                               SEQUENCE LISTING

<110> PRESIDENT AND FELLOWS OF HARVARD COLLEGE
 
<120> FIBROUS PROTEINACEOUS NETWORKS AND METHODS OF USE THEREOF

<130> 117823-18320

<140>
<141>

<150> 62/687,991
<151> 2018-06-21

<160> 13    

<170> PatentIn version 3.5

<210> 1
<211> 151
<212> PRT
<213> Escherichia coli

<400> 1
Met Lys Leu Leu Lys Val Ala Ala Ile Ala Ala Ile Val Phe Ser Gly 
1               5                   10                  15      


Ser Ala Leu Ala Gly Val Val Pro Gln Tyr Gly Gly Gly Gly Asn His 
            20                  25                  30          


Gly Gly Gly Gly Asn Asn Ser Gly Pro Asn Ser Glu Leu Asn Ile Tyr 
        35                  40                  45              


Gln Tyr Gly Gly Gly Asn Ser Ala Leu Ala Leu Gln Thr Asp Ala Arg 
    50                  55                  60                  


Asn Ser Asp Leu Thr Ile Thr Gln His Gly Gly Gly Asn Gly Ala Asp 
65                  70                  75                  80  


Val Gly Gln Gly Ser Asp Asp Ser Ser Ile Asp Leu Thr Gln Arg Gly 
                85                  90                  95      


Phe Gly Asn Ser Ala Thr Leu Asp Gln Trp Asn Gly Lys Asn Ser Glu 
            100                 105                 110         


Met Thr Val Lys Gln Phe Gly Gly Gly Asn Gly Ala Ala Val Asp Gln 
        115                 120                 125             


Thr Ala Ser Asn Ser Ser Val Asn Val Thr Gln Val Gly Phe Gly Asn 
    130                 135                 140                 


Asn Ala Thr Ala His Gln Tyr 
145                 150     


<210> 2
<211> 590
<212> PRT
<213> Homo sapiens

<400> 2
Met Ser Arg Gln Ser Ser Val Ser Phe Arg Ser Gly Gly Ser Arg Ser 
1               5                   10                  15      


Phe Ser Thr Ala Ser Ala Ile Thr Pro Ser Val Ser Arg Thr Ser Phe 
            20                  25                  30          


Thr Ser Val Ser Arg Ser Gly Gly Gly Gly Gly Gly Gly Phe Gly Arg 
        35                  40                  45              


Val Ser Leu Ala Gly Ala Cys Gly Val Gly Gly Tyr Gly Ser Arg Ser 
    50                  55                  60                  


Leu Tyr Asn Leu Gly Gly Ser Lys Arg Ile Ser Ile Ser Thr Arg Gly 
65                  70                  75                  80  


Gly Ser Phe Arg Asn Arg Phe Gly Ala Gly Ala Gly Gly Gly Tyr Gly 
                85                  90                  95      


Phe Gly Gly Gly Ala Gly Ser Gly Phe Gly Phe Gly Gly Gly Ala Gly 
            100                 105                 110         


Gly Gly Phe Gly Leu Gly Gly Gly Ala Gly Phe Gly Gly Gly Phe Gly 
        115                 120                 125             


Gly Pro Gly Phe Pro Val Cys Pro Pro Gly Gly Ile Gln Glu Val Thr 
    130                 135                 140                 


Val Asn Gln Ser Leu Leu Thr Pro Leu Asn Leu Gln Ile Asp Pro Ser 
145                 150                 155                 160 


Ile Gln Arg Val Arg Thr Glu Glu Arg Glu Gln Ile Lys Thr Leu Asn 
                165                 170                 175     


Asn Lys Phe Ala Ser Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln 
            180                 185                 190         


Asn Lys Val Leu Asp Thr Lys Trp Thr Leu Leu Gln Glu Gln Gly Thr 
        195                 200                 205             


Lys Thr Val Arg Gln Asn Leu Glu Pro Leu Phe Glu Gln Tyr Ile Asn 
    210                 215                 220                 


Asn Leu Arg Arg Gln Leu Asp Ser Ile Val Gly Glu Arg Gly Arg Leu 
225                 230                 235                 240 


Asp Ser Glu Leu Arg Asn Met Gln Asp Leu Val Glu Asp Phe Lys Asn 
                245                 250                 255     


Lys Tyr Glu Asp Glu Ile Asn Lys Arg Thr Thr Ala Glu Asn Glu Phe 
            260                 265                 270         


Val Met Leu Lys Lys Asp Val Asp Ala Ala Tyr Met Asn Lys Val Glu 
        275                 280                 285             


Leu Glu Ala Lys Val Asp Ala Leu Met Asp Glu Ile Asn Phe Met Lys 
    290                 295                 300                 


Met Phe Phe Asp Ala Glu Leu Ser Gln Met Gln Thr His Val Ser Asp 
305                 310                 315                 320 


Thr Ser Val Val Leu Ser Met Asp Asn Asn Arg Asn Leu Asp Leu Asp 
                325                 330                 335     


Ser Ile Ile Ala Glu Val Lys Ala Gln Tyr Glu Glu Ile Ala Asn Arg 
            340                 345                 350         


Ser Arg Thr Glu Ala Glu Ser Trp Tyr Gln Thr Lys Tyr Glu Glu Leu 
        355                 360                 365             


Gln Gln Thr Ala Gly Arg His Gly Asp Asp Leu Arg Asn Thr Lys His 
    370                 375                 380                 


Glu Ile Thr Glu Met Asn Arg Met Ile Gln Arg Leu Arg Ala Glu Ile 
385                 390                 395                 400 


Asp Asn Val Lys Lys Gln Cys Ala Asn Leu Gln Asn Ala Ile Ala Asp 
                405                 410                 415     


Ala Glu Gln Arg Gly Glu Leu Ala Leu Lys Asp Ala Arg Asn Lys Leu 
            420                 425                 430         


Ala Glu Leu Glu Glu Ala Leu Gln Lys Ala Lys Gln Asp Met Ala Arg 
        435                 440                 445             


Leu Leu Arg Glu Tyr Gln Glu Leu Met Asn Thr Lys Leu Ala Leu Asp 
    450                 455                 460                 


Val Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg 
465                 470                 475                 480 


Leu Ser Gly Glu Gly Val Gly Pro Val Asn Ile Ser Val Val Thr Ser 
                485                 490                 495     


Ser Val Ser Ser Gly Tyr Gly Ser Gly Ser Gly Tyr Gly Gly Gly Leu 
            500                 505                 510         


Gly Gly Gly Leu Gly Gly Gly Leu Gly Gly Gly Leu Ala Gly Gly Ser 
        515                 520                 525             


Ser Gly Ser Tyr Tyr Ser Ser Ser Ser Gly Gly Val Gly Leu Gly Gly 
    530                 535                 540                 


Gly Leu Ser Val Gly Gly Ser Gly Phe Ser Ala Ser Ser Gly Arg Gly 
545                 550                 555                 560 


Leu Gly Val Gly Phe Gly Ser Gly Gly Gly Ser Ser Ser Ser Val Lys 
                565                 570                 575     


Phe Val Ser Thr Thr Ser Ser Ser Arg Lys Ser Phe Lys Ser 
            580                 585                 590 


<210> 3
<211> 472
<212> PRT
<213> Homo sapiens

<400> 3
Met Thr Thr Cys Ser Arg Gln Phe Thr Ser Ser Ser Ser Met Lys Gly 
1               5                   10                  15      


Ser Cys Gly Ile Gly Gly Gly Ile Gly Gly Gly Ser Ser Arg Ile Ser 
            20                  25                  30          


Ser Val Leu Ala Gly Gly Ser Cys Arg Ala Pro Ser Thr Tyr Gly Gly 
        35                  40                  45              


Gly Leu Ser Val Ser Ser Ser Arg Phe Ser Ser Gly Gly Ala Tyr Gly 
    50                  55                  60                  


Leu Gly Gly Gly Tyr Gly Gly Gly Phe Ser Ser Ser Ser Ser Ser Phe 
65                  70                  75                  80  


Gly Ser Gly Phe Gly Gly Gly Tyr Gly Gly Gly Leu Gly Thr Gly Leu 
                85                  90                  95      


Gly Gly Gly Phe Gly Gly Gly Phe Ala Gly Gly Asp Gly Leu Leu Val 
            100                 105                 110         


Gly Ser Glu Lys Val Thr Met Gln Asn Leu Asn Asp Arg Leu Ala Ser 
        115                 120                 125             


Tyr Leu Asp Lys Val Arg Ala Leu Glu Glu Ala Asn Ala Asp Leu Glu 
    130                 135                 140                 


Val Lys Ile Arg Asp Trp Tyr Gln Arg Gln Arg Pro Ala Glu Ile Lys 
145                 150                 155                 160 


Asp Tyr Ser Pro Tyr Phe Lys Thr Ile Glu Asp Leu Arg Asn Lys Ile 
                165                 170                 175     


Leu Thr Ala Thr Val Asp Asn Ala Asn Val Leu Leu Gln Ile Asp Asn 
            180                 185                 190         


Ala Arg Leu Ala Ala Asp Asp Phe Arg Thr Lys Tyr Glu Thr Glu Leu 
        195                 200                 205             


Asn Leu Arg Met Ser Val Glu Ala Asp Ile Asn Gly Leu Arg Arg Val 
    210                 215                 220                 


Leu Asp Glu Leu Thr Leu Ala Arg Ala Asp Leu Glu Met Gln Ile Glu 
225                 230                 235                 240 


Ser Leu Lys Glu Glu Leu Ala Tyr Leu Lys Lys Asn His Glu Glu Glu 
                245                 250                 255     


Met Asn Ala Leu Arg Gly Gln Val Gly Gly Asp Val Asn Val Glu Met 
            260                 265                 270         


Asp Ala Ala Pro Gly Val Asp Leu Ser Arg Ile Leu Asn Glu Met Arg 
        275                 280                 285             


Asp Gln Tyr Glu Lys Met Ala Glu Lys Asn Arg Lys Asp Ala Glu Glu 
    290                 295                 300                 


Trp Phe Phe Thr Lys Thr Glu Glu Leu Asn Arg Glu Val Ala Thr Asn 
305                 310                 315                 320 


Ser Glu Leu Val Gln Ser Gly Lys Ser Glu Ile Ser Glu Leu Arg Arg 
                325                 330                 335     


Thr Met Gln Asn Leu Glu Ile Glu Leu Gln Ser Gln Leu Ser Met Lys 
            340                 345                 350         


Ala Ser Leu Glu Asn Ser Leu Glu Glu Thr Lys Gly Arg Tyr Cys Met 
        355                 360                 365             


Gln Leu Ala Gln Ile Gln Glu Met Ile Gly Ser Val Glu Glu Gln Leu 
    370                 375                 380                 


Ala Gln Leu Arg Cys Glu Met Glu Gln Gln Asn Gln Glu Tyr Lys Ile 
385                 390                 395                 400 


Leu Leu Asp Val Lys Thr Arg Leu Glu Gln Glu Ile Ala Thr Tyr Arg 
                405                 410                 415     


Arg Leu Leu Glu Gly Glu Asp Ala His Leu Ser Ser Ser Gln Phe Ser 
            420                 425                 430         


Ser Gly Ser Gln Ser Ser Arg Asp Val Thr Ser Ser Ser Arg Gln Ile 
        435                 440                 445             


Arg Thr Lys Val Met Asp Val His Asp Gly Lys Val Val Ser Thr His 
    450                 455                 460                 


Glu Gln Val Leu Arg Thr Lys Asn 
465                 470         


<210> 4
<211> 644
<212> PRT
<213> Homo sapiens

<400> 4
Met Phe Ser Met Arg Ile Val Cys Leu Val Leu Ser Val Val Gly Thr 
1               5                   10                  15      


Ala Trp Thr Ala Asp Ser Gly Glu Gly Asp Phe Leu Ala Glu Gly Gly 
            20                  25                  30          


Gly Val Arg Gly Pro Arg Val Val Glu Arg His Gln Ser Ala Cys Lys 
        35                  40                  45              


Asp Ser Asp Trp Pro Phe Cys Ser Asp Glu Asp Trp Asn Tyr Lys Cys 
    50                  55                  60                  


Pro Ser Gly Cys Arg Met Lys Gly Leu Ile Asp Glu Val Asn Gln Asp 
65                  70                  75                  80  


Phe Thr Asn Arg Ile Asn Lys Leu Lys Asn Ser Leu Phe Glu Tyr Gln 
                85                  90                  95      


Lys Asn Asn Lys Asp Ser His Ser Leu Thr Thr Asn Ile Met Glu Ile 
            100                 105                 110         


Leu Arg Gly Asp Phe Ser Ser Ala Asn Asn Arg Asp Asn Thr Tyr Asn 
        115                 120                 125             


Arg Val Ser Glu Asp Leu Arg Ser Arg Ile Glu Val Leu Lys Arg Lys 
    130                 135                 140                 


Val Ile Glu Lys Val Gln His Ile Gln Leu Leu Gln Lys Asn Val Arg 
145                 150                 155                 160 


Ala Gln Leu Val Asp Met Lys Arg Leu Glu Val Asp Ile Asp Ile Lys 
                165                 170                 175     


Ile Arg Ser Cys Arg Gly Ser Cys Ser Arg Ala Leu Ala Arg Glu Val 
            180                 185                 190         


Asp Leu Lys Asp Tyr Glu Asp Gln Gln Lys Gln Leu Glu Gln Val Ile 
        195                 200                 205             


Ala Lys Asp Leu Leu Pro Ser Arg Asp Arg Gln His Leu Pro Leu Ile 
    210                 215                 220                 


Lys Met Lys Pro Val Pro Asp Leu Val Pro Gly Asn Phe Lys Ser Gln 
225                 230                 235                 240 


Leu Gln Lys Val Pro Pro Glu Trp Lys Ala Leu Thr Asp Met Pro Gln 
                245                 250                 255     


Met Arg Met Glu Leu Glu Arg Pro Gly Gly Asn Glu Ile Thr Arg Gly 
            260                 265                 270         


Gly Ser Thr Ser Tyr Gly Thr Gly Ser Glu Thr Glu Ser Pro Arg Asn 
        275                 280                 285             


Pro Ser Ser Ala Gly Ser Trp Asn Ser Gly Ser Ser Gly Pro Gly Ser 
    290                 295                 300                 


Thr Gly Asn Arg Asn Pro Gly Ser Ser Gly Thr Gly Gly Thr Ala Thr 
305                 310                 315                 320 


Trp Lys Pro Gly Ser Ser Gly Pro Gly Ser Thr Gly Ser Trp Asn Ser 
                325                 330                 335     


Gly Ser Ser Gly Thr Gly Ser Thr Gly Asn Gln Asn Pro Gly Ser Pro 
            340                 345                 350         


Arg Pro Gly Ser Thr Gly Thr Trp Asn Pro Gly Ser Ser Glu Arg Gly 
        355                 360                 365             


Ser Ala Gly His Trp Thr Ser Glu Ser Ser Val Ser Gly Ser Thr Gly 
    370                 375                 380                 


Gln Trp His Ser Glu Ser Gly Ser Phe Arg Pro Asp Ser Pro Gly Ser 
385                 390                 395                 400 


Gly Asn Ala Arg Pro Asn Asn Pro Asp Trp Gly Thr Phe Glu Glu Val 
                405                 410                 415     


Ser Gly Asn Val Ser Pro Gly Thr Arg Arg Glu Tyr His Thr Glu Lys 
            420                 425                 430         


Leu Val Thr Ser Lys Gly Asp Lys Glu Leu Arg Thr Gly Lys Glu Lys 
        435                 440                 445             


Val Thr Ser Gly Ser Thr Thr Thr Thr Arg Arg Ser Cys Ser Lys Thr 
    450                 455                 460                 


Val Thr Lys Thr Val Ile Gly Pro Asp Gly His Lys Glu Val Thr Lys 
465                 470                 475                 480 


Glu Val Val Thr Ser Glu Asp Gly Ser Asp Cys Pro Glu Ala Met Asp 
                485                 490                 495     


Leu Gly Thr Leu Ser Gly Ile Gly Thr Leu Asp Gly Phe Arg His Arg 
            500                 505                 510         


His Pro Asp Glu Ala Ala Phe Phe Asp Thr Ala Ser Thr Gly Lys Thr 
        515                 520                 525             


Phe Pro Gly Phe Phe Ser Pro Met Leu Gly Glu Phe Val Ser Glu Thr 
    530                 535                 540                 


Glu Ser Arg Gly Ser Glu Ser Gly Ile Phe Thr Asn Thr Lys Glu Ser 
545                 550                 555                 560 


Ser Ser His His Pro Gly Ile Ala Glu Phe Pro Ser Arg Gly Lys Ser 
                565                 570                 575     


Ser Ser Tyr Ser Lys Gln Phe Thr Ser Ser Thr Ser Tyr Asn Arg Gly 
            580                 585                 590         


Asp Ser Thr Phe Glu Ser Lys Ser Tyr Lys Met Ala Asp Glu Ala Gly 
        595                 600                 605             


Ser Glu Ala Asp His Glu Gly Thr His Ser Thr Lys Arg Gly His Ala 
    610                 615                 620                 


Lys Ser Arg Pro Val Arg Gly Ile His Thr Ser Pro Leu Gly Lys Pro 
625                 630                 635                 640 


Ser Leu Ser Pro 
                


<210> 5
<211> 491
<212> PRT
<213> Homo sapiens

<400> 5
Met Lys Arg Met Val Ser Trp Ser Phe His Lys Leu Lys Thr Met Lys 
1               5                   10                  15      


His Leu Leu Leu Leu Leu Leu Cys Val Phe Leu Val Lys Ser Gln Gly 
            20                  25                  30          


Val Asn Asp Asn Glu Glu Gly Phe Phe Ser Ala Arg Gly His Arg Pro 
        35                  40                  45              


Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser Leu Arg Pro Ala Pro Pro 
    50                  55                  60                  


Pro Ile Ser Gly Gly Gly Tyr Arg Ala Arg Pro Ala Lys Ala Ala Ala 
65                  70                  75                  80  


Thr Gln Lys Lys Val Glu Arg Lys Ala Pro Asp Ala Gly Gly Cys Leu 
                85                  90                  95      


His Ala Asp Pro Asp Leu Gly Val Leu Cys Pro Thr Gly Cys Gln Leu 
            100                 105                 110         


Gln Glu Ala Leu Leu Gln Gln Glu Arg Pro Ile Arg Asn Ser Val Asp 
        115                 120                 125             


Glu Leu Asn Asn Asn Val Glu Ala Val Ser Gln Thr Ser Ser Ser Ser 
    130                 135                 140                 


Phe Gln Tyr Met Tyr Leu Leu Lys Asp Leu Trp Gln Lys Arg Gln Lys 
145                 150                 155                 160 


Gln Val Lys Asp Asn Glu Asn Val Val Asn Glu Tyr Ser Ser Glu Leu 
                165                 170                 175     


Glu Lys His Gln Leu Tyr Ile Asp Glu Thr Val Asn Ser Asn Ile Pro 
            180                 185                 190         


Thr Asn Leu Arg Val Leu Arg Ser Ile Leu Glu Asn Leu Arg Ser Lys 
        195                 200                 205             


Ile Gln Lys Leu Glu Ser Asp Val Ser Ala Gln Met Glu Tyr Cys Arg 
    210                 215                 220                 


Thr Pro Cys Thr Val Ser Cys Asn Ile Pro Val Val Ser Gly Lys Glu 
225                 230                 235                 240 


Cys Glu Glu Ile Ile Arg Lys Gly Gly Glu Thr Ser Glu Met Tyr Leu 
                245                 250                 255     


Ile Gln Pro Asp Ser Ser Val Lys Pro Tyr Arg Val Tyr Cys Asp Met 
            260                 265                 270         


Asn Thr Glu Asn Gly Gly Trp Thr Val Ile Gln Asn Arg Gln Asp Gly 
        275                 280                 285             


Ser Val Asp Phe Gly Arg Lys Trp Asp Pro Tyr Lys Gln Gly Phe Gly 
    290                 295                 300                 


Asn Val Ala Thr Asn Thr Asp Gly Lys Asn Tyr Cys Gly Leu Pro Gly 
305                 310                 315                 320 


Glu Tyr Trp Leu Gly Asn Asp Lys Ile Ser Gln Leu Thr Arg Met Gly 
                325                 330                 335     


Pro Thr Glu Leu Leu Ile Glu Met Glu Asp Trp Lys Gly Asp Lys Val 
            340                 345                 350         


Lys Ala His Tyr Gly Gly Phe Thr Val Gln Asn Glu Ala Asn Lys Tyr 
        355                 360                 365             


Gln Ile Ser Val Asn Lys Tyr Arg Gly Thr Ala Gly Asn Ala Leu Met 
    370                 375                 380                 


Asp Gly Ala Ser Gln Leu Met Gly Glu Asn Arg Thr Met Thr Ile His 
385                 390                 395                 400 


Asn Gly Met Phe Phe Ser Thr Tyr Asp Arg Asp Asn Asp Gly Trp Leu 
                405                 410                 415     


Thr Ser Asp Pro Arg Lys Gln Cys Ser Lys Glu Asp Gly Gly Gly Trp 
            420                 425                 430         


Trp Tyr Asn Arg Cys His Ala Ala Asn Pro Asn Gly Arg Tyr Tyr Trp 
        435                 440                 445             


Gly Gly Gln Tyr Thr Trp Asp Met Ala Lys His Gly Thr Asp Asp Gly 
    450                 455                 460                 


Val Val Trp Met Asn Trp Lys Gly Ser Trp Tyr Ser Met Arg Lys Met 
465                 470                 475                 480 


Ser Met Lys Ile Arg Pro Phe Phe Pro Gln Gln 
                485                 490     


<210> 6
<211> 437
<212> PRT
<213> Homo sapiens

<400> 6
Met Ser Trp Ser Leu His Pro Arg Asn Leu Ile Leu Tyr Phe Tyr Ala 
1               5                   10                  15      


Leu Leu Phe Leu Ser Ser Thr Cys Val Ala Tyr Val Ala Thr Arg Asp 
            20                  25                  30          


Asn Cys Cys Ile Leu Asp Glu Arg Phe Gly Ser Tyr Cys Pro Thr Thr 
        35                  40                  45              


Cys Gly Ile Ala Asp Phe Leu Ser Thr Tyr Gln Thr Lys Val Asp Lys 
    50                  55                  60                  


Asp Leu Gln Ser Leu Glu Asp Ile Leu His Gln Val Glu Asn Lys Thr 
65                  70                  75                  80  


Ser Glu Val Lys Gln Leu Ile Lys Ala Ile Gln Leu Thr Tyr Asn Pro 
                85                  90                  95      


Asp Glu Ser Ser Lys Pro Asn Met Ile Asp Ala Ala Thr Leu Lys Ser 
            100                 105                 110         


Arg Ile Met Leu Glu Glu Ile Met Lys Tyr Glu Ala Ser Ile Leu Thr 
        115                 120                 125             


His Asp Ser Ser Ile Arg Tyr Leu Gln Glu Ile Tyr Asn Ser Asn Asn 
    130                 135                 140                 


Gln Lys Ile Val Asn Leu Lys Glu Lys Val Ala Gln Leu Glu Ala Gln 
145                 150                 155                 160 


Cys Gln Glu Pro Cys Lys Asp Thr Val Gln Ile His Asp Ile Thr Gly 
                165                 170                 175     


Lys Asp Cys Gln Asp Ile Ala Asn Lys Gly Ala Lys Gln Ser Gly Leu 
            180                 185                 190         


Tyr Phe Ile Lys Pro Leu Lys Ala Asn Gln Gln Phe Leu Val Tyr Cys 
        195                 200                 205             


Glu Ile Asp Gly Ser Gly Asn Gly Trp Thr Val Phe Gln Lys Arg Leu 
    210                 215                 220                 


Asp Gly Ser Val Asp Phe Lys Lys Asn Trp Ile Gln Tyr Lys Glu Gly 
225                 230                 235                 240 


Phe Gly His Leu Ser Pro Thr Gly Thr Thr Glu Phe Trp Leu Gly Asn 
                245                 250                 255     


Glu Lys Ile His Leu Ile Ser Thr Gln Ser Ala Ile Pro Tyr Ala Leu 
            260                 265                 270         


Arg Val Glu Leu Glu Asp Trp Asn Gly Arg Thr Ser Thr Ala Asp Tyr 
        275                 280                 285             


Ala Met Phe Lys Val Gly Pro Glu Ala Asp Lys Tyr Arg Leu Thr Tyr 
    290                 295                 300                 


Ala Tyr Phe Ala Gly Gly Asp Ala Gly Asp Ala Phe Asp Gly Phe Asp 
305                 310                 315                 320 


Phe Gly Asp Asp Pro Ser Asp Lys Phe Phe Thr Ser His Asn Gly Met 
                325                 330                 335     


Gln Phe Ser Thr Trp Asp Asn Asp Asn Asp Lys Phe Glu Gly Asn Cys 
            340                 345                 350         


Ala Glu Gln Asp Gly Ser Gly Trp Trp Met Asn Lys Cys His Ala Gly 
        355                 360                 365             


His Leu Asn Gly Val Tyr Tyr Gln Gly Gly Thr Tyr Ser Lys Ala Ser 
    370                 375                 380                 


Thr Pro Asn Gly Tyr Asp Asn Gly Ile Ile Trp Ala Thr Trp Lys Thr 
385                 390                 395                 400 


Arg Trp Tyr Ser Met Lys Lys Thr Thr Met Lys Ile Ile Pro Phe Asn 
                405                 410                 415     


Arg Leu Thr Ile Gly Glu Gly Gln Gln His His Leu Gly Gly Ala Lys 
            420                 425                 430         


Gln Ala Gly Asp Val 
        435         


<210> 7
<211> 757
<212> PRT
<213> Homo sapiens

<400> 7
Met Ala Gly Leu Thr Ala Ala Ala Pro Arg Pro Gly Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ile Leu His Pro Ser Arg Pro Gly Gly Val Pro Gly Ala 
            20                  25                  30          


Ile Pro Gly Gly Val Pro Gly Gly Val Phe Tyr Pro Gly Ala Gly Leu 
        35                  40                  45              


Gly Ala Leu Gly Gly Gly Ala Leu Gly Pro Gly Gly Lys Pro Leu Lys 
    50                  55                  60                  


Pro Val Pro Gly Gly Leu Ala Gly Ala Gly Leu Gly Ala Gly Leu Gly 
65                  70                  75                  80  


Ala Phe Pro Ala Val Thr Phe Pro Gly Ala Leu Val Pro Gly Gly Val 
                85                  90                  95      


Ala Asp Ala Ala Ala Ala Tyr Lys Ala Ala Lys Ala Gly Ala Gly Leu 
            100                 105                 110         


Gly Gly Val Pro Gly Val Gly Gly Leu Gly Val Ser Ala Gly Ala Val 
        115                 120                 125             


Val Pro Gln Pro Gly Ala Gly Val Lys Pro Gly Lys Val Pro Gly Val 
    130                 135                 140                 


Gly Leu Pro Gly Val Tyr Pro Gly Gly Val Leu Pro Gly Ala Arg Phe 
145                 150                 155                 160 


Pro Gly Val Gly Val Leu Pro Gly Val Pro Thr Gly Ala Gly Val Lys 
                165                 170                 175     


Pro Lys Ala Pro Gly Val Gly Gly Ala Phe Ala Gly Ile Pro Gly Val 
            180                 185                 190         


Gly Pro Phe Gly Gly Pro Gln Pro Gly Val Pro Leu Gly Tyr Pro Ile 
        195                 200                 205             


Lys Ala Pro Lys Leu Pro Gly Gly Tyr Gly Leu Pro Tyr Thr Thr Gly 
    210                 215                 220                 


Lys Leu Pro Tyr Gly Tyr Gly Pro Gly Gly Val Ala Gly Ala Ala Gly 
225                 230                 235                 240 


Lys Ala Gly Tyr Pro Thr Gly Thr Gly Val Gly Pro Gln Ala Ala Ala 
                245                 250                 255     


Ala Ala Ala Ala Lys Ala Ala Ala Lys Phe Gly Ala Gly Ala Ala Gly 
            260                 265                 270         


Val Leu Pro Gly Val Gly Gly Ala Gly Val Pro Gly Val Pro Gly Ala 
        275                 280                 285             


Ile Pro Gly Ile Gly Gly Ile Ala Gly Val Gly Thr Pro Ala Ala Ala 
    290                 295                 300                 


Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Lys Tyr Gly Ala Ala Ala 
305                 310                 315                 320 


Gly Leu Val Pro Gly Gly Pro Gly Phe Gly Pro Gly Val Val Gly Val 
                325                 330                 335     


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Ala Gly Ile Pro 
            340                 345                 350         


Val Val Pro Gly Ala Gly Ile Pro Gly Ala Ala Val Pro Gly Val Val 
        355                 360                 365             


Ser Pro Glu Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Lys Tyr Gly 
    370                 375                 380                 


Ala Arg Pro Gly Val Gly Val Gly Gly Ile Pro Thr Tyr Gly Val Gly 
385                 390                 395                 400 


Ala Gly Gly Phe Pro Gly Phe Gly Val Gly Val Gly Gly Ile Pro Gly 
                405                 410                 415     


Val Ala Gly Val Pro Ser Val Gly Gly Val Pro Gly Val Gly Gly Val 
            420                 425                 430         


Pro Gly Val Gly Ile Ser Pro Glu Ala Gln Ala Ala Ala Ala Ala Lys 
        435                 440                 445             


Ala Ala Lys Tyr Gly Val Gly Thr Pro Ala Ala Ala Ala Ala Lys Ala 
    450                 455                 460                 


Ala Ala Lys Ala Ala Gln Phe Gly Leu Val Pro Gly Val Gly Val Ala 
465                 470                 475                 480 


Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly 
                485                 490                 495     


Leu Ala Pro Gly Val Gly Val Ala Pro Gly Val Gly Val Ala Pro Gly 
            500                 505                 510         


Val Gly Val Ala Pro Gly Ile Gly Pro Gly Gly Val Ala Ala Ala Ala 
        515                 520                 525             


Lys Ser Ala Ala Lys Val Ala Ala Lys Ala Gln Leu Arg Ala Ala Ala 
    530                 535                 540                 


Gly Leu Gly Ala Gly Ile Pro Gly Leu Gly Val Gly Val Gly Val Pro 
545                 550                 555                 560 


Gly Leu Gly Val Gly Ala Gly Val Pro Gly Leu Gly Val Gly Ala Gly 
                565                 570                 575     


Val Pro Gly Phe Gly Ala Gly Ala Asp Glu Gly Val Arg Arg Ser Leu 
            580                 585                 590         


Ser Pro Glu Leu Arg Glu Gly Asp Pro Ser Ser Ser Gln His Leu Pro 
        595                 600                 605             


Ser Thr Pro Ser Ser Pro Arg Val Pro Gly Ala Leu Ala Ala Ala Lys 
    610                 615                 620                 


Ala Ala Lys Tyr Gly Ala Ala Val Pro Gly Val Leu Gly Gly Leu Gly 
625                 630                 635                 640 


Ala Leu Gly Gly Val Gly Ile Pro Gly Gly Val Val Gly Ala Gly Pro 
                645                 650                 655     


Ala Ala Ala Ala Ala Ala Ala Lys Ala Ala Ala Lys Ala Ala Gln Phe 
            660                 665                 670         


Gly Leu Val Gly Ala Ala Gly Leu Gly Gly Leu Gly Val Gly Gly Leu 
        675                 680                 685             


Gly Val Pro Gly Val Gly Gly Leu Gly Gly Ile Pro Pro Ala Ala Ala 
    690                 695                 700                 


Ala Lys Ala Ala Lys Tyr Gly Ala Ala Gly Leu Gly Gly Val Leu Gly 
705                 710                 715                 720 


Gly Ala Gly Gln Phe Pro Leu Gly Gly Val Ala Ala Arg Pro Gly Phe 
                725                 730                 735     


Gly Leu Ser Pro Ile Phe Pro Gly Gly Ala Cys Leu Gly Lys Ala Cys 
            740                 745                 750         


Gly Arg Lys Arg Lys 
        755         


<210> 8
<211> 1678
<212> PRT
<213> Homo sapiens

<400> 8
Met His Pro Gly Leu Trp Leu Leu Leu Val Thr Leu Cys Leu Thr Glu 
1               5                   10                  15      


Glu Leu Ala Ala Ala Gly Glu Lys Ser Tyr Gly Lys Pro Cys Gly Gly 
            20                  25                  30          


Gln Asp Cys Ser Gly Ser Cys Gln Cys Phe Pro Glu Lys Gly Ala Arg 
        35                  40                  45              


Gly Arg Pro Gly Pro Ile Gly Ile Gln Gly Pro Thr Gly Pro Gln Gly 
    50                  55                  60                  


Phe Thr Gly Ser Thr Gly Leu Ser Gly Leu Lys Gly Glu Arg Gly Phe 
65                  70                  75                  80  


Pro Gly Leu Leu Gly Pro Tyr Gly Pro Lys Gly Asp Lys Gly Pro Met 
                85                  90                  95      


Gly Val Pro Gly Phe Leu Gly Ile Asn Gly Ile Pro Gly His Pro Gly 
            100                 105                 110         


Gln Pro Gly Pro Arg Gly Pro Pro Gly Leu Asp Gly Cys Asn Gly Thr 
        115                 120                 125             


Gln Gly Ala Val Gly Phe Pro Gly Pro Asp Gly Tyr Pro Gly Leu Leu 
    130                 135                 140                 


Gly Pro Pro Gly Leu Pro Gly Gln Lys Gly Ser Lys Gly Asp Pro Val 
145                 150                 155                 160 


Leu Ala Pro Gly Ser Phe Lys Gly Met Lys Gly Asp Pro Gly Leu Pro 
                165                 170                 175     


Gly Leu Asp Gly Ile Thr Gly Pro Gln Gly Ala Pro Gly Phe Pro Gly 
            180                 185                 190         


Ala Val Gly Pro Ala Gly Pro Pro Gly Leu Gln Gly Pro Pro Gly Pro 
        195                 200                 205             


Pro Gly Pro Leu Gly Pro Asp Gly Asn Met Gly Leu Gly Phe Gln Gly 
    210                 215                 220                 


Glu Lys Gly Val Lys Gly Asp Val Gly Leu Pro Gly Pro Ala Gly Pro 
225                 230                 235                 240 


Pro Pro Ser Thr Gly Glu Leu Glu Phe Met Gly Phe Pro Lys Gly Lys 
                245                 250                 255     


Lys Gly Ser Lys Gly Glu Pro Gly Pro Lys Gly Phe Pro Gly Ile Ser 
            260                 265                 270         


Gly Pro Pro Gly Phe Pro Gly Leu Gly Thr Thr Gly Glu Lys Gly Glu 
        275                 280                 285             


Lys Gly Glu Lys Gly Ile Pro Gly Leu Pro Gly Pro Arg Gly Pro Met 
    290                 295                 300                 


Gly Ser Glu Gly Val Gln Gly Pro Pro Gly Gln Gln Gly Lys Lys Gly 
305                 310                 315                 320 


Thr Leu Gly Phe Pro Gly Leu Asn Gly Phe Gln Gly Ile Glu Gly Gln 
                325                 330                 335     


Lys Gly Asp Ile Gly Leu Pro Gly Pro Asp Val Phe Ile Asp Ile Asp 
            340                 345                 350         


Gly Ala Val Ile Ser Gly Asn Pro Gly Asp Pro Gly Val Pro Gly Leu 
        355                 360                 365             


Pro Gly Leu Lys Gly Asp Glu Gly Ile Gln Gly Leu Arg Gly Pro Ser 
    370                 375                 380                 


Gly Val Pro Gly Leu Pro Ala Leu Ser Gly Val Pro Gly Ala Leu Gly 
385                 390                 395                 400 


Pro Gln Gly Phe Pro Gly Leu Lys Gly Asp Gln Gly Asn Pro Gly Arg 
                405                 410                 415     


Thr Thr Ile Gly Ala Ala Gly Leu Pro Gly Arg Asp Gly Leu Pro Gly 
            420                 425                 430         


Pro Pro Gly Pro Pro Gly Pro Pro Ser Pro Glu Phe Glu Thr Glu Thr 
        435                 440                 445             


Leu His Asn Lys Glu Ser Gly Phe Pro Gly Leu Arg Gly Glu Gln Gly 
    450                 455                 460                 


Pro Lys Gly Asn Leu Gly Leu Lys Gly Ile Lys Gly Asp Ser Gly Phe 
465                 470                 475                 480 


Cys Ala Cys Asp Gly Gly Val Pro Asn Thr Gly Pro Pro Gly Glu Pro 
                485                 490                 495     


Gly Pro Pro Gly Pro Trp Gly Leu Ile Gly Leu Pro Gly Leu Lys Gly 
            500                 505                 510         


Ala Arg Gly Asp Arg Gly Ser Gly Gly Ala Gln Gly Pro Ala Gly Ala 
        515                 520                 525             


Pro Gly Leu Val Gly Pro Leu Gly Pro Ser Gly Pro Lys Gly Lys Lys 
    530                 535                 540                 


Gly Glu Pro Ile Leu Ser Thr Ile Gln Gly Met Pro Gly Asp Arg Gly 
545                 550                 555                 560 


Asp Ser Gly Ser Gln Gly Phe Arg Gly Val Ile Gly Glu Pro Gly Lys 
                565                 570                 575     


Asp Gly Val Pro Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Asp Gly 
            580                 585                 590         


Gly Gln Gly Phe Pro Gly Glu Lys Gly Leu Pro Gly Leu Pro Gly Glu 
        595                 600                 605             


Lys Gly His Pro Gly Pro Pro Gly Leu Pro Gly Asn Gly Leu Pro Gly 
    610                 615                 620                 


Leu Pro Gly Pro Arg Gly Leu Pro Gly Asp Lys Gly Lys Asp Gly Leu 
625                 630                 635                 640 


Pro Gly Gln Gln Gly Leu Pro Gly Ser Lys Gly Ile Thr Leu Pro Cys 
                645                 650                 655     


Ile Ile Pro Gly Ser Tyr Gly Pro Ser Gly Phe Pro Gly Thr Pro Gly 
            660                 665                 670         


Phe Pro Gly Pro Lys Gly Ser Arg Gly Leu Pro Gly Thr Pro Gly Gln 
        675                 680                 685             


Pro Gly Ser Ser Gly Ser Lys Gly Glu Pro Gly Ser Pro Gly Leu Val 
    690                 695                 700                 


His Leu Pro Glu Leu Pro Gly Phe Pro Gly Pro Arg Gly Glu Lys Gly 
705                 710                 715                 720 


Leu Pro Gly Phe Pro Gly Leu Pro Gly Lys Asp Gly Leu Pro Gly Met 
                725                 730                 735     


Ile Gly Ser Pro Gly Leu Pro Gly Ser Lys Gly Ala Thr Gly Asp Ile 
            740                 745                 750         


Phe Gly Ala Glu Asn Gly Ala Pro Gly Glu Gln Gly Leu Gln Gly Leu 
        755                 760                 765             


Thr Gly His Lys Gly Phe Leu Gly Asp Ser Gly Leu Pro Gly Leu Lys 
    770                 775                 780                 


Gly Val His Gly Lys Pro Gly Leu Leu Gly Pro Lys Gly Glu Arg Gly 
785                 790                 795                 800 


Ser Pro Gly Thr Pro Gly Gln Val Gly Gln Pro Gly Thr Pro Gly Ser 
                805                 810                 815     


Ser Gly Pro Tyr Gly Ile Lys Gly Lys Ser Gly Leu Pro Gly Ala Pro 
            820                 825                 830         


Gly Phe Pro Gly Ile Ser Gly His Pro Gly Lys Lys Gly Thr Arg Gly 
        835                 840                 845             


Lys Lys Gly Pro Pro Gly Ser Ile Val Lys Lys Gly Leu Pro Gly Leu 
    850                 855                 860                 


Lys Gly Leu Pro Gly Asn Pro Gly Leu Val Gly Leu Lys Gly Ser Pro 
865                 870                 875                 880 


Gly Ser Pro Gly Val Ala Gly Leu Pro Ala Leu Ser Gly Pro Lys Gly 
                885                 890                 895     


Glu Lys Gly Ser Val Gly Phe Val Gly Phe Pro Gly Ile Pro Gly Leu 
            900                 905                 910         


Pro Gly Ile Ser Gly Thr Arg Gly Leu Lys Gly Ile Pro Gly Ser Thr 
        915                 920                 925             


Gly Lys Met Gly Pro Ser Gly Arg Ala Gly Thr Pro Gly Glu Lys Gly 
    930                 935                 940                 


Asp Arg Gly Asn Pro Gly Pro Val Gly Ile Pro Ser Pro Arg Arg Pro 
945                 950                 955                 960 


Met Ser Asn Leu Trp Leu Lys Gly Asp Lys Gly Ser Gln Gly Ser Ala 
                965                 970                 975     


Gly Ser Asn Gly Phe Pro Gly Pro Arg Gly Asp Lys Gly Glu Ala Gly 
            980                 985                 990         


Arg Pro Gly Pro Pro Gly Leu Pro  Gly Ala Pro Gly Leu  Pro Gly Ile 
        995                 1000                 1005             


Ile Lys  Gly Val Ser Gly Lys  Pro Gly Pro Pro Gly  Phe Met Gly 
    1010                 1015                 1020             


Ile Arg  Gly Leu Pro Gly Leu  Lys Gly Ser Ser Gly  Ile Thr Gly 
    1025                 1030                 1035             


Phe Pro  Gly Met Pro Gly Glu  Ser Gly Ser Gln Gly  Ile Arg Gly 
    1040                 1045                 1050             


Ser Pro  Gly Leu Pro Gly Ala  Ser Gly Leu Pro Gly  Leu Lys Gly 
    1055                 1060                 1065             


Asp Asn  Gly Gln Thr Val Glu  Ile Ser Gly Ser Pro  Gly Pro Lys 
    1070                 1075                 1080             


Gly Gln  Pro Gly Glu Ser Gly  Phe Lys Gly Thr Lys  Gly Arg Asp 
    1085                 1090                 1095             


Gly Leu  Ile Gly Asn Ile Gly  Phe Pro Gly Asn Lys  Gly Glu Asp 
    1100                 1105                 1110             


Gly Lys  Val Gly Val Ser Gly  Asp Val Gly Leu Pro  Gly Ala Pro 
    1115                 1120                 1125             


Gly Phe  Pro Gly Val Ala Gly  Met Arg Gly Glu Pro  Gly Leu Pro 
    1130                 1135                 1140             


Gly Ser  Ser Gly His Gln Gly  Ala Ile Gly Pro Leu  Gly Ser Pro 
    1145                 1150                 1155             


Gly Leu  Ile Gly Pro Lys Gly  Phe Pro Gly Phe Pro  Gly Leu His 
    1160                 1165                 1170             


Gly Leu  Asn Gly Leu Pro Gly  Thr Lys Gly Thr His  Gly Thr Pro 
    1175                 1180                 1185             


Gly Pro  Ser Ile Thr Gly Val  Pro Gly Pro Ala Gly  Leu Pro Gly 
    1190                 1195                 1200             


Pro Lys  Gly Glu Lys Gly Tyr  Pro Gly Ile Gly Ile  Gly Ala Pro 
    1205                 1210                 1215             


Gly Lys  Pro Gly Leu Arg Gly  Gln Lys Gly Asp Arg  Gly Phe Pro 
    1220                 1225                 1230             


Gly Leu  Gln Gly Pro Ala Gly  Leu Pro Gly Ala Pro  Gly Ile Ser 
    1235                 1240                 1245             


Leu Pro  Ser Leu Ile Ala Gly  Gln Pro Gly Asp Pro  Gly Arg Pro 
    1250                 1255                 1260             


Gly Leu  Asp Gly Glu Arg Gly  Arg Pro Gly Pro Ala  Gly Pro Pro 
    1265                 1270                 1275             


Gly Pro  Pro Gly Pro Ser Ser  Asn Gln Gly Asp Thr  Gly Asp Pro 
    1280                 1285                 1290             


Gly Phe  Pro Gly Ile Pro Gly  Phe Ser Gly Leu Pro  Gly Glu Leu 
    1295                 1300                 1305             


Gly Leu  Lys Gly Met Arg Gly  Glu Pro Gly Phe Met  Gly Thr Pro 
    1310                 1315                 1320             


Gly Lys  Val Gly Pro Pro Gly  Asp Pro Gly Phe Pro  Gly Met Lys 
    1325                 1330                 1335             


Gly Lys  Ala Gly Ala Arg Gly  Ser Ser Gly Leu Gln  Gly Asp Pro 
    1340                 1345                 1350             


Gly Gln  Thr Pro Thr Ala Glu  Ala Val Gln Val Pro  Pro Gly Pro 
    1355                 1360                 1365             


Leu Gly  Leu Pro Gly Ile Asp  Gly Ile Pro Gly Leu  Thr Gly Asp 
    1370                 1375                 1380             


Pro Gly  Ala Gln Gly Pro Val  Gly Leu Gln Gly Ser  Lys Gly Leu 
    1385                 1390                 1395             


Pro Gly  Ile Pro Gly Lys Asp  Gly Pro Ser Gly Leu  Pro Gly Pro 
    1400                 1405                 1410             


Pro Gly  Ala Leu Gly Asp Pro  Gly Leu Pro Gly Leu  Gln Gly Pro 
    1415                 1420                 1425             


Pro Gly  Phe Glu Gly Ala Pro  Gly Gln Gln Gly Pro  Phe Gly Met 
    1430                 1435                 1440             


Pro Gly  Met Pro Gly Gln Ser  Met Arg Val Gly Tyr  Thr Leu Val 
    1445                 1450                 1455             


Lys His  Ser Gln Ser Glu Gln  Val Pro Pro Cys Pro  Ile Gly Met 
    1460                 1465                 1470             


Ser Gln  Leu Trp Val Gly Tyr  Ser Leu Leu Phe Val  Glu Gly Gln 
    1475                 1480                 1485             


Glu Lys  Ala His Asn Gln Asp  Leu Gly Phe Ala Gly  Ser Cys Leu 
    1490                 1495                 1500             


Pro Arg  Phe Ser Thr Met Pro  Phe Ile Tyr Cys Asn  Ile Asn Glu 
    1505                 1510                 1515             


Val Cys  His Tyr Ala Arg Arg  Asn Asp Lys Ser Tyr  Trp Leu Ser 
    1520                 1525                 1530             


Thr Thr  Ala Pro Ile Pro Met  Met Pro Val Ser Gln  Thr Gln Ile 
    1535                 1540                 1545             


Pro Gln  Tyr Ile Ser Arg Cys  Ser Val Cys Glu Ala  Pro Ser Gln 
    1550                 1555                 1560             


Ala Ile  Ala Val His Ser Gln  Asp Ile Thr Ile Pro  Gln Cys Pro 
    1565                 1570                 1575             


Leu Gly  Trp Arg Ser Leu Trp  Ile Gly Tyr Ser Phe  Leu Met His 
    1580                 1585                 1590             


Thr Ala  Ala Gly Ala Glu Gly  Gly Gly Gln Ser Leu  Val Ser Pro 
    1595                 1600                 1605             


Gly Ser  Cys Leu Glu Asp Phe  Arg Ala Thr Pro Phe  Ile Glu Cys 
    1610                 1615                 1620             


Ser Gly  Ala Arg Gly Thr Cys  His Tyr Phe Ala Asn  Lys Tyr Ser 
    1625                 1630                 1635             


Phe Trp  Leu Thr Thr Val Glu  Glu Arg Gln Gln Phe  Gly Glu Leu 
    1640                 1645                 1650             


Pro Val  Ser Glu Thr Leu Lys  Ala Gly Gln Leu His  Thr Arg Val 
    1655                 1660                 1665             


Ser Arg  Cys Gln Val Cys Met  Lys Ser Leu 
    1670                 1675             


<210> 9
<211> 11
<212> PRT
<213> Homo sapiens

<400> 9
Gly Pro Arg Val Val Glu Arg His Gln Ser Ala 
1               5                   10      


<210> 10
<211> 224
<212> PRT
<213> Homo sapiens

<400> 10
Asp Ala Gly Asp Ala Phe Asp Gly Phe Asp Phe Gly Asp Asp Pro Ser 
1               5                   10                  15      


Asp Lys Phe Phe Thr Ser His Asn Gly Met Gln Phe Ser Thr Trp Asp 
            20                  25                  30          


Asn Asp Asn Asp Lys Phe Glu Gly Asn Cys Ala Glu Gln Asp Gly Ser 
        35                  40                  45              


Gly Trp Trp Met Asn Lys Cys His Ala Gly His Leu Asn Gly Val Tyr 
    50                  55                  60                  


Tyr Gln Gly Gly Thr Tyr Ser Lys Ala Ser Thr Pro Asn Gly Tyr Asp 
65                  70                  75                  80  


Asn Gly Ile Ile Trp Ala Thr Trp Lys Thr Arg Trp Tyr Ser Met Lys 
                85                  90                  95      


Lys Thr Thr Met Lys Ile Ile Pro Phe Asn Arg Leu Thr Ile Gly Glu 
            100                 105                 110         


Gly Gln Gln His His Leu Gly Gly Ala Lys Gln Ala Gly Asp Val Trp 
        115                 120                 125             


Asp Asn Asp Asn Asp Lys Phe Glu Gly Asn Cys Ala Glu Gln Asp Gly 
    130                 135                 140                 


Ser Gly Trp Trp Met Asn Lys Cys His Ala Gly His Leu Asn Gly Val 
145                 150                 155                 160 


Tyr Tyr Gln Gly Gly Thr Tyr Ser Lys Ala Ser Thr Pro Asn Gly Tyr 
                165                 170                 175     


Asp Asn Gly Ile Ile Trp Ala Thr Trp Lys Thr Arg Trp Tyr Ser Met 
            180                 185                 190         


Lys Lys Thr Thr Met Lys Ile Ile Pro Phe Asn Arg Leu Thr Ile Gly 
        195                 200                 205             


Glu Gly Gln Gln His His Leu Gly Gly Ala Lys Gln Ala Gly Asp Val 
    210                 215                 220                 


<210> 11
<211> 131
<212> PRT
<213> Homo sapiens

<400> 11
Ala Asn Arg Ser Arg Thr Glu Ala Glu Ser Trp Tyr Gln Thr Lys Tyr 
1               5                   10                  15      


Glu Glu Leu Gln Gln Thr Ala Gly Arg His Gly Asp Asp Leu Arg Asn 
            20                  25                  30          


Thr Lys His Glu Ile Ser Glu Met Asn Arg Met Ile Gln Arg Leu Arg 
        35                  40                  45              


Ala Glu Ile Asp Asn Val Lys Lys Gln Cys Ala Asn Leu Gln Asn Ala 
    50                  55                  60                  


Ile Ala Asp Ala Glu Gln Arg Gly Glu Leu Ala Leu Lys Asp Ala Arg 
65                  70                  75                  80  


Asn Lys Leu Ala Glu Leu Glu Glu Ala Leu Gln Lys Ala Lys Gln Asp 
                85                  90                  95      


Met Ala Arg Leu Leu Arg Glu Tyr Gln Glu Leu Met Asn Thr Lys Leu 
            100                 105                 110         


Ala Leu Asp Val Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu 
        115                 120                 125             


Glu Cys Arg 
    130     


<210> 12
<211> 129
<212> PRT
<213> Homo sapiens

<400> 12
Ala Glu Lys Asn Arg Lys Asp Ala Glu Glu Trp Phe Phe Thr Lys Thr 
1               5                   10                  15      


Glu Glu Leu Asn Arg Glu Val Ala Thr Asn Ser Glu Leu Val Gln Ser 
            20                  25                  30          


Gly Lys Ser Glu Ile Ser Glu Leu Arg Arg Thr Met Gln Asn Leu Glu 
        35                  40                  45              


Ile Glu Leu Gln Ser Gln Leu Ser Met Lys Ala Ser Leu Glu Asn Ser 
    50                  55                  60                  


Leu Glu Glu Thr Lys Gly Arg Tyr Cys Met Gln Leu Ala Gln Ile Gln 
65                  70                  75                  80  


Glu Met Ile Gly Ser Val Glu Glu Gln Leu Ala Gln Leu Arg Cys Glu 
                85                  90                  95      


Met Glu Gln Gln Asn Gln Glu Tyr Lys Ile Leu Leu Asp Val Lys Thr 
            100                 105                 110         


Arg Leu Glu Gln Glu Ile Ala Thr Tyr Arg Arg Leu Leu Glu Gly Glu 
        115                 120                 125             


Asp 
    


<210> 13
<211> 4
<212> PRT
<213> Homo sapiens

<400> 13
Gly His Arg Pro 
1               


