                         SEQUENCE LISTING

<110>  Stichting Het Nederlands Kanker Instituut - Antoni van
       Leeuwenhoek Ziekenhuis
 
<120>  TWEAK-receptor agonists for use in combination with immunotherapy
        of a cancer

<130>  P6082846PCT

<150>  EP18180732.2
<151>  2018-06-29

<150>  EP19171309.8
<151>  2019-04-26

<160>  73    

<170>  PatentIn version 3.5

<210>  1
<211>  98
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequencing Primer Gecko Forward


<220>
<221>  misc_feature
<222>  (59)..(64)
<223>  n is a, c, g, or t

<400>  1
aatgatacgg cgaccaccga gatctacact ctttccctac acgacgctct tccgatctnn       60

nnnnggcttt atatatcttg tggaaaggac gaaacacc                               98


<210>  2
<211>  46
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequencing Primer Gecko Reverse

<400>  2
caagcagaag acggcatacg agatccgact cggtgccatt tttcaa                      46


<210>  3
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  B2M sgRNA 1

<400>  3
cgtgagtaaa cctgaatctt                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  B2M sgRNA 1

<400>  4
cgtgagtaaa cctgaatctt                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  B2M sgRNA 2

<400>  5
cagtaagtca acttcaatgt                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  BIRC2 sgRNA 1

<400>  6
atatcctcat cttcttgaac                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  BIRC2 sgRNA 1

<400>  7
atatcctcat cttcttgaac                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  BIRC2 sgRNA 2

<400>  8
ggcttgaggt gttgggaatc                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  BIRC2 sgRNA 3

<400>  9
acatcatcat tgcgaccttc                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  BIRC2 sgRNA 4

<400>  10
tgtttgctgc gcccgcactg                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  BIRC2 sgRNA 5

<400>  11
atgatgctat gtcagaacac                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  BIRC3 sgRNA 1

<400>  12
tctactaaag cccatttcca                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  BIRC3 sgRNA 2

<400>  13
ggtaactggc ttgaacttga                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  BIRC3 sgRNA 3

<400>  14
gagagtttga ataagagcca                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CFLAR sgRNA 1

<400>  15
gtttctccaa ctcaaccaca                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CFLAR sgRNA 1

<400>  16
gtttctccaa ctcaaccaca                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CFLAR sgRNA 2

<400>  17
gggccgaggc aagataagca                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Human non-targeting control sgRNA 1

<400>  18
ggttgctgtg acgaacgggg                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Human non-targeting control sgRNA 2

<400>  19
ggttgctgtg acgaacgggg                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Human non-targeting control sgRNA 3

<400>  20
gcacgaggtg aacagccgct                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IFNGR1 sgRNA 1

<400>  21
cgaacgacgg tacctgagga                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IKBKG sgRNA 1

<400>  22
tcaggagcgc cctgttctga                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IKBKG sgRNA 2

<400>  23
ctcaccgacc ctccagagcc                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  KBKG sgRNA 1

<400>  24
tcaggagcgc cctgttctga                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MAP3K7 sgRNA 1

<400>  25
agagcctgat gactcgttgt                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MAP3K7 sgRNA 1

<400>  26
agagcctgat gactcgttgt                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MAP3K7 sgRNA 2

<400>  27
gatggagtta tctgatccat                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mouse B2m sgRNA 1

<400>  28
actctggata gcatacaggc                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mouse non-targeting control sgRNA 1

<400>  29
gtattactga tattggtggg                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mouse Traf2 sgRNA 1

<400>  30
taacgctgcc cgcagagagg                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RIPK1 sgRNA 1

<400>  31
gagagtgcag aactggacag                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RIPK1 sgRNA 2

<400>  32
agcgcgacac ggagactagg                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RIPK1 sgRNA 3

<400>  33
cttcctctat gatgacgccc                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TBK1 sgRNA 1

<400>  34
atcacttctt tattcctacg                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TBK1 sgRNA 1

<400>  35
atcacttctt tattcctacg                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TBK1 sgRNA 2

<400>  36
gaagaacctt ctaatgccta                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRADD sgRNA 1

<400>  37
tccctcgcgc tcgtactcgt                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRADD sgRNA 1

<400>  38
tccctcgcgc tcgtactcgt                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRADD sgRNA 2

<400>  39
caccgagtgc tgggcgagcg                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRAF1 sgRNA 1

<400>  40
atggctacaa gttgtgcctg                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRAF1 sgRNA 2

<400>  41
aggaagccgt cttcgaactc                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRAF1 sgRNA 3

<400>  42
caccgtctgc caggacccaa                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRAF2 sgRNA 1

<400>  43
cctgcagaaa cgtcctccgc                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRAF2 sgRNA 1

<400>  44
cctgcagaaa cgtcctccgc                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRAF2 sgRNA 2

<400>  45
atatatgccc tcgtgaacac                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRAF2 sgRNA 2

<400>  46
cctgcggagg acgtttctgc                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRAF2 sgRNA 3

<400>  47
accgaatgtc ccgcgtgcaa                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRAF2 sgRNA 3

<400>  48
gcggaggacg tttctgcagg                                                   20


<210>  49
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRAF2 sgRNA 4

<400>  49
gcctttgcac gcgggacatt                                                   20


<210>  50
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRAF2 sgRNA 4

<400>  50
ggggaccctg aaagaatacg                                                   20


<210>  51
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRAF2 sgRNA 5

<400>  51
ggggaccctg aaagaatacg                                                   20


<210>  52
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRAF2 sgRNA 6

<400>  52
atatatgccc tcgtgaacac                                                   20


<210>  53
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRAF2 sgRNA 7

<400>  53
cctgcggagg acgtttctgc                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRAF2 sgRNA 8

<400>  54
cctgcagaaa cgtcctccgc                                                   20


<210>  55
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRAF3 sgRNA 1

<400>  55
agacaccgac tgtccctgcg                                                   20


<210>  56
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRAF3 sgRNA 2

<400>  56
ggagaaggcg tgtaaatacc                                                   20


<210>  57
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRAF3 sgRNA 3

<400>  57
acacttgtac ttgtcctcca                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRAF4 sgRNA 1

<400>  58
tcctggagaa gcccaagcga                                                   20


<210>  59
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRAF4 sgRNA 2

<400>  59
cccccagatc tacccagacc                                                   20


<210>  60
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRAF4 sgRNA 3

<400>  60
agtgtgcagg tagatcacgg                                                   20


<210>  61
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRAF5 sgRNA 1

<400>  61
attctgggcc ggtaccaggt                                                   20


<210>  62
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRAF5 sgRNA 2

<400>  62
agtgccggga gccagtccta                                                   20


<210>  63
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRAF5 sgRNA 3

<400>  63
tagagtacca gtttgtggag                                                   20


<210>  64
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRAF6 sgRNA 1

<400>  64
acattctgaa ggattgtcca                                                   20


<210>  65
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRAF6 sgRNA 2

<400>  65
gattctacac tggcaaaccc                                                   20


<210>  66
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRAF6 sgRNA 3

<400>  66
gaagcagtgc aaacgccatg                                                   20


<210>  67
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRAF7 sgRNA 1

<400>  67
actccttcag gccctcgaag                                                   20


<210>  68
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRAF7 sgRNA 2

<400>  68
cagagatggc ggagtcggag                                                   20


<210>  69
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TRAF7 sgRNA 3

<400>  69
cgtggtggtg aacaacatcg                                                   20


<210>  70
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TSC1 sgRNA 1

<400>  70
cgagatagac ttccgccacg                                                   20


<210>  71
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TSC1 sgRNA 2

<400>  71
attcgttaat cctgtccaag                                                   20


<210>  72
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TSC2 sgRNA 1

<400>  72
agcacgcagt ggaagcactc                                                   20


<210>  73
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  TSC2 sgRNA 2

<400>  73
gtggcctcaa caatcgcatc                                                   20


