                         SEQUENCE LISTING

<110>  City of Hope
       Kortylewski, Marcin
       Swiderski, Piotr M
       Rosen, Steven
 
<120>  Oligonucleotide-Based Proteolysis Targeting Chimera

<130>  048440-699001WO

<140>  PCT/US2019/037447
<141>  2019-06-17

<150>  US 62/685,810
<151>  2018-06-15

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  ((CH2)3)5

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (39)..(40)
<223>  ((CH2)3)4

<220>
<221>  misc_feature
<222>  (51)..(52)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (52)..(53)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (53)..(54)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  3' C6 amino linker

<400>  1
tcgtcgtttt gtcgttttgt cgttcatttc ccgtaaatcg atttacggga aatg             54


<210>  2
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  ((CH2)3)5

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (39)..(40)
<223>  ((CH2)3)4

<220>
<221>  misc_feature
<222>  (51)..(52)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (52)..(53)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (53)..(54)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  3' C6 amino linker

<400>  2
tcgtcgtttt gtcgttttgt cgttcatttc ccgtaaatcg atttacggga aatg             54


<210>  3
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  ((CH2)3)5

<220>
<221>  misc_feature
<222>  (25)..(26)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (26)..(27)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (39)..(40)
<223>  ((CH2)3)4

<220>
<221>  misc_feature
<222>  (51)..(52)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (52)..(53)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (53)..(54)
<223>  internal phosphorothioation

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  3' C6 amino linker

<400>  3
tcgtcgtttt gtcgttttgt cgttcatttc ccgtaaatcg atttacggga aatg             54


<210>  4
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  ((CH2)3)5

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  ((CH2)3)4

<220>
<221>  misc_feature
<222>  (47)..(48)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (48)..(49)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (49)..(50)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  ((CH2)3)5

<400>  4
ggtgcatcga tgcagggggg catttcccgt aaatcgattt acgggaaatg                  50


<210>  5
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  ((CH2)3)5

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  ((CH2)3)4

<220>
<221>  misc_feature
<222>  (47)..(48)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (48)..(49)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (49)..(50)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  ((CH2)3)5

<400>  5
ggtgcatgca tgcagggggg catttcccgt aaatcgattt acgggaaatg                  50


<210>  6
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  ((CH2)3)5

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  ((CH2)3)4

<220>
<221>  misc_feature
<222>  (47)..(48)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (48)..(49)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (49)..(50)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  ((CH2)3)5

<400>  6
ggtgcatcga tgcagggggg actcttgcca attacgtaat tggcaagagt                  50


<210>  7
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  ((CH2)3)5

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  ((CH2)3)4

<220>
<221>  misc_feature
<222>  (47)..(48)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (48)..(49)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (49)..(50)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  ((CH2)3)5

<400>  7
tccatgacgt tcctgatgct catttcccgt aaatcgattt acgggaaatg                  50


<210>  8
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  ((CH2)3)5

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  ((CH2)3)4

<220>
<221>  misc_feature
<222>  (47)..(48)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (48)..(49)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (49)..(50)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  ((CH2)3)5

<400>  8
tccatgacgt tcctgatgct catttccctt aaatcgattt aagggaaatg                  50


<210>  9
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  (CH2)3)5

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (35)..(36)
<223>  (CH2)3)4

<220>
<221>  misc_feature
<222>  (47)..(48)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (48)..(49)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (49)..(50)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  (CH2)3)5

<400>  9
tccatgacgt tcctgatgct actcttgcca attacgtaat tggcaagagt                  50


<210>  10
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  ((CH2)3)5

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  ((CH2)3)4

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (28)..(29)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  ((CH2)3)5

<400>  10
catttcccgt aaatcgattt acgggaaatg                                        30


<210>  11
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  phosphorothioate linkage

<400>  11
ggggtcaacg ttgagggggg                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  phosphorothioate linkage

<400>  12
ggggtcaacg ttgagggggg                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  phosphorothioate linkage

<400>  13
gggggacgat cgtcgggggg                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  phosphorothioate linkage

<400>  14
gggggacgat cgtcgggggg                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  phosphorothioate linkage

<400>  15
ggtgcatcga tgcagggggg                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  phosphorothioate linkage

<400>  16
ggtgcatcga tgcagggggg                                                   20


<210>  17
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  17
ggggacgacg tcgtgggggg g                                                 21


<210>  18
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  18
ggggacgacg tcgtgggggg g                                                 21


<210>  19
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  phosphorothioate linkage

<400>  19
tccatgacgt tcctgatgct                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  phosphorothioate linkage

<400>  20
tccatgacgt tcctgacgtt                                                   20


<210>  21
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  phosphorothioate linkage

<400>  21
tcgtcgtttt gtcgttttgt cgtt                                              24


<210>  22
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  phosphorothioate linkage

<400>  22
tcgtcgttgt cgttttgtcg tt                                                22


<210>  23
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  phosphorothioate linkage

<400>  23
tcgtcgtttt cggcgcgcgc cg                                                22


<210>  24
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (22)..(23)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (24)..(25)
<223>  phosphorothioate linkage

<400>  24
tcgtcgtcgt tcgaacgacg ttgat                                             25


