                         SEQUENCE LISTING

<110>  The Regents of the University of California
 
<120>  STEM CELL-ENGINEERED INKT CELL-BASED OFF-THE-SHELF CELLULAR THERAPY

<130>  UCLA.P0063WO

<140>  Unknown
<141>  2019-06-12

<150>  US 62/683,750
<151>  2018-06-12

<160>  74    

<170>  PatentIn version 3.5

<210>  1
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  iNKT TCR-alpha chain cloned sequence

<400>  1
gtgggcgata gaggttcagc cttagggagg ctgcattttg gagctgggac tcagctgatt       60

gtcatacctg acatc                                                        75


<210>  2
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  iNKT TCR-beta chain cloned sequence

<400>  2
gccagcggtg atgctcgggg ggggggaaat accctctatt ttggaaaagg aagccggctc       60

attgttgtag aggat                                                        75


<210>  3
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  iNKT TCR-beta chain cloned sequence

<400>  3
gccagcgggg ggacagtcca ttctggaaat acgctctatt ttggagaagg aagccggctc       60

attgttgtag aggat                                                        75


<210>  4
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  iNKT TCR-beta chain cloned sequence

<400>  4
gccagcggtg atacgggaca aacaaacaca gaagtcttct ttggtaaagg aaccagactc       60

acagttgtag aggat                                                        75


<210>  5
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  iNKT TCR-beta chain cloned sequence

<400>  5
gccagcggtg aggggacagc aaacacagaa gtcttctttg gtaaaggaac cagactcaca       60

gttgtagagg at                                                           72


<210>  6
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  iNKT TCR-beta chain cloned sequence

<400>  6
gccagcggtg aggcagggaa cacagaagtc ttctttggta aaggaaccag actcacagtt       60

gtagaggat                                                               69


<210>  7
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  iNKT TCR-alpha chain cloned sequence

<400>  7
gtgagcgaca gaggctcaac cctggggagg ctatactttg gaagaggaac tcagttgact       60

gtctggcctg atatccag                                                     78


<210>  8
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  iNKT TCR-beta chain cloned sequence

<400>  8
agcagtgacc tccgaggaca gaacacagat acgcagtatt ttggcccagg cacccggctg       60

acagtgctcg aggac                                                        75


<210>  9
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  iNKT TCR-beta chain cloned sequence

<400>  9
agcagtgaat taaaggaaac aggggttcaa gagacccagt acttcgggcc aggcacgcgg       60

ctcctggtgc tcgaggac                                                     78


<210>  10
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  iNKT TCR-beta chain cloned sequence

<400>  10
agcagtgtat ctcagggcgg cactgaagct ttctttggac aaggcaccag actcacagtt       60

gtagaggac                                                               69


<210>  11
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  iNKT TCR-beta chain cloned sequence

<400>  11
agcagtgtat ctcagggcgg cactgaagct ttctttggac aaggcaccag actcacagtt       60

gtagaggac                                                               69


<210>  12
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  iNKT TCR-beta chain cloned sequence

<400>  12
agcagtgacc ggacaggcgt gaacactgaa gctttctttg gacaaggcac cagactcaca       60

gttgtagagg ac                                                           72


<210>  13
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  iNKT TCR-beta chain cloned sequence

<400>  13
agcagtgaac cggacagggg gggggctgaa gctttctttg gacaaggcac cagactcaca       60

gttgtagagg ac                                                           72


<210>  14
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  iNKT TCR-apha chain forward primer

<400>  14
gggagatact cagcaactct ggataaagat gc                                     32


<210>  15
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  iNKT TCR-apha chain reverse primer

<400>  15
ccagattcca tggttttcgg cacattg                                           27


<210>  16
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  iNKT TCR-beta chain forward primer

<400>  16
ggagatatcc ctgatggata caaggcctcc                                        30


<210>  17
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  iNKT TCR-beta chain reverse primer

<400>  17
gggtagcctt ttgtttgttt gcaatctctg                                        30


<210>  18
<211>  831
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR-alpha chain cDNA

<400>  18
atgaaaaagc atctgacgac cttcttggtg attttgtggc tttattttta tagggggaat       60

ggcaaaaacc aagtggagca gagtcctcag tccctgatca tcctggaggg aaagaactgc      120

actcttcaat gcaattatac agtgagcccc ttcagcaact taaggtggta taagcaagat      180

actgggagag gtcctgtttc cctgacaatc atgactttca gtgagaacac aaagtcgaac      240

ggaagatata cagcaactct ggatgcagac acaaagcaaa gctctctgca catcacagcc      300

tcccagctca gcgattcagc ctcctacatc tgtgtggtga gcgacagagg ctcaaccctg      360

gggaggctat actttggaag aggaactcag ttgactgtct ggcctgatat ccagaaccct      420

gaccctgccg tgtaccagct gagagactct aaatccagtg acaagtctgt ctgcctattc      480

accgattttg attctcaaac aaatgtgtca caaagtaagg attctgatgt gtatatcaca      540

gacaaaactg tgctagacat gaggtctatg gacttcaaga gcaacagtgc tgtggcctgg      600

agcaacaaat ctgactttgc atgtgcaaac gccttcaaca acagcattat tccagaagac      660

accttcttcc ccagcccaga aagttcctgt gatgtcaagc tggtcgagaa aagctttgaa      720

acagatacga acctaaactt tcaaaacctg tcagtgattg ggttccgaat cctcctcctg      780

aaagtggccg ggtttaatct gctcatgacg ctgcggctgt ggtccagctg a               831


<210>  19
<211>  831
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR-alpha chain cDNA codon-optimized

<400>  19
atgaaaaagc atctgacaac attcctggtc attctgtggc tgtacttcta ccgaggcaac       60

ggcaaaaatc aggtggagca gtccccacag tccctgatca ttctggaggg gaagaactgc      120

actctgcagt gtaattacac cgtgtctccc tttagtaacc tgcgctggta taaacaggac      180

accggacgag gacccgtgag cctgacaatc atgactttct cagagaacac aaagagcaat      240

ggacggtaca ccgctacact ggacgcagat accaaacaga gctccctgca catcacagca      300

tctcagctgt cagatagcgc ctcctacatt tgcgtggtct ctgaccgagg gagtaccctg      360

ggccgactgt attttggaag ggggacccag ctgacagtgt ggcccgacat ccagaaccca      420

gatcccgccg tctaccagct gcgcgacagc aagtctagtg ataaaagcgt gtgcctgttc      480

acagactttg attctcagac taatgtctct cagagtaagg acagtgacgt gtacattact      540

gacaaaaccg tcctggatat gaggagcatg gacttcaagt caaacagcgc cgtggcttgg      600

tcaaacaaga gcgacttcgc atgcgccaat gcttttaaca attcaatcat tccagaggat      660

accttctttc ctagcccaga atcaagctgt gacgtgaagc tggtcgagaa aagtttcgaa      720

actgatacca acctgaattt tcagaacctg tctgtgatcg gcttcagaat cctgctgctg      780

aaggtcgccg gctttaatct gctgatgaca ctgagactgt ggtcctcttg a               831


<210>  20
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR-alpha chain

<400>  20

Met Lys Lys His Leu Thr Thr Phe Leu Val Ile Leu Trp Leu Tyr Phe 
1               5                   10                  15      


Tyr Arg Gly Asn Gly Lys Asn Gln Val Glu Gln Ser Pro Gln Ser Leu 
            20                  25                  30          


Ile Ile Leu Glu Gly Lys Asn Cys Thr Leu Gln Cys Asn Tyr Thr Val 
        35                  40                  45              


Ser Pro Phe Ser Asn Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly 
    50                  55                  60                  


Pro Val Ser Leu Thr Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn 
65                  70                  75                  80  


Gly Arg Tyr Thr Ala Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu 
                85                  90                  95      


His Ile Thr Ala Ser Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val 
            100                 105                 110         


Val Ser Asp Arg Gly Ser Thr Leu Gly Arg Leu Tyr Phe Gly Arg Gly 
        115                 120                 125             


Thr Gln Leu Thr Val Trp Pro Asp Ile Gln Asn Pro Asp Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe 
145                 150                 155                 160 


Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp 
                165                 170                 175     


Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe 
            180                 185                 190         


Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys 
        195                 200                 205             


Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro 
    210                 215                 220                 


Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu 
225                 230                 235                 240 


Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg 
                245                 250                 255     


Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg 
            260                 265                 270         


Leu Trp Ser Ser 
        275     


<210>  21
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR-beta chain cDNA (before D/J/N region)

<400>  21
atgactatca ggctcctctg ctacatgggc ttttattttc tgggggcagg cctcatggaa       60

gctgacatct accagacccc aagatacctt gttataggga caggaaagaa gatcactctg      120

gaatgttctc aaaccatggg ccatgacaaa atgtactggt atcaacaaga tccaggaatg      180

gaactacacc tcatccacta ttcctatgga gttaattcca cagagaaggg agatctttcc      240

tctgagtcaa cagtctccag aataaggacg gagcattttc ccctgaccct ggagtctgcc      300

aggccctcac atacctctca gtacctctgt gccagc                                336


<210>  22
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR-beta chain cDNA codon-optimized

<400>  22
atgaccatcc ggctgctgtg ctacatgggc ttctattttc tgggggcagg cctgatggaa       60

gccgacatct accagactcc cagatacctg gtcatcggaa ccgggaagaa aattacactg      120

gagtgttccc agacaatggg ccacgataag atgtactggt atcagcagga ccctgggatg      180

gaactgcacc tgatccatta ctcctatggc gtgaactcta ccgagaaggg cgacctgagc      240

agcgaatcca ccgtctctcg aattaggaca gagcactttc ctctgactct ggaaagcgcc      300

cgaccaagtc atacatcaca gtacctgtgc gctagc                                336


<210>  23
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR-beta chain

<400>  23

Met Thr Ile Arg Leu Leu Cys Tyr Met Gly Phe Tyr Phe Leu Gly Ala 
1               5                   10                  15      


Gly Leu Met Glu Ala Asp Ile Tyr Gln Thr Pro Arg Tyr Leu Val Ile 
            20                  25                  30          


Gly Thr Gly Lys Lys Ile Thr Leu Glu Cys Ser Gln Thr Met Gly His 
        35                  40                  45              


Asp Lys Met Tyr Trp Tyr Gln Gln Asp Pro Gly Met Glu Leu His Leu 
    50                  55                  60                  


Ile His Tyr Ser Tyr Gly Val Asn Ser Thr Glu Lys Gly Asp Leu Ser 
65                  70                  75                  80  


Ser Glu Ser Thr Val Ser Arg Ile Arg Thr Glu His Phe Pro Leu Thr 
                85                  90                  95      


Leu Glu Ser Ala Arg Pro Ser His Thr Ser Gln Tyr Leu Cys Ala Ser 
            100                 105                 110         


<210>  24
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  24
gtagcggttg ggccccaaga gacccagtac ttcgggccag gcacgcggct cctggtgctc       60


<210>  25
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  25
gtggcagtcg gacctcagga gacccagtac ttcggacccg gcacccgcct gctggtgctg       60


<210>  26
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  26

Val Ala Val Gly Pro Gln Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
1               5                   10                  15      


Leu Leu Val Leu 
            20  


<210>  27
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  27
agtgggccag ggtacgagca gtacttcggg ccgggcacca ggctcacggt caca             54


<210>  28
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  28
tcaggacccg gctacgagca gtatttcggc cccggaactc ggctgaccgt gacc             54


<210>  29
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  29

Ser Gly Pro Gly Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr 
1               5                   10                  15      


Val Thr 
        


<210>  30
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  30
agtccccaat taaacactga agctttcttt ggacaaggca ccagactcac agttgta          57


<210>  31
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  31
tctccacagc tgaacaccga ggccttcttc gggcagggca caaggcttac cgtggtg          57


<210>  32
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  32

Ser Pro Gln Leu Asn Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu 
1               5                   10                  15      


Thr Val Val 
            


<210>  33
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  33
agtgaattgc gggcgctcgg gcccagctcc tataattcac ccctccactt tgggaacggg       60

accaggctca ctgtgaca                                                     78


<210>  34
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  34
tccgaactcc gagccctggg gcctagctcc tacaatagcc ccctgcactt tggcaacgga       60

accaggctga cggtcacc                                                     78


<210>  35
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  35

Ser Glu Leu Arg Ala Leu Gly Pro Ser Ser Tyr Asn Ser Pro Leu His 
1               5                   10                  15      


Phe Gly Asn Gly Thr Arg Leu Thr Val Thr 
            20                  25      


<210>  36
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  36
agtgaacagg ggactactgc gggagctttc tttggacaag gcaccagact cacagttgta       60


<210>  37
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  37
tccgaacagg gaaccacagc aggagccttc ttcggtcagg gaacaagact gacagtcgtg       60


<210>  38
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  38

Ser Glu Gln Gly Thr Thr Ala Gly Ala Phe Phe Gly Gln Gly Thr Arg 
1               5                   10                  15      


Leu Thr Val Val 
            20  


<210>  39
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  39
agtgagtcac gacatgcgac aggaaacacc atatattttg gagagggaag ttggctcact       60

gttgta                                                                  66


<210>  40
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  40
agcgagagca ggcacgcaac cgggaacacc atatactttg gcgagggctc ctggctgact       60

gtggtg                                                                  66


<210>  41
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  41

Ser Glu Ser Arg His Ala Thr Gly Asn Thr Ile Tyr Phe Gly Glu Gly 
1               5                   10                  15      


Ser Trp Leu Thr Val Val 
            20          


<210>  42
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  42
agtgtacccg ggaacgacag gggcaatgaa aaactgtttt ttggcagtgg aacccagctc       60

tctgtcttg                                                               69


<210>  43
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  43
tccgtgcctg gcaacgatag aggtaacgag aagctgtttt tcggatccgg cacacagctg       60

tctgtcctg                                                               69


<210>  44
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  44

Ser Val Pro Gly Asn Asp Arg Gly Asn Glu Lys Leu Phe Phe Gly Ser 
1               5                   10                  15      


Gly Thr Gln Leu Ser Val Leu 
            20              


<210>  45
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  45
agtgaagggg ggggccttaa gctagccaaa aacattcagt acttcggcgc cgggacccgg       60

ctctcagtgc tg                                                           72


<210>  46
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  46
agtgagggag ggggactgaa gctggctaag aatattcagt acttcggcgc cggcactaga       60

ctgtctgtgc tg                                                           72


<210>  47
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  47

Ser Glu Gly Gly Gly Leu Lys Leu Ala Lys Asn Ile Gln Tyr Phe Gly 
1               5                   10                  15      


Ala Gly Thr Arg Leu Ser Val Leu 
            20                  


<210>  48
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  48
agtgaattcg cctcttcggt acgtggaaac accatatatt ttggagaggg aagttggctc       60

actgttgta                                                               69


<210>  49
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  49
tctgagttcg cgagcagcgt ccggggtaat accatttact tcggggaagg cagctggctg       60

accgtggtg                                                               69


<210>  50
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  50

Ser Glu Phe Ala Ser Ser Val Arg Gly Asn Thr Ile Tyr Phe Gly Glu 
1               5                   10                  15      


Gly Ser Trp Leu Thr Val Val 
            20              


<210>  51
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  51
agtgcggcat taggccggga gacccagtac ttcgggccag gcacgcggct cctggtgctc       60


<210>  52
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  52
tctgcagccc ttggccgaga gactcagtac ttcggccctg gcacaagact gctcgtgctc       60


<210>  53
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  53

Ser Ala Ala Leu Gly Arg Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
1               5                   10                  15      


Leu Leu Val Leu 
            20  


<210>  54
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  54
agtgcctccg ggggtgaatc ctacgagcag tacttcgggc cgggcaccag gctcacggtc       60

aca                                                                     63


<210>  55
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  55
agcgcctccg gaggagagtc atacgaacag tatttcggcc ctggcacacg cctcactgtg       60

acc                                                                     63


<210>  56
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  56

Ser Ala Ser Gly Gly Glu Ser Tyr Glu Gln Tyr Phe Gly Pro Gly Thr 
1               5                   10                  15      


Arg Leu Thr Val Thr 
            20      


<210>  57
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  57
agcggtcggg tctcgggggg cgattccctc atagcgtttc taggccaaga gacccagtac       60

ttcgggccag gcacgcggct cctggtgctc                                        90


<210>  58
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  58
tcaggacgag tgtccggagg ggatagcctc atcgcatttc tggggcagga aactcagtac       60

ttcggacccg gaacacgcct cctggtgctg                                        90


<210>  59
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  59

Ser Gly Arg Val Ser Gly Gly Asp Ser Leu Ile Ala Phe Leu Gly Gln 
1               5                   10                  15      


Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Leu Val Leu 
            20                  25                  30  


<210>  60
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  60
agtgtacccg ggaacgacag gggcaatgaa aaactgtttt ttggcagtgg aacccagctc       60

tctgtcttg                                                               69


<210>  61
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  61
tccgtgcctg gcaacgatag aggtaacgag aagctgtttt tcggatccgg cacacagctg       60

tctgtcctg                                                               69


<210>  62
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR Beta Chain Diverse Region (D/J/N)

<400>  62

Ser Val Pro Gly Asn Asp Arg Gly Asn Glu Lys Leu Phe Phe Gly Ser 
1               5                   10                  15      


Gly Thr Gln Leu Ser Val Leu 
            20              


<210>  63
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR-beta chain cDNA (after D/J/N region)

<400>  63
gaggacctga acaaggtgtt cccacccgag gtcgctgtgt ttgagccatc agaagcagag       60

atctcccaca cccaaaaggc cacactggtg tgcctggcca caggcttctt ccctgaccac      120

gtggagctga gctggtgggt gaatgggaag gaggtgcaca gtggggtcag cacggacccg      180

cagcccctca aggagcagcc cgccctcaat gactccagat actgcctgag cagccgcctg      240

agggtctcgg ccaccttctg gcagaacccc cgcaaccact tccgctgcca agtccagttc      300

tacgggctct cggagaatga cgagtggacc caggataggg ccaaacccgt cacccagatc      360

gtcagcgccg aggcctgggg tagagcagac tgtggcttta cctcggtgtc ctaccagcaa      420

ggggtcctgt ctgccaccat cctctatgag atcctgctag ggaaggccac cctgtatgct      480

gtgctggtca gcgcccttgt gttgatggcc atggtcaaga gaaaggattt ctga            534


<210>  64
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR-beta chain cDNA codon-optimized (after D/J/N 
       region)

<400>  64
gaggacctga ataaggtgtt cccccctgag gtggctgtct ttgaaccaag tgaggcagaa       60

atttcacata cacagaaagc caccctggtg tgcctggcta ccggcttctt tcccgatcac      120

gtggagctga gctggtgggt caacggcaag gaagtgcata gcggagtctc cacagaccca      180

cagcccctga aagagcagcc tgctctgaat gattccagat actgcctgtc tagtagactg      240

cgggtgtctg ccaccttctg gcagaaccca aggaatcatt tcagatgtca ggtgcagttt      300

tatggcctga gcgagaacga tgaatggact caggacaggg ctaagccagt gacccagatc      360

gtcagcgcag aggcctgggg aagagcagac tgcgggttta caagcgtgag ctatcagcag      420

ggcgtcctga gcgccacaat cctgtacgaa attctgctgg gaaaggccac tctgtatgct      480

gtgctggtct ccgctctggt gctgatggca atggtcaagc ggaaagattt ctga            534


<210>  65
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human iNKT TCR-beta chain (after D/J/N region)

<400>  65

Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
1               5                   10                  15      


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
    50                  55                  60                  


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
65                  70                  75                  80  


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
                85                  90                  95      


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
            100                 105                 110         


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
        115                 120                 125             


Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser 
    130                 135                 140                 


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
145                 150                 155                 160 


Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp 
                165                 170                 175     


Phe 
    


<210>  66
<211>  2845
<212>  DNA
<213>  Homo sapiens

<400>  66
aagtggaggc gtcgcgctgg cgggcattcc tgaagctgac agcattcggg ccgagatgtc       60

tcgctccgtg gccttagctg tgctcgcgct actctctctt tctggcctgg aggctatcca      120

gcgtactcca aagattcagg tttactcacg tcatccagca gagaatggaa agtcaaattt      180

cctgaattgc tatgtgtctg ggtttcatcc atccgacatt gaagttgact tactgaagaa      240

tggagagaga attgaaaaag tggagcattc agacttgtct ttcagcaagg actggtcttt      300

ctatctcttg tactacactg aattcacccc cactgaaaaa gatgagtatg cctgccgtgt      360

gaaccatgtg actttgtcac agcccaagat agttaagtgg ggtaagtctt acattctttt      420

gtaagctgct gaaagttgtg tatgagtagt catatcataa agctgctttg atataaaaaa      480

ggtctatggc catactaccc tgaatgagtc ccatcccatc tgatataaac aatctgcata      540

ttgggattgt cagggaatgt tcttaaagat cagattagtg gcacctgctg agatactgat      600

gcacagcatg gtttctgaac cagtagtttc cctgcagttg agcagggagc agcagcagca      660

cttgcacaaa tacatataca ctcttaacac ttcttaccta ctggcttcct ctagcttttg      720

tggcagcttc aggtatattt agcactgaac gaacatctca agaaggtata ggcctttgtt      780

tgtaagtcct gctgtcctag catcctataa tcctggactt ctccagtact ttctggctgg      840

attggtatct gaggctagta ggaagggctt gttcctgctg ggtagctcta aacaatgtat      900

tcatgggtag gaacagcagc ctattctgcc agccttattt ctaaccattt tagacatttg      960

ttagtacatg gtattttaaa agtaaaactt aatgtcttcc ttttttttct ccactgtctt     1020

tttcatagat cgagacatgt aagcagcatc atggaggtaa gtttttgacc ttgagaaaat     1080

gtttttgttt cactgtcctg aggactattt atagacagct ctaacatgat aaccctcact     1140

atgtggagaa cattgacaga gtaacatttt agcagggaaa gaagaatcct acagggtcat     1200

gttcccttct cctgtggagt ggcatgaaga aggtgtatgg ccccaggtat ggccatatta     1260

ctgaccctct acagagaggg caaaggaact gccagtatgg tattgcagga taaaggcagg     1320

tggttaccca cattacctgc aaggctttga tctttcttct gccatttcca cattggacat     1380

ctctgctgag gagagaaaat gaaccactct tttcctttgt ataatgttgt tttattcttc     1440

agacagaaga gaggagttat acagctctgc agacatccca ttcctgtatg gggactgtgt     1500

ttgcctctta gaggttccca ggccactaga ggagataaag ggaaacagat tgttataact     1560

tgatataatg atactataat agatgtaact acaaggagct ccagaagcaa gagagaggga     1620

ggaacttgga cttctctgca tctttagttg gagtccaaag gcttttcaat gaaattctac     1680

tgcccagggt acattgatgc tgaaacccca ttcaaatctc ctgttatatt ctagaacagg     1740

gaattgattt gggagagcat caggaaggtg gatgatctgc ccagtcacac tgttagtaaa     1800

ttgtagagcc aggacctgaa ctctaatata gtcatgtgtt acttaatgac ggggacatgt     1860

tctgagaaat gcttacacaa acctaggtgt tgtagcctac tacacgcata ggctacatgg     1920

tatagcctat tgctcctaga ctacaaacct gtacagcctg ttactgtact gaatactgtg     1980

ggcagttgta acacaatggt aagtatttgt gtatctaaac atagaagttg cagtaaaaat     2040

atgctatttt aatcttatga gaccactgtc atatatacag tccatcattg accaaaacat     2100

catatcagca ttttttcttc taagattttg ggagcaccaa agggatacac taacaggata     2160

tactctttat aatgggtttg gagaactgtc tgcagctact tcttttaaaa aggtgatcta     2220

cacagtagaa attagacaag tttggtaatg agatctgcaa tccaaataaa ataaattcat     2280

tgctaacctt tttcttttct tttcaggttt gaagatgccg catttggatt ggatgaattc     2340

caaattctgc ttgcttgctt tttaatattg atatgcttat acacttacac tttatgcaca     2400

aaatgtaggg ttataataat gttaacatgg acatgatctt ctttataatt ctactttgag     2460

tgctgtctcc atgtttgatg tatctgagca ggttgctcca caggtagctc taggagggct     2520

ggcaacttag aggtggggag cagagaattc tcttatccaa catcaacatc ttggtcagat     2580

ttgaactctt caatctcttg cactcaaagc ttgttaagat agttaagcgt gcataagtta     2640

acttccaatt tacatactct gcttagaatt tgggggaaaa tttagaaata taattgacag     2700

gattattgga aatttgttat aatgaatgaa acattttgtc atataagatt catatttact     2760

tcttatacat ttgataaagt aaggcatggt tgtggttaat ctggtttatt tttgttccac     2820

aagttaaata aatcataaaa cttga                                           2845


<210>  67
<211>  4654
<212>  DNA
<213>  Homo sapiens

<400>  67
ggttagtgat gaggctagtg atgaggctgt gtgcttctga gctgggcatc cgaaggcatc       60

cttggggaag ctgagggcac gaggaggggc tgccagactc cgggagctgc tgcctggctg      120

ggattcctac acaatgcgtt gcctggctcc acgccctgct gggtcctacc tgtcagagcc      180

ccaaggcagc tcacagtgtg ccaccatgga gttggggccc ctagaaggtg gctacctgga      240

gcttcttaac agcgatgctg accccctgtg cctctaccac ttctatgacc agatggacct      300

ggctggagaa gaagagattg agctctactc agaacccgac acagacacca tcaactgcga      360

ccagttcagc aggctgttgt gtgacatgga aggtgatgaa gagaccaggg aggcttatgc      420

caatatcgcg gaactggacc agtatgtctt ccaggactcc cagctggagg gcctgagcaa      480

ggacattttc aagcacatag gaccagatga agtgatcggt gagagtatgg agatgccagc      540

agaagttggg cagaaaagtc agaaaagacc cttcccagag gagcttccgg cagacctgaa      600

gcactggaag ccagctgagc cccccactgt ggtgactggc agtctcctag tgggaccagt      660

gagcgactgc tccaccctgc cctgcctgcc actgcctgcg ctgttcaacc aggagccagc      720

ctccggccag atgcgcctgg agaaaaccga ccagattccc atgcctttct ccagttcctc      780

gttgagctgc ctgaatctcc ctgagggacc catccagttt gtccccacca tctccactct      840

gccccatggg ctctggcaaa tctctgaggc tggaacaggg gtctccagta tattcatcta      900

ccatggtgag gtgccccagg ccagccaagt accccctccc agtggattca ctgtccacgg      960

cctcccaaca tctccagacc ggccaggctc caccagcccc ttcgctccat cagccactga     1020

cctgcccagc atgcctgaac ctgccctgac ctcccgagca aacatgacag agcacaagac     1080

gtcccccacc caatgcccgg cagctggaga ggtctccaac aagcttccaa aatggcctga     1140

gccggtggag cagttctacc gctcactgca ggacacgtat ggtgccgagc ccgcaggccc     1200

ggatggcatc ctagtggagg tggatctggt gcaggccagg ctggagagga gcagcagcaa     1260

gagcctggag cgggaactgg ccaccccgga ctgggcagaa cggcagctgg cccaaggagg     1320

cctggctgag gtgctgttgg ctgccaagga gcaccggcgg ccgcgtgaga cacgagtgat     1380

tgctgtgctg ggcaaagctg gtcagggcaa gagctattgg gctggggcag tgagccgggc     1440

ctgggcttgt ggccggcttc cccagtacga ctttgtcttc tctgtcccct gccattgctt     1500

gaaccgtccg ggggatgcct atggcctgca ggatctgctc ttctccctgg gcccacagcc     1560

actcgtggcg gccgatgagg ttttcagcca catcttgaag agacctgacc gcgttctgct     1620

catcctagac ggcttcgagg agctggaagc gcaagatggc ttcctgcaca gcacgtgcgg     1680

accggcaccg gcggagccct gctccctccg ggggctgctg gccggccttt tccagaagaa     1740

gctgctccga ggttgcaccc tcctcctcac agcccggccc cggggccgcc tggtccagag     1800

cctgagcaag gccgacgccc tatttgagct gtccggcttc tccatggagc aggcccaggc     1860

atacgtgatg cgctactttg agagctcagg gatgacagag caccaagaca gagccctgac     1920

gctcctccgg gaccggccac ttcttctcag tcacagccac agccctactt tgtgccgggc     1980

agtgtgccag ctctcagagg ccctgctgga gcttggggag gacgccaagc tgccctccac     2040

gctcacggga ctctatgtcg gcctgctggg ccgtgcagcc ctcgacagcc cccccggggc     2100

cctggcagag ctggccaagc tggcctggga gctgggccgc agacatcaaa gtaccctaca     2160

ggaggaccag ttcccatccg cagacgtgag gacctgggcg atggccaaag gcttagtcca     2220

acacccaccg cgggccgcag agtccgagct ggccttcccc agcttcctcc tgcaatgctt     2280

cctgggggcc ctgtggctgg ctctgagtgg cgaaatcaag gacaaggagc tcccgcagta     2340

cctagcattg accccaagga agaagaggcc ctatgacaac tggctggagg gcgtgccacg     2400

ctttctggct gggctgatct tccagcctcc cgcccgctgc ctgggagccc tactcgggcc     2460

atcggcggct gcctcggtgg acaggaagca gaaggtgctt gcgaggtacc tgaagcggct     2520

gcagccgggg acactgcggg cgcggcagct gctggagctg ctgcactgcg cccacgaggc     2580

cgaggaggct ggaatttggc agcacgtggt acaggagctc cccggccgcc tctcttttct     2640

gggcacccgc ctcacgcctc ctgatgcaca tgtactgggc aaggccttgg aggcggcggg     2700

ccaagacttc tccctggacc tccgcagcac tggcatttgc ccctctggat tggggagcct     2760

cgtgggactc agctgtgtca cccgtttcag ggctgccttg agcgacacgg tggcgctgtg     2820

ggagtccctg cagcagcatg gggagaccaa gctacttcag gcagcagagg agaagttcac     2880

catcgagcct ttcaaagcca agtccctgaa ggatgtggaa gacctgggaa agcttgtgca     2940

gactcagagg acgagaagtt cctcggaaga cacagctggg gagctccctg ctgttcggga     3000

cctaaagaaa ctggagtttg cgctgggccc tgtctcaggc ccccaggctt tccccaaact     3060

ggtgcggatc ctcacggcct tttcctccct gcagcatctg gacctggatg cgctgagtga     3120

gaacaagatc ggggacgagg gtgtctcgca gctctcagcc accttccccc agctgaagtc     3180

cttggaaacc ctcaatctgt cccagaacaa catcactgac ctgggtgcct acaaactcgc     3240

cgaggccctg ccttcgctcg ctgcatccct gctcaggcta agcttgtaca ataactgcat     3300

ctgcgacgtg ggagccgaga gcttggctcg tgtgcttccg gacatggtgt ccctccgggt     3360

gatggacgtc cagtacaaca agttcacggc tgccggggcc cagcagctcg ctgccagcct     3420

tcggaggtgt cctcatgtgg agacgctggc gatgtggacg cccaccatcc cattcagtgt     3480

ccaggaacac ctgcaacaac aggattcacg gatcagcctg agatgatccc agctgtgctc     3540

tggacaggca tgttctctga ggacactaac cacgctggac cttgaactgg gtacttgtgg     3600

acacagctct tctccaggct gtatcccatg agcctcagca tcctggcacc cggcccctgc     3660

tggttcaggg ttggcccctg cccggctgcg gaatgaacca catcttgctc tgctgacaga     3720

cacaggcccg gctccaggct cctttagcgc ccagttgggt ggatgcctgg tggcagctgc     3780

ggtccaccca ggagccccga ggccttctct gaaggacatt gcggacagcc acggccaggc     3840

cagagggagt gacagaggca gccccattct gcctgcccag gcccctgcca ccctggggag     3900

aaagtacttc ttttttttta tttttagaca gagtctcact gttgcccagg ctggcgtgca     3960

gtggtgcgat ctgggttcac tgcaacctcc gcctcttggg ttcaagcgat tcttctgctt     4020

cagcctcccg agtagctggg actacaggca cccaccatca tgtctggcta atttttcatt     4080

tttagtagag acagggtttt gccatgttgg ccaggctggt ctcaaactct tgacctcagg     4140

tgatccaccc acctcagcct cccaaagtgc tgggattaca agcgtgagcc actgcaccgg     4200

gccacagaga aagtacttct ccaccctgct ctccgaccag acaccttgac agggcacacc     4260

gggcactcag aagacactga tgggcaaccc ccagcctgct aattccccag attgcaacag     4320

gctgggcttc agtggcagct gcttttgtct atgggactca atgcactgac attgttggcc     4380

aaagccaaag ctaggcctgg ccagatgcac cagcccttag cagggaaaca gctaatggga     4440

cactaatggg gcggtgagag gggaacagac tggaagcaca gcttcatttc ctgtgtcttt     4500

tttcactaca ttataaatgt ctctttaatg tcacaggcag gtccagggtt tgagttcata     4560

ccctgttacc attttggggt acccactgct ctggttatct aatatgtaac aagccacccc     4620

aaatcatagt ggcttaaaac aacactcaca ttta                                 4654


<210>  68
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  68
cgcgagcaca gcuaaggcca                                                   20


<210>  69
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  69
gauauuggca uaagccuccc                                                   20


<210>  70
<211>  996
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sr39TK cDNA sequence codon optimized

<400>  70
atgcctacac tgctgcgggt gtacatcgat ggccctcacg gcatgggcaa gaccacaacc       60

acacagctgc tggtggccct gggcagcagg gacgatatcg tgtacgtgcc agagcccatg      120

acatattggc gcgtgctggg agcatccgag acaatcgcca acatctacac cacacagcac      180

agactggatc agggagagat ctccgccggc gacgcagcag tggtcatgac cagcgcccag      240

atcacaatgg gcatgccata tgcagtgacc gacgccgtgc tggcacctca catcggagga      300

gaggcaggct ctagccacgc accaccccct gccctgacaa tctttctgga tcggcaccct      360

atcgccttca tgctgtgcta cccagccgcc agatatctga tgggcagcat gaccccacag      420

gccgtgctgg ccttcgtggc cctgatccca cccaccctgc caggaacaaa tatcgtgctg      480

ggcgccctgc cagaggacag gcacatcgat agactggcca agaggcagcg ccccggagag      540

cggctggacc tggcaatgct ggcagcaatc aggagagtgt acggcctgct ggccaacacc      600

gtgcggtatc tgcagtgtgg aggctcctgg agagaggact ggggacagct gtctggaaca      660

gcagtgcctc cacagggagc agagccacag tccaatgcag gacctaggcc acacatcggc      720

gataccctgt tcacactgtt tcgcgcacca gagctgctgg cacctaacgg cgatctgtac      780

aacgtgttcg catgggcact ggacgtgctg gcaaagcggc tgagatctat gcacgtgttc      840

atcctggact acgaccagag cccagccggc tgtagagatg ccctgctgca gctgacaagc      900

ggcatggtgc agacccacgt gaccacaccc ggctctattc caacaatctg cgacctggct      960

aggacctttg caagagaaat gggcgaagct aactga                                996


<210>  71
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sr39TK amino acid sequence

<400>  71

Met Pro Thr Leu Leu Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly 
1               5                   10                  15      


Lys Thr Thr Thr Thr Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp 
            20                  25                  30          


Ile Val Tyr Val Pro Glu Pro Met Thr Tyr Trp Arg Val Leu Gly Ala 
        35                  40                  45              


Ser Glu Thr Ile Ala Asn Ile Tyr Thr Thr Gln His Arg Leu Asp Gln 
    50                  55                  60                  


Gly Glu Ile Ser Ala Gly Asp Ala Ala Val Val Met Thr Ser Ala Gln 
65                  70                  75                  80  


Ile Thr Met Gly Met Pro Tyr Ala Val Thr Asp Ala Val Leu Ala Pro 
                85                  90                  95      


His Ile Gly Gly Glu Ala Gly Ser Ser His Ala Pro Pro Pro Ala Leu 
            100                 105                 110         


Thr Ile Phe Leu Asp Arg His Pro Ile Ala Phe Met Leu Cys Tyr Pro 
        115                 120                 125             


Ala Ala Arg Tyr Leu Met Gly Ser Met Thr Pro Gln Ala Val Leu Ala 
    130                 135                 140                 


Phe Val Ala Leu Ile Pro Pro Thr Leu Pro Gly Thr Asn Ile Val Leu 
145                 150                 155                 160 


Gly Ala Leu Pro Glu Asp Arg His Ile Asp Arg Leu Ala Lys Arg Gln 
                165                 170                 175     


Arg Pro Gly Glu Arg Leu Asp Leu Ala Met Leu Ala Ala Ile Arg Arg 
            180                 185                 190         


Val Tyr Gly Leu Leu Ala Asn Thr Val Arg Tyr Leu Gln Cys Gly Gly 
        195                 200                 205             


Ser Trp Arg Glu Asp Trp Gly Gln Leu Ser Gly Thr Ala Val Pro Pro 
    210                 215                 220                 


Gln Gly Ala Glu Pro Gln Ser Asn Ala Gly Pro Arg Pro His Ile Gly 
225                 230                 235                 240 


Asp Thr Leu Phe Thr Leu Phe Arg Ala Pro Glu Leu Leu Ala Pro Asn 
                245                 250                 255     


Gly Asp Leu Tyr Asn Val Phe Ala Trp Ala Leu Asp Val Leu Ala Lys 
            260                 265                 270         


Arg Leu Arg Ser Met His Val Phe Ile Leu Asp Tyr Asp Gln Ser Pro 
        275                 280                 285             


Ala Gly Cys Arg Asp Ala Leu Leu Gln Leu Thr Ser Gly Met Val Gln 
    290                 295                 300                 


Thr His Val Thr Thr Pro Gly Ser Ile Pro Thr Ile Cys Asp Leu Ala 
305                 310                 315                 320 


Arg Thr Phe Ala Arg Glu Met Gly Glu Ala Asn 
                325                 330     


<210>  72
<211>  1508
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human T cell receptor alpha chain (TRAC) mRNA sequence

<400>  72
ttttgaaacc cttcaaaggc agagacttgt ccagcctaac ctgcctgctg ctcctagctc       60

ctgaggctca gggcccttgg cttctgtccg ctctgctcag ggccctccag cgtggccact      120

gctcagccat gctcctgctg ctcgtcccag tgctcgaggt gatttttacc ctgggaggaa      180

ccagagccca gtcggtgacc cagcttggca gccacgtctc tgtctctgaa ggagccctgg      240

ttctgctgag gtgcaactac tcatcgtctg ttccaccata tctcttctgg tatgtgcaat      300

accccaacca aggactccag cttctcctga agtacacatc agcggccacc ctggttaaag      360

gcatcaacgg ttttgaggct gaatttaaga agagtgaaac ctccttccac ctgacgaaac      420

cctcagccca tatgagcgac gcggctgagt acttctgtgc tgtgagtgat ctcgaaccga      480

acagcagtgc ttccaagata atctttggat cagggaccag actcagcatc cggccaaata      540

tccagaaccc tgaccctgcc gtgtaccagc tgagagactc taaatccagt gacaagtctg      600

tctgcctatt caccgatttt gattctcaaa caaatgtgtc acaaagtaag gattctgatg      660

tgtatatcac agacaaaact gtgctagaca tgaggtctat ggacttcaag agcaacagtg      720

ctgtggcctg gagcaacaaa tctgactttg catgtgcaaa cgccttcaac aacagcatta      780

ttccagaaga caccttcttc cccagcccag aaagttcctg tgatgtcaag ctggtcgaga      840

aaagctttga aacagatacg aacctaaact ttcaaaacct gtcagtgatt gggttccgaa      900

tcctcctcct gaaagtggcc gggtttaatc tgctcatgac gctgcggctg tggtccagct      960

gagatctgca agattgtaag acagcctgtg ctccctcgct ccttcctctg cattgcccct     1020

cttctccctc tccaaacaga gggaactctc ctacccccaa ggaggtgaaa gctgctacca     1080

cctctgtgcc cccccggtaa tgccaccaac tggatcctac ccgaatttat gattaagatt     1140

gctgaagagc tgccaaacac tgctgccacc ccctctgttc ccttattgct gcttgtcact     1200

gcctgacatt cacggcagag gcaaggctgc tgcagcctcc cctggctgtg cacattccct     1260

cctgctcccc agagactgcc tccgccatcc cacagatgat ggatcttcag tgggttctct     1320

tgggctctag gtcctggaga atgttgtgag gggtttattt ttttttaata gtgttcataa     1380

agaaatacat agtattcttc ttctcaagac gtggggggaa attatctcat tatcgaggcc     1440

ctgctatgct gtgtgtctgg gcgtgttgta tgtcctgctg ccgatgcctt cattaaaatg     1500

atttggaa                                                              1508


<210>  73
<211>  2042
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human T cell receptor beta chain (TRBC1) mRNA sequence

<400>  73
tgcatcctag ggacagcata gaaaggaggg gcaaagtgga gagagagcaa cagacactgg       60

gatggtgacc ccaaaacaat gagggcctag aatgacatag ttgtgcttca ttacggccca      120

ttcccagggc tctctctcac acacacagag cccctaccag aaccagacag ctctcagagc      180

aaccctggct ccaacccctc ttccctttcc agaggacctg aacaaggtgt tcccacccga      240

ggtcgctgtg tttgagccat cagaagcaga gatctcccac acccaaaagg ccacactggt      300

gtgcctggcc acaggcttct tccccgacca cgtggagctg agctggtggg tgaatgggaa      360

ggaggtgcac agtggggtca gcacggaccc gcagcccctc aaggagcagc ccgccctcaa      420

tgactccaga tactgcctga gcagccgcct gagggtctcg gccaccttct ggcagaaccc      480

ccgcaaccac ttccgctgtc aagtccagtt ctacgggctc tcggagaatg acgagtggac      540

ccaggatagg gccaaacccg tcacccagat cgtcagcgcc gaggcctggg gtagagcagg      600

tgagtggggc ctggggagat gcctggagga gattaggtga gaccagctac cagggaaaat      660

ggaaagatcc aggtagcaga caagactaga tccaaaaaga aaggaaccag cgcacaccat      720

gaaggagaat tgggcacctg tggttcattc ttctcccaga ttctcagccc aacagagcca      780

agcagctggg tcccctttct atgtggcctg tgtaactctc atctgggtgg tgccccccat      840

ccccctcagt gctgccacat gccatggatt gcaaggacaa tgtggctgac atctgcatgg      900

cagaagaaag gaggtgctgg gctgtcagag gaagctggtc tgggcctggg agtctgtgcc      960

aactgcaaat ctgactttac ttttaattgc ctatgaaaat aaggtctctc atttattttc     1020

ctctccctgc tttctttcag actgtggctt tacctcgggt aagtaagccc ttccttttcc     1080

tctccctctc tcatggttct tgacctagaa ccaaggcatg aagaactcac agacactgga     1140

gggtggaggg tgggagagac cagagctacc tgtgcacagg tacccacctg tccttcctcc     1200

gtgccaacag tgtcctacca gcaaggggtc ctgtctgcca ccatcctcta tgagatcctg     1260

ctagggaagg ccaccctgta tgctgtgctg gtcagcgccc ttgtgttgat ggccatggta     1320

agcaggaggg caggatgggg ccagcaggct ggaggtgaca cactgacacc aagcacccag     1380

aagtatagag tccctgccag gattggagct gggcagtagg gagggaagag atttcattca     1440

ggtgcctcag aagataactt gcacctctgt aggatcacag tggaagggtc atgctgggaa     1500

ggagaagctg gagtcaccag aaaacccaat ggatgttgtg atgagcctta ctatttgtgt     1560

ggtcaatggg ccctactact ttctctcaat cctcacaact cctggctctt aataaccccc     1620

aaaactttct cttctgcagg tcaagagaaa ggatttctga aggcagccct ggaagtggag     1680

ttaggagctt ctaacccgtc atggtttcaa tacacattct tcttttgcca gcgcttctga     1740

agagctgctc tcacctctct gcatcccaat agatatcccc ctatgtgcat gcacacctgc     1800

acactcacgg ctgaaatctc cctaacccag ggggacctta gcatgcctaa gtgactaaac     1860

caataaaaat gttctggtct ggcctgactc tgacttgtga atgtctggat agctccttgg     1920

ctgtctctga actccctgtg actctcccca ttcagtcagg atagaaacaa gaggtattca     1980

aggaaaatgc agactcttca cgtaagaggg atgaggggcc caccttgaga tcaatagcag     2040

aa                                                                    2042


<210>  74
<211>  2008
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human TRBC2 T cell receptor beta constant 2 (TCRB2) sequence

<400>  74
atggcgtagt ccccaaagaa cgaggaccta gtaacataat tgtgcttcat tatggtcctt       60

tcccggcctt ctctctcaca catacacaga gcccctacca ggaccagaca gctctcagag      120

caaccctagc cccattacct cttccctttc cagaggacct gaaaaacgtg ttcccacccg      180

aggtcgctgt gtttgagcca tcagaagcag agatctccca cacccaaaag gccacactgg      240

tgtgcctggc cacaggcttc taccccgacc acgtggagct gagctggtgg gtgaatggga      300

aggaggtgca cagtggggtc agcacagacc cgcagcccct caaggagcag cccgccctca      360

atgactccag atactgcctg agcagccgcc tgagggtctc ggccaccttc tggcagaacc      420

cccgcaacca cttccgctgt caagtccagt tctacgggct ctcggagaat gacgagtgga      480

cccaggatag ggccaaacct gtcacccaga tcgtcagcgc cgaggcctgg ggtagagcag      540

gtgagtgggg cctggggaga tgcctggagg agattaggtg agaccagcta ccagggaaaa      600

tggaaagatc caggtagcgg acaagactag atccagaaga aagccagagt ggacaaggtg      660

ggatgatcaa ggttcacagg gtcagcaaag cacggtgtgc acttccccca ccaagaagca      720

tagaggctga atggagcacc tcaagctcat tcttccttca gatcctgaca ccttagagct      780

aagctttcaa gtctccctga ggaccagcca tacagctcag catctgagtg gtgtgcatcc      840

cattctcttc tggggtcctg gtttcctaag atcatagtga ccacttcgct ggcactggag      900

cagcatgagg gagacagaac cagggctatc aaaggaggct gactttgtac tatctgatat      960

gcatgtgttt gtggcctgtg agtctgtgat gtaaggctca atgtccttac aaagcagcat     1020

tctctcatcc atttttcttc ccctgttttc tttcagactg tggcttcacc tccggtaagt     1080

gagtctctcc tttttctctc tatctttcgc cgtctctgct ctcgaaccag ggcatggaga     1140

atccacggac acaggggcgt gagggaggcc agagccacct gtgcacaggt acctacatgc     1200

tctgttcttg tcaacagagt cttaccagca aggggtcctg tctgccacca tcctctatga     1260

gatcttgcta gggaaggcca ccttgtatgc cgtgctggtc agtgccctcg tgctgatggc     1320

catggtaagg aggagggtgg gatagggcag atgatggggg caggggatgg aacatcacac     1380

atgggcataa aggaatctca gagccagagc acagcctaat atatcctatc acctcaatga     1440

aaccataatg aagccagact ggggagaaaa tgcagggaat atcacagaat gcatcatggg     1500

aggatggaga caaccagcga gccctactca aattaggcct cagagcccgc ctcccctgcc     1560

ctactcctgc tgtgccatag cccctgaaac cctgaaaatg ttctctcttc cacaggtcaa     1620

gagaaaggat tccagaggct agctccaaaa ccatcccagg tcattcttca tcctcaccca     1680

ggattctcct gtacctgctc ccaatctgtg ttcctaaaag tgattctcac tctgcttctc     1740

atctcctact tacatgaata cttctctctt ttttctgttt ccctgaagat tgagctccca     1800

acccccaagt acgaaatagg ctaaaccaat aaaaaattgt gtgttgggcc tggttgcatt     1860

tcaggagtgt ctgtggagtt ctgctcatca ctgacctatc ttctgattta gggaaagcag     1920

cattcgcttg gacatctgaa gtgacagccc tctttctctc cacccaatgc tgctttctcc     1980

tgttcatcct gatggaagtc tcaacaca                                        2008


