                         SEQUENCE LISTING

<110>  NantBio
 
<120>  TNF-TYPE RECEPTOR-LIGAND FUSION PROTEINS AND METHODS

<130>  102719.0012PCT

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant or laboratory made

<400>  1

Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu His Arg Arg Leu Asp Lys Ile Glu Asp Glu Arg 
            20                  25                  30          


Asn Leu His Glu Asp Phe Val Phe Met Lys Thr Ile Gln Arg Cys Asn 
        35                  40                  45              


Thr Gly Glu Arg Ser Leu Ser Leu Leu Asn Cys Glu Glu Ile Lys Ser 
    50                  55                  60                  


Gln Phe Glu Gly Phe Val Lys Asp Ile Met Leu Asn Lys Glu Glu Thr 
65                  70                  75                  80  


Lys Lys Glu Asn Ser Phe Glu Met Gln Lys Gly Asp Gln Asn Pro Gln 
                85                  90                  95      


Ile Ala Ala His Val Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser Val 
            100                 105                 110         


Leu Gln Trp Ala Glu Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val 
        115                 120                 125             


Thr Leu Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Gln Gly Leu Tyr 
    130                 135                 140                 


Tyr Ile Tyr Ala Gln Val Thr Phe Cys Ser Asn Arg Glu Ala Ser Ser 
145                 150                 155                 160 


Gln Ala Pro Phe Ile Ala Ser Leu Cys Leu Lys Ser Pro Gly Arg Phe 
                165                 170                 175     


Glu Arg Ile Leu Leu Arg Ala Ala Asn Thr His Ser Ser Ala Lys Pro 
            180                 185                 190         


Cys Gly Gln Gln Ser Ile His Leu Gly Gly Val Phe Glu Leu Gln Pro 
        195                 200                 205             


Gly Ala Ser Val Phe Val Asn Val Thr Asp Pro Ser Gln Val Ser His 
    210                 215                 220                 


Gly Thr Gly Phe Thr Ser Phe Gly Leu Leu Lys Leu Gly Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Pro Pro Thr Ala Cys Arg Glu Lys 
                245                 250                 255     


Gln Tyr Leu Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln 
            260                 265                 270         


Lys Leu Val Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro 
        275                 280                 285             


Cys Gly Glu Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys 
    290                 295                 300                 


His Gln His Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln 
305                 310                 315                 320 


Lys Gly Thr Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp 
                325                 330                 335     


His Cys Thr Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys 
            340                 345                 350         


Ser Pro Gly Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr 
        355                 360                 365             


Ile Cys Glu Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala 
    370                 375                 380                 


Phe Glu Lys Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val 
385                 390                 395                 400 


Val Gln Gln Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Gln 
                405                 410                 415     


Asp Arg Leu Arg Ala Leu Val Val Ile Pro Ile Ile Phe Gly Ile Leu 
            420                 425                 430         


Phe Ala Ile Leu Leu Val Leu Val Phe Ile Lys Lys Val Ala Lys Lys 
        435                 440                 445             


Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn 
    450                 455                 460                 


Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu 
465                 470                 475                 480 


Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser 
                485                 490                 495     


Arg Ile Ser Val Gln Glu Arg Gln 
            500                 


<210>  2
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant or laboratory made

<400>  2

Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu His Arg Arg Leu Asp Lys Ile Glu Asp Glu Arg 
            20                  25                  30          


Asn Leu His Glu Asp Phe Val Phe Met Lys Thr Ile Gln Arg Cys Asn 
        35                  40                  45              


Thr Gly Glu Arg Ser Leu Ser Leu Leu Asn Cys Glu Glu Ile Lys Ser 
    50                  55                  60                  


Gln Phe Glu Gly Phe Val Lys Asp Ile Met Leu Asn Lys Glu Glu Thr 
65                  70                  75                  80  


Lys Lys Glu Asn Ser Phe Glu Met Gln Lys Gly Asp Gln Asn Pro Gln 
                85                  90                  95      


Ile Ala Ala His Val Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser Val 
            100                 105                 110         


Leu Gln Trp Ala Glu Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val 
        115                 120                 125             


Thr Leu Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Gln Gly Leu Tyr 
    130                 135                 140                 


Tyr Ile Tyr Ala Gln Val Thr Phe Cys Ser Asn Arg Glu Ala Ser Ser 
145                 150                 155                 160 


Gln Ala Pro Phe Ile Ala Ser Leu Cys Leu Lys Ser Pro Gly Arg Phe 
                165                 170                 175     


Glu Arg Ile Leu Leu Arg Ala Ala Asn Thr His Ser Ser Ala Lys Pro 
            180                 185                 190         


Cys Gly Gln Gln Ser Ile His Leu Gly Gly Val Phe Glu Leu Gln Pro 
        195                 200                 205             


Gly Ala Ser Val Phe Val Asn Val Thr Asp Pro Ser Gln Val Ser His 
    210                 215                 220                 


Gly Thr Gly Phe Thr Ser Phe Gly Leu Leu Lys Leu Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Pro Pro Thr Ala Cys Arg 
                245                 250                 255     


Glu Lys Gln Tyr Leu Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro 
            260                 265                 270         


Gly Gln Lys Leu Val Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys 
        275                 280                 285             


Leu Pro Cys Gly Glu Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr 
    290                 295                 300                 


His Cys His Gln His Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val 
305                 310                 315                 320 


Gln Gln Lys Gly Thr Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu 
                325                 330                 335     


Gly Trp His Cys Thr Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg 
            340                 345                 350         


Ser Cys Ser Pro Gly Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser 
        355                 360                 365             


Asp Thr Ile Cys Glu Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser 
    370                 375                 380                 


Ser Ala Phe Glu Lys Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp 
385                 390                 395                 400 


Leu Val Val Gln Gln Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly 
                405                 410                 415     


Pro Gln Asp Arg Leu Arg Ala Leu Val Val Ile Pro Ile Ile Phe Gly 
            420                 425                 430         


Ile Leu Phe Ala Ile Leu Leu Val Leu Val Phe Ile Lys Lys Val Ala 
        435                 440                 445             


Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu 
    450                 455                 460                 


Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val 
465                 470                 475                 480 


Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys 
                485                 490                 495     


Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
            500                 505     


<210>  3
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant or Laboratory made

<400>  3

Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu His Arg Arg Leu Asp Lys Ile Glu Asp Glu Arg 
            20                  25                  30          


Asn Leu His Glu Asp Phe Val Phe Met Lys Thr Ile Gln Arg Cys Asn 
        35                  40                  45              


Thr Gly Glu Arg Ser Leu Ser Leu Leu Asn Cys Glu Glu Ile Lys Ser 
    50                  55                  60                  


Gln Phe Glu Gly Phe Val Lys Asp Ile Met Leu Asn Lys Glu Glu Thr 
65                  70                  75                  80  


Lys Lys Glu Asn Ser Phe Glu Met Gln Lys Gly Asp Gln Asn Pro Gln 
                85                  90                  95      


Ile Ala Ala His Val Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser Val 
            100                 105                 110         


Leu Gln Trp Ala Glu Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val 
        115                 120                 125             


Thr Leu Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Gln Gly Leu Tyr 
    130                 135                 140                 


Tyr Ile Tyr Ala Gln Val Thr Phe Cys Ser Asn Arg Glu Ala Ser Ser 
145                 150                 155                 160 


Gln Ala Pro Phe Ile Ala Ser Leu Cys Leu Lys Ser Pro Gly Arg Phe 
                165                 170                 175     


Glu Arg Ile Leu Leu Arg Ala Ala Asn Thr His Ser Ser Ala Lys Pro 
            180                 185                 190         


Cys Gly Gln Gln Ser Ile His Leu Gly Gly Val Phe Glu Leu Gln Pro 
        195                 200                 205             


Gly Ala Ser Val Phe Val Asn Val Thr Asp Pro Ser Gln Val Ser His 
    210                 215                 220                 


Gly Thr Gly Phe Thr Ser Phe Gly Leu Leu Lys Leu Gly Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Pro Pro Thr Ala 
                245                 250                 255     


Cys Arg Glu Lys Gln Tyr Leu Ile Asn Ser Gln Cys Cys Ser Leu Cys 
            260                 265                 270         


Gln Pro Gly Gln Lys Leu Val Ser Asp Cys Thr Glu Phe Thr Glu Thr 
        275                 280                 285             


Glu Cys Leu Pro Cys Gly Glu Ser Glu Phe Leu Asp Thr Trp Asn Arg 
    290                 295                 300                 


Glu Thr His Cys His Gln His Lys Tyr Cys Asp Pro Asn Leu Gly Leu 
305                 310                 315                 320 


Arg Val Gln Gln Lys Gly Thr Ser Glu Thr Asp Thr Ile Cys Thr Cys 
                325                 330                 335     


Glu Glu Gly Trp His Cys Thr Ser Glu Ala Cys Glu Ser Cys Val Leu 
            340                 345                 350         


His Arg Ser Cys Ser Pro Gly Phe Gly Val Lys Gln Ile Ala Thr Gly 
        355                 360                 365             


Val Ser Asp Thr Ile Cys Glu Pro Cys Pro Val Gly Phe Phe Ser Asn 
    370                 375                 380                 


Val Ser Ser Ala Phe Glu Lys Cys His Pro Trp Thr Ser Cys Glu Thr 
385                 390                 395                 400 


Lys Asp Leu Val Val Gln Gln Ala Gly Thr Asn Lys Thr Asp Val Val 
                405                 410                 415     


Cys Gly Pro Gln Asp Arg Leu Arg Ala Leu Val Val Ile Pro Ile Ile 
            420                 425                 430         


Phe Gly Ile Leu Phe Ala Ile Leu Leu Val Leu Val Phe Ile Lys Lys 
        435                 440                 445             


Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro 
    450                 455                 460                 


Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala 
465                 470                 475                 480 


Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp 
                485                 490                 495     


Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
            500                 505             


<210>  4
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant or Laboratory made

<400>  4

Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu His Arg Arg Leu Asp Lys Ile Glu Asp Glu Arg 
            20                  25                  30          


Asn Leu His Glu Asp Phe Val Phe Met Lys Thr Ile Gln Arg Cys Asn 
        35                  40                  45              


Thr Gly Glu Arg Ser Leu Ser Leu Leu Asn Cys Glu Glu Ile Lys Ser 
    50                  55                  60                  


Gln Phe Glu Gly Phe Val Lys Asp Ile Met Leu Asn Lys Glu Glu Thr 
65                  70                  75                  80  


Lys Lys Glu Asn Ser Phe Glu Met Gln Lys Gly Asp Gln Asn Pro Gln 
                85                  90                  95      


Ile Ala Ala His Val Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser Val 
            100                 105                 110         


Leu Gln Trp Ala Glu Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val 
        115                 120                 125             


Thr Leu Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Gln Gly Leu Tyr 
    130                 135                 140                 


Tyr Ile Tyr Ala Gln Val Thr Phe Cys Ser Asn Arg Glu Ala Ser Ser 
145                 150                 155                 160 


Gln Ala Pro Phe Ile Ala Ser Leu Cys Leu Lys Ser Pro Gly Arg Phe 
                165                 170                 175     


Glu Arg Ile Leu Leu Arg Ala Ala Asn Thr His Ser Ser Ala Lys Pro 
            180                 185                 190         


Cys Gly Gln Gln Ser Ile His Leu Gly Gly Val Phe Glu Leu Gln Pro 
        195                 200                 205             


Gly Ala Ser Val Phe Val Asn Val Thr Asp Pro Ser Gln Val Ser His 
    210                 215                 220                 


Gly Thr Gly Phe Thr Ser Phe Gly Leu Leu Lys Leu Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Pro Pro 
                245                 250                 255     


Thr Ala Cys Arg Glu Lys Gln Tyr Leu Ile Asn Ser Gln Cys Cys Ser 
            260                 265                 270         


Leu Cys Gln Pro Gly Gln Lys Leu Val Ser Asp Cys Thr Glu Phe Thr 
        275                 280                 285             


Glu Thr Glu Cys Leu Pro Cys Gly Glu Ser Glu Phe Leu Asp Thr Trp 
    290                 295                 300                 


Asn Arg Glu Thr His Cys His Gln His Lys Tyr Cys Asp Pro Asn Leu 
305                 310                 315                 320 


Gly Leu Arg Val Gln Gln Lys Gly Thr Ser Glu Thr Asp Thr Ile Cys 
                325                 330                 335     


Thr Cys Glu Glu Gly Trp His Cys Thr Ser Glu Ala Cys Glu Ser Cys 
            340                 345                 350         


Val Leu His Arg Ser Cys Ser Pro Gly Phe Gly Val Lys Gln Ile Ala 
        355                 360                 365             


Thr Gly Val Ser Asp Thr Ile Cys Glu Pro Cys Pro Val Gly Phe Phe 
    370                 375                 380                 


Ser Asn Val Ser Ser Ala Phe Glu Lys Cys His Pro Trp Thr Ser Cys 
385                 390                 395                 400 


Glu Thr Lys Asp Leu Val Val Gln Gln Ala Gly Thr Asn Lys Thr Asp 
                405                 410                 415     


Val Val Cys Gly Pro Gln Asp Arg Leu Arg Ala Leu Val Val Ile Pro 
            420                 425                 430         


Ile Ile Phe Gly Ile Leu Phe Ala Ile Leu Leu Val Leu Val Phe Ile 
        435                 440                 445             


Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln 
    450                 455                 460                 


Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr 
465                 470                 475                 480 


Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln 
                485                 490                 495     


Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
            500                 505                 510 


<210>  5
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant or Laboratory made

<400>  5

Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu His Arg Arg Leu Asp Lys Ile Glu Asp Glu Arg 
            20                  25                  30          


Asn Leu His Glu Asp Phe Val Phe Met Lys Thr Ile Gln Arg Cys Asn 
        35                  40                  45              


Thr Gly Glu Arg Ser Leu Ser Leu Leu Asn Cys Glu Glu Ile Lys Ser 
    50                  55                  60                  


Gln Phe Glu Gly Phe Val Lys Asp Ile Met Leu Asn Lys Glu Glu Thr 
65                  70                  75                  80  


Lys Lys Glu Asn Ser Phe Glu Met Gln Lys Gly Asp Gln Asn Pro Gln 
                85                  90                  95      


Ile Ala Ala His Val Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser Val 
            100                 105                 110         


Leu Gln Trp Ala Glu Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val 
        115                 120                 125             


Thr Leu Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Gln Gly Leu Tyr 
    130                 135                 140                 


Tyr Ile Tyr Ala Gln Val Thr Phe Cys Ser Asn Arg Glu Ala Ser Ser 
145                 150                 155                 160 


Gln Ala Pro Phe Ile Ala Ser Leu Cys Leu Lys Ser Pro Gly Arg Phe 
                165                 170                 175     


Glu Arg Ile Leu Leu Arg Ala Ala Asn Thr His Ser Ser Ala Lys Pro 
            180                 185                 190         


Cys Gly Gln Gln Ser Ile His Leu Gly Gly Val Phe Glu Leu Gln Pro 
        195                 200                 205             


Gly Ala Ser Val Phe Val Asn Val Thr Asp Pro Ser Gln Val Ser His 
    210                 215                 220                 


Gly Thr Gly Phe Thr Ser Phe Gly Leu Leu Lys Leu Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu Ile Asn Ser Gln Cys 
            260                 265                 270         


Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val Ser Asp Cys Thr Glu 
        275                 280                 285             


Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu Ser Glu Phe Leu Asp 
    290                 295                 300                 


Thr Trp Asn Arg Glu Thr His Cys His Gln His Lys Tyr Cys Asp Pro 
305                 310                 315                 320 


Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr Ser Glu Thr Asp Thr 
                325                 330                 335     


Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr Ser Glu Ala Cys Glu 
            340                 345                 350         


Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly Phe Gly Val Lys Gln 
        355                 360                 365             


Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu Pro Cys Pro Val Gly 
    370                 375                 380                 


Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys Cys His Pro Trp Thr 
385                 390                 395                 400 


Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln Ala Gly Thr Asn Lys 
                405                 410                 415     


Thr Asp Val Val Cys Gly Pro Gln Asp Arg Leu Arg Ala Leu Val Val 
            420                 425                 430         


Ile Pro Ile Ile Phe Gly Ile Leu Phe Ala Ile Leu Leu Val Leu Val 
        435                 440                 445             


Phe Ile Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro 
    450                 455                 460                 


Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser 
465                 470                 475                 480 


Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val 
                485                 490                 495     


Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
            500                 505                 510         


<210>  6
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant or laboratory made

<400>  6

Met Val Ser Leu Pro Arg Leu Cys Ala Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Leu His Arg Arg Leu Asp Lys Val Glu Glu Glu Val Asn 
            20                  25                  30          


Leu His Glu Asp Phe Val Phe Ile Lys Lys Leu Lys Arg Cys Asn Lys 
        35                  40                  45              


Gly Glu Gly Ser Leu Ser Leu Leu Asn Cys Glu Glu Met Arg Arg Gln 
    50                  55                  60                  


Phe Glu Asp Leu Val Lys Asp Ile Thr Leu Asn Lys Glu Glu Lys Lys 
65                  70                  75                  80  


Glu Asn Ser Phe Glu Met Gln Arg Gly Asp Glu Asp Pro Gln Ile Ala 
                85                  90                  95      


Ala His Val Val Ser Glu Ala Asn Ser Asn Ala Ala Ser Val Leu Gln 
            100                 105                 110         


Trp Ala Lys Lys Gly Tyr Tyr Thr Met Lys Ser Asn Leu Val Met Leu 
        115                 120                 125             


Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Glu Gly Leu Tyr Tyr Val 
    130                 135                 140                 


Tyr Thr Gln Val Thr Phe Cys Ser Asn Arg Glu Pro Ser Ser Gln Arg 
145                 150                 155                 160 


Pro Phe Ile Val Gly Leu Trp Leu Lys Pro Ser Ser Gly Ser Glu Arg 
                165                 170                 175     


Ile Leu Leu Lys Ala Ala Asn Thr His Ser Ser Ser Gln Leu Cys Glu 
            180                 185                 190         


Gln Gln Ser Val His Leu Gly Gly Val Phe Glu Leu Gln Ala Gly Ala 
        195                 200                 205             


Ser Val Phe Val Asn Val Thr Glu Ala Ser Gln Val Ile His Arg Val 
    210                 215                 220                 


Gly Phe Ser Ser Phe Gly Leu Leu Lys Leu Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Gln Cys Val Thr Cys Ser Asp Lys Gln 
                245                 250                 255     


Tyr Leu His Asp Gly Gln Cys Cys Asp Leu Cys Gln Pro Gly Ser Arg 
            260                 265                 270         


Leu Thr Ser His Cys Thr Ala Leu Glu Lys Thr Gln Cys His Pro Cys 
        275                 280                 285             


Asp Ser Gly Glu Phe Ser Ala Gln Trp Asn Arg Glu Ile Arg Cys His 
    290                 295                 300                 


Gln His Arg His Cys Glu Pro Asn Gln Gly Leu Arg Val Lys Lys Glu 
305                 310                 315                 320 


Gly Thr Ala Glu Ser Asp Thr Val Cys Thr Cys Lys Glu Gly Gln His 
                325                 330                 335     


Cys Thr Ser Lys Asp Cys Glu Ala Cys Ala Gln His Thr Pro Cys Ile 
            340                 345                 350         


Pro Gly Phe Gly Val Met Glu Met Ala Thr Glu Thr Thr Asp Thr Val 
        355                 360                 365             


Cys His Pro Cys Pro Val Gly Phe Phe Ser Asn Gln Ser Ser Leu Phe 
    370                 375                 380                 


Glu Lys Cys Tyr Pro Trp Thr Ser Cys Glu Asp Lys Asn Leu Glu Val 
385                 390                 395                 400 


Leu Gln Lys Gly Thr Ser Gln Thr Asn Val Ile Cys Gly Leu Lys Ser 
                405                 410                 415     


Arg Met Arg Ala Leu Leu Val Ile Pro Val Val Met Gly Ile Leu Ile 
            420                 425                 430         


Thr Ile Phe Gly Val Phe Leu Tyr Ile Lys Lys Val Val Lys Lys Pro 
        435                 440                 445             


Lys Asp Asn Glu Ile Leu Pro Pro Ala Ala Arg Arg Gln Asp Pro Gln 
    450                 455                 460                 


Glu Met Glu Asp Tyr Pro Gly His Asn Thr Ala Ala Pro Val Gln Glu 
465                 470                 475                 480 


Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser 
                485                 490                 495     


Arg Ile Ser Val Gln Glu Arg Gln Val Thr Asp Ser Ile Ala Leu Arg 
            500                 505                 510         


Pro Leu Val 
        515 


<210>  7
<211>  517
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant or laboratory made

<400>  7

Met Val Ser Leu Pro Arg Leu Cys Ala Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Leu His Arg Arg Leu Asp Lys Val Glu Glu Glu Val Asn 
            20                  25                  30          


Leu His Glu Asp Phe Val Phe Ile Lys Lys Leu Lys Arg Cys Asn Lys 
        35                  40                  45              


Gly Glu Gly Ser Leu Ser Leu Leu Asn Cys Glu Glu Met Arg Arg Gln 
    50                  55                  60                  


Phe Glu Asp Leu Val Lys Asp Ile Thr Leu Asn Lys Glu Glu Lys Lys 
65                  70                  75                  80  


Glu Asn Ser Phe Glu Met Gln Arg Gly Asp Glu Asp Pro Gln Ile Ala 
                85                  90                  95      


Ala His Val Val Ser Glu Ala Asn Ser Asn Ala Ala Ser Val Leu Gln 
            100                 105                 110         


Trp Ala Lys Lys Gly Tyr Tyr Thr Met Lys Ser Asn Leu Val Met Leu 
        115                 120                 125             


Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Glu Gly Leu Tyr Tyr Val 
    130                 135                 140                 


Tyr Thr Gln Val Thr Phe Cys Ser Asn Arg Glu Pro Ser Ser Gln Arg 
145                 150                 155                 160 


Pro Phe Ile Val Gly Leu Trp Leu Lys Pro Ser Ser Gly Ser Glu Arg 
                165                 170                 175     


Ile Leu Leu Lys Ala Ala Asn Thr His Ser Ser Ser Gln Leu Cys Glu 
            180                 185                 190         


Gln Gln Ser Val His Leu Gly Gly Val Phe Glu Leu Gln Ala Gly Ala 
        195                 200                 205             


Ser Val Phe Val Asn Val Thr Glu Ala Ser Gln Val Ile His Arg Val 
    210                 215                 220                 


Gly Phe Ser Ser Phe Gly Leu Leu Lys Leu Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Gly Gln Cys Val Thr Cys Ser Asp 
                245                 250                 255     


Lys Gln Tyr Leu His Asp Gly Gln Cys Cys Asp Leu Cys Gln Pro Gly 
            260                 265                 270         


Ser Arg Leu Thr Ser His Cys Thr Ala Leu Glu Lys Thr Gln Cys His 
        275                 280                 285             


Pro Cys Asp Ser Gly Glu Phe Ser Ala Gln Trp Asn Arg Glu Ile Arg 
    290                 295                 300                 


Cys His Gln His Arg His Cys Glu Pro Asn Gln Gly Leu Arg Val Lys 
305                 310                 315                 320 


Lys Glu Gly Thr Ala Glu Ser Asp Thr Val Cys Thr Cys Lys Glu Gly 
                325                 330                 335     


Gln His Cys Thr Ser Lys Asp Cys Glu Ala Cys Ala Gln His Thr Pro 
            340                 345                 350         


Cys Ile Pro Gly Phe Gly Val Met Glu Met Ala Thr Glu Thr Thr Asp 
        355                 360                 365             


Thr Val Cys His Pro Cys Pro Val Gly Phe Phe Ser Asn Gln Ser Ser 
    370                 375                 380                 


Leu Phe Glu Lys Cys Tyr Pro Trp Thr Ser Cys Glu Asp Lys Asn Leu 
385                 390                 395                 400 


Glu Val Leu Gln Lys Gly Thr Ser Gln Thr Asn Val Ile Cys Gly Leu 
                405                 410                 415     


Lys Ser Arg Met Arg Ala Leu Leu Val Ile Pro Val Val Met Gly Ile 
            420                 425                 430         


Leu Ile Thr Ile Phe Gly Val Phe Leu Tyr Ile Lys Lys Val Val Lys 
        435                 440                 445             


Lys Pro Lys Asp Asn Glu Ile Leu Pro Pro Ala Ala Arg Arg Gln Asp 
    450                 455                 460                 


Pro Gln Glu Met Glu Asp Tyr Pro Gly His Asn Thr Ala Ala Pro Val 
465                 470                 475                 480 


Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys 
                485                 490                 495     


Glu Ser Arg Ile Ser Val Gln Glu Arg Gln Val Thr Asp Ser Ile Ala 
            500                 505                 510         


Leu Arg Pro Leu Val 
        515         


<210>  8
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant or laboratory made

<400>  8

Met Val Ser Leu Pro Arg Leu Cys Ala Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Leu His Arg Arg Leu Asp Lys Val Glu Glu Glu Val Asn 
            20                  25                  30          


Leu His Glu Asp Phe Val Phe Ile Lys Lys Leu Lys Arg Cys Asn Lys 
        35                  40                  45              


Gly Glu Gly Ser Leu Ser Leu Leu Asn Cys Glu Glu Met Arg Arg Gln 
    50                  55                  60                  


Phe Glu Asp Leu Val Lys Asp Ile Thr Leu Asn Lys Glu Glu Lys Lys 
65                  70                  75                  80  


Glu Asn Ser Phe Glu Met Gln Arg Gly Asp Glu Asp Pro Gln Ile Ala 
                85                  90                  95      


Ala His Val Val Ser Glu Ala Asn Ser Asn Ala Ala Ser Val Leu Gln 
            100                 105                 110         


Trp Ala Lys Lys Gly Tyr Tyr Thr Met Lys Ser Asn Leu Val Met Leu 
        115                 120                 125             


Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Glu Gly Leu Tyr Tyr Val 
    130                 135                 140                 


Tyr Thr Gln Val Thr Phe Cys Ser Asn Arg Glu Pro Ser Ser Gln Arg 
145                 150                 155                 160 


Pro Phe Ile Val Gly Leu Trp Leu Lys Pro Ser Ser Gly Ser Glu Arg 
                165                 170                 175     


Ile Leu Leu Lys Ala Ala Asn Thr His Ser Ser Ser Gln Leu Cys Glu 
            180                 185                 190         


Gln Gln Ser Val His Leu Gly Gly Val Phe Glu Leu Gln Ala Gly Ala 
        195                 200                 205             


Ser Val Phe Val Asn Val Thr Glu Ala Ser Gln Val Ile His Arg Val 
    210                 215                 220                 


Gly Phe Ser Ser Phe Gly Leu Leu Lys Leu Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gln Cys Val Thr Cys 
                245                 250                 255     


Ser Asp Lys Gln Tyr Leu His Asp Gly Gln Cys Cys Asp Leu Cys Gln 
            260                 265                 270         


Pro Gly Ser Arg Leu Thr Ser His Cys Thr Ala Leu Glu Lys Thr Gln 
        275                 280                 285             


Cys His Pro Cys Asp Ser Gly Glu Phe Ser Ala Gln Trp Asn Arg Glu 
    290                 295                 300                 


Ile Arg Cys His Gln His Arg His Cys Glu Pro Asn Gln Gly Leu Arg 
305                 310                 315                 320 


Val Lys Lys Glu Gly Thr Ala Glu Ser Asp Thr Val Cys Thr Cys Lys 
                325                 330                 335     


Glu Gly Gln His Cys Thr Ser Lys Asp Cys Glu Ala Cys Ala Gln His 
            340                 345                 350         


Thr Pro Cys Ile Pro Gly Phe Gly Val Met Glu Met Ala Thr Glu Thr 
        355                 360                 365             


Thr Asp Thr Val Cys His Pro Cys Pro Val Gly Phe Phe Ser Asn Gln 
    370                 375                 380                 


Ser Ser Leu Phe Glu Lys Cys Tyr Pro Trp Thr Ser Cys Glu Asp Lys 
385                 390                 395                 400 


Asn Leu Glu Val Leu Gln Lys Gly Thr Ser Gln Thr Asn Val Ile Cys 
                405                 410                 415     


Gly Leu Lys Ser Arg Met Arg Ala Leu Leu Val Ile Pro Val Val Met 
            420                 425                 430         


Gly Ile Leu Ile Thr Ile Phe Gly Val Phe Leu Tyr Ile Lys Lys Val 
        435                 440                 445             


Val Lys Lys Pro Lys Asp Asn Glu Ile Leu Pro Pro Ala Ala Arg Arg 
    450                 455                 460                 


Gln Asp Pro Gln Glu Met Glu Asp Tyr Pro Gly His Asn Thr Ala Ala 
465                 470                 475                 480 


Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp 
                485                 490                 495     


Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln Val Thr Asp Ser 
            500                 505                 510         


Ile Ala Leu Arg Pro Leu Val 
        515                 


<210>  9
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant or laboratory made

<400>  9

Met Val Ser Leu Pro Arg Leu Cys Ala Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Leu His Arg Arg Leu Asp Lys Val Glu Glu Glu Val Asn 
            20                  25                  30          


Leu His Glu Asp Phe Val Phe Ile Lys Lys Leu Lys Arg Cys Asn Lys 
        35                  40                  45              


Gly Glu Gly Ser Leu Ser Leu Leu Asn Cys Glu Glu Met Arg Arg Gln 
    50                  55                  60                  


Phe Glu Asp Leu Val Lys Asp Ile Thr Leu Asn Lys Glu Glu Lys Lys 
65                  70                  75                  80  


Glu Asn Ser Phe Glu Met Gln Arg Gly Asp Glu Asp Pro Gln Ile Ala 
                85                  90                  95      


Ala His Val Val Ser Glu Ala Asn Ser Asn Ala Ala Ser Val Leu Gln 
            100                 105                 110         


Trp Ala Lys Lys Gly Tyr Tyr Thr Met Lys Ser Asn Leu Val Met Leu 
        115                 120                 125             


Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Glu Gly Leu Tyr Tyr Val 
    130                 135                 140                 


Tyr Thr Gln Val Thr Phe Cys Ser Asn Arg Glu Pro Ser Ser Gln Arg 
145                 150                 155                 160 


Pro Phe Ile Val Gly Leu Trp Leu Lys Pro Ser Ser Gly Ser Glu Arg 
                165                 170                 175     


Ile Leu Leu Lys Ala Ala Asn Thr His Ser Ser Ser Gln Leu Cys Glu 
            180                 185                 190         


Gln Gln Ser Val His Leu Gly Gly Val Phe Glu Leu Gln Ala Gly Ala 
        195                 200                 205             


Ser Val Phe Val Asn Val Thr Glu Ala Ser Gln Val Ile His Arg Val 
    210                 215                 220                 


Gly Phe Ser Ser Phe Gly Leu Leu Lys Leu Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gln Cys Val 
                245                 250                 255     


Thr Cys Ser Asp Lys Gln Tyr Leu His Asp Gly Gln Cys Cys Asp Leu 
            260                 265                 270         


Cys Gln Pro Gly Ser Arg Leu Thr Ser His Cys Thr Ala Leu Glu Lys 
        275                 280                 285             


Thr Gln Cys His Pro Cys Asp Ser Gly Glu Phe Ser Ala Gln Trp Asn 
    290                 295                 300                 


Arg Glu Ile Arg Cys His Gln His Arg His Cys Glu Pro Asn Gln Gly 
305                 310                 315                 320 


Leu Arg Val Lys Lys Glu Gly Thr Ala Glu Ser Asp Thr Val Cys Thr 
                325                 330                 335     


Cys Lys Glu Gly Gln His Cys Thr Ser Lys Asp Cys Glu Ala Cys Ala 
            340                 345                 350         


Gln His Thr Pro Cys Ile Pro Gly Phe Gly Val Met Glu Met Ala Thr 
        355                 360                 365             


Glu Thr Thr Asp Thr Val Cys His Pro Cys Pro Val Gly Phe Phe Ser 
    370                 375                 380                 


Asn Gln Ser Ser Leu Phe Glu Lys Cys Tyr Pro Trp Thr Ser Cys Glu 
385                 390                 395                 400 


Asp Lys Asn Leu Glu Val Leu Gln Lys Gly Thr Ser Gln Thr Asn Val 
                405                 410                 415     


Ile Cys Gly Leu Lys Ser Arg Met Arg Ala Leu Leu Val Ile Pro Val 
            420                 425                 430         


Val Met Gly Ile Leu Ile Thr Ile Phe Gly Val Phe Leu Tyr Ile Lys 
        435                 440                 445             


Lys Val Val Lys Lys Pro Lys Asp Asn Glu Ile Leu Pro Pro Ala Ala 
    450                 455                 460                 


Arg Arg Gln Asp Pro Gln Glu Met Glu Asp Tyr Pro Gly His Asn Thr 
465                 470                 475                 480 


Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln 
                485                 490                 495     


Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln Val Thr 
            500                 505                 510         


Asp Ser Ile Ala Leu Arg Pro Leu Val 
        515                 520     


<210>  10
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant or laboratory made

<400>  10

Met Val Ser Leu Pro Arg Leu Cys Ala Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Leu His Arg Arg Leu Asp Lys Val Glu Glu Glu Val Asn 
            20                  25                  30          


Leu His Glu Asp Phe Val Phe Ile Lys Lys Leu Lys Arg Cys Asn Lys 
        35                  40                  45              


Gly Glu Gly Ser Leu Ser Leu Leu Asn Cys Glu Glu Met Arg Arg Gln 
    50                  55                  60                  


Phe Glu Asp Leu Val Lys Asp Ile Thr Leu Asn Lys Glu Glu Lys Lys 
65                  70                  75                  80  


Glu Asn Ser Phe Glu Met Gln Arg Gly Asp Glu Asp Pro Gln Ile Ala 
                85                  90                  95      


Ala His Val Val Ser Glu Ala Asn Ser Asn Ala Ala Ser Val Leu Gln 
            100                 105                 110         


Trp Ala Lys Lys Gly Tyr Tyr Thr Met Lys Ser Asn Leu Val Met Leu 
        115                 120                 125             


Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Glu Gly Leu Tyr Tyr Val 
    130                 135                 140                 


Tyr Thr Gln Val Thr Phe Cys Ser Asn Arg Glu Pro Ser Ser Gln Arg 
145                 150                 155                 160 


Pro Phe Ile Val Gly Leu Trp Leu Lys Pro Ser Ser Gly Ser Glu Arg 
                165                 170                 175     


Ile Leu Leu Lys Ala Ala Asn Thr His Ser Ser Ser Gln Leu Cys Glu 
            180                 185                 190         


Gln Gln Ser Val His Leu Gly Gly Val Phe Glu Leu Gln Ala Gly Ala 
        195                 200                 205             


Ser Val Phe Val Asn Val Thr Glu Ala Ser Gln Val Ile His Arg Val 
    210                 215                 220                 


Gly Phe Ser Ser Phe Gly Leu Leu Lys Leu Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gln 
                245                 250                 255     


Cys Val Thr Cys Ser Asp Lys Gln Tyr Leu His Asp Gly Gln Cys Cys 
            260                 265                 270         


Asp Leu Cys Gln Pro Gly Ser Arg Leu Thr Ser His Cys Thr Ala Leu 
        275                 280                 285             


Glu Lys Thr Gln Cys His Pro Cys Asp Ser Gly Glu Phe Ser Ala Gln 
    290                 295                 300                 


Trp Asn Arg Glu Ile Arg Cys His Gln His Arg His Cys Glu Pro Asn 
305                 310                 315                 320 


Gln Gly Leu Arg Val Lys Lys Glu Gly Thr Ala Glu Ser Asp Thr Val 
                325                 330                 335     


Cys Thr Cys Lys Glu Gly Gln His Cys Thr Ser Lys Asp Cys Glu Ala 
            340                 345                 350         


Cys Ala Gln His Thr Pro Cys Ile Pro Gly Phe Gly Val Met Glu Met 
        355                 360                 365             


Ala Thr Glu Thr Thr Asp Thr Val Cys His Pro Cys Pro Val Gly Phe 
    370                 375                 380                 


Phe Ser Asn Gln Ser Ser Leu Phe Glu Lys Cys Tyr Pro Trp Thr Ser 
385                 390                 395                 400 


Cys Glu Asp Lys Asn Leu Glu Val Leu Gln Lys Gly Thr Ser Gln Thr 
                405                 410                 415     


Asn Val Ile Cys Gly Leu Lys Ser Arg Met Arg Ala Leu Leu Val Ile 
            420                 425                 430         


Pro Val Val Met Gly Ile Leu Ile Thr Ile Phe Gly Val Phe Leu Tyr 
        435                 440                 445             


Ile Lys Lys Val Val Lys Lys Pro Lys Asp Asn Glu Ile Leu Pro Pro 
    450                 455                 460                 


Ala Ala Arg Arg Gln Asp Pro Gln Glu Met Glu Asp Tyr Pro Gly His 
465                 470                 475                 480 


Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val 
                485                 490                 495     


Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
            500                 505                 510         


Val Thr Asp Ser Ile Ala Leu Arg Pro Leu Val 
        515                 520             


