                         SEQUENCE LISTING

<110>  Alpine Immune Sciences, Inc.
       SWANSON, Ryan
       DEMONTE, Daniel William
 
<120>  PD-1 VARIANT IMMUNOMODULATORY PROTEINS AND USES THEREOF

<130>  761612002440

<140> Not Yet Assigned    
<141> Concurrently Herewith  

<150>  62/685,880
<151>  2018-06-15

<150>  62/753,886
<151>  2018-10-31

<150>  62/774,145
<151>  2018-11-30

<160>  1104  

<170>  PatentIn version 3.5

<210>  1
<211>  288
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD80(B7-1)

<400>  1

Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu 
        35                  40                  45              


Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile 
    50                  55                  60                  


Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp 
65                  70                  75                  80  


Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr 
                85                  90                  95      


Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly 
            100                 105                 110         


Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
        115                 120                 125             


Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr 
    130                 135                 140                 


Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile 
145                 150                 155                 160 


Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu 
                165                 170                 175     


Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp 
            180                 185                 190         


Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met 
        195                 200                 205             


Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg 
    210                 215                 220                 


Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro 
225                 230                 235                 240 


Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly 
                245                 250                 255     


Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg 
            260                 265                 270         


Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val 
        275                 280                 285             


<210>  2
<211>  329
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD86(B7-2)

<400>  2

Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val Met 
1               5                   10                  15      


Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe 
            20                  25                  30          


Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln 
        35                  40                  45              


Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln Glu Asn Leu Val 
    50                  55                  60                  


Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe Asp Ser Val His Ser 
65                  70                  75                  80  


Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg 
                85                  90                  95      


Leu His Asn Leu Gln Ile Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile 
            100                 105                 110         


His His Lys Lys Pro Thr Gly Met Ile Arg Ile His Gln Met Asn Ser 
        115                 120                 125             


Glu Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Val Pro Ile 
    130                 135                 140                 


Ser Asn Ile Thr Glu Asn Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile 
145                 150                 155                 160 


His Gly Tyr Pro Glu Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys 
                165                 170                 175     


Asn Ser Thr Ile Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn 
            180                 185                 190         


Val Thr Glu Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro 
        195                 200                 205             


Asp Val Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys 
    210                 215                 220                 


Thr Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
225                 230                 235                 240 


Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr Val 
                245                 250                 255     


Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys 
            260                 265                 270         


Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn Thr Met Glu 
        275                 280                 285             


Arg Glu Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys Ile His Ile Pro 
    290                 295                 300                 


Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys Ser Ser Lys Thr Ser 
305                 310                 315                 320 


Ser Cys Asp Lys Ser Asp Thr Cys Phe 
                325                 


<210>  3
<211>  290
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD274 (PD-L1, B7-H1)

<400>  3

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  4
<211>  273
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  PDCD1LG2(PD-L2, CD273)

<400>  4

Met Ile Phe Leu Leu Leu Met Leu Ser Leu Glu Leu Gln Leu His Gln 
1               5                   10                  15      


Ile Ala Ala Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile 
            20                  25                  30          


Glu His Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser 
        35                  40                  45              


His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp 
                85                  90                  95      


Glu Gly Gln Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr 
            100                 105                 110         


Lys Tyr Leu Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr 
        115                 120                 125             


His Ile Leu Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln 
    130                 135                 140                 


Ala Thr Gly Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys 
            180                 185                 190         


Val Phe Trp Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp 
        195                 200                 205             


Leu Gln Ser Gln Met Glu Pro Arg Thr His Pro Thr Trp Leu Leu His 
    210                 215                 220                 


Ile Phe Ile Pro Phe Cys Ile Ile Ala Phe Ile Phe Ile Ala Thr Val 
225                 230                 235                 240 


Ile Ala Leu Arg Lys Gln Leu Cys Gln Lys Leu Tyr Ser Ser Lys Asp 
                245                 250                 255     


Thr Thr Lys Arg Pro Val Thr Thr Thr Lys Arg Glu Val Asn Ser Ala 
            260                 265                 270         


Ile 
    


<210>  5
<211>  302
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  ICOSLG(B7RP1, CD275, ICOSL, B7-H2)

<400>  5

Met Arg Leu Gly Ser Pro Gly Leu Leu Phe Leu Leu Phe Ser Ser Leu 
1               5                   10                  15      


Arg Ala Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp 
            20                  25                  30          


Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn 
        35                  40                  45              


Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr 
    50                  55                  60                  


Tyr His Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr 
65                  70                  75                  80  


Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe 
                85                  90                  95      


Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His 
            100                 105                 110         


Cys Leu Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val 
        115                 120                 125             


Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser 
    130                 135                 140                 


Ala Pro His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser 
145                 150                 155                 160 


Ile Asn Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp 
                165                 170                 175     


Asn Ser Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn 
            180                 185                 190         


Met Arg Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr 
        195                 200                 205             


Pro Ser Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln 
    210                 215                 220                 


Asn Leu Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp 
225                 230                 235                 240 


Lys Ile Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
                245                 250                 255     


Trp Ser Ile Leu Ala Val Leu Cys Leu Leu Val Val Val Ala Val Ala 
            260                 265                 270         


Ile Gly Trp Val Cys Arg Asp Arg Cys Leu Gln His Ser Tyr Ala Gly 
        275                 280                 285             


Ala Trp Ala Val Ser Pro Glu Thr Glu Leu Thr Gly His Val 
    290                 295                 300         


<210>  6
<211>  534
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD276(B7-H3)

<400>  6

Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala 
1               5                   10                  15      


Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln 
            20                  25                  30          


Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu 
        35                  40                  45              


Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn 
    50                  55                  60                  


Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala 
65                  70                  75                  80  


Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe 
                85                  90                  95      


Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val 
            100                 105                 110         


Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp 
        115                 120                 125             


Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys 
    130                 135                 140                 


Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr 
145                 150                 155                 160 


Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro Glu Ala Glu Val 
                165                 170                 175     


Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr 
            180                 185                 190         


Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Ile Leu 
        195                 200                 205             


Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn 
    210                 215                 220                 


Pro Val Leu Gln Gln Asp Ala His Ser Ser Val Thr Ile Thr Pro Gln 
225                 230                 235                 240 


Arg Ser Pro Thr Gly Ala Val Glu Val Gln Val Pro Glu Asp Pro Val 
                245                 250                 255     


Val Ala Leu Val Gly Thr Asp Ala Thr Leu Arg Cys Ser Phe Ser Pro 
            260                 265                 270         


Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr 
        275                 280                 285             


Asp Thr Lys Gln Leu Val His Ser Phe Thr Glu Gly Arg Asp Gln Gly 
    290                 295                 300                 


Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln 
305                 310                 315                 320 


Gly Asn Ala Ser Leu Arg Leu Gln Arg Val Arg Val Ala Asp Glu Gly 
                325                 330                 335     


Ser Phe Thr Cys Phe Val Ser Ile Arg Asp Phe Gly Ser Ala Ala Val 
            340                 345                 350         


Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu 
        355                 360                 365             


Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr Ile Thr Cys Ser 
    370                 375                 380                 


Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val Phe Trp Gln Asp Gly Gln 
385                 390                 395                 400 


Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln Met Ala Asn Glu 
                405                 410                 415     


Gln Gly Leu Phe Asp Val His Ser Val Leu Arg Val Val Leu Gly Ala 
            420                 425                 430         


Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val Leu Gln Gln Asp 
        435                 440                 445             


Ala His Gly Ser Val Thr Ile Thr Gly Gln Pro Met Thr Phe Pro Pro 
    450                 455                 460                 


Glu Ala Leu Trp Val Thr Val Gly Leu Ser Val Cys Leu Ile Ala Leu 
465                 470                 475                 480 


Leu Val Ala Leu Ala Phe Val Cys Trp Arg Lys Ile Lys Gln Ser Cys 
                485                 490                 495     


Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln Asp Gly Glu Gly Glu Gly 
            500                 505                 510         


Ser Lys Thr Ala Leu Gln Pro Leu Lys His Ser Asp Ser Lys Glu Asp 
        515                 520                 525             


Asp Gly Gln Glu Ile Ala 
    530                 


<210>  7
<211>  282
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  VTCN1(B7-H4)

<400>  7

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser 
                245                 250                 255     


Lys Ala Ser Leu Cys Val Ser Ser Phe Phe Ala Ile Ser Trp Ala Leu 
            260                 265                 270         


Leu Pro Leu Ser Pro Tyr Leu Met Leu Lys 
        275                 280         


<210>  8
<211>  220
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD28

<400>  8

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210>  9
<211>  223
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CTLA4

<400>  9

Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
65                  70                  75                  80  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
                85                  90                  95      


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 


Asp Phe Leu Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe 
                165                 170                 175     


Tyr Ser Phe Leu Leu Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys 
            180                 185                 190         


Arg Ser Pro Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu 
        195                 200                 205             


Pro Glu Cys Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
    210                 215                 220             


<210>  10
<211>  288
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  PDCD1(PD-1)

<400>  10

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  11
<211>  199
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  ICOS

<400>  11

Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Cys Leu Arg Ile Lys 
1               5                   10                  15      


Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val 
        35                  40                  45              


Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu 
65                  70                  75                  80  


Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu 
        115                 120                 125             


His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro 
    130                 135                 140                 


Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu 
145                 150                 155                 160 


Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro 
                165                 170                 175     


Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser 
            180                 185                 190         


Arg Leu Thr Asp Val Thr Leu 
        195                 


<210>  12
<211>  289
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  BTLA(CD272)

<400>  12

Met Lys Thr Leu Pro Ala Met Leu Gly Thr Gly Lys Leu Phe Trp Val 
1               5                   10                  15      


Phe Phe Leu Ile Pro Tyr Leu Asp Ile Trp Asn Ile His Gly Lys Glu 
            20                  25                  30          


Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Glu His Ser Ile 
        35                  40                  45              


Leu Ala Gly Asp Pro Phe Glu Leu Glu Cys Pro Val Lys Tyr Cys Ala 
    50                  55                  60                  


Asn Arg Pro His Val Thr Trp Cys Lys Leu Asn Gly Thr Thr Cys Val 
65                  70                  75                  80  


Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys Glu Glu Lys Asn Ile Ser 
                85                  90                  95      


Phe Phe Ile Leu His Phe Glu Pro Val Leu Pro Asn Asp Asn Gly Ser 
            100                 105                 110         


Tyr Arg Cys Ser Ala Asn Phe Gln Ser Asn Leu Ile Glu Ser His Ser 
        115                 120                 125             


Thr Thr Leu Tyr Val Thr Asp Val Lys Ser Ala Ser Glu Arg Pro Ser 
    130                 135                 140                 


Lys Asp Glu Met Ala Ser Arg Pro Trp Leu Leu Tyr Arg Leu Leu Pro 
145                 150                 155                 160 


Leu Gly Gly Leu Pro Leu Leu Ile Thr Thr Cys Phe Cys Leu Phe Cys 
                165                 170                 175     


Cys Leu Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser Asp Thr Ala 
            180                 185                 190         


Gly Arg Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu Gln Thr 
        195                 200                 205             


Glu Ala Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu Thr Gly 
    210                 215                 220                 


Ile Tyr Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu Gly Ser 
225                 230                 235                 240 


Glu Val Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly Ile Val 
                245                 250                 255     


Tyr Ala Ser Leu Asn His Ser Val Ile Gly Pro Asn Ser Arg Leu Ala 
            260                 265                 270         


Arg Asn Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val Arg 
        275                 280                 285             


Ser 
    


<210>  13
<211>  458
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD4

<400>  13

Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu 
1               5                   10                  15      


Ala Leu Leu Pro Ala Ala Thr Gln Gly Lys Lys Val Val Leu Gly Lys 
            20                  25                  30          


Lys Gly Asp Thr Val Glu Leu Thr Cys Thr Ala Ser Gln Lys Lys Ser 
        35                  40                  45              


Ile Gln Phe His Trp Lys Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn 
    50                  55                  60                  


Gln Gly Ser Phe Leu Thr Lys Gly Pro Ser Lys Leu Asn Asp Arg Ala 
65                  70                  75                  80  


Asp Ser Arg Arg Ser Leu Trp Asp Gln Gly Asn Phe Pro Leu Ile Ile 
                85                  90                  95      


Lys Asn Leu Lys Ile Glu Asp Ser Asp Thr Tyr Ile Cys Glu Val Glu 
            100                 105                 110         


Asp Gln Lys Glu Glu Val Gln Leu Leu Val Phe Gly Leu Thr Ala Asn 
        115                 120                 125             


Ser Asp Thr His Leu Leu Gln Gly Gln Ser Leu Thr Leu Thr Leu Glu 
    130                 135                 140                 


Ser Pro Pro Gly Ser Ser Pro Ser Val Gln Cys Arg Ser Pro Arg Gly 
145                 150                 155                 160 


Lys Asn Ile Gln Gly Gly Lys Thr Leu Ser Val Ser Gln Leu Glu Leu 
                165                 170                 175     


Gln Asp Ser Gly Thr Trp Thr Cys Thr Val Leu Gln Asn Gln Lys Lys 
            180                 185                 190         


Val Glu Phe Lys Ile Asp Ile Val Val Leu Ala Phe Gln Lys Ala Ser 
        195                 200                 205             


Ser Ile Val Tyr Lys Lys Glu Gly Glu Gln Val Glu Phe Ser Phe Pro 
    210                 215                 220                 


Leu Ala Phe Thr Val Glu Lys Leu Thr Gly Ser Gly Glu Leu Trp Trp 
225                 230                 235                 240 


Gln Ala Glu Arg Ala Ser Ser Ser Lys Ser Trp Ile Thr Phe Asp Leu 
                245                 250                 255     


Lys Asn Lys Glu Val Ser Val Lys Arg Val Thr Gln Asp Pro Lys Leu 
            260                 265                 270         


Gln Met Gly Lys Lys Leu Pro Leu His Leu Thr Leu Pro Gln Ala Leu 
        275                 280                 285             


Pro Gln Tyr Ala Gly Ser Gly Asn Leu Thr Leu Ala Leu Glu Ala Lys 
    290                 295                 300                 


Thr Gly Lys Leu His Gln Glu Val Asn Leu Val Val Met Arg Ala Thr 
305                 310                 315                 320 


Gln Leu Gln Lys Asn Leu Thr Cys Glu Val Trp Gly Pro Thr Ser Pro 
                325                 330                 335     


Lys Leu Met Leu Ser Leu Lys Leu Glu Asn Lys Glu Ala Lys Val Ser 
            340                 345                 350         


Lys Arg Glu Lys Ala Val Trp Val Leu Asn Pro Glu Ala Gly Met Trp 
        355                 360                 365             


Gln Cys Leu Leu Ser Asp Ser Gly Gln Val Leu Leu Glu Ser Asn Ile 
    370                 375                 380                 


Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala Leu Ile 
385                 390                 395                 400 


Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile 
                405                 410                 415     


Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met 
            420                 425                 430         


Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro 
        435                 440                 445             


His Arg Phe Gln Lys Thr Cys Ser Pro Ile 
    450                 455             


<210>  14
<211>  235
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD8A(CD8-alpha)

<400>  14

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
        195                 200                 205             


Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 
    210                 215                 220                 


Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
225                 230                 235 


<210>  15
<211>  210
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD8B(CD8-beta)

<400>  15

Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Thr Val Leu 
1               5                   10                  15      


His Gly Asn Ser Val Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln 
            20                  25                  30          


Thr Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser 
        35                  40                  45              


Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp 
    50                  55                  60                  


Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile 
65                  70                  75                  80  


His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala 
                85                  90                  95      


Ser Arg Phe Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly 
            100                 105                 110         


Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys 
        115                 120                 125             


Gly Thr Gln Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro 
    130                 135                 140                 


Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro 
145                 150                 155                 160 


Glu Thr Gln Lys Gly Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu 
                165                 170                 175     


Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly Val Ala Ile His 
            180                 185                 190         


Leu Cys Cys Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Phe 
        195                 200                 205             


Tyr Lys 
    210 


<210>  16
<211>  525
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  LAG3

<400>  16

Met Trp Glu Ala Gln Phe Leu Gly Leu Leu Phe Leu Gln Pro Leu Trp 
1               5                   10                  15      


Val Ala Pro Val Lys Pro Leu Gln Pro Gly Ala Glu Val Pro Val Val 
            20                  25                  30          


Trp Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile 
        35                  40                  45              


Pro Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly Val Thr Trp Gln 
    50                  55                  60                  


His Gln Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro Gly His Pro Leu 
65                  70                  75                  80  


Ala Pro Gly Pro His Pro Ala Ala Pro Ser Ser Trp Gly Pro Arg Pro 
                85                  90                  95      


Arg Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly Leu Arg Ser Gly 
            100                 105                 110         


Arg Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu Arg Gly Arg Gln 
        115                 120                 125             


Arg Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala 
    130                 135                 140                 


Gly Glu Tyr Arg Ala Ala Val His Leu Arg Asp Arg Ala Leu Ser Cys 
145                 150                 155                 160 


Arg Leu Arg Leu Arg Leu Gly Gln Ala Ser Met Thr Ala Ser Pro Pro 
                165                 170                 175     


Gly Ser Leu Arg Ala Ser Asp Trp Val Ile Leu Asn Cys Ser Phe Ser 
            180                 185                 190         


Arg Pro Asp Arg Pro Ala Ser Val His Trp Phe Arg Asn Arg Gly Gln 
        195                 200                 205             


Gly Arg Val Pro Val Arg Glu Ser Pro His His His Leu Ala Glu Ser 
    210                 215                 220                 


Phe Leu Phe Leu Pro Gln Val Ser Pro Met Asp Ser Gly Pro Trp Gly 
225                 230                 235                 240 


Cys Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser Ile Met Tyr Asn 
                245                 250                 255     


Leu Thr Val Leu Gly Leu Glu Pro Pro Thr Pro Leu Thr Val Tyr Ala 
            260                 265                 270         


Gly Ala Gly Ser Arg Val Gly Leu Pro Cys Arg Leu Pro Ala Gly Val 
        275                 280                 285             


Gly Thr Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro Pro Gly Gly Gly 
    290                 295                 300                 


Pro Asp Leu Leu Val Thr Gly Asp Asn Gly Asp Phe Thr Leu Arg Leu 
305                 310                 315                 320 


Glu Asp Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr Cys His Ile His 
                325                 330                 335     


Leu Gln Glu Gln Gln Leu Asn Ala Thr Val Thr Leu Ala Ile Ile Thr 
            340                 345                 350         


Val Thr Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu Gly Lys Leu Leu 
        355                 360                 365             


Cys Glu Val Thr Pro Val Ser Gly Gln Glu Arg Phe Val Trp Ser Ser 
    370                 375                 380                 


Leu Asp Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro Trp Leu Glu Ala 
385                 390                 395                 400 


Gln Glu Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys Gln Leu Tyr Gln 
                405                 410                 415     


Gly Glu Arg Leu Leu Gly Ala Ala Val Tyr Phe Thr Glu Leu Ser Ser 
            420                 425                 430         


Pro Gly Ala Gln Arg Ser Gly Arg Ala Pro Gly Ala Leu Pro Ala Gly 
        435                 440                 445             


His Leu Leu Leu Phe Leu Ile Leu Gly Val Leu Ser Leu Leu Leu Leu 
    450                 455                 460                 


Val Thr Gly Ala Phe Gly Phe His Leu Trp Arg Arg Gln Trp Arg Pro 
465                 470                 475                 480 


Arg Arg Phe Ser Ala Leu Glu Gln Gly Ile His Pro Pro Gln Ala Gln 
                485                 490                 495     


Ser Lys Ile Glu Glu Leu Glu Gln Glu Pro Glu Pro Glu Pro Glu Pro 
            500                 505                 510         


Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Gln Leu 
        515                 520                 525 


<210>  17
<211>  301
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  HAVCR2(TIM-3)

<400>  17

Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu 
        35                  40                  45              


Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly 
    50                  55                  60                  


Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser 
65                  70                  75                  80  


Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr 
                85                  90                  95      


Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile 
            100                 105                 110         


Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val 
        115                 120                 125             


Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe 
    130                 135                 140                 


Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile 
                165                 170                 175     


Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu 
            180                 185                 190         


Arg Asp Ser Gly Ala Thr Ile Arg Ile Gly Ile Tyr Ile Gly Ala Gly 
        195                 200                 205             


Ile Cys Ala Gly Leu Ala Leu Ala Leu Ile Phe Gly Ala Leu Ile Phe 
    210                 215                 220                 


Lys Trp Tyr Ser His Ser Lys Glu Lys Ile Gln Asn Leu Ser Leu Ile 
225                 230                 235                 240 


Ser Leu Ala Asn Leu Pro Pro Ser Gly Leu Ala Asn Ala Val Ala Glu 
                245                 250                 255     


Gly Ile Arg Ser Glu Glu Asn Ile Tyr Thr Ile Glu Glu Asn Val Tyr 
            260                 265                 270         


Glu Val Glu Glu Pro Asn Glu Tyr Tyr Cys Tyr Val Ser Ser Arg Gln 
        275                 280                 285             


Gln Pro Ser Gln Pro Leu Gly Cys Arg Phe Ala Met Pro 
    290                 295                 300     


<210>  18
<211>  526
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CEACAM1

<400>  18

Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Thr Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu 
305                 310                 315                 320 


Leu Ser Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Thr Thr 
                325                 330                 335     


Val Thr Gly Asp Lys Asp Ser Val Asn Leu Thr Cys Ser Thr Asn Asp 
            340                 345                 350         


Thr Gly Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser 
        355                 360                 365             


Ser Glu Arg Met Lys Leu Ser Gln Gly Asn Thr Thr Leu Ser Ile Asn 
    370                 375                 380                 


Pro Val Lys Arg Glu Asp Ala Gly Thr Tyr Trp Cys Glu Val Phe Asn 
385                 390                 395                 400 


Pro Ile Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr 
                405                 410                 415     


Asn Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly 
            420                 425                 430         


Ile Val Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu 
        435                 440                 445             


Ala Cys Phe Leu His Phe Gly Lys Thr Gly Arg Ala Ser Asp Gln Arg 
    450                 455                 460                 


Asp Leu Thr Glu His Lys Pro Ser Val Ser Asn His Thr Gln Asp His 
465                 470                 475                 480 


Ser Asn Asp Pro Pro Asn Lys Met Asn Glu Val Thr Tyr Ser Thr Leu 
                485                 490                 495     


Asn Phe Glu Ala Gln Gln Pro Thr Gln Pro Thr Ser Ala Ser Pro Ser 
            500                 505                 510         


Leu Thr Ala Thr Glu Ile Ile Tyr Ser Glu Val Lys Lys Gln 
        515                 520                 525     


<210>  19
<211>  244
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  TIGIT

<400>  19

Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln Ala 
1               5                   10                  15      


Pro Leu Ala Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn 
            20                  25                  30          


Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser 
        35                  40                  45              


Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln 
    50                  55                  60                  


Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser 
65                  70                  75                  80  


Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln 
                85                  90                  95      


Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr 
            100                 105                 110         


Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu 
        115                 120                 125             


Ser Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Leu Leu Gly 
    130                 135                 140                 


Ala Met Ala Ala Thr Leu Val Val Ile Cys Thr Ala Val Ile Val Val 
145                 150                 155                 160 


Val Ala Leu Thr Arg Lys Lys Lys Ala Leu Arg Ile His Ser Val Glu 
                165                 170                 175     


Gly Asp Leu Arg Arg Lys Ser Ala Gly Gln Glu Glu Trp Ser Pro Ser 
            180                 185                 190         


Ala Pro Ser Pro Pro Gly Ser Cys Val Gln Ala Glu Ala Ala Pro Ala 
        195                 200                 205             


Gly Leu Cys Gly Glu Gln Arg Gly Glu Asp Cys Ala Glu Leu His Asp 
    210                 215                 220                 


Tyr Phe Asn Val Leu Ser Tyr Arg Ser Leu Gly Asn Cys Ser Phe Phe 
225                 230                 235                 240 


Thr Glu Thr Gly 
                


<210>  20
<211>  417
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  PVR(CD155)

<400>  20

Met Ala Arg Ala Met Ala Ala Ala Trp Pro Leu Leu Leu Val Ala Leu 
1               5                   10                  15      


Leu Val Leu Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln 
            20                  25                  30          


Ala Pro Thr Gln Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro 
        35                  40                  45              


Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu 
    50                  55                  60                  


Thr Trp Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln 
65                  70                  75                  80  


Thr Gln Gly Pro Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala 
                85                  90                  95      


Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly 
            100                 105                 110         


Leu Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe 
        115                 120                 125             


Pro Gln Gly Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys 
    130                 135                 140                 


Pro Gln Asn Thr Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro 
145                 150                 155                 160 


Val Pro Met Ala Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln 
                165                 170                 175     


Ile Thr Trp His Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val 
            180                 185                 190         


Pro Gly Phe Leu Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu 
        195                 200                 205             


Val Pro Ser Ser Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu 
    210                 215                 220                 


His Glu Ser Phe Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val 
225                 230                 235                 240 


Tyr Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr 
                245                 250                 255     


Leu Gly Gln Asn Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro 
            260                 265                 270         


Glu Pro Thr Gly Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro 
        275                 280                 285             


Phe Ala Val Ala Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys 
    290                 295                 300                 


Pro Ile Asn Thr Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala 
305                 310                 315                 320 


Arg Gln Ala Glu Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu 
                325                 330                 335     


His Ser Gly Ile Ser Arg Asn Ala Ile Ile Phe Leu Val Leu Gly Ile 
            340                 345                 350         


Leu Val Phe Leu Ile Leu Leu Gly Ile Gly Ile Tyr Phe Tyr Trp Ser 
        355                 360                 365             


Lys Cys Ser Arg Glu Val Leu Trp His Cys His Leu Cys Pro Ser Ser 
    370                 375                 380                 


Thr Glu His Ala Ser Ala Ser Ala Asn Gly His Val Ser Tyr Ser Ala 
385                 390                 395                 400 


Val Ser Arg Glu Asn Ser Ser Ser Gln Asp Pro Gln Thr Glu Gly Thr 
                405                 410                 415     


Arg 
    


<210>  21
<211>  538
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  PVRL2(CD112)

<400>  21

Met Ala Arg Ala Ala Ala Leu Leu Pro Ser Arg Ser Pro Pro Thr Pro 
1               5                   10                  15      


Leu Leu Trp Pro Leu Leu Leu Leu Leu Leu Leu Glu Thr Gly Ala Gln 
            20                  25                  30          


Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly Gly 
        35                  40                  45              


Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu Tyr 
    50                  55                  60                  


Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His Gln 
65                  70                  75                  80  


Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser Pro 
                85                  90                  95      


Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser Thr 
            100                 105                 110         


Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu His 
        115                 120                 125             


Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala Thr 
    130                 135                 140                 


Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile Ala 
145                 150                 155                 160 


Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln Asp 
                165                 170                 175     


Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro Ala 
            180                 185                 190         


Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr Gln 
        195                 200                 205             


Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe Thr 
    210                 215                 220                 


Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys Val 
225                 230                 235                 240 


Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu Ser 
                245                 250                 255     


Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn Trp 
            260                 265                 270         


Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser Asn 
        275                 280                 285             


Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe Pro 
    290                 295                 300                 


Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val Asp 
305                 310                 315                 320 


Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val Gly 
                325                 330                 335     


Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn Thr 
            340                 345                 350         


Ala Gly Ala Gly Ala Thr Gly Gly Ile Ile Gly Gly Ile Ile Ala Ala 
        355                 360                 365             


Ile Ile Ala Thr Ala Val Ala Ala Thr Gly Ile Leu Ile Cys Arg Gln 
    370                 375                 380                 


Gln Arg Lys Glu Gln Thr Leu Gln Gly Ala Glu Glu Asp Glu Asp Leu 
385                 390                 395                 400 


Glu Gly Pro Pro Ser Tyr Lys Pro Pro Thr Pro Lys Ala Lys Leu Glu 
                405                 410                 415     


Ala Gln Glu Met Pro Ser Gln Leu Phe Thr Leu Gly Ala Ser Glu His 
            420                 425                 430         


Ser Pro Leu Lys Thr Pro Tyr Phe Asp Ala Gly Ala Ser Cys Thr Glu 
        435                 440                 445             


Gln Glu Met Pro Arg Tyr His Glu Leu Pro Thr Leu Glu Glu Arg Ser 
    450                 455                 460                 


Gly Pro Leu His Pro Gly Ala Thr Ser Leu Gly Ser Pro Ile Pro Val 
465                 470                 475                 480 


Pro Pro Gly Pro Pro Ala Val Glu Asp Val Ser Leu Asp Leu Glu Asp 
                485                 490                 495     


Glu Glu Gly Glu Glu Glu Glu Glu Tyr Leu Asp Lys Ile Asn Pro Ile 
            500                 505                 510         


Tyr Asp Ala Leu Ser Tyr Ser Ser Pro Ser Asp Ser Tyr Gln Gly Lys 
        515                 520                 525             


Gly Phe Val Met Ser Arg Ala Met Tyr Val 
    530                 535             


<210>  22
<211>  336
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD226

<400>  22

Met Asp Tyr Pro Thr Leu Leu Leu Ala Leu Leu His Val Tyr Arg Ala 
1               5                   10                  15      


Leu Cys Glu Glu Val Leu Trp His Thr Ser Val Pro Phe Ala Glu Asn 
            20                  25                  30          


Met Ser Leu Glu Cys Val Tyr Pro Ser Met Gly Ile Leu Thr Gln Val 
        35                  40                  45              


Glu Trp Phe Lys Ile Gly Thr Gln Gln Asp Ser Ile Ala Ile Phe Ser 
    50                  55                  60                  


Pro Thr His Gly Met Val Ile Arg Lys Pro Tyr Ala Glu Arg Val Tyr 
65                  70                  75                  80  


Phe Leu Asn Ser Thr Met Ala Ser Asn Asn Met Thr Leu Phe Phe Arg 
                85                  90                  95      


Asn Ala Ser Glu Asp Asp Val Gly Tyr Tyr Ser Cys Ser Leu Tyr Thr 
            100                 105                 110         


Tyr Pro Gln Gly Thr Trp Gln Lys Val Ile Gln Val Val Gln Ser Asp 
        115                 120                 125             


Ser Phe Glu Ala Ala Val Pro Ser Asn Ser His Ile Val Ser Glu Pro 
    130                 135                 140                 


Gly Lys Asn Val Thr Leu Thr Cys Gln Pro Gln Met Thr Trp Pro Val 
145                 150                 155                 160 


Gln Ala Val Arg Trp Glu Lys Ile Gln Pro Arg Gln Ile Asp Leu Leu 
                165                 170                 175     


Thr Tyr Cys Asn Leu Val His Gly Arg Asn Phe Thr Ser Lys Phe Pro 
            180                 185                 190         


Arg Gln Ile Val Ser Asn Cys Ser His Gly Arg Trp Ser Val Ile Val 
        195                 200                 205             


Ile Pro Asp Val Thr Val Ser Asp Ser Gly Leu Tyr Arg Cys Tyr Leu 
    210                 215                 220                 


Gln Ala Ser Ala Gly Glu Asn Glu Thr Phe Val Met Arg Leu Thr Val 
225                 230                 235                 240 


Ala Glu Gly Lys Thr Asp Asn Gln Tyr Thr Leu Phe Val Ala Gly Gly 
                245                 250                 255     


Thr Val Leu Leu Leu Leu Phe Val Ile Ser Ile Thr Thr Ile Ile Val 
            260                 265                 270         


Ile Phe Leu Asn Arg Arg Arg Arg Arg Glu Arg Arg Asp Leu Phe Thr 
        275                 280                 285             


Glu Ser Trp Asp Thr Gln Lys Ala Pro Asn Asn Tyr Arg Ser Pro Ile 
    290                 295                 300                 


Ser Thr Ser Gln Pro Thr Asn Gln Ser Met Asp Asp Thr Arg Glu Asp 
305                 310                 315                 320 


Ile Tyr Val Asn Tyr Pro Thr Phe Ser Arg Arg Pro Lys Thr Arg Val 
                325                 330                 335     


<210>  23
<211>  351
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD2

<400>  23

Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn 
1               5                   10                  15      


Val Ser Ser Lys Gly Ala Val Ser Lys Glu Ile Thr Asn Ala Leu Glu 
            20                  25                  30          


Thr Trp Gly Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe 
        35                  40                  45              


Gln Met Ser Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp 
    50                  55                  60                  


Lys Lys Lys Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu 
65                  70                  75                  80  


Lys Asp Thr Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His 
                85                  90                  95      


Leu Lys Thr Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr Asp Thr 
            100                 105                 110         


Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu 
        115                 120                 125             


Arg Val Ser Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu 
    130                 135                 140                 


Thr Cys Glu Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln 
145                 150                 155                 160 


Asp Gly Lys His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp 
                165                 170                 175     


Thr Thr Ser Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val 
            180                 185                 190         


Ser Lys Glu Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu 
        195                 200                 205             


Asp Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met 
    210                 215                 220                 


Val Phe Val Ala Leu Leu Val Phe Tyr Ile Thr Lys Arg Lys Lys Gln 
225                 230                 235                 240 


Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr Arg Ala His Arg Val 
                245                 250                 255     


Ala Thr Glu Glu Arg Gly Arg Lys Pro His Gln Ile Pro Ala Ser Thr 
            260                 265                 270         


Pro Gln Asn Pro Ala Thr Ser Gln His Pro Pro Pro Pro Pro Gly His 
        275                 280                 285             


Arg Ser Gln Ala Pro Ser His Arg Pro Pro Pro Pro Gly His Arg Val 
    290                 295                 300                 


Gln His Gln Pro Gln Lys Arg Pro Pro Ala Pro Ser Gly Thr Gln Val 
305                 310                 315                 320 


His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro Arg Val Gln Pro Lys 
                325                 330                 335     


Pro Pro His Gly Ala Ala Glu Asn Ser Leu Ser Pro Ser Ser Asn 
            340                 345                 350     


<210>  24
<211>  180
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD160

<400>  24

Met Leu Leu Glu Pro Gly Arg Gly Cys Cys Ala Leu Ala Ile Leu Leu 
1               5                   10                  15      


Ala Ile Val Asp Ile Gln Ser Gly Gly Cys Ile Asn Ile Thr Ser Ser 
            20                  25                  30          


Ala Ser Gln Glu Gly Thr Arg Leu Asn Leu Ile Cys Thr Val Trp His 
        35                  40                  45              


Lys Lys Glu Glu Ala Glu Gly Phe Val Val Phe Leu Cys Lys Asp Arg 
    50                  55                  60                  


Ser Gly Asp Cys Ser Pro Glu Thr Ser Leu Lys Gln Leu Arg Leu Lys 
65                  70                  75                  80  


Arg Asp Pro Gly Ile Asp Gly Val Gly Glu Ile Ser Ser Gln Leu Met 
                85                  90                  95      


Phe Thr Ile Ser Gln Val Thr Pro Leu His Ser Gly Thr Tyr Gln Cys 
            100                 105                 110         


Cys Ala Arg Ser Gln Lys Ser Gly Ile Arg Leu Gln Gly His Phe Phe 
        115                 120                 125             


Ser Ile Leu Phe Thr Glu Thr Gly Asn Tyr Thr Val Thr Gly Leu Lys 
    130                 135                 140                 


Gln Arg Gln His Leu Glu Phe Ser His Asn Glu Gly Thr Leu Ser Ser 
145                 150                 155                 160 


Gly Phe Leu Gln Glu Lys Val Trp Val Met Leu Val Thr Ser Leu Val 
                165                 170                 175     


Ala Leu Gln Ala 
            180 


<210>  25
<211>  278
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD200

<400>  25

Met Glu Arg Leu Val Ile Arg Met Pro Phe Ser His Leu Ser Thr Tyr 
1               5                   10                  15      


Ser Leu Val Trp Val Met Ala Ala Val Val Leu Cys Thr Ala Gln Val 
            20                  25                  30          


Gln Val Val Thr Gln Asp Glu Arg Glu Gln Leu Tyr Thr Pro Ala Ser 
        35                  40                  45              


Leu Lys Cys Ser Leu Gln Asn Ala Gln Glu Ala Leu Ile Val Thr Trp 
    50                  55                  60                  


Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr Phe Ser Glu 
65                  70                  75                  80  


Asn His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Lys Ile Asn Ile 
                85                  90                  95      


Thr Gln Leu Gly Leu Gln Asn Ser Thr Ile Thr Phe Trp Asn Ile Thr 
            100                 105                 110         


Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe Gly Phe 
        115                 120                 125             


Gly Lys Ile Ser Gly Thr Ala Cys Leu Thr Val Tyr Val Gln Pro Ile 
    130                 135                 140                 


Val Ser Leu His Tyr Lys Phe Ser Glu Asp His Leu Asn Ile Thr Cys 
145                 150                 155                 160 


Ser Ala Thr Ala Arg Pro Ala Pro Met Val Phe Trp Lys Val Pro Arg 
                165                 170                 175     


Ser Gly Ile Glu Asn Ser Thr Val Thr Leu Ser His Pro Asn Gly Thr 
            180                 185                 190         


Thr Ser Val Thr Ser Ile Leu His Ile Lys Asp Pro Lys Asn Gln Val 
        195                 200                 205             


Gly Lys Glu Val Ile Cys Gln Val Leu His Leu Gly Thr Val Thr Asp 
    210                 215                 220                 


Phe Lys Gln Thr Val Asn Lys Gly Tyr Trp Phe Ser Val Pro Leu Leu 
225                 230                 235                 240 


Leu Ser Ile Val Ser Leu Val Ile Leu Leu Val Leu Ile Ser Ile Leu 
                245                 250                 255     


Leu Tyr Trp Lys Arg His Arg Asn Gln Asp Arg Gly Glu Leu Ser Gln 
            260                 265                 270         


Gly Val Gln Lys Met Thr 
        275             


<210>  26
<211>  325
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD200R1(CD200R)

<400>  26

Met Leu Cys Pro Trp Arg Thr Ala Asn Leu Gly Leu Leu Leu Ile Leu 
1               5                   10                  15      


Thr Ile Phe Leu Val Ala Ala Ser Ser Ser Leu Cys Met Asp Glu Lys 
            20                  25                  30          


Gln Ile Thr Gln Asn Tyr Ser Lys Val Leu Ala Glu Val Asn Thr Ser 
        35                  40                  45              


Trp Pro Val Lys Met Ala Thr Asn Ala Val Leu Cys Cys Pro Pro Ile 
    50                  55                  60                  


Ala Leu Arg Asn Leu Ile Ile Ile Thr Trp Glu Ile Ile Leu Arg Gly 
65                  70                  75                  80  


Gln Pro Ser Cys Thr Lys Ala Tyr Arg Lys Glu Thr Asn Glu Thr Lys 
                85                  90                  95      


Glu Thr Asn Cys Thr Asp Glu Arg Ile Thr Trp Val Ser Arg Pro Asp 
            100                 105                 110         


Gln Asn Ser Asp Leu Gln Ile Arg Pro Val Ala Ile Thr His Asp Gly 
        115                 120                 125             


Tyr Tyr Arg Cys Ile Met Val Thr Pro Asp Gly Asn Phe His Arg Gly 
    130                 135                 140                 


Tyr His Leu Gln Val Leu Val Thr Pro Glu Val Thr Leu Phe Gln Asn 
145                 150                 155                 160 


Arg Asn Arg Thr Ala Val Cys Lys Ala Val Ala Gly Lys Pro Ala Ala 
                165                 170                 175     


Gln Ile Ser Trp Ile Pro Glu Gly Asp Cys Ala Thr Lys Gln Glu Tyr 
            180                 185                 190         


Trp Ser Asn Gly Thr Val Thr Val Lys Ser Thr Cys His Trp Glu Val 
        195                 200                 205             


His Asn Val Ser Thr Val Thr Cys His Val Ser His Leu Thr Gly Asn 
    210                 215                 220                 


Lys Ser Leu Tyr Ile Glu Leu Leu Pro Val Pro Gly Ala Lys Lys Ser 
225                 230                 235                 240 


Ala Lys Leu Tyr Ile Pro Tyr Ile Ile Leu Thr Ile Ile Ile Leu Thr 
                245                 250                 255     


Ile Val Gly Phe Ile Trp Leu Leu Lys Val Asn Gly Cys Arg Lys Tyr 
            260                 265                 270         


Lys Leu Asn Lys Thr Glu Ser Thr Pro Val Val Glu Glu Asp Glu Met 
        275                 280                 285             


Gln Pro Tyr Ala Ser Tyr Thr Glu Lys Asn Asn Pro Leu Tyr Asp Thr 
    290                 295                 300                 


Thr Asn Lys Val Lys Ala Ser Glu Ala Leu Gln Ser Glu Val Asp Thr 
305                 310                 315                 320 


Asp Leu His Thr Leu 
                325 


<210>  27
<211>  201
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  NC R3 (NKp30)

<400>  27

Met Ala Trp Met Leu Leu Leu Ile Leu Ile Met Val His Pro Gly Ser 
1               5                   10                  15      


Cys Ala Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly 
            20                  25                  30          


Ser Ser Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu 
        35                  40                  45              


Ala Ile Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys 
    50                  55                  60                  


Glu Val Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu 
65                  70                  75                  80  


Ala Ser Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg 
                85                  90                  95      


Asp Val Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val 
            100                 105                 110         


Leu Gly Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu 
        115                 120                 125             


Lys Glu His Pro Gln Leu Gly Ala Gly Thr Val Leu Leu Leu Arg Ala 
    130                 135                 140                 


Gly Phe Tyr Ala Val Ser Phe Leu Ser Val Ala Val Gly Ser Thr Val 
145                 150                 155                 160 


Tyr Tyr Gln Gly Lys Cys Leu Thr Trp Lys Gly Pro Arg Arg Gln Leu 
                165                 170                 175     


Pro Ala Val Val Pro Ala Pro Leu Pro Pro Pro Cys Gly Ser Ser Ala 
            180                 185                 190         


His Leu Leu Pro Pro Val Pro Gly Gly 
        195                 200     


<210>  28
<211>  208
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD80(B7-1) ECD

<400>  28

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


<210>  29
<211>  224
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD86(B7-2) ECD

<400>  29

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly 
                85                  90                  95      


Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
            100                 105                 110         


Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val 
        115                 120                 125             


Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys 
    130                 135                 140                 


Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp 
145                 150                 155                 160 


Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val 
                165                 170                 175     


Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr 
            180                 185                 190         


Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro 
        195                 200                 205             


Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro 
    210                 215                 220                 


<210>  30
<211>  220
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD274 (PD-L1, B7-H1) ECD

<400>  30

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  31
<211>  201
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  PDCD1LG2(PD-L2, CD273) ECD

<400>  31

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr 
        195                 200     


<210>  32
<211>  238
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  ICOSLG(B7RP1, CD275, ICOSL, B7-H2) ECD

<400>  32

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr 
225                 230                 235             


<210>  33
<211>  438
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD276(B7-H3) ECD

<400>  33

Leu Glu Val Gln Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr 
1               5                   10                  15      


Asp Ala Thr Leu Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu 
            20                  25                  30          


Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val 
        35                  40                  45              


His Ser Phe Ala Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg 
    50                  55                  60                  


Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg 
65                  70                  75                  80  


Leu Gln Arg Val Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val 
                85                  90                  95      


Ser Ile Arg Asp Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala 
            100                 105                 110         


Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg 
        115                 120                 125             


Pro Gly Asp Thr Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro 
    130                 135                 140                 


Glu Ala Glu Val Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly 
145                 150                 155                 160 


Asn Val Thr Thr Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val 
                165                 170                 175     


His Ser Ile Leu Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys 
            180                 185                 190         


Leu Val Arg Asn Pro Val Leu Gln Gln Asp Ala His Ser Ser Val Thr 
        195                 200                 205             


Ile Thr Pro Gln Arg Ser Pro Thr Gly Ala Val Glu Val Gln Val Pro 
    210                 215                 220                 


Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu Arg Cys 
225                 230                 235                 240 


Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile 
                245                 250                 255     


Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Thr Glu Gly 
            260                 265                 270         


Arg Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp 
        275                 280                 285             


Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val Arg Val 
    290                 295                 300                 


Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp Phe Gly 
305                 310                 315                 320 


Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser 
                325                 330                 335     


Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr 
            340                 345                 350         


Ile Thr Cys Ser Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val Phe Trp 
        355                 360                 365             


Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln 
    370                 375                 380                 


Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Val Leu Arg Val 
385                 390                 395                 400 


Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val 
                405                 410                 415     


Leu Gln Gln Asp Ala His Gly Ser Val Thr Ile Thr Gly Gln Pro Met 
            420                 425                 430         


Thr Phe Pro Pro Glu Ala 
        435             


<210>  34
<211>  235
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  VTCN1(B7-H4) ECD

<400>  34

Leu Ile Ile Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
1               5                   10                  15      


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys 
            20                  25                  30          


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
        35                  40                  45              


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
    50                  55                  60                  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
65                  70                  75                  80  


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
                85                  90                  95      


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
            100                 105                 110         


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
        115                 120                 125             


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
    130                 135                 140                 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
145                 150                 155                 160 


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
                165                 170                 175     


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
            180                 185                 190         


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
        195                 200                 205             


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
    210                 215                 220                 


Ser His Leu Gln Leu Leu Asn Ser Lys Ala Ser 
225                 230                 235 


<210>  35
<211>  134
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD28 ECD

<400>  35

Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn 
1               5                   10                  15      


Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu 
            20                  25                  30          


Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys 
        35                  40                  45              


Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr 
    50                  55                  60                  


Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr 
65                  70                  75                  80  


Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile 
                85                  90                  95      


Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly 
            100                 105                 110         


Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
        115                 120                 125             


Pro Gly Pro Ser Lys Pro 
    130                 


<210>  36
<211>  126
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CTLA4 ECD

<400>  36

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  37
<211>  150
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  PDCD1(PD-1) ECD

<400>  37

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  38
<211>  120
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  ICOS ECD

<400>  38

Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile Phe His Asn Gly 
1               5                   10                  15      


Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val Gln Gln Phe Lys 
            20                  25                  30          


Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp Leu Thr Lys Thr 
        35                  40                  45              


Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu Lys Phe Cys His 
    50                  55                  60                  


Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu Tyr Asn Leu Asp 
65                  70                  75                  80  


His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser Ile Phe Asp Pro 
                85                  90                  95      


Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu His Ile Tyr Glu 
            100                 105                 110         


Ser Gln Leu Cys Cys Gln Leu Lys 
        115                 120 


<210>  39
<211>  127
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  BTLA(CD272) ECD

<400>  39

Lys Glu Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Glu His 
1               5                   10                  15      


Ser Ile Leu Ala Gly Asp Pro Phe Glu Leu Glu Cys Pro Val Lys Tyr 
            20                  25                  30          


Cys Ala Asn Arg Pro His Val Thr Trp Cys Lys Leu Asn Gly Thr Thr 
        35                  40                  45              


Cys Val Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys Glu Glu Lys Asn 
    50                  55                  60                  


Ile Ser Phe Phe Ile Leu His Phe Glu Pro Val Leu Pro Asn Asp Asn 
65                  70                  75                  80  


Gly Ser Tyr Arg Cys Ser Ala Asn Phe Gln Ser Asn Leu Ile Glu Ser 
                85                  90                  95      


His Ser Thr Thr Leu Tyr Val Thr Asp Val Lys Ser Ala Ser Glu Arg 
            100                 105                 110         


Pro Ser Lys Asp Glu Met Ala Ser Arg Pro Trp Leu Leu Tyr Arg 
        115                 120                 125         


<210>  40
<211>  371
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD4 ECD

<400>  40

Lys Lys Val Val Leu Gly Lys Lys Gly Asp Thr Val Glu Leu Thr Cys 
1               5                   10                  15      


Thr Ala Ser Gln Lys Lys Ser Ile Gln Phe His Trp Lys Asn Ser Asn 
            20                  25                  30          


Gln Ile Lys Ile Leu Gly Asn Gln Gly Ser Phe Leu Thr Lys Gly Pro 
        35                  40                  45              


Ser Lys Leu Asn Asp Arg Ala Asp Ser Arg Arg Ser Leu Trp Asp Gln 
    50                  55                  60                  


Gly Asn Phe Pro Leu Ile Ile Lys Asn Leu Lys Ile Glu Asp Ser Asp 
65                  70                  75                  80  


Thr Tyr Ile Cys Glu Val Glu Asp Gln Lys Glu Glu Val Gln Leu Leu 
                85                  90                  95      


Val Phe Gly Leu Thr Ala Asn Ser Asp Thr His Leu Leu Gln Gly Gln 
            100                 105                 110         


Ser Leu Thr Leu Thr Leu Glu Ser Pro Pro Gly Ser Ser Pro Ser Val 
        115                 120                 125             


Gln Cys Arg Ser Pro Arg Gly Lys Asn Ile Gln Gly Gly Lys Thr Leu 
    130                 135                 140                 


Ser Val Ser Gln Leu Glu Leu Gln Asp Ser Gly Thr Trp Thr Cys Thr 
145                 150                 155                 160 


Val Leu Gln Asn Gln Lys Lys Val Glu Phe Lys Ile Asp Ile Val Val 
                165                 170                 175     


Leu Ala Phe Gln Lys Ala Ser Ser Ile Val Tyr Lys Lys Glu Gly Glu 
            180                 185                 190         


Gln Val Glu Phe Ser Phe Pro Leu Ala Phe Thr Val Glu Lys Leu Thr 
        195                 200                 205             


Gly Ser Gly Glu Leu Trp Trp Gln Ala Glu Arg Ala Ser Ser Ser Lys 
    210                 215                 220                 


Ser Trp Ile Thr Phe Asp Leu Lys Asn Lys Glu Val Ser Val Lys Arg 
225                 230                 235                 240 


Val Thr Gln Asp Pro Lys Leu Gln Met Gly Lys Lys Leu Pro Leu His 
                245                 250                 255     


Leu Thr Leu Pro Gln Ala Leu Pro Gln Tyr Ala Gly Ser Gly Asn Leu 
            260                 265                 270         


Thr Leu Ala Leu Glu Ala Lys Thr Gly Lys Leu His Gln Glu Val Asn 
        275                 280                 285             


Leu Val Val Met Arg Ala Thr Gln Leu Gln Lys Asn Leu Thr Cys Glu 
    290                 295                 300                 


Val Trp Gly Pro Thr Ser Pro Lys Leu Met Leu Ser Leu Lys Leu Glu 
305                 310                 315                 320 


Asn Lys Glu Ala Lys Val Ser Lys Arg Glu Lys Ala Val Trp Val Leu 
                325                 330                 335     


Asn Pro Glu Ala Gly Met Trp Gln Cys Leu Leu Ser Asp Ser Gly Gln 
            340                 345                 350         


Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr Trp Ser Thr Pro 
        355                 360                 365             


Val Gln Pro 
    370     


<210>  41
<211>  161
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD8A(CD8-alpha) ECD

<400>  41

Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr Trp Asn Leu Gly Glu 
1               5                   10                  15      


Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser Asn Pro Thr Ser Gly 
            20                  25                  30          


Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala Ala Ser Pro Thr Phe 
        35                  40                  45              


Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala Ala Glu Gly Leu Asp 
    50                  55                  60                  


Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp Thr Phe Val Leu Thr 
65                  70                  75                  80  


Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr Tyr Phe Cys Ser Ala 
                85                  90                  95      


Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu 
            100                 105                 110         


Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        115                 120                 125             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    130                 135                 140                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
145                 150                 155                 160 


Asp 
    


<210>  42
<211>  149
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD8B(CD8-beta) ECD

<400>  42

Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln Thr Asn Lys Met Val 
1               5                   10                  15      


Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser Asn Met Arg Ile Tyr 
            20                  25                  30          


Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp Ser His His Glu Phe 
        35                  40                  45              


Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile His Gly Glu Glu Val 
    50                  55                  60                  


Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala Ser Arg Phe Ile Leu 
65                  70                  75                  80  


Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly Ile Tyr Phe Cys Met 
                85                  90                  95      


Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys Gly Thr Gln Leu Ser 
            100                 105                 110         


Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro Thr Lys Lys Ser Thr 
        115                 120                 125             


Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro Glu Thr Gln Lys Gly 
    130                 135                 140                 


Pro Leu Cys Ser Pro 
145                 


<210>  43
<211>  422
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  LAG3 ECD

<400>  43

Val Pro Val Val Trp Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys 
1               5                   10                  15      


Ser Pro Thr Ile Pro Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly 
            20                  25                  30          


Val Thr Trp Gln His Gln Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro 
        35                  40                  45              


Gly His Pro Leu Ala Pro Gly Pro His Pro Ala Ala Pro Ser Ser Trp 
    50                  55                  60                  


Gly Pro Arg Pro Arg Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly 
65                  70                  75                  80  


Leu Arg Ser Gly Arg Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu 
                85                  90                  95      


Arg Gly Arg Gln Arg Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg 
            100                 105                 110         


Arg Ala Asp Ala Gly Glu Tyr Arg Ala Ala Val His Leu Arg Asp Arg 
        115                 120                 125             


Ala Leu Ser Cys Arg Leu Arg Leu Arg Leu Gly Gln Ala Ser Met Thr 
    130                 135                 140                 


Ala Ser Pro Pro Gly Ser Leu Arg Ala Ser Asp Trp Val Ile Leu Asn 
145                 150                 155                 160 


Cys Ser Phe Ser Arg Pro Asp Arg Pro Ala Ser Val His Trp Phe Arg 
                165                 170                 175     


Asn Arg Gly Gln Gly Arg Val Pro Val Arg Glu Ser Pro His His His 
            180                 185                 190         


Leu Ala Glu Ser Phe Leu Phe Leu Pro Gln Val Ser Pro Met Asp Ser 
        195                 200                 205             


Gly Pro Trp Gly Cys Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser 
    210                 215                 220                 


Ile Met Tyr Asn Leu Thr Val Leu Gly Leu Glu Pro Pro Thr Pro Leu 
225                 230                 235                 240 


Thr Val Tyr Ala Gly Ala Gly Ser Arg Val Gly Leu Pro Cys Arg Leu 
                245                 250                 255     


Pro Ala Gly Val Gly Thr Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro 
            260                 265                 270         


Pro Gly Gly Gly Pro Asp Leu Leu Val Thr Gly Asp Asn Gly Asp Phe 
        275                 280                 285             


Thr Leu Arg Leu Glu Asp Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr 
    290                 295                 300                 


Cys His Ile His Leu Gln Glu Gln Gln Leu Asn Ala Thr Val Thr Leu 
305                 310                 315                 320 


Ala Ile Ile Thr Val Thr Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu 
                325                 330                 335     


Gly Lys Leu Leu Cys Glu Val Thr Pro Val Ser Gly Gln Glu Arg Phe 
            340                 345                 350         


Val Trp Ser Ser Leu Asp Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro 
        355                 360                 365             


Trp Leu Glu Ala Gln Glu Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys 
    370                 375                 380                 


Gln Leu Tyr Gln Gly Glu Arg Leu Leu Gly Ala Ala Val Tyr Phe Thr 
385                 390                 395                 400 


Glu Leu Ser Ser Pro Gly Ala Gln Arg Ser Gly Arg Ala Pro Gly Ala 
                405                 410                 415     


Leu Pro Ala Gly His Leu 
            420         


<210>  44
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  HAVCR2(TIM-3) ECD

<400>  44

Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln Asn Ala Tyr Leu Pro 
1               5                   10                  15      


Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu Val Pro Val Cys Trp 
            20                  25                  30          


Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly Asn Val Val Leu Arg 
        35                  40                  45              


Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser Arg Tyr Trp Leu Asn 
    50                  55                  60                  


Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr Ile Glu Asn Val Thr 
65                  70                  75                  80  


Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile Gln Ile Pro Gly Ile 
                85                  90                  95      


Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val Ile Lys Pro Ala Lys 
            100                 105                 110         


Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe Thr Ala Ala Phe Pro 
        115                 120                 125             


Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala Glu Thr Gln Thr Leu 
    130                 135                 140                 


Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile Ser Thr Leu Ala Asn 
145                 150                 155                 160 


Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu Arg Asp Ser Gly Ala 
                165                 170                 175     


Thr Ile Arg Ile Gly 
            180     


<210>  45
<211>  394
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CEACAM1 ECD

<400>  45

Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly Lys Glu 
1               5                   10                  15      


Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly Tyr Ser 
            20                  25                  30          


Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val Gly Tyr 
        35                  40                  45              


Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser Gly Arg 
    50                  55                  60                  


Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val Thr Gln 
65                  70                  75                  80  


Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp Leu Val 
                85                  90                  95      


Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu Pro Lys 
            100                 105                 110         


Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys Asp Ala 
        115                 120                 125             


Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr Leu Trp 
    130                 135                 140                 


Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser 
145                 150                 155                 160 


Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn Asp Thr 
                165                 170                 175     


Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn Arg Ser 
            180                 185                 190         


Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro Thr Ile 
        195                 200                 205             


Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser Leu Ser 
    210                 215                 220                 


Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu Ile Asn 
225                 230                 235                 240 


Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn Ile Thr 
                245                 250                 255     


Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser Val Thr 
            260                 265                 270         


Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu Leu Ser 
        275                 280                 285             


Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Thr Thr Val Thr 
    290                 295                 300                 


Gly Asp Lys Asp Ser Val Asn Leu Thr Cys Ser Thr Asn Asp Thr Gly 
305                 310                 315                 320 


Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser Ser Glu 
                325                 330                 335     


Arg Met Lys Leu Ser Gln Gly Asn Thr Thr Leu Ser Ile Asn Pro Val 
            340                 345                 350         


Lys Arg Glu Asp Ala Gly Thr Tyr Trp Cys Glu Val Phe Asn Pro Ile 
        355                 360                 365             


Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr Asn Ala 
    370                 375                 380                 


Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly 
385                 390                 


<210>  46
<211>  120
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  TIGIT ECD

<400>  46

Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala Glu Lys 
1               5                   10                  15      


Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser Ser Thr Thr Ala Gln 
            20                  25                  30          


Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala Ile Cys 
        35                  40                  45              


Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys Asp Arg Val 
    50                  55                  60                  


Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr Val Asn 
65                  70                  75                  80  


Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp Gly Thr 
                85                  90                  95      


Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser Val Ala Glu 
            100                 105                 110         


His Gly Ala Arg Phe Gln Ile Pro 
        115                 120 


<210>  47
<211>  323
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  PVR(CD155) ECD

<400>  47

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  48
<211>  329
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  PVRL2(CD112) ECD

<400>  48

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly 
                325                 


<210>  49
<211>  236
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD226 ECD

<400>  49

Glu Glu Val Leu Trp His Thr Ser Val Pro Phe Ala Glu Asn Met Ser 
1               5                   10                  15      


Leu Glu Cys Val Tyr Pro Ser Met Gly Ile Leu Thr Gln Val Glu Trp 
            20                  25                  30          


Phe Lys Ile Gly Thr Gln Gln Asp Ser Ile Ala Ile Phe Ser Pro Thr 
        35                  40                  45              


His Gly Met Val Ile Arg Lys Pro Tyr Ala Glu Arg Val Tyr Phe Leu 
    50                  55                  60                  


Asn Ser Thr Met Ala Ser Asn Asn Met Thr Leu Phe Phe Arg Asn Ala 
65                  70                  75                  80  


Ser Glu Asp Asp Val Gly Tyr Tyr Ser Cys Ser Leu Tyr Thr Tyr Pro 
                85                  90                  95      


Gln Gly Thr Trp Gln Lys Val Ile Gln Val Val Gln Ser Asp Ser Phe 
            100                 105                 110         


Glu Ala Ala Val Pro Ser Asn Ser His Ile Val Ser Glu Pro Gly Lys 
        115                 120                 125             


Asn Val Thr Leu Thr Cys Gln Pro Gln Met Thr Trp Pro Val Gln Ala 
    130                 135                 140                 


Val Arg Trp Glu Lys Ile Gln Pro Arg Gln Ile Asp Leu Leu Thr Tyr 
145                 150                 155                 160 


Cys Asn Leu Val His Gly Arg Asn Phe Thr Ser Lys Phe Pro Arg Gln 
                165                 170                 175     


Ile Val Ser Asn Cys Ser His Gly Arg Trp Ser Val Ile Val Ile Pro 
            180                 185                 190         


Asp Val Thr Val Ser Asp Ser Gly Leu Tyr Arg Cys Tyr Leu Gln Ala 
        195                 200                 205             


Ser Ala Gly Glu Asn Glu Thr Phe Val Met Arg Leu Thr Val Ala Glu 
    210                 215                 220                 


Gly Lys Thr Asp Asn Gln Tyr Thr Leu Phe Val Ala 
225                 230                 235     


<210>  50
<211>  185
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD2 ECD

<400>  50

Lys Glu Ile Thr Asn Ala Leu Glu Thr Trp Gly Ala Leu Gly Gln Asp 
1               5                   10                  15      


Ile Asn Leu Asp Ile Pro Ser Phe Gln Met Ser Asp Asp Ile Asp Asp 
            20                  25                  30          


Ile Lys Trp Glu Lys Thr Ser Asp Lys Lys Lys Ile Ala Gln Phe Arg 
        35                  40                  45              


Lys Glu Lys Glu Thr Phe Lys Glu Lys Asp Thr Tyr Lys Leu Phe Lys 
    50                  55                  60                  


Asn Gly Thr Leu Lys Ile Lys His Leu Lys Thr Asp Asp Gln Asp Ile 
65                  70                  75                  80  


Tyr Lys Val Ser Ile Tyr Asp Thr Lys Gly Lys Asn Val Leu Glu Lys 
                85                  90                  95      


Ile Phe Asp Leu Lys Ile Gln Glu Arg Val Ser Lys Pro Lys Ile Ser 
            100                 105                 110         


Trp Thr Cys Ile Asn Thr Thr Leu Thr Cys Glu Val Met Asn Gly Thr 
        115                 120                 125             


Asp Pro Glu Leu Asn Leu Tyr Gln Asp Gly Lys His Leu Lys Leu Ser 
    130                 135                 140                 


Gln Arg Val Ile Thr His Lys Trp Thr Thr Ser Leu Ser Ala Lys Phe 
145                 150                 155                 160 


Lys Cys Thr Ala Gly Asn Lys Val Ser Lys Glu Ser Ser Val Glu Pro 
                165                 170                 175     


Val Ser Cys Pro Glu Lys Gly Leu Asp 
            180                 185 


<210>  51
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD160 ECD

<400>  51

Ile Asn Ile Thr Ser Ser Ala Ser Gln Glu Gly Thr Arg Leu Asn Leu 
1               5                   10                  15      


Ile Cys Thr Val Trp His Lys Lys Glu Glu Ala Glu Gly Phe Val Val 
            20                  25                  30          


Phe Leu Cys Lys Asp Arg Ser Gly Asp Cys Ser Pro Glu Thr Ser Leu 
        35                  40                  45              


Lys Gln Leu Arg Leu Lys Arg Asp Pro Gly Ile Asp Gly Val Gly Glu 
    50                  55                  60                  


Ile Ser Ser Gln Leu Met Phe Thr Ile Ser Gln Val Thr Pro Leu His 
65                  70                  75                  80  


Ser Gly Thr Tyr Gln Cys Cys Ala Arg Ser Gln Lys Ser Gly Ile Arg 
                85                  90                  95      


Leu Gln Gly His Phe Phe Ser Ile Leu Phe Thr Glu Thr Gly Asn Tyr 
            100                 105                 110         


Thr Val Thr Gly Leu Lys Gln Arg Gln His Leu Glu Phe Ser His Asn 
        115                 120                 125             


Glu Gly Thr Leu Ser 
    130             


<210>  52
<211>  202
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD200 ECD

<400>  52

Gln Val Gln Val Val Thr Gln Asp Glu Arg Glu Gln Leu Tyr Thr Pro 
1               5                   10                  15      


Ala Ser Leu Lys Cys Ser Leu Gln Asn Ala Gln Glu Ala Leu Ile Val 
            20                  25                  30          


Thr Trp Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr Phe 
        35                  40                  45              


Ser Glu Asn His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Lys Ile 
    50                  55                  60                  


Asn Ile Thr Gln Leu Gly Leu Gln Asn Ser Thr Ile Thr Phe Trp Asn 
65                  70                  75                  80  


Ile Thr Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe 
                85                  90                  95      


Gly Phe Gly Lys Ile Ser Gly Thr Ala Cys Leu Thr Val Tyr Val Gln 
            100                 105                 110         


Pro Ile Val Ser Leu His Tyr Lys Phe Ser Glu Asp His Leu Asn Ile 
        115                 120                 125             


Thr Cys Ser Ala Thr Ala Arg Pro Ala Pro Met Val Phe Trp Lys Val 
    130                 135                 140                 


Pro Arg Ser Gly Ile Glu Asn Ser Thr Val Thr Leu Ser His Pro Asn 
145                 150                 155                 160 


Gly Thr Thr Ser Val Thr Ser Ile Leu His Ile Lys Asp Pro Lys Asn 
                165                 170                 175     


Gln Val Gly Lys Glu Val Ile Cys Gln Val Leu His Leu Gly Thr Val 
            180                 185                 190         


Thr Asp Phe Lys Gln Thr Val Asn Lys Gly 
        195                 200         


<210>  53
<211>  215
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD200R1(CD200R) ECD

<400>  53

Met Asp Glu Lys Gln Ile Thr Gln Asn Tyr Ser Lys Val Leu Ala Glu 
1               5                   10                  15      


Val Asn Thr Ser Trp Pro Val Lys Met Ala Thr Asn Ala Val Leu Cys 
            20                  25                  30          


Cys Pro Pro Ile Ala Leu Arg Asn Leu Ile Ile Ile Thr Trp Glu Ile 
        35                  40                  45              


Ile Leu Arg Gly Gln Pro Ser Cys Thr Lys Ala Tyr Arg Lys Glu Thr 
    50                  55                  60                  


Asn Glu Thr Lys Glu Thr Asn Cys Thr Asp Glu Arg Ile Thr Trp Val 
65                  70                  75                  80  


Ser Arg Pro Asp Gln Asn Ser Asp Leu Gln Ile Arg Pro Val Ala Ile 
                85                  90                  95      


Thr His Asp Gly Tyr Tyr Arg Cys Ile Met Val Thr Pro Asp Gly Asn 
            100                 105                 110         


Phe His Arg Gly Tyr His Leu Gln Val Leu Val Thr Pro Glu Val Thr 
        115                 120                 125             


Leu Phe Gln Asn Arg Asn Arg Thr Ala Val Cys Lys Ala Val Ala Gly 
    130                 135                 140                 


Lys Pro Ala Ala Gln Ile Ser Trp Ile Pro Glu Gly Asp Cys Ala Thr 
145                 150                 155                 160 


Lys Gln Glu Tyr Trp Ser Asn Gly Thr Val Thr Val Lys Ser Thr Cys 
                165                 170                 175     


His Trp Glu Val His Asn Val Ser Thr Val Thr Cys His Val Ser His 
            180                 185                 190         


Leu Thr Gly Asn Lys Ser Leu Tyr Ile Glu Leu Leu Pro Val Pro Gly 
        195                 200                 205             


Ala Lys Lys Ser Ala Lys Leu 
    210                 215 


<210>  54
<211>  117
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  NC R3 (NKp30) ECD

<400>  54

Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser 
1               5                   10                  15      


Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu Ala Ile 
            20                  25                  30          


Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val 
        35                  40                  45              


Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu Ala Ser 
    50                  55                  60                  


Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val 
65                  70                  75                  80  


Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val Leu Gly 
                85                  90                  95      


Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu Lys Glu 
            100                 105                 110         


His Pro Gln Leu Gly 
        115         


<210>  55
<211>  254
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature CD80(B7-1)

<400>  55

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         


Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             


Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 


Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 


Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     


Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         


Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             


Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly Ile Phe 
    210                 215                 220                 


Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg Glu Arg 
225                 230                 235                 240 


Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val 
                245                 250                 


<210>  56
<211>  306
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature CD86(B7-2)

<400>  56

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly 
                85                  90                  95      


Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
            100                 105                 110         


Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val 
        115                 120                 125             


Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys 
    130                 135                 140                 


Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp 
145                 150                 155                 160 


Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val 
                165                 170                 175     


Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr 
            180                 185                 190         


Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro 
        195                 200                 205             


Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro 
    210                 215                 220                 


Trp Ile Thr Ala Val Leu Pro Thr Val Ile Ile Cys Val Met Val Phe 
225                 230                 235                 240 


Cys Leu Ile Leu Trp Lys Trp Lys Lys Lys Lys Arg Pro Arg Asn Ser 
                245                 250                 255     


Tyr Lys Cys Gly Thr Asn Thr Met Glu Arg Glu Glu Ser Glu Gln Thr 
            260                 265                 270         


Lys Lys Arg Glu Lys Ile His Ile Pro Glu Arg Ser Asp Glu Ala Gln 
        275                 280                 285             


Arg Val Phe Lys Ser Ser Lys Thr Ser Ser Cys Asp Lys Ser Asp Thr 
    290                 295                 300                 


Cys Phe 
305     


<210>  57
<211>  272
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature CD274 (PD-L1, B7-H1)

<400>  57

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His Leu Val 
    210                 215                 220                 


Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr Phe Ile 
225                 230                 235                 240 


Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys Gly Ile 
                245                 250                 255     


Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu Glu Thr 
            260                 265                 270         


<210>  58
<211>  254
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature PDCD1LG2(PD-L2, CD273)

<400>  58

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr Trp Leu Leu His Ile Phe Ile 
        195                 200                 205             


Pro Phe Cys Ile Ile Ala Phe Ile Phe Ile Ala Thr Val Ile Ala Leu 
    210                 215                 220                 


Arg Lys Gln Leu Cys Gln Lys Leu Tyr Ser Ser Lys Asp Thr Thr Lys 
225                 230                 235                 240 


Arg Pro Val Thr Thr Thr Lys Arg Glu Val Asn Ser Ala Ile 
                245                 250                 


<210>  59
<211>  284
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature ICOSLG(B7RP1, CD275, ICOSL, B7-H2)

<400>  59

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro 
        115                 120                 125             


His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn 
    130                 135                 140                 


Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser 
145                 150                 155                 160 


Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg 
                165                 170                 175     


Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser 
            180                 185                 190         


Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu 
        195                 200                 205             


Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile 
    210                 215                 220                 


Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr Trp Ser 
225                 230                 235                 240 


Ile Leu Ala Val Leu Cys Leu Leu Val Val Val Ala Val Ala Ile Gly 
                245                 250                 255     


Trp Val Cys Arg Asp Arg Cys Leu Gln His Ser Tyr Ala Gly Ala Trp 
            260                 265                 270         


Ala Val Ser Pro Glu Thr Glu Leu Thr Gly His Val 
        275                 280                 


<210>  60
<211>  506
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature CD276(B7-H3)

<400>  60

Leu Glu Val Gln Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr 
1               5                   10                  15      


Asp Ala Thr Leu Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu 
            20                  25                  30          


Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val 
        35                  40                  45              


His Ser Phe Ala Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg 
    50                  55                  60                  


Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg 
65                  70                  75                  80  


Leu Gln Arg Val Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val 
                85                  90                  95      


Ser Ile Arg Asp Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala 
            100                 105                 110         


Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg 
        115                 120                 125             


Pro Gly Asp Thr Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro 
    130                 135                 140                 


Glu Ala Glu Val Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly 
145                 150                 155                 160 


Asn Val Thr Thr Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val 
                165                 170                 175     


His Ser Ile Leu Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys 
            180                 185                 190         


Leu Val Arg Asn Pro Val Leu Gln Gln Asp Ala His Ser Ser Val Thr 
        195                 200                 205             


Ile Thr Pro Gln Arg Ser Pro Thr Gly Ala Val Glu Val Gln Val Pro 
    210                 215                 220                 


Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu Arg Cys 
225                 230                 235                 240 


Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile 
                245                 250                 255     


Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Thr Glu Gly 
            260                 265                 270         


Arg Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp 
        275                 280                 285             


Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val Arg Val 
    290                 295                 300                 


Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp Phe Gly 
305                 310                 315                 320 


Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser 
                325                 330                 335     


Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr 
            340                 345                 350         


Ile Thr Cys Ser Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val Phe Trp 
        355                 360                 365             


Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln 
    370                 375                 380                 


Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Val Leu Arg Val 
385                 390                 395                 400 


Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val 
                405                 410                 415     


Leu Gln Gln Asp Ala His Gly Ser Val Thr Ile Thr Gly Gln Pro Met 
            420                 425                 430         


Thr Phe Pro Pro Glu Ala Leu Trp Val Thr Val Gly Leu Ser Val Cys 
        435                 440                 445             


Leu Ile Ala Leu Leu Val Ala Leu Ala Phe Val Cys Trp Arg Lys Ile 
    450                 455                 460                 


Lys Gln Ser Cys Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln Asp Gly 
465                 470                 475                 480 


Glu Gly Glu Gly Ser Lys Thr Ala Leu Gln Pro Leu Lys His Ser Asp 
                485                 490                 495     


Ser Lys Glu Asp Asp Gly Gln Glu Ile Ala 
            500                 505     


<210>  61
<211>  258
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature VTCN1(B7-H4)

<400>  61

Leu Ile Ile Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
1               5                   10                  15      


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys 
            20                  25                  30          


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
        35                  40                  45              


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
    50                  55                  60                  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
65                  70                  75                  80  


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
                85                  90                  95      


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
            100                 105                 110         


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
        115                 120                 125             


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
    130                 135                 140                 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
145                 150                 155                 160 


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
                165                 170                 175     


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
            180                 185                 190         


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
        195                 200                 205             


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
    210                 215                 220                 


Ser His Leu Gln Leu Leu Asn Ser Lys Ala Ser Leu Cys Val Ser Ser 
225                 230                 235                 240 


Phe Phe Ala Ile Ser Trp Ala Leu Leu Pro Leu Ser Pro Tyr Leu Met 
                245                 250                 255     


Leu Lys 
        


<210>  62
<211>  202
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature CD28

<400>  62

Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn 
1               5                   10                  15      


Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu 
            20                  25                  30          


Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys 
        35                  40                  45              


Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr 
    50                  55                  60                  


Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr 
65                  70                  75                  80  


Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile 
                85                  90                  95      


Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly 
            100                 105                 110         


Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
        115                 120                 125             


Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val 
    130                 135                 140                 


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
145                 150                 155                 160 


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
                165                 170                 175     


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
            180                 185                 190         


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        195                 200         


<210>  63
<211>  188
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature CTLA4

<400>  63

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Phe Leu 
        115                 120                 125             


Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe Tyr Ser Phe 
    130                 135                 140                 


Leu Leu Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys Arg Ser Pro 
145                 150                 155                 160 


Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu Pro Glu Cys 
                165                 170                 175     


Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
            180                 185             


<210>  64
<211>  268
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature PDCD1(PD-1)

<400>  64

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly Leu Leu Gly Ser 
145                 150                 155                 160 


Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys Ser Arg Ala Ala 
                165                 170                 175     


Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp 
            180                 185                 190         


Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe 
        195                 200                 205             


Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu 
    210                 215                 220                 


Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser 
225                 230                 235                 240 


Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro 
                245                 250                 255     


Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
            260                 265             


<210>  65
<211>  179
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature ICOS

<400>  65

Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile Phe His Asn Gly 
1               5                   10                  15      


Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val Gln Gln Phe Lys 
            20                  25                  30          


Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp Leu Thr Lys Thr 
        35                  40                  45              


Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu Lys Phe Cys His 
    50                  55                  60                  


Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu Tyr Asn Leu Asp 
65                  70                  75                  80  


His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser Ile Phe Asp Pro 
                85                  90                  95      


Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu His Ile Tyr Glu 
            100                 105                 110         


Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro Ile Gly Cys Ala 
        115                 120                 125             


Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu Ile Cys Trp Leu 
    130                 135                 140                 


Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr 
145                 150                 155                 160 


Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp 
                165                 170                 175     


Val Thr Leu 
            


<210>  66
<211>  259
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature BTLA(CD272)

<400>  66

Lys Glu Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Glu His 
1               5                   10                  15      


Ser Ile Leu Ala Gly Asp Pro Phe Glu Leu Glu Cys Pro Val Lys Tyr 
            20                  25                  30          


Cys Ala Asn Arg Pro His Val Thr Trp Cys Lys Leu Asn Gly Thr Thr 
        35                  40                  45              


Cys Val Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys Glu Glu Lys Asn 
    50                  55                  60                  


Ile Ser Phe Phe Ile Leu His Phe Glu Pro Val Leu Pro Asn Asp Asn 
65                  70                  75                  80  


Gly Ser Tyr Arg Cys Ser Ala Asn Phe Gln Ser Asn Leu Ile Glu Ser 
                85                  90                  95      


His Ser Thr Thr Leu Tyr Val Thr Asp Val Lys Ser Ala Ser Glu Arg 
            100                 105                 110         


Pro Ser Lys Asp Glu Met Ala Ser Arg Pro Trp Leu Leu Tyr Arg Leu 
        115                 120                 125             


Leu Pro Leu Gly Gly Leu Pro Leu Leu Ile Thr Thr Cys Phe Cys Leu 
    130                 135                 140                 


Phe Cys Cys Leu Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser Asp 
145                 150                 155                 160 


Thr Ala Gly Arg Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu 
                165                 170                 175     


Gln Thr Glu Ala Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu 
            180                 185                 190         


Thr Gly Ile Tyr Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu 
        195                 200                 205             


Gly Ser Glu Val Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly 
    210                 215                 220                 


Ile Val Tyr Ala Ser Leu Asn His Ser Val Ile Gly Pro Asn Ser Arg 
225                 230                 235                 240 


Leu Ala Arg Asn Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys 
                245                 250                 255     


Val Arg Ser 
            


<210>  67
<211>  433
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature CD4

<400>  67

Lys Lys Val Val Leu Gly Lys Lys Gly Asp Thr Val Glu Leu Thr Cys 
1               5                   10                  15      


Thr Ala Ser Gln Lys Lys Ser Ile Gln Phe His Trp Lys Asn Ser Asn 
            20                  25                  30          


Gln Ile Lys Ile Leu Gly Asn Gln Gly Ser Phe Leu Thr Lys Gly Pro 
        35                  40                  45              


Ser Lys Leu Asn Asp Arg Ala Asp Ser Arg Arg Ser Leu Trp Asp Gln 
    50                  55                  60                  


Gly Asn Phe Pro Leu Ile Ile Lys Asn Leu Lys Ile Glu Asp Ser Asp 
65                  70                  75                  80  


Thr Tyr Ile Cys Glu Val Glu Asp Gln Lys Glu Glu Val Gln Leu Leu 
                85                  90                  95      


Val Phe Gly Leu Thr Ala Asn Ser Asp Thr His Leu Leu Gln Gly Gln 
            100                 105                 110         


Ser Leu Thr Leu Thr Leu Glu Ser Pro Pro Gly Ser Ser Pro Ser Val 
        115                 120                 125             


Gln Cys Arg Ser Pro Arg Gly Lys Asn Ile Gln Gly Gly Lys Thr Leu 
    130                 135                 140                 


Ser Val Ser Gln Leu Glu Leu Gln Asp Ser Gly Thr Trp Thr Cys Thr 
145                 150                 155                 160 


Val Leu Gln Asn Gln Lys Lys Val Glu Phe Lys Ile Asp Ile Val Val 
                165                 170                 175     


Leu Ala Phe Gln Lys Ala Ser Ser Ile Val Tyr Lys Lys Glu Gly Glu 
            180                 185                 190         


Gln Val Glu Phe Ser Phe Pro Leu Ala Phe Thr Val Glu Lys Leu Thr 
        195                 200                 205             


Gly Ser Gly Glu Leu Trp Trp Gln Ala Glu Arg Ala Ser Ser Ser Lys 
    210                 215                 220                 


Ser Trp Ile Thr Phe Asp Leu Lys Asn Lys Glu Val Ser Val Lys Arg 
225                 230                 235                 240 


Val Thr Gln Asp Pro Lys Leu Gln Met Gly Lys Lys Leu Pro Leu His 
                245                 250                 255     


Leu Thr Leu Pro Gln Ala Leu Pro Gln Tyr Ala Gly Ser Gly Asn Leu 
            260                 265                 270         


Thr Leu Ala Leu Glu Ala Lys Thr Gly Lys Leu His Gln Glu Val Asn 
        275                 280                 285             


Leu Val Val Met Arg Ala Thr Gln Leu Gln Lys Asn Leu Thr Cys Glu 
    290                 295                 300                 


Val Trp Gly Pro Thr Ser Pro Lys Leu Met Leu Ser Leu Lys Leu Glu 
305                 310                 315                 320 


Asn Lys Glu Ala Lys Val Ser Lys Arg Glu Lys Ala Val Trp Val Leu 
                325                 330                 335     


Asn Pro Glu Ala Gly Met Trp Gln Cys Leu Leu Ser Asp Ser Gly Gln 
            340                 345                 350         


Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr Trp Ser Thr Pro 
        355                 360                 365             


Val Gln Pro Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu 
    370                 375                 380                 


Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg 
385                 390                 395                 400 


Arg Arg Gln Ala Glu Arg Met Ser Gln Ile Lys Arg Leu Leu Ser Glu 
                405                 410                 415     


Lys Lys Thr Cys Gln Cys Pro His Arg Phe Gln Lys Thr Cys Ser Pro 
            420                 425                 430         


Ile 
    


<210>  68
<211>  214
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature CD8A(CD8-alpha)

<400>  68

Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr Trp Asn Leu Gly Glu 
1               5                   10                  15      


Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser Asn Pro Thr Ser Gly 
            20                  25                  30          


Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala Ala Ser Pro Thr Phe 
        35                  40                  45              


Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala Ala Glu Gly Leu Asp 
    50                  55                  60                  


Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp Thr Phe Val Leu Thr 
65                  70                  75                  80  


Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr Tyr Phe Cys Ser Ala 
                85                  90                  95      


Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu 
            100                 105                 110         


Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        115                 120                 125             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    130                 135                 140                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
145                 150                 155                 160 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                165                 170                 175     


Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Arg Arg 
            180                 185                 190         


Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser Gly Asp Lys Pro Ser 
        195                 200                 205             


Leu Ser Ala Arg Tyr Val 
    210                 


<210>  69
<211>  189
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature CD8B(CD8-beta)

<400>  69

Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln Thr Asn Lys Met Val 
1               5                   10                  15      


Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser Asn Met Arg Ile Tyr 
            20                  25                  30          


Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp Ser His His Glu Phe 
        35                  40                  45              


Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile His Gly Glu Glu Val 
    50                  55                  60                  


Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala Ser Arg Phe Ile Leu 
65                  70                  75                  80  


Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly Ile Tyr Phe Cys Met 
                85                  90                  95      


Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys Gly Thr Gln Leu Ser 
            100                 105                 110         


Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro Thr Lys Lys Ser Thr 
        115                 120                 125             


Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro Glu Thr Gln Lys Gly 
    130                 135                 140                 


Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu Val Ala Gly Val Leu 
145                 150                 155                 160 


Val Leu Leu Val Ser Leu Gly Val Ala Ile His Leu Cys Cys Arg Arg 
                165                 170                 175     


Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Phe Tyr Lys 
            180                 185                 


<210>  70
<211>  497
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature LAG3

<400>  70

Val Pro Val Val Trp Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys 
1               5                   10                  15      


Ser Pro Thr Ile Pro Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly 
            20                  25                  30          


Val Thr Trp Gln His Gln Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro 
        35                  40                  45              


Gly His Pro Leu Ala Pro Gly Pro His Pro Ala Ala Pro Ser Ser Trp 
    50                  55                  60                  


Gly Pro Arg Pro Arg Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly 
65                  70                  75                  80  


Leu Arg Ser Gly Arg Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu 
                85                  90                  95      


Arg Gly Arg Gln Arg Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg 
            100                 105                 110         


Arg Ala Asp Ala Gly Glu Tyr Arg Ala Ala Val His Leu Arg Asp Arg 
        115                 120                 125             


Ala Leu Ser Cys Arg Leu Arg Leu Arg Leu Gly Gln Ala Ser Met Thr 
    130                 135                 140                 


Ala Ser Pro Pro Gly Ser Leu Arg Ala Ser Asp Trp Val Ile Leu Asn 
145                 150                 155                 160 


Cys Ser Phe Ser Arg Pro Asp Arg Pro Ala Ser Val His Trp Phe Arg 
                165                 170                 175     


Asn Arg Gly Gln Gly Arg Val Pro Val Arg Glu Ser Pro His His His 
            180                 185                 190         


Leu Ala Glu Ser Phe Leu Phe Leu Pro Gln Val Ser Pro Met Asp Ser 
        195                 200                 205             


Gly Pro Trp Gly Cys Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser 
    210                 215                 220                 


Ile Met Tyr Asn Leu Thr Val Leu Gly Leu Glu Pro Pro Thr Pro Leu 
225                 230                 235                 240 


Thr Val Tyr Ala Gly Ala Gly Ser Arg Val Gly Leu Pro Cys Arg Leu 
                245                 250                 255     


Pro Ala Gly Val Gly Thr Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro 
            260                 265                 270         


Pro Gly Gly Gly Pro Asp Leu Leu Val Thr Gly Asp Asn Gly Asp Phe 
        275                 280                 285             


Thr Leu Arg Leu Glu Asp Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr 
    290                 295                 300                 


Cys His Ile His Leu Gln Glu Gln Gln Leu Asn Ala Thr Val Thr Leu 
305                 310                 315                 320 


Ala Ile Ile Thr Val Thr Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu 
                325                 330                 335     


Gly Lys Leu Leu Cys Glu Val Thr Pro Val Ser Gly Gln Glu Arg Phe 
            340                 345                 350         


Val Trp Ser Ser Leu Asp Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro 
        355                 360                 365             


Trp Leu Glu Ala Gln Glu Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys 
    370                 375                 380                 


Gln Leu Tyr Gln Gly Glu Arg Leu Leu Gly Ala Ala Val Tyr Phe Thr 
385                 390                 395                 400 


Glu Leu Ser Ser Pro Gly Ala Gln Arg Ser Gly Arg Ala Pro Gly Ala 
                405                 410                 415     


Leu Pro Ala Gly His Leu Leu Leu Phe Leu Ile Leu Gly Val Leu Ser 
            420                 425                 430         


Leu Leu Leu Leu Val Thr Gly Ala Phe Gly Phe His Leu Trp Arg Arg 
        435                 440                 445             


Gln Trp Arg Pro Arg Arg Phe Ser Ala Leu Glu Gln Gly Ile His Pro 
    450                 455                 460                 


Pro Gln Ala Gln Ser Lys Ile Glu Glu Leu Glu Gln Glu Pro Glu Pro 
465                 470                 475                 480 


Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Gln 
                485                 490                 495     


Leu 
    


<210>  71
<211>  280
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature HAVCR2(TIM-3)

<400>  71

Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln Asn Ala Tyr Leu Pro 
1               5                   10                  15      


Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu Val Pro Val Cys Trp 
            20                  25                  30          


Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly Asn Val Val Leu Arg 
        35                  40                  45              


Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser Arg Tyr Trp Leu Asn 
    50                  55                  60                  


Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr Ile Glu Asn Val Thr 
65                  70                  75                  80  


Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile Gln Ile Pro Gly Ile 
                85                  90                  95      


Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val Ile Lys Pro Ala Lys 
            100                 105                 110         


Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe Thr Ala Ala Phe Pro 
        115                 120                 125             


Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala Glu Thr Gln Thr Leu 
    130                 135                 140                 


Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile Ser Thr Leu Ala Asn 
145                 150                 155                 160 


Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu Arg Asp Ser Gly Ala 
                165                 170                 175     


Thr Ile Arg Ile Gly Ile Tyr Ile Gly Ala Gly Ile Cys Ala Gly Leu 
            180                 185                 190         


Ala Leu Ala Leu Ile Phe Gly Ala Leu Ile Phe Lys Trp Tyr Ser His 
        195                 200                 205             


Ser Lys Glu Lys Ile Gln Asn Leu Ser Leu Ile Ser Leu Ala Asn Leu 
    210                 215                 220                 


Pro Pro Ser Gly Leu Ala Asn Ala Val Ala Glu Gly Ile Arg Ser Glu 
225                 230                 235                 240 


Glu Asn Ile Tyr Thr Ile Glu Glu Asn Val Tyr Glu Val Glu Glu Pro 
                245                 250                 255     


Asn Glu Tyr Tyr Cys Tyr Val Ser Ser Arg Gln Gln Pro Ser Gln Pro 
            260                 265                 270         


Leu Gly Cys Arg Phe Ala Met Pro 
        275                 280 


<210>  72
<211>  492
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature CEACAM1

<400>  72

Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly Lys Glu 
1               5                   10                  15      


Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly Tyr Ser 
            20                  25                  30          


Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val Gly Tyr 
        35                  40                  45              


Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser Gly Arg 
    50                  55                  60                  


Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val Thr Gln 
65                  70                  75                  80  


Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp Leu Val 
                85                  90                  95      


Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu Pro Lys 
            100                 105                 110         


Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys Asp Ala 
        115                 120                 125             


Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr Leu Trp 
    130                 135                 140                 


Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser 
145                 150                 155                 160 


Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn Asp Thr 
                165                 170                 175     


Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn Arg Ser 
            180                 185                 190         


Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro Thr Ile 
        195                 200                 205             


Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser Leu Ser 
    210                 215                 220                 


Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu Ile Asn 
225                 230                 235                 240 


Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn Ile Thr 
                245                 250                 255     


Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser Val Thr 
            260                 265                 270         


Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu Leu Ser 
        275                 280                 285             


Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Thr Thr Val Thr 
    290                 295                 300                 


Gly Asp Lys Asp Ser Val Asn Leu Thr Cys Ser Thr Asn Asp Thr Gly 
305                 310                 315                 320 


Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser Ser Glu 
                325                 330                 335     


Arg Met Lys Leu Ser Gln Gly Asn Thr Thr Leu Ser Ile Asn Pro Val 
            340                 345                 350         


Lys Arg Glu Asp Ala Gly Thr Tyr Trp Cys Glu Val Phe Asn Pro Ile 
        355                 360                 365             


Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr Asn Ala 
    370                 375                 380                 


Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly Ile Val 
385                 390                 395                 400 


Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu Ala Cys 
                405                 410                 415     


Phe Leu His Phe Gly Lys Thr Gly Arg Ala Ser Asp Gln Arg Asp Leu 
            420                 425                 430         


Thr Glu His Lys Pro Ser Val Ser Asn His Thr Gln Asp His Ser Asn 
        435                 440                 445             


Asp Pro Pro Asn Lys Met Asn Glu Val Thr Tyr Ser Thr Leu Asn Phe 
    450                 455                 460                 


Glu Ala Gln Gln Pro Thr Gln Pro Thr Ser Ala Ser Pro Ser Leu Thr 
465                 470                 475                 480 


Ala Thr Glu Ile Ile Tyr Ser Glu Val Lys Lys Gln 
                485                 490         


<210>  73
<211>  222
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature TIGIT

<400>  73

Met Thr Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala Glu Lys Gly 
1               5                   10                  15      


Gly Ser Ile Ile Leu Gln Cys His Leu Ser Ser Thr Thr Ala Gln Val 
            20                  25                  30          


Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala Ile Cys Asn 
        35                  40                  45              


Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys Asp Arg Val Ala 
    50                  55                  60                  


Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr Val Asn Asp 
65                  70                  75                  80  


Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp Gly Thr Tyr 
                85                  90                  95      


Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser Val Ala Glu His 
            100                 105                 110         


Gly Ala Arg Phe Gln Ile Pro Leu Leu Gly Ala Met Ala Ala Thr Leu 
        115                 120                 125             


Val Val Ile Cys Thr Ala Val Ile Val Val Val Ala Leu Thr Arg Lys 
    130                 135                 140                 


Lys Lys Ala Leu Arg Ile His Ser Val Glu Gly Asp Leu Arg Arg Lys 
145                 150                 155                 160 


Ser Ala Gly Gln Glu Glu Trp Ser Pro Ser Ala Pro Ser Pro Pro Gly 
                165                 170                 175     


Ser Cys Val Gln Ala Glu Ala Ala Pro Ala Gly Leu Cys Gly Glu Gln 
            180                 185                 190         


Arg Gly Glu Asp Cys Ala Glu Leu His Asp Tyr Phe Asn Val Leu Ser 
        195                 200                 205             


Tyr Arg Ser Leu Gly Asn Cys Ser Phe Phe Thr Glu Thr Gly 
    210                 215                 220         


<210>  74
<211>  397
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature PVR(CD155)

<400>  74

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn Ala Ile Ile Phe Leu Val Leu Gly Ile Leu Val Phe Leu 
                325                 330                 335     


Ile Leu Leu Gly Ile Gly Ile Tyr Phe Tyr Trp Ser Lys Cys Ser Arg 
            340                 345                 350         


Glu Val Leu Trp His Cys His Leu Cys Pro Ser Ser Thr Glu His Ala 
        355                 360                 365             


Ser Ala Ser Ala Asn Gly His Val Ser Tyr Ser Ala Val Ser Arg Glu 
    370                 375                 380                 


Asn Ser Ser Ser Gln Asp Pro Gln Thr Glu Gly Thr Arg 
385                 390                 395         


<210>  75
<211>  507
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature PVRL2(CD112)

<400>  75

Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly 
1               5                   10                  15      


Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu 
            20                  25                  30          


Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His 
        35                  40                  45              


Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser 
    50                  55                  60                  


Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser 
65                  70                  75                  80  


Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu 
                85                  90                  95      


His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala 
            100                 105                 110         


Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile 
        115                 120                 125             


Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln 
    130                 135                 140                 


Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro 
145                 150                 155                 160 


Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr 
                165                 170                 175     


Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe 
            180                 185                 190         


Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys 
        195                 200                 205             


Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu 
    210                 215                 220                 


Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn 
225                 230                 235                 240 


Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser 
                245                 250                 255     


Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe 
            260                 265                 270         


Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val 
        275                 280                 285             


Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val 
    290                 295                 300                 


Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn 
305                 310                 315                 320 


Thr Ala Gly Ala Gly Ala Thr Gly Gly Ile Ile Gly Gly Ile Ile Ala 
                325                 330                 335     


Ala Ile Ile Ala Thr Ala Val Ala Ala Thr Gly Ile Leu Ile Cys Arg 
            340                 345                 350         


Gln Gln Arg Lys Glu Gln Thr Leu Gln Gly Ala Glu Glu Asp Glu Asp 
        355                 360                 365             


Leu Glu Gly Pro Pro Ser Tyr Lys Pro Pro Thr Pro Lys Ala Lys Leu 
    370                 375                 380                 


Glu Ala Gln Glu Met Pro Ser Gln Leu Phe Thr Leu Gly Ala Ser Glu 
385                 390                 395                 400 


His Ser Pro Leu Lys Thr Pro Tyr Phe Asp Ala Gly Ala Ser Cys Thr 
                405                 410                 415     


Glu Gln Glu Met Pro Arg Tyr His Glu Leu Pro Thr Leu Glu Glu Arg 
            420                 425                 430         


Ser Gly Pro Leu His Pro Gly Ala Thr Ser Leu Gly Ser Pro Ile Pro 
        435                 440                 445             


Val Pro Pro Gly Pro Pro Ala Val Glu Asp Val Ser Leu Asp Leu Glu 
    450                 455                 460                 


Asp Glu Glu Gly Glu Glu Glu Glu Glu Tyr Leu Asp Lys Ile Asn Pro 
465                 470                 475                 480 


Ile Tyr Asp Ala Leu Ser Tyr Ser Ser Pro Ser Asp Ser Tyr Gln Gly 
                485                 490                 495     


Lys Gly Phe Val Met Ser Arg Ala Met Tyr Val 
            500                 505         


<210>  76
<211>  318
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature CD226

<400>  76

Glu Glu Val Leu Trp His Thr Ser Val Pro Phe Ala Glu Asn Met Ser 
1               5                   10                  15      


Leu Glu Cys Val Tyr Pro Ser Met Gly Ile Leu Thr Gln Val Glu Trp 
            20                  25                  30          


Phe Lys Ile Gly Thr Gln Gln Asp Ser Ile Ala Ile Phe Ser Pro Thr 
        35                  40                  45              


His Gly Met Val Ile Arg Lys Pro Tyr Ala Glu Arg Val Tyr Phe Leu 
    50                  55                  60                  


Asn Ser Thr Met Ala Ser Asn Asn Met Thr Leu Phe Phe Arg Asn Ala 
65                  70                  75                  80  


Ser Glu Asp Asp Val Gly Tyr Tyr Ser Cys Ser Leu Tyr Thr Tyr Pro 
                85                  90                  95      


Gln Gly Thr Trp Gln Lys Val Ile Gln Val Val Gln Ser Asp Ser Phe 
            100                 105                 110         


Glu Ala Ala Val Pro Ser Asn Ser His Ile Val Ser Glu Pro Gly Lys 
        115                 120                 125             


Asn Val Thr Leu Thr Cys Gln Pro Gln Met Thr Trp Pro Val Gln Ala 
    130                 135                 140                 


Val Arg Trp Glu Lys Ile Gln Pro Arg Gln Ile Asp Leu Leu Thr Tyr 
145                 150                 155                 160 


Cys Asn Leu Val His Gly Arg Asn Phe Thr Ser Lys Phe Pro Arg Gln 
                165                 170                 175     


Ile Val Ser Asn Cys Ser His Gly Arg Trp Ser Val Ile Val Ile Pro 
            180                 185                 190         


Asp Val Thr Val Ser Asp Ser Gly Leu Tyr Arg Cys Tyr Leu Gln Ala 
        195                 200                 205             


Ser Ala Gly Glu Asn Glu Thr Phe Val Met Arg Leu Thr Val Ala Glu 
    210                 215                 220                 


Gly Lys Thr Asp Asn Gln Tyr Thr Leu Phe Val Ala Gly Gly Thr Val 
225                 230                 235                 240 


Leu Leu Leu Leu Phe Val Ile Ser Ile Thr Thr Ile Ile Val Ile Phe 
                245                 250                 255     


Leu Asn Arg Arg Arg Arg Arg Glu Arg Arg Asp Leu Phe Thr Glu Ser 
            260                 265                 270         


Trp Asp Thr Gln Lys Ala Pro Asn Asn Tyr Arg Ser Pro Ile Ser Thr 
        275                 280                 285             


Ser Gln Pro Thr Asn Gln Ser Met Asp Asp Thr Arg Glu Asp Ile Tyr 
    290                 295                 300                 


Val Asn Tyr Pro Thr Phe Ser Arg Arg Pro Lys Thr Arg Val 
305                 310                 315             


<210>  77
<211>  327
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature CD2

<400>  77

Lys Glu Ile Thr Asn Ala Leu Glu Thr Trp Gly Ala Leu Gly Gln Asp 
1               5                   10                  15      


Ile Asn Leu Asp Ile Pro Ser Phe Gln Met Ser Asp Asp Ile Asp Asp 
            20                  25                  30          


Ile Lys Trp Glu Lys Thr Ser Asp Lys Lys Lys Ile Ala Gln Phe Arg 
        35                  40                  45              


Lys Glu Lys Glu Thr Phe Lys Glu Lys Asp Thr Tyr Lys Leu Phe Lys 
    50                  55                  60                  


Asn Gly Thr Leu Lys Ile Lys His Leu Lys Thr Asp Asp Gln Asp Ile 
65                  70                  75                  80  


Tyr Lys Val Ser Ile Tyr Asp Thr Lys Gly Lys Asn Val Leu Glu Lys 
                85                  90                  95      


Ile Phe Asp Leu Lys Ile Gln Glu Arg Val Ser Lys Pro Lys Ile Ser 
            100                 105                 110         


Trp Thr Cys Ile Asn Thr Thr Leu Thr Cys Glu Val Met Asn Gly Thr 
        115                 120                 125             


Asp Pro Glu Leu Asn Leu Tyr Gln Asp Gly Lys His Leu Lys Leu Ser 
    130                 135                 140                 


Gln Arg Val Ile Thr His Lys Trp Thr Thr Ser Leu Ser Ala Lys Phe 
145                 150                 155                 160 


Lys Cys Thr Ala Gly Asn Lys Val Ser Lys Glu Ser Ser Val Glu Pro 
                165                 170                 175     


Val Ser Cys Pro Glu Lys Gly Leu Asp Ile Tyr Leu Ile Ile Gly Ile 
            180                 185                 190         


Cys Gly Gly Gly Ser Leu Leu Met Val Phe Val Ala Leu Leu Val Phe 
        195                 200                 205             


Tyr Ile Thr Lys Arg Lys Lys Gln Arg Ser Arg Arg Asn Asp Glu Glu 
    210                 215                 220                 


Leu Glu Thr Arg Ala His Arg Val Ala Thr Glu Glu Arg Gly Arg Lys 
225                 230                 235                 240 


Pro His Gln Ile Pro Ala Ser Thr Pro Gln Asn Pro Ala Thr Ser Gln 
                245                 250                 255     


His Pro Pro Pro Pro Pro Gly His Arg Ser Gln Ala Pro Ser His Arg 
            260                 265                 270         


Pro Pro Pro Pro Gly His Arg Val Gln His Gln Pro Gln Lys Arg Pro 
        275                 280                 285             


Pro Ala Pro Ser Gly Thr Gln Val His Gln Gln Lys Gly Pro Pro Leu 
    290                 295                 300                 


Pro Arg Pro Arg Val Gln Pro Lys Pro Pro His Gly Ala Ala Glu Asn 
305                 310                 315                 320 


Ser Leu Ser Pro Ser Ser Asn 
                325         


<210>  78
<211>  154
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature CD160

<400>  78

Ile Asn Ile Thr Ser Ser Ala Ser Gln Glu Gly Thr Arg Leu Asn Leu 
1               5                   10                  15      


Ile Cys Thr Val Trp His Lys Lys Glu Glu Ala Glu Gly Phe Val Val 
            20                  25                  30          


Phe Leu Cys Lys Asp Arg Ser Gly Asp Cys Ser Pro Glu Thr Ser Leu 
        35                  40                  45              


Lys Gln Leu Arg Leu Lys Arg Asp Pro Gly Ile Asp Gly Val Gly Glu 
    50                  55                  60                  


Ile Ser Ser Gln Leu Met Phe Thr Ile Ser Gln Val Thr Pro Leu His 
65                  70                  75                  80  


Ser Gly Thr Tyr Gln Cys Cys Ala Arg Ser Gln Lys Ser Gly Ile Arg 
                85                  90                  95      


Leu Gln Gly His Phe Phe Ser Ile Leu Phe Thr Glu Thr Gly Asn Tyr 
            100                 105                 110         


Thr Val Thr Gly Leu Lys Gln Arg Gln His Leu Glu Phe Ser His Asn 
        115                 120                 125             


Glu Gly Thr Leu Ser Ser Gly Phe Leu Gln Glu Lys Val Trp Val Met 
    130                 135                 140                 


Leu Val Thr Ser Leu Val Ala Leu Gln Ala 
145                 150                 


<210>  79
<211>  248
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature CD200

<400>  79

Gln Val Gln Val Val Thr Gln Asp Glu Arg Glu Gln Leu Tyr Thr Pro 
1               5                   10                  15      


Ala Ser Leu Lys Cys Ser Leu Gln Asn Ala Gln Glu Ala Leu Ile Val 
            20                  25                  30          


Thr Trp Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr Phe 
        35                  40                  45              


Ser Glu Asn His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Lys Ile 
    50                  55                  60                  


Asn Ile Thr Gln Leu Gly Leu Gln Asn Ser Thr Ile Thr Phe Trp Asn 
65                  70                  75                  80  


Ile Thr Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe 
                85                  90                  95      


Gly Phe Gly Lys Ile Ser Gly Thr Ala Cys Leu Thr Val Tyr Val Gln 
            100                 105                 110         


Pro Ile Val Ser Leu His Tyr Lys Phe Ser Glu Asp His Leu Asn Ile 
        115                 120                 125             


Thr Cys Ser Ala Thr Ala Arg Pro Ala Pro Met Val Phe Trp Lys Val 
    130                 135                 140                 


Pro Arg Ser Gly Ile Glu Asn Ser Thr Val Thr Leu Ser His Pro Asn 
145                 150                 155                 160 


Gly Thr Thr Ser Val Thr Ser Ile Leu His Ile Lys Asp Pro Lys Asn 
                165                 170                 175     


Gln Val Gly Lys Glu Val Ile Cys Gln Val Leu His Leu Gly Thr Val 
            180                 185                 190         


Thr Asp Phe Lys Gln Thr Val Asn Lys Gly Tyr Trp Phe Ser Val Pro 
        195                 200                 205             


Leu Leu Leu Ser Ile Val Ser Leu Val Ile Leu Leu Val Leu Ile Ser 
    210                 215                 220                 


Ile Leu Leu Tyr Trp Lys Arg His Arg Asn Gln Asp Arg Gly Glu Leu 
225                 230                 235                 240 


Ser Gln Gly Val Gln Lys Met Thr 
                245             


<210>  80
<211>  297
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature CD200R1(CD200R)

<400>  80

Met Asp Glu Lys Gln Ile Thr Gln Asn Tyr Ser Lys Val Leu Ala Glu 
1               5                   10                  15      


Val Asn Thr Ser Trp Pro Val Lys Met Ala Thr Asn Ala Val Leu Cys 
            20                  25                  30          


Cys Pro Pro Ile Ala Leu Arg Asn Leu Ile Ile Ile Thr Trp Glu Ile 
        35                  40                  45              


Ile Leu Arg Gly Gln Pro Ser Cys Thr Lys Ala Tyr Arg Lys Glu Thr 
    50                  55                  60                  


Asn Glu Thr Lys Glu Thr Asn Cys Thr Asp Glu Arg Ile Thr Trp Val 
65                  70                  75                  80  


Ser Arg Pro Asp Gln Asn Ser Asp Leu Gln Ile Arg Pro Val Ala Ile 
                85                  90                  95      


Thr His Asp Gly Tyr Tyr Arg Cys Ile Met Val Thr Pro Asp Gly Asn 
            100                 105                 110         


Phe His Arg Gly Tyr His Leu Gln Val Leu Val Thr Pro Glu Val Thr 
        115                 120                 125             


Leu Phe Gln Asn Arg Asn Arg Thr Ala Val Cys Lys Ala Val Ala Gly 
    130                 135                 140                 


Lys Pro Ala Ala Gln Ile Ser Trp Ile Pro Glu Gly Asp Cys Ala Thr 
145                 150                 155                 160 


Lys Gln Glu Tyr Trp Ser Asn Gly Thr Val Thr Val Lys Ser Thr Cys 
                165                 170                 175     


His Trp Glu Val His Asn Val Ser Thr Val Thr Cys His Val Ser His 
            180                 185                 190         


Leu Thr Gly Asn Lys Ser Leu Tyr Ile Glu Leu Leu Pro Val Pro Gly 
        195                 200                 205             


Ala Lys Lys Ser Ala Lys Leu Tyr Ile Pro Tyr Ile Ile Leu Thr Ile 
    210                 215                 220                 


Ile Ile Leu Thr Ile Val Gly Phe Ile Trp Leu Leu Lys Val Asn Gly 
225                 230                 235                 240 


Cys Arg Lys Tyr Lys Leu Asn Lys Thr Glu Ser Thr Pro Val Val Glu 
                245                 250                 255     


Glu Asp Glu Met Gln Pro Tyr Ala Ser Tyr Thr Glu Lys Asn Asn Pro 
            260                 265                 270         


Leu Tyr Asp Thr Thr Asn Lys Val Lys Ala Ser Glu Ala Leu Gln Ser 
        275                 280                 285             


Glu Val Asp Thr Asp Leu His Thr Leu 
    290                 295         


<210>  81
<211>  183
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature NC R3 (NKp30)

<400>  81

Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser 
1               5                   10                  15      


Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu Ala Ile 
            20                  25                  30          


Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val 
        35                  40                  45              


Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu Ala Ser 
    50                  55                  60                  


Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val 
65                  70                  75                  80  


Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val Leu Gly 
                85                  90                  95      


Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu Lys Glu 
            100                 105                 110         


His Pro Gln Leu Gly Ala Gly Thr Val Leu Leu Leu Arg Ala Gly Phe 
        115                 120                 125             


Tyr Ala Val Ser Phe Leu Ser Val Ala Val Gly Ser Thr Val Tyr Tyr 
    130                 135                 140                 


Gln Gly Lys Cys Leu Thr Trp Lys Gly Pro Arg Arg Gln Leu Pro Ala 
145                 150                 155                 160 


Val Val Pro Ala Pro Leu Pro Pro Pro Cys Gly Ser Ser Ala His Leu 
                165                 170                 175     


Leu Pro Pro Val Pro Gly Gly 
            180             


<210>  82
<211>  414
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  VSIG8

<400>  82

Met Arg Val Gly Gly Ala Phe His Leu Leu Leu Val Cys Leu Ser Pro 
1               5                   10                  15      


Ala Leu Leu Ser Ala Val Arg Ile Asn Gly Asp Gly Gln Glu Val Leu 
            20                  25                  30          


Tyr Leu Ala Glu Gly Asp Asn Val Arg Leu Gly Cys Pro Tyr Val Leu 
        35                  40                  45              


Asp Pro Glu Asp Tyr Gly Pro Asn Gly Leu Asp Ile Glu Trp Met Gln 
    50                  55                  60                  


Val Asn Ser Asp Pro Ala His His Arg Glu Asn Val Phe Leu Ser Tyr 
65                  70                  75                  80  


Gln Asp Lys Arg Ile Asn His Gly Ser Leu Pro His Leu Gln Gln Arg 
                85                  90                  95      


Val Arg Phe Ala Ala Ser Asp Pro Ser Gln Tyr Asp Ala Ser Ile Asn 
            100                 105                 110         


Leu Met Asn Leu Gln Val Ser Asp Thr Ala Thr Tyr Glu Cys Arg Val 
        115                 120                 125             


Lys Lys Thr Thr Met Ala Thr Arg Lys Val Ile Val Thr Val Gln Ala 
    130                 135                 140                 


Arg Pro Ala Val Pro Met Cys Trp Thr Glu Gly His Met Thr Tyr Gly 
145                 150                 155                 160 


Asn Asp Val Val Leu Lys Cys Tyr Ala Ser Gly Gly Ser Gln Pro Leu 
                165                 170                 175     


Ser Tyr Lys Trp Ala Lys Ile Ser Gly His His Tyr Pro Tyr Arg Ala 
            180                 185                 190         


Gly Ser Tyr Thr Ser Gln His Ser Tyr His Ser Glu Leu Ser Tyr Gln 
        195                 200                 205             


Glu Ser Phe His Ser Ser Ile Asn Gln Gly Leu Asn Asn Gly Asp Leu 
    210                 215                 220                 


Val Leu Lys Asp Ile Ser Arg Ala Asp Asp Gly Leu Tyr Gln Cys Thr 
225                 230                 235                 240 


Val Ala Asn Asn Val Gly Tyr Ser Val Cys Val Val Glu Val Lys Val 
                245                 250                 255     


Ser Asp Ser Arg Arg Ile Gly Val Ile Ile Gly Ile Val Leu Gly Ser 
            260                 265                 270         


Leu Leu Ala Leu Gly Cys Leu Ala Val Gly Ile Trp Gly Leu Val Cys 
        275                 280                 285             


Cys Cys Cys Gly Gly Ser Gly Ala Gly Gly Ala Arg Gly Ala Phe Gly 
    290                 295                 300                 


Tyr Gly Asn Gly Gly Gly Val Gly Gly Gly Ala Cys Gly Asp Leu Ala 
305                 310                 315                 320 


Ser Glu Ile Arg Glu Asp Ala Val Ala Pro Gly Cys Lys Ala Ser Gly 
                325                 330                 335     


Arg Gly Ser Arg Val Thr His Leu Leu Gly Tyr Pro Thr Gln Asn Val 
            340                 345                 350         


Ser Arg Ser Leu Arg Arg Lys Tyr Ala Pro Pro Pro Cys Gly Gly Pro 
        355                 360                 365             


Glu Asp Val Ala Leu Ala Pro Cys Thr Ala Ala Ala Ala Cys Glu Ala 
    370                 375                 380                 


Gly Pro Ser Pro Val Tyr Val Lys Val Lys Ser Ala Glu Pro Ala Asp 
385                 390                 395                 400 


Cys Ala Glu Gly Pro Val Gln Cys Lys Asn Gly Leu Leu Val 
                405                 410                 


<210>  83
<211>  393
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Mature VSIG8

<400>  83

Val Arg Ile Asn Gly Asp Gly Gln Glu Val Leu Tyr Leu Ala Glu Gly 
1               5                   10                  15      


Asp Asn Val Arg Leu Gly Cys Pro Tyr Val Leu Asp Pro Glu Asp Tyr 
            20                  25                  30          


Gly Pro Asn Gly Leu Asp Ile Glu Trp Met Gln Val Asn Ser Asp Pro 
        35                  40                  45              


Ala His His Arg Glu Asn Val Phe Leu Ser Tyr Gln Asp Lys Arg Ile 
    50                  55                  60                  


Asn His Gly Ser Leu Pro His Leu Gln Gln Arg Val Arg Phe Ala Ala 
65                  70                  75                  80  


Ser Asp Pro Ser Gln Tyr Asp Ala Ser Ile Asn Leu Met Asn Leu Gln 
                85                  90                  95      


Val Ser Asp Thr Ala Thr Tyr Glu Cys Arg Val Lys Lys Thr Thr Met 
            100                 105                 110         


Ala Thr Arg Lys Val Ile Val Thr Val Gln Ala Arg Pro Ala Val Pro 
        115                 120                 125             


Met Cys Trp Thr Glu Gly His Met Thr Tyr Gly Asn Asp Val Val Leu 
    130                 135                 140                 


Lys Cys Tyr Ala Ser Gly Gly Ser Gln Pro Leu Ser Tyr Lys Trp Ala 
145                 150                 155                 160 


Lys Ile Ser Gly His His Tyr Pro Tyr Arg Ala Gly Ser Tyr Thr Ser 
                165                 170                 175     


Gln His Ser Tyr His Ser Glu Leu Ser Tyr Gln Glu Ser Phe His Ser 
            180                 185                 190         


Ser Ile Asn Gln Gly Leu Asn Asn Gly Asp Leu Val Leu Lys Asp Ile 
        195                 200                 205             


Ser Arg Ala Asp Asp Gly Leu Tyr Gln Cys Thr Val Ala Asn Asn Val 
    210                 215                 220                 


Gly Tyr Ser Val Cys Val Val Glu Val Lys Val Ser Asp Ser Arg Arg 
225                 230                 235                 240 


Ile Gly Val Ile Ile Gly Ile Val Leu Gly Ser Leu Leu Ala Leu Gly 
                245                 250                 255     


Cys Leu Ala Val Gly Ile Trp Gly Leu Val Cys Cys Cys Cys Gly Gly 
            260                 265                 270         


Ser Gly Ala Gly Gly Ala Arg Gly Ala Phe Gly Tyr Gly Asn Gly Gly 
        275                 280                 285             


Gly Val Gly Gly Gly Ala Cys Gly Asp Leu Ala Ser Glu Ile Arg Glu 
    290                 295                 300                 


Asp Ala Val Ala Pro Gly Cys Lys Ala Ser Gly Arg Gly Ser Arg Val 
305                 310                 315                 320 


Thr His Leu Leu Gly Tyr Pro Thr Gln Asn Val Ser Arg Ser Leu Arg 
                325                 330                 335     


Arg Lys Tyr Ala Pro Pro Pro Cys Gly Gly Pro Glu Asp Val Ala Leu 
            340                 345                 350         


Ala Pro Cys Thr Ala Ala Ala Ala Cys Glu Ala Gly Pro Ser Pro Val 
        355                 360                 365             


Tyr Val Lys Val Lys Ser Ala Glu Pro Ala Asp Cys Ala Glu Gly Pro 
    370                 375                 380                 


Val Gln Cys Lys Asn Gly Leu Leu Val 
385                 390             


<210>  84
<211>  242
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  VSIG8 ECD

<400>  84

Val Arg Ile Asn Gly Asp Gly Gln Glu Val Leu Tyr Leu Ala Glu Gly 
1               5                   10                  15      


Asp Asn Val Arg Leu Gly Cys Pro Tyr Val Leu Asp Pro Glu Asp Tyr 
            20                  25                  30          


Gly Pro Asn Gly Leu Asp Ile Glu Trp Met Gln Val Asn Ser Asp Pro 
        35                  40                  45              


Ala His His Arg Glu Asn Val Phe Leu Ser Tyr Gln Asp Lys Arg Ile 
    50                  55                  60                  


Asn His Gly Ser Leu Pro His Leu Gln Gln Arg Val Arg Phe Ala Ala 
65                  70                  75                  80  


Ser Asp Pro Ser Gln Tyr Asp Ala Ser Ile Asn Leu Met Asn Leu Gln 
                85                  90                  95      


Val Ser Asp Thr Ala Thr Tyr Glu Cys Arg Val Lys Lys Thr Thr Met 
            100                 105                 110         


Ala Thr Arg Lys Val Ile Val Thr Val Gln Ala Arg Pro Ala Val Pro 
        115                 120                 125             


Met Cys Trp Thr Glu Gly His Met Thr Tyr Gly Asn Asp Val Val Leu 
    130                 135                 140                 


Lys Cys Tyr Ala Ser Gly Gly Ser Gln Pro Leu Ser Tyr Lys Trp Ala 
145                 150                 155                 160 


Lys Ile Ser Gly His His Tyr Pro Tyr Arg Ala Gly Ser Tyr Thr Ser 
                165                 170                 175     


Gln His Ser Tyr His Ser Glu Leu Ser Tyr Gln Glu Ser Phe His Ser 
            180                 185                 190         


Ser Ile Asn Gln Gly Leu Asn Asn Gly Asp Leu Val Leu Lys Asp Ile 
        195                 200                 205             


Ser Arg Ala Asp Asp Gly Leu Tyr Gln Cys Thr Val Ala Asn Asn Val 
    210                 215                 220                 


Gly Tyr Ser Val Cys Val Val Glu Val Lys Val Ser Asp Ser Arg Arg 
225                 230                 235                 240 


Ile Gly 
        


<210>  85
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSA signal peptide

<400>  85

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  86
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ig kappa light chain

<400>  86

Met Asp Met Arg Ala Pro Ala Gly Ile Phe Gly Phe Leu Leu Val Leu 
1               5                   10                  15      


Phe Pro Gly Tyr Arg Ser 
            20          


<210>  87
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human azurocidin preprotein signal sequence

<400>  87

Met Thr Arg Leu Thr Val Leu Ala Leu Leu Ala Gly Leu Leu Ala Ser 
1               5                   10                  15      


Ser Arg Ala 
            


<210>  88
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG heavy chain signal peptide

<400>  88

Met Glu Leu Gly Leu Ser Trp Ile Phe Leu Leu Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  89
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG heavy chain signal peptide

<400>  89

Met Glu Leu Gly Leu Arg Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  90
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG heavy chain signal peptide

<400>  90

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser 
            


<210>  91
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG heavy chain signal peptide

<400>  91

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser 
            


<210>  92
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG heavy chain signal peptide

<400>  92

Met Asp Trp Thr Trp Arg Phe Leu Phe Val Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Val Gln Ser 
            


<210>  93
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG heavy chain signal peptide

<400>  93

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  94
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG heavy chain signal peptide

<400>  94

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  95
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG heavy chain signal peptide

<400>  95

Met Asp Leu Leu His Lys Asn Met Lys His Leu Trp Phe Phe Leu Leu 
1               5                   10                  15      


Leu Val Ala Ala Pro Arg Trp Val Leu Ser 
            20                  25      


<210>  96
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG Kappa light chain signal sequences

<400>  96

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ser Gly Ala Arg Cys 
            20          


<210>  97
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG Kappa light chain signal sequences

<400>  97

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala 
            20          


<210>  98
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gaussia luciferase

<400>  98

Met Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val Ala Glu 
1               5                   10                  15      


Ala 
    


<210>  99
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human albumin

<400>  99

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  100
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human chymotrypsinogen

<400>  100

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly 
        


<210>  101
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human interleukin-2

<400>  101

Met Gln Leu Leu Ser Cys Ile Ala Leu Ile Leu Ala Leu Val 
1               5                   10                  


<210>  102
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human trypsinogen-2

<400>  102

Met Asn Leu Leu Leu Ile Leu Thr Phe Val Ala Ala Ala Val Ala 
1               5                   10                  15  


<210>  103
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v1 (1-150)

<400>  103

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  104
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v2 (1-150)

<400>  104

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Ser Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Ala Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  105
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v3 (1-150)

<400>  105

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Tyr Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asp Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Ser Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  106
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v4 (1-150)

<400>  106

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Val Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Gln 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ser Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  107
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v5 (1-150)

<400>  107

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  108
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v6 (1-150)

<400>  108

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly His Asp Phe Leu Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  109
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v7 (1-150)

<400>  109

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Arg Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Ile Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Ser Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  110
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v8 (1-150)

<400>  110

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Glu Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  111
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v9 (1-150)

<400>  111

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Val Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp His Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala Tyr Pro Ser Thr Ser Pro Arg Leu Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  112
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v10 (1-150)

<400>  112

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  113
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v11 (1-150)

<400>  113

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Gly Asn Arg Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Glu Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Thr Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  114
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v12 (1-150)

<400>  114

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala Arg Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  115
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v13 (1-150)

<400>  115

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Ile Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  116
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v14 (1-150)

<400>  116

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Ala Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  117
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v15 (1-150)

<400>  117

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Glu Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  118
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v16 (1-150)

<400>  118

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Thr Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Gln Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Met Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  119
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v17 (1-150)

<400>  119

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Leu Thr Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala Asn Pro Ser Ser Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  120
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v18 (1-150)

<400>  120

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Ile Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  121
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v19 (1-150)

<400>  121

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Ile Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  122
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v20 (1-150)

<400>  122

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Val Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  123
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v21 (1-150)

<400>  123

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Gly Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  124
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v22 (1-150)

<400>  124

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asp 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Ser Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  125
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v23 (1-150)

<400>  125

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Ile Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  126
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v24 (1-150)

<400>  126

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Pro Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Arg Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  127
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v25 (1-150)

<400>  127

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Met Val 
            100                 105                 110         


Gln Ile Glu Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val His Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  128
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v26 (1-150)

<400>  128

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Gly Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Ile Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Ser Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  129
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v27 (1-150)

<400>  129

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  130
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v28 (1-150)

<400>  130

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Pro Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  131
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v29 (1-150)

<400>  131

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Leu Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Pro Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  132
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v30 (1-150)

<400>  132

Pro Gly Trp Phe Leu Asp Ser Pro Gly Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  133
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v31 (1-150)

<400>  133

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Ser Phe 
            20                  25                  30          


Thr Cys Ser Phe Thr Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Ile Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ser Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  134
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v32 (1-150)

<400>  134

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Thr Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Ile Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  135
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v33 (1-150)

<400>  135

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Gly Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  136
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v34 (1-150)

<400>  136

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Asp 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  137
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v35 (1-150)

<400>  137

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe Arg Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  138
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v36 (1-150)

<400>  138

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asp Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Val Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Asp His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  139
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v37 (1-150)

<400>  139

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Cys Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  140
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v38 (1-150)

<400>  140

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Ile 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Ile Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  141
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v39 (1-150)

<400>  141

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Gln Val Glu Leu Arg Val Ile Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala Arg Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  142
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v40 (1-150)

<400>  142

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Val Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  143
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v41 (1-150)

<400>  143

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  144
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v42 (1-150)

<400>  144

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  145
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v43 (1-150)

<400>  145

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Tyr Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Ala Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  146
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v44 (1-150)

<400>  146

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Tyr Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Leu Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  147
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v45 (1-150)

<400>  147

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Tyr Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  148
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v46 (1-150)

<400>  148

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  149
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v47 (1-150)

<400>  149

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Met Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe His Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Thr Thr Ala His Pro Ser Pro Ser Pro Trp Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  150
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v48 (1-150)

<400>  150

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Asp Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Leu Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Ile Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Met Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  151
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v49 (1-150)

<400>  151

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Leu Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Ser Phe 
            20                  25                  30          


Thr Cys Asn Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Ser Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Ser 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  152
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v50 (1-150)

<400>  152

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Leu Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  153
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v51 (1-150)

<400>  153

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Leu Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asp Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Gln Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Thr Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  154
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v52 (1-150)

<400>  154

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln His Gly Gln Asp Arg Arg Phe Arg Val Thr Pro Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Asp Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Thr Ser Pro Ser Pro Arg Pro Asp Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  155
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v53 (1-150)

<400>  155

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Arg Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Ile Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  156
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v54 (1-150)

<400>  156

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Tyr Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Val Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Gly Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Thr Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  157
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v55 (1-150)

<400>  157

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Leu Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Met Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Arg Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  158
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v56 (1-150)

<400>  158

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Leu Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Tyr Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Cys Arg Tyr Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Asp Arg Ala Arg Leu Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Met Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  159
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v57 (1-150)

<400>  159

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Leu Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Thr Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Ser Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu His Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Glu Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Val Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  160
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v58 (1-150)

<400>  160

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asp Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Cys Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  161
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v59 (1-150)

<400>  161

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Val Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Val Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Val Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Ser Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Gln Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Ala Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  162
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v60 (1-150)

<400>  162

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Ile Ser Pro Ala Leu Leu Val Val Ala Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Val Ser Pro Thr Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Ser Arg Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Val Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  163
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v61 (1-150)

<400>  163

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asp Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Leu Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  164
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v62 (1-150)

<400>  164

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Ala Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Gln Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Ala Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  165
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v63 (1-150)

<400>  165

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Tyr Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Leu Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Pro Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Gly Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  166
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v64 (1-150)

<400>  166

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Leu Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Leu Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Gln Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Leu Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  167
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v65 (1-150)

<400>  167

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Ser Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Ser 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  168
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v66 (1-150)

<400>  168

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Arg Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  169
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v67 (1-150)

<400>  169

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Ser Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  170
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v68 (1-150)

<400>  170

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ser Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Gln Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Gln Val Glu Leu Arg Val Ile Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Ser Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  171
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v69 (1-150)

<400>  171

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asp Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Leu Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Gln Val Glu Leu Arg Val Ile Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  172
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v70 (1-150)

<400>  172

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Thr 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  173
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v71 (1-150)

<400>  173

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Val Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Leu Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ser Glu Ala Pro Thr Ala His Pro Ser Pro Ser Pro Gly Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  174
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v72 (1-150)

<400>  174

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Ser Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Arg Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Ala Ser Asn Gln Met Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Ile Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Ala Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  175
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v73 (1-150)

<400>  175

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Leu Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Ala Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  176
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v74 (1-150)

<400>  176

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Val Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Leu Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  177
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v75 (1-150)

<400>  177

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Met Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Leu Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Ile Glu Arg Arg 
        115                 120                 125             


Ala Glu Ala Pro Thr Ala His Pro Ser Pro Ser Pro Trp Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  178
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v76 (1-150)

<400>  178

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Ile Ser Pro Val Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Gly Pro Ser Asp Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Ile Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  179
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v77 (1-150)

<400>  179

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Asn Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Met Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Gln Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Ala Ala His Pro Ser Pro Ser Leu Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  180
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v78 (1-150)

<400>  180

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Val Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Gly Ala Arg Leu Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  181
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v79 (1-150)

<400>  181

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Gly Asn Pro Pro Thr 
1               5                   10                  15      


Leu Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Val Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Glu Pro Thr Ala His Pro Ser Pro Ser Pro Ser Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  182
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v80 (1-150)

<400>  182

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Gly Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Lys Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Ser Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  183
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v81 (1-150)

<400>  183

Pro Gly Trp Phe Leu Asp Ser Thr Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Thr Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  184
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v82 (1-150)

<400>  184

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Asp 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  185
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v83 (1-150)

<400>  185

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Ile Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ile Gln Pro Ser Arg Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Ile Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Ser Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  186
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v84 (1-150)

<400>  186

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  187
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v85 (1-150)

<400>  187

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Ser 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  188
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v86 (1-150)

<400>  188

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asp Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Ile Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Ser Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  189
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v87 (1-150)

<400>  189

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Asp Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Arg Thr Ala His Pro Ser Pro Ser Pro Gly Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  190
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v88 (1-150)

<400>  190

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Ile Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Arg Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Cys Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  191
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v89 (1-150)

<400>  191

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  192
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v90 (1-150)

<400>  192

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Ile Ser Pro Ala Leu Leu Val Leu Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  193
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v91 (1-150)

<400>  193

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Val Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  194
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v92 (1-150)

<400>  194

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asp Pro Pro Thr 
1               5                   10                  15      


Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Met Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  195
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v93 (1-150)

<400>  195

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Ser Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  196
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v94 (1-150)

<400>  196

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Arg Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Val Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp His Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Leu Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  197
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v95 (1-150)

<400>  197

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Leu Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Ile Gly Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Met Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Glu Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  198
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v96 (1-150)

<400>  198

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Val Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Val Glu Leu Arg Val Ile Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Gly Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  199
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v97 (1-150)

<400>  199

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Gly Pro Lys Val 
            100                 105                 110         


Gln Ile Glu Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  200
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v98 (1-150)

<400>  200

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Arg Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe His Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Ile Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  201
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v99 (1-150)

<400>  201

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Arg Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Leu Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Pro Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Arg Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  202
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v100 (1-150)

<400>  202

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Tyr Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  203
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v101 (1-150)

<400>  203

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Ser Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  204
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v102 (1-150)

<400>  204

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Leu Asn Ser Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Val Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Arg Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Val Gln Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Thr Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  205
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v103 (1-150)

<400>  205

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Leu Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Arg Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Leu Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Val Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  206
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v104 (1-150)

<400>  206

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Met Ala Ala Phe Pro Lys 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Gln Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Ile Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Ser Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  207
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v105 (1-150)

<400>  207

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn His Pro Thr 
1               5                   10                  15      


Tyr Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Arg Thr Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Arg Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Asp Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Val Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Arg Thr Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Val Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  208
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v106 (1-150)

<400>  208

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Val Lys Met Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Ser Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Val His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  209
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v107 (1-150)

<400>  209

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Glu Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Ser Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Tyr Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Ala Asn Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Phe Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  210
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v108 (1-150)

<400>  210

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Ala 
1               5                   10                  15      


Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Leu Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe Leu Met Ser Val Val Gly Ala Arg Leu Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  211
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v109 (1-150)

<400>  211

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Val Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Ala Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  212
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v110 (1-150)

<400>  212

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Ser Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Val Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp His Ser Gln Pro Ser Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Ile Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Ser 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  213
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v111 (1-150)

<400>  213

Pro Gly Trp Phe Leu Asp Ser Thr Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Asn Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Leu Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Ile Glu Arg Met 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Thr Ser Pro Gly Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  214
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v112 (1-150)

<400>  214

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Thr Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Met Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asn Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Gly Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala Tyr Pro Ser Pro Ser Pro Arg Pro Ser Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  215
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v113 (1-150)

<400>  215

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Val Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Gln Ala Glu Leu Arg Val Thr Glu Ser Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala Arg Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  216
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v114 (1-150)

<400>  216

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  217
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v115 (1-150)

<400>  217

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Val Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  218
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v116 (1-150)

<400>  218

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Val Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  219
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v117 (1-150)

<400>  219

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  220
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v118 (1-150)

<400>  220

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asp Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln His Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Val Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Ser Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  221
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v119 (1-150)

<400>  221

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asp Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  222
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v120 (1-150)

<400>  222

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asp Pro Pro Thr 
1               5                   10                  15      


Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Met Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Ser Asn Gln Pro Cys Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Ser Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  223
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v121 (1-150)

<400>  223

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Leu Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Ser Asn Gln Pro Cys Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  224
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v122 (1-150)

<400>  224

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Gly Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Thr Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  225
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v123 (1-150)

<400>  225

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Arg Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Ile Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Tyr Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ile Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Val Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Gln Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  226
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v124 (1-150)

<400>  226

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ile Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Gly Val Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Ser Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  227
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v125 (1-150)

<400>  227

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Ile Ser Pro Ala Leu Leu Val Val Ala Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Tyr Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Ile Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  228
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v126 (1-150)

<400>  228

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ile Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Lys Val Pro Thr Ala His Leu Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  229
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v127 (1-150)

<400>  229

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Arg Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Val Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Ser Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  230
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v128 (1-150)

<400>  230

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ile Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Gly Val Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Ser Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  231
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v129 (1-150)

<400>  231

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ile Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Ser Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  232
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v130 (1-150)

<400>  232

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Gly Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Pro Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ile Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Gly Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Asp Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  233
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v131 (1-150)

<400>  233

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ile Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Gly Val Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Ile Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  234
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v132 (1-150)

<400>  234

Pro Gly Trp Phe Leu Asp Ser Pro Val Arg Ala Trp Asp Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Thr Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Met Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Leu Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  235
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v133 (1-150)

<400>  235

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Ile Ser Pro Ala Leu Leu Val Val Ala Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Tyr Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  236
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v134 (1-150)

<400>  236

Pro Gly Trp Phe Leu Asp Ser Pro Glu Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ile Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Met Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Ala Tyr Leu Cys Ala Ala Ile Ser Leu Ala Pro Met Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Asp Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  237
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v135 (1-150)

<400>  237

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ile Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Gly Val Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Gly Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  238
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v136 (1-150)

<400>  238

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Gly Val Val Arg Ala Arg Leu Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Ile Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  239
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v137 (1-150)

<400>  239

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ile Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Gly Val Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Met Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Gln Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  240
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v138 (1-150)

<400>  240

Pro Gly Trp Phe Leu Asp Ser Pro Asn Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Asn Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ile Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Gly Val Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Ser Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  241
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v139 (1-150)

<400>  241

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asp Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Thr Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Met Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Leu Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ser Leu Ala Pro Arg Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Ile Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  242
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v140 (1-150)

<400>  242

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Gly Asn Pro Pro Thr 
1               5                   10                  15      


Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Thr Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  243
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v141 (1-150)

<400>  243

Pro Gly Trp Phe Leu Asp Ser Pro Asn Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Thr Ser Pro Ser Asn Gln Ala Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Ser Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Gly Val Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Ser Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  244
<211>  111
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  PD-1 wt (15-125)

<400>  244

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  245
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v1, v37 (15-125)

<400>  245

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  246
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v3 (15-125)

<400>  246

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Tyr Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asp Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Ser Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  247
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v4 (15-125)

<400>  247

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Val Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Gln Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Ala Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  248
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v5 (15-125)

<400>  248

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  249
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v6 (15-125)

<400>  249

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly His Asp Phe Leu Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  250
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v7 (15-125)

<400>  250

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Arg Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Ile Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Ser 
            100                 105                 110     


<210>  251
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v8 (15-125)

<400>  251

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Glu Glu Ser Leu Arg Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  252
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v9 (15-125)

<400>  252

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Val Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp His Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  253
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v10, v12 (15-125)

<400>  253

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Ala Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  254
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v11 (15-125)

<400>  254

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Gly Asn Arg Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Glu Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  255
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v13 (15-125)

<400>  255

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Ala Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Ile 
            100                 105                 110     


<210>  256
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v14, v27, v30, v67  (15-125)

<400>  256

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  257
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v15 (15-125)

<400>  257

Pro Thr Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Glu Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  258
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v16 (15-125)

<400>  258

Pro Thr Phe Thr Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Ala Gln Ile Lys Glu Ser Leu Gln Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  259
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v17 (15-125)

<400>  259

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Leu Thr Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  260
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v18 (15-125)

<400>  260

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Ile 
            100                 105                 110     


<210>  261
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v19 (15-125)

<400>  261

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Ile Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  262
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v20 (15-125)

<400>  262

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Val Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  263
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v21 (15-125)

<400>  263

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Gly Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  264
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v22 (15-125)

<400>  264

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asp Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Ser 
            100                 105                 110     


<210>  265
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v23 (15-125)

<400>  265

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Ala Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Ile 
            100                 105                 110     


<210>  266
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v24 (15-125)

<400>  266

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Ala Gln Ile Lys Glu Ser Leu Pro Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  267
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v25 (15-125)

<400>  267

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Met Val Gln Ile Glu Glu Ser Leu Arg Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  268
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v26 (15-125)

<400>  268

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Gly Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Ile 
            100                 105                 110     


<210>  269
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v28, v29 (15-125)

<400>  269

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Pro Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  270
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v31 (15-125)

<400>  270

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Ser Phe Thr Cys Ser Phe Thr Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Ile 
            100                 105                 110     


<210>  271
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v32 (15-125)

<400>  271

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Thr Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Ile 
            100                 105                 110     


<210>  272
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v33 (15-125)

<400>  272

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Gly Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  273
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v34 (15-125)

<400>  273

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Asp Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  274
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v35 (15-125)

<400>  274

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe Arg Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  275
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v36 (15-125)

<400>  275

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Val Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  276
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v38 (15-125)

<400>  276

Pro Ile Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Ile Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  277
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v39 (15-125)

<400>  277

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Gln Val Glu Leu Arg Val Ile 
            100                 105                 110     


<210>  278
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v40 (15-125)

<400>  278

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Val Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  279
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v41 (15-125)

<400>  279

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Ala Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  280
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v42 (15-125)

<400>  280

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  281
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v43 (15-125)

<400>  281

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Tyr Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  282
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v44 (15-125)

<400>  282

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Tyr Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Leu Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Ala Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  283
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v45 (15-125)

<400>  283

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Tyr Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  284
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v2, v46 (15-125)

<400>  284

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Ala Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  285
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v47 (15-125)

<400>  285

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Met Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe His Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  286
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v48 (15-125)

<400>  286

Pro Thr Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Asp Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Leu Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Ile 
            100                 105                 110     


<210>  287
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v49 (15-125)

<400>  287

Pro Thr Leu Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Ser Phe Thr Cys Asn Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Ser Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Ser Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  288
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v50 (15-125)

<400>  288

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Leu Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  289
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v51 (15-125)

<400>  289

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asp Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Gln Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  290
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v52 (15-125)

<400>  290

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln His Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Pro Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Asp Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  291
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v53 (15-125)

<400>  291

Pro Thr Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Arg Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Ile 
            100                 105                 110     


<210>  292
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v54 (15-125)

<400>  292

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Tyr Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Val Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Gly Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  293
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v55 (15-125)

<400>  293

Pro Thr Leu Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Met Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  294
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v56 (15-125)

<400>  294

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Tyr Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Cys Arg Tyr Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Asp Arg Ala Arg 
65                  70                  75                  80  


Leu Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  295
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v57 (15-125)

<400>  295

Pro Thr Leu Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Thr Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Ser 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu His Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  296
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v58 (15-125)

<400>  296

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  297
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v59 (15-125)

<400>  297

Pro Thr Val Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Val 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Val Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Ser Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Gln Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  298
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v60 (15-125)

<400>  298

Pro Thr Ile Ser Pro Ala Leu Leu Val Val Ala Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Val Ser Pro Thr Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Ser Arg Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  299
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v61 (15-125)

<400>  299

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Leu Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  300
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v62 (15-125)

<400>  300

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Ala Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Gln Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  301
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v63 (15-125)

<400>  301

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Leu Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Pro Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Gly Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  302
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v64 (15-125)

<400>  302

Pro Thr Leu Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Leu Asp Ser Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Gln Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  303
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v65 (15-125)

<400>  303

Pro Thr Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Ser Gly Gln Asp Ser Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Ser Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  304
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v66 (15-125)

<400>  304

Pro Thr Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  305
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v68 (15-125)

<400>  305

Pro Thr Phe Ser Pro Ser Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Gln 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Gln Val Glu Leu Arg Val Ile 
            100                 105                 110     


<210>  306
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v69 (15-125)

<400>  306

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Leu Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Gln Val Glu Leu Arg Val Ile 
            100                 105                 110     


<210>  307
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v70 (15-125)

<400>  307

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Thr Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  308
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v71 (15-125)

<400>  308

Pro Thr Phe Ser Pro Ala Val Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Leu Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  309
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v72 (15-125)

<400>  309

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Arg Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Ala Ser Asn Gln Met Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Ile 
            100                 105                 110     


<210>  310
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v73 (15-125)

<400>  310

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Leu Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Ala Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  311
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v74 (15-125)

<400>  311

Pro Thr Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Val Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Leu Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  312
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v75 (15-125)

<400>  312

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Met Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Leu Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Ile 
            100                 105                 110     


<210>  313
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v76 (15-125)

<400>  313

Pro Thr Ile Ser Pro Val Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Gly Pro Ser Asp Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Ile 
            100                 105                 110     


<210>  314
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v77 (15-125)

<400>  314

Pro Thr Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Asn Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Met Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Gln Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  315
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v78 (15-125)

<400>  315

Pro Thr Val Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Gly Ala Arg 
65                  70                  75                  80  


Leu Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  316
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v79 (15-125)

<400>  316

Pro Thr Leu Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Val Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  317
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v80 (15-125)

<400>  317

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Gly Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Lys 
            100                 105                 110     


<210>  318
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v81 (15-125)

<400>  318

Pro Thr Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  319
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v82 (15-125)

<400>  319

Pro Thr Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  320
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v83 (15-125)

<400>  320

Pro Thr Phe Ser Pro Ala Leu Ile Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ile Gln Pro Ser Arg Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Ile 
            100                 105                 110     


<210>  321
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v84 (15-125)

<400>  321

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  322
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v85 (15-125)

<400>  322

Pro Ser Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  323
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v86 (15-125)

<400>  323

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Ile 
            100                 105                 110     


<210>  324
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v87 (15-125)

<400>  324

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Asp Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  325
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v88 (15-125)

<400>  325

Pro Thr Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Ile Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Arg Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  326
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v89 (15-125)

<400>  326

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  327
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v90 (15-125)

<400>  327

Pro Thr Ile Ser Pro Ala Leu Leu Val Leu Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  328
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v141 (15-125)

<400>  328

Pro Thr Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Thr Ser Pro Ser Asn Gln Ala Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Ser Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Gly Val Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  329
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v92 (15-125)

<400>  329

Pro Thr Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  330
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v93, 117 (15-125)

<400>  330

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  331
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v94 (15-125)

<400>  331

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Val Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp His Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Leu Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asn Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  332
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v95 (15-125)

<400>  332

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Leu Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Ile Gly Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Met Ala Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  333
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v96 (15-125)

<400>  333

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Val Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Ala Gln Ile Lys Glu Ser Leu Trp Val Glu Leu Arg Val Ile 
            100                 105                 110     


<210>  334
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v97 (15-125)

<400>  334

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Gly Pro 
                85                  90                  95      


Lys Val Gln Ile Glu Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  335
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v98 (15-125)

<400>  335

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Arg Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe His Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Ile Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  336
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v99 (15-125)

<400>  336

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Leu Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Pro Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  337
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v100 (15-125)

<400>  337

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Tyr Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  338
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v101 (15-125)

<400>  338

Pro Thr Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Ser Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  339
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v102 (15-125)

<400>  339

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Val Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Arg Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Val Gln 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Thr Val Gln Ile Lys Glu Ser Leu Trp Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  340
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v103 (15-125)

<400>  340

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Leu Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Arg Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Leu Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  341
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v104 (15-125)

<400>  341

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Met Ala Ala Phe 
        35                  40                  45              


Pro Lys Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Gln 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Ile 
            100                 105                 110     


<210>  342
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v105 (15-125)

<400>  342

Pro Thr Tyr Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Arg Thr Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Arg Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Asp Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Val Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Arg Thr Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  343
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v106 (15-125)

<400>  343

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Val Lys Met Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Ser Gly Gln Asp Ser Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  344
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v107 (15-125)

<400>  344

Pro Thr Phe Ser Pro Ala Leu Leu Glu Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Ser Pro Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Tyr Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Ala Asn Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Phe Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  345
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v108 (15-125)

<400>  345

Pro Ala Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Leu Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe Leu Met Ser Val Val Gly Ala Arg 
65                  70                  75                  80  


Leu Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  346
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v109 (15-125)

<400>  346

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Val Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  347
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v110 (15-125)

<400>  347

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Val Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp His Ser Gln Pro Ser Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Ile 
            100                 105                 110     


<210>  348
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v111 (15-125)

<400>  348

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Asn Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Leu Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Ile 
            100                 105                 110     


<210>  349
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v112 (15-125)

<400>  349

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Thr Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Met Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asn Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Gly Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  350
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v113 (15-125)

<400>  350

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Val Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Gln Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  351
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v114 (15-125)

<400>  351

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  352
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v115 (15-125)

<400>  352

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Val Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  353
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v116 (15-125)

<400>  353

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Val Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  354
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v118 (15-125)

<400>  354

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln His Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Val Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  355
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v119 (15-125)

<400>  355

Pro Thr Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asp Thr Pro Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  356
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v120 (15-125)

<400>  356

Pro Thr Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Met Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Ser Asn Gln Pro Cys Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  357
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v121 (15-125)

<400>  357

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Leu Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Ser Asn Gln Pro Cys Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  358
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v122 (15-125)

<400>  358

Pro Thr Phe Ser Pro Ala Leu Leu Gly Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Thr Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  359
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v123 (15-125)

<400>  359

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Ile Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Tyr Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ile Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Val Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Gln Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  360
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v124 (15-125)

<400>  360

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ile Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Gly Val Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  361
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v125 (15-125)

<400>  361

Pro Thr Ile Ser Pro Ala Leu Leu Val Val Ala Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Tyr Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Ile 
            100                 105                 110     


<210>  362
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v126 (15-125)

<400>  362

Pro Thr Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ile Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  363
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v127, v91 (15-125)

<400>  363

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Val Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  364
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v128, v135 (15-125)

<400>  364

Pro Thr Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ile Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Gly Val Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  365
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v129 (15-125)

<400>  365

Pro Thr Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ile Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  366
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v130 (15-125)

<400>  366

Pro Thr Phe Ser Pro Ala Leu Leu Gly Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Pro Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ile Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Gly Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  367
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v131 (15-125)

<400>  367

Pro Thr Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ile Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Gly Val Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Ile 
            100                 105                 110     


<210>  368
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v132 (15-125)

<400>  368

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Thr Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Met Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Leu Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  369
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v133 (15-125)

<400>  369

Pro Thr Ile Ser Pro Ala Leu Leu Val Val Ala Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Tyr Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  370
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v134 (15-125)

<400>  370

Pro Thr Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ile Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Met Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Ala Tyr Leu Cys Ala Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Met Val Gln Ile Lys Glu Ser Leu Trp Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  371
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v136 (15-125)

<400>  371

Pro Thr Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Gly Val Val Arg Ala Arg 
65                  70                  75                  80  


Leu Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Ile 
            100                 105                 110     


<210>  372
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v137 (15-125)

<400>  372

Pro Thr Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ile Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Gly Val Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Met Val Gln Ile Lys Glu Ser Leu Gln Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  373
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v135, v138 (15-125)

<400>  373

Pro Thr Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Asn Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ile Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Gly Val Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  374
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v139 (15-125)

<400>  374

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Thr Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Met Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Leu Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Arg Val Gln Ile Lys Glu Ser Leu Arg Val Glu Leu Arg Val Ile 
            100                 105                 110     


<210>  375
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v140 (15-125)

<400>  375

Pro Thr Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  376
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc (C5S (C220S), R77C, (R292C),  N82G (N297G), V87C (V302C), 
       L232del (K447del))

<400>  376

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln 
65                  70                  75                  80  


Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly 
225                 230     


<210>  377
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc with C220S/L234A/L235E/G237A/K447del

<400>  377

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly 
225                 230     


<210>  378
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc with C220S/E233P/L234V/L235A/G236del/S267K/K447del

<400>  378

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Lys His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly 
225                 230 


<210>  379
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 Fc

<400>  379

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  380
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 Fc S228P

<400>  380

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  381
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 Fc C220S

<400>  381

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  382
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Knob Fc

<400>  382

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  383
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hole Fc

<400>  383

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  384
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Stack Fc (homodimeric)

<400>  384

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  385
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Stuffer

<400>  385

His Met Ser Ser Val Ser Ala Gln 
1               5               


<210>  386
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc (C5S (C220S), R77C, (R292C),  N82G (N297G), V87C (V302C))

<400>  386

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln 
65                  70                  75                  80  


Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  387
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc with C220S/L234A/L235E/G237A

<400>  387

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  388
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc with C220S/E233P/L234V/L235A/G236del/S267K

<400>  388

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Lys His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys 
225                 230     


<210>  389
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH signal peptide

<400>  389

Met Gly Ser Thr Ala Ile Leu Ala Leu Leu Leu Ala Val Leu Gln Gly 
1               5                   10                  15      


Val Ser Ala 
            


<210>  390
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 Fc

<400>  390

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  391
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG2 Fc

<400>  391

Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro 
1               5                   10                  15      


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn 
    50                  55                  60                  


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val 
                85                  90                  95      


Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            100                 105                 110         


Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
        115                 120                 125             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    130                 135                 140                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                165                 170                 175     


Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
            180                 185                 190         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        195                 200                 205             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    210                 215                 220                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 235 


<210>  392
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 wt (6-127)

<400>  392

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  393
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v142 (6-127)

<400>  393

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Ser Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Met Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Leu Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Glu Glu Ser 
            100                 105                 110         


Leu Gln Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  394
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v143 (6-127)

<400>  394

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Val Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Met Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Gln Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  395
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v144 (6-127)

<400>  395

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Ser Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Ser Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Glu Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  396
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v145 (6-127)

<400>  396

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Gln Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  397
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v146 (6-127)

<400>  397

Asp Ser Pro Asp Arg Pro Gly Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Thr Ser Pro Asn 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Arg Gln Pro 
    50                  55                  60                  


Ser Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Val Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Glu Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  398
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v147 (6-127)

<400>  398

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Ile Phe Thr Cys Ser Tyr Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Tyr Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Ser Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Met Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  399
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v148 (6-127)

<400>  399

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Ser Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Asn Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  400
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v149 (6-127)

<400>  400

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  401
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v150 (6-127)

<400>  401

Asp Ser Pro Asp Arg Pro Trp Ser Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Ile Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Ser Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Trp Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  402
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v151 (6-127)

<400>  402

Asp Ser Pro Asp Arg Pro Trp Asn His Pro Ser Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Leu Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Gln Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Glu Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  403
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v152 (6-127)

<400>  403

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Leu Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Ala Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Met Ala Ala Phe Pro Lys Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Gln Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Trp Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  404
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v153 (6-127)

<400>  404

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Arg Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Glu Glu Ser 
            100                 105                 110         


Leu Gln Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  405
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v154 (6-127)

<400>  405

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Ser Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Trp Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  406
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v155 (6-127)

<400>  406

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Ile Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  407
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v156 (6-127)

<400>  407

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Val Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Ser Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Ser Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Glu Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  408
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v157 (6-127)

<400>  408

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Ile Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Arg Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Thr Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  409
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v158 (6-127)

<400>  409

Asp Ser Pro Asp Arg Pro Trp Asn His Pro Ser Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Leu Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Gln Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Met Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Gln Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  410
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v159 (6-127)

<400>  410

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Ile Phe Thr Cys Ser Tyr Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Lys Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Glu Glu Ser 
            100                 105                 110         


Leu Gln Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  411
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v160 (6-127)

<400>  411

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  412
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v161 (6-127)

<400>  412

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Ser Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Glu Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  413
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v162 (6-127)

<400>  413

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Ser Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  414
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v163 (6-127)

<400>  414

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Ser Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  415
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v164 (6-127)

<400>  415

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Ile Trp Asn Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Tyr Lys Leu Ala Ala Phe Pro Glu Asp Arg Cys Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Leu Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  416
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v165 (6-127)

<400>  416

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Ser Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Pro Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  417
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v166 (6-127)

<400>  417

Asp Ser Pro Asp Arg Pro Trp Asn His Pro Thr Ile Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Met Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Glu Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  418
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v167 (6-127)

<400>  418

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Ser Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Ser Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Glu Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  419
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v168 (6-127)

<400>  419

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Gly Phe Val Leu Asn Trp Tyr Arg Leu Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Ser 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Glu Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  420
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v169 (6-127)

<400>  420

Asp Ser Pro Asp Arg Pro Trp Asn His Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Ser Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Glu Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  421
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v170 (6-127)

<400>  421

Asp Ser Pro Asp Arg Pro Trp Ser Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Cys Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Asn Val Asp Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  422
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v171 (6-127)

<400>  422

Asp Ser Pro Asp Arg Pro Gly Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Arg Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Met Val Gln Ile Gln Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  423
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v172 (6-127)

<400>  423

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Asp Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Met Val Gln Ile Gln Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  424
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v173 (6-127)

<400>  424

Asp Ser Pro Asp Arg Pro Trp Ser Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Ile Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Ser Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Met Val Gln Ile Gln Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  425
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v174 (6-127)

<400>  425

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Ile Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Ser Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Asn Val Gln Ile Glu Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  426
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v175 (6-127)

<400>  426

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Leu 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Met Val Arg Ala Arg Arg Asn Asp Ser Gly Ile Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Asn Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  427
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v176 (6-127)

<400>  427

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Leu Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Ala Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Leu 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Met Val Arg Ala Arg Arg Asn Asp Ser Gly Ile Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Asn Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  428
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v177 (6-127)

<400>  428

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Ile Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Ile Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Ser Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Trp Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  429
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v178 (6-127)

<400>  429

Asp Ser Pro Asp Arg Pro Trp Ser Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Arg Ile Glu Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  430
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v179 (6-127)

<400>  430

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Asp Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  431
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v180 (6-127)

<400>  431

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Leu Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Ala Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Gln Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Val Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Glu Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  432
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v181 (6-127)

<400>  432

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Ser Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Glu Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  433
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v182 (6-127)

<400>  433

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Leu 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Asp Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Trp Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  434
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v183 (6-127)

<400>  434

Asp Ser Pro Asp Arg Pro Trp Ser Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Asp Ser Phe Val Leu Asn Trp Tyr Arg Ile Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Val Gln Asn Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Gln Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  435
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v184 (6-127)

<400>  435

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Ile Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Leu 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Met Val Arg Ala Arg Arg Asn Asp Ser Gly Ile Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Asn Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  436
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v185 (6-127)

<400>  436

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Ile Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Asn Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  437
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v186 (6-127)

<400>  437

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  438
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v187 (6-127)

<400>  438

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Ile Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Leu Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  439
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v188 (6-127)

<400>  439

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Leu Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Arg Ser 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  440
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v189 (6-127)

<400>  440

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Thr Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  441
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v190 (6-127)

<400>  441

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly His Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Leu Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  442
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v191 (6-127)

<400>  442

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Thr Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Glu Asn Ala Thr Phe Thr Cys Ser Leu Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Ile Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Arg Ser 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  443
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v192 (6-127)

<400>  443

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Ile Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Leu Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Trp Ile Lys Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  444
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v193 (6-127)

<400>  444

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Met Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Leu Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Leu Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  445
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v194 (6-127)

<400>  445

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Leu Asn 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Asp Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  446
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v195 (6-127)

<400>  446

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Arg Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  447
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v196 (6-127)

<400>  447

Asp Ser Pro Asp Arg Pro Leu Asn Pro Pro Thr Phe Ser Pro Thr Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asp Ala Thr Phe Thr Cys Ser Phe Pro 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Met Ala Ala Phe Pro Glu Asp Arg Ser Arg Ser 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  448
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v197 (6-127)

<400>  448

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Ile Trp Phe Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Val Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Leu 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  449
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v198 (6-127)

<400>  449

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Ile Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Leu Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Gln Glu Ser 
            100                 105                 110         


Leu Gln Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  450
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v199 (6-127)

<400>  450

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asp Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln His 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Leu Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  451
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v200 (6-127)

<400>  451

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Ser Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Lys Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Leu Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  452
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A

<400>  452

Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  453
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v201 (6-127)

<400>  453

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe His Val Ile Trp His Arg Glu Ser Pro Ser 
        35                  40                  45              


Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  454
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v101 (6-127)

<400>  454

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Ile Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Ser Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  455
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v94 (6-127)

<400>  455

Asp Ser Pro Asp Arg Pro Arg Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Val Ala Ala Phe Pro Glu Asp His Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Leu Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  456
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v89 (6-127)

<400>  456

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  457
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 wt (13-127)

<400>  457

Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
1               5                   10                  15      


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
            20                  25                  30          


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
        35                  40                  45              


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
    50                  55                  60                  


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
65                  70                  75                  80  


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
                85                  90                  95      


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
            100                 105                 110         


Thr Glu Arg 
        115 


<210>  458
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v201 (13-127)

<400>  458

Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
1               5                   10                  15      


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe His 
            20                  25                  30          


Val Ile Trp His Arg Glu Ser Pro Ser Gly Gln Thr Asp Thr Leu Ala 
        35                  40                  45              


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
    50                  55                  60                  


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
65                  70                  75                  80  


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Val Cys Gly Val Ile Ser Leu 
                85                  90                  95      


Ala Pro Lys Ile Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
            100                 105                 110         


Thr Glu Arg 
        115 


<210>  459
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v101 (13-127)

<400>  459

Asn Pro Pro Thr Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
1               5                   10                  15      


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val 
            20                  25                  30          


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Ser Asp Lys Leu Ala 
        35                  40                  45              


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
    50                  55                  60                  


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
65                  70                  75                  80  


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
                85                  90                  95      


Ala Pro Lys Val Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
            100                 105                 110         


Thr Glu Arg 
        115 


<210>  460
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v94 (13-127)

<400>  460

Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
1               5                   10                  15      


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
            20                  25                  30          


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Val Ala 
        35                  40                  45              


Ala Phe Pro Glu Asp His Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
    50                  55                  60                  


Val Thr Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Leu Val Arg 
65                  70                  75                  80  


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
                85                  90                  95      


Ala Pro Lys Val Gln Ile Asn Glu Ser Leu Leu Val Glu Leu Arg Val 
            100                 105                 110         


Thr Glu Arg 
        115 


<210>  461
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v89 (13-127)

<400>  461

Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
1               5                   10                  15      


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Pro Glu Ser Phe Val 
            20                  25                  30          


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
        35                  40                  45              


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
    50                  55                  60                  


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
65                  70                  75                  80  


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
                85                  90                  95      


Ala Pro Lys Val Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val 
            100                 105                 110         


Thr Glu Arg 
        115 


<210>  462
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 wt (6-127) C73A

<400>  462

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ala Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  463
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v201 (6-127) C73A

<400>  463

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe His Val Ile Trp His Arg Glu Ser Pro Ser 
        35                  40                  45              


Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ala Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  464
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 wt (6-127) L59C

<400>  464

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Cys Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  465
<211>  71
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8-derived hinge and transmembrane domain

<400>  465

Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
1               5                   10                  15      


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala 
            20                  25                  30          


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Ile 
        35                  40                  45              


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
    50                  55                  60                  


Leu Val Ile Thr Leu Tyr Cys 
65                  70      


<210>  466
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v101 (6-127) L59C

<400>  466

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Ile Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Ser Asp Lys Cys Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  467
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v94 (6-127) L59C

<400>  467

Asp Ser Pro Asp Arg Pro Arg Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Cys Ala Ala Phe Pro Glu Asp His Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Leu Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  468
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v89 (6-127) L59C

<400>  468

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Cys Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  469
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 wt (6-127) L60C

<400>  469

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Cys Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  470
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v201 (6-127) L60C

<400>  470

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe His Val Ile Trp His Arg Glu Ser Pro Ser 
        35                  40                  45              


Gly Gln Thr Asp Thr Leu Cys Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  471
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  471

Gly Ser Gly Gly Gly Gly Ser 
1               5           


<210>  472
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4GS Linker

<400>  472

Gly Gly Gly Gly Ser 
1               5   


<210>  473
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3x G4S Linker

<400>  473

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  474
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2x G4S Linker

<400>  474

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  475
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  475

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala Ala 
1               5                   10              


<210>  476
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Stack Fc (homodimeric)

<400>  476

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly 
225                 230     


<210>  477
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 1

<400>  477

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ser Pro Asp Arg Pro Trp 
    130                 135                 140                 


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
145                 150                 155                 160 


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe His 
                165                 170                 175     


Val Ile Trp His Arg Glu Ser Pro Ser Gly Gln Thr Asp Thr Leu Ala 
            180                 185                 190         


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
        195                 200                 205             


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
    210                 215                 220                 


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Val Cys Gly Val Ile Ser Leu 
225                 230                 235                 240 


Ala Pro Lys Ile Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
                245                 250                 255     


Thr Glu Arg Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly Lys 
        


<210>  478
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 2

<400>  478

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe His Val Ile Trp His Arg Glu Ser Pro Ser 
        35                  40                  45              


Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Thr Gln Glu Lys Glu Val 
    130                 135                 140                 


Arg Ala Met Val Gly Ser Asp Val Glu Leu Ser Cys Ala Cys Pro Glu 
145                 150                 155                 160 


Gly Ser Arg Phe Asp Leu Asn Asp Val Tyr Val Tyr Trp Gln Thr Ser 
                165                 170                 175     


Glu Ser Lys Thr Val Val Thr Tyr His Ile Pro Gln His Ser Ser Leu 
            180                 185                 190         


Glu Asn Val Asp Ser Arg Tyr Arg Asn Arg Ala Leu Met Ser Pro Ala 
        195                 200                 205             


Gly Met Leu Arg Gly Asp Phe Ser Leu Arg Leu Phe Asn Val Thr Pro 
    210                 215                 220                 


Gln Asp Glu Gln Lys Phe His Cys Leu Val Leu Ser Arg Ser Leu Gly 
225                 230                 235                 240 


Phe Gln Glu Val Leu Ser Val Glu Val Thr Leu His Val Ala Ala Asn 
                245                 250                 255     


Phe Ser Val Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly Lys 
        


<210>  479
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 3

<400>  479

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ser Pro Asp Arg Pro Trp 
    130                 135                 140                 


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
145                 150                 155                 160 


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe His 
                165                 170                 175     


Val Ile Trp His Arg Glu Ser Pro Ser Gly Gln Thr Asp Thr Leu Ala 
            180                 185                 190         


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
        195                 200                 205             


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
    210                 215                 220                 


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Val Cys Gly Val Ile Ser Leu 
225                 230                 235                 240 


Ala Pro Lys Ile Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
                245                 250                 255     


Thr Glu Arg Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly Lys 
        


<210>  480
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 4

<400>  480

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe His Val Ile Trp His Arg Glu Ser Pro Ser 
        35                  40                  45              


Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Thr Gln Glu Lys Glu Val 
    130                 135                 140                 


Arg Ala Met Val Gly Ser Asp Val Glu Leu Ser Cys Ala Cys Pro Glu 
145                 150                 155                 160 


Gly Ser Arg Phe Asp Leu Asn Asp Val Tyr Val Tyr Trp Gln Thr Ser 
                165                 170                 175     


Glu Ser Lys Thr Val Val Thr Tyr His Ile Pro Gln His Ser Ser Leu 
            180                 185                 190         


Glu Tyr Val Asp Ser Arg Tyr Arg Asn Arg Ala Leu Met Ser Pro Ala 
        195                 200                 205             


Gly Met Leu Arg Gly Asp Phe Ser Leu Arg Leu Phe Asn Val Thr Pro 
    210                 215                 220                 


Gln Asp Glu Gln Lys Phe His Cys Leu Val Leu Ser Arg Ser Leu Gly 
225                 230                 235                 240 


Phe Gln Glu Val Leu Ser Val Glu Val Thr Leu His Val Ala Ala Asn 
                245                 250                 255     


Phe Ser Val Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly Lys 
        


<210>  481
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 5

<400>  481

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ser Pro Asp Arg Pro Trp 
    130                 135                 140                 


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
145                 150                 155                 160 


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe His 
                165                 170                 175     


Val Ile Trp His Arg Glu Ser Pro Ser Gly Gln Thr Asp Thr Leu Ala 
            180                 185                 190         


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
        195                 200                 205             


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
    210                 215                 220                 


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Val Cys Gly Val Ile Ser Leu 
225                 230                 235                 240 


Ala Pro Lys Ile Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
                245                 250                 255     


Thr Glu Arg Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly Lys 
        


<210>  482
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 6

<400>  482

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe His Val Ile Trp His Arg Glu Ser Pro Ser 
        35                  40                  45              


Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Thr Gln Glu Lys Glu Val 
    130                 135                 140                 


Arg Ala Met Val Gly Ser Asp Val Glu Leu Ser Cys Ala Cys Pro Glu 
145                 150                 155                 160 


Gly Ser Arg Phe Asp Leu Asn Asp Val Tyr Val Tyr Trp Gln Thr Ser 
                165                 170                 175     


Glu Ser Lys Thr Val Val Thr Tyr His Ile Pro Gln Ser Ser Ser Leu 
            180                 185                 190         


Glu Asn Val Asp Ser Arg Tyr Arg Asn Arg Ala Leu Met Ser Pro Ala 
        195                 200                 205             


Gly Met Leu Arg Gly Asp Phe Ser Leu Arg Leu Phe Asn Val Thr Pro 
    210                 215                 220                 


Gln Asp Glu Gln Lys Phe His Cys Leu Val Leu Ser Gln Ser Leu Gly 
225                 230                 235                 240 


Phe Gln Glu Val Leu Ser Val Glu Val Thr Leu His Val Ala Ala Asn 
                245                 250                 255     


Phe Ser Val Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly Lys 
        


<210>  483
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 7

<400>  483

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ser Pro Asp Arg Pro Trp 
    130                 135                 140                 


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
145                 150                 155                 160 


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
                165                 170                 175     


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
            180                 185                 190         


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
        195                 200                 205             


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
    210                 215                 220                 


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
225                 230                 235                 240 


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
                245                 250                 255     


Thr Glu Arg Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly Lys 
        


<210>  484
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 8

<400>  484

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Thr Gln Glu Lys Glu Val 
    130                 135                 140                 


Arg Ala Met Val Gly Ser Asp Val Glu Leu Ser Cys Ala Cys Pro Glu 
145                 150                 155                 160 


Gly Ser Arg Phe Asp Leu Asn Asp Val Tyr Val Tyr Trp Gln Thr Ser 
                165                 170                 175     


Glu Ser Lys Thr Val Val Thr Tyr His Ile Pro Gln His Ser Ser Leu 
            180                 185                 190         


Glu Asn Val Asp Ser Arg Tyr Arg Asn Arg Ala Leu Met Ser Pro Ala 
        195                 200                 205             


Gly Met Leu Arg Gly Asp Phe Ser Leu Arg Leu Phe Asn Val Thr Pro 
    210                 215                 220                 


Gln Asp Glu Gln Lys Phe His Cys Leu Val Leu Ser Arg Ser Leu Gly 
225                 230                 235                 240 


Phe Gln Glu Val Leu Ser Val Glu Val Thr Leu His Val Ala Ala Asn 
                245                 250                 255     


Phe Ser Val Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly Lys 
        


<210>  485
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 9

<400>  485

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ser Pro Asp Arg Pro Trp 
    130                 135                 140                 


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
145                 150                 155                 160 


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
                165                 170                 175     


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
            180                 185                 190         


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
        195                 200                 205             


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
    210                 215                 220                 


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
225                 230                 235                 240 


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
                245                 250                 255     


Thr Glu Arg Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly Lys 
        


<210>  486
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 10

<400>  486

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ser Pro Asp Arg Pro Trp 
    130                 135                 140                 


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
145                 150                 155                 160 


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
                165                 170                 175     


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
            180                 185                 190         


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
        195                 200                 205             


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
    210                 215                 220                 


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
225                 230                 235                 240 


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
                245                 250                 255     


Thr Glu Arg Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly Lys 
        


<210>  487
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 11

<400>  487

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Thr Gln Glu Lys Glu Val 
    130                 135                 140                 


Arg Ala Met Val Gly Ser Asp Val Glu Leu Ser Cys Ala Cys Pro Glu 
145                 150                 155                 160 


Gly Ser Arg Phe Asp Leu Asn Asp Val Tyr Val Tyr Trp Gln Thr Ser 
                165                 170                 175     


Glu Ser Lys Thr Val Val Thr Tyr His Ile Pro Gln Ser Ser Ser Leu 
            180                 185                 190         


Glu Asn Val Asp Ser Arg Tyr Arg Asn Arg Ala Leu Met Ser Pro Ala 
        195                 200                 205             


Gly Met Leu Arg Gly Asp Phe Ser Leu Arg Leu Phe Asn Val Thr Pro 
    210                 215                 220                 


Gln Asp Glu Gln Lys Phe His Cys Leu Val Leu Ser Gln Ser Leu Gly 
225                 230                 235                 240 


Phe Gln Glu Val Leu Ser Val Glu Val Thr Leu His Val Ala Ala Asn 
                245                 250                 255     


Phe Ser Val Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly Lys 
        


<210>  488
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT PD-1-(6-127) Fc

<400>  488

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    130                 135                 140                 


Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
145                 150                 155                 160 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                165                 170                 175     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            180                 185                 190         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        195                 200                 205             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    210                 215                 220                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
225                 230                 235                 240 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                245                 250                 255     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
            260                 265                 270         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        275                 280                 285             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    290                 295                 300                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
305                 310                 315                 320 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                325                 330                 335     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            340                 345                 350         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        355                 360     


<210>  489
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1-v201 Fc

<400>  489

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe His Val Ile Trp His Arg Glu Ser Pro Ser 
        35                  40                  45              


Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    130                 135                 140                 


Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
145                 150                 155                 160 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                165                 170                 175     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            180                 185                 190         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        195                 200                 205             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    210                 215                 220                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
225                 230                 235                 240 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                245                 250                 255     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
            260                 265                 270         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        275                 280                 285             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    290                 295                 300                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
305                 310                 315                 320 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                325                 330                 335     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            340                 345                 350         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        355                 360     


<210>  490
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v142 (1-150)

<400>  490

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Ser Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Met Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Leu Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Glu Glu Ser Leu Gln Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  491
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v143 (1-150)

<400>  491

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Val Ser Pro Ser Asn Gln Thr Asp Lys Met Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Gln Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  492
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v144 (1-150)

<400>  492

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Ser Asn Gly Arg Asp Tyr His Met Ser Val Val Ser Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Glu Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  493
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v145 (1-150)

<400>  493

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Gln Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asp Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  494
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v146 (1-150)

<400>  494

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Gly Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Thr Ser Pro Asn Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Arg Gln Pro Ser Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Val Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Glu Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  495
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v147 (1-150)

<400>  495

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Ile Phe 
            20                  25                  30          


Thr Cys Ser Tyr Ser Asn Thr Ser Glu Ser Tyr Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Ser Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Met Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  496
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v148 (1-150)

<400>  496

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Ser Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Asn Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  497
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v149 (1-150)

<400>  497

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  498
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v150 (1-150)

<400>  498

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Ser Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Ile Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Ser Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Trp Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  499
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v151 (1-150)

<400>  499

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn His Pro Ser 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Gln Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Glu Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  500
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v152 (1-150)

<400>  500

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Leu Ser Pro Ala Leu Leu Val Val Ala Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Met Ala Ala Phe Pro Lys 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Gln Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Trp Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  501
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v153 (1-150)

<400>  501

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Arg Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Glu Glu Ser Leu Gln Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  502
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v154 (1-150)

<400>  502

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Ser Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Trp Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  503
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v155 (1-150)

<400>  503

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Ile Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asp Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  504
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v156 (1-150)

<400>  504

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Val Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Ser Asn Gly Arg Asp Tyr His Met Ser Val Val Ser Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Glu Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  505
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v157 (1-150)

<400>  505

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Ile Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Arg Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Thr Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  506
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v158 (1-150)

<400>  506

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn His Pro Ser 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Gln 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Met Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Gln Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  507
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v159 (1-150)

<400>  507

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Ile Phe 
            20                  25                  30          


Thr Cys Ser Tyr Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Lys 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Glu Glu Ser Leu Gln Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  508
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v160 (1-150)

<400>  508

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  509
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v161 (1-150)

<400>  509

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Ser Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Glu Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  510
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v162 (1-150)

<400>  510

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Ser Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  511
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v163 (1-150)

<400>  511

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Ser Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  512
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v164 (1-150)

<400>  512

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Ile Trp Asn 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Tyr Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Cys Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Leu Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  513
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v165 (1-150)

<400>  513

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Ser Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Pro Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  514
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v166 (1-150)

<400>  514

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn His Pro Thr 
1               5                   10                  15      


Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Met Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Glu Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  515
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v167 (1-150)

<400>  515

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Ser Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Ser Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Glu Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  516
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v168 (1-150)

<400>  516

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Gly Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Ser Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Glu Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  517
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v169 (1-150)

<400>  517

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn His Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Ser Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Glu Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  518
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v170 (1-150)

<400>  518

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Ser Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Cys Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Asn Val Asp Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  519
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v171 (1-150)

<400>  519

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Gly Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Arg Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Met Val 
            100                 105                 110         


Gln Ile Gln Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  520
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v172 (1-150)

<400>  520

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Asp Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Met Val 
            100                 105                 110         


Gln Ile Gln Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  521
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v173 (1-150)

<400>  521

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Ser Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Ile Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Ser Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Met Val 
            100                 105                 110         


Gln Ile Gln Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  522
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v174 (1-150)

<400>  522

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Ile Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Ser Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Asn Val 
            100                 105                 110         


Gln Ile Glu Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  523
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v175 (1-150)

<400>  523

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Leu Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Met Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Ile Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Asn Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  524
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v176 (1-150)

<400>  524

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Leu Ser Pro Ala Leu Leu Val Val Ala Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Leu Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Met Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Ile Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Asn Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  525
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v177 (1-150)

<400>  525

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Ile Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Ile Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Ser Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Trp Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  526
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v178 (1-150)

<400>  526

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Ser Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Arg Ile Glu Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  527
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v179 (1-150)

<400>  527

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Asp Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asp Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  528
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v180 (1-150)

<400>  528

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Leu Ser Pro Ala Leu Leu Val Val Ala Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Gln Asp Tyr His Met Ser Val Val Arg Val Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Glu Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  529
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v181 (1-150)

<400>  529

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Ser Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Glu Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  530
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v182 (1-150)

<400>  530

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Leu Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Asp Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Trp Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  531
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v183 (1-150)

<400>  531

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Ser Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Asp Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Ile Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Val Gln Asn Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Gln Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  532
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v184 (1-150)

<400>  532

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Ile Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Leu Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Met Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Ile Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Asn Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  533
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v185 (1-150)

<400>  533

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Ile Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Asn Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  534
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v186 (1-150)

<400>  534

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  535
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v187 (1-150)

<400>  535

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Ile Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Leu Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  536
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v188 (1-150)

<400>  536

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Arg Ser Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  537
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v189 (1-150)

<400>  537

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Thr Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  538
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v190 (1-150)

<400>  538

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly His Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Leu Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  539
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v191 (1-150)

<400>  539

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Thr Leu Leu Val Val Thr Glu Gly Glu Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Leu Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Ile Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Arg Ser Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  540
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v192 (1-150)

<400>  540

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Ile Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Leu Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Trp Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  541
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v193 (1-150)

<400>  541

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Met Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Leu Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Leu Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  542
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v194 (1-150)

<400>  542

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Leu Asn Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Asp Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  543
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v195 (1-150)

<400>  543

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Arg Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  544
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v196 (1-150)

<400>  544

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Leu Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Thr Leu Leu Val Val Thr Glu Gly Asp Asp Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Pro Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Met Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Arg Ser Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  545
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v197 (1-150)

<400>  545

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Ile Trp Phe 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Val Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Leu Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  546
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v198 (1-150)

<400>  546

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Ile Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Leu Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Gln Glu Ser Leu Gln Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  547
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v199 (1-150)

<400>  547

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asp Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln His Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Leu Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  548
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v200 (1-150)

<400>  548

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Ser Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Lys Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Leu Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  549
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v142 (15-125)

<400>  549

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Ser Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Met Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Leu Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Glu Glu Ser Leu Gln Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  550
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v143 (15-125)

<400>  550

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Val Ser Pro Ser Asn Gln Thr Asp Lys Met Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Gln Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  551
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v144 (15-125)

<400>  551

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Ser Asn Gly Arg Asp Tyr His Met Ser Val Val Ser Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Glu Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  552
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v145 (15-125)

<400>  552

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Gln Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asp Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  553
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v146 (15-125)

<400>  553

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Thr Ser Pro Asn Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Arg Gln Pro Ser Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Val Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Glu Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  554
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v147 (15-125)

<400>  554

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Ile Phe Thr Cys Ser Tyr Ser Asn Thr Ser Glu Ser Tyr Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Ser Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Met Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  555
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v148 (15-125)

<400>  555

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Ser Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Asn Val Gln Ile Asn Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  556
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v149 (15-125)

<400>  556

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  557
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v150 (15-125)

<400>  557

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Ile Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Ser Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asn Glu Ser Leu Trp Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  558
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v151 (15-125)

<400>  558

Pro Ser Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Gln Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Glu Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  559
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v152 (15-125)

<400>  559

Pro Thr Leu Ser Pro Ala Leu Leu Val Val Ala Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Met Ala Ala Phe 
        35                  40                  45              


Pro Lys Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Gln 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asn Glu Ser Leu Trp Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  560
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v153 (15-125)

<400>  560

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Arg Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Glu Glu Ser Leu Gln Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  561
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v154 (15-125)

<400>  561

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Ser Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asn Glu Ser Leu Trp Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  562
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v155 (15-125)

<400>  562

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Ile Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asp Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  563
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v156 (15-125)

<400>  563

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Val Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Ser Asn Gly Arg Asp Tyr His Met Ser Val Val Ser Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Glu Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  564
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v157 (15-125)

<400>  564

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Ile Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Arg Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Thr Val Gln Ile Lys Glu Ser Leu Trp Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  565
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v158 (15-125)

<400>  565

Pro Ser Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Gln Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Met Ala Gln Ile Lys Glu Ser Leu Gln Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  566
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v159 (15-125)

<400>  566

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Ile Phe Thr Cys Ser Tyr Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Lys Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Glu Glu Ser Leu Gln Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  567
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v160 (15-125)

<400>  567

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  568
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v161, v169 (15-125)

<400>  568

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Ser Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Glu Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  569
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v162 (15-125)

<400>  569

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Ser Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  570
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v163 (15-125)

<400>  570

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Ser Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  571
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v164 (15-125)

<400>  571

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Ile 
            20                  25                  30          


Trp Asn Arg Met Ser Pro Ser Asn Gln Thr Tyr Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Cys Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Leu Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  572
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v165 (15-125)

<400>  572

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Ser Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Pro Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  573
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v166 (15-125)

<400>  573

Pro Thr Ile Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Met Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Glu Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  574
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v167 (15-125)

<400>  574

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Ser Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Ser Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Glu Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  575
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v168 (15-125)

<400>  575

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Gly Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Ser Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Glu Glu Ser Leu Arg Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  576
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v170 (15-125)

<400>  576

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Cys Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Asn Val Asp Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  577
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v171 (15-125)

<400>  577

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Arg Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Met Val Gln Ile Gln Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  578
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v172 (15-125)

<400>  578

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Asp Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Met Val Gln Ile Gln Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  579
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v173 (15-125)

<400>  579

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Ile Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Ser Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Met Val Gln Ile Gln Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  580
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v174 (15-125)

<400>  580

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Ile Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Ser Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Asn Val Gln Ile Glu Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  581
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v175 (15-125)

<400>  581

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Leu Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Met Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Ile Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Asn Val Gln Ile Asn Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  582
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v176 (15-125)

<400>  582

Pro Thr Leu Ser Pro Ala Leu Leu Val Val Ala Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Leu Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Met Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Ile Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Asn Val Gln Ile Asn Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  583
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v177 (15-125)

<400>  583

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Ile Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Ile Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Ser Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asn Glu Ser Leu Trp Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  584
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v178 (15-125)

<400>  584

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Arg Ile Glu Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  585
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v179 (15-125)

<400>  585

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Asp Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asp Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  586
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v180 (15-125)

<400>  586

Pro Thr Leu Ser Pro Ala Leu Leu Val Val Ala Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Gln Asp Tyr His Met Ser Val Val Arg Val Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Glu Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  587
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v181 (15-125)

<400>  587

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Ser Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Glu Glu Ser Leu Arg Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  588
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v182 (15-125)

<400>  588

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Leu Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Asp Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asn Glu Ser Leu Trp Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  589
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v183 (15-125)

<400>  589

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Asp Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Ile Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Val Gln Asn Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Gln 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  590
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v184 (15-125)

<400>  590

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Ile Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Leu Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Met Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Ile Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Asn Val Gln Ile Asn Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  591
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v185 (15-125)

<400>  591

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Ile Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Asn Val Gln Ile Asn Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  592
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v186 (15-125)

<400>  592

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asn Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  593
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v187 (15-125)

<400>  593

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Ile Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Leu Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asn Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  594
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v188 (15-125)

<400>  594

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Leu Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Arg Ser Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asn Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  595
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v189 (15-125)

<400>  595

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Thr Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asn Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  596
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v190 (15-125)

<400>  596

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly His Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Leu Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asn Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  597
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v191 (15-125)

<400>  597

Pro Thr Phe Ser Pro Thr Leu Leu Val Val Thr Glu Gly Glu Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Leu Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Ile Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Arg Ser Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  598
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v192 (15-125)

<400>  598

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Ile Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Leu Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Trp Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  599
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v193 (15-125)

<400>  599

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Met Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Leu Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Leu Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asn Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  600
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v194 (15-125)

<400>  600

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Leu Asn Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Asp Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  601
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v195 (15-125)

<400>  601

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Arg Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asn Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  602
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v196 (15-125)

<400>  602

Pro Thr Phe Ser Pro Thr Leu Leu Val Val Thr Glu Gly Asp Asp Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Pro Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Met Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Arg Ser Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Lys Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  603
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v197 (15-125)

<400>  603

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Ile 
            20                  25                  30          


Trp Phe Arg Met Ser Pro Ser Asn Gln Thr Val Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Leu Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asn Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  604
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v198 (15-125)

<400>  604

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Ile Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Leu Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Gln Glu Ser Leu Gln Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  605
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v199 (15-125)

<400>  605

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asp Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln His Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Leu Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asn Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  606
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v200 (15-125)

<400>  606

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Ser Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Lys Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Leu Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asn Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  607
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3zeta intracellular signaling domain

<400>  607

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  608
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antiCD19z chimeric antigen receptor

<400>  608

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser Ala Ala Ala Lys Pro Thr Thr Thr Pro Ala Pro 
                245                 250                 255     


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            260                 265                 270         


Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        275                 280                 285             


Gly Leu Asp Phe Ala Ser Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    290                 295                 300                 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg 
305                 310                 315                 320 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
                325                 330                 335     


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            340                 345                 350         


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        355                 360                 365             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    370                 375                 380                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
385                 390                 395                 400 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                405                 410                 415     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            420                 425                 430     


<210>  609
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8-derived signal sequence

<400>  609

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  610
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8-derived signal sequence

<400>  610

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser 
            20              


<210>  611
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD19 scFv

<400>  611

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210>  612
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8-derived hinge and transmembrane domain

<400>  612

Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
1               5                   10                  15      


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            20                  25                  30          


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45              


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
    50                  55                  60                  


Ser Leu Val Ile Thr 
65                  


<210>  613
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB-derived costimulatory domain

<400>  613

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  614
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28-derived costimulatory domain

<400>  614

Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
1               5                   10                  15      


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
            20                  25                  30          


Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40  


<210>  615
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28-derived costimulatory domain

<400>  615

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  616
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28-derived costimulatory domain

<400>  616

Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
1               5                   10                  15      


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
            20                  25                  30          


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40                  


<210>  617
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Blue fluorescent protein

<400>  617

Ser Glu Leu Ile Lys Glu Asn Met His Met Lys Leu Tyr Met Glu Gly 
1               5                   10                  15      


Thr Val Asp Asn His His Phe Lys Cys Thr Ser Glu Gly Glu Gly Lys 
            20                  25                  30          


Pro Tyr Glu Gly Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly Gly 
        35                  40                  45              


Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr Gly 
    50                  55                  60                  


Ser Lys Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe Lys 
65                  70                  75                  80  


Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr Glu 
                85                  90                  95      


Asp Gly Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp Gly 
            100                 105                 110         


Cys Leu Ile Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser Asn 
        115                 120                 125             


Gly Pro Val Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr Glu 
    130                 135                 140                 


Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met Ala 
145                 150                 155                 160 


Leu Lys Leu Val Gly Gly Ser His Leu Ile Ala Asn Ile Lys Thr Thr 
                165                 170                 175     


Tyr Arg Ser Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val Tyr 
            180                 185                 190         


Tyr Val Asp Tyr Arg Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu Thr 
        195                 200                 205             


Tyr Val Glu Gln His Glu Val Ala Val Ala Arg Tyr Cys Asp Leu Pro 
    210                 215                 220                 


Ser Lys Leu Gly His Lys Leu Asn 
225                 230         


<210>  618
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2nd Gen CAR

<400>  618

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser Ala Ser Ala Lys Pro Thr Thr Thr Pro Ala Pro 
                245                 250                 255     


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            260                 265                 270         


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        275                 280                 285             


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    290                 295                 300                 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Met His Lys Arg 
305                 310                 315                 320 


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
                325                 330                 335     


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
            340                 345                 350         


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
        355                 360                 365             


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
    370                 375                 380                 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
385                 390                 395                 400 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
                405                 410                 415     


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
            420                 425                 430         


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
        435                 440                 445             


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
    450                 455                 460                 


His Met Gln Ala Leu Pro Pro Arg 
465                 470         


<210>  619
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2nd Gen CAR

<400>  619

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser Ala Ser Ala Lys Pro Thr Thr Thr Pro Ala Pro 
                245                 250                 255     


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            260                 265                 270         


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        275                 280                 285             


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    290                 295                 300                 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Met His Lys Arg 
305                 310                 315                 320 


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
                325                 330                 335     


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
            340                 345                 350         


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
        355                 360                 365             


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
    370                 375                 380                 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
385                 390                 395                 400 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
                405                 410                 415     


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
            420                 425                 430         


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
        435                 440                 445             


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
    450                 455                 460                 


His Met Gln Ala Leu Pro Pro Arg Gly Gly Arg Ser Gly Glu Gly Arg 
465                 470                 475                 480 


Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Ser 
                485                 490                 495     


Arg 
    


<210>  620
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2nd Gen CAR with CD28-derived costimulatory domain

<400>  620

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser Ala Ser Ala Lys Pro Thr Thr Thr Pro Ala Pro 
                245                 250                 255     


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            260                 265                 270         


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        275                 280                 285             


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    290                 295                 300                 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Met His Arg Ser 
305                 310                 315                 320 


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
                325                 330                 335     


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
            340                 345                 350         


Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
        355                 360                 365             


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
    370                 375                 380                 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
385                 390                 395                 400 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
                405                 410                 415     


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
            420                 425                 430         


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
        435                 440                 445             


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
    450                 455                 460                 


Met Gln Ala Leu Pro Pro Arg 
465                 470     


<210>  621
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD19 scFv

<400>  621

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser Ala Ala Ala 
                245             


<210>  622
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antiCD19 chimeric antigen receptor

<400>  622
ggcagtggcg agggcagagg aagtctgcta acatgcggtg acgtcgagga gaatcctggc       60

cca                                                                     63


<210>  623
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T2A

<400>  623
ggcagtggcg agggcagagg aagtctgcta acatgcggtg acgtcgagga gaatcctggc       60

cca                                                                     63


<210>  624
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A

<400>  624

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  625
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 hinge and transmembrane domain

<400>  625

Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
1               5                   10                  15      


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            20                  25                  30          


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        35                  40                  45              


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
    50                  55                  60                  


Leu Val Ile Thr 
65              


<210>  626
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A

<400>  626

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  627
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Blue fluorescent protein

<400>  627

Ser Arg Ser Glu Leu Ile Lys Glu Asn Met His Met Lys Leu Tyr Met 
1               5                   10                  15      


Glu Gly Thr Val Asp Asn His His Phe Lys Cys Thr Ser Glu Gly Glu 
            20                  25                  30          


Gly Lys Pro Tyr Glu Gly Thr Gln Thr Met Arg Ile Lys Val Val Glu 
        35                  40                  45              


Gly Gly Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu 
    50                  55                  60                  


Tyr Gly Ser Lys Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe 
65                  70                  75                  80  


Phe Lys Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr 
                85                  90                  95      


Tyr Glu Asp Gly Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln 
            100                 105                 110         


Asp Gly Cys Leu Ile Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Thr 
        115                 120                 125             


Ser Asn Gly Pro Val Met Gln Lys Lys Thr Leu Trp Glu Ala Phe Thr 
    130                 135                 140                 


Glu Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met 
145                 150                 155                 160 


Ala Leu Lys Leu Val Gly Gly Ser His Leu Ile Ala Asn Ile Lys Thr 
                165                 170                 175     


Thr Tyr Arg Ser Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val 
            180                 185                 190         


Tyr Tyr Val Asp Tyr Arg Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu 
        195                 200                 205             


Thr Tyr Val Glu Gln His Glu Val Ala Ala Arg Tyr Cys Asp Leu Pro 
    210                 215                 220                 


Ser Lys Leu Gly His Lys Leu Asn 
225                 230         


<210>  628
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  eGFP

<400>  628

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210>  629
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antiCD19 chimeric antigen receptor CAR-2

<400>  629

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser Ala Ser Ala Lys Pro Thr Thr Thr Pro Ala Pro 
                245                 250                 255     


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            260                 265                 270         


Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        275                 280                 285             


Gly Leu Asp Phe Ala Ser Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    290                 295                 300                 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg 
305                 310                 315                 320 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
                325                 330                 335     


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            340                 345                 350         


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        355                 360                 365             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    370                 375                 380                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
385                 390                 395                 400 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                405                 410                 415     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            420                 425                 430     


<210>  630
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antiCD19 chimeric antigen receptor CAR-2

<400>  630

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
    130                 135                 140                 


Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro 
145                 150                 155                 160 


Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro 
                165                 170                 175     


Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu 
            180                 185                 190         


Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala 
        195                 200                 205             


Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val 
    210                 215                 220                 


Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr 
225                 230                 235                 240 


Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Ala Lys Pro Thr 
            260                 265                 270         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        275                 280                 285             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly 
    290                 295                 300                 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Ile Tyr Ile Trp 
305                 310                 315                 320 


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
                325                 330                 335     


Thr Leu Tyr Cys Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            340                 345                 350         


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        355                 360                 365             


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    370                 375                 380                 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                405                 410                 415     


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            420                 425                 430         


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        435                 440                 445             


Leu Pro Pro Arg Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys 
    450                 455                 460                 


Gly Asp Val Glu Glu Asn Pro Gly Pro Ser Arg Ser Glu Leu Ile Lys 
465                 470                 475                 480 


Glu Asn Met His Met Lys Leu Tyr Met Glu Gly Thr Val Asp Asn His 
                485                 490                 495     


His Phe Lys Cys Thr Ser Glu Gly Glu Gly Lys Pro Tyr Glu Gly Thr 
            500                 505                 510         


Gln Thr Met Arg Ile Lys Val Val Glu Gly Gly Pro Leu Pro Phe Ala 
        515                 520                 525             


Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr Gly Ser Lys Thr Phe Ile 
    530                 535                 540                 


Asn His Thr Gln Gly Ile Pro Asp Phe Phe Lys Gln Ser Phe Pro Glu 
545                 550                 555                 560 


Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr Glu Asp Gly Gly Val Leu 
                565                 570                 575     


Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp Gly Cys Leu Ile Tyr Asn 
            580                 585                 590         


Val Lys Ile Arg Gly Val Asn Phe Thr Ser Asn Gly Pro Val Met Gln 
        595                 600                 605             


Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr Glu Thr Leu Tyr Pro Ala 
    610                 615                 620                 


Asp Gly Gly Leu Glu Gly Arg Asn Asp Met Ala Leu Lys Leu Val Gly 
625                 630                 635                 640 


Gly Ser His Leu Ile Ala Asn Ile Lys Thr Thr Tyr Arg Ser Lys Lys 
                645                 650                 655     


Pro Ala Lys Asn Leu Lys Met Pro Gly Val Tyr Tyr Val Asp Tyr Arg 
            660                 665                 670         


Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu Thr Tyr Val Glu Gln His 
        675                 680                 685             


Glu Val Ala Val Ala Arg Tyr Cys Asp Leu Pro Ser Lys Leu Gly His 
    690                 695                 700                 


Lys Leu Asn 
705         


<210>  631
<211>  8708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD19 chimeric antigen receptor CAR-2

<400>  631
agcttaatgt agtcttatgc aatactcttg tagtcttgca acatggtaac gatgagttag       60

caacatgcct tacaaggaga gaaaaagcac cgtgcatgcc gattggtgga agtaaggtgg      120

tacgatcgtg ccttattagg aaggcaacag acgggtctga catggattgg acgaaccact      180

gaattgccgc attgcagaga tattgtattt aagtgcctag ctcgatacaa taaacgggtc      240

tctctggtta gaccagatct gagcctggga gctctctggc taactaggga acccactgct      300

taagcctcaa taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga      360

ctctggtaac tagagatccc tcagaccctt ttagtcagtg tggaaaatct ctagcagtgg      420

cgcccgaaca gggacttgaa agcgaaaggg aaaccagagg agctctctcg acgcaggact      480

cggcttgctg aagcgcgcac ggcaagaggc gaggggcggc gactggtgag tacgccaaaa      540

attttgacta gcggaggcta gaaggagaga gatgggtgcg agagcgtcag tattaagcgg      600

gggagaatta gatcgcgatg ggaaaaaatt cggttaaggc cagggggaaa gaaaaaatat      660

aaattaaaac atatagtatg ggcaagcagg gagctagaac gattcgcagt taatcctggc      720

ctgttagaaa catcagaagg ctgtagacaa atactgggac agctacaacc atcccttcag      780

acaggatcag aagaacttag atcattatat aatacagtag caaccctcta ttgtgtgcat      840

caaaggatag agataaaaga caccaaggaa gctttagaca agatagagga agagcaaaac      900

aaaagtaaga ccaccgcaca gcaagcggcc gctgatcttc agacctggag gaggagatat      960

gagggacaat tggagaagtg aattatataa atataaagta gtaaaaattg aaccattagg     1020

agtagcaccc accaaggcaa agagaagagt ggtgcagaga gaaaaaagag cagtgggaat     1080

aggagctttg ttccttgggt tcttgggagc agcaggaagc actatgggcg cagcctcaat     1140

gacgctgacg gtacaggcca gacaattatt gtctggtata gtgcagcagc agaacaattt     1200

gctgagggct attgaggcgc aacagcatct gttgcaactc acagtctggg gcatcaagca     1260

gctccaggca agaatcctgg ctgtggaaag atacctaaag gatcaacagc tcctggggat     1320

ttggggttgc tctggaaaac tcatttgcac cactgctgtg ccttggaatg ctagttggag     1380

taataaatct ctggaacaga tttggaatca cacgacctgg atggagtggg acagagaaat     1440

taacaattac acaagcttaa tacactcctt aattgaagaa tcgcaaaacc agcaagaaaa     1500

gaatgaacaa gaattattgg aattagataa atgggcaagt ttgtggaatt ggtttaacat     1560

aacaaattgg ctgtggtata taaaattatt cataatgata gtaggaggct tggtaggttt     1620

aagaatagtt tttgctgtac tttctatagt gaatagagtt aggcagggat attcaccatt     1680

atcgtttcag acccacctcc caaccccgag gggacccgac aggcccgaag gaatagaaga     1740

agaaggtgga gagagagaca gagacagatc cattcgatta gtgaacggat ctcgacggta     1800

tcggttaact tttaaaagaa aaggggggat tggggggtac agtgcagggg aaagaatagt     1860

agacataata gcaacagaca tacaaactaa agaattacaa aaacaaatta caaaaattca     1920

aaattttatc gatcacgaga ctagcctcga gaagcttgat atcgaattcc cacggggttg     1980

gacgcgtagg aacagagaaa caggagaata tgggccaaac aggatatctg tggtaagcag     2040

ttcctgcccc ggctcagggc caagaacagt tggaacagca gaatatgggc caaacaggat     2100

atctgtggta agcagttcct gccccggctc agggccaaga acagatggtc cccagatgcg     2160

gtcccgccct cagcagtttc tagagaacca tcagatgttt ccagggtgcc ccaaggacct     2220

gaaatgaccc tgtgccttat ttgaactaac caatcagttc gcttctcgct tctgttcgcg     2280

cgcttctgct ccccgagctc tatataagca gagctcgttt agtgaaccgt cagatcgcct     2340

ggagacgcca tccacgctgt tttgacttcc atagaaggat cccctgcagg taatacgact     2400

cactataggg tccactgccg ccaccatggc tctgcctgtg acagctctgc tgctgcctct     2460

ggccctgctg ctccatgccg ccagacccgg atccgatatc cagatgaccc agaccaccag     2520

cagcctgagc gccagcctgg gcgatagagt gaccatcagc tgcagagcca gccaggacat     2580

cagcaagtac ctgaactggt atcagcagaa acccgacggc accgtgaagc tgctgatcta     2640

ccacaccagc agactgcaca gcggcgtgcc cagcagattt tctggcagcg gctccggcac     2700

cgactacagc ctgaccatct ccaacctgga acaggaagat atcgctacct acttctgtca     2760

gcaaggcaac accctgccct acaccttcgg cggaggcacc aagctggaaa tcaccggcag     2820

cacaagcggc agcggcaagc ctggatctgg cgagggaagc accaagggcg aagtgaaact     2880

gcaggaaagc ggccctggac tggtggcccc aagccagtct ctgagcgtga cctgtaccgt     2940

gtccggcgtg tccctgcctg actatggcgt gtcctggatc agacagccac ccagaaaggg     3000

cctggaatgg ctgggagtga tctggggcag cgagacaacc tactacaaca gcgccctgaa     3060

gtcccggctg accatcatca aggacaactc caagagccag gtgttcctga agatgaacag     3120

cctgcagacc gacgacaccg ccatctacta ctgcgccaag cactactact acggcggcag     3180

ctacgccatg gactactggg gccagggcac aagcgtgacc gtgtccagcg ctagcgccaa     3240

gcccaccacg acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc     3300

cctgtccctg cgcccagagg cgagccggcc agcggcgggg ggcgcagtgc acacgagggg     3360

gctggacttc gccagtgata tctacatctg ggcgcccctg gccgggactt gtggggtcct     3420

tctcctgtca ctggttatca ccctttactg cagagtgaag ttcagcagga gcgcagacgc     3480

ccccgcgtac cagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga     3540

ggagtacgat gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag     3600

aaggaagaac cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc     3660

ctacagtgag attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta     3720

ccagggtctc agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc     3780

ccctcgcggc agtggcgagg gcagaggaag tctgctaaca tgcggtgacg tggaggagaa     3840

tccgggcccc tctagaagcg agctgattaa ggagaacatg cacatgaagc tgtacatgga     3900

gggcaccgtg gacaaccatc acttcaagtg cacatccgag ggcgaaggca agccctacga     3960

gggcacccag accatgagaa tcaaggtggt cgagggcggc cctctcccct tcgccttcga     4020

catcctggct actagcttcc tctacggcag caagaccttc atcaaccaca cccagggcat     4080

ccccgacttc ttcaagcagt ccttccctga gggcttcaca tgggagagag tcaccacata     4140

cgaagacggg ggcgtgctga ccgctaccca ggacaccagc ctccaggacg gctgcctcat     4200

ctacaacgtc aagatcagag gggtgaactt cacatccaac ggccctgtga tgcagaagaa     4260

aacactcggc tgggaggcct tcaccgagac gctgtacccc gctgacggcg gcctggaagg     4320

cagaaacgac atggccctga agctcgtggg cgggagccat ctgatcgcaa acatcaagac     4380

cacatataga tccaagaaac ccgctaagaa cctcaagatg cctggcgtct actatgtgga     4440

ctacagactg gaaagaatca aggaggccaa caacgagacc tacgtcgagc agcacgaggt     4500

ggcagtggcc agatactgcg acctccctag caaactgggg cacaagctta attgagtcga     4560

caatcaacct ctggattaca aaatttgtga aagattgact ggtattctta actatgttgc     4620

tccttttacg ctatgtggat acgctgcttt aatgcctttg tatcatgcta ttgcttcccg     4680

tatggctttc attttctcct ccttgtataa atcctggttg ctgtctcttt atgaggagtt     4740

gtggcccgtt gtcaggcaac gtggcgtggt gtgcactgtg tttgctgacg caacccccac     4800

tggttggggc attgccacca cctgtcagct cctttccggg actttcgctt tccccctccc     4860

tattgccacg gcggaactca tcgccgcctg ccttgcccgc tgctggacag gggctcggct     4920

gttgggcact gacaattccg tggtgttgtc ggggaagctg acgtcctttc catggctgct     4980

cgcctgtgtt gccacctgga ttctgcgcgg gacgtccttc tgctacgtcc cttcggccct     5040

caatccagcg gaccttcctt cccgcggcct gctgccggct ctgcggcctc ttccgcgtct     5100

tcgccttcgc cctcagacga gtcggatctc cctttgggcc gcctccccgc ctggaattcg     5160

agctcggtac ctttaagacc aatgacttac aaggcagctg tagatcttag ccacttttta     5220

aaagaaaagg ggggactgga agggctaatt cactcccaac gaagacaaga tctgcttttt     5280

gcttgtactg ggtctctctg gttagaccag atctgagcct gggagctctc tggctaacta     5340

gggaacccac tgcttaagcc tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc     5400

cgtctgttgt gtgactctgg taactagaga tccctcagac ccttttagtc agtgtggaaa     5460

atctctagca gtagtagttc atgtcatctt attattcagt atttataact tgcaaagaaa     5520

tgaatatcag agagtgagag gaacttgttt attgcagctt ataatggtta caaataaagc     5580

aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag ttgtggtttg     5640

tccaaactca tcaatgtatc ttatcatgtc tggctctagc tatcccgccc ctaactccgc     5700

ccagttccgc ccattctccg ccccatggct gactaatttt ttttatttat gcagaggccg     5760

aggccgcctc ggcctctgag ctattccaga agtagtgagg aggctttttt ggaggcctag     5820

gcttttgcgt cgagacgtac ccaattcgcc ctatagtgag tcgtattacg cgcgctcact     5880

ggccgtcgtt ttacaacgtc gtgactggga aaaccctggc gttacccaac ttaatcgcct     5940

tgcagcacat ccccctttcg ccagctggcg taatagcgaa gaggcccgca ccgatcgccc     6000

ttcccaacag ttgcgcagcc tgaatggcga atggcgcgac gcgccctgta gcggcgcatt     6060

aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc     6120

gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca     6180

agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc     6240

caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt     6300

tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac     6360

aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc     6420

ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta acaaaatatt     6480

aacgtttaca atttcccagg tggcactttt cggggaaatg tgcgcggaac ccctatttgt     6540

ttatttttct aaatacattc aaatatgtat ccgctcatga gacaataacc ctgataaatg     6600

cttcaataat attgaaaaag gaagagtatg agtattcaac atttccgtgt cgcccttatt     6660

cccttttttg cggcattttg ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta     6720

aaagatgctg aagatcagtt gggtgcacga gtgggttaca tcgaactgga tctcaacagc     6780

ggtaagatcc ttgagagttt tcgccccgaa gaacgttttc caatgatgag cacttttaaa     6840

gttctgctat gtggcgcggt attatcccgt attgacgccg ggcaagagca actcggtcgc     6900

cgcatacact attctcagaa tgacttggtt gagtactcac cagtcacaga aaagcatctt     6960

acggatggca tgacagtaag agaattatgc agtgctgcca taaccatgag tgataacact     7020

gcggccaact tacttctgac aacgatcgga ggaccgaagg agctaaccgc ttttttgcac     7080

aacatggggg atcatgtaac tcgccttgat cgttgggaac cggagctgaa tgaagccata     7140

ccaaacgacg agcgtgacac cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta     7200

ttaactggcg aactacttac tctagcttcc cggcaacaat taatagactg gatggaggcg     7260

gataaagttg caggaccact tctgcgctcg gcccttccgg ctggctggtt tattgctgat     7320

aaatctggag ccggtgagcg tgggtctcgc ggtatcattg cagcactggg gccagatggt     7380

aagccctccc gtatcgtagt tatctacacg acggggagtc aggcaactat ggatgaacga     7440

aatagacaga tcgctgagat aggtgcctca ctgattaagc attggtaact gtcagaccaa     7500

gtttactcat atatacttta gattgattta aaacttcatt tttaatttaa aaggatctag     7560

gtgaagatcc tttttgataa tctcatgacc aaaatccctt aacgtgagtt ttcgttccac     7620

tgagcgtcag accccgtaga aaagatcaaa ggatcttctt gagatccttt ttttctgcgc     7680

gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg tttgccggat     7740

caagagctac caactctttt tccgaaggta actggcttca gcagagcgca gataccaaat     7800

actgtccttc tagtgtagcc gtagttaggc caccacttca agaactctgt agcaccgcct     7860

acatacctcg ctctgctaat cctgttacca gtggctgctg ccagtggcga taagtcgtgt     7920

cttaccgggt tggactcaag acgatagtta ccggataagg cgcagcggtc gggctgaacg     7980

gggggttcgt gcacacagcc cagcttggag cgaacgacct acaccgaact gagataccta     8040

cagcgtgagc tatgagaaag cgccacgctt cccgaaggga gaaaggcgga caggtatccg     8100

gtaagcggca gggtcggaac aggagagcgc acgagggagc ttccaggggg aaacgcctgg     8160

tatctttata gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc     8220

tcgtcagggg ggcggagcct atggaaaaac gccagcaacg cggccttttt acggttcctg     8280

gccttttgct ggccttttgc tcacatgttc tttcctgcgt tatcccctga ttctgtggat     8340

aaccgtatta ccgcctttga gtgagctgat accgctcgcc gcagccgaac gaccgagcgc     8400

agcgagtcag tgagcgagga agcggaagag cgcccaatac gcaaaccgcc tctccccgcg     8460

cgttggccga ttcattaatg cagctggcac gacaggtttc ccgactggaa agcgggcagt     8520

gagcgcaacg caattaatgt gagttagctc actcattagg caccccaggc tttacacttt     8580

atgcttccgg ctcgtatgtt gtgtggaatt gtgagcggat aacaatttca cacaggaaac     8640

agctatgacc atgattacgc caagcgcgca attaaccctc actaaaggga acaaaagctg     8700

gagctgca                                                              8708


<210>  632
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antiCD19 chimeric antigen receptor CAR-1

<400>  632

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser Ala Ser Ala Lys Pro Thr Thr Thr Pro Ala Pro 
                245                 250                 255     


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            260                 265                 270         


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        275                 280                 285             


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    290                 295                 300                 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Arg Val Lys Phe 
305                 310                 315                 320 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
                325                 330                 335     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            340                 345                 350         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        355                 360                 365             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    370                 375                 380                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
385                 390                 395                 400 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                405                 410                 415     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            420                 425             


<210>  633
<211>  706
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antiCD19 chimeric antigen receptor CAR-1

<400>  633

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Gln Met Thr Gln Thr Thr Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp 
    50                  55                  60                  


Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu 
                85                  90                  95      


Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln 
            100                 105                 110         


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly 
    130                 135                 140                 


Ser Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val 
145                 150                 155                 160 


Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser 
                165                 170                 175     


Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly 
            180                 185                 190         


Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn 
        195                 200                 205             


Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser 
    210                 215                 220                 


Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile 
225                 230                 235                 240 


Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Ala Lys 
            260                 265                 270         


Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
            340                 345                 350         


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
        355                 360                 365             


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
    370                 375                 380                 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
                405                 410                 415     


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
            420                 425                 430         


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
        435                 440                 445             


Pro Pro Arg Gly Gly Arg Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr 
    450                 455                 460                 


Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Ser Arg Ser Glu Leu Ile 
465                 470                 475                 480 


Lys Glu Asn Met His Met Lys Leu Tyr Met Glu Gly Thr Val Asp Asn 
                485                 490                 495     


His His Phe Lys Cys Thr Ser Glu Gly Glu Gly Lys Pro Tyr Glu Gly 
            500                 505                 510         


Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly Gly Pro Leu Pro Phe 
        515                 520                 525             


Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr Gly Ser Lys Thr Phe 
    530                 535                 540                 


Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe Lys Gln Ser Phe Pro 
545                 550                 555                 560 


Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr Glu Asp Gly Gly Val 
                565                 570                 575     


Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp Gly Cys Leu Ile Tyr 
            580                 585                 590         


Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser Asn Gly Pro Val Met 
        595                 600                 605             


Gln Lys Lys Thr Leu Trp Glu Ala Phe Thr Glu Thr Leu Tyr Pro Ala 
    610                 615                 620                 


Asp Gly Gly Leu Glu Gly Arg Asn Asp Met Ala Leu Lys Leu Val Gly 
625                 630                 635                 640 


Gly Ser His Leu Ile Ala Asn Ile Lys Thr Thr Tyr Arg Ser Lys Lys 
                645                 650                 655     


Pro Ala Lys Asn Leu Lys Met Pro Gly Val Tyr Tyr Val Asp Tyr Arg 
            660                 665                 670         


Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu Thr Tyr Val Glu Gln His 
        675                 680                 685             


Glu Val Ala Ala Arg Tyr Cys Asp Leu Pro Ser Lys Leu Gly His Lys 
    690                 695                 700                 


Leu Asn 
705     


<210>  634
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EAAAK Linker

<400>  634

Glu Ala Ala Ala Lys 
1               5   


<210>  635
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3x EAAAK Linker

<400>  635

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15  


<210>  636
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5x EAAAK Linker

<400>  636

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu 
1               5                   10                  15      


Ala Ala Ala Lys Glu Ala Ala Ala Lys 
            20                  25  


<210>  637
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAS

<400>  637

Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro 
1               5                   10                  15      


Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala 
            20                  25                  30          


Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro 
        35                  40                  45              


Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala 
    50                  55                  60                  


Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala 
65                  70                  75                  80  


Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro 
                85                  90                  95      


Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala 
            100                 105                 110         


Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro 
        115                 120                 125             


Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala 
    130                 135                 140                 


Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala 
145                 150                 155                 160 


Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro 
                165                 170                 175     


Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala 
            180                 185                 190         


Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro 
        195                 200                 205             


Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala 
    210                 215                 220                 


Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala 
225                 230                 235                 240 


Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro 
                245                 250                 255     


Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala 
            260                 265                 270         


Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro 
        275                 280                 285             


Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala 
    290                 295                 300                 


Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala 
305                 310                 315                 320 


Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro 
                325                 330                 335     


Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala 
            340                 345                 350         


Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala Ala Pro Ala Pro 
        355                 360                 365             


Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala Ala Ser Pro Ala 
    370                 375                 380                 


Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro Ser Ala Pro Ala 
385                 390                 395                 400 


<210>  638
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A

<400>  638

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  639
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flag tag

<400>  639

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  640
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His tag

<400>  640

His His His His His His 
1               5       


<210>  641
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  eGFP

<400>  641

Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
1               5                   10                  15      


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly 
            20                  25                  30          


Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
        35                  40                  45              


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
    50                  55                  60                  


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
65                  70                  75                  80  


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
                85                  90                  95      


Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys 
            100                 105                 110         


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
        115                 120                 125             


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr 
    130                 135                 140                 


Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile 
145                 150                 155                 160 


Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln 
                165                 170                 175     


Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val 
            180                 185                 190         


Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys 
        195                 200                 205             


Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr 
    210                 215                 220                 


Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235         


<210>  642
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Green fluorescent protein

<400>  642

Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
1               5                   10                  15      


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly 
            20                  25                  30          


Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
        35                  40                  45              


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Ser 
    50                  55                  60                  


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
65                  70                  75                  80  


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
                85                  90                  95      


Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys 
            100                 105                 110         


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
        115                 120                 125             


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr 
    130                 135                 140                 


Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile 
145                 150                 155                 160 


Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln 
                165                 170                 175     


Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val 
            180                 185                 190         


Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys 
        195                 200                 205             


Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr 
    210                 215                 220                 


Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235         


<210>  643
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS(G4S)3 linker

<400>  643

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser 
    


<210>  644
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS(G4S)5 linker

<400>  644

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25          


<210>  645
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 wt (6-127) C73R

<400>  645

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  646
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 wt (6-127) C73S

<400>  646

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  647
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v1, v37 (6-127)

<400>  647

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  648
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v2 (6-127)

<400>  648

Asp Ser Pro Asp Arg Pro Trp Ser Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  649
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v3 (6-127)

<400>  649

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Tyr Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asp Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Ser Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  650
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v4 (6-127)

<400>  650

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Val Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Gln Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  651
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v5 (6-127)

<400>  651

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  652
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v6 (6-127)

<400>  652

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly His Asp 
65                  70                  75                  80  


Phe Leu Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  653
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v7 (6-127)

<400>  653

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Arg Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Ile Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Ser Glu Arg 
        115                 120         


<210>  654
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v8 (6-127)

<400>  654

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Glu Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  655
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v9 (6-127)

<400>  655

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Leu Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Val Ala Ala Phe Pro Glu Asp His Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  656
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v10, v12 (6-127)

<400>  656

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  657
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v11 (6-127)

<400>  657

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Gly 
        35                  40                  45              


Asn Arg Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Glu Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  658
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v138 (6-127)

<400>  658

Asp Ser Pro Asn Arg Pro Trp Asn Pro Pro Thr Ile Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Asn Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Leu Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ile Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Gly Val Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  659
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v13 (6-127)

<400>  659

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Ile Glu Arg 
        115                 120         


<210>  660
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v14, v27, v67 (6-127)

<400>  660

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  661
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v15 (6-127)

<400>  661

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Ile Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Glu Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  662
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v16 (6-127)

<400>  662

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Thr Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Gln Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  663
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v17 (6-127)

<400>  663

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Leu Thr 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  664
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v18 (6-127)

<400>  664

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Ile Glu Arg 
        115                 120         


<210>  665
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v19 (6-127)

<400>  665

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Ile Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  666
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v20 (6-127)

<400>  666

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Val Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  667
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v21 (6-127)

<400>  667

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Gly Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  668
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v22 (6-127)

<400>  668

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asp Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Ser Glu Arg 
        115                 120         


<210>  669
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v23 (6-127)

<400>  669

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Ile Glu Arg 
        115                 120         


<210>  670
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v24 (6-127)

<400>  670

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Pro Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  671
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v25 (6-127)

<400>  671

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Met Val Gln Ile Glu Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  672
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v26 (6-127)

<400>  672

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Gly Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Ile Glu Arg 
        115                 120         


<210>  673
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v139 (6-127)

<400>  673

Asp Ser Pro Asp Arg Pro Trp Asp Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Thr Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Met Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Leu Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Ala Ala Ile Ser Leu Ala Pro Arg Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Ile Glu Arg 
        115                 120         


<210>  674
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v28 (6-127)

<400>  674

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Pro 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  675
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v29 (6-127)

<400>  675

Asp Ser Pro Asp Arg Pro Leu Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Pro 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  676
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v30 (6-127)

<400>  676

Asp Ser Pro Gly Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  677
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v31 (6-127)

<400>  677

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Ser Phe Thr Cys Ser Phe Thr 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Ile Glu Arg 
        115                 120         


<210>  678
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v32 (6-127)

<400>  678

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Thr 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Ile Glu Arg 
        115                 120         


<210>  679
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v33 (6-127)

<400>  679

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Gly Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  680
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v34 (6-127)

<400>  680

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Asp Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  681
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v35 (6-127)

<400>  681

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe Arg Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  682
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v36 (6-127)

<400>  682

Asp Ser Pro Asp Arg Pro Trp Asp Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Val Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  683
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v140 (6-127)

<400>  683

Asp Ser Pro Asp Arg Pro Gly Asn Pro Pro Thr Ile Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Leu Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  684
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v38 (6-127)

<400>  684

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Ile Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Ile Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  685
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v39 (6-127)

<400>  685

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Leu Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Gln Val Glu Leu Arg Val Ile Glu Arg 
        115                 120         


<210>  686
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v40 (6-127)

<400>  686

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Val Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  687
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v41 (6-127)

<400>  687

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  688
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v42 (6-127)

<400>  688

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  689
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v43 (6-127)

<400>  689

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Tyr Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  690
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v44 (6-127)

<400>  690

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Tyr Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Leu 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  691
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v45 (6-127)

<400>  691

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Tyr Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  692
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v46 (6-127)

<400>  692

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  693
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v47 (6-127)

<400>  693

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Met Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe His Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  694
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v48 (6-127)

<400>  694

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Ile Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Asp Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Leu Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Ile Glu Arg 
        115                 120         


<210>  695
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v49 (6-127)

<400>  695

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Leu Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Ser Phe Thr Cys Asn Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Ser Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Ser Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  696
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v50 (6-127)

<400>  696

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Leu Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  697
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v51 (6-127)

<400>  697

Asp Ser Pro Asp Arg Pro Leu Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asp Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Gln Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  698
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v52 (6-127)

<400>  698

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln His 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Pro Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Asp Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  699
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v53 (6-127)

<400>  699

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Ile Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Arg Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Ile Glu Arg 
        115                 120         


<210>  700
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v54 (6-127)

<400>  700

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Tyr Val Leu Asn Trp Tyr Arg Val Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Gly Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  701
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v55 (6-127)

<400>  701

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Leu Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Met Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  702
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v56 (6-127)

<400>  702

Asp Ser Pro Asp Arg Pro Leu Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Tyr Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Tyr Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Asp Arg Ala Arg Leu Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Ala Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  703
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v57 (6-127)

<400>  703

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Leu Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Thr 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Ser Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu His Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  704
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v58 (6-127)

<400>  704

Asp Ser Pro Asp Arg Pro Trp Asp Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  705
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v59 (6-127)

<400>  705

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Val Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Val Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Val Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Ser Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Gln Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  706
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v60 (6-127)

<400>  706

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Ile Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Ala Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Val Ser Pro Thr 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Ser Arg Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  707
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v61 (6-127)

<400>  707

Asp Ser Pro Asp Arg Pro Trp Asp Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Leu Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Ala Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  708
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v62 (6-127)

<400>  708

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Ala Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Gln Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  709
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v63 (6-127)

<400>  709

Asp Ser Pro Asp Arg Pro Trp Tyr Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Leu Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Pro Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Gly Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  710
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v64 (6-127)

<400>  710

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Leu Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Leu Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Gln Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  711
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v65 (6-127)

<400>  711

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Ile Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Ser 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Ser Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Ala Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  712
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v66 (6-127)

<400>  712

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Ile Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  713
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v141 (6-127)

<400>  713

Asp Ser Pro Asn Arg Pro Trp Asn Pro Pro Thr Ile Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Thr Ser Pro Ser 
        35                  40                  45              


Asn Gln Ala Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Ser Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Gly Val Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  714
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v68 (6-127)

<400>  714

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ser Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Gln Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Gln Val Glu Leu Arg Val Ile Glu Arg 
        115                 120         


<210>  715
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v69 (6-127)

<400>  715

Asp Ser Pro Asp Arg Pro Trp Asp Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Leu Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Gln Val Glu Leu Arg Val Ile Glu Arg 
        115                 120         


<210>  716
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v70 (6-127)

<400>  716

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Thr Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  717
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v71 (6-127)

<400>  717

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Val 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Leu Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Ala Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  718
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v72 (6-127)

<400>  718

Asp Ser Pro Asp Arg Pro Trp Asn Ser Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Arg Phe Val Leu Asn Trp Tyr Arg Met Ser Ala Ser 
        35                  40                  45              


Asn Gln Met Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Ile Glu Arg 
        115                 120         


<210>  719
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v73 (6-127)

<400>  719

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Leu Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Ala Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  720
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v74 (6-127)

<400>  720

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Ile Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Val Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Leu Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Ala Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  721
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v75 (6-127)

<400>  721

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Met Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Leu Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Ile Glu Arg 
        115                 120         


<210>  722
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v76 (6-127)

<400>  722

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Ile Ser Pro Val Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Gly Pro Ser 
        35                  40                  45              


Asp Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Ile Glu Arg 
        115                 120         


<210>  723
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v77 (6-127)

<400>  723

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Ile Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Asn Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Met Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Ala Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Gln Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  724
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v78 (6-127)

<400>  724

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Val Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Gly Ala Arg Leu Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  725
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v79 (6-127)

<400>  725

Asp Ser Pro Asp Arg Pro Gly Asn Pro Pro Thr Leu Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Val Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  726
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v80 (6-127)

<400>  726

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Gly Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Lys Glu Arg 
        115                 120         


<210>  727
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v81 (6-127)

<400>  727

Asp Ser Thr Asp Arg Pro Trp Asn Pro Pro Thr Ile Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Ala Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  728
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v82 (6-127)

<400>  728

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Ile Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  729
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v83 (6-127)

<400>  729

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Ile Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ile Gln Pro 
    50                  55                  60                  


Ser Arg Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Ile Glu Arg 
        115                 120         


<210>  730
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v84 (6-127)

<400>  730

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  731
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v85 (6-127)

<400>  731

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Ser Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  732
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v86 (6-127)

<400>  732

Asp Ser Pro Asp Arg Pro Trp Asp Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Ile Glu Arg 
        115                 120         


<210>  733
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v87 (6-127)

<400>  733

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Leu Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Asp Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  734
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v88 (6-127)

<400>  734

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Ile Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Ile Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Arg Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  735
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v90 (6-127)

<400>  735

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Ile Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Leu Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  736
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v91 (6-127)

<400>  736

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Val Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  737
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v92 (6-127)

<400>  737

Asp Ser Pro Asp Arg Pro Trp Asp Pro Pro Thr Ile Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  738
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v93, v117 (6-127)

<400>  738

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  739
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v95 (6-127)

<400>  739

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Leu Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Ile Gly Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Met Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  740
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v96 (6-127)

<400>  740

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Val Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Val Glu Leu Arg Val Ile Glu Arg 
        115                 120         


<210>  741
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v97 (6-127)

<400>  741

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Gly Pro Lys Val Gln Ile Glu Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  742
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v98 (6-127)

<400>  742

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Arg Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe His Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Ile Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  743
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v99 (6-127)

<400>  743

Asp Ser Pro Asp Arg Pro Arg Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Leu Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Pro Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  744
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v100 (6-127)

<400>  744

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Tyr Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  745
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v102 (6-127)

<400>  745

Asp Ser Pro Asp Arg Pro Leu Asn Ser Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Val Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Arg Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Val Gln Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Thr Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  746
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v103 (6-127)

<400>  746

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Leu Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Arg Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Leu Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  747
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v104 (6-127)

<400>  747

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Met Ala Ala Phe Pro Lys Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Gln Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Ile Glu Arg 
        115                 120         


<210>  748
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v105 (6-127)

<400>  748

Asp Ser Pro Asp Arg Pro Trp Asn His Pro Thr Tyr Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Arg Thr Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Arg Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Asp Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Val Ala Ile Ser Leu Ala Pro Lys Val Arg Thr Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  749
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v106 (6-127)

<400>  749

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Val Lys Met Ala Ala Phe Pro Glu Asp Arg Ser Gln Ser 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  750
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v107 (6-127)

<400>  750

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Glu Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Ser Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Tyr Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Ala Asn Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Phe Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  751
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v108 (6-127)

<400>  751

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Ala Ile Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Leu Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe Leu Met Ser Val Val Gly Ala Arg Leu Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  752
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v109 (6-127)

<400>  752

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Val Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  753
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v110 (6-127)

<400>  753

Asp Ser Pro Asp Arg Pro Trp Asn Ser Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Leu Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Val Ala Ala Phe Pro Glu Asp His Ser Gln Pro 
    50                  55                  60                  


Ser Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Ile Glu Arg 
        115                 120         


<210>  754
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v111 (6-127)

<400>  754

Asp Ser Thr Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Asn 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Leu Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Ile Glu Arg 
        115                 120         


<210>  755
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v112 (6-127)

<400>  755

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Thr 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Met Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asn 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Gly Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  756
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v113 (6-127)

<400>  756

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Val Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Ala Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Gln Ala Glu Leu Arg Val Thr Glu Ser 
        115                 120         


<210>  757
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v114 (6-127)

<400>  757

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  758
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v115 (6-127)

<400>  758

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Val Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  759
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v116 (6-127)

<400>  759

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Val Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  760
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD86 WT IgV

<400>  760

Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr 
1               5                   10                  15      


Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln 
            20                  25                  30          


Ser Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln 
        35                  40                  45              


Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His 
    50                  55                  60                  


Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys 
65                  70                  75                  80  


Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser Leu Trp 
                85                  90                  95      


Ala Glu Leu 
            


<210>  761
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v118 (6-127)

<400>  761

Asp Ser Pro Asp Arg Pro Trp Asp Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln His 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Val Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  762
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v119 (6-127)

<400>  762

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Ile Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asp Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  763
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v120 (6-127)

<400>  763

Asp Ser Pro Asp Arg Pro Trp Asp Pro Pro Thr Ile Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Met Asp Lys Leu Ala Ala Phe Pro Glu Asp Ser Asn Gln Pro 
    50                  55                  60                  


Cys Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  764
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v121 (6-127)

<400>  764

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Leu Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Ser Asn Gln Pro 
    50                  55                  60                  


Cys Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  765
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v122 (6-127)

<400>  765

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Gly Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Thr Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Ala Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  766
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v123 (6-127)

<400>  766

Asp Ser Pro Asp Arg Pro Arg Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Ile Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Tyr Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ile Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Val Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Ala Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Gln Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  767
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v124 (6-127)

<400>  767

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Leu Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ile Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Gly Val Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  768
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v125 (6-127)

<400>  768

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Ile Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Ala Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Tyr Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Ile Glu Arg 
        115                 120         


<210>  769
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v126 (6-127)

<400>  769

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Ile Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Leu Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ile Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  770
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v127 (6-127)

<400>  770

Asp Ser Pro Asp Arg Pro Arg Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Val Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  771
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v128, v135 (6-127)

<400>  771

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Ile Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Leu Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ile Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Gly Val Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  772
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v129 (6-127)

<400>  772

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Ile Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Leu Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ile Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  773
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v130 (6-127)

<400>  773

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Gly Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Pro Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ile Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Gly Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Ala Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  774
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v131 (6-127)

<400>  774

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Ile Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Leu Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ile Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Gly Val Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Ile Glu Arg 
        115                 120         


<210>  775
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v132 (6-127)

<400>  775

Asp Ser Pro Val Arg Ala Trp Asp Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Thr Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Met Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Leu Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Ala Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  776
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v133 (6-127)

<400>  776

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Ile Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Ala Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Tyr Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  777
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v134 (6-127)

<400>  777

Asp Ser Pro Glu Arg Pro Trp Asn Pro Pro Thr Ile Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Leu Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ile Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Met Val Arg Ala Arg Arg Asn Asp Ser Gly Ala Tyr 
                85                  90                  95      


Leu Cys Ala Ala Ile Ser Leu Ala Pro Met Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  778
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 WT IgV

<400>  778

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr 
            100     


<210>  779
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v136 (6-127)

<400>  779

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Ile Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Gly Val Val Arg Ala Arg Leu Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Ile Glu Arg 
        115                 120         


<210>  780
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v137 (6-127)

<400>  780

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Ile Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Pro Glu Ser Phe Val Leu Asn Trp Tyr Arg Leu Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ile Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Gly Val Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Met Val Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Gln Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  781
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 12

<400>  781

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ser Pro Asp Arg Pro Trp 
    130                 135                 140                 


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
145                 150                 155                 160 


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
                165                 170                 175     


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
            180                 185                 190         


Ala Phe Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg 
        195                 200                 205             


Val Thr Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Asp Arg 
    210                 215                 220                 


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu 
225                 230                 235                 240 


Ala Pro Lys Val Gln Ile Asp Glu Ser Leu Arg Val Glu Leu Arg Val 
                245                 250                 255     


Thr Glu Arg Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly 
    


<210>  782
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 13

<400>  782

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ser Pro Asp Arg Pro Trp 
    130                 135                 140                 


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
145                 150                 155                 160 


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
                165                 170                 175     


Leu Asn Trp Tyr Arg Met Ser Leu Asn Asn Gln Thr Asp Lys Leu Ala 
            180                 185                 190         


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg 
        195                 200                 205             


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
    210                 215                 220                 


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
225                 230                 235                 240 


Ala Pro Lys Val Gln Ile Lys Asp Ser Leu Trp Ala Glu Leu Arg Val 
                245                 250                 255     


Thr Glu Arg Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly 
    


<210>  783
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 14

<400>  783

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ser Pro Asp Arg Pro Trp 
    130                 135                 140                 


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
145                 150                 155                 160 


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
                165                 170                 175     


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
            180                 185                 190         


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Arg Asp Arg Arg Phe Arg 
        195                 200                 205             


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
    210                 215                 220                 


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
225                 230                 235                 240 


Ala Pro Lys Val Gln Ile Asn Glu Ser Leu Leu Val Glu Leu Arg Val 
                245                 250                 255     


Thr Glu Arg Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly 
    


<210>  784
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 15

<400>  784

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Leu Ser Ser Leu Glu His Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ser Pro Asp Arg Pro Trp 
    130                 135                 140                 


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
145                 150                 155                 160 


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
                165                 170                 175     


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
            180                 185                 190         


Ala Phe Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg 
        195                 200                 205             


Val Thr Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Asp Arg 
    210                 215                 220                 


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu 
225                 230                 235                 240 


Ala Pro Lys Val Gln Ile Asp Glu Ser Leu Arg Val Glu Leu Arg Val 
                245                 250                 255     


Thr Glu Arg Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly 
    


<210>  785
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 16

<400>  785

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Leu Ser Ser Leu Glu His Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ser Pro Asp Arg Pro Trp 
    130                 135                 140                 


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
145                 150                 155                 160 


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
                165                 170                 175     


Leu Asn Trp Tyr Arg Met Ser Leu Asn Asn Gln Thr Asp Lys Leu Ala 
            180                 185                 190         


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg 
        195                 200                 205             


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
    210                 215                 220                 


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
225                 230                 235                 240 


Ala Pro Lys Val Gln Ile Lys Asp Ser Leu Trp Ala Glu Leu Arg Val 
                245                 250                 255     


Thr Glu Arg Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly 
    


<210>  786
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 17

<400>  786

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Leu Ser Ser Leu Glu His Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ser Pro Asp Arg Pro Trp 
    130                 135                 140                 


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
145                 150                 155                 160 


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
                165                 170                 175     


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
            180                 185                 190         


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Arg Asp Arg Arg Phe Arg 
        195                 200                 205             


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
    210                 215                 220                 


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
225                 230                 235                 240 


Ala Pro Lys Val Gln Ile Asn Glu Ser Leu Leu Val Glu Leu Arg Val 
                245                 250                 255     


Thr Glu Arg Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly 
    


<210>  787
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 18

<400>  787

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    130                 135                 140                 


Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
145                 150                 155                 160 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                165                 170                 175     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            180                 185                 190         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        195                 200                 205             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    210                 215                 220                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
225                 230                 235                 240 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                245                 250                 255     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
            260                 265                 270         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        275                 280                 285             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    290                 295                 300                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
305                 310                 315                 320 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                325                 330                 335     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            340                 345                 350         


Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Gly Ser Asp Ser Pro Asp Arg Pro Trp Asn Pro 
    370                 375                 380                 


Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
385                 390                 395                 400 


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
                405                 410                 415     


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
            420                 425                 430         


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
        435                 440                 445             


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Asp Arg Ala Arg 
    450                 455                 460                 


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
465                 470                 475                 480 


Lys Val Gln Ile Asp Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu 
                485                 490                 495     


Arg 
    


<210>  788
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 19

<400>  788

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    130                 135                 140                 


Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
145                 150                 155                 160 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                165                 170                 175     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            180                 185                 190         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        195                 200                 205             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    210                 215                 220                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
225                 230                 235                 240 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                245                 250                 255     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
            260                 265                 270         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        275                 280                 285             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    290                 295                 300                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
305                 310                 315                 320 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                325                 330                 335     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            340                 345                 350         


Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Gly Ser Asp Ser Pro Asp Arg Pro Trp Asn Pro 
    370                 375                 380                 


Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
385                 390                 395                 400 


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
                405                 410                 415     


Trp Tyr Arg Met Ser Leu Asn Asn Gln Thr Asp Lys Leu Ala Ala Phe 
            420                 425                 430         


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr 
        435                 440                 445             


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
    450                 455                 460                 


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
465                 470                 475                 480 


Lys Val Gln Ile Lys Asp Ser Leu Trp Ala Glu Leu Arg Val Thr Glu 
                485                 490                 495     


Arg 
    


<210>  789
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 20

<400>  789

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    130                 135                 140                 


Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
145                 150                 155                 160 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                165                 170                 175     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            180                 185                 190         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        195                 200                 205             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    210                 215                 220                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
225                 230                 235                 240 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                245                 250                 255     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
            260                 265                 270         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        275                 280                 285             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    290                 295                 300                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
305                 310                 315                 320 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                325                 330                 335     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            340                 345                 350         


Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Gly Ser Asp Ser Pro Asp Arg Pro Trp Asn Pro 
    370                 375                 380                 


Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
385                 390                 395                 400 


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
                405                 410                 415     


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
            420                 425                 430         


Pro Glu Asp Arg Ser Gln Pro Gly Arg Asp Arg Arg Phe Arg Val Thr 
        435                 440                 445             


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
    450                 455                 460                 


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
465                 470                 475                 480 


Lys Val Gln Ile Asn Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu 
                485                 490                 495     


Arg 
    


<210>  790
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 21

<400>  790

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Leu Ser Ser Leu Glu His Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    130                 135                 140                 


Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
145                 150                 155                 160 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                165                 170                 175     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            180                 185                 190         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        195                 200                 205             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    210                 215                 220                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
225                 230                 235                 240 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                245                 250                 255     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
            260                 265                 270         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        275                 280                 285             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    290                 295                 300                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
305                 310                 315                 320 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                325                 330                 335     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            340                 345                 350         


Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Gly Ser Asp Ser Pro Asp Arg Pro Trp Asn Pro 
    370                 375                 380                 


Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
385                 390                 395                 400 


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
                405                 410                 415     


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
            420                 425                 430         


Pro Glu Asp Arg Asn Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
        435                 440                 445             


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Asp Arg Ala Arg 
    450                 455                 460                 


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
465                 470                 475                 480 


Lys Val Gln Ile Asp Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu 
                485                 490                 495     


Arg 
    


<210>  791
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 22

<400>  791

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Leu Ser Ser Leu Glu His Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    130                 135                 140                 


Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
145                 150                 155                 160 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                165                 170                 175     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            180                 185                 190         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        195                 200                 205             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    210                 215                 220                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
225                 230                 235                 240 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                245                 250                 255     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
            260                 265                 270         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        275                 280                 285             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    290                 295                 300                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
305                 310                 315                 320 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                325                 330                 335     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            340                 345                 350         


Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Gly Ser Asp Ser Pro Asp Arg Pro Trp Asn Pro 
    370                 375                 380                 


Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
385                 390                 395                 400 


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
                405                 410                 415     


Trp Tyr Arg Met Ser Leu Asn Asn Gln Thr Asp Lys Leu Ala Ala Phe 
            420                 425                 430         


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr 
        435                 440                 445             


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
    450                 455                 460                 


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
465                 470                 475                 480 


Lys Val Gln Ile Lys Asp Ser Leu Trp Ala Glu Leu Arg Val Thr Glu 
                485                 490                 495     


Arg 
    


<210>  792
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 23

<400>  792

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Leu Ser Ser Leu Glu His Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    130                 135                 140                 


Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
145                 150                 155                 160 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                165                 170                 175     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            180                 185                 190         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        195                 200                 205             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    210                 215                 220                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
225                 230                 235                 240 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                245                 250                 255     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
            260                 265                 270         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        275                 280                 285             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    290                 295                 300                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
305                 310                 315                 320 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                325                 330                 335     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            340                 345                 350         


Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Gly Ser Asp Ser Pro Asp Arg Pro Trp Asn Pro 
    370                 375                 380                 


Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
385                 390                 395                 400 


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
                405                 410                 415     


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
            420                 425                 430         


Pro Glu Asp Arg Ser Gln Pro Gly Arg Asp Arg Arg Phe Arg Val Thr 
        435                 440                 445             


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
    450                 455                 460                 


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
465                 470                 475                 480 


Lys Val Gln Ile Asn Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu 
                485                 490                 495     


Arg 
    


<210>  793
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 24

<400>  793

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Asp Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Thr Gln Glu Lys Glu Val 
    130                 135                 140                 


Arg Ala Met Val Gly Ser Asp Val Glu Leu Ser Cys Ala Cys Pro Glu 
145                 150                 155                 160 


Gly Ser Arg Phe Asp Leu Asn Asp Val Tyr Val Tyr Trp Gln Thr Ser 
                165                 170                 175     


Glu Ser Lys Thr Val Val Thr Tyr His Ile Pro Gln His Ser Ser Leu 
            180                 185                 190         


Glu Asn Val Asp Ser Arg Tyr Arg Asn Arg Ala Leu Met Ser Pro Ala 
        195                 200                 205             


Gly Met Leu Arg Gly Asp Phe Ser Leu Arg Leu Phe Asn Val Thr Pro 
    210                 215                 220                 


Gln Asp Glu Gln Lys Phe His Cys Leu Val Leu Ser Arg Ser Leu Gly 
225                 230                 235                 240 


Phe Gln Glu Val Leu Ser Val Glu Val Thr Leu His Val Ala Ala Asn 
                245                 250                 255     


Phe Ser Val Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly 
    


<210>  794
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 25

<400>  794

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Leu Asn 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Asp Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Thr Gln Glu Lys Glu Val 
    130                 135                 140                 


Arg Ala Met Val Gly Ser Asp Val Glu Leu Ser Cys Ala Cys Pro Glu 
145                 150                 155                 160 


Gly Ser Arg Phe Asp Leu Asn Asp Val Tyr Val Tyr Trp Gln Thr Ser 
                165                 170                 175     


Glu Ser Lys Thr Val Val Thr Tyr His Ile Pro Gln His Ser Ser Leu 
            180                 185                 190         


Glu Asn Val Asp Ser Arg Tyr Arg Asn Arg Ala Leu Met Ser Pro Ala 
        195                 200                 205             


Gly Met Leu Arg Gly Asp Phe Ser Leu Arg Leu Phe Asn Val Thr Pro 
    210                 215                 220                 


Gln Asp Glu Gln Lys Phe His Cys Leu Val Leu Ser Arg Ser Leu Gly 
225                 230                 235                 240 


Phe Gln Glu Val Leu Ser Val Glu Val Thr Leu His Val Ala Ala Asn 
                245                 250                 255     


Phe Ser Val Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly 
    


<210>  795
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 26

<400>  795

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Arg Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Thr Gln Glu Lys Glu Val 
    130                 135                 140                 


Arg Ala Met Val Gly Ser Asp Val Glu Leu Ser Cys Ala Cys Pro Glu 
145                 150                 155                 160 


Gly Ser Arg Phe Asp Leu Asn Asp Val Tyr Val Tyr Trp Gln Thr Ser 
                165                 170                 175     


Glu Ser Lys Thr Val Val Thr Tyr His Ile Pro Gln His Ser Ser Leu 
            180                 185                 190         


Glu Asn Val Asp Ser Arg Tyr Arg Asn Arg Ala Leu Met Ser Pro Ala 
        195                 200                 205             


Gly Met Leu Arg Gly Asp Phe Ser Leu Arg Leu Phe Asn Val Thr Pro 
    210                 215                 220                 


Gln Asp Glu Gln Lys Phe His Cys Leu Val Leu Ser Arg Ser Leu Gly 
225                 230                 235                 240 


Phe Gln Glu Val Leu Ser Val Glu Val Thr Leu His Val Ala Ala Asn 
                245                 250                 255     


Phe Ser Val Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly 
    


<210>  796
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 27

<400>  796

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Asp Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Thr Gln Glu Lys Glu Val 
    130                 135                 140                 


Arg Ala Met Val Gly Ser Asp Val Glu Leu Ser Cys Ala Cys Pro Glu 
145                 150                 155                 160 


Gly Ser Arg Phe Asp Leu Asn Asp Val Tyr Val Tyr Trp Gln Thr Ser 
                165                 170                 175     


Glu Ser Lys Thr Val Val Thr Tyr His Ile Pro Gln Leu Ser Ser Leu 
            180                 185                 190         


Glu His Val Asp Ser Arg Tyr Arg Asn Arg Ala Leu Met Ser Pro Ala 
        195                 200                 205             


Gly Met Leu Arg Gly Asp Phe Ser Leu Arg Leu Phe Asn Val Thr Pro 
    210                 215                 220                 


Gln Asp Glu Gln Lys Phe His Cys Leu Val Leu Ser Arg Ser Leu Gly 
225                 230                 235                 240 


Phe Gln Glu Val Leu Ser Val Glu Val Thr Leu His Val Ala Ala Asn 
                245                 250                 255     


Phe Ser Val Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly 
    


<210>  797
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 28

<400>  797

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Leu Asn 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Asp Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Thr Gln Glu Lys Glu Val 
    130                 135                 140                 


Arg Ala Met Val Gly Ser Asp Val Glu Leu Ser Cys Ala Cys Pro Glu 
145                 150                 155                 160 


Gly Ser Arg Phe Asp Leu Asn Asp Val Tyr Val Tyr Trp Gln Thr Ser 
                165                 170                 175     


Glu Ser Lys Thr Val Val Thr Tyr His Ile Pro Gln Leu Ser Ser Leu 
            180                 185                 190         


Glu His Val Asp Ser Arg Tyr Arg Asn Arg Ala Leu Met Ser Pro Ala 
        195                 200                 205             


Gly Met Leu Arg Gly Asp Phe Ser Leu Arg Leu Phe Asn Val Thr Pro 
    210                 215                 220                 


Gln Asp Glu Gln Lys Phe His Cys Leu Val Leu Ser Arg Ser Leu Gly 
225                 230                 235                 240 


Phe Gln Glu Val Leu Ser Val Glu Val Thr Leu His Val Ala Ala Asn 
                245                 250                 255     


Phe Ser Val Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly 
    


<210>  798
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 29

<400>  798

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Arg Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Thr Gln Glu Lys Glu Val 
    130                 135                 140                 


Arg Ala Met Val Gly Ser Asp Val Glu Leu Ser Cys Ala Cys Pro Glu 
145                 150                 155                 160 


Gly Ser Arg Phe Asp Leu Asn Asp Val Tyr Val Tyr Trp Gln Thr Ser 
                165                 170                 175     


Glu Ser Lys Thr Val Val Thr Tyr His Ile Pro Gln Leu Ser Ser Leu 
            180                 185                 190         


Glu His Val Asp Ser Arg Tyr Arg Asn Arg Ala Leu Met Ser Pro Ala 
        195                 200                 205             


Gly Met Leu Arg Gly Asp Phe Ser Leu Arg Leu Phe Asn Val Thr Pro 
    210                 215                 220                 


Gln Asp Glu Gln Lys Phe His Cys Leu Val Leu Ser Arg Ser Leu Gly 
225                 230                 235                 240 


Phe Gln Glu Val Leu Ser Val Glu Val Thr Leu His Val Ala Ala Asn 
                245                 250                 255     


Phe Ser Val Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly 
    


<210>  799
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 30

<400>  799

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Asp Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    130                 135                 140                 


Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
145                 150                 155                 160 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                165                 170                 175     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            180                 185                 190         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        195                 200                 205             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    210                 215                 220                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
225                 230                 235                 240 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                245                 250                 255     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
            260                 265                 270         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        275                 280                 285             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    290                 295                 300                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
305                 310                 315                 320 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                325                 330                 335     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            340                 345                 350         


Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Gly Ser Asp Thr Gln Glu Lys Glu Val Arg Ala 
    370                 375                 380                 


Met Val Gly Ser Asp Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser 
385                 390                 395                 400 


Arg Phe Asp Leu Asn Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser 
                405                 410                 415     


Lys Thr Val Val Thr Tyr His Ile Pro Gln His Ser Ser Leu Glu Asn 
            420                 425                 430         


Val Asp Ser Arg Tyr Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met 
        435                 440                 445             


Leu Arg Gly Asp Phe Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp 
    450                 455                 460                 


Glu Gln Lys Phe His Cys Leu Val Leu Ser Arg Ser Leu Gly Phe Gln 
465                 470                 475                 480 


Glu Val Leu Ser Val Glu Val Thr Leu His Val Ala Ala Asn Phe Ser 
                485                 490                 495     


Val 
    


<210>  800
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 31

<400>  800

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Leu Asn 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Asp Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    130                 135                 140                 


Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
145                 150                 155                 160 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                165                 170                 175     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            180                 185                 190         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        195                 200                 205             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    210                 215                 220                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
225                 230                 235                 240 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                245                 250                 255     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
            260                 265                 270         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        275                 280                 285             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    290                 295                 300                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
305                 310                 315                 320 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                325                 330                 335     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            340                 345                 350         


Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Gly Ser Asp Thr Gln Glu Lys Glu Val Arg Ala 
    370                 375                 380                 


Met Val Gly Ser Asp Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser 
385                 390                 395                 400 


Arg Phe Asp Leu Asn Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser 
                405                 410                 415     


Lys Thr Val Val Thr Tyr His Ile Pro Gln His Ser Ser Leu Glu Asn 
            420                 425                 430         


Val Asp Ser Arg Tyr Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met 
        435                 440                 445             


Leu Arg Gly Asp Phe Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp 
    450                 455                 460                 


Glu Gln Lys Phe His Cys Leu Val Leu Ser Arg Ser Leu Gly Phe Gln 
465                 470                 475                 480 


Glu Val Leu Ser Val Glu Val Thr Leu His Val Ala Ala Asn Phe Ser 
                485                 490                 495     


Val 
    


<210>  801
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 32

<400>  801

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Arg Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    130                 135                 140                 


Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
145                 150                 155                 160 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                165                 170                 175     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            180                 185                 190         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        195                 200                 205             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    210                 215                 220                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
225                 230                 235                 240 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                245                 250                 255     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
            260                 265                 270         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        275                 280                 285             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    290                 295                 300                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
305                 310                 315                 320 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                325                 330                 335     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            340                 345                 350         


Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Gly Ser Asp Thr Gln Glu Lys Glu Val Arg Ala 
    370                 375                 380                 


Met Val Gly Ser Asp Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser 
385                 390                 395                 400 


Arg Phe Asp Leu Asn Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser 
                405                 410                 415     


Lys Thr Val Val Thr Tyr His Ile Pro Gln His Ser Ser Leu Glu Asn 
            420                 425                 430         


Val Asp Ser Arg Tyr Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met 
        435                 440                 445             


Leu Arg Gly Asp Phe Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp 
    450                 455                 460                 


Glu Gln Lys Phe His Cys Leu Val Leu Ser Arg Ser Leu Gly Phe Gln 
465                 470                 475                 480 


Glu Val Leu Ser Val Glu Val Thr Leu His Val Ala Ala Asn Phe Ser 
                485                 490                 495     


Val 
    


<210>  802
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 33

<400>  802

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Asp Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    130                 135                 140                 


Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
145                 150                 155                 160 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                165                 170                 175     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            180                 185                 190         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        195                 200                 205             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    210                 215                 220                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
225                 230                 235                 240 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                245                 250                 255     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
            260                 265                 270         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        275                 280                 285             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    290                 295                 300                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
305                 310                 315                 320 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                325                 330                 335     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            340                 345                 350         


Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Gly Ser Asp Thr Gln Glu Lys Glu Val Arg Ala 
    370                 375                 380                 


Met Val Gly Ser Asp Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser 
385                 390                 395                 400 


Arg Phe Asp Leu Asn Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser 
                405                 410                 415     


Lys Thr Val Val Thr Tyr His Ile Pro Gln Leu Ser Ser Leu Glu His 
            420                 425                 430         


Val Asp Ser Arg Tyr Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met 
        435                 440                 445             


Leu Arg Gly Asp Phe Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp 
    450                 455                 460                 


Glu Gln Lys Phe His Cys Leu Val Leu Ser Arg Ser Leu Gly Phe Gln 
465                 470                 475                 480 


Glu Val Leu Ser Val Glu Val Thr Leu His Val Ala Ala Asn Phe Ser 
                485                 490                 495     


Val 
    


<210>  803
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 34

<400>  803

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Leu Asn 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Lys Asp Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    130                 135                 140                 


Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
145                 150                 155                 160 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                165                 170                 175     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            180                 185                 190         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        195                 200                 205             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    210                 215                 220                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
225                 230                 235                 240 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                245                 250                 255     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
            260                 265                 270         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        275                 280                 285             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    290                 295                 300                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
305                 310                 315                 320 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                325                 330                 335     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            340                 345                 350         


Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Gly Ser Asp Thr Gln Glu Lys Glu Val Arg Ala 
    370                 375                 380                 


Met Val Gly Ser Asp Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser 
385                 390                 395                 400 


Arg Phe Asp Leu Asn Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser 
                405                 410                 415     


Lys Thr Val Val Thr Tyr His Ile Pro Gln Leu Ser Ser Leu Glu His 
            420                 425                 430         


Val Asp Ser Arg Tyr Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met 
        435                 440                 445             


Leu Arg Gly Asp Phe Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp 
    450                 455                 460                 


Glu Gln Lys Phe His Cys Leu Val Leu Ser Arg Ser Leu Gly Phe Gln 
465                 470                 475                 480 


Glu Val Leu Ser Val Glu Val Thr Leu His Val Ala Ala Asn Phe Ser 
                485                 490                 495     


Val 
    


<210>  804
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL/PD-1 Stack 35

<400>  804

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Arg Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    130                 135                 140                 


Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
145                 150                 155                 160 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                165                 170                 175     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            180                 185                 190         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        195                 200                 205             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    210                 215                 220                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
225                 230                 235                 240 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                245                 250                 255     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
            260                 265                 270         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        275                 280                 285             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    290                 295                 300                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
305                 310                 315                 320 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                325                 330                 335     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            340                 345                 350         


Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Gly Ser Asp Thr Gln Glu Lys Glu Val Arg Ala 
    370                 375                 380                 


Met Val Gly Ser Asp Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser 
385                 390                 395                 400 


Arg Phe Asp Leu Asn Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser 
                405                 410                 415     


Lys Thr Val Val Thr Tyr His Ile Pro Gln Leu Ser Ser Leu Glu His 
            420                 425                 430         


Val Asp Ser Arg Tyr Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met 
        435                 440                 445             


Leu Arg Gly Asp Phe Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp 
    450                 455                 460                 


Glu Gln Lys Phe His Cys Leu Val Leu Ser Arg Ser Leu Gly Phe Gln 
465                 470                 475                 480 


Glu Val Leu Ser Val Glu Val Thr Leu His Val Ala Ala Asn Phe Ser 
                485                 490                 495     


Val 
    


<210>  805
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL WT IgV

<400>  805

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  806
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL WT IgV

<400>  806

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu 
            100                 105                 110     


<210>  807
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL variant IgV

<400>  807

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  808
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL variant IgV

<400>  808

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  809
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL variant IgV

<400>  809

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Leu Ser Ser Leu Glu His Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Arg Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  810
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOSL variant IgV

<400>  810

Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu 
1               5                   10                  15      


Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val 
            20                  25                  30          


Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His 
        35                  40                  45              


Ile Pro Gln Ser Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn 
    50                  55                  60                  


Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu 
65                  70                  75                  80  


Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu 
                85                  90                  95      


Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val 
            100                 105                 110         


Thr Leu His Val Ala Ala Asn Phe Ser Val 
        115                 120         


<210>  811
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v202 (6-127)

<400>  811

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ala Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Gln Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  812
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v203 (6-127)

<400>  812

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Gly Ile Thr Leu Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  813
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v204 (6-127)

<400>  813

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


His Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Glu Gln Asp Pro Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  814
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v205 (6-127)

<400>  814

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Gly Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Gln Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  815
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v206 (6-127)

<400>  815

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Ser Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Gly Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  816
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v207 (6-127)

<400>  816

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Trp Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  817
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v208 (6-127)

<400>  817

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Glu Gln Asp Pro Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Glu Glu Ser 
            100                 105                 110         


Leu Gln Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  818
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v209 (6-127)

<400>  818

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Gly Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Gly Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Trp Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  819
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v210 (6-127)

<400>  819

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Gly Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  820
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v211 (6-127)

<400>  820

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  821
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v212 (6-127)

<400>  821

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Val Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Gly Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Ala Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Trp Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  822
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v213 (6-127)

<400>  822

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Pro Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Gln Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  823
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v214 (6-127)

<400>  823

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Glu Glu Ser 
            100                 105                 110         


Leu Gln Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  824
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v215 (6-127)

<400>  824

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Thr Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Glu Glu Ser 
            100                 105                 110         


Leu Trp Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  825
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v216 (6-127)

<400>  825

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Arg Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  826
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v217 (6-127)

<400>  826

Asp Ser Pro Asp Arg Pro Trp Asn Leu Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Gly Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  827
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v218 (6-127)

<400>  827

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Glu Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  828
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v219 (6-127)

<400>  828

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Gly Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Val Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  829
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v220 (6-127)

<400>  829

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Ser Ala Ile Thr Phe Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  830
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v221 (6-127)

<400>  830

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  831
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v222 (6-127)

<400>  831

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  832
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v223 (6-127)

<400>  832

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Arg Ile Asp Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  833
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v224 (6-127)

<400>  833

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Ala Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  834
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v225 (6-127)

<400>  834

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Glu Gln Asp Pro Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Gly Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Gln Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  835
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v226 (6-127)

<400>  835

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Gly Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Gly Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  836
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v227 (6-127)

<400>  836

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Gly Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Gly Ile Thr Leu Ala Pro Lys Val Arg Ile Asp Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  837
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v228 (6-127)

<400>  837

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Gln Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  838
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v229 (6-127)

<400>  838

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  839
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v230 (6-127)

<400>  839

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ala Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Arg Ile Glu Glu Ser 
            100                 105                 110         


Leu Gln Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  840
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v231 (6-127)

<400>  840

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Gln Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  841
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v232 (6-127)

<400>  841

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Gly Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Trp Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  842
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v233 (6-127)

<400>  842

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Pro Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Gly Ile Thr Leu Ala Pro Lys Val Arg Ile Asp Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  843
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v234 (6-127)

<400>  843

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Gly Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  844
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v235 (6-127)

<400>  844

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ala Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  845
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v236 (6-127)

<400>  845

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Ser 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Trp Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  846
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v237 (6-127)

<400>  846

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Ser Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Glu Glu Ser 
            100                 105                 110         


Leu Trp Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  847
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v238 (6-127)

<400>  847

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Arg Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Gln Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  848
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v239 (6-127)

<400>  848

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Gln Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  849
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v240 (6-127)

<400>  849

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Glu Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Gln Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  850
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v241 (6-127)

<400>  850

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Trp Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  851
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v242 (6-127)

<400>  851

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Glu Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Thr Ala Leu Thr Thr Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  852
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v243 (6-127)

<400>  852

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp His Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Gly Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  853
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v244 (6-127)

<400>  853

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Glu Gln Asp Pro Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Cys Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  854
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v245 (6-127)

<400>  854

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Glu Gln Asp Pro Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Gln Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  855
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v246 (6-127)

<400>  855

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Arg Val Gln Ile Glu Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  856
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v247 (6-127)

<400>  856

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Gly 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Gly Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Gln Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  857
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v248 (6-127)

<400>  857

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Glu Glu Ser 
            100                 105                 110         


Leu Trp Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  858
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v249 (6-127)

<400>  858

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Ser Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Gly Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Glu Glu Ser 
            100                 105                 110         


Leu Gln Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  859
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v250 (6-127)

<400>  859

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Ser Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  860
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v251 (6-127)

<400>  860

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Leu Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Arg Asp Gly Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Gly Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  861
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v252 (6-127)

<400>  861

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Gly Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Glu Glu Ser 
            100                 105                 110         


Leu Trp Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  862
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v253 (6-127)

<400>  862

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Glu Gln Asp Gly Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Cys Ile Thr Leu Ala Pro Lys Val Gln Ile Glu Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  863
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v254 (6-127)

<400>  863

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Gly Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Ala Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Trp Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  864
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v255 (6-127)

<400>  864

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  865
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v256 (6-127)

<400>  865

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Pro Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Leu Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  866
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v257 (6-127)

<400>  866

Asp Ser Pro Asp Arg Pro Arg Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Gln Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  867
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v258 (6-127)

<400>  867

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Glu Gln Asp Gly Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Leu Ile Ser Leu Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Gln Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  868
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v259 (6-127)

<400>  868

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asn Glu Ser 
            100                 105                 110         


Leu Trp Val Glu Leu Arg Val Thr Glu Arg 
        115                 120         


<210>  869
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v202 (1-150)

<400>  869

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Ala Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Gln Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  870
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v203 (1-150)

<400>  870

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Gly Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  871
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v204 (1-150)

<400>  871

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser His Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Glu Gln Asp Pro Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  872
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v205 (1-150)

<400>  872

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Gly Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Gln Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  873
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v206 (1-150)

<400>  873

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Ser Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Gly Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  874
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v207 (1-150)

<400>  874

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asp Glu Ser Leu Trp Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  875
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v208 (1-150)

<400>  875

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Glu Gln Asp Pro Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Glu Glu Ser Leu Gln Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  876
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v209 (1-150)

<400>  876

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Gly Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Gly Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asp Glu Ser Leu Trp Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  877
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v210 (1-150)

<400>  877

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Gly Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  878
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v211 (1-150)

<400>  878

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  879
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v212 (1-150)

<400>  879

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Val Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Gly Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Trp Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  880
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v213 (1-150)

<400>  880

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Pro Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asp Glu Ser Leu Gln Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  881
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v214 (1-150)

<400>  881

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Glu Glu Ser Leu Gln Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  882
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v215 (1-150)

<400>  882

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Thr Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Glu Glu Ser Leu Trp Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  883
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v216 (1-150)

<400>  883

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Arg Val 
            100                 105                 110         


Gln Ile Asp Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  884
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v217 (1-150)

<400>  884

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Leu Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Gly Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  885
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v218 (1-150)

<400>  885

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Glu Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  886
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v219 (1-150)

<400>  886

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Gly Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Val Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  887
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v220 (1-150)

<400>  887

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Ser Ala Ile Thr Phe Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  888
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v221 (1-150)

<400>  888

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asp Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  889
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v222 (1-150)

<400>  889

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  890
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v223 (1-150)

<400>  890

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Arg Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  891
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v224 (1-150)

<400>  891

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Ala Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  892
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v225 (1-150)

<400>  892

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Glu Gln Asp Pro Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Gly Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asp Glu Ser Leu Gln Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  893
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v226 (1-150)

<400>  893

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Gly Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Gly Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  894
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v227 (1-150)

<400>  894

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Gly Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Gly Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Arg Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  895
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v228 (1-150)

<400>  895

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asp Glu Ser Leu Gln Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  896
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v229 (1-150)

<400>  896

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  897
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v230 (1-150)

<400>  897

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Ala Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Arg Ile Glu Glu Ser Leu Gln Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  898
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v231 (1-150)

<400>  898

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asp Glu Ser Leu Gln Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  899
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v232 (1-150)

<400>  899

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Gly Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asp Glu Ser Leu Trp Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  900
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v233 (1-150)

<400>  900

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Pro Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Gly Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Arg Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  901
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v234 (1-150)

<400>  901

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Gly Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  902
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v235 (1-150)

<400>  902

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Ala Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  903
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v236 (1-150)

<400>  903

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Ser Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asp Glu Ser Leu Trp Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  904
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v237 (1-150)

<400>  904

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Ser Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Glu Glu Ser Leu Trp Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  905
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v238 (1-150)

<400>  905

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Arg Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asp Glu Ser Leu Gln Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  906
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v239 (1-150)

<400>  906

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Gln Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  907
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v240 (1-150)

<400>  907

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Glu Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Gln Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  908
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v241 (1-150)

<400>  908

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asp Glu Ser Leu Trp Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  909
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v242 (1-150)

<400>  909

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Glu Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Thr Ala Leu Thr Thr Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  910
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v243 (1-150)

<400>  910

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp His Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Gly Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  911
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v244 (1-150)

<400>  911

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Glu Gln Asp Pro Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Cys Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  912
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v245 (1-150)

<400>  912

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Glu Gln Asp Pro Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asp Glu Ser Leu Gln Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  913
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v246 (1-150)

<400>  913

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Arg Val 
            100                 105                 110         


Gln Ile Glu Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  914
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v247 (1-150)

<400>  914

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Gly Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Gly Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asp Glu Ser Leu Gln Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  915
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v248 (1-150)

<400>  915

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Glu Glu Ser Leu Trp Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  916
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v249 (1-150)

<400>  916

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Ser Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Gly Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Glu Glu Ser Leu Gln Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  917
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v250 (1-150)

<400>  917

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Ser Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  918
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v251 (1-150)

<400>  918

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Leu Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Arg Asp Gly Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Gly Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  919
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v252 (1-150)

<400>  919

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Gly Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Glu Glu Ser Leu Trp Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  920
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v253 (1-150)

<400>  920

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Glu Gln Asp Gly Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Cys Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Glu Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  921
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v254 (1-150)

<400>  921

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Gly Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asp Glu Ser Leu Trp Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  922
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v255 (1-150)

<400>  922

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Arg Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  923
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v256 (1-150)

<400>  923

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Pro Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Leu Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  924
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v257 (1-150)

<400>  924

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Arg Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asp Glu Ser Leu Gln Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  925
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v258 (1-150)

<400>  925

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Glu Gln Asp Gly Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Leu Ile Ser Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Gln Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  926
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v259 (1-150)

<400>  926

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val 
            100                 105                 110         


Gln Ile Asn Glu Ser Leu Trp Val Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  927
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v202 (15-125)

<400>  927

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ala Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asn Glu Ser Leu Gln Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  928
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v203 (15-125)

<400>  928

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Gly Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asn Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  929
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v204 (15-125)

<400>  929

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser His Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Glu Gln Asp Pro Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  930
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v205 (15-125)

<400>  930

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Gly Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asn Glu Ser Leu Gln Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  931
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v206 (15-125)

<400>  931

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Ser Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Gly Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  932
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v207 (15-125)

<400>  932

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asp Glu Ser Leu Trp Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  933
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v208 (15-125)

<400>  933

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Glu Gln Asp Pro Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Glu Glu Ser Leu Gln Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  934
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v209 (15-125)

<400>  934

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Gly Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Gly Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asp Glu Ser Leu Trp Ala Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  935
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v210,v217 (15-125)

<400>  935

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Gly Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  936
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v211 (15-125)

<400>  936

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  937
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v212 (15-125)

<400>  937

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Val Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Gly Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asn Glu Ser Leu Trp Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  938
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v213 (15-125)

<400>  938

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Pro Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asp Glu Ser Leu Gln Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  939
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v214 (15-125)

<400>  939

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Glu Glu Ser Leu Gln Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  940
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v215 (15-125)

<400>  940

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Thr Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Glu Glu Ser Leu Trp Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  941
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v216 (15-125)

<400>  941

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Arg Val Gln Ile Asp Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  942
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v258 (15-125)

<400>  942

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Glu Gln Asp Gly Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Leu Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asn Glu Ser Leu Gln Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  943
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v218 (15-125)

<400>  943

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Glu Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  944
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v219 (15-125)

<400>  944

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Gly Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Val Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asn Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  945
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v220 (15-125)

<400>  945

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Ser Ala Ile Thr Phe Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  946
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v221 (15-125)

<400>  946

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asp Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  947
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v222 (15-125)

<400>  947

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  948
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v223 (15-125)

<400>  948

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Arg Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  949
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v224 (15-125)

<400>  949

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Ala Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  950
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v225 (15-125)

<400>  950

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Glu Gln Asp Pro Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Gly Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asp Glu Ser Leu Gln Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  951
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v226 (15-125)

<400>  951

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Gly Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Gly Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  952
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v227 (15-125)

<400>  952

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Gly Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Gly Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Arg Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  953
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v228, v257 (15-125)

<400>  953

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asp Glu Ser Leu Gln Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  954
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v229 (15-125)

<400>  954

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asn Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  955
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v230 (15-125)

<400>  955

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ala Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Arg Ile Glu Glu Ser Leu Gln Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  956
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v231 (15-125)

<400>  956

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asp Glu Ser Leu Gln Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  957
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v232 (15-125)

<400>  957

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Gly Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asp Glu Ser Leu Trp Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  958
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v233 (15-125)

<400>  958

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Pro Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Gly Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Arg Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  959
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v234 (15-125)

<400>  959

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Gly Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  960
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v235 (15-125)

<400>  960

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ala Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  961
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v236 (15-125)

<400>  961

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Ser Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asp Glu Ser Leu Trp Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  962
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v237 (15-125)

<400>  962

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Ser Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Glu Glu Ser Leu Trp Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  963
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v238 (15-125)

<400>  963

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Arg Pro Gly Gln Asp Ser Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asp Glu Ser Leu Gln Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  964
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v239 (15-125)

<400>  964

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asn Glu Ser Leu Gln Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  965
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v240 (15-125)

<400>  965

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Glu Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asn Glu Ser Leu Gln Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  966
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v241 (15-125)

<400>  966

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asp Glu Ser Leu Trp Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  967
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v242 (15-125)

<400>  967

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Glu Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Thr Ala Leu Thr Thr Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asn Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  968
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v243 (15-125)

<400>  968

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp His Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Gly Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  969
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v244 (15-125)

<400>  969

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Glu Gln Asp Pro Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Cys Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  970
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v245 (15-125)

<400>  970

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Glu Gln Asp Pro Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asp Glu Ser Leu Gln Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  971
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v246 (15-125)

<400>  971

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Arg Val Gln Ile Glu Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  972
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v247 (15-125)

<400>  972

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Gly Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Gly Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asp Glu Ser Leu Gln Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  973
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v248 (15-125)

<400>  973

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Arg Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Glu Glu Ser Leu Trp Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  974
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v249 (15-125)

<400>  974

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Ser Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Gly Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Glu Glu Ser Leu Gln Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  975
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v250 (15-125)

<400>  975

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Ser Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asn Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  976
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v251 (15-125)

<400>  976

Pro Thr Leu Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Arg Asp Gly Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Gly Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asp Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  977
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v252 (15-125)

<400>  977

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Gly Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Glu Glu Ser Leu Trp Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  978
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v253 (15-125)

<400>  978

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Glu Gln Asp Gly Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Cys Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Glu Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  979
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v254 (15-125)

<400>  979

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Gly Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Ala Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asp Glu Ser Leu Trp Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  980
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v255 (15-125)

<400>  980

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asn Glu Ser Leu Arg Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  981
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v256 (15-125)

<400>  981

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Pro Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asn Glu Ser Leu Leu Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  982
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v259 (15-125)

<400>  982

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Tyr His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Thr Leu Ala Pro 
                85                  90                  95      


Lys Val Gln Ile Asn Glu Ser Leu Trp Val Glu Leu Arg Val Thr 
            100                 105                 110     


<210>  983
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 WT IgV

<400>  983

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val 
            100                 


<210>  984
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 WT IgV

<400>  984

Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      


Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          


Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              


Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  


Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  


Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      


Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp 
            100                 105         


<210>  985
<211>  127
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  PD-1(wt 1-127)

<300>
<308>  UniProt/Q15116.3
<309>  2018-09-12
<313>  (1)..(127)

<400>  985

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg 
        115                 120                 125         


<210>  986
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 (C181S) hinge

<400>  986

Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
1               5                   10                  15      


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            20                  25                  30          


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp 
        35                  40                  45              


<210>  987
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 wild-type hinge

<400>  987

Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
1               5                   10                  15      


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            20                  25                  30          


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45              


<210>  988
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 transmembrane domain

<400>  988

Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
1               5                   10                  15      


Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25      


<210>  989
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  41BB transmembrane domain

<400>  989

Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu 
1               5                   10                  15      


Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val 
            20                  25          


<210>  990
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated 4-1BB-derived costimulatory domain

<400>  990

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu 
        35          


<210>  991
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOS transmembrane domain

<400>  991

Phe Trp Leu Pro Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu 
1               5                   10                  15      


Gly Cys Ile Leu Ile 
            20      


<210>  992
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOS intracellular domain

<400>  992

Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn 
1               5                   10                  15      


Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg 
            20                  25                  30          


Leu Thr Asp Val Thr Leu 
        35              


<210>  993
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v201  (vCD8) CD28_CD28

<400>  993

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe His Val Ile Trp His Arg Glu Ser Pro Ser 
        35                  40                  45              


Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Ala Lys Pro Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Ser Asp Trp Val Leu Val Val Val 
                165                 170                 175     


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
            180                 185                 190         


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
        195                 200                 205             


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
    210                 215                 220                 


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
225                 230                 235         


<210>  994
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v201  (vCD8) 41BB_41BB

<400>  994

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe His Val Ile Trp His Arg Glu Ser Pro Ser 
        35                  40                  45              


Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Ala Lys Pro Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Ser Asp Ile Ile Ser Phe Phe Leu 
                165                 170                 175     


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
            180                 185                 190         


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
        195                 200                 205             


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
    210                 215                 220                 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
225                 230                 235                 


<210>  995
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v201  (vCD8) ICOS_ICOS

<400>  995

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe His Val Ile Trp His Arg Glu Ser Pro Ser 
        35                  40                  45              


Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Ala Lys Pro Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Ser Asp Leu Lys Phe Trp Leu Pro 
                165                 170                 175     


Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu 
            180                 185                 190         


Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro 
        195                 200                 205             


Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser 
    210                 215                 220                 


Arg Leu Thr Asp Val Thr Leu 
225                 230     


<210>  996
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v201  (vCD8) CD28_CD28/41BB

<400>  996

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe His Val Ile Trp His Arg Glu Ser Pro Ser 
        35                  40                  45              


Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Ala Lys Pro Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Ser Asp Trp Val Leu Val Val Val 
                165                 170                 175     


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
            180                 185                 190         


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
        195                 200                 205             


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
    210                 215                 220                 


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly 
225                 230                 235                 240 


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
                245                 250                 255     


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
            260                 265                 270         


Glu Glu Gly Gly Cys Glu Leu 
        275                 


<210>  997
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v201  (vCD8) CD28_CD28/ICOS

<400>  997

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe His Val Ile Trp His Arg Glu Ser Pro Ser 
        35                  40                  45              


Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Ala Lys Pro Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Ser Asp Trp Val Leu Val Val Val 
                165                 170                 175     


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
            180                 185                 190         


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
        195                 200                 205             


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
    210                 215                 220                 


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Cys Trp Leu 
225                 230                 235                 240 


Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr 
                245                 250                 255     


Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp 
            260                 265                 270         


Val Thr Leu 
        275 


<210>  998
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v201  (vCD8) 41BB_41BB/CD28

<400>  998

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe His Val Ile Trp His Arg Glu Ser Pro Ser 
        35                  40                  45              


Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Ala Lys Pro Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Ser Asp Ile Ile Ser Phe Phe Leu 
                165                 170                 175     


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
            180                 185                 190         


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
        195                 200                 205             


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
    210                 215                 220                 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
225                 230                 235                 240 


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
                245                 250                 255     


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
            260                 265                 270         


Arg Asp Phe Ala Ala Tyr Arg Ser 
        275                 280 


<210>  999
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v201  (vCD8) 41BB_41BB/ICOS

<400>  999

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe His Val Ile Trp His Arg Glu Ser Pro Ser 
        35                  40                  45              


Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Ala Lys Pro Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Ile Ser Phe Phe Leu 
                165                 170                 175     


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
            180                 185                 190         


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
        195                 200                 205             


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
    210                 215                 220                 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Cys 
225                 230                 235                 240 


Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly 
                245                 250                 255     


Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu 
            260                 265                 270         


Thr Asp Val Thr Leu 
        275         


<210>  1000
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v201  (vCD8) ICOS_ICOS/CD28

<400>  1000

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe His Val Ile Trp His Arg Glu Ser Pro Ser 
        35                  40                  45              


Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Ala Lys Pro Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Ser Asp Phe Trp Leu Pro Ile Gly 
                165                 170                 175     


Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu Ile Cys 
            180                 185                 190         


Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly 
        195                 200                 205             


Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu 
    210                 215                 220                 


Thr Asp Val Thr Leu Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
225                 230                 235                 240 


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
                245                 250                 255     


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            260                 265                 270 


<210>  1001
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v201  (vCD8) ICOS_ICOS/41BB

<400>  1001

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe His Val Ile Trp His Arg Glu Ser Pro Ser 
        35                  40                  45              


Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Ala Lys Pro Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Ser Asp Phe Trp Leu Pro Ile Gly 
                165                 170                 175     


Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu Ile Cys 
            180                 185                 190         


Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly 
        195                 200                 205             


Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu 
    210                 215                 220                 


Thr Asp Val Thr Leu Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
225                 230                 235                 240 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                245                 250                 255     


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            260                 265                 270     


<210>  1002
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v201  (vCD8)CD28_CD28/ICOS/41BB

<400>  1002

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe His Val Ile Trp His Arg Glu Ser Pro Ser 
        35                  40                  45              


Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Ala Lys Pro Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Ser Asp Trp Val Leu Val Val Val 
                165                 170                 175     


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
            180                 185                 190         


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
        195                 200                 205             


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
    210                 215                 220                 


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Cys Trp Leu 
225                 230                 235                 240 


Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr 
                245                 250                 255     


Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp 
            260                 265                 270         


Val Thr Leu Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        275                 280                 285             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    290                 295                 300                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
305                 310                 315         


<210>  1003
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v201  (vCD8)CD28_RSKS

<400>  1003

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe His Val Ile Trp His Arg Glu Ser Pro Ser 
        35                  40                  45              


Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Ala Lys Pro Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Ser Asp Trp Val Leu Val Val Val 
                165                 170                 175     


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
            180                 185                 190         


Ile Phe Trp Val Arg Ser Lys Ser 
        195                 200 


<210>  1004
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 WT  (CD8) CD28_CD28

<400>  1004

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Ala 
        115                 120                 125             


Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
    130                 135                 140                 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
145                 150                 155                 160 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Trp 
                165                 170                 175     


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
            180                 185                 190         


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
        195                 200                 205             


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
    210                 215                 220                 


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
225                 230                 235                 240 


Arg Ser 
        


<210>  1005
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 WT  (CD8) CD28_CD28/41BB

<400>  1005

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Ala 
        115                 120                 125             


Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
    130                 135                 140                 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
145                 150                 155                 160 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Trp 
                165                 170                 175     


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
            180                 185                 190         


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
        195                 200                 205             


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
    210                 215                 220                 


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
225                 230                 235                 240 


Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
                245                 250                 255     


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
            260                 265                 270         


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        275                 280                 


<210>  1006
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 WT  (CD8) CD28_CD28/ICOS

<400>  1006

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Ala 
        115                 120                 125             


Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
    130                 135                 140                 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
145                 150                 155                 160 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Trp 
                165                 170                 175     


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
            180                 185                 190         


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
        195                 200                 205             


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
    210                 215                 220                 


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
225                 230                 235                 240 


Arg Ser Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp 
                245                 250                 255     


Pro Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys 
            260                 265                 270         


Ser Arg Leu Thr Asp Val Thr Leu 
        275                 280 


<210>  1007
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 WT  (CD8) CD28_CD28/ICOS/41BB

<400>  1007

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Ala 
        115                 120                 125             


Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
    130                 135                 140                 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
145                 150                 155                 160 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Trp 
                165                 170                 175     


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
            180                 185                 190         


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
        195                 200                 205             


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
    210                 215                 220                 


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
225                 230                 235                 240 


Arg Ser Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp 
                245                 250                 255     


Pro Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys 
            260                 265                 270         


Ser Arg Leu Thr Asp Val Thr Leu Lys Arg Gly Arg Lys Lys Leu Leu 
        275                 280                 285             


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
    290                 295                 300                 


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
305                 310                 315                 320 


Glu Leu 
        


<210>  1008
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 WT  (CD8) CD28_RSKS

<400>  1008

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Ala 
        115                 120                 125             


Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
    130                 135                 140                 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
145                 150                 155                 160 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Trp 
                165                 170                 175     


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
            180                 185                 190         


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Ser 
        195                 200                 205 


<210>  1009
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 WT  (vCD8) CD28_CD28

<400>  1009

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Ala 
        115                 120                 125             


Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
    130                 135                 140                 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
145                 150                 155                 160 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Trp 
                165                 170                 175     


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
            180                 185                 190         


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
        195                 200                 205             


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
    210                 215                 220                 


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
225                 230                 235                 240 


Arg Ser 
        


<210>  1010
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 WT  (vCD8) CD28_CD28/41BB

<400>  1010

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Ala 
        115                 120                 125             


Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
    130                 135                 140                 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
145                 150                 155                 160 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Trp 
                165                 170                 175     


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
            180                 185                 190         


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
        195                 200                 205             


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
    210                 215                 220                 


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
225                 230                 235                 240 


Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
                245                 250                 255     


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
            260                 265                 270         


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        275                 280                 


<210>  1011
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 WT  (vCD8) CD28_CD28/ICOS

<400>  1011

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Ala 
        115                 120                 125             


Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
    130                 135                 140                 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
145                 150                 155                 160 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Trp 
                165                 170                 175     


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
            180                 185                 190         


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
        195                 200                 205             


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
    210                 215                 220                 


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
225                 230                 235                 240 


Arg Ser Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp 
                245                 250                 255     


Pro Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys 
            260                 265                 270         


Ser Arg Leu Thr Asp Val Thr Leu 
        275                 280 


<210>  1012
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 WT  (vCD8) CD28_CD28/ICOS/41BB

<400>  1012

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Ala 
        115                 120                 125             


Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
    130                 135                 140                 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
145                 150                 155                 160 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Trp 
                165                 170                 175     


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
            180                 185                 190         


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
        195                 200                 205             


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
    210                 215                 220                 


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
225                 230                 235                 240 


Arg Ser Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp 
                245                 250                 255     


Pro Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys 
            260                 265                 270         


Ser Arg Leu Thr Asp Val Thr Leu Lys Arg Gly Arg Lys Lys Leu Leu 
        275                 280                 285             


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
    290                 295                 300                 


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
305                 310                 315                 320 


Glu Leu 
        


<210>  1013
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 WT  (vCD8) CD28_RSKS

<400>  1013

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Ala 
        115                 120                 125             


Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
    130                 135                 140                 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
145                 150                 155                 160 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Trp 
                165                 170                 175     


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
            180                 185                 190         


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Ser 
        195                 200                 205 


<210>  1014
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 WT  (vCD8) CD28_ICOS

<400>  1014

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Ala 
        115                 120                 125             


Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
    130                 135                 140                 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
145                 150                 155                 160 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Trp 
                165                 170                 175     


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
            180                 185                 190         


Thr Val Ala Phe Ile Ile Phe Trp Val Cys Trp Leu Thr Lys Lys Lys 
        195                 200                 205             


Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr Met Phe Met Arg 
    210                 215                 220                 


Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp Val Thr Leu 
225                 230                 235                 


<210>  1015
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 WT  (vCD8) CD28_41BB

<400>  1015

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Ala 
        115                 120                 125             


Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
    130                 135                 140                 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
145                 150                 155                 160 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Trp 
                165                 170                 175     


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
            180                 185                 190         


Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu 
        195                 200                 205             


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
    210                 215                 220                 


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
225                 230                 235                 240 


Cys Glu Leu 
            


<210>  1016
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 WT  (vCD8) CD28_ICOS/41BB

<400>  1016

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Ala 
        115                 120                 125             


Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
    130                 135                 140                 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
145                 150                 155                 160 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Trp 
                165                 170                 175     


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
            180                 185                 190         


Thr Val Ala Phe Ile Ile Phe Trp Val Cys Trp Leu Thr Lys Lys Lys 
        195                 200                 205             


Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr Met Phe Met Arg 
    210                 215                 220                 


Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp Val Thr Leu Lys 
225                 230                 235                 240 


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
                245                 250                 255     


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
            260                 265                 270         


Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        275                 280     


<210>  1017
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 WT  (vCD8) CD28_41BB/ICOS

<400>  1017

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Ala 
        115                 120                 125             


Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
    130                 135                 140                 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
145                 150                 155                 160 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Trp 
                165                 170                 175     


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
            180                 185                 190         


Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu 
        195                 200                 205             


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
    210                 215                 220                 


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
225                 230                 235                 240 


Cys Glu Leu Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His 
                245                 250                 255     


Asp Pro Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys 
            260                 265                 270         


Lys Ser Arg Leu Thr Asp Val Thr Leu 
        275                 280     


<210>  1018
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v201  (vCD8) CD28_ICOS

<400>  1018

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe His Val Ile Trp His Arg Glu Ser Pro Ser 
        35                  40                  45              


Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Ala Lys Pro Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Ser Asp Trp Val Leu Val Val Val 
                165                 170                 175     


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
            180                 185                 190         


Ile Phe Trp Val Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val 
        195                 200                 205             


His Asp Pro Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala 
    210                 215                 220                 


Lys Lys Ser Arg Leu Thr Asp Val Thr Leu 
225                 230                 


<210>  1019
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v201  (vCD8) CD28_41BB

<400>  1019

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe His Val Ile Trp His Arg Glu Ser Pro Ser 
        35                  40                  45              


Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Ala Lys Pro Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Ser Asp Trp Val Leu Val Val Val 
                165                 170                 175     


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
            180                 185                 190         


Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        195                 200                 205             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    210                 215                 220                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
225                 230                 235             


<210>  1020
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v201  (vCD8) CD28_ICOS/41BB

<400>  1020

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe His Val Ile Trp His Arg Glu Ser Pro Ser 
        35                  40                  45              


Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Ala Lys Pro Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Ser Asp Trp Val Leu Val Val Val 
                165                 170                 175     


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
            180                 185                 190         


Ile Phe Trp Val Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val 
        195                 200                 205             


His Asp Pro Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala 
    210                 215                 220                 


Lys Lys Ser Arg Leu Thr Asp Val Thr Leu Lys Arg Gly Arg Lys Lys 
225                 230                 235                 240 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
                245                 250                 255     


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
            260                 265                 270         


Gly Cys Glu Leu 
        275     


<210>  1021
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v201  (vCD8) CD28_41BB/ICOS

<400>  1021

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe His Val Ile Trp His Arg Glu Ser Pro Ser 
        35                  40                  45              


Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Ala Lys Pro Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Ser Asp Trp Val Leu Val Val Val 
                165                 170                 175     


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
            180                 185                 190         


Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        195                 200                 205             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    210                 215                 220                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Cys Trp 
225                 230                 235                 240 


Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu 
                245                 250                 255     


Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr 
            260                 265                 270         


Asp Val Thr Leu 
        275     


<210>  1022
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v196  (vCD8) CD28_CD28

<400>  1022

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Asp Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg Ala Lys Pro Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Ser Asp Trp Val Leu Val Val Val 
                165                 170                 175     


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
            180                 185                 190         


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
        195                 200                 205             


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
    210                 215                 220                 


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
225                 230                 235         


<210>  1023
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v196  (vCD8) CD28_CD28/41BB

<400>  1023

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Asp Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg Ala Lys Pro Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Ser Asp Trp Val Leu Val Val Val 
                165                 170                 175     


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
            180                 185                 190         


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
        195                 200                 205             


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
    210                 215                 220                 


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly 
225                 230                 235                 240 


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
                245                 250                 255     


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
            260                 265                 270         


Glu Glu Gly Gly Cys Glu Leu 
        275                 


<210>  1024
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v196  (vCD8) CD28_CD28/ICOS

<400>  1024

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Asp Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg Ala Lys Pro Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Ser Asp Trp Val Leu Val Val Val 
                165                 170                 175     


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
            180                 185                 190         


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
        195                 200                 205             


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
    210                 215                 220                 


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Cys Trp Leu 
225                 230                 235                 240 


Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr 
                245                 250                 255     


Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp 
            260                 265                 270         


Val Thr Leu 
        275 


<210>  1025
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v196  (vCD8) CD28_CD28/ICOS/41BB

<400>  1025

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Asp Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg Ala Lys Pro Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Ser Asp Trp Val Leu Val Val Val 
                165                 170                 175     


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
            180                 185                 190         


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
        195                 200                 205             


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
    210                 215                 220                 


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Cys Trp Leu 
225                 230                 235                 240 


Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr 
                245                 250                 255     


Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp 
            260                 265                 270         


Val Thr Leu Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        275                 280                 285             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    290                 295                 300                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
305                 310                 315         


<210>  1026
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v196  (vCD8) CD28_ICOS

<400>  1026

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Asp Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg Ala Lys Pro Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Ser Asp Trp Val Leu Val Val Val 
                165                 170                 175     


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
            180                 185                 190         


Ile Phe Trp Val Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val 
        195                 200                 205             


His Asp Pro Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala 
    210                 215                 220                 


Lys Lys Ser Arg Leu Thr Asp Val Thr Leu 
225                 230                 


<210>  1027
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v196  (vCD8) CD28_41BB

<400>  1027

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Asp Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg Ala Lys Pro Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Ser Asp Trp Val Leu Val Val Val 
                165                 170                 175     


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
            180                 185                 190         


Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        195                 200                 205             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    210                 215                 220                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
225                 230                 235             


<210>  1028
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v196  (vCD8) CD28_ICOS/41BB

<400>  1028

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Asp Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg Ala Lys Pro Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Ser Asp Trp Val Leu Val Val Val 
                165                 170                 175     


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
            180                 185                 190         


Ile Phe Trp Val Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val 
        195                 200                 205             


His Asp Pro Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala 
    210                 215                 220                 


Lys Lys Ser Arg Leu Thr Asp Val Thr Leu Lys Arg Gly Arg Lys Lys 
225                 230                 235                 240 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
                245                 250                 255     


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
            260                 265                 270         


Gly Cys Glu Leu 
        275     


<210>  1029
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v196  (vCD8) CD28_41BB/ICOS

<400>  1029

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Asp Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg Ala Lys Pro Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Ser Asp Trp Val Leu Val Val Val 
                165                 170                 175     


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
            180                 185                 190         


Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        195                 200                 205             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    210                 215                 220                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Cys Trp 
225                 230                 235                 240 


Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu 
                245                 250                 255     


Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr 
            260                 265                 270         


Asp Val Thr Leu 
        275     


<210>  1030
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v196  (vCD8) 41BB_41BB

<400>  1030

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Asp Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg Ala Lys Pro Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Ser Asp Ile Ile Ser Phe Phe Leu 
                165                 170                 175     


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
            180                 185                 190         


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
        195                 200                 205             


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
    210                 215                 220                 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
225                 230                 235                 


<210>  1031
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v196  (vCD8) ICOS_ICOS

<400>  1031

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Asp Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg Ala Lys Pro Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Ser Asp Phe Trp Leu Pro Ile Gly 
                165                 170                 175     


Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu Ile Cys 
            180                 185                 190         


Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly 
        195                 200                 205             


Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu 
    210                 215                 220                 


Thr Asp Val Thr Leu 
225                 


<210>  1032
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v196  (vCD8) CD28_RSKS

<400>  1032

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Asp Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg Ala Lys Pro Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Ser Asp Trp Val Leu Val Val Val 
                165                 170                 175     


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
            180                 185                 190         


Ile Phe Trp Val Arg Ser Lys Ser 
        195                 200 


<210>  1033
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v196  (CD8) CD28_CD28

<400>  1033

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Asp Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg Ala Lys Pro Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Trp Val Leu Val Val Val 
                165                 170                 175     


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
            180                 185                 190         


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
        195                 200                 205             


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
    210                 215                 220                 


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
225                 230                 235         


<210>  1034
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v196  (CD8) CD28_CD28/41BB

<400>  1034

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Asp Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg Ala Lys Pro Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Trp Val Leu Val Val Val 
                165                 170                 175     


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
            180                 185                 190         


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
        195                 200                 205             


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
    210                 215                 220                 


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly 
225                 230                 235                 240 


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
                245                 250                 255     


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
            260                 265                 270         


Glu Glu Gly Gly Cys Glu Leu 
        275                 


<210>  1035
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v196  (CD8) CD28_CD28/ICOS

<400>  1035

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Asp Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg Ala Lys Pro Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Trp Val Leu Val Val Val 
                165                 170                 175     


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
            180                 185                 190         


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
        195                 200                 205             


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
    210                 215                 220                 


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Cys Trp Leu 
225                 230                 235                 240 


Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr 
                245                 250                 255     


Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp 
            260                 265                 270         


Val Thr Leu 
        275 


<210>  1036
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v196  (CD8) CD28_CD28/ICOS/41BB

<400>  1036

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser 
        35                  40                  45              


Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro 
    50                  55                  60                  


Gly Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Tyr His Met Ser Val Asp Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Leu Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser 
            100                 105                 110         


Leu Arg Val Glu Leu Arg Val Thr Glu Arg Ala Lys Pro Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Trp Val Leu Val Val Val 
                165                 170                 175     


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
            180                 185                 190         


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
        195                 200                 205             


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
    210                 215                 220                 


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Cys Trp Leu 
225                 230                 235                 240 


Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr 
                245                 250                 255     


Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp 
            260                 265                 270         


Val Thr Leu Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        275                 280                 285             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    290                 295                 300                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
305                 310                 315         


<210>  1037
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 v201  (vCD8) CD28_CD28

<400>  1037
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttccacgtg      120

atctggcacc gcgaaagccc cagcggccag acggacacac tggccgcctt ccccgaggac      180

cgcagccagc ccggccagga ctgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

ttccacatga gcgtggtcag ggcccggcgc aatgacagcg gcacctacgt gtgtggggtg      300

atctccctgg cccccaagat ccagatcaaa gagagcctgc gggcagagct cagggtgaca      360

gagagagcca agcctaccac cacccctgcc cctagacctc caacacccgc cccaacaatc      420

gccagccagc ctctgtctct gaggcccgag gcttgtagac cagctgctgg cggagccgta      480

cacaccagag gactggattt cgccagcgac tgggtgctgg tagtggtggg gggggtcctg      540

gcctgctatt ctctgctcgt cacggtcgcc tttatcattt tttgggtgcg gagtaagaga      600

agccgcctcc tccacagcga ctacatgaat atgaccccgc gcaggccggg gcctacaaga      660

aagcattacc agccgtatgc tccaccacga gattttgctg cttacaggag c               711


<210>  1038
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 v201  (vCD8) 41BB_41BB

<400>  1038
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttccacgtg      120

atctggcacc gcgaaagccc cagcggccag acggacacac tggccgcctt ccccgaggac      180

cgcagccagc ccggccagga ctgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

ttccacatga gcgtggtcag ggcccggcgc aatgacagcg gcacctacgt gtgtggggtg      300

atctccctgg cccccaagat ccagatcaaa gagagcctgc gggcagagct cagggtgaca      360

gagagagcca agcctaccac cacccctgcc cctagacctc caacacccgc cccaacaatc      420

gccagccagc ctctgtctct gaggcccgag gcttgtagac cagctgctgg cggagccgta      480

cacaccagag gactggattt cgccagcgac atcatatcat tcttcttggc tctgacctct      540

acagctctgc tgttcctttt gttttttctc acactccgct tttctgtagt taaacggggt      600

agaaagaagc tcctctacat attcaaacag ccgtttatga gacccgttca gactacccaa      660

gaagaggatg ggtgtagttg ccgctttccc gaggaggaag agggaggatg tgaactg         717


<210>  1039
<211>  693
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 v201  (vCD8) ICOS_ICOS

<400>  1039
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttccacgtg      120

atctggcacc gcgaaagccc cagcggccag acggacacac tggccgcctt ccccgaggac      180

cgcagccagc ccggccagga ctgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

ttccacatga gcgtggtcag ggcccggcgc aatgacagcg gcacctacgt gtgtggggtg      300

atctccctgg cccccaagat ccagatcaaa gagagcctgc gggcagagct cagggtgaca      360

gagagagcca agcctaccac cacccctgcc cctagacctc caacacccgc cccaacaatc      420

gccagccagc ctctgtctct gaggcccgag gcttgtagac cagctgctgg cggagccgtg      480

cacaccagag gactggattt cgccagcgac ttgaaattct ggctccccat cggatgcgct      540

gcgttcgtcg ttgtctgcat tcttggatgc atccttattt gctggctgac caaaaagaaa      600

tactcatcta gcgttcacga cccgaacggc gaatacatgt tcatgcgagc ggtaaacacc      660

gcaaagaaat cacggttgac cgacgtaacc ctt                                   693


<210>  1040
<211>  837
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 v201  (vCD8) CD28_CD28/41BB

<400>  1040
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttccacgtg      120

atctggcacc gcgaaagccc cagcggccag acggacacac tggccgcctt ccccgaggac      180

cgcagccagc ccggccagga ctgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

ttccacatga gcgtggtcag ggcccggcgc aatgacagcg gcacctacgt gtgtggggtg      300

atctccctgg cccccaagat ccagatcaaa gagagcctgc gggcagagct cagggtgaca      360

gagagagcca agcctaccac cacccctgcc cctagacctc caacacccgc cccaacaatc      420

gccagccagc ctctgtctct gaggcccgag gcttgtagac cagctgctgg cggagccgta      480

cacaccagag gactggattt cgccagcgac tgggtgctgg tagtggtggg gggggtcctg      540

gcctgctatt ctctgctcgt cacggtcgcc tttatcattt tttgggtgcg gagtaagaga      600

agccgcctcc tccacagcga ctacatgaat atgaccccgc gcaggccggg gcctacaaga      660

aagcattacc agccgtatgc tccaccacga gattttgctg cttacaggag caaacggggt      720

agaaagaagc tcctctacat attcaaacag ccgtttatga gacccgttca gactacccaa      780

gaagaggatg ggtgtagttg ccgctttccc gaggaggaag agggaggatg tgaactg         837


<210>  1041
<211>  825
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 v201  (vCD8) CD28_CD28/ICOS

<400>  1041
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttccacgtg      120

atctggcacc gcgaaagccc cagcggccag acggacacac tggccgcctt ccccgaggac      180

cgcagccagc ccggccagga ctgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

ttccacatga gcgtggtcag ggcccggcgc aatgacagcg gcacctacgt gtgtggggtg      300

atctccctgg cccccaagat ccagatcaaa gagagcctgc gggcagagct cagggtgaca      360

gagagagcca agcctaccac cacccctgcc cctagacctc caacacccgc cccaacaatc      420

gccagccagc ctctgtctct gaggcccgag gcttgtagac cagctgctgg cggagccgta      480

cacaccagag gactggattt cgccagcgac tgggtactgg tagtggtggg gggggtcctg      540

gcctgctatt ctctgctcgt cacggtcgcc tttatcattt tttgggtgcg gagtaagaga      600

agccgcctcc tccacagcga ctacatgaat atgaccccgc gcaggccggg gcctacaaga      660

aagcattacc agccgtatgc tccaccacga gattttgctg cttacaggag ctgctggctg      720

accaaaaaga aatactcatc tagcgttcac gacccgaacg gcgaatacat gttcatgcga      780

gcggtaaaca ccgcaaagaa atcacggttg accgacgtaa ccctt                      825


<210>  1042
<211>  840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 v201  (vCD8) 41BB_41BB/CD28

<400>  1042
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttccacgtg      120

atctggcacc gcgaaagccc cagcggccag acggacacac tggccgcctt ccccgaggac      180

cgcagccagc ccggccagga ctgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

ttccacatga gcgtggtcag ggcccggcgc aatgacagcg gcacctacgt gtgtggggtg      300

atctccctgg cccccaagat ccagatcaaa gagagcctgc gggcagagct cagggtgaca      360

gagagagcca agcctaccac cacccctgcc cctagacctc caacacccgc cccaacaatc      420

gccagccagc ctctgtctct gaggcccgag gcttgtagac cagctgctgg cggagccgta      480

cacaccagag gactggattt cgccagcgac atcatatcat tcttcttggc tctgacctct      540

acagctctgc tgttcctttt gttttttctc acactccgct tttctgtagt taaacggggt      600

agaaagaagc tcctctacat attcaaacag ccgtttatga gacccgttca gactacccaa      660

gaagaggatg ggtgtagttg ccgctttccc gaggaggaag agggaggatg tgaactgcgg      720

agtaagagaa gccgcctcct ccacagcgac tacatgaata tgaccccgcg caggccgggg      780

cctacaagaa agcattacca gccgtatgct ccaccacgag attttgctgc ttacaggagc      840


<210>  1043
<211>  831
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 v201  (vCD8) 41BB_41BB/ICOS

<400>  1043
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttccacgtg      120

atctggcacc gcgaaagccc cagcggccag acggacacac tggccgcctt ccccgaggac      180

cgcagccagc ccggccagga ctgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

ttccacatga gcgtggtcag ggcccggcgc aatgacagcg gcacctacgt gtgtggggtg      300

atctccctgg cccccaagat ccagatcaaa gagagcctgc gggcagagct cagggtgaca      360

gagagagcca agcctaccac cacccctgcc cctagacctc caacacccgc cccaacaatc      420

gccagccagc ctctgtctct gaggcccgag gcttgtagac cagctgctgg cggagccgtg      480

cacaccagag gactggattt cgcctgcgac atcatatcat tcttcttggc tctgacctct      540

acagctctgc tgttcctttt gttttttctc acactccgct tttctgtagt taaacggggt      600

agaaagaagc tcctctacat attcaaacag ccgtttatga gacccgttca gactacccaa      660

gaagaggatg ggtgtagttg ccgctttccc gaggaggaag agggaggatg tgaactgtgc      720

tggctgacca aaaagaaata ctcatctagc gttcacgacc cgaacggcga atacatgttc      780

atgcgagcgg taaacaccgc aaagaaatca cggttgaccg acgtaaccct t               831


<210>  1044
<211>  810
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 v201  (vCD8) ICOS_ICOS/CD28

<400>  1044
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttccacgtg      120

atctggcacc gcgaaagccc cagcggccag acggacacac tggccgcctt ccccgaggac      180

cgcagccagc ccggccagga ctgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

ttccacatga gcgtggtcag ggcccggcgc aatgacagcg gcacctacgt gtgtggggtg      300

atctccctgg cccccaagat ccagatcaaa gagagcctgc gggcagagct cagggtgaca      360

gagagagcca agcctaccac cacccctgcc cctagacctc caacacccgc cccaacaatc      420

gccagccagc ctctgtctct gaggcccgag gcttgtagac cagctgctgg cggagccgta      480

cacaccagag gactggattt cgccagcgac ttctggctcc ccatcggatg cgctgcgttc      540

gtcgttgtct gcattcttgg atgcatcctt atttgctggc tgaccaaaaa gaaatactca      600

tctagcgttc acgacccgaa cggcgaatac atgttcatgc gagcggtaaa caccgcaaag      660

aaatcacggt tgaccgacgt aacccttcgg agtaagagaa gccgcctcct ccacagcgac      720

tacatgaata tgaccccgcg caggccgggg cctacaagaa agcattacca gccgtatgct      780

ccaccacgag attttgctgc ttacaggagc                                       810


<210>  1045
<211>  813
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 v201  (vCD8) ICOS_ICOS/41BB

<400>  1045
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttccacgtg      120

atctggcacc gcgaaagccc cagcggccag acggacacac tggccgcctt ccccgaggac      180

cgcagccagc ccggccagga ctgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

ttccacatga gcgtggtcag ggcccggcgc aatgacagcg gcacctacgt gtgtggggtg      300

atctccctgg cccccaagat ccagatcaaa gagagcctgc gggcagagct cagggtgaca      360

gagagagcca agcctaccac cacccctgcc cctagacctc caacacccgc cccaacaatc      420

gccagccagc ctctgtctct gaggcccgag gcttgtagac cagctgctgg cggagccgta      480

cacaccagag gactggattt cgccagcgac ttctggctcc ccatcggatg cgctgcgttc      540

gtcgttgtct gcattcttgg atgcatcctt atttgctggc tgaccaaaaa gaaatactca      600

tctagcgttc acgacccgaa cggcgaatac atgttcatgc gagcggtaaa caccgcaaag      660

aaatcacggt tgaccgacgt aacccttaaa cggggtagaa agaagctcct ctacatattc      720

aaacagccgt ttatgagacc cgttcagact acccaagaag aggatgggtg tagttgccgc      780

tttcccgagg aggaagaggg aggatgtgaa ctg                                   813


<210>  1046
<211>  951
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 v201  (vCD8)CD28_CD28/ICOS/41BB

<400>  1046
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttccacgtg      120

atctggcacc gcgaaagccc cagcggccag acggacacac tggccgcctt ccccgaggac      180

cgcagccagc ccggccagga ctgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

ttccacatga gcgtggtcag ggcccggcgc aatgacagcg gcacctacgt gtgtggggtg      300

atctccctgg cccccaagat ccagatcaaa gagagcctgc gggcagagct cagggtgaca      360

gagagagcca agcctaccac cacccctgcc cctagacctc caacacccgc cccaacaatc      420

gccagccagc ctctgtctct gaggcccgag gcttgtagac cagctgctgg cggagccgta      480

cacaccagag gactggattt cgccagcgac tgggtgctgg tagtggtggg gggggtcctg      540

gcctgctatt ctctgctcgt cacggtcgcc tttatcattt tttgggtgcg gagtaagaga      600

agccgcctcc tccacagcga ctacatgaat atgaccccgc gcaggccggg gcctacaaga      660

aagcattacc agccgtatgc tccaccacga gattttgctg cttacaggag ctgctggctg      720

accaaaaaga aatactcatc tagcgttcac gacccgaacg gcgaatacat gttcatgcga      780

gcggtaaaca ccgcaaagaa atcacggttg accgacgtaa cccttaaacg gggtagaaag      840

aagctcctct acatattcaa acagccgttt atgagacccg ttcagactac ccaagaagag      900

gatgggtgta gttgccgctt tcccgaggag gaagagggag gatgtgaact g               951


<210>  1047
<211>  600
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 v201  (vCD8)CD28_RSKS

<400>  1047
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttccacgtg      120

atctggcacc gcgaaagccc cagcggccag acggacacac tggccgcctt ccccgaggac      180

cgcagccagc ccggccagga ctgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

ttccacatga gcgtggtcag ggcccggcgc aatgacagcg gcacctacgt gtgtggggtg      300

atctccctgg cccccaagat ccagatcaaa gagagcctgc gggcagagct cagggtgaca      360

gagagagcca agcctaccac cacccctgcc cctagacctc caacacccgc cccaacaatc      420

gccagccagc ctctgtctct gaggcccgag gcttgtagac cagctgctgg cggagccgta      480

cacaccagag gactggattt cgccagcgac tgggtgctgg tagtggtggg gggggtcctg      540

gcctgctatt ctctgctcgt cacggtcgcc tttatcattt tttgggtgcg gagtaagtcc      600


<210>  1048
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 WT  (CD8) CD28_CD28

<400>  1048
ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc       60

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      120

gagagcttcg tgctaaactg gtatcgcatg agccccagca accagacgga caagctggcc      180

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      240

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      300

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      360

gagctcaggg tgacagagag agccaagcct accaccaccc ctgcccctag acctccaaca      420

cccgccccaa caatcgccag ccagcctctg tctctgaggc ccgaggcttg tagaccagct      480

gctggcggag ccgtacacac cagaggactg gatttcgcct gcgactgggt gctggtagtg      540

gtgggggggg tcctggcctg ctattctctg ctcgtcacgg tcgcctttat cattttttgg      600

gtgcggagta agagaagccg cctcctccac agcgactaca tgaatatgac cccgcgcagg      660

ccggggccta caagaaagca ttaccagccg tatgctccac cacgagattt tgctgcttac      720

aggagc                                                                 726


<210>  1049
<211>  852
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 WT  (CD8) CD28_CD28/41BB

<400>  1049
ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc       60

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      120

gagagcttcg tgctaaactg gtatcgcatg agccccagca accagacgga caagctggcc      180

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      240

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      300

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      360

gagctcaggg tgacagagag agccaagcct accaccaccc ctgcccctag acctccaaca      420

cccgccccaa caatcgccag ccagcctctg tctctgaggc ccgaggcttg tagaccagct      480

gctggcggag ccgtacacac cagaggactg gatttcgcct gcgactgggt gctggtagtg      540

gtgggggggg tcctggcctg ctattctctg ctcgtcacgg tcgcctttat cattttttgg      600

gtgcggagta agagaagccg cctcctccac agcgactaca tgaatatgac cccgcgcagg      660

ccggggccta caagaaagca ttaccagccg tatgctccac cacgagattt tgctgcttac      720

aggagcaaac ggggtagaaa gaagctcctc tacatattca aacagccgtt tatgagaccc      780

gttcagacta cccaagaaga ggatgggtgt agttgccgct ttcccgagga ggaagaggga      840

ggatgtgaac tg                                                          852


<210>  1050
<211>  840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 WT  (CD8) CD28_CD28/ICOS

<400>  1050
ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc       60

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      120

gagagcttcg tgctaaactg gtatcgcatg agccccagca accagacgga caagctggcc      180

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      240

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      300

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      360

gagctcaggg tgacagagag agccaagcct accaccaccc ctgcccctag acctccaaca      420

cccgccccaa caatcgccag ccagcctctg tctctgaggc ccgaggcttg tagaccagct      480

gctggcggag ccgtacacac cagaggactg gatttcgcct gcgactgggt gctggtagtg      540

gtgggggggg tcctggcctg ctattctctg ctcgtcacgg tcgcctttat cattttttgg      600

gtgcggagta agagaagccg cctcctccac agcgactaca tgaatatgac cccgcgcagg      660

ccggggccta caagaaagca ttaccagccg tatgctccac cacgagattt tgctgcttac      720

aggagctgct ggctgaccaa aaagaaatac tcatctagcg ttcacgaccc gaacggcgaa      780

tacatgttca tgcgagcggt aaacaccgca aagaaatcac ggttgaccga cgtaaccctt      840


<210>  1051
<211>  966
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 WT  (CD8) CD28_CD28/ICOS/41BB

<400>  1051
ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc       60

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      120

gagagcttcg tgctaaactg gtatcgcatg agccccagca accagacgga caagctggcc      180

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      240

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      300

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      360

gagctcaggg tgacagagag agccaagcct accaccaccc ctgcccctag acctccaaca      420

cccgccccaa caatcgccag ccagcctctg tctctgaggc ccgaggcttg tagaccagct      480

gctggcggag ccgtacacac cagaggactg gatttcgcct gcgactgggt gctggtagtg      540

gtgggggggg tcctggcctg ctattctctg ctcgtcacgg tcgcctttat cattttttgg      600

gtgcggagta agagaagccg cctcctccac agcgactaca tgaatatgac cccgcgcagg      660

ccggggccta caagaaagca ttaccagccg tatgctccac cacgagattt tgctgcttac      720

aggagctgct ggctgaccaa aaagaaatac tcatctagcg ttcacgaccc gaacggcgaa      780

tacatgttca tgcgagcggt aaacaccgca aagaaatcac ggttgaccga cgtaaccctt      840

aaacggggta gaaagaagct cctctacata ttcaaacagc cgtttatgag acccgttcag      900

actacccaag aagaggatgg gtgtagttgc cgctttcccg aggaggaaga gggaggatgt      960

gaactg                                                                 966


<210>  1052
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 WT  (CD8) CD28_RSKS

<400>  1052
ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc       60

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      120

gagagcttcg tgctaaactg gtatcgcatg agccccagca accagacgga caagctggcc      180

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      240

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      300

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      360

gagctcaggg tgacagagag agccaagcct accaccaccc ctgcccctag acctccaaca      420

cccgccccaa caatcgccag ccagcctctg tctctgaggc ccgaggcttg tagaccagct      480

gctggcggag ccgtacacac cagaggactg gatttcgcct gcgactgggt gctggtagtg      540

gtgggggggg tcctggcctg ctattctctg ctcgtcacgg tcgcctttat cattttttgg      600

gtgcggagta agtcc                                                       615


<210>  1053
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 WT  (vCD8) CD28_CD28

<400>  1053
ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc       60

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      120

gagagcttcg tgctaaactg gtatcgcatg agccccagca accagacgga caagctggcc      180

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      240

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      300

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      360

gagctcaggg tgacagagag agccaagcct accaccaccc ctgcccctag acctccaaca      420

cccgccccaa caatcgccag ccagcctctg tctctgaggc ccgaggcttg tagaccagct      480

gctggcggag ccgtacacac cagaggactg gatttcgcca gcgactgggt gctggtagtg      540

gtgggggggg tcctggcctg ctattctctg ctcgtcacgg tcgcctttat cattttttgg      600

gtgcggagta agagaagccg cctcctccac agcgactaca tgaatatgac cccgcgcagg      660

ccggggccta caagaaagca ttaccagccg tatgctccac cacgagattt tgctgcttac      720

aggagc                                                                 726


<210>  1054
<211>  852
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 WT  (vCD8) CD28_CD28/41BB

<400>  1054
ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc       60

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      120

gagagcttcg tgctaaactg gtatcgcatg agccccagca accagacgga caagctggcc      180

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      240

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      300

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      360

gagctcaggg tgacagagag agccaagcct accaccaccc ctgcccctag acctccaaca      420

cccgccccaa caatcgccag ccagcctctg tctctgaggc ccgaggcttg tagaccagct      480

gctggcggag ccgtacacac cagaggactg gatttcgcca gcgactgggt gctggtagtg      540

gtgggggggg tcctggcctg ctattctctg ctcgtcacgg tcgcctttat cattttttgg      600

gtgcggagta agagaagccg cctcctccac agcgactaca tgaatatgac cccgcgcagg      660

ccggggccta caagaaagca ttaccagccg tatgctccac cacgagattt tgctgcttac      720

aggagcaaac ggggtagaaa gaagctcctc tacatattca aacagccgtt tatgagaccc      780

gttcagacta cccaagaaga ggatgggtgt agttgccgct ttcccgagga ggaagaggga      840

ggatgtgaac tg                                                          852


<210>  1055
<211>  840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 WT  (vCD8) CD28_CD28/ICOS

<400>  1055
ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc       60

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      120

gagagcttcg tgctaaactg gtatcgcatg agccccagca accagacgga caagctggcc      180

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      240

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      300

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      360

gagctcaggg tgacagagag agccaagcct accaccaccc ctgcccctag acctccaaca      420

cccgccccaa caatcgccag ccagcctctg tctctgaggc ccgaggcttg tagaccagct      480

gctggcggag ccgtacacac cagaggactg gatttcgcca gcgactgggt gctggtagtg      540

gtgggggggg tcctggcctg ctattctctg ctcgtcacgg tcgcctttat cattttttgg      600

gtgcggagta agagaagccg cctcctccac agcgactaca tgaatatgac cccgcgcagg      660

ccggggccta caagaaagca ttaccagccg tatgctccac cacgagattt tgctgcttac      720

aggagctgct ggctgaccaa aaagaaatac tcatctagcg ttcacgaccc gaacggcgaa      780

tacatgttca tgcgagcggt aaacaccgca aagaaatcac ggttgaccga cgtaaccctt      840


<210>  1056
<211>  966
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 WT  (vCD8) CD28_CD28/ICOS/41BB

<400>  1056
ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc       60

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      120

gagagcttcg tgctaaactg gtatcgcatg agccccagca accagacgga caagctggcc      180

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      240

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      300

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      360

gagctcaggg tgacagagag agccaagcct accaccaccc ctgcccctag acctccaaca      420

cccgccccaa caatcgccag ccagcctctg tctctgaggc ccgaggcttg tagaccagct      480

gctggcggag ccgtacacac cagaggactg gatttcgcca gcgactgggt gctggtagtg      540

gtgggggggg tcctggcctg ctattctctg ctcgtcacgg tcgcctttat cattttttgg      600

gtgcggagta agagaagccg cctcctccac agcgactaca tgaatatgac cccgcgcagg      660

ccggggccta caagaaagca ttaccagccg tatgctccac cacgagattt tgctgcttac      720

aggagctgct ggctgaccaa aaagaaatac tcatctagcg ttcacgaccc gaacggcgaa      780

tacatgttca tgcgagcggt aaacaccgca aagaaatcac ggttgaccga cgtaaccctt      840

aaacggggta gaaagaagct cctctacata ttcaaacagc cgtttatgag acccgttcag      900

actacccaag aagaggatgg gtgtagttgc cgctttcccg aggaggaaga gggaggatgt      960

gaactg                                                                 966


<210>  1057
<211>  615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 WT  (vCD8) CD28_RSKS

<400>  1057
ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc       60

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      120

gagagcttcg tgctaaactg gtatcgcatg agccccagca accagacgga caagctggcc      180

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      240

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      300

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      360

gagctcaggg tgacagagag agccaagcct accaccaccc ctgcccctag acctccaaca      420

cccgccccaa caatcgccag ccagcctctg tctctgaggc ccgaggcttg tagaccagct      480

gctggcggag ccgtacacac cagaggactg gatttcgcca gcgactgggt gctggtagtg      540

gtgggggggg tcctggcctg ctattctctg ctcgtcacgg tcgcctttat cattttttgg      600

gtgcggagta agtcc                                                       615


<210>  1058
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 WT  (vCD8) CD28_ICOS

<400>  1058
ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc       60

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      120

gagagcttcg tgctaaactg gtatcgcatg agccccagca accagacgga caagctggcc      180

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      240

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      300

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      360

gagctcaggg tgacagagag agccaagcct accaccaccc ctgcccctag acctccaaca      420

cccgccccaa caatcgccag ccagcctctg tctctgaggc ccgaggcttg tagaccagct      480

gctggcggag ccgtacacac cagaggactg gatttcgcca gcgactgggt gctggtagtg      540

gtgggggggg tcctggcctg ctattctctg ctcgtcacgg tcgcctttat cattttttgg      600

gtgtgctggc tgaccaaaaa gaaatactca tctagcgttc acgacccgaa cggcgaatac      660

atgttcatgc gagcggtaaa caccgcaaag aaatcacggt tgaccgacgt aaccctt         717


<210>  1059
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 WT  (vCD8) CD28_41BB

<400>  1059
ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc       60

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      120

gagagcttcg tgctaaactg gtatcgcatg agccccagca accagacgga caagctggcc      180

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      240

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      300

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      360

gagctcaggg tgacagagag agccaagcct accaccaccc ctgcccctag acctccaaca      420

cccgccccaa caatcgccag ccagcctctg tctctgaggc ccgaggcttg tagaccagct      480

gctggcggag ccgtacacac cagaggactg gatttcgcca gcgactgggt gctggtagtg      540

gtgggggggg tcctggcctg ctattctctg ctcgtcacgg tcgcctttat cattttttgg      600

gtgaaacggg gtagaaagaa gctcctctac atattcaaac agccgtttat gagacccgtt      660

cagactaccc aagaagagga tgggtgtagt tgccgctttc ccgaggagga agagggagga      720

tgtgaactg                                                              729


<210>  1060
<211>  843
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 WT  (vCD8) CD28_ICOS/41BB

<400>  1060
ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc       60

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      120

gagagcttcg tgctaaactg gtatcgcatg agccccagca accagacgga caagctggcc      180

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      240

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      300

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      360

gagctcaggg tgacagagag agccaagcct accaccaccc ctgcccctag acctccaaca      420

cccgccccaa caatcgccag ccagcctctg tctctgaggc ccgaggcttg tagaccagct      480

gctggcggag ccgtacacac cagaggactg gatttcgcca gcgactgggt gctggtagtg      540

gtgggggggg tcctggcctg ctattctctg ctcgtcacgg tcgcctttat cattttttgg      600

gtgtgctggc tgaccaaaaa gaaatactca tctagcgttc acgacccgaa cggcgaatac      660

atgttcatgc gagcggtaaa caccgcaaag aaatcacggt tgaccgacgt aacccttaaa      720

cggggtagaa agaagctcct ctacatattc aaacagccgt ttatgagacc cgttcagact      780

acccaagaag aggatgggtg tagttgccgc tttcccgagg aggaagaggg aggatgtgaa      840

ctg                                                                    843


<210>  1061
<211>  843
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 WT  (vCD8) CD28_41BB/ICOS

<400>  1061
ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc       60

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      120

gagagcttcg tgctaaactg gtatcgcatg agccccagca accagacgga caagctggcc      180

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      240

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      300

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      360

gagctcaggg tgacagagag agccaagcct accaccaccc ctgcccctag acctccaaca      420

cccgccccaa caatcgccag ccagcctctg tctctgaggc ccgaggcttg tagaccagct      480

gctggcggag ccgtacacac cagaggactg gatttcgcca gcgactgggt gctggtagtg      540

gtgggggggg tcctggcctg ctattctctg ctcgtcacgg tcgcctttat cattttttgg      600

gtgaaacggg gtagaaagaa gctcctctac atattcaaac agccgtttat gagacccgtt      660

cagactaccc aagaagagga tgggtgtagt tgccgctttc ccgaggagga agagggagga      720

tgtgaactgt gctggctgac caaaaagaaa tactcatcta gcgttcacga cccgaacggc      780

gaatacatgt tcatgcgagc ggtaaacacc gcaaagaaat cacggttgac cgacgtaacc      840

ctt                                                                    843


<210>  1062
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 v201  (vCD8) CD28_ICOS

<400>  1062
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttccacgtg      120

atctggcacc gcgaaagccc cagcggccag acggacacac tggccgcctt ccccgaggac      180

cgcagccagc ccggccagga ctgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

ttccacatga gcgtggtcag ggcccggcgc aatgacagcg gcacctacgt gtgtggggtg      300

atctccctgg cccccaagat ccagatcaaa gagagcctgc gggcagagct cagggtgaca      360

gagagagcca agcctaccac cacccctgcc cctagacctc caacacccgc cccaacaatc      420

gccagccagc ctctgtctct gaggcccgag gcttgtagac cagctgctgg cggagccgta      480

cacaccagag gactggattt cgccagcgac tgggtactgg tagtggtggg gggggtcctg      540

gcctgctatt ctctgctcgt cacggtcgcc tttatcattt tttgggtgtg ctggctgacc      600

aaaaagaaat actcatctag cgttcacgac ccgaacggcg aatacatgtt catgcgagcg      660

gtaaacaccg caaagaaatc acggttgacc gacgtaaccc tt                         702


<210>  1063
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 v201  (vCD8) CD28_41BB

<400>  1063
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttccacgtg      120

atctggcacc gcgaaagccc cagcggccag acggacacac tggccgcctt ccccgaggac      180

cgcagccagc ccggccagga ctgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

ttccacatga gcgtggtcag ggcccggcgc aatgacagcg gcacctacgt gtgtggggtg      300

atctccctgg cccccaagat ccagatcaaa gagagcctgc gggcagagct cagggtgaca      360

gagagagcca agcctaccac cacccctgcc cctagacctc caacacccgc cccaacaatc      420

gccagccagc ctctgtctct gaggcccgag gcttgtagac cagctgctgg cggagccgta      480

cacaccagag gactggattt cgccagcgac tgggtgctgg tagtggtggg gggggtcctg      540

gcctgctatt ctctgctcgt cacggtcgcc tttatcattt tttgggtgaa acggggtaga      600

aagaagctcc tctacatatt caaacagccg tttatgagac ccgttcagac tacccaagaa      660

gaggatgggt gtagttgccg ctttcccgag gaggaagagg gaggatgtga actg            714


<210>  1064
<211>  828
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 v201  (vCD8) CD28_ICOS/41BB

<400>  1064
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttccacgtg      120

atctggcacc gcgaaagccc cagcggccag acggacacac tggccgcctt ccccgaggac      180

cgcagccagc ccggccagga ctgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

ttccacatga gcgtggtcag ggcccggcgc aatgacagcg gcacctacgt gtgtggggtg      300

atctccctgg cccccaagat ccagatcaaa gagagcctgc gggcagagct cagggtgaca      360

gagagagcca agcctaccac cacccctgcc cctagacctc caacacccgc cccaacaatc      420

gccagccagc ctctgtctct gaggcccgag gcttgtagac cagctgctgg cggagccgta      480

cacaccagag gactggattt cgccagcgac tgggtgctgg tagtggtggg gggggtcctg      540

gcctgctatt ctctgctcgt cacggtcgcc tttatcattt tttgggtgtg ctggctgacc      600

aaaaagaaat actcatctag cgttcacgac ccgaacggcg aatacatgtt catgcgagcg      660

gtaaacaccg caaagaaatc acggttgacc gacgtaaccc ttaaacgggg tagaaagaag      720

ctcctctaca tattcaaaca gccgtttatg agacccgttc agactaccca agaagaggat      780

gggtgtagtt gccgctttcc cgaggaggaa gagggaggat gtgaactg                   828


<210>  1065
<211>  828
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 v201  (vCD8) CD28_41BB/ICOS

<400>  1065
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttccacgtg      120

atctggcacc gcgaaagccc cagcggccag acggacacac tggccgcctt ccccgaggac      180

cgcagccagc ccggccagga ctgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

ttccacatga gcgtggtcag ggcccggcgc aatgacagcg gcacctacgt gtgtggggtg      300

atctccctgg cccccaagat ccagatcaaa gagagcctgc gggcagagct cagggtgaca      360

gagagagcca agcctaccac cacccctgcc cctagacctc caacacccgc cccaacaatc      420

gccagccagc ctctgtctct gaggcccgag gcttgtagac cagctgctgg cggagccgta      480

cacaccagag gactggattt cgccagcgac tgggtgctgg tagtggtggg gggggtcctg      540

gcctgctatt ctctgctcgt cacggtcgcc tttatcattt tttgggtgaa acggggtaga      600

aagaagctcc tctacatatt caaacagccg tttatgagac ccgttcagac tacccaagaa      660

gaggatgggt gtagttgccg ctttcccgag gaggaagagg gaggatgtga actgtgctgg      720

ctgaccaaaa agaaatactc atctagcgtt cacgacccga acggcgaata catgttcatg      780

cgagcggtaa acaccgcaaa gaaatcacgg ttgaccgacg taaccctt                   828


<210>  1066
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 v196  (vCD8) CD28_CD28

<400>  1066
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttcgtgcta      120

aactggtatc gcatgagccc cagcaaccag acggacaagc tggccgcctt ccccgaggac      180

cgcaaccagc ccggccagga ccgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

taccacatga gcgtggacag ggcccggcgc aatgacagcg gcacatacct ctgtggggcc      300

atcactctgg cccccaaggt gcagatcgat gagagcctgc gtgtagagct cagggtgaca      360

gagagagcca agcctaccac cacccctgcc cctagacctc caacacccgc cccaacaatc      420

gccagccagc ctctgtctct gaggcccgag gcttgtagac cagctgctgg cggagccgta      480

cacaccagag gactggattt cgccagcgac tgggtgctgg tagtggtggg gggggtcctg      540

gcctgctatt ctctgctcgt cacggtcgcc tttatcattt tttgggtgcg gagtaagaga      600

agccgcctcc tccacagcga ctacatgaat atgaccccgc gcaggccggg gcctacaaga      660

aagcattacc agccgtatgc tccaccacga gattttgctg cttacaggag c               711


<210>  1067
<211>  837
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 v196  (vCD8) CD28_CD28/41BB

<400>  1067
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttcgtgcta      120

aactggtatc gcatgagccc cagcaaccag acggacaagc tggccgcctt ccccgaggac      180

cgcaaccagc ccggccagga ccgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

taccacatga gcgtggacag ggcccggcgc aatgacagcg gcacatacct ctgtggggcc      300

atcactctgg cccccaaggt gcagatcgat gagagcctgc gtgtagagct cagggtgaca      360

gagagagcca agcctaccac cacccctgcc cctagacctc caacacccgc cccaacaatc      420

gccagccagc ctctgtctct gaggcccgag gcttgtagac cagctgctgg cggagccgta      480

cacaccagag gactggattt cgccagcgac tgggtgctgg tagtggtggg gggggtcctg      540

gcctgctatt ctctgctcgt cacggtcgcc tttatcattt tttgggtgcg gagtaagaga      600

agccgcctcc tccacagcga ctacatgaat atgaccccgc gcaggccggg gcctacaaga      660

aagcattacc agccgtatgc tccaccacga gattttgctg cttacaggag caaacggggt      720

agaaagaagc tcctctacat attcaaacag ccgtttatga gacccgttca gactacccaa      780

gaagaggatg ggtgtagttg ccgctttccc gaggaggaag agggaggatg tgaactg         837


<210>  1068
<211>  825
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 v196  (vCD8) CD28_CD28/ICOS

<400>  1068
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttcgtgcta      120

aactggtatc gcatgagccc cagcaaccag acggacaagc tggccgcctt ccccgaggac      180

cgcaaccagc ccggccagga ccgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

taccacatga gcgtggacag ggcccggcgc aatgacagcg gcacatacct ctgtggggcc      300

atcactctgg cccccaaggt gcagatcgat gagagcctgc gtgtagagct cagggtgaca      360

gagagagcca agcctaccac cacccctgcc cctagacctc caacacccgc cccaacaatc      420

gccagccagc ctctgtctct gaggcccgag gcttgtagac cagctgctgg cggagccgta      480

cacaccagag gactggattt cgccagcgac tgggtgctgg tagtggtggg gggggtcctg      540

gcctgctatt ctctgctcgt cacggtcgcc tttatcattt tttgggtgcg gagtaagaga      600

agccgcctcc tccacagcga ctacatgaat atgaccccgc gcaggccggg gcctacaaga      660

aagcattacc agccgtatgc tccaccacga gattttgctg cttacaggag ctgctggctg      720

accaaaaaga aatactcatc tagcgttcac gacccgaacg gcgaatacat gttcatgcga      780

gcggtaaaca ccgcaaagaa atcacggttg accgacgtaa ccctt                      825


<210>  1069
<211>  951
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 v196  (vCD8) CD28_CD28/ICOS/41BB

<400>  1069
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttcgtgcta      120

aactggtatc gcatgagccc cagcaaccag acggacaagc tggccgcctt ccccgaggac      180

cgcaaccagc ccggccagga ccgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

taccacatga gcgtggacag ggcccggcgc aatgacagcg gcacatacct ctgtggggcc      300

atcactctgg cccccaaggt gcagatcgat gagagcctgc gtgtagagct cagggtgaca      360

gagagagcca agcctaccac cacccctgcc cctagacctc caacacccgc cccaacaatc      420

gccagccagc ctctgtctct gaggcccgag gcttgtagac cagctgctgg cggagccgta      480

cacaccagag gactggattt cgccagcgac tgggtgctgg tagtggtggg gggggtcctg      540

gcctgctatt ctctgctcgt cacggtcgcc tttatcattt tttgggtgcg gagtaagaga      600

agccgcctcc tccacagcga ctacatgaat atgaccccgc gcaggccggg gcctacaaga      660

aagcattacc agccgtatgc tccaccacga gattttgctg cttacaggag ctgctggctg      720

accaaaaaga aatactcatc tagcgttcac gacccgaacg gcgaatacat gttcatgcga      780

gcggtaaaca ccgcaaagaa atcacggttg accgacgtaa cccttaaacg gggtagaaag      840

aagctcctct acatattcaa acagccgttt atgagacccg ttcagactac ccaagaagag      900

gatgggtgta gttgccgctt tcccgaggag gaagagggag gatgtgaact g               951


<210>  1070
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 v196  (vCD8) CD28_ICOS

<400>  1070
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttcgtgcta      120

aactggtatc gcatgagccc cagcaaccag acggacaagc tggccgcctt ccccgaggac      180

cgcaaccagc ccggccagga ccgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

taccacatga gcgtggacag ggcccggcgc aatgacagcg gcacatacct ctgtggggcc      300

atcactctgg cccccaaggt gcagatcgat gagagcctgc gtgtagagct cagggtgaca      360

gagagagcca agcctaccac cacccctgcc cctagacctc caacacccgc cccaacaatc      420

gccagccagc ctctgtctct gaggcccgag gcttgtagac cagctgctgg cggagccgta      480

cacaccagag gactggattt cgccagcgac tgggtgctgg tagtggtggg gggggtcctg      540

gcctgctatt ctctgctcgt cacggtcgcc tttatcattt tttgggtgtg ctggctgacc      600

aaaaagaaat actcatctag cgttcacgac ccgaacggcg aatacatgtt catgcgagcg      660

gtaaacaccg caaagaaatc acggttgacc gacgtaaccc tt                         702


<210>  1071
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 v196  (vCD8) CD28_41BB

<400>  1071
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttcgtgcta      120

aactggtatc gcatgagccc cagcaaccag acggacaagc tggccgcctt ccccgaggac      180

cgcaaccagc ccggccagga ccgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

taccacatga gcgtggacag ggcccggcgc aatgacagcg gcacatacct ctgtggggcc      300

atcactctgg cccccaaggt gcagatcgat gagagcctgc gtgtagagct cagggtgaca      360

gagagagcca agcctaccac cacccctgcc cctagacctc caacacccgc cccaacaatc      420

gccagccagc ctctgtctct gaggcccgag gcttgtagac cagctgctgg cggagccgta      480

cacaccagag gactggattt cgccagcgac tgggtgctgg tagtggtggg gggggtcctg      540

gcctgctatt ctctgctcgt cacggtcgcc tttatcattt tttgggtgaa acggggtaga      600

aagaagctcc tctacatatt caaacagccg tttatgagac ccgttcagac tacccaagaa      660

gaggatgggt gtagttgccg ctttcccgag gaggaagagg gaggatgtga actg            714


<210>  1072
<211>  828
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 v196  (vCD8) CD28_ICOS/41BB

<400>  1072
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttcgtgcta      120

aactggtatc gcatgagccc cagcaaccag acggacaagc tggccgcctt ccccgaggac      180

cgcaaccagc ccggccagga ccgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

taccacatga gcgtggacag ggcccggcgc aatgacagcg gcacatacct ctgtggggcc      300

atcactctgg cccccaaggt gcagatcgat gagagcctgc gtgtagagct cagggtgaca      360

gagagagcca agcctaccac cacccctgcc cctagacctc caacacccgc cccaacaatc      420

gccagccagc ctctgtctct gaggcccgag gcttgtagac cagctgctgg cggagccgta      480

cacaccagag gactggattt cgccagcgac tgggtgctgg tagtggtggg gggggtcctg      540

gcctgctatt ctctgctcgt cacggtcgcc tttatcattt tttgggtgtg ctggctgacc      600

aaaaagaaat actcatctag cgttcacgac ccgaacggcg aatacatgtt catgcgagcg      660

gtaaacaccg caaagaaatc acggttgacc gacgtaaccc ttaaacgggg tagaaagaag      720

ctcctctaca tattcaaaca gccgtttatg agacccgttc agactaccca agaagaggat      780

gggtgtagtt gccgctttcc cgaggaggaa gagggaggat gtgaactg                   828


<210>  1073
<211>  828
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 v196  (vCD8) CD28_41BB/ICOS

<400>  1073
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttcgtgcta      120

aactggtatc gcatgagccc cagcaaccag acggacaagc tggccgcctt ccccgaggac      180

cgcaaccagc ccggccagga ccgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

taccacatga gcgtggacag ggcccggcgc aatgacagcg gcacatacct ctgtggggcc      300

atcactctgg cccccaaggt gcagatcgat gagagcctgc gtgtagagct cagggtgaca      360

gagagagcca agcctaccac cacccctgcc cctagacctc caacacccgc cccaacaatc      420

gccagccagc ctctgtctct gaggcccgag gcttgtagac cagctgctgg cggagccgta      480

cacaccagag gactggattt cgccagcgac tgggtgctgg tagtggtggg gggggtcctg      540

gcctgctatt ctctgctcgt cacggtcgcc tttatcattt tttgggtgaa acggggtaga      600

aagaagctcc tctacatatt caaacagccg tttatgagac ccgttcagac tacccaagaa      660

gaggatgggt gtagttgccg ctttcccgag gaggaagagg gaggatgtga actgtgctgg      720

ctgaccaaaa agaaatactc atctagcgtt cacgacccga acggcgaata catgttcatg      780

cgagcggtaa acaccgcaaa gaaatcacgg ttgaccgacg taaccctt                   828


<210>  1074
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 v196  (vCD8) 41BB_41BB

<400>  1074
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttcgtgcta      120

aactggtatc gcatgagccc cagcaaccag acggacaagc tggccgcctt ccccgaggac      180

cgcaaccagc ccggccagga ccgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

taccacatga gcgtggacag ggcccggcgc aatgacagcg gcacatacct ctgtggggcc      300

atcactctgg cccccaaggt gcagatcgat gagagcctgc gtgtagagct cagggtgaca      360

gagagagcca agcctaccac cacccctgcc cctagacctc caacacccgc cccaacaatc      420

gccagccagc ctctgtctct gaggcccgag gcttgtagac cagctgctgg cggagccgta      480

cacaccagag gactggattt cgccagcgac atcatatcat tcttcttggc tctgacctct      540

acagctctgc tgttcctttt gttttttctc acactccgct tttctgtagt taaacggggt      600

agaaagaagc tcctctacat attcaaacag ccgtttatga gacccgttca gactacccaa      660

gaagaggatg ggtgtagttg ccgctttccc gaggaggaag agggaggatg tgaactg         717


<210>  1075
<211>  687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 v196  (vCD8) ICOS_ICOS

<400>  1075
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttcgtgcta      120

aactggtatc gcatgagccc cagcaaccag acggacaagc tggccgcctt ccccgaggac      180

cgcaaccagc ccggccagga ccgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

taccacatga gcgtggacag ggcccggcgc aatgacagcg gcacatacct ctgtggggcc      300

atcactctgg cccccaaggt gcagatcgat gagagcctgc gtgtagagct cagggtgaca      360

gagagagcca agcctaccac cacccctgcc cctagacctc caacacccgc cccaacaatc      420

gccagccagc ctctgtctct gaggcccgag gcttgtagac cagctgctgg cggagccgta      480

cacaccagag gactggattt cgccagcgac ttctggctcc ccatcggatg cgctgcgttc      540

gtcgttgtct gcattcttgg atgcatcctt atttgctggc tgaccaaaaa gaaatactca      600

tctagcgttc acgacccgaa cggcgaatac atgttcatgc gagcggtaaa caccgcaaag      660

aaatcacggt tgaccgacgt aaccctt                                          687


<210>  1076
<211>  600
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 v196  (vCD8) CD28_RSKS

<400>  1076
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttcgtgcta      120

aactggtatc gcatgagccc cagcaaccag acggacaagc tggccgcctt ccccgaggac      180

cgcaaccagc ccggccagga ccgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

taccacatga gcgtggacag ggcccggcgc aatgacagcg gcacatacct ctgtggggcc      300

atcactctgg cccccaaggt gcagatcgat gagagcctgc gtgtagagct cagggtgaca      360

gagagagcca agcctaccac cacccctgcc cctagacctc caacacccgc cccaacaatc      420

gccagccagc ctctgtctct gaggcccgag gcttgtagac cagctgctgg cggagccgta      480

cacaccagag gactggattt cgccagcgac tgggtgctgg tagtggtggg gggggtcctg      540

gcctgctatt ctctgctcgt cacggtcgcc tttatcattt tttgggtgcg gagtaagtcc      600


<210>  1077
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 v196  (CD8) CD28_CD28

<400>  1077
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttcgtgcta      120

aactggtatc gcatgagccc cagcaaccag acggacaagc tggccgcctt ccccgaggac      180

cgcaaccagc ccggccagga ccgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

taccacatga gcgtggacag ggcccggcgc aatgacagcg gcacatacct ctgtggggcc      300

atcactctgg cccccaaggt gcagatcgat gagagcctgc gtgtagagct cagggtgaca      360

gagagagcca agcctaccac cacccctgcc cctagacctc caacacccgc cccaacaatc      420

gccagccagc ctctgtctct gaggcccgag gcttgtagac cagctgctgg cggagccgta      480

cacaccagag gactggattt cgcctgcgac tgggtgctgg tagtggtggg gggggtcctg      540

gcctgctatt ctctgctcgt cacggtcgcc tttatcattt tttgggtgcg gagtaagaga      600

agccgcctcc tccacagcga ctacatgaat atgaccccgc gcaggccggg gcctacaaga      660

aagcattacc agccgtatgc tccaccacga gattttgctg cttacaggag c               711


<210>  1078
<211>  837
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 v196  (CD8) CD28_CD28/41BB

<400>  1078
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttcgtgcta      120

aactggtatc gcatgagccc cagcaaccag acggacaagc tggccgcctt ccccgaggac      180

cgcaaccagc ccggccagga ccgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

taccacatga gcgtggacag ggcccggcgc aatgacagcg gcacatacct ctgtggggcc      300

atcactctgg cccccaaggt gcagatcgat gagagcctgc gtgtagagct cagggtgaca      360

gagagagcca agcctaccac cacccctgcc cctagacctc caacacccgc cccaacaatc      420

gccagccagc ctctgtctct gaggcccgag gcttgtagac cagctgctgg cggagccgta      480

cacaccagag gactggattt cgcctgcgac tgggtgctgg tagtggtggg gggggtcctg      540

gcctgctatt ctctgctcgt cacggtcgcc tttatcattt tttgggtgcg gagtaagaga      600

agccgcctcc tccacagcga ctacatgaat atgaccccgc gcaggccggg gcctacaaga      660

aagcattacc agccgtatgc tccaccacga gattttgctg cttacaggag caaacggggt      720

agaaagaagc tcctctacat attcaaacag ccgtttatga gacccgttca gactacccaa      780

gaagaggatg ggtgtagttg ccgctttccc gaggaggaag agggaggatg tgaactg         837


<210>  1079
<211>  825
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 v196  (CD8) CD28_CD28/ICOS

<400>  1079
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttcgtgcta      120

aactggtatc gcatgagccc cagcaaccag acggacaagc tggccgcctt ccccgaggac      180

cgcaaccagc ccggccagga ccgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

taccacatga gcgtggacag ggcccggcgc aatgacagcg gcacatacct ctgtggggcc      300

atcactctgg cccccaaggt gcagatcgat gagagcctgc gtgtagagct cagggtgaca      360

gagagagcca agcctaccac cacccctgcc cctagacctc caacacccgc cccaacaatc      420

gccagccagc ctctgtctct gaggcccgag gcttgtagac cagctgctgg cggagccgta      480

cacaccagag gactggattt cgcctgcgac tgggtgctgg tagtggtggg gggggtcctg      540

gcctgctatt ctctgctcgt cacggtcgcc tttatcattt tttgggtgcg gagtaagaga      600

agccgcctcc tccacagcga ctacatgaat atgaccccgc gcaggccggg gcctacaaga      660

aagcattacc agccgtatgc tccaccacga gattttgctg cttacaggag ctgctggctg      720

accaaaaaga aatactcatc tagcgttcac gacccgaacg gcgaatacat gttcatgcga      780

gcggtaaaca ccgcaaagaa atcacggttg accgacgtaa ccctt                      825


<210>  1080
<211>  951
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 v196  (CD8) CD28_CD28/ICOS/41BB

<400>  1080
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttcgtgcta      120

aactggtatc gcatgagccc cagcaaccag acggacaagc tggccgcctt ccccgaggac      180

cgcaaccagc ccggccagga ccgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

taccacatga gcgtggacag ggcccggcgc aatgacagcg gcacatacct ctgtggggcc      300

atcactctgg cccccaaggt gcagatcgat gagagcctgc gtgtagagct cagggtgaca      360

gagagagcca agcctaccac cacccctgcc cctagacctc caacacccgc cccaacaatc      420

gccagccagc ctctgtctct gaggcccgag gcttgtagac cagctgctgg cggagccgta      480

cacaccagag gactggattt cgcctgcgac tgggtgctgg tagtggtggg gggggtcctg      540

gcctgctatt ctctgctcgt cacggtcgcc tttatcattt tttgggtgcg gagtaagaga      600

agccgcctcc tccacagcga ctacatgaat atgaccccgc gcaggccggg gcctacaaga      660

aagcattacc agccgtatgc tccaccacga gattttgctg cttacaggag ctgctggctg      720

accaaaaaga aatactcatc tagcgttcac gacccgaacg gcgaatacat gttcatgcga      780

gcggtaaaca ccgcaaagaa atcacggttg accgacgtaa cccttaaacg gggtagaaag      840

aagctcctct acatattcaa acagccgttt atgagacccg ttcagactac ccaagaagag      900

gatgggtgta gttgccgctt tcccgaggag gaagagggag gatgtgaact g               951


<210>  1081
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v201 (vCD8) 41BB_41BB

<400>  1081

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe His Val Ile Trp His Arg Glu Ser Pro Ser 
        35                  40                  45              


Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Ala Lys Pro Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Ile Ser Phe Phe Leu 
                165                 170                 175     


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
            180                 185                 190         


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
        195                 200                 205             


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
    210                 215                 220                 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
225                 230                 


<210>  1082
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v201 (vCD8) CD28_CD28/41BB

<400>  1082

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe His Val Ile Trp His Arg Glu Ser Pro Ser 
        35                  40                  45              


Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Ala Lys Pro Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Ser Asp Trp Val Leu Val Val Val 
                165                 170                 175     


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
            180                 185                 190         


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
        195                 200                 205             


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
    210                 215                 220                 


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly 
225                 230                 235                 240 


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
                245                 250                 255     


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
            260                 265                 270         


Glu Glu 
        


<210>  1083
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v201 (vCD8) 41BB_41BB/CD28

<400>  1083

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe His Val Ile Trp His Arg Glu Ser Pro Ser 
        35                  40                  45              


Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Ala Lys Pro Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Ser Asp Ile Ile Ser Phe Phe Leu 
                165                 170                 175     


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
            180                 185                 190         


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
        195                 200                 205             


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
    210                 215                 220                 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Arg Ser Lys Arg Ser Arg 
225                 230                 235                 240 


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
                245                 250                 255     


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            260                 265                 270         


Tyr Arg Ser 
        275 


<210>  1084
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 v201 (vCD8) ICOS_ICOS/41BB

<400>  1084

Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu 
1               5                   10                  15      


Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser 
            20                  25                  30          


Asn Thr Ser Glu Ser Phe His Val Ile Trp His Arg Glu Ser Pro Ser 
        35                  40                  45              


Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro 
    50                  55                  60                  


Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp 
65                  70                  75                  80  


Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr 
                85                  90                  95      


Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys Glu Ser 
            100                 105                 110         


Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Ala Lys Pro Thr Thr Thr 
        115                 120                 125             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    130                 135                 140                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
145                 150                 155                 160 


His Thr Arg Gly Leu Asp Phe Ala Ser Asp Phe Trp Leu Pro Ile Gly 
                165                 170                 175     


Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu Ile Cys 
            180                 185                 190         


Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly 
        195                 200                 205             


Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu 
    210                 215                 220                 


Thr Asp Val Thr Leu Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
225                 230                 235                 240 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                245                 250                 255     


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
            260                 265     


<210>  1085
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 v201 (vCD8) 41BB_41BB

<400>  1085
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttccacgtg      120

atctggcacc gcgaaagccc cagcggccag acggacacac tggccgcctt ccccgaggac      180

cgcagccagc ccggccagga ctgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

ttccacatga gcgtggtcag ggcccggcgc aatgacagcg gcacctacgt gtgtggggtg      300

atctccctgg cccccaagat ccagatcaaa gagagcctgc gggcagagct cagggtgaca      360

gagagagcca agcctaccac cacccctgcc cctagacctc caacacccgc cccaacaatc      420

gccagccagc ctctgtctct gaggcccgag gcttgtagac cagctgctgg cggagccgtg      480

cacaccagag gactggattt cgcctgcgac atcatatcat tcttcttggc tctgacctct      540

acagctctgc tgttcctttt gttttttctc acactccgct tttctgtagt taaacggggt      600

agaaagaagc tcctctacat attcaaacag ccgtttatga gacccgttca gactacccaa      660

gaagaggatg ggtgtagttg ccgctttccc gaggaggaag ag                         702


<210>  1086
<211>  822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 v201 (vCD8) CD28_CD28/41BB

<400>  1086
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttccacgtg      120

atctggcacc gcgaaagccc cagcggccag acggacacac tggccgcctt ccccgaggac      180

cgcagccagc ccggccagga ctgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

ttccacatga gcgtggtcag ggcccggcgc aatgacagcg gcacctacgt gtgtggggtg      300

atctccctgg cccccaagat ccagatcaaa gagagcctgc gggcagagct cagggtgaca      360

gagagagcca agcctaccac cacccctgcc cctagacctc caacacccgc cccaacaatc      420

gccagccagc ctctgtctct gaggcccgag gcttgtagac cagctgctgg cggagccgta      480

cacaccagag gactggattt cgccagcgac tgggtgctgg tagtggtggg gggggtcctg      540

gcctgctatt ctctgctcgt cacggtcgcc tttatcattt tttgggtgcg gagtaagaga      600

agccgcctcc tccacagcga ctacatgaat atgaccccgc gcaggccggg gcctacaaga      660

aagcattacc agccgtatgc tccaccacga gattttgctg cttacaggag caaacggggt      720

agaaagaagc tcctctacat attcaaacag ccgtttatga gacccgttca gactacccaa      780

gaagaggatg ggtgtagttg ccgctttccc gaggaggaag ag                         822


<210>  1087
<211>  831
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 v201 (vCD8) 41BB_41BB/CD28

<400>  1087
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttccacgtg      120

atctggcacc gcgaaagccc cagcggccag acggacacac tggccgcctt ccccgaggac      180

cgcagccagc ccggccagga ctgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

ttccacatga gcgtggtcag ggcccggcgc aatgacagcg gcacctacgt gtgtggggtg      300

atctccctgg cccccaagat ccagatcaaa gagagcctgc gggcagagct cagggtgaca      360

gagagagcca agcctaccac cacccctgcc cctagacctc caacacccgc cccaacaatc      420

gccagccagc ctctgtctct gaggcccgag gcttgtagac cagctgctgg cggagccgta      480

cacaccagag gactggattt cgccagcgac ccgcagatca tatcattctt cttggctctg      540

acctctacag ctctgctgtt ccttttgttt tttctcacac tccgcttttc tgtagttaaa      600

cggggtagaa agaagctcct ctacatattc aaacagccgt ttatgagacc cgttcagact      660

acccaagaag aggatgggtg tagttgccgc tttcccgagg aggaagagcg gagtaagaga      720

agccgcctcc tccacagcga ctacatgaat atgaccccgc gcaggccggg gcctacaaga      780

aagcattacc agccgtatgc tccaccacga gattttgctg cttacaggag c               831


<210>  1088
<211>  804
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 v201 (vCD8) ICOS_ICOS/41BB

<400>  1088
gactccccag acaggccctg gaaccccccc accttctccc cagccctgct cgtggtgacc       60

gaaggggaca acgccacctt cacctgcagc ttctccaaca catcggagag cttccacgtg      120

atctggcacc gcgaaagccc cagcggccag acggacacac tggccgcctt ccccgaggac      180

cgcagccagc ccggccagga ctgccgcttc cgtgtcacac aactgcccaa cgggcgtgac      240

ttccacatga gcgtggtcag ggcccggcgc aatgacagcg gcacctacgt gtgtggggtg      300

atctccctgg cccccaagat ccagatcaaa gagagcctgc gggcagagct cagggtgaca      360

gagagagcca agcctaccac cacccctgcc cctagacctc caacacccgc cccaacaatc      420

gccagccagc ctctgtctct gaggcccgag gcttgtagac cagctgctgg cggagccgtg      480

cacaccagag gactggattt cgcctgcgac ttgaaattct ggctccccat cggatgcgct      540

gcgttcgtcg ttgtctgcat tcttggatgc atccttattt gctggctgac caaaaagaaa      600

tactcatcta gcgttcacga cccgaacggc gaatacatgt tcatgcgagc ggtaaacacc      660

gcaaagaaat cacggttgac cgacgtaacc cttaaacggg gtagaaagaa gctcctctac      720

atattcaaac agccgtttat gagacccgtt cagactaccc aagaagagga tgggtgtagt      780

tgccgctttc ccgaggagga agag                                             804


<210>  1089
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD86 WT ECD/PD1v179 ECD (6-127) Stack v1

<400>  1089

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly 
                85                  90                  95      


Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
            100                 105                 110         


Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val 
        115                 120                 125             


Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys 
    130                 135                 140                 


Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp 
145                 150                 155                 160 


Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val 
                165                 170                 175     


Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr 
            180                 185                 190         


Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro 
        195                 200                 205             


Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
225                 230                 235                 240 


Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu 
                245                 250                 255     


Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn 
            260                 265                 270         


Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn 
        275                 280                 285             


Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro Gly 
    290                 295                 300                 


Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Tyr 
305                 310                 315                 320 


His Met Ser Val Asp Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu 
                325                 330                 335     


Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser Leu 
            340                 345                 350         


Arg Val Glu Leu Arg Val Thr Glu Arg 
        355                 360     


<210>  1090
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD86 ECD v1 /PD1v179 ECD (6-127) Stack v2

<400>  1090

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Val Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Leu Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Gln Cys Ile Ile Leu His Lys Lys Pro Thr Gly 
                85                  90                  95      


Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
            100                 105                 110         


Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val 
        115                 120                 125             


Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys 
    130                 135                 140                 


Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp 
145                 150                 155                 160 


Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val 
                165                 170                 175     


Ser Ile Ser Leu Pro Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr 
            180                 185                 190         


Ile Phe Cys Ile Met Glu Thr Asp Lys Thr Arg Leu Leu Thr Ser Pro 
        195                 200                 205             


Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
225                 230                 235                 240 


Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu 
                245                 250                 255     


Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn 
            260                 265                 270         


Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn 
        275                 280                 285             


Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro Gly 
    290                 295                 300                 


Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Tyr 
305                 310                 315                 320 


His Met Ser Val Asp Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu 
                325                 330                 335     


Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser Leu 
            340                 345                 350         


Arg Val Glu Leu Arg Val Thr Glu Arg 
        355                 360     


<210>  1091
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD86 ECD v2 /PD1v179 ECD (6-127) Stack v3

<400>  1091

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Leu Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Gln Cys Ile Ile Leu His Lys Thr Pro Thr Gly 
                85                  90                  95      


Leu Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
            100                 105                 110         


Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val 
        115                 120                 125             


Tyr Ile Asn Leu Ala Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys 
    130                 135                 140                 


Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp 
145                 150                 155                 160 


Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val 
                165                 170                 175     


Ser Ile Ser Leu Pro Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr 
            180                 185                 190         


Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro 
        195                 200                 205             


Phe Ser Ile Glu Leu Glu Val Pro Gln Pro Pro Pro Asp His Ile Pro 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
225                 230                 235                 240 


Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu 
                245                 250                 255     


Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn 
            260                 265                 270         


Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn 
        275                 280                 285             


Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro Gly 
    290                 295                 300                 


Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Tyr 
305                 310                 315                 320 


His Met Ser Val Asp Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu 
                325                 330                 335     


Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser Leu 
            340                 345                 350         


Arg Val Glu Leu Arg Val Thr Glu Arg 
        355                 360     


<210>  1092
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD86 ECD v3 /PD1v179 ECD (6-127) Stack v4

<400>  1092

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Leu Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Arg Cys Ile Ile Leu His Lys Lys Pro Thr Gly 
                85                  90                  95      


Met Ile Arg Ile His Gln Met Ser Ser Glu Leu Ser Val Leu Ala Asn 
            100                 105                 110         


Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val 
        115                 120                 125             


Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys 
    130                 135                 140                 


Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp 
145                 150                 155                 160 


Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val 
                165                 170                 175     


Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr 
            180                 185                 190         


Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro 
        195                 200                 205             


Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
225                 230                 235                 240 


Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu 
                245                 250                 255     


Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn 
            260                 265                 270         


Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn 
        275                 280                 285             


Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro Gly 
    290                 295                 300                 


Gln Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Tyr 
305                 310                 315                 320 


His Met Ser Val Asp Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu 
                325                 330                 335     


Cys Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser Leu 
            340                 345                 350         


Arg Val Glu Leu Arg Val Thr Glu Arg 
        355                 360     


<210>  1093
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD86 IgV v4 /PD1v179 ECD (6-127) Stack v5

<400>  1093

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly 
                85                  90                  95      


Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ser 
        115                 120                 125             


Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val 
    130                 135                 140                 


Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr 
145                 150                 155                 160 


Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln 
                165                 170                 175     


Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro Gly Gln 
            180                 185                 190         


Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Tyr His 
        195                 200                 205             


Met Ser Val Asp Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys 
    210                 215                 220                 


Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser Leu Arg 
225                 230                 235                 240 


Val Glu Leu Arg Val Thr Glu Arg 
                245             


<210>  1094
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD86 IgV v5 /PD1v179 ECD (6-127) Stack v6

<400>  1094

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Val Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Leu Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Gln Cys Ile Ile Leu His Lys Lys Pro Thr Gly 
                85                  90                  95      


Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ser 
        115                 120                 125             


Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val 
    130                 135                 140                 


Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr 
145                 150                 155                 160 


Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln 
                165                 170                 175     


Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro Gly Gln 
            180                 185                 190         


Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Tyr His 
        195                 200                 205             


Met Ser Val Asp Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys 
    210                 215                 220                 


Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser Leu Arg 
225                 230                 235                 240 


Val Glu Leu Arg Val Thr Glu Arg 
                245             


<210>  1095
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD86 IgV v6 /PD1v179 ECD (6-127) Stack v7

<400>  1095

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Leu Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Gln Cys Ile Ile Leu His Lys Thr Pro Thr Gly 
                85                  90                  95      


Leu Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ser 
        115                 120                 125             


Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val 
    130                 135                 140                 


Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr 
145                 150                 155                 160 


Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln 
                165                 170                 175     


Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro Gly Gln 
            180                 185                 190         


Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Tyr His 
        195                 200                 205             


Met Ser Val Asp Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys 
    210                 215                 220                 


Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser Leu Arg 
225                 230                 235                 240 


Val Glu Leu Arg Val Thr Glu Arg 
                245             


<210>  1096
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD86 IgV v7 /PD1v179 ECD (6-127) Stack v8

<400>  1096

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Leu Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Arg Cys Ile Ile Leu His Lys Lys Pro Thr Gly 
                85                  90                  95      


Met Ile Arg Ile His Gln Met Ser Ser Glu Leu Ser Val Leu Ala Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ser 
        115                 120                 125             


Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val 
    130                 135                 140                 


Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr 
145                 150                 155                 160 


Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln 
                165                 170                 175     


Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Asn Gln Pro Gly Gln 
            180                 185                 190         


Asp Arg Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Tyr His 
        195                 200                 205             


Met Ser Val Asp Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys 
    210                 215                 220                 


Gly Ala Ile Thr Leu Ala Pro Lys Val Gln Ile Asp Glu Ser Leu Arg 
225                 230                 235                 240 


Val Glu Leu Arg Val Thr Glu Arg 
                245             


<210>  1097
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD86 ECD v5

<400>  1097

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Val Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Leu Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Gln Cys Ile Ile Leu His Lys Lys Pro Thr Gly 
                85                  90                  95      


Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
            100                 105                 110         


Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val 
        115                 120                 125             


Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys 
    130                 135                 140                 


Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp 
145                 150                 155                 160 


Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val 
                165                 170                 175     


Ser Ile Ser Leu Pro Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr 
            180                 185                 190         


Ile Phe Cys Ile Met Glu Thr Asp Lys Thr Arg Leu Leu Thr Ser Pro 
        195                 200                 205             


Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro 
    210                 215                 220                 


<210>  1098
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD86 ECD v9

<400>  1098

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Leu Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Gln Cys Ile Ile Leu His Lys Thr Pro Thr Gly 
                85                  90                  95      


Leu Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
            100                 105                 110         


Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val 
        115                 120                 125             


Tyr Ile Asn Leu Ala Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys 
    130                 135                 140                 


Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp 
145                 150                 155                 160 


Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val 
                165                 170                 175     


Ser Ile Ser Leu Pro Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr 
            180                 185                 190         


Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro 
        195                 200                 205             


Phe Ser Ile Glu Leu Glu Val Pro Gln Pro Pro Pro Asp His Ile Pro 
    210                 215                 220                 


<210>  1099
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD86 ECD v10

<400>  1099

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Leu Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Arg Cys Ile Ile Leu His Lys Lys Pro Thr Gly 
                85                  90                  95      


Met Ile Arg Ile His Gln Met Ser Ser Glu Leu Ser Val Leu Ala Asn 
            100                 105                 110         


Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val 
        115                 120                 125             


Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys 
    130                 135                 140                 


Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp 
145                 150                 155                 160 


Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val 
                165                 170                 175     


Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr 
            180                 185                 190         


Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro 
        195                 200                 205             


Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro 
    210                 215                 220                 


<210>  1100
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD86(B7-2) IgV (24-134)

<400>  1100

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly 
                85                  90                  95      


Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala 
            100                 105                 110     


<210>  1101
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD86 IgV v55

<400>  1101

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Val Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Leu Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Gln Cys Ile Ile Leu His Lys Lys Pro Thr Gly 
                85                  90                  95      


Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala 
            100                 105                 110     


<210>  1102
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD86 IgV v59

<400>  1102

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Leu Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Gln Cys Ile Ile Leu His Lys Thr Pro Thr Gly 
                85                  90                  95      


Leu Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala 
            100                 105                 110     


<210>  1103
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD86 IgV v60

<400>  1103

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Leu Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Arg Cys Ile Ile Leu His Lys Lys Pro Thr Gly 
                85                  90                  95      


Met Ile Arg Ile His Gln Met Ser Ser Glu Leu Ser Val Leu Ala 
            100                 105                 110     


<210>  1104
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD86(B7-2) IgV WT

<400>  1104

Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln 
1               5                   10                  15      


Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln Glu Asn Leu Val 
            20                  25                  30          


Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe Asp Ser Val His Ser 
        35                  40                  45              


Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg 
    50                  55                  60                  


Leu His Asn Leu Gln Ile Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile 
65                  70                  75                  80  


His His Lys Lys Pro Thr Gly Met Ile Arg Ile His Gln Met Asn Ser 
                85                  90                  95      


Glu Leu Ser 
            


