                         SEQUENCE LISTING

<110>  bluebird bio, Inc.
       Friedman, Kevin
       Perkins, Molly Reed
 
<120>  CD79B CHIMERIC ANTIGEN RECEPTORS

<130>  BLBD-101/01WO 315698-2948

<150>  US 62/685,084
<151>  2018-06-14

<160>  93    

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Light chain CDR1

<400>  1

Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Gly Tyr Met Asp 
1               5                   10                  15  


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Light chain CDR2

<400>  2

Ala Ala Ser Asn Leu Lys Ser 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Light Chain CDR3

<400>  3

Gln Gln Thr Asn Glu Tyr Pro Trp Thr 
1               5                   


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Heavy chain CDR1

<400>  4

Gly Tyr Thr Phe Thr Asp Tyr Ser Met His 
1               5                   10  


<210>  5
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Heavy chain CDR2

<400>  5

Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Heavy chain CDR6

<400>  6

Gly Ser Tyr 
1           


<210>  7
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Varialble light chain

<400>  7

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Gly Tyr Met Asp Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Phe Ala Ala Ser Asn Leu Lys Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Thr Asn 
                85                  90                  95      


Glu Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  8
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Variable heavy chain

<400>  8

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Met His Trp Val Lys Gln Ala Pro Gly Glu Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Tyr Tyr Gly Ser Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110     


<210>  9
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Light chain CDR1

<400>  9

Lys Ala Ser Gln Ser Val Asp Tyr Glu Gly Asp Ser Phe Leu Asn 
1               5                   10                  15  


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Light chain CDR2

<400>  10

Ala Ala Ser Asn Leu Glu Ser 
1               5           


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Light Chain CDR3

<400>  11

Gln Gln Ser Asn Glu Asp Pro Leu Thr 
1               5                   


<210>  12
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Heavy chain CDR1

<400>  12

Gly Tyr Thr Phe Ser Ser Tyr Trp Ile Glu 
1               5                   10  


<210>  13
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Heavy chain CDR2

<400>  13

Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr Asn Glu Ile Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Heavy chain CDR6

<400>  14

Arg Val Pro Ile Arg Leu Asp Tyr 
1               5               


<210>  15
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Varialble light chain

<400>  15

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp Tyr Glu 
            20                  25                  30          


Gly Asp Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  16
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Variable heavy chain

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr Asn Glu Ile Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Phe Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Arg Val Pro Ile Arg Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  17
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Light chain CDR1

<400>  17

Lys Ser Ser Gln Ser Leu Leu Asp Thr Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Light chain CDR2

<400>  18

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Light Chain CDR3

<400>  19

Trp Gln Gly Thr His Phe Pro Leu Thr 
1               5                   


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Heavy chain CDR1

<400>  20

Gly Tyr Thr Phe Thr Ser Tyr Trp Met Asn 
1               5                   10  


<210>  21
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Heavy chain CDR2

<400>  21

Met Val Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Met Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  22
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Heavy chain CDR6

<400>  22

Ala Met Gly Tyr 
1               


<210>  23
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Varialble light chain

<400>  23

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Asn Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Thr 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Asn Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  24
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Variable heavy chain

<400>  24

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gln Ser 
1               5                   10                  15      


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp 
            20                  25                  30          


Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Met Val Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Met Phe Lys 
    50                  55                  60                  


Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Met Gly Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
            100                 105                 110         


<210>  25
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Light chain CDR1

<400>  25

Lys Ser Ser Gln Ser Leu Leu Asp Thr Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  26
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Light chain CDR2

<400>  26

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Light Chain CDR3

<400>  27

Trp Gln Gly Thr His Phe Pro Leu Thr 
1               5                   


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Heavy chain CDR1

<400>  28

Gly Tyr Thr Phe Thr Ser Tyr Trp Met Asn 
1               5                   10  


<210>  29
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Heavy chain CDR2

<400>  29

Met Val Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Met Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  30
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Heavy chain CDR6

<400>  30

Ala Met Gly Tyr 
1               


<210>  31
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Varialble light chain

<400>  31

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Asn Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Thr 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Asn Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  32
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Variable heavy chain

<400>  32

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gln Ser 
1               5                   10                  15      


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp 
            20                  25                  30          


Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Met Val Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Met Phe Lys 
    50                  55                  60                  


Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Met Gly Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
            100                 105                 110         


<210>  33
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79B-06_HL CAR construct

<400>  33

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Asp Tyr Ser Met His Trp Val Lys Gln Ala Pro Gly Glu 
    50                  55                  60                  


Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr 
65                  70                  75                  80  


Tyr Ala Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser 
                85                  90                  95      


Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr 
            100                 105                 110         


Ala Thr Tyr Phe Cys Tyr Tyr Gly Ser Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
145                 150                 155                 160 


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser 
                165                 170                 175     


Val Asp Tyr Asp Gly Asp Gly Tyr Met Asp Trp Tyr Gln Gln Lys Pro 
            180                 185                 190         


Gly Gln Pro Pro Lys Leu Leu Ile Phe Ala Ala Ser Asn Leu Lys Ser 
        195                 200                 205             


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
    210                 215                 220                 


Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys 
225                 230                 235                 240 


Gln Gln Thr Asn Glu Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
                245                 250                 255     


Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
            260                 265                 270         


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
        275                 280                 285             


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
    290                 295                 300                 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
305                 310                 315                 320 


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
                325                 330                 335     


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
            340                 345                 350         


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
        355                 360                 365             


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
    370                 375                 380                 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
385                 390                 395                 400 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                405                 410                 415     


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            420                 425                 430         


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        435                 440                 445             


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    450                 455                 460                 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
465                 470                 475                 480 


Pro Arg 
        


<210>  34
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79B-06_LH CAR construct

<400>  34

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu 
            20                  25                  30          


Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln 
        35                  40                  45              


Ser Val Asp Tyr Asp Gly Asp Gly Tyr Met Asp Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Phe Ala Ala Ser Asn Leu Lys 
65                  70                  75                  80  


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr 
            100                 105                 110         


Cys Gln Gln Thr Asn Glu Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys 
145                 150                 155                 160 


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
                165                 170                 175     


Thr Asp Tyr Ser Met His Trp Val Lys Gln Ala Pro Gly Glu Gly Leu 
            180                 185                 190         


Lys Trp Met Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala 
        195                 200                 205             


Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser 
    210                 215                 220                 


Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr 
225                 230                 235                 240 


Tyr Phe Cys Tyr Tyr Gly Ser Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                245                 250                 255     


Val Ser Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
            260                 265                 270         


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
        275                 280                 285             


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
    290                 295                 300                 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
305                 310                 315                 320 


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
                325                 330                 335     


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
            340                 345                 350         


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
        355                 360                 365             


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
    370                 375                 380                 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
385                 390                 395                 400 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                405                 410                 415     


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            420                 425                 430         


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        435                 440                 445             


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    450                 455                 460                 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
465                 470                 475                 480 


Pro Arg 
        


<210>  35
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79B-08_HL CAR construct

<400>  35

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Ser Ser Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn 
65                  70                  75                  80  


Tyr Asn Glu Ile Phe Lys Gly Arg Ala Thr Phe Ser Ala Asp Thr Ser 
                85                  90                  95      


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Arg Arg Val Pro Ile Arg Leu Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser 
145                 150                 155                 160 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                165                 170                 175     


Lys Ala Ser Gln Ser Val Asp Tyr Glu Gly Asp Ser Phe Leu Asn Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala 
        195                 200                 205             


Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Leu Thr Phe Gly 
                245                 250                 255     


Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg 
                485             


<210>  36
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79B-08_LH CAR consstruct

<400>  36

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln 
        35                  40                  45              


Ser Val Asp Tyr Glu Gly Asp Ser Phe Leu Asn Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu 
65                  70                  75                  80  


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
            100                 105                 110         


Cys Gln Gln Ser Asn Glu Asp Pro Leu Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
145                 150                 155                 160 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr 
                165                 170                 175     


Phe Ser Ser Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly 
            180                 185                 190         


Leu Glu Trp Ile Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr 
        195                 200                 205             


Asn Glu Ile Phe Lys Gly Arg Ala Thr Phe Ser Ala Asp Thr Ser Lys 
    210                 215                 220                 


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Thr Arg Arg Val Pro Ile Arg Leu Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
305                 310                 315                 320 


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg 
                485             


<210>  37
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79B-15_HL CAR construct

<400>  37

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu 
            20                  25                  30          


Val Arg Pro Gln Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Met Val Asp Pro Ser Asp Ser Glu Thr His Tyr 
65                  70                  75                  80  


Asn Gln Met Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ala Met Gly Tyr Trp Gly Gln Gly Thr Ser 
        115                 120                 125             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser 
145                 150                 155                 160 


Val Asn Ile Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser 
                165                 170                 175     


Leu Leu Asp Thr Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg 
            180                 185                 190         


Pro Gly Gln Ser Pro Asn Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp 
        195                 200                 205             


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
    210                 215                 220                 


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Tyr 
225                 230                 235                 240 


Cys Trp Gln Gly Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys 
                245                 250                 255     


Leu Glu Ile Lys Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
            260                 265                 270         


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
        275                 280                 285             


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
    290                 295                 300                 


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
305                 310                 315                 320 


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
                325                 330                 335     


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
            340                 345                 350         


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
        355                 360                 365             


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
    370                 375                 380                 


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
385                 390                 395                 400 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
                405                 410                 415     


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            420                 425                 430         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        435                 440                 445             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    450                 455                 460                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
465                 470                 475                 480 


Leu Pro Pro Arg 
                


<210>  38
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79B-15_LH CAR construct

<400>  38

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu 
            20                  25                  30          


Ser Val Asn Ile Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln 
        35                  40                  45              


Ser Leu Leu Asp Thr Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln 
    50                  55                  60                  


Arg Pro Gly Gln Ser Pro Asn Arg Leu Ile Tyr Leu Val Ser Lys Leu 
65                  70                  75                  80  


Asp Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr 
            100                 105                 110         


Tyr Cys Trp Gln Gly Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu 
145                 150                 155                 160 


Val Arg Pro Gln Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr 
                165                 170                 175     


Phe Thr Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly 
            180                 185                 190         


Leu Glu Trp Ile Gly Met Val Asp Pro Ser Asp Ser Glu Thr His Tyr 
        195                 200                 205             


Asn Gln Met Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
    210                 215                 220                 


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Arg Ala Met Gly Tyr Trp Gly Gln Gly Thr Ser 
                245                 250                 255     


Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
            260                 265                 270         


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
        275                 280                 285             


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
    290                 295                 300                 


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
305                 310                 315                 320 


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
                325                 330                 335     


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
            340                 345                 350         


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
        355                 360                 365             


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
    370                 375                 380                 


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
385                 390                 395                 400 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
                405                 410                 415     


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            420                 425                 430         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        435                 440                 445             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    450                 455                 460                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
465                 470                 475                 480 


Leu Pro Pro Arg 
                


<210>  39
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79B-17_HL CAR construct

<400>  39

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu 
            20                  25                  30          


Val Arg Pro Gln Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Met Val Asp Pro Ser Asp Ser Glu Thr His Tyr 
65                  70                  75                  80  


Asn Gln Met Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ala Met Gly Tyr Trp Gly Gln Gly Thr Ser 
        115                 120                 125             


Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser 
    130                 135                 140                 


Gly Glu Gly Ser Thr Lys Gly Asp Val Val Met Thr Gln Thr Pro Leu 
145                 150                 155                 160 


Thr Leu Ser Val Asn Ile Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser 
                165                 170                 175     


Ser Gln Ser Leu Leu Asp Thr Asp Gly Lys Thr Tyr Leu Asn Trp Leu 
            180                 185                 190         


Leu Gln Arg Pro Gly Gln Ser Pro Asn Arg Leu Ile Tyr Leu Val Ser 
        195                 200                 205             


Lys Leu Asp Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly 
225                 230                 235                 240 


Leu Tyr Tyr Cys Trp Gln Gly Thr His Phe Pro Leu Thr Phe Gly Ala 
                245                 250                 255     


Gly Thr Lys Leu Glu Ile Lys Arg Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  40
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79B-17_LH CAR construct

<400>  40

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu 
            20                  25                  30          


Ser Val Asn Ile Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln 
        35                  40                  45              


Ser Leu Leu Asp Thr Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln 
    50                  55                  60                  


Arg Pro Gly Gln Ser Pro Asn Arg Leu Ile Tyr Leu Val Ser Lys Leu 
65                  70                  75                  80  


Asp Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr 
            100                 105                 110         


Tyr Cys Trp Gln Gly Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
    130                 135                 140                 


Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Gln Pro Gly 
145                 150                 155                 160 


Ala Glu Leu Val Arg Pro Gln Ser Val Lys Leu Ser Cys Lys Ala Ser 
                165                 170                 175     


Gly Tyr Thr Phe Thr Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro 
            180                 185                 190         


Gly Gln Gly Leu Glu Trp Ile Gly Met Val Asp Pro Ser Asp Ser Glu 
        195                 200                 205             


Thr His Tyr Asn Gln Met Phe Lys Asp Lys Ala Thr Leu Thr Val Asp 
    210                 215                 220                 


Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu 
225                 230                 235                 240 


Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ala Met Gly Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  41
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79B-06_HL CAR polynucleotide construct

<400>  41
atggctctgc cagtgactgc acttctgctc ccgcttgcac tccttttgca tgccgcgaga       60

ccccaaatcc agctcgtcca aagtggaccc gaacttaaga agccaggaga gaccgtcaaa      120

atctcctgta aagctagtgg ttatacattc accgactact ccatgcactg ggttaaacag      180

gcccctgggg aaggtcttaa gtggatgggg tggatcaata ccgagaccgg ggaaccaaca      240

tacgctgacg atttcaaggg caggtttgca ttttctttgg agacctccgc atcaaccgcc      300

taccttcaga tcaacaacct gaagaatgag gacactgcca cgtatttttg ctactatggg      360

tcttactggg ggcaagggac actcgtgacg gtttctgcag ggggtggagg atccggcggc      420

ggtggttctg gaggaggagg gagcgatatt gtgttgaccc agagtcccgc ttcattggct      480

gtgagcctgg gtcaacgagc gaccatatcc tgcaaggcca gccagtctgt ggactatgat      540

ggtgatgggt acatggactg gtatcagcag aaaccgggac agcccccaaa actgttgatt      600

ttcgcagcga gcaaccttaa atccggcatc ccggcaaggt tctcaggttc aggctcaggt      660

actgacttta cattgaacat acaccccgtc gaggaggagg acgccgctac gtattactgc      720

cagcagacaa acgagtaccc ttggacattc ggcggtggca caaaattgga gataaagacc      780

acaacacctg ctccaaggcc ccccacaccc gctccaacta tagccagcca accattgagc      840

ctcagacctg aagcttgcag gcccgcagca ggaggcgccg tccatacgcg aggcctggac      900

ttcgcgtgtg atatttatat ttgggcccct ttggccggaa catgtggggt gttgcttctc      960

tcccttgtga tcactctgta ttgtaagcgc gggagaaaga agctcctgta catcttcaag     1020

cagcctttta tgcgacctgt gcaaaccact caggaagaag atgggtgttc atgccgcttc     1080

cccgaggagg aagaaggagg gtgtgaactg agggtgaaat tttctagaag cgccgatgct     1140

cccgcatatc agcagggtca gaatcagctc tacaatgaat tgaatctcgg caggcgagaa     1200

gagtacgatg ttctggacaa gagacggggc agggatcccg agatgggggg aaagccccgg     1260

agaaaaaatc ctcaggaggg gttgtacaat gagctgcaga aggacaagat ggctgaagcc     1320

tatagcgaga tcggaatgaa aggcgaaaga cgcagaggca aggggcatga cggtctgtac     1380

cagggtctct ctacagccac caaggacact tatgatgcgt tgcatatgca agccttgcca     1440

ccccgctaa                                                             1449


<210>  42
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79B-06_LH CAR polynucleotide construct

<400>  42
atggccctgc cagtcaccgc tttgttgctg cctctcgcac tgctgctgca cgctgcacgc       60

ccagacatcg tgctgacaca aagcccagct tcactggcag tgtctctcgg gcaacgggcg      120

acaataagct gcaaagcatc tcagagcgtc gattatgatg gagacggcta catggactgg      180

tatcagcaga aacccgggca gcccccaaag ctgctgattt tcgccgcgtc caatctgaag      240

tctggaattc cggcaagatt cagcgggtcc gggagtggaa ctgatttcac tctgaacatc      300

caccccgtgg aggaagagga tgccgccacc tactattgtc agcagacaaa cgagtacccc      360

tggacctttg ggggagggac aaagctggaa atcaaaggtg gaggggggag cggaggagga      420

ggtagcggag gaggcggaag tcagatacaa cttgttcaga gcggcccaga attgaagaag      480

ccgggggaga ccgtgaagat atcctgcaag gctagcgggt ataccttcac cgattatagc      540

atgcattggg ttaaacaggc ccccggtgaa ggtctgaagt ggatgggatg gattaacacc      600

gaaacaggag agcctacata tgccgacgac tttaagggac gcttcgcatt ctctctggaa      660

acctccgcaa gcactgcata cctgcaaatc aataacctga agaacgagga tacagccact      720

tatttttgct attacggatc atattggggt caggggaccc tggtaaccgt tagtgccacc      780

acaacacctg ctccaaggcc ccccacaccc gctccaacta tagccagcca accattgagc      840

ctcagacctg aagcttgcag gcccgcagca ggaggcgccg tccatacgcg aggcctggac      900

ttcgcgtgtg atatttatat ttgggcccct ttggccggaa catgtggggt gttgcttctc      960

tcccttgtga tcactctgta ttgtaagcgc gggagaaaga agctcctgta catcttcaag     1020

cagcctttta tgcgacctgt gcaaaccact caggaagaag atgggtgttc atgccgcttc     1080

cccgaggagg aagaaggagg gtgtgaactg agggtgaaat tttctagaag cgccgatgct     1140

cccgcatatc agcagggtca gaatcagctc tacaatgaat tgaatctcgg caggcgagaa     1200

gagtacgatg ttctggacaa gagacggggc agggatcccg agatgggggg aaagccccgg     1260

agaaaaaatc ctcaggaggg gttgtacaat gagctgcaga aggacaagat ggctgaagcc     1320

tatagcgaga tcggaatgaa aggcgaaaga cgcagaggca aggggcatga cggtctgtac     1380

cagggtctct ctacagccac caaggacact tatgatgcgt tgcatatgca agccttgcca     1440

ccccgctaa                                                             1449


<210>  43
<211>  1467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79B-08_HL CAR polynucleotide construct

<400>  43
atggcactgc ccgtgaccgc actgctgctt ccacttgccc tgctgttgca tgcagcgagg       60

cctgaagtgc agttggttga gagtggtgga ggccttgttc agcctggcgg ctctctgcgc      120

ttgagctgcg cagcatctgg ctatactttt agctcctact ggatcgagtg ggttagacag      180

gcccccggaa agggtctgga atggattggg gagattcttc caggaggcgg ggacaccaac      240

tacaacgaaa tctttaaggg tagagcaaca tttagcgcag acacgtccaa gaataccgcc      300

tacctgcaga tgaacagttt gcgcgcggaa gacacggctg tttattactg tactagacga      360

gtgcccataa gactcgacta ctggggtcaa ggaactctgg ttacagtgag ctccggagga      420

ggcggcagcg gtggtggggg atcaggtggc ggcgggtctg acatccagct cactcagtcc      480

ccaagtagcc tgagcgcttc cgttggcgac agggtcacga tcacgtgcaa ggcaagccag      540

tctgtcgatt atgaaggcga ctcctttctg aactggtatc aacagaaacc cggcaaagct      600

cctaagctgc tcatatatgc ggcctcaaat ctggaatccg gggtcccctc tcgatttagc      660

ggttctggat ctgggaccga cttcacactt acaatttcct ccctgcagcc tgaggacttt      720

gcaacatatt attgtcaaca gtccaacgag gaccccctta ccttcggtca aggcacaaaa      780

gttgagatca agaggaccac aacacctgct ccaaggcccc ccacacccgc tccaactata      840

gccagccaac cattgagcct cagacctgaa gcttgcaggc ccgcagcagg aggcgccgtc      900

catacgcgag gcctggactt cgcgtgtgat atttatattt gggccccttt ggccggaaca      960

tgtggggtgt tgcttctctc ccttgtgatc actctgtatt gtaagcgcgg gagaaagaag     1020

ctcctgtaca tcttcaagca gccttttatg cgacctgtgc aaaccactca ggaagaagat     1080

gggtgttcat gccgcttccc cgaggaggaa gaaggagggt gtgaactgag ggtgaaattt     1140

tctagaagcg ccgatgctcc cgcatatcag cagggtcaga atcagctcta caatgaattg     1200

aatctcggca ggcgagaaga gtacgatgtt ctggacaaga gacggggcag ggatcccgag     1260

atggggggaa agccccggag aaaaaatcct caggaggggt tgtacaatga gctgcagaag     1320

gacaagatgg ctgaagccta tagcgagatc ggaatgaaag gcgaaagacg cagaggcaag     1380

gggcatgacg gtctgtacca gggtctctct acagccacca aggacactta tgatgcgttg     1440

catatgcaag ccttgccacc ccgctaa                                         1467


<210>  44
<211>  1467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79B-08_LH CAR polynucleotide construct

<400>  44
atggcactcc ctgtgactgc cttgcttttg ccgcttgcat tgctgctcca tgcagccaga       60

ccagacattc agctcaccca gtccccatct tccctgagcg ccagcgtagg cgatcgcgtg      120

acgattacat gcaaagcctc acaatcagta gactatgagg gagatagctt cttgaactgg      180

tatcagcaga agcctgggaa agccccaaaa ctgcttattt acgccgcttc aaacctggaa      240

tcaggggtgc catctcggtt tagcggctcc gggtcaggca cagactttac tttgaccatc      300

tcttccctgc aaccagaaga tttcgccaca tattactgcc aacagtccaa tgaagatcca      360

ctgacattcg gacaggggac caaggtcgaa atcaagcgcg gcggtggtgg ctctggaggt      420

ggagggtccg gaggcggagg tagcgaggta cagctggttg agagcggtgg aggactggta      480

cagcccggag ggtcacttag actcagctgc gcagcttccg gctacacatt cagtagctac      540

tggatcgagt gggtgcggca ggcaccaggc aaagggctcg aatggatcgg ggagatcctt      600

cccggcgggg gcgacactaa ctataacgag atcttcaaag ggagggccac tttttccgcc      660

gacacctcaa agaatactgc ttatttgcag atgaactccc ttcgagctga agacactgcc      720

gtatattatt gcacccgcag agtgcccata cggctggact actggggaca gggcactctt      780

gtgaccgtat ctagcaccac aacacctgct ccaaggcccc ccacacccgc tccaactata      840

gccagccaac cattgagcct cagacctgaa gcttgcaggc ccgcagcagg aggcgccgtc      900

catacgcgag gcctggactt cgcgtgtgat atttatattt gggccccttt ggccggaaca      960

tgtggggtgt tgcttctctc ccttgtgatc actctgtatt gtaagcgcgg gagaaagaag     1020

ctcctgtaca tcttcaagca gccttttatg cgacctgtgc aaaccactca ggaagaagat     1080

gggtgttcat gccgcttccc cgaggaggaa gaaggagggt gtgaactgag ggtgaaattt     1140

tctagaagcg ccgatgctcc cgcatatcag cagggtcaga atcagctcta caatgaattg     1200

aatctcggca ggcgagaaga gtacgatgtt ctggacaaga gacggggcag ggatcccgag     1260

atggggggaa agccccggag aaaaaatcct caggaggggt tgtacaatga gctgcagaag     1320

gacaagatgg ctgaagccta tagcgagatc ggaatgaaag gcgaaagacg cagaggcaag     1380

gggcatgacg gtctgtacca gggtctctct acagccacca aggacactta tgatgcgttg     1440

catatgcaag ccttgccacc ccgctaa                                         1467


<210>  45
<211>  1455
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79B-15_HL CAR polynucleotide construct

<400>  45
atggctctgc ccgtcaccgc tcttctgctg ccccttgccc tcctgctgca cgccgccaga       60

ccccaggttc aactccaaca gcctggagcg gagctggtaa gaccacagtc tgtgaaactc      120

tcctgtaagg cttctgggta cacattcaca tcatactgga tgaactgggt taagcagcgc      180

ccagggcaag gcctggaatg gatagggatg gttgacccgt ccgattccga aacccattac      240

aaccaaatgt tcaaggataa ggccaccctg accgtggata aaagtagtag caccgcgtac      300

atgcaactta gctccctcac ttctgaagac agtgcagtgt actattgtgc gagggccatg      360

ggatactggg gtcagggaac atctgtgacc gtctcatcag gtggaggtgg atctggggga      420

gggggtagtg gcggcggggg aagcgatgta gttatgaccc agacgcccct cacactgagc      480

gtcaacattg ggcagccggc atccattagc tgcaagtcca gccagtctct gctggacaca      540

gacgggaaga cctacctcaa ttggctgctt cagagacccg gacagtcccc caacaggctg      600

atataccttg tttctaagct ggatagtggg gtcccagata ggttcaccgg cagcgggtct      660

gggaccgatt tcacgctcaa gattagtcgc gttgaggctg aggatcttgg cttgtactac      720

tgctggcagg gaacccactt tccacttacg tttggggcag ggacaaagtt ggagattaag      780

cgaaccacaa cacctgctcc aaggcccccc acacccgctc caactatagc cagccaacca      840

ttgagcctca gacctgaagc ttgcaggccc gcagcaggag gcgccgtcca tacgcgaggc      900

ctggacttcg cgtgtgatat ttatatttgg gcccctttgg ccggaacatg tggggtgttg      960

cttctctccc ttgtgatcac tctgtattgt aagcgcggga gaaagaagct cctgtacatc     1020

ttcaagcagc cttttatgcg acctgtgcaa accactcagg aagaagatgg gtgttcatgc     1080

cgcttccccg aggaggaaga aggagggtgt gaactgaggg tgaaattttc tagaagcgcc     1140

gatgctcccg catatcagca gggtcagaat cagctctaca atgaattgaa tctcggcagg     1200

cgagaagagt acgatgttct ggacaagaga cggggcaggg atcccgagat ggggggaaag     1260

ccccggagaa aaaatcctca ggaggggttg tacaatgagc tgcagaagga caagatggct     1320

gaagcctata gcgagatcgg aatgaaaggc gaaagacgca gaggcaaggg gcatgacggt     1380

ctgtaccagg gtctctctac agccaccaag gacacttatg atgcgttgca tatgcaagcc     1440

ttgccacccc gctaa                                                      1455


<210>  46
<211>  1455
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79B-15_LH CAR polynucleotide construct

<400>  46
atggcgctcc cggtcacagc attgctcctc cccttggctt tgcttctgca cgctgctcgc       60

ccagacgtgg taatgacgca gactcccctc acccttagtg tcaacattgg ccaaccagcg      120

tccatttctt gtaagagtag ccaatctttg ctcgacaccg atggaaagac ataccttaac      180

tggcttcttc agagacccgg gcagtctcca aatcgactga tttacctggt gagtaaactg      240

gattcaggcg tccccgatcg atttactggg tctgggtccg gaaccgattt cacactgaag      300

atcagtcgag tggaggctga agatctcggt ctgtactact gctggcaggg gacacatttc      360

ccccttacat tcggtgctgg aactaagctc gagatcaaga gggggggagg cggctccggt      420

ggcggtggca gcggcggagg gggcagtcaa gtgcaactcc aacagccggg agctgaactc      480

gtcagaccac agagtgtgaa actcagttgc aaggcaagcg gctacacatt cacatcctat      540

tggatgaatt gggtgaaaca gcggcctggt cagggtttgg agtggatagg catggtcgat      600

ccaagtgatt ccgagaccca ttacaatcag atgtttaagg ataaagccac tctgactgtg      660

gataaatctt cttccacagc ttatatgcag ctgtctagtc tgacctccga ggacagtgct      720

gtctactatt gcgcccgcgc gatgggatac tggggccagg gcactagcgt aacagtatca      780

agcaccacaa cacctgctcc aaggcccccc acacccgctc caactatagc cagccaacca      840

ttgagcctca gacctgaagc ttgcaggccc gcagcaggag gcgccgtcca tacgcgaggc      900

ctggacttcg cgtgtgatat ttatatttgg gcccctttgg ccggaacatg tggggtgttg      960

cttctctccc ttgtgatcac tctgtattgt aagcgcggga gaaagaagct cctgtacatc     1020

ttcaagcagc cttttatgcg acctgtgcaa accactcagg aagaagatgg gtgttcatgc     1080

cgcttccccg aggaggaaga aggagggtgt gaactgaggg tgaaattttc tagaagcgcc     1140

gatgctcccg catatcagca gggtcagaat cagctctaca atgaattgaa tctcggcagg     1200

cgagaagagt acgatgttct ggacaagaga cggggcaggg atcccgagat ggggggaaag     1260

ccccggagaa aaaatcctca ggaggggttg tacaatgagc tgcagaagga caagatggct     1320

gaagcctata gcgagatcgg aatgaaaggc gaaagacgca gaggcaaggg gcatgacggt     1380

ctgtaccagg gtctctctac agccaccaag gacacttatg atgcgttgca tatgcaagcc     1440

ttgccacccc gctaa                                                      1455


<210>  47
<211>  1464
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79B-17_HL CAR polynucleotide construct

<400>  47
atggcactcc cagtgacagc tctgctgctc ccactggcac tcctgctcca cgctgcccgg       60

ccgcaggttc aacttcagca gccaggcgcc gagttggtgc gcccccagtc cgtgaaactg      120

agctgtaaag cctcaggtta tacctttacg tcttattgga tgaattgggt aaaacagcgc      180

cccgggcaag gcctggaatg gattggtatg gtggatccgt cagactctga gacccattac      240

aaccagatgt tcaaggacaa ggcaacgctc acagtggata agtcatcaag cacagcctac      300

atgcagctgt ccagtctgac atccgaggat tctgctgtct attattgtgc aagggccatg      360

ggttactggg ggcaagggac ctccgtaacc gttagcagtg gctccacatc tggctccgga      420

aagcctggat caggtgaagg cagcacgaag ggggacgtag tgatgactca gacccccctg      480

actctcagcg ttaacatcgg gcagcccgca agcatcagtt gtaagtcaag tcaaagtttg      540

ttggatacgg acggcaaaac atatctcaac tggctgttgc agagaccagg acagtcacca      600

aacagactga tttatctggt ctccaaactt gactccgggg tccccgacag atttactggt      660

agcggctcag gaactgattt cacactcaag atctcccgcg tagaggccga ggatctgggg      720

ctttactact gctggcaggg cacccacttc ccacttacct tcggggccgg caccaagctc      780

gagatcaagc gcaccacaac acctgctcca aggcccccca cacccgctcc aactatagcc      840

agccaaccat tgagcctcag acctgaagct tgcaggcccg cagcaggagg cgccgtccat      900

acgcgaggcc tggacttcgc gtgtgatatt tatatttggg cccctttggc cggaacatgt      960

ggggtgttgc ttctctccct tgtgatcact ctgtattgta agcgcgggag aaagaagctc     1020

ctgtacatct tcaagcagcc ttttatgcga cctgtgcaaa ccactcagga agaagatggg     1080

tgttcatgcc gcttccccga ggaggaagaa ggagggtgtg aactgagggt gaaattttct     1140

agaagcgccg atgctcccgc atatcagcag ggtcagaatc agctctacaa tgaattgaat     1200

ctcggcaggc gagaagagta cgatgttctg gacaagagac ggggcaggga tcccgagatg     1260

gggggaaagc cccggagaaa aaatcctcag gaggggttgt acaatgagct gcagaaggac     1320

aagatggctg aagcctatag cgagatcgga atgaaaggcg aaagacgcag aggcaagggg     1380

catgacggtc tgtaccaggg tctctctaca gccaccaagg acacttatga tgcgttgcat     1440

atgcaagcct tgccaccccg ctaa                                            1464


<210>  48
<211>  1464
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD79B-17_LH CAR polynucleotide construct

<400>  48
atggctcttc ccgttaccgc attgttgctg cctctggccc tgttgcttca cgctgctcgc       60

ccagacgttg tgatgacaca gactcctctc accctgtccg ttaatattgg ccagcctgca      120

tcaatctctt gtaagagcag ccagtcactt ttggatacag atggtaagac atacctgaat      180

tggcttttgc aacggcctgg ccaatcccca aacaggttga tctacctcgt ttcaaagctg      240

gactccggcg tgcccgaccg ctttaccgga agtggatcag gaacggactt cactctgaag      300

atcagcagag tggaagctga ggatctcggt ctgtactact gctggcaggg aacgcatttc      360

ccattgacct tcggagcagg tacaaagctg gagatcaaga ggggctccac atctgggtct      420

ggcaaacccg gatccggcga gggatccact aaagggcagg tccagctgca gcagcccggc      480

gccgaactgg tgcgccccca gtccgtgaag ctcagttgca aagccagtgg gtataccttt      540

acgtcctact ggatgaattg ggtgaagcaa cgcccaggac aaggcctcga atggataggt      600

atggtcgatc cctctgattc agaaactcat tataaccaga tgtttaagga caaagccacc      660

cttacagtgg ataaatcaag ttctactgcc tacatgcagc tttcctcact gacatccgaa      720

gatagcgcgg tctactactg tgcgagggca atgggctact ggggccaggg cacaagtgtc      780

acagtttcca gtaccacaac acctgctcca aggcccccca cacccgctcc aactatagcc      840

agccaaccat tgagcctcag acctgaagct tgcaggcccg cagcaggagg cgccgtccat      900

acgcgaggcc tggacttcgc gtgtgatatt tatatttggg cccctttggc cggaacatgt      960

ggggtgttgc ttctctccct tgtgatcact ctgtattgta agcgcgggag aaagaagctc     1020

ctgtacatct tcaagcagcc ttttatgcga cctgtgcaaa ccactcagga agaagatggg     1080

tgttcatgcc gcttccccga ggaggaagaa ggagggtgtg aactgagggt gaaattttct     1140

agaagcgccg atgctcccgc atatcagcag ggtcagaatc agctctacaa tgaattgaat     1200

ctcggcaggc gagaagagta cgatgttctg gacaagagac ggggcaggga tcccgagatg     1260

gggggaaagc cccggagaaa aaatcctcag gaggggttgt acaatgagct gcagaaggac     1320

aagatggctg aagcctatag cgagatcgga atgaaaggcg aaagacgcag aggcaagggg     1380

catgacggtc tgtaccaggg tctctctaca gccaccaagg acacttatga tgcgttgcat     1440

atgcaagcct tgccaccccg ctaa                                            1464


<210>  49
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Ala Arg Leu Ala Leu Ser Pro Val Pro Ser His Trp Met Val Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ser Ala Glu Pro Val Pro Ala Ala Arg Ser Glu 
            20                  25                  30          


Asp Arg Tyr Arg Asn Pro Lys Gly Ser Ala Cys Ser Arg Ile Trp Gln 
        35                  40                  45              


Ser Pro Arg Phe Ile Ala Arg Lys Arg Gly Phe Thr Val Lys Met His 
    50                  55                  60                  


Cys Tyr Met Asn Ser Ala Ser Gly Asn Val Ser Trp Leu Trp Lys Gln 
65                  70                  75                  80  


Glu Met Asp Glu Asn Pro Gln Gln Leu Lys Leu Glu Lys Gly Arg Met 
                85                  90                  95      


Glu Glu Ser Gln Asn Glu Ser Leu Ala Thr Leu Thr Ile Gln Gly Ile 
            100                 105                 110         


Arg Phe Glu Asp Asn Gly Ile Tyr Phe Cys Gln Gln Lys Cys Asn Asn 
        115                 120                 125             


Thr Ser Glu Val Tyr Gln Gly Cys Gly Thr Glu Leu Arg Val Met Gly 
    130                 135                 140                 


Phe Ser Thr Leu Ala Gln Leu Lys Gln Arg Asn Thr Leu Lys Asp Gly 
145                 150                 155                 160 


Ile Ile Met Ile Gln Thr Leu Leu Ile Ile Leu Phe Ile Ile Val Pro 
                165                 170                 175     


Ile Phe Leu Leu Leu Asp Lys Asp Asp Ser Lys Ala Gly Met Glu Glu 
            180                 185                 190         


Asp His Thr Tyr Glu Gly Leu Asp Ile Asp Gln Thr Ala Thr Tyr Glu 
        195                 200                 205             


Asp Ile Val Thr Leu Arg Thr Gly Glu Val Lys Trp Ser Val Gly Glu 
    210                 215                 220                 


His Pro Gly Gln Glu 
225                 


<210>  50
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ala Arg Leu Ala Leu Ser Pro Val Pro Ser His Trp Met Val Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ser Ala Ala Glu Pro Val Pro Ala Ala Arg Ser 
            20                  25                  30          


Glu Asp Arg Tyr Arg Asn Pro Lys Gly Ser Ala Cys Ser Arg Ile Trp 
        35                  40                  45              


Gln Ser Pro Arg Phe Ile Ala Arg Lys Arg Gly Phe Thr Val Lys Met 
    50                  55                  60                  


His Cys Tyr Met Asn Ser Ala Ser Gly Asn Val Ser Trp Leu Trp Lys 
65                  70                  75                  80  


Gln Glu Met Asp Glu Asn Pro Gln Gln Leu Lys Leu Glu Lys Gly Arg 
                85                  90                  95      


Met Glu Glu Ser Gln Asn Glu Ser Leu Ala Thr Leu Thr Ile Gln Gly 
            100                 105                 110         


Ile Arg Phe Glu Asp Asn Gly Ile Tyr Phe Cys Gln Gln Lys Cys Asn 
        115                 120                 125             


Asn Thr Ser Glu Val Tyr Gln Gly Cys Gly Thr Glu Leu Arg Val Met 
    130                 135                 140                 


Gly Phe Ser Thr Leu Ala Gln Leu Lys Gln Arg Asn Thr Leu Lys Asp 
145                 150                 155                 160 


Gly Ile Ile Met Ile Gln Thr Leu Leu Ile Ile Leu Phe Ile Ile Val 
                165                 170                 175     


Pro Ile Phe Leu Leu Leu Asp Lys Asp Asp Ser Lys Ala Gly Met Glu 
            180                 185                 190         


Glu Asp His Thr Tyr Glu Gly Leu Asp Ile Asp Gln Thr Ala Thr Tyr 
        195                 200                 205             


Glu Asp Ile Val Thr Leu Arg Thr Gly Glu Val Lys Trp Ser Val Gly 
    210                 215                 220                 


Glu His Pro Gly Gln Glu 
225                 230 


<210>  51
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Ala Arg Leu Ala Leu Ser Pro Val Pro Ser His Trp Met Val Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ser Ala Ala Glu Pro Val Pro Ala Ala Arg Ser 
            20                  25                  30          


Glu Asp Arg Tyr Arg Asn Pro Lys Gly Phe Ser Thr Leu Ala Gln Leu 
        35                  40                  45              


Lys Gln Arg Asn Thr Leu Lys Asp Gly Ile Ile Met Ile Gln Thr Leu 
    50                  55                  60                  


Leu Ile Ile Leu Phe Ile Ile Val Pro Ile Phe Leu Leu Leu Asp Lys 
65                  70                  75                  80  


Asp Asp Ser Lys Ala Gly Met Glu Glu Asp His Thr Tyr Glu Gly Leu 
                85                  90                  95      


Asp Ile Asp Gln Thr Ala Thr Tyr Glu Asp Ile Val Thr Leu Arg Thr 
            100                 105                 110         


Gly Glu Val Lys Trp Ser Val Gly Glu His Pro Gly Gln Glu 
        115                 120                 125     


<210>  52
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ala Arg Leu Ala Leu Ser Pro Val Pro Ser His Trp Met Val Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ser Ala Glu Pro Val Pro Ala Ala Arg Ser Glu 
            20                  25                  30          


Asp Arg Tyr Arg Asn Pro Lys Gly Phe Ser Thr Leu Ala Gln Leu Lys 
        35                  40                  45              


Gln Arg Asn Thr Leu Lys Asp Gly Ile Ile Met Ile Gln Thr Leu Leu 
    50                  55                  60                  


Ile Ile Leu Phe Ile Ile Val Pro Ile Phe Leu Leu Leu Asp Lys Asp 
65                  70                  75                  80  


Asp Ser Lys Ala Gly Met Glu Glu Asp His Thr Tyr Glu Gly Leu Asp 
                85                  90                  95      


Ile Asp Gln Thr Ala Thr Tyr Glu Asp Ile Val Thr Leu Arg Thr Gly 
            100                 105                 110         


Glu Val Lys Trp Ser Val Gly Glu His Pro Gly Gln Glu 
        115                 120                 125 


<210>  53
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  53

Asp Gly Gly Gly Ser 
1               5   


<210>  54
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  54

Thr Gly Glu Lys Pro 
1               5   


<210>  55
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  55

Gly Gly Arg Arg 
1               


<210>  56
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  56

Gly Gly Gly Gly Ser 
1               5   


<210>  57
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  57

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Val Asp 
1               5                   10                  


<210>  58
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  58

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  59
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  59

Gly Gly Arg Arg Gly Gly Gly Ser 
1               5               


<210>  60
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  60

Leu Arg Gln Arg Asp Gly Glu Arg Pro 
1               5                   


<210>  61
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  61

Leu Arg Gln Lys Asp Gly Gly Gly Ser Glu Arg Pro 
1               5                   10          


<210>  62
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  62

Leu Arg Gln Lys Asp Gly Gly Gly Ser Gly Gly Gly Ser Glu Arg Pro 
1               5                   10                  15      


<210>  63
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  63

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  64
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage sequence by TEV protease


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa is any amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = Gly or Ser

<400>  64

Glu Xaa Xaa Tyr Xaa Gln Xaa 
1               5           


<210>  65
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage sequence by TEV protease

<400>  65

Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210>  66
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage sequence by TEV protease

<400>  66

Glu Asn Leu Tyr Phe Gln Ser 
1               5           


<210>  67
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  67

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  68
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  68

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  69
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  69

Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
1               5                   10                  


<210>  70
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  70

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  71
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  71

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  72
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  72

Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
1               5                   10              


<210>  73
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  73

Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210>  74
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  74

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  75
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  75

Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
1               5                   10                  


<210>  76
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  76

Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
1               5                   10                  15      


Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25  


<210>  77
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  77

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  78
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  78

Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
1               5                   10                  


<210>  79
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  79

Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  80
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  80

Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  81
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  81

Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
1               5                   10                  


<210>  82
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  82

Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
1               5                   10                  15      


Pro 
    


<210>  83
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  83

Gln Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  84
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  84

Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
1               5                   10                  15      


Asp Val Glu Ser Asn Pro Gly Pro 
            20                  


<210>  85
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  85

Val Thr Glu Leu Leu Tyr Arg Met Lys Arg Ala Glu Thr Tyr Cys Pro 
1               5                   10                  15      


Arg Pro Leu Leu Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys 
            20                  25                  30          


Ile Val Ala Pro Val Lys Gln Thr 
        35                  40  


<210>  86
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  86

Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  87
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  87

Leu Leu Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys Ile Val 
1               5                   10                  15      


Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
            20                  25                  30          


Asp Val Glu Ser Asn Pro Gly Pro 
        35                  40  


<210>  88
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  88

Glu Ala Arg His Lys Gln Lys Ile Val Ala Pro Val Lys Gln Thr Leu 
1               5                   10                  15      


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
            20                  25                  30          


Pro 
    


<210>  89
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Consensus Kozak sequence

<400>  89
gccrccatgg                                                              10


<210>  90
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary rule for determining light chain CDR-L3 motif


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<400>  90

Phe Gly Xaa Gly 
1               


<210>  91
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary rule for determining heavy chain CDR-H1motif


<220>
<221>  MISC_FEATURE
<222>  (2)..(4)
<223>  Xaa is any amino acid

<400>  91

Cys Xaa Xaa Xaa 
1               


<210>  92
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary rule for determining heavy chain CDR-H2motif

<400>  92

Leu Glu Trp Ile Gly 
1               5   


<210>  93
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary rule for determining heavy chain CDR-H3 motif


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<400>  93

Trp Gly Xaa Gly 
1               


