                         SEQUENCE LISTING

<110>  IMAGINE PHARMA
 
<120>  COMPOSITIONS AND METHODS FOR PROPOGATING INSULIN PRODUCING ISLET 
       CELLS AND THERAPEUTIC USES THEREOF

<130>  IMG007_PCT

<140>  PCT/US2019/038305
<141>  2019-06-20

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  293
<212>  PRT
<213>  HUMAN

<400>  1

Met Ala Asp Asp Ala Gly Ala Ala Gly Gly Pro Gly Gly Pro Gly Gly 
1               5                   10                  15      


Pro Gly Met Gly Asn Arg Gly Gly Phe Arg Gly Gly Phe Gly Ser Gly 
            20                  25                  30          


Ile Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg 
        35                  40                  45              


Gly Ala Arg Gly Gly Lys Ala Glu Asp Lys Glu Trp Met Pro Val Thr 
    50                  55                  60                  


Lys Leu Gly Arg Leu Val Lys Asp Met Lys Ile Lys Ser Leu Glu Glu 
65                  70                  75                  80  


Ile Tyr Leu Phe Ser Leu Pro Ile Lys Glu Ser Glu Ile Ile Asp Phe 
                85                  90                  95      


Phe Leu Gly Ala Ser Leu Lys Asp Glu Val Leu Lys Ile Met Pro Val 
            100                 105                 110         


Gln Lys Gln Thr Arg Ala Gly Gln Arg Thr Arg Phe Lys Ala Phe Val 
        115                 120                 125             


Ala Ile Gly Asp Tyr Asn Gly His Val Gly Leu Gly Val Lys Cys Ser 
    130                 135                 140                 


Lys Glu Val Ala Thr Ala Ile Arg Gly Ala Ile Ile Leu Ala Lys Leu 
145                 150                 155                 160 


Ser Ile Val Pro Val Arg Arg Gly Tyr Trp Gly Asn Lys Ile Gly Lys 
                165                 170                 175     


Pro His Thr Val Pro Cys Lys Val Thr Gly Arg Cys Gly Ser Val Leu 
            180                 185                 190         


Val Arg Leu Ile Pro Ala Pro Arg Gly Thr Gly Ile Val Ser Ala Pro 
        195                 200                 205             


Val Pro Lys Lys Leu Leu Met Met Ala Gly Ile Asp Asp Cys Tyr Thr 
    210                 215                 220                 


Ser Ala Arg Gly Cys Thr Ala Thr Leu Gly Asn Phe Ala Lys Ala Thr 
225                 230                 235                 240 


Phe Asp Ala Ile Ser Lys Thr Tyr Ser Tyr Leu Thr Pro Asp Leu Trp 
                245                 250                 255     


Lys Glu Thr Val Phe Thr Lys Ser Pro Tyr Gln Glu Phe Thr Asp His 
            260                 265                 270         


Leu Val Lys Thr His Thr Arg Val Ser Val Gln Arg Thr Gln Ala Pro 
        275                 280                 285             


Ala Val Ala Thr Thr 
    290             


<210>  2
<211>  158
<212>  PRT
<213>  HUMAN

<400>  2

Gly His Val Gly Leu Gly Val Lys Cys Ser Lys Glu Val Ala Thr Ala 
1               5                   10                  15      


Ile Arg Gly Ala Ile Ile Leu Ala Lys Leu Ile Val Pro Val Arg Arg 
            20                  25                  30          


Gly Tyr Trp Gly Asn Lys Ile Gly Lys Pro His Thr Val Pro Cys Lys 
        35                  40                  45              


Val Thr Gly Arg Cys Gly Ser Val Leu Val Arg Leu Ile Pro Ala Pro 
    50                  55                  60                  


Arg Gly Thr Gly Ile Val Ser Ala Pro Val Pro Lys Lys Leu Leu Met 
65                  70                  75                  80  


Met Ala Gly Ile Asp Asp Cys Tyr Thr Ser Ala Arg Gly Cys Thr Ala 
                85                  90                  95      


Thr Leu Gly Asn Phe Ala Lys Ala Thr Phe Asp Ala Ile Ser Lys Thr 
            100                 105                 110         


Tyr Ser Tyr Leu Thr Pro Asp Leu Trp Lys Glu Thr Val Phe Thr Lys 
        115                 120                 125             


Ser Pro Tyr Gln Glu Phe Thr Asp His Leu Val Lys Thr His Thr Arg 
    130                 135                 140                 


Val Ser Val Gln Arg Thr Gln Ala Pro Ala Val Ala Thr Thr 
145                 150                 155             


<210>  3
<211>  75
<212>  PRT
<213>  HUMAN

<400>  3

Ser Ile Val Pro Val Arg Arg Gly Tyr Trp Gly Asn Lys Ile Gly Lys 
1               5                   10                  15      


Pro His Thr Val Pro Cys Lys Val Thr Gly Arg Cys Gly Ser Val Leu 
            20                  25                  30          


Val Arg Leu Ile Pro Ala Pro Arg Gly Thr Gly Ile Val Ser Ala Pro 
        35                  40                  45              


Val Pro Lys Lys Leu Leu Met Met Ala Gly Ile Asp Asp Cys Tyr Thr 
    50                  55                  60                  


Ser Ala Arg Gly Cys Thr Ala Thr Leu Gly Asn 
65                  70                  75  


<210>  4
<211>  87
<212>  PRT
<213>  HUMAN

<400>  4

Gly His Val Gly Leu Gly Val Lys Cys Ser Lys Glu Val Ala Thr Ala 
1               5                   10                  15      


Ile Arg Gly Ala Ile Ile Leu Ala Lys Leu Ser Ile Val Pro Val Arg 
            20                  25                  30          


Arg Gly Tyr Trp Gly Asn Lys Ile Gly Lys Pro His Thr Val Pro Cys 
        35                  40                  45              


Lys Val Thr Gly Arg Cys Gly Ser Val Leu Val Arg Leu Ile Pro Ala 
    50                  55                  60                  


Pro Arg Gly Thr Gly Ile Val Ser Ala Pro Val Pro Lys Lys Leu Leu 
65                  70                  75                  80  


Met Met Ala Gly Ile Asp Asp 
                85          


