                         SEQUENCE LISTING

<110>  dela Cruz, Jay
 
<120>  TREATMENT OF SYNUCLEINOPATHY AND ANIMAL MODELS OF SYNUCLEINOPATHY

<130>  ITBS-01-PCT

<140>  PCT/US19/37385
<141>  2019-06-14

<150>  US 62/685,868
<151>  2018-06-15

<150>  US 62/685,985
<151>  2018-06-16

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  584
<212>  DNA
<213>  Homo sapiens

<400>  1
gcctcctggg atggatgtca cccgcttact cctggccacc ctgctggtct tcctctgctt       60

cttcactgcc aacagccacc tgccacctga ggagaagctc cgagatgaca ggagcctgag      120

aagcaactcc tctgtgaacc tactggatgt cccttctgtc tctattgtgg cgctgaacaa      180

gaaatccaaa cagatcggca gaaaagcagc agaaaagaaa agatcttcta agaaggaggc      240

ttcgatgaag aaagtggtgc ggccccggac ccccctatct gcgccctgcg tggccacccg      300

caacagctgc aagccgccgg cacccgcctg ctgcgacccg tgcgcctcct gccagtgccg      360

cttcttccgc agcgcctgct cctgccgcgt gctcagcctc aactgctgag cgcccccact      420

cccggccgcg agcaggcagg gcttcgggga cgcggggcgc ttctcgggcg ggtgatccct      480

aacagggcgg cttcccaggg ctgcaggcgg gcggaggttc caggagatgg gacttcaggg      540

agacctggct tgggctaaaa tcgaaataca atatatatag gctg                       584


<210>  2
<211>  396
<212>  DNA
<213>  Homo sapiens

<400>  2
tggatgtcac ccgcttactc ctggccaccc tgctggtctt cctctgcttc ttcactgcca       60

acagccacct gccacctgag gagaagctcc gagatgacag gagcctgaga agcaactcct      120

ctgtgaacct actggatgtc ccttctgtct ctattgtggc gctgaacaag aaatccaaac      180

agatcggcag aaaagcagca gaaaagaaaa gatcttctaa gaaggaggct tcgatgaaga      240

aagtggtgcg gccccggacc cccctatctg cgccctgcgt ggccacccgc aacagctgca      300

agccgccggc acccgcctgc tgcgacccgt gcgcctcctg ccagtgccgc ttcttccgca      360

gcgcctgctc ctgccgcgtg ctcagcctca actgct                                396


<210>  3
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asp Val Thr Arg Leu Leu Leu Ala Thr Leu Leu Val Phe Leu Cys 
1               5                   10                  15      


Phe Phe Thr Ala Asn Ser His Leu Pro Pro Glu Glu Lys Leu Arg Asp 
            20                  25                  30          


Asp Arg Ser Leu Arg Ser Asn Ser Ser Val Asn Leu Leu Asp Val Pro 
        35                  40                  45              


Ser Val Ser Ile Val Ala Leu Asn Lys Lys Ser Lys Gln Ile Gly Arg 
    50                  55                  60                  


Lys Ala Ala Glu Lys Lys Arg Ser Ser Lys Lys Glu Ala Ser Met Lys 
65                  70                  75                  80  


Lys Val Val Arg Pro Arg Thr Pro Leu Ser Ala Pro Cys Val Ala Thr 
                85                  90                  95      


Arg Asn Ser Cys Lys Pro Pro Ala Pro Ala Cys Cys Asp Pro Cys Ala 
            100                 105                 110         


Ser Cys Gln Cys Arg Phe Phe Arg Ser Ala Cys Ser Cys Arg Val Leu 
        115                 120                 125             


Ser Leu Asn Cys 
    130         


<210>  4
<211>  783
<212>  DNA
<213>  Homo sapiens

<400>  4
agctcctagg tccctgtcct gtggaaattt gtggaccctg ggcaccctct cttgctccca       60

aattttaatc ggctcctgga aacctcaccc caaattggag ataggcactc ctcttgtaga      120

acaaaaggct caggttcagg gagtgagggc ctgaactgtg cccccaccct ccaggaaggg      180

tccttcacgg cctggctgca gggatcagtc acgtgtggcc cttcattagg ccctgccata      240

taagccaagg gcacggggtg gccgggaact ctctaggcaa gaatcccgga ggcagaggcc      300

atgctgaccg cagcggtgct gagctgtgcc ctgctgctgg cactgcctgc cacgcgagga      360

gcccagatgg gcttggcccc catggagggc atcagaaggc ctgaccaggc cctgctccca      420

gagctcccag gcctgggcct gcgggcccca ctgaagaaga caactgcaga acaggcagaa      480

gaggatctgt tgcaggaggc tcaggccttg gcagaggtac tagacctgca ggaccgcgag      540

ccccgctcct cacgtcgctg cgtaaggctg catgagtcct gcctgggaca gcaggtgcct      600

tgctgtgacc catgtgccac gtgctactgc cgcttcttca atgccttctg ctactgccgc      660

aagctgggta ctgccatgaa tccctgcagc cgcacctagc tggccaacgt cagggtcggg      720

gctagggtag gggcaaggaa actcgaataa aggatgggac caacaaaaaa aaaaaaaaaa      780

aaa                                                                    783


<210>  5
<211>  396
<212>  DNA
<213>  Homo sapiens

<400>  5
tgctgaccgc agcggtgctg agctgtgccc tgctgctggc actgcctgcc acgcgaggag       60

cccagatggg cttggccccc atggagggca tcagaaggcc tgaccaggcc ctgctcccag      120

agctcccagg cctgggcctg cgggccccac tgaagaagac aactgcagaa caggcagaag      180

aggatctgtt gcaggaggct caggccttgg cagaggtact agacctgcag gaccgcgagc      240

cccgctcctc acgtcgctgc gtaaggctgc atgagtcctg cctgggacag caggtgcctt      300

gctgtgaccc atgtgccacg tgctactgcc gcttcttcaa tgccttctgc tactgccgca      360

agctgggtac tgccatgaat ccctgcagcc gcacct                                396


<210>  6
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Leu Thr Ala Ala Val Leu Ser Cys Ala Leu Leu Leu Ala Leu Pro 
1               5                   10                  15      


Ala Thr Arg Gly Ala Gln Met Gly Leu Ala Pro Met Glu Gly Ile Arg 
            20                  25                  30          


Arg Pro Asp Gln Ala Leu Leu Pro Glu Leu Pro Gly Leu Gly Leu Arg 
        35                  40                  45              


Ala Pro Leu Lys Lys Thr Thr Ala Glu Gln Ala Glu Glu Asp Leu Leu 
    50                  55                  60                  


Gln Glu Ala Gln Ala Leu Ala Glu Val Leu Asp Leu Gln Asp Arg Glu 
65                  70                  75                  80  


Pro Arg Ser Ser Arg Arg Cys Val Arg Leu His Glu Ser Cys Leu Gly 
                85                  90                  95      


Gln Gln Val Pro Cys Cys Asp Pro Cys Ala Thr Cys Tyr Cys Arg Phe 
            100                 105                 110         


Phe Asn Ala Phe Cys Tyr Cys Arg Lys Leu Gly Thr Ala Met Asn Pro 
        115                 120                 125             


Cys Ser Arg Thr 
    130         


<210>  7
<211>  518
<212>  DNA
<213>  Homo sapiens

<400>  7
caaatccata gggagctctg ccttaccatt gggttcctaa ttaactgagt gagtgggtgt       60

gttctgcatg gtgagaggca ttggaatgat gcatcagaaa acatgtcata atgtcatcac      120

tgtaatatga caagaattgc agctgtggct ggaaccttta taaagtgacc aagcacacct      180

tttcatccag tctcagcgtg gggtgaagcc tagcagctat gaggatccat tatcttctgt      240

ttgctttgct cttcctgttt ttggtgcctg ttccaggtca tggaggaatc ataaacacat      300

tacagaaata ttattgcaga gtcagaggcg gccggtgtgc tgtgctcagc tgccttccaa      360

aggaggaaca gatcggcaag tgctcgacgc gtggccgaaa atgctgccga agaaagaaat      420

aaaaaccctg aaacatgacg agagtgttgt aaagtgtgga aatgccttct taaagtttat      480

aaaagtaaaa tcaaattaca tttttttttc aaaaaaaa                              518


<210>  8
<211>  201
<212>  DNA
<213>  Homo sapiens

<400>  8
tgaggatcca ttatcttctg tttgctttgc tcttcctgtt tttggtgcct gttccaggtc       60

atggaggaat cataaacaca ttacagaaat attattgcag agtcagaggc ggccggtgtg      120

ctgtgctcag ctgccttcca aaggaggaac agatcggcaa gtgctcgacg cgtggccgaa      180

aatgctgccg aagaaagaaa t                                                201


<210>  9
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Arg Ile His Tyr Leu Leu Phe Ala Leu Leu Phe Leu Phe Leu Val 
1               5                   10                  15      


Pro Val Pro Gly His Gly Gly Ile Ile Asn Thr Leu Gln Lys Tyr Tyr 
            20                  25                  30          


Cys Arg Val Arg Gly Gly Arg Cys Ala Val Leu Ser Cys Leu Pro Lys 
        35                  40                  45              


Glu Glu Gln Ile Gly Lys Cys Ser Thr Arg Gly Arg Lys Cys Cys Arg 
    50                  55                  60                  


Arg Lys Lys 
65          


<210>  10
<211>  1406
<212>  DNA
<213>  Homo sapiens

<400>  10
gttctaagcg gagacccaac gccatccata attaagttct tcctgagggc gagcggccag       60

gtgcgccttc ggcaggacag tgctaattcc agcccctttc cagcgcgtct ccccgcgctc      120

gtcccccgtc tggaagcccc cctcccacgc cccgcggccc cccttcccct ggcccgggga      180

gctgctcctt gtgctgccgg gaaggtcaaa gtcccgcgcc caccaggaga gctcggcaag      240

tatataagga cagaggagcg cgggaccaag cggcggcgaa ggaggggaag aagagccgcg      300

accgagagag gccgccgagc gtccccgccc tcagagagca gcctcccgag acagagcctc      360

agcctgcctg gaagatgccg agatcgtgct gcagccgctc gggggccctg ttgctggcct      420

tgctgcttca ggcctccatg gaagtgcgtg gctggtgcct ggagagcagc cagtgtcagg      480

acctcaccac ggaaagcaac ctgctggagt gcatccgggc ctgcaagccc gacctctcgg      540

ccgagactcc catgttcccg ggaaatggcg acgagcagcc tctgaccgag aacccccgga      600

agtacgtcat gggccacttc cgctgggacc gattcggccg ccgcaacagc agcagcagcg      660

gcagcagcgg cgcagggcag aagcgcgagg acgtctcagc gggcgaagac tgcggcccgc      720

tgcctgaggg cggccccgag ccccgcagcg atggtgccaa gccgggcccg cgcgagggca      780

agcgctccta ctccatggag cacttccgct ggggcaagcc ggtgggcaag aagcggcgcc      840

cagtgaaggt gtaccctaac ggcgccgagg acgagtcggc cgaggccttc cccctggagt      900

tcaagaggga gctgactggc cagcgactcc gggagggaga tggccccgac ggccctgccg      960

atgacggcgc aggggcccag gccgacctgg agcacagcct gctggtggcg gccgagaaga     1020

aggacgaggg cccctacagg atggagcact tccgctgggg cagcccgccc aaggacaagc     1080

gctacggcgg tttcatgacc tccgagaaga gccagacgcc cctggtgacg ctgttcaaaa     1140

acgccatcat caagaacgcc tacaagaagg gcgagtgagg gcacagcggg gccccagggc     1200

taccctcccc caggaggtcg accccaaagc cccttgctct cccctgccct gctgccgcct     1260

cccagcctgg ggggtcgtgg cagataatca gcctcttaaa gctgcctgta gttaggaaat     1320

aaaacctttc aaatttcaca tccacctctg actttgaatg taaactgtgt gaataaagta     1380

aaaatacgta gccgtcaaat aacagc                                          1406


<210>  11
<211>  40
<212>  DNA
<213>  Homo sapiens

<400>  11
tcctactcca tggagcactt ccgctggggc aagccggtgg                             40


<210>  12
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  12

Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val 
1               5                   10              


<210>  13
<211>  1406
<212>  DNA
<213>  Homo sapiens

<400>  13
gttctaagcg gagacccaac gccatccata attaagttct tcctgagggc gagcggccag       60

gtgcgccttc ggcaggacag tgctaattcc agcccctttc cagcgcgtct ccccgcgctc      120

gtcccccgtc tggaagcccc cctcccacgc cccgcggccc cccttcccct ggcccgggga      180

gctgctcctt gtgctgccgg gaaggtcaaa gtcccgcgcc caccaggaga gctcggcaag      240

tatataagga cagaggagcg cgggaccaag cggcggcgaa ggaggggaag aagagccgcg      300

accgagagag gccgccgagc gtccccgccc tcagagagca gcctcccgag acagagcctc      360

agcctgcctg gaagatgccg agatcgtgct gcagccgctc gggggccctg ttgctggcct      420

tgctgcttca ggcctccatg gaagtgcgtg gctggtgcct ggagagcagc cagtgtcagg      480

acctcaccac ggaaagcaac ctgctggagt gcatccgggc ctgcaagccc gacctctcgg      540

ccgagactcc catgttcccg ggaaatggcg acgagcagcc tctgaccgag aacccccgga      600

agtacgtcat gggccacttc cgctgggacc gattcggccg ccgcaacagc agcagcagcg      660

gcagcagcgg cgcagggcag aagcgcgagg acgtctcagc gggcgaagac tgcggcccgc      720

tgcctgaggg cggccccgag ccccgcagcg atggtgccaa gccgggcccg cgcgagggca      780

agcgctccta ctccatggag cacttccgct ggggcaagcc ggtgggcaag aagcggcgcc      840

cagtgaaggt gtaccctaac ggcgccgagg acgagtcggc cgaggccttc cccctggagt      900

tcaagaggga gctgactggc cagcgactcc gggagggaga tggccccgac ggccctgccg      960

atgacggcgc aggggcccag gccgacctgg agcacagcct gctggtggcg gccgagaaga     1020

aggacgaggg cccctacagg atggagcact tccgctgggg cagcccgccc aaggacaagc     1080

gctacggcgg tttcatgacc tccgagaaga gccagacgcc cctggtgacg ctgttcaaaa     1140

acgccatcat caagaacgcc tacaagaagg gcgagtgagg gcacagcggg gccccagggc     1200

taccctcccc caggaggtcg accccaaagc cccttgctct cccctgccct gctgccgcct     1260

cccagcctgg ggggtcgtgg cagataatca gcctcttaaa gctgcctgta gttaggaaat     1320

aaaacctttc aaatttcaca tccacctctg actttgaatg taaactgtgt gaataaagta     1380

aaaatacgta gccgtcaaat aacagc                                          1406


<210>  14
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  14
acgagggccc ctacaggatg gagcacttcc gctggggcag cccgcccaag gaca             54


<210>  15
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  15

Asp Glu Gly Pro Tyr Arg Met Glu His Phe Arg Trp Gly Ser Pro Pro 
1               5                   10                  15      


Lys Asp 
        


