
                                SEQUENCE LISTING

<110> Regeneron Pharmaceuticals, Inc.

<120> Anti-FXII/FXIIa Antibodies and Uses Thereof

<130> 118003-10720

<140>
<141>

<150> 62/687,144
<151> 2018-06-19

<160> 65

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 375
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 1
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgacggtt 60
tcctgcaagg catctggata caccttcacc agctactatt tgcactgggt gcgacaggcc 120
cctggacaag gacttgagtg gatgggaata atcaacccca gtggtggtag cacaagctac 180
gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac 240
atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggcgtg 300
actacagtga ctacttacta ccactactac aatatggacg tctggggcca agggaccacg 360
gtcaccgtct cctca                                                  375

<210> 2
<211> 125
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 2
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Thr Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Val Thr Thr Val Thr Thr Tyr Tyr His Tyr Tyr Asn Met
            100                 105                 110         
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120                 125 


<210> 3
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 3
ggatacacct tcaccagcta ctat                                        24

<210> 4
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 4
Gly Tyr Thr Phe Thr Ser Tyr Tyr
 1               5              


<210> 5
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 5
atcaacccca gtggtggtag caca                                        24

<210> 6
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 6
Ile Asn Pro Ser Gly Gly Ser Thr
 1               5              


<210> 7
<211> 54
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 7
gcgagaggcg tgactacagt gactacttac taccactact acaatatgga cgtc       54

<210> 8
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 8
Ala Arg Gly Val Thr Thr Val Thr Thr Tyr Tyr His Tyr Tyr Asn Met
 1               5                  10                  15      
Asp Val
        


<210> 9
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 9
gacatccaga tgacccagtc tccatcctca ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgtc gggcgagtca gggcattagc aattatttag cctggtttca gcagaaacca 120
gggaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180
aagttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240
gaagattttg caacttatta ctgccaaaag tataatactt accctctcac tttcggcgga 300
gggaccaagg tggagatcaa a                                           321

<210> 10
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 10
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr
            20                  25                  30          
Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Lys Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Lys Tyr Asn Thr Tyr Pro Leu
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 11
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 11
cagggcatta gcaattat                                               18

<210> 12
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 12
Gln Gly Ile Ser Asn Tyr
 1               5      


<210> 13
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 13
gctgcatcc                                                         9

<210> 14
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 14
Ala Ala Ser
 1          


<210> 15
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 15
caaaagtata atacttaccc tctcact                                     27

<210> 16
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 16
Gln Lys Tyr Asn Thr Tyr Pro Leu Thr
 1               5                  


<210> 17
<211> 363
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 17
gaggtgcagc tggtggagtc tgggggaggc ttggtgcagc ctcgggggtc cctgagactc 60
tcctgtgtgg cctctggatt cacctttagc gactatggca tgagttgggt ccgacaggct 120
ccagggaagg ggctggagtg ggtctcagtt attggtggtg ctggtcatgg cacatattac 180
gctgactccg tgaagggccg gttcaccatc tccagagaca attccaggaa cacgttgtat 240
ctgcaaatga acagcctgag agacgaggac acggccgtat attattgtgc gaaaaaatat 300
tactggaact acgtcggcgg tatggacgtc tggggccgag ggaccacggt caccgtctcc 360
tca                                                               363

<210> 18
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 18
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Arg Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Val Ile Gly Gly Ala Gly His Gly Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Lys Lys Tyr Tyr Trp Asn Tyr Val Gly Gly Met Asp Val Trp Gly
            100                 105                 110         
Arg Gly Thr Thr Val Thr Val Ser Ser
        115                 120     


<210> 19
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 19
ggattcacct ttagcgacta tggc                                        24

<210> 20
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 20
Gly Phe Thr Phe Ser Asp Tyr Gly
 1               5              


<210> 21
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 21
attggtggtg ctggtcatgg caca                                        24

<210> 22
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 22
Ile Gly Gly Ala Gly His Gly Thr
 1               5              


<210> 23
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 23
gcgaaaaaat attactggaa ctacgtcggc ggtatggacg tc                    42

<210> 24
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 24
Ala Lys Lys Tyr Tyr Trp Asn Tyr Val Gly Gly Met Asp Val
 1               5                  10                  


<210> 25
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 25
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc 60
atcacttgtc gggcgagtca ggatattaac aactggttag cctggtatca gcagaaacca 120
gggaaagccc ctaaactcct gatctctact gcatccagtt tgcaaagtgg ggtcccatca 180
aggttcagcg gcagtggatc tgggacagac ttcactctca ccatcagtag cctacagcct 240
gaagattttg caacttacta ttgtcaacag gctaacagtc tcccattcac tttcggccct 300
gggaccaaag tggatatcaa a                                           321

<210> 26
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 26
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Asn Asn Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Ser Thr Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Leu Pro Phe
                85                  90                  95      
Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
            100                 105         


<210> 27
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 27
caggatatta acaactgg                                               18

<210> 28
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 28
Gln Asp Ile Asn Asn Trp
 1               5      


<210> 29
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 29
actgcatcc                                                         9

<210> 30
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 30
Thr Ala Ser
 1          


<210> 31
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 31
caacaggcta acagtctccc attcact                                     27

<210> 32
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 32
Gln Gln Ala Asn Ser Leu Pro Phe Thr
 1               5                  


<210> 33
<211> 345
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 33
gaggtgcagc tggtggagtc tgggggagac ttggtccagc ctggggggtc cctgagactc 60
tcctgtgcag cctctggatt caccttcaat acctatgcta tgcactgggt ccgccaggct 120
ccagggaagg gactggaata tatttcagct attgatacca aagggggttc cacatattat 180
gcagactctg tgaagggcag attcaccatt tccagagaca attccaagaa cgcgcagtat 240
cttcaaatgg acagcctgag agttgaagac atggctgttt attattgtgc gagagggttc 300
ggtctggacg tctggggcca agggaccacg gtcaccgtct cctca                 345

<210> 34
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 34
Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile
        35                  40                  45              
Ser Ala Ile Asp Thr Lys Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ala Gln Tyr
65                  70                  75                  80  
Leu Gln Met Asp Ser Leu Arg Val Glu Asp Met Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Phe Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr
            100                 105                 110         
Val Ser Ser
        115 


<210> 35
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 35
ggattcacct tcaataccta tgct                                        24

<210> 36
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 36
Gly Phe Thr Phe Asn Thr Tyr Ala
 1               5              


<210> 37
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 37
attgatacca aagggggttc caca                                        24

<210> 38
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 38
Ile Asp Thr Lys Gly Gly Ser Thr
 1               5              


<210> 39
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 39
gcgagagggt tcggtctgga cgtc                                        24

<210> 40
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 40
Ala Arg Gly Phe Gly Leu Asp Val
 1               5              


<210> 41
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 41
gatgttgtga tgacccagtc tccactctcc ctggccgtca cccttggaca gccggcctcc 60
atctcctgca ggtctagtca aagcctcgga tacagtgatg gaaacaccta cttgaattgg 120
tttcaacaga ggccaggcca atctccaagg cgcctaattt ataaggtttc taaccgggac 180
tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgacttcac actgaaaatc 240
aatagggtgg agactgtgga tgttggggtt tactactgca tgcaagctac acactggccg 300
tacacttttg gccaggggac caagctggag atcaaa                           336

<210> 42
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 42
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Ala Val Thr Leu Gly
 1               5                  10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Gly Tyr Ser
            20                  25                  30          
Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser
        35                  40                  45              
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Asn Arg Val Glu Thr Val Asp Val Gly Val Tyr Tyr Cys Met Gln Ala
                85                  90                  95      
Thr His Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 43
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 43
caaagcctcg gatacagtga tggaaacacc tac                              33

<210> 44
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 44
Gln Ser Leu Gly Tyr Ser Asp Gly Asn Thr Tyr
 1               5                  10      


<210> 45
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 45
aaggtttct                                                         9

<210> 46
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 46
Lys Val Ser
 1          


<210> 47
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 47
atgcaagcta cacactggcc gtacact                                     27

<210> 48
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 48
Met Gln Ala Thr His Trp Pro Tyr Thr
 1               5                  


<210> 49
<211> 372
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 49
caggtacagc tgcagcagtc aggtccagga ctggtgaagc cctcgcagac cctctcactc 60
acctgtgcca tctccgggga cagtgtctct agcaatagtg ctgcttggaa ttggatcagg 120
cagtccccct cgagaggcct tgagtggctg ggaaggacat actacaggtc caagtggttt 180
aatgattatg cagtgtctgt gaaaagtcga ataatcatca acccagacac aaccaagaac 240
cagttctccc tgcaggtgaa ctctgtgact cccgaagaca cggctgtgta ttactgtgca 300
agaggagagc cagctcgtcg gggtgaatac ttccaccact ggggccaggg caccctggtc 360
accgtctcct ca                                                     372

<210> 50
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 50
Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn
            20                  25                  30          
Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu
        35                  40                  45              
Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Phe Asn Asp Tyr Ala
    50                  55                  60                  
Val Ser Val Lys Ser Arg Ile Ile Ile Asn Pro Asp Thr Thr Lys Asn
65                  70                  75                  80  
Gln Phe Ser Leu Gln Val Asn Ser Val Thr Pro Glu Asp Thr Ala Val
                85                  90                  95      
Tyr Tyr Cys Ala Arg Gly Glu Pro Ala Arg Arg Gly Glu Tyr Phe His
            100                 105                 110         
His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 


<210> 51
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 51
ggggacagtg tctctagcaa tagtgctgct                                  30

<210> 52
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 52
Gly Asp Ser Val Ser Ser Asn Ser Ala Ala
 1               5                  10  


<210> 53
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 53
acatactaca ggtccaagtg gtttaat                                     27

<210> 54
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 54
Thr Tyr Tyr Arg Ser Lys Trp Phe Asn
 1               5                  


<210> 55
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 55
gcaagaggag agccagctcg tcggggtgaa tacttccacc ac                    42

<210> 56
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 56
Ala Arg Gly Glu Pro Ala Arg Arg Gly Glu Tyr Phe His His
 1               5                  10                  


<210> 57
<211> 324
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 57
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60
ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa 120
cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca 180
gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240
cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccttg gacgttcggc 300
caagggacca aggtggaaat caaa                                        324

<210> 58
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 58
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
        35                  40                  45              
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro
                85                  90                  95      
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105             


<210> 59
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 59
cagagtgtta gcagcagcta c                                           21

<210> 60
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 60
Gln Ser Val Ser Ser Ser Tyr
 1               5          


<210> 61
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 61
ggtgcatcc                                                         9

<210> 62
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 62
Gly Ala Ser
 1          


<210> 63
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 63
cagcagtatg gtagctcacc ttggacg                                     27

<210> 64
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic

<400> 64
Gln Gln Tyr Gly Ser Ser Pro Trp Thr
 1               5                  


<210> 65
<211> 615
<212> PRT
<213> Homo sapiens

<400> 65
Met Arg Ala Leu Leu Leu Leu Gly Phe Leu Leu Val Ser Leu Glu Ser
 1               5                  10                  15      
Thr Leu Ser Ile Pro Pro Trp Glu Ala Pro Lys Glu His Lys Tyr Lys
            20                  25                  30          
Ala Glu Glu His Thr Val Val Leu Thr Val Thr Gly Glu Pro Cys His
        35                  40                  45              
Phe Pro Phe Gln Tyr His Arg Gln Leu Tyr His Lys Cys Thr His Lys
    50                  55                  60                  
Gly Arg Pro Gly Pro Gln Pro Trp Cys Ala Thr Thr Pro Asn Phe Asp
65                  70                  75                  80  
Gln Asp Gln Arg Trp Gly Tyr Cys Leu Glu Pro Lys Lys Val Lys Asp
                85                  90                  95      
His Cys Ser Lys His Ser Pro Cys Gln Lys Gly Gly Thr Cys Val Asn
            100                 105                 110         
Met Pro Ser Gly Pro His Cys Leu Cys Pro Gln His Leu Thr Gly Asn
        115                 120                 125             
His Cys Gln Lys Glu Lys Cys Phe Glu Pro Gln Leu Leu Arg Phe Phe
    130                 135                 140                 
His Lys Asn Glu Ile Trp Tyr Arg Thr Glu Gln Ala Ala Val Ala Arg
145                 150                 155                 160 
Cys Gln Cys Lys Gly Pro Asp Ala His Cys Gln Arg Leu Ala Ser Gln
                165                 170                 175     
Ala Cys Arg Thr Asn Pro Cys Leu His Gly Gly Arg Cys Leu Glu Val
            180                 185                 190         
Glu Gly His Arg Leu Cys His Cys Pro Val Gly Tyr Thr Gly Ala Phe
        195                 200                 205             
Cys Asp Val Asp Thr Lys Ala Ser Cys Tyr Asp Gly Arg Gly Leu Ser
    210                 215                 220                 
Tyr Arg Gly Leu Ala Arg Thr Thr Leu Ser Gly Ala Pro Cys Gln Pro
225                 230                 235                 240 
Trp Ala Ser Glu Ala Thr Tyr Arg Asn Val Thr Ala Glu Gln Ala Arg
                245                 250                 255     
Asn Trp Gly Leu Gly Gly His Ala Phe Cys Arg Asn Pro Asp Asn Asp
            260                 265                 270         
Ile Arg Pro Trp Cys Phe Val Leu Asn Arg Asp Arg Leu Ser Trp Glu
        275                 280                 285             
Tyr Cys Asp Leu Ala Gln Cys Gln Thr Pro Thr Gln Ala Ala Pro Pro
    290                 295                 300                 
Thr Pro Val Ser Pro Arg Leu His Val Pro Leu Met Pro Ala Gln Pro
305                 310                 315                 320 
Ala Pro Pro Lys Pro Gln Pro Thr Thr Arg Thr Pro Pro Gln Ser Gln
                325                 330                 335     
Thr Pro Gly Ala Leu Pro Ala Lys Arg Glu Gln Pro Pro Ser Leu Thr
            340                 345                 350         
Arg Asn Gly Pro Leu Ser Cys Gly Gln Arg Leu Arg Lys Ser Leu Ser
        355                 360                 365             
Ser Met Thr Arg Val Val Gly Gly Leu Val Ala Leu Arg Gly Ala His
    370                 375                 380                 
Pro Tyr Ile Ala Ala Leu Tyr Trp Gly His Ser Phe Cys Ala Gly Ser
385                 390                 395                 400 
Leu Ile Ala Pro Cys Trp Val Leu Thr Ala Ala His Cys Leu Gln Asp
                405                 410                 415     
Arg Pro Ala Pro Glu Asp Leu Thr Val Val Leu Gly Gln Glu Arg Arg
            420                 425                 430         
Asn His Ser Cys Glu Pro Cys Gln Thr Leu Ala Val Arg Ser Tyr Arg
        435                 440                 445             
Leu His Glu Ala Phe Ser Pro Val Ser Tyr Gln His Asp Leu Ala Leu
    450                 455                 460                 
Leu Arg Leu Gln Glu Asp Ala Asp Gly Ser Cys Ala Leu Leu Ser Pro
465                 470                 475                 480 
Tyr Val Gln Pro Val Cys Leu Pro Ser Gly Ala Ala Arg Pro Ser Glu
                485                 490                 495     
Thr Thr Leu Cys Gln Val Ala Gly Trp Gly His Gln Phe Glu Gly Ala
            500                 505                 510         
Glu Glu Tyr Ala Ser Phe Leu Gln Glu Ala Gln Val Pro Phe Leu Ser
        515                 520                 525             
Leu Glu Arg Cys Ser Ala Pro Asp Val His Gly Ser Ser Ile Leu Pro
    530                 535                 540                 
Gly Met Leu Cys Ala Gly Phe Leu Glu Gly Gly Thr Asp Ala Cys Gln
545                 550                 555                 560 
Gly Asp Ser Gly Gly Pro Leu Val Cys Glu Asp Gln Ala Ala Glu Arg
                565                 570                 575     
Arg Leu Thr Leu Gln Gly Ile Ile Ser Trp Gly Ser Gly Cys Gly Asp
            580                 585                 590         
Arg Asn Lys Pro Gly Val Tyr Thr Asp Val Ala Tyr Tyr Leu Ala Trp
        595                 600                 605             
Ile Arg Glu His Thr Val Ser
    610                 615 

