                         SEQUENCE LISTING

<110>  THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
       Weiner, David B
       Xu, Ziyang
       Wise, Megan
 
<120>  COMPOSITIONS AND METHODS FOR IN VIVO POST TRANSLATIONAL 
       MODIFICATION

<130>  206194-0029-00WO

<150>  US 62/683,344
<151>  2018-06-11

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RheCD4-Ig

<400>  1

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Lys Lys Val Val Leu Gly Lys Lys Gly Asp Thr Val Glu 
            20                  25                  30          


Leu Thr Cys Asn Ala Ser Gln Lys Lys Asn Thr Gln Phe His Trp Lys 
        35                  40                  45              


Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn Gln Gly Ser Phe Leu Thr 
    50                  55                  60                  


Lys Gly Pro Ser Lys Leu Ser Asp Arg Ala Asp Ser Arg Lys Ser Leu 
65                  70                  75                  80  


Trp Asp Gln Gly Cys Phe Ser Met Ile Ile Lys Asn Leu Lys Ile Glu 
                85                  90                  95      


Asp Ser Asp Thr Tyr Ile Cys Glu Val Glu Asn Lys Lys Glu Glu Val 
            100                 105                 110         


Glu Leu Leu Val Phe Gly Leu Thr Ala Asn Ser Asp Thr His Leu Leu 
        115                 120                 125             


Glu Gly Gln Ser Leu Thr Leu Thr Leu Glu Ser Pro Pro Gly Ser Ser 
    130                 135                 140                 


Pro Ser Val Lys Cys Arg Ser Pro Gly Gly Lys Asn Ile Gln Gly Gly 
145                 150                 155                 160 


Arg Thr Ile Ser Val Pro Gln Leu Glu Arg Gln Asp Ser Gly Thr Trp 
                165                 170                 175     


Thr Cys Thr Val Ser Gln Asp Gln Lys Thr Val Glu Phe Lys Ile Asp 
            180                 185                 190         


Ile Val Val Leu Ala Phe Gln Lys Ala Ser Ser Thr Gly Leu Pro Cys 
        195                 200                 205             


Arg Ser Thr Cys Pro Pro Cys Pro Ala Glu Leu Leu Gly Gly Pro Ser 
    210                 215                 220                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
225                 230                 235                 240 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Glu Pro 
                245                 250                 255     


Asp Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            260                 265                 270         


Gln Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
        275                 280                 285             


Ser Val Leu Thr Val Thr His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    290                 295                 300                 


Thr Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Arg Gln Lys Thr 
305                 310                 315                 320 


Val Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                325                 330                 335     


Pro Pro Pro Arg Glu Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
            340                 345                 350         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Val Val Glu Trp Ala Ser 
        355                 360                 365             


Asn Gly Gln Pro Glu Asn Thr Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    370                 375                 380                 


Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
385                 390                 395                 400 


Arg Trp Gln Gln Gly Asn Thr Phe Ser Cys Ser Val Met His Glu Ala 
                405                 410                 415     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Val Ser Pro Gly Lys 
            420                 425                 430         


Gly Gly Gly Gly Gly Asp Tyr Tyr Asp Tyr Asp Gly Gly Tyr Tyr Tyr 
        435                 440                 445             


Asp Met Asp 
    450     


<210>  2
<211>  1377
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RheCD4-Ig

<400>  2
ggatccgcca ccatggactg gacttggaga atcctgttcc tggtcgccgc tgctaccggg       60

actcacgcta aaaaggtcgt gctgggcaaa aagggagata cagtggagct gacctgcaac      120

gcctcccaga agaagaatac acagttccac tggaagaaca gcaatcagat caagatcctg      180

ggcaatcagg gctcctttct gaccaaggga ccaagcaagc tgtccgacag ggcagattct      240

agaaagagcc tgtgggacca gggctgcttc tctatgatca tcaagaacct gaagatcgag      300

gacagcgata cctacatctg tgaggtggag aataagaagg aggaggtgga gctgctggtg      360

tttggcctga cagccaactc cgatacccac ctgctggagg gacagtccct gaccctgaca      420

ctggagtctc cccctggcag ctccccaagc gtgaagtgca ggtcccctgg cggcaagaac      480

atccagggcg gccggacaat cagcgtgcct cagctggagc gccaggactc tggcacctgg      540

acatgtaccg tgagccagga ccagaagacc gtggagttca agatcgatat cgtggtgctg      600

gcctttcaga aggcctctag cacaggcctg ccatgcaggt ctacctgccc accctgtcca      660

gcagagctgc tgggcggccc aagcgtgttc ctgtttcctc caaagcctaa ggacaccctg      720

atgatctcca gaacaccaga ggtgacctgc gtggtggtgg acgtgtctca ggaggagcca      780

gatgtgaagt tcaactggta cgtggatggc gtggaggtgc acaatgccca gacaaagccc      840

agggaggagc agtttaattc tacctacaga gtggtgagcg tgctgacagt gacccaccag      900

gattggctga acggcaagga gtatacatgc aaggtgagca ataaggccct gccagccccc      960

aggcagaaga cagtgtccaa gaccaagggc cagcctcggg agccacaggt gtataccctg     1020

ccccctccac gcgaggagct gacaaagaac caggtgagcc tgacctgtct ggtgaagggc     1080

ttctacccct ccgacatcgt ggtggagtgg gcctctaacg gccagcctga gaatacatat     1140

aagaccacac cccctgtgct ggactccgat ggctcttact tcctgtatag caagctgaca     1200

gtggataagt cccgctggca gcagggcaac accttttcct gttctgtgat gcacgaggcc     1260

ctgcacaatc actataccca gaagagcctg tccgtgtctc ctggcaaggg cggaggaggc     1320

ggagactatt acgactatga cggcggctac tactatgata tggattgata actcgag        1377


<210>  3
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human eCD4-Ig

<400>  3

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Lys Lys Val Val Leu Gly Lys Lys Gly Asp Thr Val Glu 
            20                  25                  30          


Leu Thr Cys Thr Ala Ser Gln Lys Lys Ser Ile Gln Phe His Trp Lys 
        35                  40                  45              


Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn Ala Gly Ser Phe Leu Thr 
    50                  55                  60                  


Lys Gly Pro Ser Lys Leu Asn Asp Arg Ala Asp Ser Arg Arg Ser Leu 
65                  70                  75                  80  


Trp Asp Gln Gly Asn Phe Pro Leu Ile Ile Lys Asn Leu Lys Ile Glu 
                85                  90                  95      


Asp Ser Asp Thr Tyr Ile Cys Glu Val Glu Asp Gln Lys Glu Glu Val 
            100                 105                 110         


Gln Leu Leu Val Phe Gly Leu Thr Ala Asn Ser Asp Thr His Leu Leu 
        115                 120                 125             


Gln Gly Gln Ser Leu Thr Leu Thr Leu Glu Ser Pro Pro Gly Ser Ser 
    130                 135                 140                 


Pro Ser Val Gln Cys Arg Ser Pro Arg Gly Lys Asn Ile Gln Gly Gly 
145                 150                 155                 160 


Lys Thr Leu Ser Val Ser Gln Leu Glu Leu Gln Asp Ser Gly Thr Trp 
                165                 170                 175     


Thr Cys Thr Val Leu Gln Asn Gln Lys Lys Val Glu Phe Lys Ile Asp 
            180                 185                 190         


Ile Val Val Leu Ala Ala Ala Asp Pro Glu Pro Lys Ser Cys Asp Lys 
        195                 200                 205             


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
    210                 215                 220                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Pro Lys Asp Thr Leu Met Ile 
225                 230                 235                 240 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                245                 250                 255     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            260                 265                 270         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        275                 280                 285             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    290                 295                 300                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
305                 310                 315                 320 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                325                 330                 335     


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
            340                 345                 350         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        355                 360                 365             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    370                 375                 380                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
385                 390                 395                 400 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                405                 410                 415     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            420                 425                 430         


Gly Lys Gly Gly Gly Gly Gly Asp Tyr Ala Asp Tyr Asp Gly Gly Tyr 
        435                 440                 445             


Tyr Tyr Asp Met Asp 
    450             


<210>  4
<211>  1383
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human eCD4-Ig

<400>  4
ggatccgcca ccatggactg gacttggagg attctgtttc tggtcgccgc cgctactgga       60

acccacgcta aaaaggtcgt gctgggcaaa aagggagaca cagtggagct gacctgcaca      120

gcctcccaga agaagtctat ccagttccac tggaagaact ccaatcagat caagatcctg      180

ggcaacgccg gctcctttct gaccaagggc ccatctaagc tgaatgacag agccgatagc      240

aggagatccc tgtgggacca gggcaacttc cccctgatca tcaagaatct gaagatcgag      300

gactctgata cctacatctg cgaggtggag gaccagaagg aggaggtgca gctgctggtg      360

tttggcctga cagccaacag cgatacccac ctgctgcagg gacagagcct gaccctgaca      420

ctggagagcc ctcccggcag ctccccaagc gtgcagtgta ggagccccag gggcaagaac      480

atccagggcg gcaagaccct gtctgtgagc cagctggagc tgcaggacag cggcacctgg      540

acatgcaccg tgctgcagaa tcagaagaag gtggagttca agatcgatat cgtggtgctg      600

gcagcagccg accccgagcc taagagctgt gataagacac acacctgccc accctgtcca      660

gcaccagagc tgctgggcgg cccttccgtg ttcctgtttc ctccaaagcc ccctaaggac      720

acactgatga tctctaggac acccgaggtg acctgcgtgg tggtggacgt gagccacgag      780

gaccccgagg tgaagtttaa ctggtacgtg gatggcgtgg aggtgcacaa tgccaagacc      840

aagccaaggg aggagcagta caactctaca tatagagtgg tgagcgtgct gaccgtgctg      900

caccaggact ggctgaacgg caaggagtat aagtgcaagg tgtccaataa ggccctgcct      960

gccccaatcg agaagacaat ctctaaggca aagggacagc cccgggagcc tcaggtgtac     1020

accctgccac ccagccgcga cgagctgaca aagaaccagg tgtccctgac ctgtctggtg     1080

aagggcttct atccttccga tatcgccgtg gagtgggagt ctaatggcca gccagagaac     1140

aattacaaga ccacacctcc agtgctggac tctgatggca gcttctttct gtattctaag     1200

ctgacagtgg ataagagcag gtggcagcag ggcaacgtgt tttcctgttc tgtgatgcac     1260

gaggccctgc acaatcacta tacccagaag agcctgtccc tgtctcccgg caagggcggc     1320

gggggcggag actatgctga ctatgacgga ggctattact atgacatgga ctgataactc     1380

gag                                                                   1383


<210>  5
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE TPST2

<400>  5

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Arg Leu Ser Val Arg Arg Val Leu Leu Ala Ala Gly Cys Ala 
            20                  25                  30          


Leu Val Leu Val Leu Ala Val Gln Leu Gly Gln Gln Val Leu Glu Cys 
        35                  40                  45              


Arg Ala Val Leu Ala Gly Leu Arg Ser Pro Arg Gly Ala Met Arg Pro 
    50                  55                  60                  


Glu Gln Glu Glu Leu Val Met Val Gly Thr Asn His Val Glu Tyr Arg 
65                  70                  75                  80  


Tyr Gly Lys Ala Met Pro Leu Ile Phe Val Gly Gly Val Pro Arg Ser 
                85                  90                  95      


Gly Thr Thr Leu Met Arg Ala Met Leu Asp Ala His Pro Glu Val Arg 
            100                 105                 110         


Cys Gly Glu Glu Thr Arg Ile Ile Pro Arg Val Leu Ala Met Arg Gln 
        115                 120                 125             


Ala Trp Ser Lys Ser Gly Arg Glu Lys Leu Arg Leu Asp Glu Ala Gly 
    130                 135                 140                 


Val Thr Asp Glu Val Leu Asp Ala Ala Met Gln Ala Phe Ile Leu Glu 
145                 150                 155                 160 


Val Ile Ala Lys His Gly Glu Pro Ala Arg Val Leu Cys Asn Lys Asp 
                165                 170                 175     


Pro Phe Thr Leu Lys Ser Ser Val Tyr Leu Ser Arg Leu Phe Pro Asn 
            180                 185                 190         


Ser Lys Phe Leu Leu Met Val Arg Asp Gly Arg Ala Ser Val His Ser 
        195                 200                 205             


Met Ile Thr Arg Lys Val Thr Ile Ala Gly Phe Asp Leu Ser Ser Tyr 
    210                 215                 220                 


Arg Asp Cys Leu Thr Lys Trp Asn Lys Ala Ile Glu Val Met Tyr Ala 
225                 230                 235                 240 


Gln Cys Met Glu Val Gly Lys Glu Lys Cys Leu Pro Val Tyr Tyr Glu 
                245                 250                 255     


Gln Leu Val Leu His Pro Arg Arg Ser Leu Lys Leu Ile Leu Asp Phe 
            260                 265                 270         


Leu Gly Ile Ala Trp Ser Asp Ala Val Leu His His Glu Asp Leu Ile 
        275                 280                 285             


Gly Lys Pro Gly Gly Val Ser Leu Ser Lys Ile Glu Arg Ser Thr Asp 
    290                 295                 300                 


Gln Val Ile Lys Pro Val Asn Leu Glu Ala Leu Ser Lys Trp Thr Gly 
305                 310                 315                 320 


His Ile Pro Gly Asp Val Val Arg Asp Met Ala Gln Ile Ala Pro Met 
                325                 330                 335     


Leu Ala Gln Leu Gly Tyr Asp Pro Tyr Ala Asn Pro Pro Asn Tyr Gly 
            340                 345                 350         


Asn Pro Asp Pro Phe Val Ile Asn Asn Thr Gln Arg Val Leu Lys Gly 
        355                 360                 365             


Asp Tyr Lys Thr Pro Ala Asn Leu Lys Gly Tyr Phe Gln Val Asn Gln 
    370                 375                 380                 


Asn Ser Thr Ser Ser His Leu Gly Ser Ser 
385                 390                 


<210>  6
<211>  1206
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgE TPST2

<400>  6
ggatccgcca ccatggattg gacctggatt ctgtttctgg tcgctgccgc tacaagggtg       60

cattcaagac tgtccgtgcg ccgggtgctg ctggccgctg gatgcgcact ggtgctggtg      120

ctggcagtgc agctgggaca gcaggtgctg gagtgtaggg ccgtgctggc aggcctgcgg      180

tcccctcgcg gcgccatgcg cccagagcag gaggagctgg tcatggtggg caccaatcac      240

gtggagtacc ggtatggcaa ggccatgcca ctgatcttcg tgggcggcgt gcctcggtct      300

ggaaccacac tgatgagggc aatgctggac gcacacccag aggtgaggtg cggagaggag      360

acaaggatca tcccccgcgt gctggcaatg agacaggcat ggtccaagtc tggcagggag      420

aagctgagac tggatgaggc cggcgtgaca gacgaggtgc tggatgccgc catgcaggcc      480

ttcatcctgg aagtgatcgc aaagcacgga gagccagccc gggtgctgtg caataaggac      540

ccctttaccc tgaagagctc cgtgtacctg tcccgcctgt tccccaactc taagtttctg      600

ctgatggtga gggatggcag agcctctgtg cacagcatga tcaccaggaa ggtgacaatc      660

gccggcttcg acctgtctag ctacagagat tgtctgacaa agtggaataa ggccatcgaa      720

gtgatgtatg cccagtgcat ggaagtgggc aaggagaagt gtctgcccgt gtactatgag      780

cagctggtgc tgcaccctag gagaagcctg aagctgatcc tggactttct gggaatcgca      840

tggtccgacg ccgtgctgca ccacgaggat ctgatcggca agcccggcgg cgtgagcctg      900

tccaagatcg agaggtctac cgatcaggtc atcaagcctg tgaacctgga ggccctgagc      960

aagtggacag gccacatccc aggcgacgtg gtgagagata tggcccagat cgcccctatg     1020

ctggcccagc tgggctacga cccatatgcc aaccctccca attacggcaa cccagatccc     1080

tttgtgatca acaataccca gcgcgtgctg aagggcgact ataagacacc tgccaatctg     1140

aagggctatt tccaggtcaa ccagaactca acatcctctc atctggggag cagttgataa     1200

ctcgag                                                                1206


<210>  7
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPST2

<400>  7

Met Arg Leu Ser Val Arg Arg Val Leu Leu Ala Ala Gly Cys Ala Leu 
1               5                   10                  15      


Val Leu Val Leu Ala Val Gln Leu Gly Gln Gln Val Leu Glu Cys Arg 
            20                  25                  30          


Ala Val Leu Ala Gly Leu Arg Ser Pro Arg Gly Ala Met Arg Pro Glu 
        35                  40                  45              


Gln Glu Glu Leu Val Met Val Gly Thr Asn His Val Glu Tyr Arg Tyr 
    50                  55                  60                  


Gly Lys Ala Met Pro Leu Ile Phe Val Gly Gly Val Pro Arg Ser Gly 
65                  70                  75                  80  


Thr Thr Leu Met Arg Ala Met Leu Asp Ala His Pro Glu Val Arg Cys 
                85                  90                  95      


Gly Glu Glu Thr Arg Ile Ile Pro Arg Val Leu Ala Met Arg Gln Ala 
            100                 105                 110         


Trp Ser Lys Ser Gly Arg Glu Lys Leu Arg Leu Asp Glu Ala Gly Val 
        115                 120                 125             


Thr Asp Glu Val Leu Asp Ala Ala Met Gln Ala Phe Ile Leu Glu Val 
    130                 135                 140                 


Ile Ala Lys His Gly Glu Pro Ala Arg Val Leu Cys Asn Lys Asp Pro 
145                 150                 155                 160 


Phe Thr Leu Lys Ser Ser Val Tyr Leu Ser Arg Leu Phe Pro Asn Ser 
                165                 170                 175     


Lys Phe Leu Leu Met Val Arg Asp Gly Arg Ala Ser Val His Ser Met 
            180                 185                 190         


Ile Thr Arg Lys Val Thr Ile Ala Gly Phe Asp Leu Ser Ser Tyr Arg 
        195                 200                 205             


Asp Cys Leu Thr Lys Trp Asn Lys Ala Ile Glu Val Met Tyr Ala Gln 
    210                 215                 220                 


Cys Met Glu Val Gly Lys Glu Lys Cys Leu Pro Val Tyr Tyr Glu Gln 
225                 230                 235                 240 


Leu Val Leu His Pro Arg Arg Ser Leu Lys Leu Ile Leu Asp Phe Leu 
                245                 250                 255     


Gly Ile Ala Trp Ser Asp Ala Val Leu His His Glu Asp Leu Ile Gly 
            260                 265                 270         


Lys Pro Gly Gly Val Ser Leu Ser Lys Ile Glu Arg Ser Thr Asp Gln 
        275                 280                 285             


Val Ile Lys Pro Val Asn Leu Glu Ala Leu Ser Lys Trp Thr Gly His 
    290                 295                 300                 


Ile Pro Gly Asp Val Val Arg Asp Met Ala Gln Ile Ala Pro Met Leu 
305                 310                 315                 320 


Ala Gln Leu Gly Tyr Asp Pro Tyr Ala Asn Pro Pro Asn Tyr Gly Asn 
                325                 330                 335     


Pro Asp Pro Phe Val Ile Asn Asn Thr Gln Arg Val Leu Lys Gly Asp 
            340                 345                 350         


Tyr Lys Thr Pro Ala Asn Leu Lys Gly Tyr Phe Gln Val Asn Gln Asn 
        355                 360                 365             


Ser Thr Ser Ser His Leu Gly Ser Ser 
    370                 375         


<210>  8
<211>  1155
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPST2

<400>  8
ggatccgcca ccatgagact gtccgtgcgc cgggtgctgc tggccgctgg atgcgcactg       60

gtgctggtgc tggcagtgca gctgggacag caggtgctgg agtgtagggc cgtgctggca      120

ggcctgcggt cccctcgcgg cgccatgcgc ccagagcagg aggagctggt catggtgggc      180

accaatcacg tggagtaccg gtatggcaag gccatgccac tgatcttcgt gggcggcgtg      240

cctcggtctg gaaccacact gatgagggca atgctggacg cacacccaga ggtgaggtgc      300

ggagaggaga caaggatcat cccccgcgtg ctggcaatga gacaggcatg gtccaagtct      360

ggcagggaga agctgagact ggatgaggcc ggcgtgacag acgaggtgct ggatgccgcc      420

atgcaggcct tcatcctgga agtgatcgca aagcacggag agccagcccg ggtgctgtgc      480

aataaggacc cctttaccct gaagagctcc gtgtacctgt cccgcctgtt ccccaactct      540

aagtttctgc tgatggtgag ggatggcaga gcctctgtgc acagcatgat caccaggaag      600

gtgacaatcg ccggcttcga cctgtctagc tacagagatt gtctgacaaa gtggaataag      660

gccatcgaag tgatgtatgc ccagtgcatg gaagtgggca aggagaagtg tctgcccgtg      720

tactatgagc agctggtgct gcaccctagg agaagcctga agctgatcct ggactttctg      780

ggaatcgcat ggtccgacgc cgtgctgcac cacgaggatc tgatcggcaa gcccggcggc      840

gtgagcctgt ccaagatcga gaggtctacc gatcaggtca tcaagcctgt gaacctggag      900

gccctgagca agtggacagg ccacatccca ggcgacgtgg tgagagatat ggcccagatc      960

gcccctatgc tggcccagct gggctacgac ccatatgcca accctcccaa ttacggcaac     1020

ccagatccct ttgtgatcaa caatacccag cgcgtgctga agggcgacta taagacacct     1080

gccaatctga agggctattt ccaggtcaac cagaactcaa catcctctca tctggggagc     1140

agttgataac tcgag                                                      1155


<210>  9
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPST2 delta TM

<400>  9

Met Arg Leu Ser Val Arg Arg Val Gln Gln Val Leu Glu Cys Arg Ala 
1               5                   10                  15      


Val Leu Ala Gly Leu Arg Ser Pro Arg Gly Ala Met Arg Pro Glu Gln 
            20                  25                  30          


Glu Glu Leu Val Met Val Gly Thr Asn His Val Glu Tyr Arg Tyr Gly 
        35                  40                  45              


Lys Ala Met Pro Leu Ile Phe Val Gly Gly Val Pro Arg Ser Gly Thr 
    50                  55                  60                  


Thr Leu Met Arg Ala Met Leu Asp Ala His Pro Glu Val Arg Cys Gly 
65                  70                  75                  80  


Glu Glu Thr Arg Ile Ile Pro Arg Val Leu Ala Met Arg Gln Ala Trp 
                85                  90                  95      


Ser Lys Ser Gly Arg Glu Lys Leu Arg Leu Asp Glu Ala Gly Val Thr 
            100                 105                 110         


Asp Glu Val Leu Asp Ala Ala Met Gln Ala Phe Ile Leu Glu Val Ile 
        115                 120                 125             


Ala Lys His Gly Glu Pro Ala Arg Val Leu Cys Asn Lys Asp Pro Phe 
    130                 135                 140                 


Thr Leu Lys Ser Ser Val Tyr Leu Ser Arg Leu Phe Pro Asn Ser Lys 
145                 150                 155                 160 


Phe Leu Leu Met Val Arg Asp Gly Arg Ala Ser Val His Ser Met Ile 
                165                 170                 175     


Thr Arg Lys Val Thr Ile Ala Gly Phe Asp Leu Ser Ser Tyr Arg Asp 
            180                 185                 190         


Cys Leu Thr Lys Trp Asn Lys Ala Ile Glu Val Met Tyr Ala Gln Cys 
        195                 200                 205             


Met Glu Val Gly Lys Glu Lys Cys Leu Pro Val Tyr Tyr Glu Gln Leu 
    210                 215                 220                 


Val Leu His Pro Arg Arg Ser Leu Lys Leu Ile Leu Asp Phe Leu Gly 
225                 230                 235                 240 


Ile Ala Trp Ser Asp Ala Val Leu His His Glu Asp Leu Ile Gly Lys 
                245                 250                 255     


Pro Gly Gly Val Ser Leu Ser Lys Ile Glu Arg Ser Thr Asp Gln Val 
            260                 265                 270         


Ile Lys Pro Val Asn Leu Glu Ala Leu Ser Lys Trp Thr Gly His Ile 
        275                 280                 285             


Pro Gly Asp Val Val Arg Asp Met Ala Gln Ile Ala Pro Met Leu Ala 
    290                 295                 300                 


Gln Leu Gly Tyr Asp Pro Tyr Ala Asn Pro Pro Asn Tyr Gly Asn Pro 
305                 310                 315                 320 


Asp Pro Phe Val Ile Asn Asn Thr Gln Arg Val Leu Lys Gly Asp Tyr 
                325                 330                 335     


Lys Thr Pro Ala Asn Leu Lys Gly Tyr Phe Gln Val Asn Gln Asn Ser 
            340                 345                 350         


Thr Ser Ser His Leu Gly Ser Ser 
        355                 360 


<210>  10
<211>  1104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPST2 delta TM

<400>  10
ggatccgcca ccatgagact gtccgtgcgc cgggtgcagc aggtgctgga gtgtagggcc       60

gtgctggcag gcctgcggtc ccctcgcggc gccatgcgcc cagagcagga ggagctggtc      120

atggtgggca ccaatcacgt ggagtaccgg tatggcaagg ccatgccact gatcttcgtg      180

ggcggcgtgc ctcggtctgg aaccacactg atgagggcaa tgctggacgc acacccagag      240

gtgaggtgcg gagaggagac aaggatcatc ccccgcgtgc tggcaatgag acaggcatgg      300

tccaagtctg gcagggagaa gctgagactg gatgaggccg gcgtgacaga cgaggtgctg      360

gatgccgcca tgcaggcctt catcctggaa gtgatcgcaa agcacggaga gccagcccgg      420

gtgctgtgca ataaggaccc ctttaccctg aagagctccg tgtacctgtc ccgcctgttc      480

cccaactcta agtttctgct gatggtgagg gatggcagag cctctgtgca cagcatgatc      540

accaggaagg tgacaatcgc cggcttcgac ctgtctagct acagagattg tctgacaaag      600

tggaataagg ccatcgaagt gatgtatgcc cagtgcatgg aagtgggcaa ggagaagtgt      660

ctgcccgtgt actatgagca gctggtgctg caccctagga gaagcctgaa gctgatcctg      720

gactttctgg gaatcgcatg gtccgacgcc gtgctgcacc acgaggatct gatcggcaag      780

cccggcggcg tgagcctgtc caagatcgag aggtctaccg atcaggtcat caagcctgtg      840

aacctggagg ccctgagcaa gtggacaggc cacatcccag gcgacgtggt gagagatatg      900

gcccagatcg cccctatgct ggcccagctg ggctacgacc catatgccaa ccctcccaat      960

tacggcaacc cagatccctt tgtgatcaac aatacccagc gcgtgctgaa gggcgactat     1020

aagacacctg ccaatctgaa gggctatttc caggtcaacc agaactcaac atcctctcat     1080

ctggggagca gttgataact cgag                                            1104


<210>  11
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE signal peptide

<400>  11

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser 
        


<210>  12
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dileucine motif


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  any amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  any amino acid

<400>  12

Asp Xaa Xaa Leu Leu 
1               5   


<210>  13
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tyrosine-based motif


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  any amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  any amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  an amino acid with a bulky hydrophobic side chain

<400>  13

Tyr Xaa Xaa Xaa 
1               


