 
625                 630                 635                 640 


Pro Gln Pro Ala Ala Arg Arg Arg Arg Ser Val Gln Leu Thr Glu Lys 
                645                 650                 655     


Arg Met Asp Lys Val Gly Lys Tyr Pro Lys Glu Leu Arg Lys Cys Cys 
            660                 665                 670         


Glu Asp Gly Met Arg Glu Asn Pro Met Arg Phe Ser Cys Gln Arg Arg 
        675                 680                 685             


Thr Arg Phe Ile Ser Leu Gly Glu Ala Cys Lys Lys Val Phe Leu Asp 
    690                 695                 700                 


Cys Cys Asn Tyr Ile Thr Glu Leu Arg Arg Gln His Ala Arg Ala Ser 
705                 710                 715                 720 


His Leu Gly Leu Ala Arg Ser Asn Leu Asp Glu Asp Ile Ile Ala Glu 
                725                 730                 735     


Glu Asn Ile Val Ser Arg Ser Glu Phe Pro Glu Ser Trp Leu Trp Asn 
            740                 745                 750         


Val Glu Asp Leu Lys Glu Pro Pro Lys Asn Gly Ile Ser Thr Lys Leu 
        755                 760                 765             


Met Asn Ile Phe Leu Lys Asp Ser Ile Thr Thr Trp Glu Ile Leu Ala 
    770                 775                 780                 


Val Ser Met Ser Asp Lys Lys Gly Ile Cys Val Ala Asp Pro Phe Glu 
785                 790                 795                 800 


Val Thr Val Met Gln Asp Phe Phe Ile Asp Leu Arg Leu Pro Tyr Ser 
                805                 810                 815     


Val Val Arg Asn Glu Gln Val Glu Ile Arg Ala Val Leu Tyr Asn Tyr 
            820                 825                 830         


Arg Gln Asn Gln Glu Leu Lys Val Arg Val Glu Leu Leu His Asn Pro 
        835                 840                 845             


Ala Phe Cys Ser Leu Ala Thr Thr Lys Arg Arg His Gln Gln Thr Val 
    850                 855                 860                 


Thr Ile Pro Pro Lys Ser Ser Leu Ser Val Pro Tyr Val Ile Val Pro 
865                 870                 875                 880 


Leu Lys Thr Gly Leu Gln Glu Val Glu Val Lys Ala Ala Val Tyr His 
                885                 890                 895     


His Phe Ile Ser Asp Gly Val Arg Lys Ser Leu Lys Val Val Pro Glu 
            900                 905                 910         


Gly Ile Arg Met Asn Lys Thr Val Ala Val Arg Thr Leu Asp Pro Glu 
        915                 920                 925             


Arg Leu Gly Arg Glu Gly Val Gln Lys Glu Asp Ile Pro Pro Ala Asp 
    930                 935                 940                 


Leu Ser Asp Gln Val Pro Asp Thr Glu Ser Glu Thr Arg Ile Leu Leu 
945                 950                 955                 960 


Gln Gly Thr Pro Val Ala Gln Met Thr Glu Asp Ala Val Asp Ala Glu 
                965                 970                 975     


Arg Leu Lys His Leu Ile Val Thr Pro Ser Gly Cys Gly Glu Gln Asn 
            980                 985                 990         


Met Ile Gly Met Thr Pro Thr Val  Ile Ala Val His Tyr  Leu Asp Glu 
        995                 1000                 1005             


Thr Glu  Gln Trp Glu Lys Phe  Gly Leu Glu Lys Arg  Gln Gly Ala 
    1010                 1015                 1020             


Leu Glu  Leu Ile Lys Lys Gly  Tyr Thr Gln Gln Leu  Ala Phe Arg 
    1025                 1030                 1035             


Gln Pro  Ser Ser Ala Phe Ala  Ala Phe Val Lys Arg  Ala Pro Ser 
    1040                 1045                 1050             


Thr Trp  Leu Thr Ala Tyr Val  Val Lys Val Phe Ser  Leu Ala Val 
    1055                 1060                 1065             


Asn Leu  Ile Ala Ile Asp Ser  Gln Val Leu Cys Gly  Ala Val Lys 
    1070                 1075                 1080             


Trp Leu  Ile Leu Glu Lys Gln  Lys Pro Asp Gly Val  Phe Gln Glu 
    1085                 1090                 1095             


Asp Ala  Pro Val Ile His Gln  Glu Met Ile Gly Gly  Leu Arg Asn 
    1100                 1105                 1110             


Asn Asn  Glu Lys Asp Met Ala  Leu Thr Ala Phe Val  Leu Ile Ser 
    1115                 1120                 1125             


Leu Gln  Glu Ala Lys Asp Ile  Cys Glu Glu Gln Val  Asn Ser Leu 
    1130                 1135                 1140             


Pro Gly  Ser Ile Thr Lys Ala  Gly Asp Phe Leu Glu  Ala Asn Tyr 
    1145                 1150                 1155             


Met Asn  Leu Gln Arg Ser Tyr  Thr Val Ala Ile Ala  Gly Tyr Ala 
    1160                 1165                 1170             


Leu Ala  Gln Met Gly Arg Leu  Lys Gly Pro Leu Leu  Asn Lys Phe 
    1175                 1180                 1185             


Leu Thr  Thr Ala Lys Asp Lys  Asn Arg Trp Glu Asp  Pro Gly Lys 
    1190                 1195                 1200             


Gln Leu  Tyr Asn Val Glu Ala  Thr Ser Tyr Ala Leu  Leu Ala Leu 
    1205                 1210                 1215             


Leu Gln  Leu Lys Asp Phe Asp  Phe Val Pro Pro Val  Val Arg Trp 
    1220                 1225                 1230             


Leu Asn  Glu Gln Arg Tyr Tyr  Gly Gly Gly Tyr Gly  Ser Thr Gln 
    1235                 1240                 1245             


Ala Thr  Phe Met Val Phe Gln  Ala Leu Ala Gln Tyr  Gln Lys Asp 
    1250                 1255                 1260             


Ala Pro  Asp His Gln Glu Leu  Asn Leu Asp Val Ser  Leu Gln Leu 
    1265                 1270                 1275             


Pro Ser  Arg Ser Ser Lys Ile  Thr His Arg Ile His  Trp Glu Ser 
    1280                 1285                 1290             


Ala Ser  Leu Leu Arg Ser Glu  Glu Thr Lys Glu Asn  Glu Gly Phe 
    1295                 1300                 1305             


Thr Val  Thr Ala Glu Gly Lys  Gly Gln Gly Thr Leu  Ser Val Val 
    1310                 1315                 1320             


Thr Met  Tyr His Ala Lys Ala  Lys Asp Gln Leu Thr  Cys Asn Lys 
    1325                 1330                 1335             


Phe Asp  Leu Lys Val Thr Ile  Lys Pro Ala Pro Glu  Thr Glu Lys 
    1340                 1345                 1350             


Arg Pro  Gln Asp Ala Lys Asn  Thr Met Ile Leu Glu  Ile Cys Thr 
    1355                 1360                 1365             


Arg Tyr  Arg Gly Asp Gln Asp  Ala Thr Met Ser Ile  Leu Asp Ile 
    1370                 1375                 1380             


Ser Met  Met Thr Gly Phe Ala  Pro Asp Thr Asp Asp  Leu Lys Gln 
    1385                 1390                 1395             


Leu Ala  Asn Gly Val Asp Arg  Tyr Ile Ser Lys Tyr  Glu Leu Asp 
    1400                 1405                 1410             


Lys Ala  Phe Ser Asp Arg Asn  Thr Leu Ile Ile Tyr  Leu Asp Lys 
    1415                 1420                 1425             


Val Ser  His Ser Glu Asp Asp  Cys Leu Ala Phe Lys  Val His Gln 
    1430                 1435                 1440             


Tyr Phe  Asn Val Glu Leu Ile  Gln Pro Gly Ala Val  Lys Val Tyr 
    1445                 1450                 1455             


Ala Tyr  Tyr Asn Leu Glu Glu  Ser Cys Thr Arg Phe  Tyr His Pro 
    1460                 1465                 1470             


Glu Lys  Glu Asp Gly Lys Leu  Asn Lys Leu Cys Arg  Asp Glu Leu 
    1475                 1480                 1485             


Cys Arg  Cys Ala Glu Glu Asn  Cys Phe Ile Gln Lys  Ser Asp Asp 
    1490                 1495                 1500             


Lys Val  Thr Leu Glu Glu Arg  Leu Asp Lys Ala Cys  Glu Pro Gly 
    1505                 1510                 1515             


Val Asp  Tyr Val Tyr Lys Thr  Arg Leu Val Lys Val  Gln Leu Ser 
    1520                 1525                 1530             


Asn Asp  Phe Asp Glu Tyr Ile  Met Ala Ile Glu Gln  Thr Ile Lys 
    1535                 1540                 1545             


Ser Gly  Ser Asp Glu Val Gln  Val Gly Gln Gln Arg  Thr Phe Ile 
    1550                 1555                 1560             


Ser Pro  Ile Lys Cys Arg Glu  Ala Leu Lys Leu Glu  Glu Lys Lys 
    1565                 1570                 1575             


His Tyr  Leu Met Trp Gly Leu  Ser Ser Asp Phe Trp  Gly Glu Lys 
    1580                 1585                 1590             


Pro Asn  Leu Ser Tyr Ile Ile  Gly Lys Asp Thr Trp  Val Glu His 
    1595                 1600                 1605             


Trp Pro  Glu Glu Asp Glu Cys  Gln Asp Glu Glu Asn  Gln Lys Gln 
    1610                 1615                 1620             


Cys Gln  Asp Leu Gly Ala Phe  Thr Glu Ser Met Val  Val Phe Gly 
    1625                 1630                 1635             


Cys Pro  Asn 
    1640     


<210>  2
<211>  1635
<212>  PRT
<213>  Mus musculus

<400>  2

Ile Pro Met Tyr Ser Ile Ile Thr Pro Asn Val Leu Arg Leu Glu Ser 
1               5                   10                  15      


Glu Glu Thr Ile Val Leu Glu Ala His Asp Ala Gln Gly Asp Ile Pro 
            20                  25                  30          


Val Thr Val Thr Val Gln Asp Phe Leu Lys Arg Gln Val Leu Thr Ser 
        35                  40                  45              


Glu Lys Thr Val Leu Thr Gly Ala Ser Gly His Leu Arg Ser Val Ser 
    50                  55                  60                  


Ile Lys Ile Pro Ala Ser Lys Glu Phe Asn Ser Asp Lys Glu Gly His 
65                  70                  75                  80  


Lys Tyr Val Thr Val Val Ala Asn Phe Gly Glu Thr Val Val Glu Lys 
                85                  90                  95      


Ala Val Met Val Ser Phe Gln Ser Gly Tyr Leu Phe Ile Gln Thr Asp 
            100                 105                 110         


Lys Thr Ile Tyr Thr Pro Gly Ser Thr Val Leu Tyr Arg Ile Phe Thr 
        115                 120                 125             


Val Asp Asn Asn Leu Leu Pro Val Gly Lys Thr Val Val Ile Leu Ile 
    130                 135                 140                 


Glu Thr Pro Asp Gly Ile Pro Val Lys Arg Asp Ile Leu Ser Ser Asn 
145                 150                 155                 160 


Asn Gln His Gly Ile Leu Pro Leu Ser Trp Asn Ile Pro Glu Leu Val 
                165                 170                 175     


Asn Met Gly Gln Trp Lys Ile Arg Ala Phe Tyr Glu His Ala Pro Lys 
            180                 185                 190         


Gln Ile Phe Ser Ala Glu Phe Glu Val Lys Glu Tyr Val Leu Pro Ser 
        195                 200                 205             


Phe Glu Val Arg Val Glu Pro Thr Glu Thr Phe Tyr Tyr Ile Asp Asp 
    210                 215                 220                 


Pro Asn Gly Leu Glu Val Ser Ile Ile Ala Lys Phe Leu Tyr Gly Lys 
225                 230                 235                 240 


Asn Val Asp Gly Thr Ala Phe Val Ile Phe Gly Val Gln Asp Gly Asp 
                245                 250                 255     


Lys Lys Ile Ser Leu Ala His Ser Leu Thr Arg Val Val Ile Glu Asp 
            260                 265                 270         


Gly Val Gly Asp Ala Val Leu Thr Arg Lys Val Leu Met Glu Gly Val 
        275                 280                 285             


Arg Pro Ser Asn Ala Asp Ala Leu Val Gly Lys Ser Leu Tyr Val Ser 
    290                 295                 300                 


Val Thr Val Ile Leu His Ser Gly Ser Asp Met Val Glu Ala Glu Arg 
305                 310                 315                 320 


Ser Gly Ile Pro Ile Val Thr Ser Pro Tyr Gln Ile His Phe Thr Lys 
                325                 330                 335     


Thr Pro Lys Phe Phe Lys Pro Ala Met Pro Phe Asp Leu Met Val Phe 
            340                 345                 350         


Val Thr Asn Pro Asp Gly Ser Pro Ala Ser Lys Val Leu Val Val Thr 
        355                 360                 365             


Gln Gly Ser Asn Ala Lys Ala Leu Thr Gln Asp Asp Gly Val Ala Lys 
    370                 375                 380                 


Leu Ser Ile Asn Thr Pro Asn Ser Arg Gln Pro Leu Thr Ile Thr Val 
385                 390                 395                 400 


Arg Thr Lys Lys Asp Thr Leu Pro Glu Ser Arg Gln Ala Thr Lys Thr 
                405                 410                 415     


Met Glu Ala His Pro Tyr Ser Thr Met His Asn Ser Asn Asn Tyr Leu 
            420                 425                 430         


His Leu Ser Val Ser Arg Met Glu Leu Lys Pro Gly Asp Asn Leu Asn 
        435                 440                 445             


Val Asn Phe His Leu Arg Thr Asp Pro Gly His Glu Ala Lys Ile Arg 
    450                 455                 460                 


Tyr Tyr Thr Tyr Leu Val Met Asn Lys Gly Lys Leu Leu Lys Ala Gly 
465                 470                 475                 480 


Arg Gln Val Arg Glu Pro Gly Gln Asp Leu Val Val Leu Ser Leu Pro 
                485                 490                 495     


Ile Thr Pro Glu Phe Ile Pro Ser Phe Arg Leu Val Ala Tyr Tyr Thr 
            500                 505                 510         


Leu Ile Gly Ala Ser Gly Gln Arg Glu Val Val Ala Asp Ser Val Trp 
        515                 520                 525             


Val Asp Val Lys Asp Ser Cys Ile Gly Thr Leu Val Val Lys Gly Asp 
    530                 535                 540                 


Pro Arg Asp Asn His Leu Ala Pro Gly Gln Gln Thr Thr Leu Arg Ile 
545                 550                 555                 560 


Glu Gly Asn Gln Gly Ala Arg Val Gly Leu Val Ala Val Asp Lys Gly 
                565                 570                 575     


Val Phe Val Leu Asn Lys Lys Asn Lys Leu Thr Gln Ser Lys Ile Trp 
            580                 585                 590         


Asp Val Val Glu Lys Ala Asp Ile Gly Cys Thr Pro Gly Ser Gly Lys 
        595                 600                 605             


Asn Tyr Ala Gly Val Phe Met Asp Ala Gly Leu Ala Phe Lys Thr Ser 
    610                 615                 620                 


Gln Gly Leu Gln Thr Glu Gln Arg Ala Asp Leu Glu Cys Thr Lys Pro 
625                 630                 635                 640 


Ala Ala Ser Val Gln Leu Met Glu Arg Arg Met Asp Lys Ala Gly Gln 
                645                 650                 655     


Tyr Thr Asp Lys Gly Leu Arg Lys Cys Cys Glu Asp Gly Met Arg Asp 
            660                 665                 670         


Ile Pro Met Arg Tyr Ser Cys Gln Arg Arg Ala Arg Leu Ile Thr Gln 
        675                 680                 685             


Gly Glu Asn Cys Ile Lys Ala Phe Ile Asp Cys Cys Asn His Ile Thr 
    690                 695                 700                 


Lys Leu Arg Glu Gln His Arg Arg Asp His Val Leu Gly Leu Ala Arg 
705                 710                 715                 720 


Ser Glu Leu Glu Glu Asp Ile Ile Pro Glu Glu Asp Ile Ile Ser Arg 
                725                 730                 735     


Ser His Phe Pro Gln Ser Trp Leu Trp Thr Ile Glu Glu Leu Lys Glu 
            740                 745                 750         


Pro Glu Lys Asn Gly Ile Ser Thr Lys Val Met Asn Ile Phe Leu Lys 
        755                 760                 765             


Asp Ser Ile Thr Thr Trp Glu Ile Leu Ala Val Ser Leu Ser Asp Lys 
    770                 775                 780                 


Lys Gly Ile Cys Val Ala Asp Pro Tyr Glu Ile Arg Val Met Gln Asp 
785                 790                 795                 800 


Phe Phe Ile Asp Leu Arg Leu Pro Tyr Ser Val Val Arg Asn Glu Gln 
                805                 810                 815     


Val Glu Ile Arg Ala Val Leu Phe Asn Tyr Arg Glu Gln Glu Glu Leu 
            820                 825                 830         


Lys Val Arg Val Glu Leu Leu His Asn Pro Ala Phe Cys Ser Met Ala 
        835                 840                 845             


Thr Ala Lys Asn Arg Tyr Phe Gln Thr Ile Lys Ile Pro Pro Lys Ser 
    850                 855                 860                 


Ser Val Ala Val Pro Tyr Val Ile Val Pro Leu Lys Ile Gly Gln Gln 
865                 870                 875                 880 


Glu Val Glu Val Lys Ala Ala Val Phe Asn His Phe Ile Ser Asp Gly 
                885                 890                 895     


Val Lys Lys Thr Leu Lys Val Val Pro Glu Gly Met Arg Ile Asn Lys 
            900                 905                 910         


Thr Val Ala Ile His Thr Leu Asp Pro Glu Lys Leu Gly Gln Gly Gly 
        915                 920                 925             


Val Gln Lys Val Asp Val Pro Ala Ala Asp Leu Ser Asp Gln Val Pro 
    930                 935                 940                 


Asp Thr Asp Ser Glu Thr Arg Ile Ile Leu Gln Gly Ser Pro Val Val 
945                 950                 955                 960 


Gln Met Ala Glu Asp Ala Val Asp Gly Glu Arg Leu Lys His Leu Ile 
                965                 970                 975     


Val Thr Pro Ala Gly Cys Gly Glu Gln Asn Met Ile Gly Met Thr Pro 
            980                 985                 990         


Thr Val Ile Ala Val His Tyr Leu  Asp Gln Thr Glu Gln  Trp Glu Lys 
        995                 1000                 1005             


Phe Gly  Ile Glu Lys Arg Gln  Glu Ala Leu Glu Leu  Ile Lys Lys 
    1010                 1015                 1020             


Gly Tyr  Thr Gln Gln Leu Ala  Phe Lys Gln Pro Ser  Ser Ala Tyr 
    1025                 1030                 1035             


Ala Ala  Phe Asn Asn Arg Pro  Pro Ser Thr Trp Leu  Thr Ala Tyr 
    1040                 1045                 1050             


Val Val  Lys Val Phe Ser Leu  Ala Ala Asn Leu Ile  Ala Ile Asp 
    1055                 1060                 1065             


Ser His  Val Leu Cys Gly Ala  Val Lys Trp Leu Ile  Leu Glu Lys 
    1070                 1075                 1080             


Gln Lys  Pro Asp Gly Val Phe  Gln Glu Asp Gly Pro  Val Ile His 
    1085                 1090                 1095             


Gln Glu  Met Ile Gly Gly Phe  Arg Asn Ala Lys Glu  Ala Asp Val 
    1100                 1105                 1110             


Ser Leu  Thr Ala Phe Val Leu  Ile Ala Leu Gln Glu  Ala Arg Asp 
    1115                 1120                 1125             


Ile Cys  Glu Gly Gln Val Asn  Ser Leu Pro Gly Ser  Ile Asn Lys 
    1130                 1135                 1140             


Ala Gly  Glu Tyr Ile Glu Ala  Ser Tyr Met Asn Leu  Gln Arg Pro 
    1145                 1150                 1155             


Tyr Thr  Val Ala Ile Ala Gly  Tyr Ala Leu Ala Leu  Met Asn Lys 
    1160                 1165                 1170             


Leu Glu  Glu Pro Tyr Leu Gly  Lys Phe Leu Asn Thr  Ala Lys Asp 
    1175                 1180                 1185             


Arg Asn  Arg Trp Glu Glu Pro  Asp Gln Gln Leu Tyr  Asn Val Glu 
    1190                 1195                 1200             


Ala Thr  Ser Tyr Ala Leu Leu  Ala Leu Leu Leu Leu  Lys Asp Phe 
    1205                 1210                 1215             


Asp Ser  Val Pro Pro Val Val  Arg Trp Leu Asn Glu  Gln Arg Tyr 
    1220                 1225                 1230             


Tyr Gly  Gly Gly Tyr Gly Ser  Thr Gln Ala Thr Phe  Met Val Phe 
    1235                 1240                 1245             


Gln Ala  Leu Ala Gln Tyr Gln  Thr Asp Val Pro Asp  His Lys Asp 
    1250                 1255                 1260             


Leu Asn  Met Asp Val Ser Phe  His Leu Pro Ser Arg  Ser Ser Ala 
    1265                 1270                 1275             


Thr Thr  Phe Arg Leu Leu Trp  Glu Asn Gly Asn Leu  Leu Arg Ser 
    1280                 1285                 1290             


Glu Glu  Thr Lys Gln Asn Glu  Ala Phe Ser Leu Thr  Ala Lys Gly 
    1295                 1300                 1305             


Lys Gly  Arg Gly Thr Leu Ser  Val Val Ala Val Tyr  His Ala Lys 
    1310                 1315                 1320             


Leu Lys  Ser Lys Val Thr Cys  Lys Lys Phe Asp Leu  Arg Val Ser 
    1325                 1330                 1335             


Ile Arg  Pro Ala Pro Glu Thr  Ala Lys Lys Pro Glu  Glu Ala Lys 
    1340                 1345                 1350             


Asn Thr  Met Phe Leu Glu Ile  Cys Thr Lys Tyr Leu  Gly Asp Val 
    1355                 1360                 1365             


Asp Ala  Thr Met Ser Ile Leu  Asp Ile Ser Met Met  Thr Gly Phe 
    1370                 1375                 1380             


Ala Pro  Asp Thr Lys Asp Leu  Glu Leu Leu Ala Ser  Gly Val Asp 
    1385                 1390                 1395             


Arg Tyr  Ile Ser Lys Tyr Glu  Met Asn Lys Ala Phe  Ser Asn Lys 
    1400                 1405                 1410             


Asn Thr  Leu Ile Ile Tyr Leu  Glu Lys Ile Ser His  Thr Glu Glu 
    1415                 1420                 1425             


Asp Cys  Leu Thr Phe Lys Val  His Gln Tyr Phe Asn  Val Gly Leu 
    1430                 1435                 1440             


Ile Gln  Pro Gly Ser Val Lys  Val Tyr Ser Tyr Tyr  Asn Leu Glu 
    1445                 1450                 1455             


Glu Ser  Cys Thr Arg Phe Tyr  His Pro Glu Lys Asp  Asp Gly Met 
    1460                 1465                 1470             


Leu Ser  Lys Leu Cys His Ser  Glu Met Cys Arg Cys  Ala Glu Glu 
    1475                 1480                 1485             


Asn Cys  Phe Met Gln Gln Ser  Gln Glu Lys Ile Asn  Leu Asn Val 
    1490                 1495                 1500             


Arg Leu  Asp Lys Ala Cys Glu  Pro Gly Val Asp Tyr  Val Tyr Lys 
    1505                 1510                 1515             


Thr Glu  Leu Thr Asn Ile Glu  Leu Leu Asp Asp Phe  Asp Glu Tyr 
    1520                 1525                 1530             


Thr Met  Thr Ile Gln Gln Val  Ile Lys Ser Gly Ser  Asp Glu Val 
    1535                 1540                 1545             


Gln Ala  Gly Gln Gln Arg Lys  Phe Ile Ser His Ile  Lys Cys Arg 
    1550                 1555                 1560             


Asn Ala  Leu Lys Leu Gln Lys  Gly Lys Lys Tyr Leu  Met Trp Gly 
    1565                 1570                 1575             


Leu Ser  Ser Asp Leu Trp Gly  Glu Lys Pro Asn Thr  Ser Tyr Ile 
    1580                 1585                 1590             


Ile Gly  Lys Asp Thr Trp Val  Glu His Trp Pro Glu  Ala Glu Glu 
    1595                 1600                 1605             


Cys Gln  Asp Gln Lys Tyr Gln  Lys Gln Cys Glu Glu  Leu Gly Ala 
    1610                 1615                 1620             


Phe Thr  Glu Ser Met Val Val  Tyr Gly Cys Pro Asn  
    1625                 1630                 1635 


<210>  3
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  3

Glu Asp Leu Cys Arg Ala Pro Asp Gly Lys Lys Gly Glu Ala Gly Arg 
1               5                   10                  15      


Pro Gly Arg Arg Gly Arg Pro Gly Leu Lys Gly Glu Gln Gly Glu Pro 
            20                  25                  30          


Gly Ala Pro Gly Ile Arg Thr Gly Ile Gln Gly Leu Lys Gly Asp Gln 
        35                  40                  45              


Gly Glu Pro Gly Pro Ser Gly Asn Pro Gly Lys Val Gly Tyr Pro Gly 
    50                  55                  60                  


Pro Ser Gly Pro Leu Gly Ala Arg Gly Ile Pro Gly Ile Lys Gly Thr 
65                  70                  75                  80  


Lys Gly Ser Pro Gly Asn Ile Lys Asp Gln Pro Arg Pro Ala Phe Ser 
                85                  90                  95      


Ala Ile Arg Arg Asn Pro Pro Met Gly Gly Asn Val Val Ile Phe Asp 
            100                 105                 110         


Thr Val Ile Thr Asn Gln Glu Glu Pro Tyr Gln Asn His Ser Gly Arg 
        115                 120                 125             


Phe Val Cys Thr Val Pro Gly Tyr Tyr Tyr Phe Thr Phe Gln Val Leu 
    130                 135                 140                 


Ser Gln Trp Glu Ile Cys Leu Ser Ile Val Ser Ser Ser Arg Gly Gln 
145                 150                 155                 160 


Val Arg Arg Ser Leu Gly Phe Cys Asp Thr Thr Asn Lys Gly Leu Phe 
                165                 170                 175     


Gln Val Val Ser Gly Gly Met Val Leu Gln Leu Gln Gln Gly Asp Gln 
            180                 185                 190         


Val Trp Val Glu Lys Asp Pro Lys Lys Gly His Ile Tyr Gln Gly Ser 
        195                 200                 205             


Glu Ala Asp Ser Val Phe Ser Gly Phe Leu Ile Phe Pro Ser Ala 
    210                 215                 220             


<210>  4
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  4

Gln Leu Ser Cys Thr Gly Pro Pro Ala Ile Pro Gly Ile Pro Gly Ile 
1               5                   10                  15      


Pro Gly Thr Pro Gly Pro Asp Gly Gln Pro Gly Thr Pro Gly Ile Lys 
            20                  25                  30          


Gly Glu Lys Gly Leu Pro Gly Leu Ala Gly Asp His Gly Glu Phe Gly 
        35                  40                  45              


Glu Lys Gly Asp Pro Gly Ile Pro Gly Asn Pro Gly Lys Val Gly Pro 
    50                  55                  60                  


Lys Gly Pro Met Gly Pro Lys Gly Gly Pro Gly Ala Pro Gly Ala Pro 
65                  70                  75                  80  


Gly Pro Lys Gly Glu Ser Gly Asp Tyr Lys Ala Thr Gln Lys Ile Ala 
                85                  90                  95      


Phe Ser Ala Thr Arg Thr Ile Asn Val Pro Leu Arg Arg Asp Gln Thr 
            100                 105                 110         


Ile Arg Phe Asp His Val Ile Thr Asn Met Asn Asn Asn Tyr Glu Pro 
        115                 120                 125             


Arg Ser Gly Lys Phe Thr Cys Lys Val Pro Gly Leu Tyr Tyr Phe Thr 
    130                 135                 140                 


Tyr His Ala Ser Ser Arg Gly Asn Leu Cys Val Asn Leu Met Arg Gly 
145                 150                 155                 160 


Arg Glu Arg Ala Gln Lys Val Val Thr Phe Cys Asp Tyr Ala Tyr Asn 
                165                 170                 175     


Thr Phe Gln Val Thr Thr Gly Gly Met Val Leu Lys Leu Glu Gln Gly 
            180                 185                 190         


Glu Asn Val Phe Leu Gln Ala Thr Asp Lys Asn Ser Leu Leu Gly Met 
        195                 200                 205             


Glu Gly Ala Asn Ser Ile Phe Ser Gly Phe Leu Leu Phe Pro Asp Met 
    210                 215                 220                 


Glu Ala 
225     


<210>  5
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  5

Asn Thr Gly Cys Tyr Gly Ile Pro Gly Met Pro Gly Leu Pro Gly Ala 
1               5                   10                  15      


Pro Gly Lys Asp Gly Tyr Asp Gly Leu Pro Gly Pro Lys Gly Glu Pro 
            20                  25                  30          


Gly Ile Pro Ala Ile Pro Gly Ile Arg Gly Pro Lys Gly Gln Lys Gly 
        35                  40                  45              


Glu Pro Gly Leu Pro Gly His Pro Gly Lys Asn Gly Pro Met Gly Pro 
    50                  55                  60                  


Pro Gly Met Pro Gly Val Pro Gly Pro Met Gly Ile Pro Gly Glu Pro 
65                  70                  75                  80  


Gly Glu Glu Gly Arg Tyr Lys Gln Lys Phe Gln Ser Val Phe Thr Val 
                85                  90                  95      


Thr Arg Gln Thr His Gln Pro Pro Ala Pro Asn Ser Leu Ile Arg Phe 
            100                 105                 110         


Asn Ala Val Leu Thr Asn Pro Gln Gly Asp Tyr Asp Thr Ser Thr Gly 
        115                 120                 125             


Lys Phe Thr Cys Lys Val Pro Gly Leu Tyr Tyr Phe Val Tyr His Ala 
    130                 135                 140                 


Ser His Thr Ala Asn Leu Cys Val Leu Leu Tyr Arg Ser Gly Val Lys 
145                 150                 155                 160 


Val Val Thr Phe Cys Gly His Thr Ser Lys Thr Asn Gln Val Asn Ser 
                165                 170                 175     


Gly Gly Val Leu Leu Arg Leu Gln Val Gly Glu Glu Val Trp Leu Ala 
            180                 185                 190         


Val Asn Asp Tyr Tyr Asp Met Val Gly Ile Gln Gly Ser Asp Ser Val 
        195                 200                 205             


Phe Ser Gly Phe Leu Leu Phe Pro Asp 
    210                 215         


<210>  6
<211>  767
<212>  PRT
<213>  Homo sapiens

<400>  6

Asn Val Asn Phe Gln Lys Ala Ile Asn Glu Lys Leu Gly Gln Tyr Ala 
1               5                   10                  15      


Ser Pro Thr Ala Lys Arg Cys Cys Gln Asp Gly Val Thr Arg Leu Pro 
            20                  25                  30          


Met Met Arg Ser Cys Glu Gln Arg Ala Ala Arg Val Gln Gln Pro Asp 
        35                  40                  45              


Cys Arg Glu Pro Phe Leu Ser Cys Cys Gln Phe Ala Glu Ser Leu Arg 
    50                  55                  60                  


Lys Lys Ser Arg Asp Lys Gly Gln Ala Gly Leu Gln Arg Ala Leu Glu 
65                  70                  75                  80  


Ile Leu Gln Glu Glu Asp Leu Ile Asp Glu Asp Asp Ile Pro Val Arg 
                85                  90                  95      


Ser Phe Phe Pro Glu Asn Trp Leu Trp Arg Val Glu Thr Val Asp Arg 
            100                 105                 110         


Phe Gln Ile Leu Thr Leu Trp Leu Pro Asp Ser Leu Thr Thr Trp Glu 
        115                 120                 125             


Ile His Gly Leu Ser Leu Ser Lys Thr Lys Gly Leu Cys Val Ala Thr 
    130                 135                 140                 


Pro Val Gln Leu Arg Val Phe Arg Glu Phe His Leu His Leu Arg Leu 
145                 150                 155                 160 


Pro Met Ser Val Arg Arg Phe Glu Gln Leu Glu Leu Arg Pro Val Leu 
                165                 170                 175     


Tyr Asn Tyr Leu Asp Lys Asn Leu Thr Val Ser Val His Val Ser Pro 
            180                 185                 190         


Val Glu Gly Leu Cys Leu Ala Gly Gly Gly Gly Leu Ala Gln Gln Val 
        195                 200                 205             


Leu Val Pro Ala Gly Ser Ala Arg Pro Val Ala Phe Ser Val Val Pro 
    210                 215                 220                 


Thr Ala Ala Ala Ala Val Ser Leu Lys Val Val Ala Arg Gly Ser Phe 
225                 230                 235                 240 


Glu Phe Pro Val Gly Asp Ala Val Ser Lys Val Leu Gln Ile Glu Lys 
                245                 250                 255     


Glu Gly Ala Ile His Arg Glu Glu Leu Val Tyr Glu Leu Asn Pro Leu 
            260                 265                 270         


Asp His Arg Gly Arg Thr Leu Glu Ile Pro Gly Asn Ser Asp Pro Asn 
        275                 280                 285             


Met Ile Pro Asp Gly Asp Phe Asn Ser Tyr Val Arg Val Thr Ala Ser 
    290                 295                 300                 


Asp Pro Leu Asp Thr Leu Gly Ser Glu Gly Ala Leu Ser Pro Gly Gly 
305                 310                 315                 320 


Val Ala Ser Leu Leu Arg Leu Pro Arg Gly Cys Gly Glu Gln Thr Met 
                325                 330                 335     


Ile Tyr Leu Ala Pro Thr Leu Ala Ala Ser Arg Tyr Leu Asp Lys Thr 
            340                 345                 350         


Glu Gln Trp Ser Thr Leu Pro Pro Glu Thr Lys Asp His Ala Val Asp 
        355                 360                 365             


Leu Ile Gln Lys Gly Tyr Met Arg Ile Gln Gln Phe Arg Lys Ala Asp 
    370                 375                 380                 


Gly Ser Tyr Ala Ala Trp Leu Ser Arg Asp Ser Ser Thr Trp Leu Thr 
385                 390                 395                 400 


Ala Phe Val Leu Lys Val Leu Ser Leu Ala Gln Glu Gln Val Gly Gly 
                405                 410                 415     


Ser Pro Glu Lys Leu Gln Glu Thr Ser Asn Trp Leu Leu Ser Gln Gln 
            420                 425                 430         


Gln Ala Asp Gly Ser Phe Gln Asp Pro Cys Pro Val Leu Asp Arg Ser 
        435                 440                 445             


Met Gln Gly Gly Leu Val Gly Asn Asp Glu Thr Val Ala Leu Thr Ala 
    450                 455                 460                 


Phe Val Thr Ile Ala Leu His His Gly Leu Ala Val Phe Gln Asp Glu 
465                 470                 475                 480 


Gly Ala Glu Pro Leu Lys Gln Arg Val Glu Ala Ser Ile Ser Lys Ala 
                485                 490                 495     


Asn Ser Phe Leu Gly Glu Lys Ala Ser Ala Gly Leu Leu Gly Ala His 
            500                 505                 510         


Ala Ala Ala Ile Thr Ala Tyr Ala Leu Thr Leu Thr Lys Ala Pro Val 
        515                 520                 525             


Asp Leu Leu Gly Val Ala His Asn Asn Leu Met Ala Met Ala Gln Glu 
    530                 535                 540                 


Thr Gly Asp Asn Leu Tyr Trp Gly Ser Val Thr Gly Ser Gln Ser Asn 
545                 550                 555                 560 


Ala Val Ser Pro Thr Pro Ala Pro Arg Asn Pro Ser Asp Pro Met Pro 
                565                 570                 575     


Gln Ala Pro Ala Leu Trp Ile Glu Thr Thr Ala Tyr Ala Leu Leu His 
            580                 585                 590         


Leu Leu Leu His Glu Gly Lys Ala Glu Met Ala Asp Gln Ala Ser Ala 
        595                 600                 605             


Trp Leu Thr Arg Gln Gly Ser Phe Gln Gly Gly Phe Arg Ser Thr Gln 
    610                 615                 620                 


Asp Thr Val Ile Ala Leu Asp Ala Leu Ser Ala Tyr Trp Ile Ala Ser 
625                 630                 635                 640 


His Thr Thr Glu Glu Arg Gly Leu Asn Val Thr Leu Ser Ser Thr Gly 
                645                 650                 655     


Arg Asn Gly Phe Lys Ser His Ala Leu Gln Leu Asn Asn Arg Gln Ile 
            660                 665                 670         


Arg Gly Leu Glu Glu Glu Leu Gln Phe Ser Leu Gly Ser Lys Ile Asn 
        675                 680                 685             


Val Lys Val Gly Gly Asn Ser Lys Gly Thr Leu Lys Val Leu Arg Thr 
    690                 695                 700                 


Tyr Asn Val Leu Asp Met Lys Asn Thr Thr Cys Gln Asp Leu Gln Ile 
705                 710                 715                 720 


Glu Val Thr Val Lys Gly His Val Glu Tyr Thr Met Glu Ala Asn Glu 
                725                 730                 735     


Asp Tyr Glu Asp Tyr Glu Tyr Asp Glu Leu Pro Ala Lys Asp Asp Pro 
            740                 745                 750         


Asp Ala Pro Leu Gln Pro Val Thr Pro Leu Gln Leu Phe Glu Gly 
        755                 760                 765         


<210>  7
<211>  656
<212>  PRT
<213>  Homo sapiens

<400>  7

Lys Pro Arg Leu Leu Leu Phe Ser Pro Ser Val Val His Leu Gly Val 
1               5                   10                  15      


Pro Leu Ser Val Gly Val Gln Leu Gln Asp Val Pro Arg Gly Gln Val 
            20                  25                  30          


Val Lys Gly Ser Val Phe Leu Arg Asn Pro Ser Arg Asn Asn Val Pro 
        35                  40                  45              


Cys Ser Pro Lys Val Asp Phe Thr Leu Ser Ser Glu Arg Asp Phe Ala 
    50                  55                  60                  


Leu Leu Ser Leu Gln Val Pro Leu Lys Asp Ala Lys Ser Cys Gly Leu 
65                  70                  75                  80  


His Gln Leu Leu Arg Gly Pro Glu Val Gln Leu Val Ala His Ser Pro 
                85                  90                  95      


Trp Leu Lys Asp Ser Leu Ser Arg Thr Thr Asn Ile Gln Gly Ile Asn 
            100                 105                 110         


Leu Leu Phe Ser Ser Arg Arg Gly His Leu Phe Leu Gln Thr Asp Gln 
        115                 120                 125             


Pro Ile Tyr Asn Pro Gly Gln Arg Val Arg Tyr Arg Val Phe Ala Leu 
    130                 135                 140                 


Asp Gln Lys Met Arg Pro Ser Thr Asp Thr Ile Thr Val Met Val Glu 
145                 150                 155                 160 


Asn Ser His Gly Leu Arg Val Arg Lys Lys Glu Val Tyr Met Pro Ser 
                165                 170                 175     


Ser Ile Phe Gln Asp Asp Phe Val Ile Pro Asp Ile Ser Glu Pro Gly 
            180                 185                 190         


Thr Trp Lys Ile Ser Ala Arg Phe Ser Asp Gly Leu Glu Ser Asn Ser 
        195                 200                 205             


Ser Thr Gln Phe Glu Val Lys Lys Tyr Val Leu Pro Asn Phe Glu Val 
    210                 215                 220                 


Lys Ile Thr Pro Gly Lys Pro Tyr Ile Leu Thr Val Pro Gly His Leu 
225                 230                 235                 240 


Asp Glu Met Gln Leu Asp Ile Gln Ala Arg Tyr Ile Tyr Gly Lys Pro 
                245                 250                 255     


Val Gln Gly Val Ala Tyr Val Arg Phe Gly Leu Leu Asp Glu Asp Gly 
            260                 265                 270         


Lys Lys Thr Phe Phe Arg Gly Leu Glu Ser Gln Thr Lys Leu Val Asn 
        275                 280                 285             


Gly Gln Ser His Ile Ser Leu Ser Lys Ala Glu Phe Gln Asp Ala Leu 
    290                 295                 300                 


Glu Lys Leu Asn Met Gly Ile Thr Asp Leu Gln Gly Leu Arg Leu Tyr 
305                 310                 315                 320 


Val Ala Ala Ala Ile Ile Glu Ser Pro Gly Gly Glu Met Glu Glu Ala 
                325                 330                 335     


Glu Leu Thr Ser Trp Tyr Phe Val Ser Ser Pro Phe Ser Leu Asp Leu 
            340                 345                 350         


Ser Lys Thr Lys Arg His Leu Val Pro Gly Ala Pro Phe Leu Leu Gln 
        355                 360                 365             


Ala Leu Val Arg Glu Met Ser Gly Ser Pro Ala Ser Gly Ile Pro Val 
    370                 375                 380                 


Lys Val Ser Ala Thr Val Ser Ser Pro Gly Ser Val Pro Glu Val Gln 
385                 390                 395                 400 


Asp Ile Gln Gln Asn Thr Asp Gly Ser Gly Gln Val Ser Ile Pro Ile 
                405                 410                 415     


Ile Ile Pro Gln Thr Ile Ser Glu Leu Gln Leu Ser Val Ser Ala Gly 
            420                 425                 430         


Ser Pro His Pro Ala Ile Ala Arg Leu Thr Val Ala Ala Pro Pro Ser 
        435                 440                 445             


Gly Gly Pro Gly Phe Leu Ser Ile Glu Arg Pro Asp Ser Arg Pro Pro 
    450                 455                 460                 


Arg Val Gly Asp Thr Leu Asn Leu Asn Leu Arg Ala Val Gly Ser Gly 
465                 470                 475                 480 


Ala Thr Phe Ser His Tyr Tyr Tyr Met Ile Leu Ser Arg Gly Gln Ile 
                485                 490                 495     


Val Phe Met Asn Arg Glu Pro Lys Arg Thr Leu Thr Ser Val Ser Val 
            500                 505                 510         


Phe Val Asp His His Leu Ala Pro Ser Phe Tyr Phe Val Ala Phe Tyr 
        515                 520                 525             


Tyr His Gly Asp His Pro Val Ala Asn Ser Leu Arg Val Asp Val Gln 
    530                 535                 540                 


Ala Gly Ala Cys Glu Gly Lys Leu Glu Leu Ser Val Asp Gly Ala Lys 
545                 550                 555                 560 


Gln Tyr Arg Asn Gly Glu Ser Val Lys Leu His Leu Glu Thr Asp Ser 
                565                 570                 575     


Leu Ala Leu Val Ala Leu Gly Ala Leu Asp Thr Ala Leu Tyr Ala Ala 
            580                 585                 590         


Gly Ser Lys Ser His Lys Pro Leu Asn Met Gly Lys Val Phe Glu Ala 
        595                 600                 605             


Met Asn Ser Tyr Asp Leu Gly Cys Gly Pro Gly Gly Gly Asp Ser Ala 
    610                 615                 620                 


Leu Gln Val Phe Gln Ala Ala Gly Leu Ala Phe Ser Asp Gly Asp Gln 
625                 630                 635                 640 


Trp Thr Leu Ser Arg Lys Arg Leu Ser Cys Pro Lys Glu Lys Thr Thr 
                645                 650                 655     


<210>  8
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  8

Glu Ala Pro Lys Val Val Glu Glu Gln Glu Ser Arg Val His Tyr Thr 
1               5                   10                  15      


Val Cys Ile Trp Arg Asn Gly Lys Val Gly Leu Ser Gly Met Ala Ile 
            20                  25                  30          


Ala Asp Val Thr Leu Leu Ser Gly Phe His Ala Leu Arg Ala Asp Leu 
        35                  40                  45              


Glu Lys Leu Thr Ser Leu Ser Asp Arg Tyr Val Ser His Phe Glu Thr 
    50                  55                  60                  


Glu Gly Pro His Val Leu Leu Tyr Phe Asp Ser Val Pro Thr Ser Arg 
65                  70                  75                  80  


Glu Cys Val Gly Phe Glu Ala Val Gln Glu Val Pro Val Gly Leu Val 
                85                  90                  95      


Gln Pro Ala Ser Ala Thr Leu Tyr Asp Tyr Tyr Asn Pro Glu Arg Arg 
            100                 105                 110         


Cys Ser Val Phe Tyr Gly Ala Pro Ser Lys Ser Arg Leu Leu Ala Thr 
        115                 120                 125             


Leu Cys Ser Ala Glu Val Cys Gln Cys Ala Glu Gly Lys Cys Pro Arg 
    130                 135                 140                 


Gln Arg Arg Ala Leu Glu Arg Gly Leu Gln Asp Glu Asp Gly Tyr Arg 
145                 150                 155                 160 


Met Lys Phe Ala Cys Tyr Tyr Pro Arg Val Glu Tyr Gly Phe Gln Val 
                165                 170                 175     


Lys Val Leu Arg Glu Asp Ser Arg Ala Ala Phe Arg Leu Phe Glu Thr 
            180                 185                 190         


Lys Ile Thr Gln Val Leu His Phe Thr Lys Asp Val Lys Ala Ala Ala 
        195                 200                 205             


Asn Gln Met Arg Asn Phe Leu Val Arg Ala Ser Cys Arg Leu Arg Leu 
    210                 215                 220                 


Glu Pro Gly Lys Glu Tyr Leu Ile Met Gly Leu Asp Gly Ala Thr Tyr 
225                 230                 235                 240 


Asp Leu Glu Gly His Pro Gln Tyr Leu Leu Asp Ser Asn Ser Trp Ile 
                245                 250                 255     


Glu Glu Met Pro Ser Glu Arg Leu Cys Arg Ser Thr Arg Gln Arg Ala 
            260                 265                 270         


Ala Cys Ala Gln Leu Asn Asp Phe Leu Gln Glu Tyr Gly Thr Gln Gly 
        275                 280                 285             


Cys Gln Val 
    290     


<210>  9
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  9

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asn Gln Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Asn Ser Asp Gly Gly Leu Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Pro Gly Gly Pro Thr Met Tyr Gly Ser Arg Trp Cys Asp 
            100                 105                 110         


Ser Arg Leu Phe Tyr Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  10
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  CDR1

<400>  10

Gly Phe Thr Leu Asn Gln Tyr Ala Ile Gly 
1               5                   10  


<210>  11
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  CDR2

<400>  11

Cys Ile Ser Asn Ser Asp Gly Gly Leu Tyr 
1               5                   10  


<210>  12
<211>  20
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  CDR3

<400>  12

Asp Pro Gly Gly Pro Thr Met Tyr Gly Ser Arg Trp Cys Asp Ser Arg 
1               5                   10                  15      


Leu Phe Tyr Ser 
            20  


<210>  13
<211>  125
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(125)
<223>  IF75

<400>  13

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Asp 
            20                  25                  30          


Val Met Ala Trp Phe Arg Gln Ala Pro Gly Thr Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Leu Ile Thr Ala Gly Gly Gly Thr His Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Val Ile Ser Arg Asp Asn Asp Lys Asn Met Ala Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Gly 
                85                  90                  95      


Ala Asp Glu Asn Pro Pro Gly Trp Pro Ser Arg Trp Ser Ser Ala Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  14
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  CDR1

<400>  14

Gly Arg Thr Phe Asn Asn Asp Val Met Ala 
1               5                   10  


<210>  15
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  CDR2

<400>  15

Leu Ile Thr Ala Gly Gly Gly Thr His 
1               5                   


<210>  16
<211>  17
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR3

<400>  16

Asp Glu Asn Pro Pro Gly Trp Pro Ser Arg Trp Ser Ser Ala Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  17
<211>  128
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(128)
<223>  IF78

<400>  17

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Asp Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Trp Thr Phe Arg Asp Ser 
            20                  25                  30          


Met Tyr Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Ser Trp Arg Gly Gly Ser Thr Leu Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Gln Cys Ala Ala Asp Thr Ser Ala Arg Ala Ala Leu Tyr Ser Thr Gly 
            100                 105                 110         


Tyr Glu Tyr Asp His Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  18
<211>  12
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  CDR1

<400>  18

Gly Trp Thr Phe Arg Asp Ser Met Tyr Asn Met Gly 
1               5                   10          


<210>  19
<211>  11
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  CDR2

<400>  19

Ala Ile Ser Trp Arg Gly Gly Ser Thr Leu Tyr 
1               5                   10      


<210>  20
<211>  17
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR3

<400>  20

Asp Thr Ser Ala Arg Ala Ala Leu Tyr Ser Thr Gly Tyr Glu Tyr Asp 
1               5                   10                  15      


His 
    


<210>  21
<211>  127
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(127)
<223>  IH31

<400>  21

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Ser Asp His 
            20                  25                  30          


Ile Thr Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ser Ile Asn Trp Ser Gly Ser Arg Ala Tyr Tyr Ala Asp Ser Asp 
    50                  55                  60                  


Lys Arg Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Ser 
65                  70                  75                  80  


Leu Gln Thr Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Lys Phe Ala Asp Ile Ser Asp Ala Tyr Tyr His His Gln Thr 
            100                 105                 110         


Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  22
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  CDR1

<400>  22

Gly Arg Thr Ser Ser Asp His Ile Thr Ala 
1               5                   10  


<210>  23
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  CDR2

<400>  23

Ser Ile Asn Trp Ser Gly Ser Arg Ala Tyr 
1               5                   10  


<210>  24
<211>  18
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(18)
<223>  CDR3

<400>  24

Lys Phe Ala Asp Ile Ser Asp Ala Tyr Tyr His His Gln Thr Asp Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  25
<211>  119
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(119)
<223>  IH33

<400>  25

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Asp Ser Ile Ala 
            20                  25                  30          


Ala Ile Ile Trp Tyr Arg Gln Thr Pro Glu Asn Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Thr Ser Gly Val Asn Thr Asn Tyr Ala Ala Pro Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Lys 
                85                  90                  95      


Ala Ala Val Val Met Gly Pro Ser Thr Thr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  26
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  CDR1

<400>  26

Gly Ser Thr Asp Ser Ile Ala Ala Ile Ile 
1               5                   10  


<210>  27
<211>  7
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  CDR2

<400>  27

Gly Ile Thr Ser Gly Val Asn 
1               5           


<210>  28
<211>  11
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  CDR3

<400>  28

Ala Val Val Met Gly Pro Ser Thr Thr Asp Tyr 
1               5                   10      


<210>  29
<211>  124
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(124)
<223>  IH35

<400>  29

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Val Ala Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Leu Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ala Gly Asp Gly Ser Pro Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Ser Arg Trp Ser Asn Cys Ala Trp Asp Tyr Tyr Gly Met Asp 
            100                 105                 110         


Pro Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  30
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  CDR1

<400>  30

Gly Phe Ser Phe Asp Asp Tyr Ala Ile Gly 
1               5                   10  


<210>  31
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  CDR2

<400>  31

Cys Ile Ser Ala Gly Asp Gly Ser Pro Gln 
1               5                   10  


<210>  32
<211>  15
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  CDR3

<400>  32

Ser Arg Trp Ser Asn Cys Ala Trp Asp Tyr Tyr Gly Met Asp Pro 
1               5                   10                  15  


<210>  33
<211>  125
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(125)
<223>  IH37

<400>  33

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gln Gly Ser Gly Arg Thr Phe Asn Asn Asp 
            20                  25                  30          


Val Leu Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Tyr Val 
        35                  40                  45              


Ala Met Ile Thr Ser Gly Gly Asn Pro Phe Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Val Ile Ser Arg Asp Asn Asp Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Glu Asn Pro Pro Gly Trp Pro Ser Arg Trp Ser Ser Ala Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  34
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  CDR1

<400>  34

Gly Arg Thr Phe Asn Asn Asp Val Leu Ala 
1               5                   10  


<210>  35
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  CDR2

<400>  35

Met Ile Thr Ser Gly Gly Asn Pro Phe 
1               5                   


<210>  36
<211>  17
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR3

<400>  36

Asp Glu Asn Pro Pro Gly Trp Pro Ser Arg Trp Ser Ser Ala Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  37
<211>  124
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(124)
<223>  IH39

<400>  37

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Tyr Gly Val Ala Ser Val Thr Thr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ser Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Gly Pro Ser Gly Gly Thr His Tyr Gly Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Asp Cys Ala 
                85                  90                  95      


Ala Asp Leu Arg Gly Gly Gly Met Trp Ala Ser Ser Gly Arg Tyr Glu 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  38
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  CDR1

<400>  38

Gly Val Ala Ser Val Thr Thr Val Met Gly 
1               5                   10  


<210>  39
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  CDR2

<400>  39

Ala Ile Gly Pro Ser Gly Gly Thr His 
1               5                   


<210>  40
<211>  16
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  CDR3

<400>  40

Asp Leu Arg Gly Gly Gly Met Trp Ala Ser Ser Gly Arg Tyr Glu Tyr 
1               5                   10                  15      


<210>  41
<211>  124
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(124)
<223>  hC4bNb6

<400>  41

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Arg Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Leu Gly Arg Tyr 
            20                  25                  30          


Ser Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Gln Phe Val 
        35                  40                  45              


Ala Ala Ile Asn Trp Ser Gly Gly Ser Thr Tyr Tyr Pro Asp Phe Ala 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Gly Met Asp Ile Glu Ile Thr Arg Ala Asn Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  42
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  CDR1

<400>  42

Gly Arg Thr Leu Gly Arg Tyr Ser Met Ala 
1               5                   10  


<210>  43
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  CDR2

<400>  43

Ala Ile Asn Trp Ser Gly Gly Ser Thr Tyr 
1               5                   10  


<210>  44
<211>  15
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  CDR3

<400>  44

Gly Gly Met Asp Ile Glu Ile Thr Arg Ala Asn Glu Tyr Asp Tyr 
1               5                   10                  15  


<210>  45
<211>  124
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(124)
<223>  hC4Nb8

<400>  45

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Asn Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Leu Tyr 
65                  70                  75                  80  


Leu Arg Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Gly Pro Glu Val Glu Ile Thr Arg Ala Asn Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  46
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  CDR1

<400>  46

Gly Arg Thr Phe Ser Arg Tyr Ala Met Gly 
1               5                   10  


<210>  47
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  CDR2

<400>  47

Ala Ile Asn Trp Ser Gly Gly Ser Thr Tyr 
1               5                   10  


<210>  48
<211>  15
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  CDR3

<400>  48

Gly Gly Pro Glu Val Glu Ile Thr Arg Ala Asn Glu Tyr Asp Tyr 
1               5                   10                  15  


<210>  49
<211>  118
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(118)
<223>  D121

<400>  49

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Val Ser Gly Ser Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Ala Gly Glu Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Tyr Ser Thr Gly Arg Thr Asn Tyr Ile Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Leu Gly Ala Thr Thr Met Ile Asn Thr Lys Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  50
<211>  11
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  CDR1

<400>  50

Ser Gly Ser Thr Phe Ser Asp Tyr Ala Met Gly 
1               5                   10      


<210>  51
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  CDR2

<400>  51

Ala Ile Tyr Ser Thr Gly Arg Thr Asn 
1               5                   


<210>  52
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  CDR3

<400>  52

Leu Gly Ala Thr Thr Met Ile Asn Thr Lys 
1               5                   10  


<210>  53
<211>  128
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(128)
<223>  DI62

<400>  53

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asp Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Leu Ser Thr Gly Gly Ser Phe Thr Arg Tyr Ala Ala Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Gln Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Phe Thr Pro Tyr Gly Thr Asn Trp Ser Arg Phe Arg Glu 
            100                 105                 110         


Ala Arg Asp His Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  54
<211>  11
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  CDR1

<400>  54

Ser Gly Arg Thr Phe Ser Asp Tyr Thr Met Gly 
1               5                   10      


<210>  55
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  CDR2

<400>  55

Gly Leu Ser Thr Gly Gly Ser Phe Thr Arg 
1               5                   10  


<210>  56
<211>  19
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  CDR3

<400>  56

Asp Phe Thr Pro Tyr Gly Thr Asn Trp Ser Arg Phe Arg Glu Ala Arg 
1               5                   10                  15      


Asp His Tyr 
            


<210>  57
<211>  127
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(127)
<223>  EWE-hC3Nb1

<400>  57

Met Glu Trp Glu Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val 
1               5                   10                  15      


Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile 
            20                  25                  30          


Phe Ser Ile Asn Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
        35                  40                  45              


Arg Glu Phe Val Ala Thr Ile Asn Arg Ser Gly Gly Arg Thr Tyr Tyr 
    50                  55                  60                  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys 
65                  70                  75                  80  


Asn Met Val Tyr Leu Gln Met His Ser Leu Lys Pro Glu Asp Thr Ala 
                85                  90                  95      


Ile Tyr Tyr Cys Ala Ala Gly Thr Gly Trp Ser Pro Gln Thr Asp Asn 
            100                 105                 110         


Glu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  58
<211>  11
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  CDR1

<400>  58

Ser Gly Ser Ile Phe Ser Ile Asn Ala Met Gly 
1               5                   10      


<210>  59
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  CDR2

<400>  59

Thr Ile Asn Arg Ser Gly Gly Arg Thr Tyr 
1               5                   10  


<210>  60
<211>  14
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3

<400>  60

Gly Thr Gly Trp Ser Pro Gln Thr Asp Asn Glu Tyr Asn Tyr 
1               5                   10                  


<210>  61
<211>  358
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(358)
<223>  IgG-Fc-hC3Nb1

<400>  61

Ala Pro Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
1               5                   10                  15      


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    50                  55                  60                  


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                85                  90                  95      


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            100                 105                 110         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    130                 135                 140                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                165                 170                 175     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            180                 185                 190         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        195                 200                 205             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    210                 215                 220                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ala Gln Val Gln Leu Val 
225                 230                 235                 240 


Glu Thr Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser 
                245                 250                 255     


Cys Ala Ala Ser Gly Ser Ile Phe Ser Ile Asn Ala Met Gly Trp Phe 
            260                 265                 270         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Thr Ile Asn Arg 
        275                 280                 285             


Ser Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
    290                 295                 300                 


Ile Ser Arg Asp Asn Gly Lys Asn Met Val Tyr Leu Gln Met His Ser 
305                 310                 315                 320 


Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala Gly Thr Gly 
                325                 330                 335     


Trp Ser Pro Gln Thr Asp Asn Glu Tyr Asn Tyr Trp Gly Gln Gly Thr 
            340                 345                 350         


Gln Val Thr Val Ser Ser 
        355             


<210>  62
<211>  11
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  CDR1

<400>  62

Ser Gly Ser Ile Phe Ser Ile Asn Ala Met Gly 
1               5                   10      


<210>  63
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  CDR2

<400>  63

Thr Ile Asn Arg Ser Gly Gly Arg Thr Tyr 
1               5                   10  


<210>  64
<211>  14
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3

<400>  64

Gly Thr Gly Trp Ser Pro Gln Thr Asp Asn Glu Tyr Asn Tyr 
1               5                   10                  


<210>  65
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  polypeptide linker

<400>  65

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  66
<211>  129
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(129)
<223>  hC4Nb5

<400>  66

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Lys Asn 
            20                  25                  30          


Pro Met Ala Trp Phe Arg Gln Pro Pro Gly Gln Glu Arg Asp Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Asp Ser Thr Asn Tyr Ala Asn Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Gln Arg Thr Val Ser 
65                  70                  75                  80  


Leu Ser Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Gly Arg Thr Asp Tyr Ser Pro Asn Ser Leu Ala Leu Thr 
            100                 105                 110         


Ala Gln Asn Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  67
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  CDR1

<400>  67

Gly Arg Thr Phe Asn Lys Asn Pro Met Ala 
1               5                   10  


<210>  68
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  CDR2

<400>  68

Ala Ile Ser Trp Ser Gly Asp Ser Thr Asn 
1               5                   10  


<210>  69
<211>  19
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  CDR3

<400>  69

Val Gly Arg Thr Asp Tyr Ser Pro Asn Ser Leu Ala Leu Thr Ala Gln 
1               5                   10                  15      


Asn Tyr Asp 
            


<210>  70
<211>  124
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(124)
<223>  hC4Nb4

<400>  70

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Glu Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Ala Ala Ser Gly Arg Tyr Ala Met Gly Trp 
            20                  25                  30          


Phe Arg Gln Ala Pro Gly Asn Glu Arg Asp Phe Val Ala Ala Ile Ser 
        35                  40                  45              


Arg Ser Gly Asp Ser Ala Asn Tyr Ala Asp Thr Ala Trp Gly Arg Phe 
    50                  55                  60                  


Thr Ile Ser Arg Asp Asn Ala Gln Asn Thr Met Thr Leu Gln Met Asn 
65                  70                  75                  80  


Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Lys Ala 
                85                  90                  95      


Gly Leu Tyr Ser Leu Asn Ser Leu Phe Leu Arg Ser Gln Glu Tyr Thr 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  71
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  CDR1

<400>  71

Gly Arg Tyr Ala Met Gly 
1               5       


<210>  72
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  CDR2

<400>  72

Ala Ile Ser Arg Ser Gly Asp Ser Ala Asn 
1               5                   10  


<210>  73
<211>  19
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  CDR3

<400>  73

Lys Ala Gly Leu Tyr Ser Leu Asn Ser Leu Phe Leu Arg Ser Gln Glu 
1               5                   10                  15      


Tyr Thr Tyr 
            


<210>  74
<211>  148
<212>  PRT
<213>  Mus musculus

<400>  74

Glu Asn Cys Phe Met Gln Gln Ser Gln Glu Lys Ile Asn Leu Asn Val 
1               5                   10                  15      


Arg Leu Asp Lys Ala Cys Glu Pro Gly Val Asp Tyr Val Tyr Lys Thr 
            20                  25                  30          


Glu Leu Thr Asn Ile Glu Leu Leu Asp Asp Phe Asp Glu Tyr Thr Met 
        35                  40                  45              


Thr Ile Gln Gln Val Ile Lys Ser Gly Ser Asp Glu Val Gln Ala Gly 
    50                  55                  60                  


Gln Gln Arg Lys Phe Ile Ser His Ile Lys Cys Arg Asn Ala Leu Lys 
65                  70                  75                  80  


Leu Gln Lys Gly Lys Lys Tyr Leu Met Trp Gly Leu Ser Ser Asp Leu 
                85                  90                  95      


Trp Gly Glu Lys Pro Asn Thr Ser Tyr Ile Ile Gly Lys Asp Thr Trp 
            100                 105                 110         


Val Glu His Trp Pro Glu Ala Glu Glu Cys Gln Asp Gln Lys Tyr Gln 
        115                 120                 125             


Lys Gln Cys Glu Glu Leu Gly Ala Phe Thr Glu Ser Met Val Val Tyr 
    130                 135                 140                 


Gly Cys Pro Asn 
145             


<210>  75
<211>  45
<212>  PRT
<213>  Mus musculus

<400>  75

Glu Lys Ile Asn Leu Asn Val Arg Leu Asp Lys Ala Cys Pro Glu Ala 
1               5                   10                  15      


Glu Glu Cys Gln Asp Gln Lys Tyr Gln Lys Gln Cys Glu Glu Leu Gly 
            20                  25                  30          


Ala Phe Thr Glu Ser Met Val Val Tyr Gly Cys Pro Asn 
        35                  40                  45  


<210>  76
<211>  126
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(126)
<223>  pNSL270

<400>  76

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Ala Ser Thr Leu Asp Ile Tyr 
            20                  25                  30          


Thr Tyr Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Arg Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Ser Arg Asn Gly Tyr Ser Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Lys Leu Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Ala Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Asp Arg Thr Thr Glu Val Val Asp Arg Glu Asp Asp 
            100                 105                 110         


Tyr Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  77
<211>  12
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  CDR1

<400>  77

Ala Ser Thr Leu Asp Ile Tyr Thr Tyr Ala Met Ala 
1               5                   10          


<210>  78
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  CDR2

<400>  78

Ala Ile Ser Arg Asn Gly Tyr Ser Thr Tyr 
1               5                   10  


<210>  79
<211>  15
<212>  PRT
<213>  Unknown

<220>
<223>  Artificial sequence/unknown


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  CDR3

<400>  79

Asp Arg Thr Thr Glu Val Val Asp Arg Glu Asp Asp Tyr Gly Tyr 
1               5                   10                  15  


<210>  80
<211>  767
<212>  PRT
<213>  Homo sapiens

<400>  80

Asn Val Asn Phe Gln Lys Ala Ile Asn Glu Lys Leu Gly Gln Tyr Ala 
1               5                   10                  15      


Ser Pro Thr Ala Lys Arg Cys Cys Gln Asp Gly Val Thr Arg Leu Pro 
            20                  25                  30          


Met Met Arg Ser Cys Glu Gln Arg Ala Ala Arg Val Gln Gln Pro Asp 
        35                  40                  45              


Cys Arg Glu Pro Phe Leu Ser Cys Cys Gln Phe Ala Glu Ser Leu Arg 
    50                  55                  60                  


Lys Lys Ser Arg Asp Lys Gly Gln Ala Gly Leu Gln Arg Ala Leu Glu 
65                  70                  75                  80  


Ile Leu Gln Glu Glu Asp Leu Ile Asp Glu Asp Asp Ile Pro Val Arg 
                85                  90                  95      


Ser Phe Phe Pro Glu Asn Trp Leu Trp Arg Val Glu Thr Val Asp Arg 
            100                 105                 110         


Phe Gln Ile Leu Thr Leu Trp Leu Pro Asp Ser Leu Thr Thr Trp Glu 
        115                 120                 125             


Ile His Gly Leu Ser Leu Ser Lys Thr Lys Gly Leu Cys Val Ala Thr 
    130                 135                 140                 


Pro Val Gln Leu Arg Val Phe Arg Glu Phe His Leu His Leu Arg Leu 
145                 150                 155                 160 


Pro Met Ser Val Arg Arg Phe Glu Gln Leu Glu Leu Arg Pro Val Leu 
                165                 170                 175     


Tyr Asn Tyr Leu Asp Lys Asn Leu Thr Val Ser Val His Val Ser Pro 
            180                 185                 190         


Val Glu Gly Leu Cys Leu Ala Gly Gly Gly Gly Leu Ala Gln Gln Val 
        195                 200                 205             


Leu Val Pro Ala Gly Ser Ala Arg Pro Val Ala Phe Ser Val Val Pro 
    210                 215                 220                 


Thr Ala Ala Thr Ala Val Ser Leu Lys Val Val Ala Arg Gly Ser Phe 
225                 230                 235                 240 


Glu Phe Pro Val Gly Asp Ala Val Ser Lys Val Leu Gln Ile Glu Lys 
                245                 250                 255     


Glu Gly Ala Ile His Arg Glu Glu Leu Val Tyr Glu Leu Asn Pro Leu 
            260                 265                 270         


Asp His Arg Gly Arg Thr Leu Glu Ile Pro Gly Asn Ser Asp Pro Asn 
        275                 280                 285             


Met Ile Pro Asp Gly Asp Phe Asn Ser Tyr Val Arg Val Thr Ala Ser 
    290                 295                 300                 


Asp Pro Leu Asp Thr Leu Gly Ser Glu Gly Ala Leu Ser Pro Gly Gly 
305                 310                 315                 320 


Val Ala Ser Leu Leu Arg Leu Pro Arg Gly Cys Gly Glu Gln Thr Met 
                325                 330                 335     


Ile Tyr Leu Ala Pro Thr Leu Ala Ala Ser Arg Tyr Leu Asp Lys Thr 
            340                 345                 350         


Glu Gln Trp Ser Thr Leu Pro Pro Glu Thr Lys Asp His Ala Val Asp 
        355                 360                 365             


Leu Ile Gln Lys Gly Tyr Met Arg Ile Gln Gln Phe Arg Lys Ala Asp 
    370                 375                 380                 


Gly Ser Tyr Ala Ala Trp Leu Ser Arg Gly Ser Ser Thr Trp Leu Thr 
385                 390                 395                 400 


Ala Phe Val Leu Lys Val Leu Ser Leu Ala Gln Glu Gln Val Gly Gly 
                405                 410                 415     


Ser Pro Glu Lys Leu Gln Glu Thr Ser Asn Trp Leu Leu Ser Gln Gln 
            420                 425                 430         


Gln Ala Asp Gly Ser Phe Gln Asp Leu Ser Pro Val Ile His Arg Ser 
        435                 440                 445             


Met Gln Gly Gly Leu Val Gly Asn Asp Glu Thr Val Ala Leu Thr Ala 
    450                 455                 460                 


Phe Val Thr Ile Ala Leu His His Gly Leu Ala Val Phe Gln Asp Glu 
465                 470                 475                 480 


Gly Ala Glu Pro Leu Lys Gln Arg Val Glu Ala Ser Ile Ser Lys Ala 
                485                 490                 495     


Ser Ser Phe Leu Gly Glu Lys Ala Ser Ala Gly Leu Leu Gly Ala His 
            500                 505                 510         


Ala Ala Ala Ile Thr Ala Tyr Ala Leu Thr Leu Thr Lys Ala Pro Ala 
        515                 520                 525             


Asp Leu Arg Gly Val Ala His Asn Asn Leu Met Ala Met Ala Gln Glu 
    530                 535                 540                 


Thr Gly Asp Asn Leu Tyr Trp Gly Ser Val Thr Gly Ser Gln Ser Asn 
545                 550                 555                 560 


Ala Val Ser Pro Thr Pro Ala Pro Arg Asn Pro Ser Asp Pro Met Pro 
                565                 570                 575     


Gln Ala Pro Ala Leu Trp Ile Glu Thr Thr Ala Tyr Ala Leu Leu His 
            580                 585                 590         


Leu Leu Leu His Glu Gly Lys Ala Glu Met Ala Asp Gln Ala Ala Ala 
        595                 600                 605             


Trp Leu Thr Arg Gln Gly Ser Phe Gln Gly Gly Phe Arg Ser Thr Gln 
    610                 615                 620                 


Asp Thr Val Ile Ala Leu Asp Ala Leu Ser Ala Tyr Trp Ile Ala Ser 
625                 630                 635                 640 


His Thr Thr Glu Glu Arg Gly Leu Asn Val Thr Leu Ser Ser Thr Gly 
                645                 650                 655     


Arg Asn Gly Phe Lys Ser His Ala Leu Gln Leu Asn Asn Arg Gln Ile 
            660                 665                 670         


Arg Gly Leu Glu Glu Glu Leu Gln Phe Ser Leu Gly Ser Lys Ile Asn 
        675                 680                 685             


Val Lys Val Gly Gly Asn Ser Lys Gly Thr Leu Lys Val Leu Arg Thr 
    690                 695                 700                 


Tyr Asn Val Leu Asp Met Lys Asn Thr Thr Cys Gln Asp Leu Gln Ile 
705                 710                 715                 720 


Glu Val Thr Val Lys Gly His Val Glu Tyr Thr Met Glu Ala Asn Glu 
                725                 730                 735     


Asp Tyr Glu Asp Tyr Glu Tyr Asp Glu Leu Pro Ala Lys Asp Asp Pro 
            740                 745                 750         


Asp Ala Pro Leu Gln Pro Val Thr Pro Leu Gln Leu Phe Glu Gly 
        755                 760                 765         


<210>  81
<211>  690
<212>  PRT
<213>  Homo sapiens

<400>  81

Ala Leu Glu Ile Leu Gln Glu Glu Asp Leu Ile Asp Glu Asp Asp Ile 
1               5                   10                  15      


Pro Val Arg Ser Phe Phe Pro Glu Asn Trp Leu Trp Arg Val Glu Thr 
            20                  25                  30          


Val Asp Arg Phe Gln Ile Leu Thr Leu Trp Leu Pro Asp Ser Leu Thr 
        35                  40                  45              


Thr Trp Glu Ile His Gly Leu Ser Leu Ser Lys Thr Lys Gly Leu Cys 
    50                  55                  60                  


Val Ala Thr Pro Val Gln Leu Arg Val Phe Arg Glu Phe His Leu His 
65                  70                  75                  80  


Leu Arg Leu Pro Met Ser Val Arg Arg Phe Glu Gln Leu Glu Leu Arg 
                85                  90                  95      


Pro Val Leu Tyr Asn Tyr Leu Asp Lys Asn Leu Thr Val Ser Val His 
            100                 105                 110         


Val Ser Pro Val Glu Gly Leu Cys Leu Ala Gly Gly Gly Gly Leu Ala 
        115                 120                 125             


Gln Gln Val Leu Val Pro Ala Gly Ser Ala Arg Pro Val Ala Phe Ser 
    130                 135                 140                 


Val Val Pro Thr Ala Ala Ala Ala Val Ser Leu Lys Val Val Ala Arg 
145                 150                 155                 160 


Gly Ser Phe Glu Phe Pro Val Gly Asp Ala Val Ser Lys Val Leu Gln 
                165                 170                 175     


Ile Glu Lys Glu Gly Ala Ile His Arg Glu Glu Leu Val Tyr Glu Leu 
            180                 185                 190         


Asn Pro Leu Asp His Arg Gly Arg Thr Leu Glu Ile Pro Gly Asn Ser 
        195                 200                 205             


Asp Pro Asn Met Ile Pro Asp Gly Asp Phe Asn Ser Tyr Val Arg Val 
    210                 215                 220                 


Thr Ala Ser Asp Pro Leu Asp Thr Leu Gly Ser Glu Gly Ala Leu Ser 
225                 230                 235                 240 


Pro Gly Gly Val Ala Ser Leu Leu Arg Leu Pro Arg Gly Cys Gly Glu 
                245                 250                 255     


Gln Thr Met Ile Tyr Leu Ala Pro Thr Leu Ala Ala Ser Arg Tyr Leu 
            260                 265                 270         


Asp Lys Thr Glu Gln Trp Ser Thr Leu Pro Pro Glu Thr Lys Asp His 
        275                 280                 285             


Ala Val Asp Leu Ile Gln Lys Gly Tyr Met Arg Ile Gln Gln Phe Arg 
    290                 295                 300                 


Lys Ala Asp Gly Ser Tyr Ala Ala Trp Leu Ser Arg Asp Ser Ser Thr 
305                 310                 315                 320 


Trp Leu Thr Ala Phe Val Leu Lys Val Leu Ser Leu Ala Gln Glu Gln 
                325                 330                 335     


Val Gly Gly Ser Pro Glu Lys Leu Gln Glu Thr Ser Asn Trp Leu Leu 
            340                 345                 350         


Ser Gln Gln Gln Ala Asp Gly Ser Phe Gln Asp Pro Cys Pro Val Leu 
        355                 360                 365             


Asp Arg Ser Met Gln Gly Gly Leu Val Gly Asn Asp Glu Thr Val Ala 
    370                 375                 380                 


Leu Thr Ala Phe Val Thr Ile Ala Leu His His Gly Leu Ala Val Phe 
385                 390                 395                 400 


Gln Asp Glu Gly Ala Glu Pro Leu Lys Gln Arg Val Glu Ala Ser Ile 
                405                 410                 415     


Ser Lys Ala Asn Ser Phe Leu Gly Glu Lys Ala Ser Ala Gly Leu Leu 
            420                 425                 430         


Gly Ala His Ala Ala Ala Ile Thr Ala Tyr Ala Leu Thr Leu Thr Lys 
        435                 440                 445             


Ala Pro Val Asp Leu Leu Gly Val Ala His Asn Asn Leu Met Ala Met 
    450                 455                 460                 


Ala Gln Glu Thr Gly Asp Asn Leu Tyr Trp Gly Ser Val Thr Gly Ser 
465                 470                 475                 480 


Gln Ser Asn Ala Val Ser Pro Thr Pro Ala Pro Arg Asn Pro Ser Asp 
                485                 490                 495     


Pro Met Pro Gln Ala Pro Ala Leu Trp Ile Glu Thr Thr Ala Tyr Ala 
            500                 505                 510         


Leu Leu His Leu Leu Leu His Glu Gly Lys Ala Glu Met Ala Asp Gln 
        515                 520                 525             


Ala Ser Ala Trp Leu Thr Arg Gln Gly Ser Phe Gln Gly Gly Phe Arg 
    530                 535                 540                 


Ser Thr Gln Asp Thr Val Ile Ala Leu Asp Ala Leu Ser Ala Tyr Trp 
545                 550                 555                 560 


Ile Ala Ser His Thr Thr Glu Glu Arg Gly Leu Asn Val Thr Leu Ser 
                565                 570                 575     


Ser Thr Gly Arg Asn Gly Phe Lys Ser His Ala Leu Gln Leu Asn Asn 
            580                 585                 590         


Arg Gln Ile Arg Gly Leu Glu Glu Glu Leu Gln Phe Ser Leu Gly Ser 
        595                 600                 605             


Lys Ile Asn Val Lys Val Gly Gly Asn Ser Lys Gly Thr Leu Lys Val 
    610                 615                 620                 


Leu Arg Thr Tyr Asn Val Leu Asp Met Lys Asn Thr Thr Cys Gln Asp 
625                 630                 635                 640 


Leu Gln Ile Glu Val Thr Val Lys Gly His Val Glu Tyr Thr Met Glu 
                645                 650                 655     


Ala Asn Glu Asp Tyr Glu Asp Tyr Glu Tyr Asp Glu Leu Pro Ala Lys 
            660                 665                 670         


Asp Asp Pro Asp Ala Pro Leu Gln Pro Val Thr Pro Leu Gln Leu Phe 
        675                 680                 685             


Glu Gly 
    690 


<210>  82
<211>  690
<212>  PRT
<213>  Homo sapiens

<400>  82

Ala Leu Glu Ile Leu Gln Glu Glu Asp Leu Ile Asp Glu Asp Asp Ile 
1               5                   10                  15      


Pro Val Arg Ser Phe Phe Pro Glu Asn Trp Leu Trp Arg Val Glu Thr 
            20                  25                  30          


Val Asp Arg Phe Gln Ile Leu Thr Leu Trp Leu Pro Asp Ser Leu Thr 
        35                  40                  45              


Thr Trp Glu Ile His Gly Leu Ser Leu Ser Lys Thr Lys Gly Leu Cys 
    50                  55                  60                  


Val Ala Thr Pro Val Gln Leu Arg Val Phe Arg Glu Phe His Leu His 
65                  70                  75                  80  


Leu Arg Leu Pro Met Ser Val Arg Arg Phe Glu Gln Leu Glu Leu Arg 
                85                  90                  95      


Pro Val Leu Tyr Asn Tyr Leu Asp Lys Asn Leu Thr Val Ser Val His 
            100                 105                 110         


Val Ser Pro Val Glu Gly Leu Cys Leu Ala Gly Gly Gly Gly Leu Ala 
        115                 120                 125             


Gln Gln Val Leu Val Pro Ala Gly Ser Ala Arg Pro Val Ala Phe Ser 
    130                 135                 140                 


Val Val Pro Thr Ala Ala Thr Ala Val Ser Leu Lys Val Val Ala Arg 
145                 150                 155                 160 


Gly Ser Phe Glu Phe Pro Val Gly Asp Ala Val Ser Lys Val Leu Gln 
                165                 170                 175     


Ile Glu Lys Glu Gly Ala Ile His Arg Glu Glu Leu Val Tyr Glu Leu 
            180                 185                 190         


Asn Pro Leu Asp His Arg Gly Arg Thr Leu Glu Ile Pro Gly Asn Ser 
        195                 200                 205             


Asp Pro Asn Met Ile Pro Asp Gly Asp Phe Asn Ser Tyr Val Arg Val 
    210                 215                 220                 


Thr Ala Ser Asp Pro Leu Asp Thr Leu Gly Ser Glu Gly Ala Leu Ser 
225                 230                 235                 240 


Pro Gly Gly Val Ala Ser Leu Leu Arg Leu Pro Arg Gly Cys Gly Glu 
                245                 250                 255     


Gln Thr Met Ile Tyr Leu Ala Pro Thr Leu Ala Ala Ser Arg Tyr Leu 
            260                 265                 270         


Asp Lys Thr Glu Gln Trp Ser Thr Leu Pro Pro Glu Thr Lys Asp His 
        275                 280                 285             


Ala Val Asp Leu Ile Gln Lys Gly Tyr Met Arg Ile Gln Gln Phe Arg 
    290                 295                 300                 


Lys Ala Asp Gly Ser Tyr Ala Ala Trp Leu Ser Arg Gly Ser Ser Thr 
305                 310                 315                 320 


Trp Leu Thr Ala Phe Val Leu Lys Val Leu Ser Leu Ala Gln Glu Gln 
                325                 330                 335     


Val Gly Gly Ser Pro Glu Lys Leu Gln Glu Thr Ser Asn Trp Leu Leu 
            340                 345                 350         


Ser Gln Gln Gln Ala Asp Gly Ser Phe Gln Asp Leu Ser Pro Val Ile 
        355                 360                 365             


His Arg Ser Met Gln Gly Gly Leu Val Gly Asn Asp Glu Thr Val Ala 
    370                 375                 380                 


Leu Thr Ala Phe Val Thr Ile Ala Leu His His Gly Leu Ala Val Phe 
385                 390                 395                 400 


Gln Asp Glu Gly Ala Glu Pro Leu Lys Gln Arg Val Glu Ala Ser Ile 
                405                 410                 415     


Ser Lys Ala Ser Ser Phe Leu Gly Glu Lys Ala Ser Ala Gly Leu Leu 
            420                 425                 430         


Gly Ala His Ala Ala Ala Ile Thr Ala Tyr Ala Leu Thr Leu Thr Lys 
        435                 440                 445             


Ala Pro Ala Asp Leu Arg Gly Val Ala His Asn Asn Leu Met Ala Met 
    450                 455                 460                 


Ala Gln Glu Thr Gly Asp Asn Leu Tyr Trp Gly Ser Val Thr Gly Ser 
465                 470                 475                 480 


Gln Ser Asn Ala Val Ser Pro Thr Pro Ala Pro Arg Asn Pro Ser Asp 
                485                 490                 495     


Pro Met Pro Gln Ala Pro Ala Leu Trp Ile Glu Thr Thr Ala Tyr Ala 
            500                 505                 510         


Leu Leu His Leu Leu Leu His Glu Gly Lys Ala Glu Met Ala Asp Gln 
        515                 520                 525             


Ala Ala Ala Trp Leu Thr Arg Gln Gly Ser Phe Gln Gly Gly Phe Arg 
    530                 535                 540                 


Ser Thr Gln Asp Thr Val Ile Ala Leu Asp Ala Leu Ser Ala Tyr Trp 
545                 550                 555                 560 


Ile Ala Ser His Thr Thr Glu Glu Arg Gly Leu Asn Val Thr Leu Ser 
                565                 570                 575     


Ser Thr Gly Arg Asn Gly Phe Lys Ser His Ala Leu Gln Leu Asn Asn 
            580                 585                 590         


Arg Gln Ile Arg Gly Leu Glu Glu Glu Leu Gln Phe Ser Leu Gly Ser 
        595                 600                 605             


Lys Ile Asn Val Lys Val Gly Gly Asn Ser Lys Gly Thr Leu Lys Val 
    610                 615                 620                 


Leu Arg Thr Tyr Asn Val Leu Asp Met Lys Asn Thr Thr Cys Gln Asp 
625                 630                 635                 640 


Leu Gln Ile Glu Val Thr Val Lys Gly His Val Glu Tyr Thr Met Glu 
                645                 650                 655     


Ala Asn Glu Asp Tyr Glu Asp Tyr Glu Tyr Asp Glu Leu Pro Ala Lys 
            660                 665                 670         


Asp Asp Pro Asp Ala Pro Leu Gln Pro Val Thr Pro Leu Gln Leu Phe 
        675                 680                 685             


Glu Gly 
    690 


<210>  83
<211>  654
<212>  PRT
<213>  Mus musculus

<400>  83

Lys Pro Arg Leu Leu Leu Phe Ser Pro Ser Val Val Asn Leu Gly Thr 
1               5                   10                  15      


Pro Leu Ser Val Gly Val Gln Leu Leu Asp Ala Pro Pro Gly Gln Glu 
            20                  25                  30          


Val Lys Gly Ser Val Phe Leu Arg Asn Pro Lys Gly Gly Ser Cys Ser 
        35                  40                  45              


Pro Lys Lys Asp Phe Lys Leu Ser Ser Gly Asp Asp Phe Val Leu Leu 
    50                  55                  60                  


Ser Leu Glu Val Pro Leu Glu Asp Val Arg Ser Cys Gly Leu Phe Asp 
65                  70                  75                  80  


Leu Arg Arg Ala Pro His Ile Gln Leu Val Ala Gln Ser Pro Trp Leu 
                85                  90                  95      


Arg Asn Thr Ala Phe Lys Ala Thr Glu Thr Gln Gly Val Asn Leu Leu 
            100                 105                 110         


Phe Ser Ser Arg Arg Gly His Ile Phe Val Gln Thr Asp Gln Pro Ile 
        115                 120                 125             


Tyr Asn Pro Gly Gln Arg Val Arg Tyr Arg Val Phe Ala Leu Asp Gln 
    130                 135                 140                 


Lys Met Arg Pro Ser Thr Asp Phe Leu Thr Ile Thr Val Glu Asn Ser 
145                 150                 155                 160 


His Gly Leu Arg Val Leu Lys Lys Glu Ile Phe Thr Ser Thr Ser Ile 
                165                 170                 175     


Phe Gln Asp Ala Phe Thr Ile Pro Asp Ile Ser Glu Pro Gly Thr Trp 
            180                 185                 190         


Lys Ile Ser Ala Arg Phe Ser Asp Gly Leu Glu Ser Asn Arg Ser Thr 
        195                 200                 205             


His Phe Glu Val Lys Lys Tyr Val Leu Pro Asn Phe Glu Val Lys Ile 
    210                 215                 220                 


Thr Pro Trp Lys Pro Tyr Ile Leu Met Val Pro Ser Asn Ser Asp Glu 
225                 230                 235                 240 


Ile Gln Leu Asp Ile Gln Ala Arg Tyr Ile Tyr Gly Lys Pro Val Gln 
                245                 250                 255     


Gly Val Ala Tyr Thr Arg Phe Ala Leu Met Asp Glu Gln Gly Lys Arg 
            260                 265                 270         


Thr Phe Leu Arg Gly Leu Glu Thr Gln Ala Lys Leu Val Glu Gly Arg 
        275                 280                 285             


Thr His Ile Ser Ile Ser Lys Asp Gln Phe Gln Ala Ala Leu Asp Lys 
    290                 295                 300                 


Ile Asn Ile Gly Val Arg Asp Leu Glu Gly Leu Arg Leu Tyr Ala Ala 
305                 310                 315                 320 


Thr Ala Val Ile Glu Ser Pro Gly Gly Glu Met Glu Glu Ala Glu Leu 
                325                 330                 335     


Thr Ser Trp Arg Phe Val Ser Ser Ala Phe Ser Leu Asp Leu Ser Arg 
            340                 345                 350         


Thr Lys Arg His Leu Val Pro Gly Ala His Phe Leu Leu Gln Ala Leu 
        355                 360                 365             


Val Gln Glu Met Ser Gly Ser Glu Ala Ser Asn Val Pro Val Lys Val 
    370                 375                 380                 


Ser Ala Thr Leu Val Ser Gly Ser Asp Ser Gln Val Leu Asp Ile Gln 
385                 390                 395                 400 


Gln Ser Thr Asn Gly Ile Gly Gln Val Ser Ile Ser Phe Pro Ile Pro 
                405                 410                 415     


Pro Thr Val Thr Glu Leu Arg Leu Leu Val Ser Ala Gly Ser Leu Tyr 
            420                 425                 430         


Pro Ala Ile Ala Arg Leu Thr Val Gln Ala Pro Pro Ser Arg Gly Thr 
        435                 440                 445             


Gly Phe Leu Ser Ile Glu Pro Leu Asp Pro Arg Ser Pro Ser Val Gly 
    450                 455                 460                 


Asp Thr Phe Ile Leu Asn Leu Gln Pro Val Gly Ile Pro Ala Pro Thr 
465                 470                 475                 480 


Phe Ser His Tyr Tyr Tyr Met Ile Ile Ser Arg Gly Gln Ile Met Ala 
                485                 490                 495     


Met Gly Arg Glu Pro Arg Lys Thr Val Thr Ser Val Ser Val Leu Val 
            500                 505                 510         


Asp His Gln Leu Ala Pro Ser Phe Tyr Phe Val Ala Tyr Phe Tyr His 
        515                 520                 525             


Gln Gly His Pro Val Ala Asn Ser Leu Leu Ile Asn Ile Gln Ser Arg 
    530                 535                 540                 


Asp Cys Glu Gly Lys Leu Gln Leu Lys Val Asp Gly Ala Lys Glu Tyr 
545                 550                 555                 560 


Arg Asn Ala Asp Met Met Lys Leu Arg Ile Gln Thr Asp Ser Lys Ala 
                565                 570                 575     


Leu Val Ala Leu Gly Ala Val Asp Met Ala Leu Tyr Ala Val Gly Gly 
            580                 585                 590         


Arg Ser His Lys Pro Leu Asp Met Ser Lys Val Phe Glu Val Ile Asn 
        595                 600                 605             


Ser Tyr Asn Val Gly Cys Gly Pro Gly Gly Gly Asp Asp Ala Leu Gln 
    610                 615                 620                 


Val Phe Gln Asp Ala Gly Leu Ala Phe Ser Asp Gly Asp Arg Leu Thr 
625                 630                 635                 640 


Gln Thr Arg Glu Asp Leu Ser Cys Pro Lys Glu Lys Lys Ser 
                645                 650                 


<210>  84
<211>  766
<212>  PRT
<213>  Mus musculus

<400>  84

Asn Val Asn Phe Gln Lys Ala Val Ser Glu Lys Leu Gly Gln Tyr Ser 
1               5                   10                  15      


Ser Pro Asp Ala Lys Arg Cys Cys Gln Asp Gly Met Thr Lys Leu Pro 
            20                  25                  30          


Met Lys Arg Thr Cys Glu Gln Arg Ala Ala Arg Val Pro Gln Gln Ala 
        35                  40                  45              


Cys Arg Glu Pro Phe Leu Ser Cys Cys Lys Phe Ala Glu Asp Leu Arg 
    50                  55                  60                  


Arg Asn Gln Thr Arg Ser Gln Ala His Leu Ala Arg Asn Asn His Asn 
65                  70                  75                  80  


Met Leu Gln Glu Glu Asp Leu Ile Asp Glu Asp Asp Ile Leu Val Arg 
                85                  90                  95      


Thr Ser Phe Pro Glu Asn Trp Leu Trp Arg Val Glu Pro Val Asp Ser 
            100                 105                 110         


Ser Lys Leu Leu Thr Val Trp Leu Pro Asp Ser Met Thr Thr Trp Glu 
        115                 120                 125             


Ile His Gly Val Ser Leu Ser Lys Ser Lys Gly Leu Cys Val Ala Lys 
    130                 135                 140                 


Pro Thr Arg Val Arg Val Phe Arg Lys Phe His Leu His Leu Arg Leu 
145                 150                 155                 160 


Pro Ile Ser Ile Arg Arg Phe Glu Gln Phe Glu Leu Arg Pro Val Leu 
                165                 170                 175     


Tyr Asn Tyr Leu Asn Asp Asp Val Ala Val Ser Val His Val Thr Pro 
            180                 185                 190         


Val Glu Gly Leu Cys Leu Ala Gly Gly Gly Met Met Ala Gln Gln Val 
        195                 200                 205             


Thr Val Pro Ala Gly Ser Ala Arg Pro Val Ala Phe Ser Val Val Pro 
    210                 215                 220                 


Thr Ala Ala Ala Asn Val Pro Leu Lys Val Val Ala Arg Gly Val Phe 
225                 230                 235                 240 


Asp Leu Gly Asp Ala Val Ser Lys Ile Leu Gln Ile Glu Lys Glu Gly 
                245                 250                 255     


Ala Ile His Arg Glu Glu Leu Val Tyr Asn Leu Asp Pro Leu Asn Asn 
            260                 265                 270         


Leu Gly Arg Thr Leu Glu Ile Pro Gly Ser Ser Asp Pro Asn Ile Val 
        275                 280                 285             


Pro Asp Gly Asp Phe Ser Ser Leu Val Arg Val Thr Ala Ser Glu Pro 
    290                 295                 300                 


Leu Glu Thr Met Gly Ser Glu Gly Ala Leu Ser Pro Gly Gly Val Ala 
305                 310                 315                 320 


Ser Leu Leu Arg Leu Pro Gln Gly Cys Ala Glu Gln Thr Met Ile Tyr 
                325                 330                 335     


Leu Ala Pro Thr Leu Thr Ala Ser Asn Tyr Leu Asp Arg Thr Glu Gln 
            340                 345                 350         


Trp Ser Lys Leu Ser Pro Glu Thr Lys Asp His Ala Val Asp Leu Ile 
        355                 360                 365             


Gln Lys Gly Tyr Met Arg Ile Gln Gln Phe Arg Lys Asn Asp Gly Ser 
    370                 375                 380                 


Phe Gly Ala Trp Leu His Arg Asp Ser Ser Thr Trp Leu Thr Ala Phe 
385                 390                 395                 400 


Val Leu Lys Ile Leu Ser Leu Ala Gln Glu Gln Val Gly Asn Ser Pro 
                405                 410                 415     


Glu Lys Leu Gln Glu Thr Ala Ser Trp Leu Leu Ala Gln Gln Leu Gly 
            420                 425                 430         


Asp Gly Ser Phe His Asp Pro Cys Pro Val Ile His Arg Ala Met Gln 
        435                 440                 445             


Gly Gly Leu Val Gly Ser Asp Glu Thr Val Ala Leu Thr Ala Phe Val 
    450                 455                 460                 


Val Ile Ala Leu His His Gly Leu Asp Val Phe Gln Asp Asp Asp Ala 
465                 470                 475                 480 


Lys Gln Leu Lys Asn Arg Val Glu Ala Ser Ile Thr Lys Ala Asn Ser 
                485                 490                 495     


Phe Leu Gly Gln Lys Ala Ser Ala Gly Leu Leu Gly Ala His Ala Ala 
            500                 505                 510         


Ala Ile Thr Ala Tyr Ala Leu Thr Leu Thr Lys Ala Ser Glu Asp Leu 
        515                 520                 525             


Arg Asn Val Ala His Asn Ser Leu Met Ala Met Ala Glu Glu Thr Gly 
    530                 535                 540                 


Glu His Leu Tyr Trp Gly Leu Val Leu Gly Ser Gln Asp Lys Val Val 
545                 550                 555                 560 


Leu Arg Pro Thr Ala Pro Arg Ser Pro Thr Glu Pro Val Pro Gln Ala 
                565                 570                 575     


Pro Ala Leu Trp Ile Glu Thr Thr Ala Tyr Ala Leu Leu His Leu Leu 
            580                 585                 590         


Leu Arg Glu Gly Lys Gly Lys Met Ala Asp Lys Ala Ala Ser Trp Leu 
        595                 600                 605             


Thr His Gln Gly Ser Phe His Gly Ala Phe Arg Ser Thr Gln Asp Thr 
    610                 615                 620                 


Val Val Thr Leu Asp Ala Leu Ser Ala Tyr Trp Ile Ala Ser His Thr 
625                 630                 635                 640 


Thr Glu Glu Lys Ala Leu Asn Val Thr Leu Ser Ser Met Gly Arg Asn 
                645                 650                 655     


Gly Leu Lys Thr His Gly Leu His Leu Asn Asn His Gln Val Lys Gly 
            660                 665                 670         


Leu Glu Glu Glu Leu Lys Phe Ser Leu Gly Ser Thr Ile Ser Val Lys 
        675                 680                 685             


Val Glu Gly Asn Ser Lys Gly Thr Leu Lys Ile Leu Arg Thr Tyr Asn 
    690                 695                 700                 


Val Leu Asp Met Lys Asn Thr Thr Cys Gln Asp Leu Gln Ile Glu Val 
705                 710                 715                 720 


Lys Val Thr Gly Ala Val Glu Tyr Ala Trp Asp Ala Asn Glu Asp Tyr 
                725                 730                 735     


Glu Asp Tyr Tyr Asp Met Pro Ala Ala Asp Asp Pro Ser Val Pro Leu 
            740                 745                 750         


Gln Pro Val Thr Pro Leu Gln Leu Phe Glu Gly Arg Arg Ser 
        755                 760                 765     


<210>  85
<211>  291
<212>  PRT
<213>  Mus musculus

<400>  85

Glu Ala Pro Lys Val Val Glu Glu Gln Glu Ser Arg Val Gln Tyr Thr 
1               5                   10                  15      


Val Cys Ile Trp Arg Asn Gly Lys Leu Gly Leu Ser Gly Met Ala Ile 
            20                  25                  30          


Ala Asp Ile Thr Leu Leu Ser Gly Phe His Ala Leu Arg Ala Asp Leu 
        35                  40                  45              


Glu Lys Leu Thr Ser Leu Ser Asp Arg Tyr Val Ser His Phe Glu Thr 
    50                  55                  60                  


Asp Gly Pro His Val Leu Leu Tyr Phe Asp Ser Val Pro Thr Thr Arg 
65                  70                  75                  80  


Glu Cys Val Gly Phe Gly Ala Ser Gln Glu Val Val Val Gly Leu Val 
                85                  90                  95      


Gln Pro Ser Ser Ala Val Leu Tyr Asp Tyr Tyr Ser Pro Asp His Lys 
            100                 105                 110         


Cys Ser Val Phe Tyr Ala Ala Pro Thr Lys Ser Gln Leu Leu Ala Thr 
        115                 120                 125             


Leu Cys Ser Gly Asp Val Cys Gln Cys Ala Glu Gly Lys Cys Pro Arg 
    130                 135                 140                 


Leu Leu Arg Ser Leu Glu Arg Arg Val Glu Asp Lys Asp Gly Tyr Arg 
145                 150                 155                 160 


Met Arg Phe Ala Cys Tyr Tyr Pro Arg Val Glu Tyr Gly Phe Thr Val 
                165                 170                 175     


Lys Val Leu Arg Glu Asp Gly Arg Ala Ala Phe Arg Leu Phe Glu Ser 
            180                 185                 190         


Lys Ile Thr Gln Val Leu His Phe Arg Lys Asp Thr Met Ala Ser Ile 
        195                 200                 205             


Gly Gln Thr Arg Asn Phe Leu Ser Arg Ala Ser Cys Arg Leu Arg Leu 
    210                 215                 220                 


Glu Pro Asn Lys Glu Tyr Leu Ile Met Gly Met Asp Gly Glu Thr Ser 
225                 230                 235                 240 


Asp Asn Lys Gly Asp Pro Gln Tyr Leu Leu Asp Ser Asn Thr Trp Ile 
                245                 250                 255     


Glu Glu Met Pro Ser Glu Gln Met Cys Lys Ser Thr Arg His Arg Ala 
            260                 265                 270         


Ala Cys Phe Gln Leu Lys Asp Phe Leu Met Glu Phe Ser Ser Arg Gly 
        275                 280                 285             


Cys Gln Val 
    290     


