                         SEQUENCE LISTING

<110>  Lygos, Inc.
 
<120>  Recombinant Host Cells and Methods for the Production of Aspartic
        Acid and Beta-Alanine

<130>  LYGOS-0016-01-WO

<150>  62/689,265
<151>  2018-06-25

<160>  54    

<170>  PatentIn version 3.5

<210>  1
<211>  314
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  1

Met Lys Glu Thr Val Gly Asn Lys Ile Val Leu Ile Gly Ala Gly Asp 
1               5                   10                  15      


Val Gly Val Ala Tyr Ala Tyr Ala Leu Ile Asn Gln Gly Met Ala Asp 
            20                  25                  30          


His Leu Ala Ile Ile Asp Ile Asp Glu Lys Lys Leu Glu Gly Asn Val 
        35                  40                  45              


Met Asp Leu Asn His Gly Val Val Trp Ala Asp Ser Arg Thr Arg Val 
    50                  55                  60                  


Thr Lys Gly Thr Tyr Ala Asp Cys Glu Asp Ala Ala Met Val Val Ile 
65                  70                  75                  80  


Cys Ala Gly Ala Ala Gln Lys Pro Gly Glu Thr Arg Leu Gln Leu Val 
                85                  90                  95      


Asp Lys Asn Val Lys Ile Met Lys Ser Ile Val Gly Asp Val Met Asp 
            100                 105                 110         


Ser Gly Phe Asp Gly Ile Phe Leu Val Ala Ser Asn Pro Val Asp Ile 
        115                 120                 125             


Leu Thr Tyr Ala Val Trp Lys Phe Ser Gly Leu Glu Trp Asn Arg Val 
    130                 135                 140                 


Ile Gly Ser Gly Thr Val Leu Asp Ser Ala Arg Phe Arg Tyr Met Leu 
145                 150                 155                 160 


Gly Glu Leu Tyr Glu Val Ala Pro Ser Ser Val His Ala Tyr Ile Ile 
                165                 170                 175     


Gly Glu His Gly Asp Thr Glu Leu Pro Val Leu Ser Ser Ala Thr Ile 
            180                 185                 190         


Ala Gly Val Ser Leu Ser Arg Met Leu Asp Lys Asp Pro Glu Leu Glu 
        195                 200                 205             


Gly Arg Leu Glu Lys Ile Phe Glu Asp Thr Arg Asp Ala Ala Tyr His 
    210                 215                 220                 


Ile Ile Asp Ala Lys Gly Ser Thr Ser Tyr Gly Ile Gly Met Gly Leu 
225                 230                 235                 240 


Ala Arg Ile Thr Arg Ala Ile Leu Gln Asn Gln Asp Val Ala Val Pro 
                245                 250                 255     


Val Ser Ala Leu Leu His Gly Glu Tyr Gly Glu Glu Asp Ile Tyr Ile 
            260                 265                 270         


Gly Thr Pro Ala Val Val Asn Arg Arg Gly Ile Arg Arg Val Val Glu 
        275                 280                 285             


Leu Glu Ile Thr Asp His Glu Met Glu Arg Phe Lys His Ser Ala Asn 
    290                 295                 300                 


Thr Leu Arg Glu Ile Gln Lys Gln Phe Phe 
305                 310                 


<210>  2
<211>  257
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  2

Met Thr Val Arg Asn Pro Asp Arg Glu Ala Ile Arg His Gly Lys Ile 
1               5                   10                  15      


Thr Thr Glu Ala Leu Arg Glu Arg Pro Ala Tyr Pro Thr Trp Ala Met 
            20                  25                  30          


Lys Leu Thr Met Ala Ile Thr Gly Leu Met Phe Gly Gly Phe Val Leu 
        35                  40                  45              


Val His Met Ile Gly Asn Leu Lys Ile Phe Met Pro Asp Tyr Ala Ala 
    50                  55                  60                  


Asp Ser Ala His Pro Gly Glu Ala Gln Val Asp Val Tyr Gly Glu Phe 
65                  70                  75                  80  


Leu Arg Glu Ile Gly Ser Pro Ile Leu Pro His Gly Ser Val Leu Trp 
                85                  90                  95      


Ile Leu Arg Ile Ile Leu Leu Val Ala Leu Val Leu His Ile Tyr Cys 
            100                 105                 110         


Ala Phe Ala Leu Thr Gly Arg Ser His Gln Ser Arg Gly Lys Phe Arg 
        115                 120                 125             


Arg Thr Asn Leu Val Gly Gly Phe Asn Ser Phe Ala Thr Arg Ser Met 
    130                 135                 140                 


Leu Val Thr Gly Ile Val Leu Leu Ala Phe Ile Ile Phe His Ile Leu 
145                 150                 155                 160 


Asp Leu Thr Met Gly Val Ala Pro Ala Ala Pro Thr Ser Phe Glu His 
                165                 170                 175     


Gly Glu Val Tyr Ala Asn Met Val Ala Ser Phe Ser Arg Trp Pro Val 
            180                 185                 190         


Ala Ile Trp Tyr Ile Ile Ala Asn Leu Val Leu Phe Val His Leu Ser 
        195                 200                 205             


His Gly Ile Trp Leu Ala Val Ser Asp Leu Gly Ile Thr Gly Arg Arg 
    210                 215                 220                 


Trp Arg Ala Ile Leu Leu Ala Val Ala Tyr Ile Val Pro Ala Leu Val 
225                 230                 235                 240 


Leu Ile Gly Asn Ile Thr Ile Pro Phe Ala Ile Ala Val Gly Trp Ile 
                245                 250                 255     


Ala 
    


<210>  3
<211>  750
<212>  DNA
<213>  Corynebacterium glutamicum

<400>  3
agccgtaacc caccacggtt tcggcaacaa tgacggcgag agagcccacc acattgcgat       60

ttccgctccg ataaagccag cgcccatatt tgcagggagg attcgcctgc ggtttggcga      120

cattcggatc cccggaacta gctctgcaat gacctgcgcg ccgagggagg cgaggtgggt      180

ggcaggtttt agtgcgggtt taagcgttgc caggcgagtg gtgagcagag acgctagtct      240

ggggagcgaa accatattga gtcatcttgg cagagcatgc acaattctgc agggcatagg      300

ttggttttgc tcgatttaca atgtgatttt ttcaacaaaa ataacacttg gtctgaccac      360

attttcggac ataatcgggc ataattaaag gtgtaacaaa ggaatccggg cacaagctct      420

tgctgatttt ctgagctgct ttgtgggttg tccggttagg gaaatcagga agtgggatcg      480

aaaatgaaag aaaccgtcgg taacaagatt gtcctcattg gcgcaggaga tgttggagtt      540

gcatacgcat acgcactgat caaccagggc atggcagatc accttgcgat catcgacatc      600

gatgaaaaga aactcgaagg caacgtcatg gacttaaacc atggtgttgt gtgggccgat      660

tcccgcaccc gcgtcaccaa gggcacctac gctgactgcg aagacgcagc catggttgtc      720

atttgtgccg gcgcagccca aaagccaggc                                       750


<210>  4
<211>  750
<212>  DNA
<213>  Corynebacterium glutamicum

<400>  4
atcacattat cgacgccaag ggctccactt cctacggcat cggcatgggt cttgctcgca       60

tcacccgcgc aatcctgcag aaccaagacg ttgcagtccc agtctctgca ctgctccacg      120

gtgaatacgg tgaggaagac atctacatcg gcaccccagc tgtggtgaac cgccgaggca      180

tccgccgcgt tgtcgaacta gaaatcaccg accacgagat ggaacgcttc aagcattccg      240

caaataccct gcgcgaaatt cagaagcagt tcttctaaat ctttggcgcc tagttggcga      300

cgcaagtgtt tcattggaac acttgcgctg ccaacttttt ggtttacggg cacaatgaaa      360

ctgttggatg gaatttagag tgtttgtagc ttaaggagct caaatgaatg agtttgacca      420

ggacattctc caggagatca agactgaact cgacgagtta attctagaac ttgatgaggt      480

gacacaaact cacagcgagg ccatcgggca ggtctcccca acccattacg ttggtgcccg      540

caacctcatg cattacgcgc atcttcgcac caaagacctc cgtggcctgc agcaacgcct      600

ctcctctgtg ggagctaccc gcttgactac caccgaacca gcagtgcagg cccgcctcaa      660

ggccgcccgc aatgttatcg gagctttcgc aggtgaaggc ccactttatc caccctcaga      720

tgtcgtcgat gccttcgaag atgccgatga                                       750


<210>  5
<211>  885
<212>  DNA
<213>  Corynebacterium glutamicum

<400>  5
gtgagcgggc gtacgtcgtg ctcaatctga tttacataac ttgcagataa gccaagggtt       60

gctgctaagg atgcctggct caggtctctt tcgcggcgca gttggcgcag cctggacccc      120

acatatgtct ttcccatggc gcaactatag cgtgatcacc atcaccttaa ccactcttgg      180

cactgaggtg ttgcaaactt gttgattttc gcttttcgac gcagcccgcc gccaccaggt      240

gcccggcgtg gtcgggccac atccgccccg ggaacttttt aggcacctac ggtgcaactg      300

ttgggataat tgtgtcacct gcgcaaagtt gctccctgga tcggaaggtt gggctgtcta      360

aactttttgg ttgataccaa acggggttag aaactgttcg gatcggtatc ctgtgaggaa      420

gctcaccttg gttttagaat gttgaaaagg cctcacgttt ccgcaggtag agcacactca      480

attaaatgag cgtcaaacga caataaagta aggctatcct aataagtggg gttttatgtc      540

tctaaacagc cagttggggg tcatggggga gcgccccgtg actggttaat gccccgatct      600

gggacgtaca gtaacaacga cactggaggt gccatgactg ttagaaatcc cgaccgtgag      660

gcaatccgtc acggaaaaat tacgacggag gcgctgcgtg agcgtcccgc atacccgacc      720

tgggcaatga agctgaccat ggccatcact ggcctaatgt ttggtggctt cgttcttgtt      780

cacatgatcg gaaacctgaa aatcttcatg ccggactacg cagccgattc tgcgcatccg      840

ggtgaagcac aagtagatgt ctacggcgag ttcctgcgtg agatc                      885


<210>  6
<211>  885
<212>  DNA
<213>  Corynebacterium glutamicum

<400>  6
cacgtaagat ggttgatgaa atggaaacca acttcggaca ctgctccctc tacggcgagt       60

gcgcagatgt ctgccccgca ggcatcccac tgaccgctgt ggcagctgtc accaaggaac      120

gtgcgcgtgc agctttccga ggcaaagacg actagtcttt aatccaagta agtaccggtt      180

cagacagtta aaccagaaag acgagtgaac accatgtcct ccgcgaaaaa gaaacccgca      240

ccggagcgta tgcactacat caagggctat gtacctgtgg cgtatagctc tccacactca      300

tccctcgagc gcagcgcaac ctggttgggc atgggattcc tcctcactgc tctggcaggc      360

gttggcgcag tcctcttcgc agtcggcgca aacagcgttg gccagcagca ggaacactgg      420

gtcctctaca gcatcatcgg tgttgtattc gccgttgtct gcacagtttt gggcaccgtc      480

ctgatcatca agggccgagc accttacaac cgttacgtca aggaaaccgg ccgtacgcag      540

tagtttctgt atgcaggttc tttgactagc acctccaaca acaccctttc ttccatttat      600

gtgggggaga gggtgttgtt ttgtttttgc ttggagttcc ctggagcctt catcgacagc      660

ccccaagccc tcgaaaacgc cgaaagcaac ccactgtgga gccaactccc cgcagtcaaa      720

aacggtcaac tctgtaccac ggaaaacctc accccatgga tcctcaccgg accagcagca      780

gctgagattg tgacctctga cctcgaggca tgtttcgctg cttaggagac atggaagatt      840

ggtggaaatt gggtcgtgca gaaggatgct tggagatata ggata                      885


<210>  7
<211>  1517
<212>  PRT
<213>  Kluyveromyces marxianus

<400>  7

Met Ser Asn Ser Ser Ser Ser Glu Gly Lys Thr Asn Glu Asp Gly Arg 
1               5                   10                  15      


Asn Ser Val His Ser Ser Asp Ser Phe Ala Gln Ser Val Ala Ser Phe 
            20                  25                  30          


His Leu Asp Asp Asn Glu Ser Gln Asn Val Thr Ala Gln Leu Ser Gln 
        35                  40                  45              


Gln Ile Thr Asn Val Leu Ser Asn Ser Asn Gly Ala Glu Arg Ile Glu 
    50                  55                  60                  


Ser Leu Ala Arg Val Ile Ser Thr Lys Thr Lys Lys Gln Met Glu Ser 
65                  70                  75                  80  


Phe Glu Val Asn Gln Leu Asp Phe Asp Leu Lys Ala Leu Leu Asn Tyr 
                85                  90                  95      


Leu Arg Ser Ser Gln Leu Glu Gln Gly Ile Glu Pro Gly Asp Ser Gly 
            100                 105                 110         


Ile Ala Phe His Asp Leu Thr Ala Val Gly Ile Asp Ala Ser Ala Ala 
        115                 120                 125             


Phe Gly Pro Ser Val Glu Glu Met Val Arg Ser Trp Ile His Phe Pro 
    130                 135                 140                 


Val Arg Leu Trp Lys Lys Ile Cys Arg Gln Lys Ser Glu Thr Pro Leu 
145                 150                 155                 160 


Arg Asn Ile Ile Gln His Cys Thr Gly Val Val Glu Ser Gly Glu Met 
                165                 170                 175     


Leu Phe Val Val Gly Arg Pro Gly Ala Gly Cys Ser Thr Leu Leu Lys 
            180                 185                 190         


Cys Leu Ser Gly Glu Thr Gly Glu Leu Val Glu Val Thr Gly Asp Ile 
        195                 200                 205             


Ser Tyr Asp Gly Leu Ser Gln Glu Glu Met Met Gln Lys Phe Lys Gly 
    210                 215                 220                 


Tyr Val Ile Tyr Cys Pro Glu Leu Asp Phe His Phe Pro Lys Ile Thr 
225                 230                 235                 240 


Val Lys Glu Thr Ile Asp Phe Ala Leu Lys Cys Lys Thr Pro Arg Ser 
                245                 250                 255     


Arg Ile Asp His Leu Thr Arg Ala Gln Tyr Val Asp Asn Met Arg Asp 
            260                 265                 270         


Leu Trp Cys Thr Val Phe Gly Leu Thr His Thr Tyr Ala Thr Asn Val 
        275                 280                 285             


Gly Asn Asp Val Val Arg Gly Val Ser Gly Gly Glu Arg Lys Arg Val 
    290                 295                 300                 


Ser Leu Val Glu Ala Leu Ala Met Asn Ala Ser Ile Tyr Ser Trp Asp 
305                 310                 315                 320 


Asn Ala Thr Arg Gly Leu Asp Ala Ser Thr Ala Leu Glu Phe Ala Gln 
                325                 330                 335     


Ala Ile Arg Thr Ala Thr Asn Met Met Asn Asn Ser Ala Ile Val Ala 
            340                 345                 350         


Ile Tyr Gln Ala Gly Glu Asn Ile Tyr Gln Leu Phe Asp Lys Thr Thr 
        355                 360                 365             


Val Leu Tyr Asn Gly Lys Gln Val Tyr Phe Gly Pro Ala Asp Glu Ala 
    370                 375                 380                 


Val Gly Tyr Phe Glu Arg Met Gly Tyr Ile Lys Pro Asn Arg Met Thr 
385                 390                 395                 400 


Ser Ala Glu Phe Leu Thr Ser Ala Thr Val Asp Phe Glu Asn Arg Thr 
                405                 410                 415     


Leu Glu Val Arg Glu Gly Tyr Glu Glu Lys Ile Pro Lys Ser Ser Thr 
            420                 425                 430         


Glu Met Glu Ala Tyr Trp His Asn Ser Pro Glu Tyr Ala Lys Ala Thr 
        435                 440                 445             


Glu Leu Phe Asn Glu Tyr Cys Gln Ser His Pro Glu Glu Glu Thr Arg 
    450                 455                 460                 


Gln Arg Leu Glu Thr Ala Lys Lys Gln Arg Leu Gln Lys Gly Gln Arg 
465                 470                 475                 480 


Glu Lys Ser Gln Phe Val Val Thr Phe Trp Ala Gln Val Trp Tyr Cys 
                485                 490                 495     


Met Ile Arg Gly Phe Gln Arg Val Lys Gly Asp Ser Thr Tyr Thr Lys 
            500                 505                 510         


Val Tyr Leu Ser Ser Phe Leu Thr Lys Gly Leu Ile Val Gly Ser Met 
        515                 520                 525             


Phe His Lys Ile Asp Pro Lys Ser Gln Ser Thr Thr Glu Gly Ala Tyr 
    530                 535                 540                 


Ser Arg Gly Gly Leu Leu Phe Tyr Val Leu Leu Phe Ala Ala Leu Thr 
545                 550                 555                 560 


Ser Leu Ala Glu Ile Ser Asn Ser Phe Gln Asn Arg Ala Ile Ile Val 
                565                 570                 575     


Lys Gln Lys Thr Tyr Ser Met Tyr His Thr Ser Ala Glu Ser Leu Gln 
            580                 585                 590         


Glu Ile Phe Thr Glu Ile Pro Thr Lys Phe Val Ala Ile Leu Thr Leu 
        595                 600                 605             


Ser Leu Val Ser Tyr Trp Ile Pro Val Leu Lys Tyr Asp Ala Gly Ser 
    610                 615                 620                 


Phe Phe Gln Tyr Leu Leu Tyr Leu Phe Thr Thr Gln Gln Cys Thr Ser 
625                 630                 635                 640 


Phe Ile Phe Lys Leu Val Ala Thr Leu Thr Lys Asp Gly Gly Thr Ala 
                645                 650                 655     


His Ala Ile Gly Gly Leu Trp Val Leu Met Leu Thr Val Tyr Ala Gly 
            660                 665                 670         


Phe Val Leu Pro Ile Gly Asn Met His His Trp Ile Arg Trp Phe His 
        675                 680                 685             


Tyr Leu Asn Pro Leu Thr Tyr Ala Tyr Glu Ser Leu Met Ser Thr Glu 
    690                 695                 700                 


Phe His Gly Arg Lys Met Leu Cys Ser Arg Leu Leu Pro Ser Gly Pro 
705                 710                 715                 720 


Gly Tyr Glu Asn Val Ser Ile Ala His Lys Ile Cys Asp Ala Ala Gly 
                725                 730                 735     


Ala Val Ala Gly Gln Leu Tyr Val Ser Gly Asp Ala Tyr Val Leu Lys 
            740                 745                 750         


Lys Tyr His Phe Arg Tyr Lys His Ala Trp Arg Asp Trp Gly Ile Asn 
        755                 760                 765             


Ile Val Trp Thr Phe Gly Tyr Ile Val Met Asn Val Val Met Ser Glu 
    770                 775                 780                 


Tyr Leu Lys Pro Leu Glu Gly Gly Gly Asp Leu Leu Leu Tyr Lys Arg 
785                 790                 795                 800 


Gly His Met Pro Glu Leu Gly Ser Glu Ser Val Asp Ser Lys Val Ala 
                805                 810                 815     


Ser Arg Glu Glu Met Met Glu Ser Leu Asn Gly Pro Gly Val Asp Leu 
            820                 825                 830         


Glu Lys Val Ile Ala Ser Lys Asp Val Phe Thr Trp Asn His Leu Asn 
        835                 840                 845             


Tyr Thr Ile Pro Tyr Asp Gly Ala Thr Arg Gln Leu Leu Ser Asp Val 
    850                 855                 860                 


Phe Gly Tyr Val Lys Pro Gly Lys Met Thr Ala Leu Met Gly Glu Ser 
865                 870                 875                 880 


Gly Ala Gly Lys Thr Thr Leu Leu Asn Val Leu Ala Gln Arg Ile Asn 
                885                 890                 895     


Val Gly Val Ile Thr Gly Asp Met Leu Val Asn Ala Lys Pro Leu Pro 
            900                 905                 910         


Pro Ser Phe Asn Arg Ser Cys Gly Tyr Val Ala Gln Ala Asp Asn His 
        915                 920                 925             


Met Gly Glu Leu Ser Val Arg Glu Ser Leu Arg Phe Ala Ala Glu Leu 
    930                 935                 940                 


Arg Gln Pro Lys Ser Val Pro Leu Gln Glu Lys Tyr Asp Tyr Val Glu 
945                 950                 955                 960 


Lys Ile Ile Ser Leu Leu Gly Met Glu Lys Tyr Ala Glu Ala Ile Ile 
                965                 970                 975     


Gly Lys Thr Gly Arg Gly Leu Asn Val Glu Gln Arg Lys Lys Leu Ser 
            980                 985                 990         


Ile Gly Val Glu Leu Val Ala Lys  Pro Ser Leu Leu Leu  Phe Leu Asp 
        995                 1000                 1005             


Glu Pro  Thr Ser Gly Leu Asp  Ser Gln Ser Ala Trp  Ser Ile Val 
    1010                 1015                 1020             


Gln Phe  Met Arg Ala Leu Ala  Asp Ser Gly Gln Ser  Ile Leu Cys 
    1025                 1030                 1035             


Thr Ile  His Gln Pro Ser Ala  Thr Leu Phe Glu Gln  Phe Asp Arg 
    1040                 1045                 1050             


Leu Leu  Leu Leu Lys Lys Gly  Gly Lys Met Val Tyr  Phe Gly Asp 
    1055                 1060                 1065             


Ile Gly  Glu Asn Ser Ser Thr  Leu Leu Asn Tyr Phe  Glu Arg Gln 
    1070                 1075                 1080             


Ser Gly  Val Lys Cys Gly Lys  Ser Glu Asn Pro Ala  Glu Tyr Met 
    1085                 1090                 1095             


Leu Asn  Cys Ile Gly Ala Gly  Ala Thr Ala Ser Ala  Asp Ala Asp 
    1100                 1105                 1110             


Trp His  Asp Leu Trp Leu Gln  Ser Pro Glu Cys Ala  Ala Ala Arg 
    1115                 1120                 1125             


Glu Glu  Val Glu Glu Leu His  Arg Thr Leu Ala Ser  Arg Pro Val 
    1130                 1135                 1140             


Thr Asp  Asp Lys Glu Leu Ala  Gly Arg Tyr Ala Ala  Ser Tyr Leu 
    1145                 1150                 1155             


Thr Gln  Met Lys Cys Val Phe  Arg Arg Thr Asn Ile  Gln Phe Trp 
    1160                 1165                 1170             


Arg Ser  Pro Val Tyr Ile Arg  Ala Lys Phe Leu Glu  Cys Val Leu 
    1175                 1180                 1185             


Cys Ala  Leu Phe Val Gly Leu  Ser Tyr Val Gly Val  Asp His Ser 
    1190                 1195                 1200             


Ile Ala  Gly Ala Ser Gln Ser  Phe Ser Ser Ile Phe  Met Met Leu 
    1205                 1210                 1215             


Leu Ile  Ala Leu Ala Met Val  Asn Gln Leu His Val  Phe Ala Leu 
    1220                 1225                 1230             


Asp Ser  Arg Glu Leu Tyr Glu  Val Arg Glu Ala Ala  Ser Asn Thr 
    1235                 1240                 1245             


Phe His  Trp Ser Val Leu Leu  Leu Asn His Thr Phe  Val Glu Ile 
    1250                 1255                 1260             


Ile Trp  Ser Thr Leu Cys Glu  Phe Ile Cys Trp Ile  Cys Tyr Tyr 
    1265                 1270                 1275             


Trp Pro  Ala Gln Tyr Ser Gly  Arg Ala Ser His Ala  Gly Tyr Phe 
    1280                 1285                 1290             


Phe Leu  Ile Tyr Val Ile Met  Phe Pro Ala Tyr Phe  Val Ser Tyr 
    1295                 1300                 1305             


Gly Cys  Trp Val Phe Tyr Met  Ser Pro Asp Val Pro  Ser Ala Ser 
    1310                 1315                 1320             


Met Ile  Asn Ser Asn Leu Phe  Ala Gly Met Leu Leu  Phe Cys Gly 
    1325                 1330                 1335             


Ile Leu  Gln Pro Lys Asp Lys  Met Pro Gly Phe Trp  Lys Arg Phe 
    1340                 1345                 1350             


Met Tyr  Asn Val Ser Pro Phe  Thr Tyr Val Val Gln  Ser Leu Val 
    1355                 1360                 1365             


Thr Pro  Leu Val Gln Gly Lys  Lys Val Arg Cys Thr  Lys Asn Glu 
    1370                 1375                 1380             


Phe Ala  Val Val Asn Pro Pro  Glu Gly Gln Thr Cys  Ser Gln Tyr 
    1385                 1390                 1395             


Phe Ala  Arg Phe Ile Lys Asp  Asn Thr Gly Tyr Leu  Lys Asn Pro 
    1400                 1405                 1410             


Asn Asp  Thr Glu Ser Cys His  Tyr Cys Pro Tyr Ser  Tyr Gln Gln 
    1415                 1420                 1425             


Glu Val  Val Glu Gln Tyr Asn  Val Arg Trp Val Tyr  Arg Trp Arg 
    1430                 1435                 1440             


Asn Phe  Gly Phe Leu Trp Ala  Tyr Ile Gly Phe Asn  Phe Phe Ala 
    1445                 1450                 1455             


Met Leu  Ala Cys Tyr Trp Val  Leu Arg Val Lys Asn  Tyr Ser Ile 
    1460                 1465                 1470             


Thr Ser  Ile Phe Gly Val Phe  Lys Ile Gly Asn Trp  Lys Lys Ala 
    1475                 1480                 1485             


Ile His  His Asp Ser Arg His  Glu Lys Asp His Thr  Ile Phe Gln 
    1490                 1495                 1500             


Glu Lys  Pro Gly Asp Ala Ala  Asn Val Gln Lys Thr  Lys Ala 
    1505                 1510                 1515         


<210>  8
<211>  328
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  8

Met Asn Ser Pro Gln Asn Val Ser Thr Lys Lys Val Thr Val Thr Gly 
1               5                   10                  15      


Ala Ala Gly Gln Ile Ser Tyr Ser Leu Leu Trp Arg Ile Ala Asn Gly 
            20                  25                  30          


Glu Val Phe Gly Thr Asp Thr Pro Val Glu Leu Lys Leu Leu Glu Ile 
        35                  40                  45              


Pro Gln Ala Leu Gly Gly Ala Glu Gly Val Ala Met Glu Leu Leu Asp 
    50                  55                  60                  


Ser Ala Phe Pro Leu Leu Arg Asn Ile Thr Ile Thr Ala Asp Ala Asn 
65                  70                  75                  80  


Glu Ala Phe Asp Gly Ala Asn Ala Ala Phe Leu Val Gly Ala Lys Pro 
                85                  90                  95      


Arg Gly Lys Gly Glu Glu Arg Ala Asp Leu Leu Ala Asn Asn Gly Lys 
            100                 105                 110         


Ile Phe Gly Pro Gln Gly Lys Ala Ile Asn Asp Asn Ala Ala Asp Asp 
        115                 120                 125             


Ile Arg Val Leu Val Val Gly Asn Pro Ala Asn Thr Asn Ala Leu Ile 
    130                 135                 140                 


Ala Ser Ala Ala Ala Pro Asp Val Pro Ala Ser Arg Phe Asn Ala Met 
145                 150                 155                 160 


Met Arg Leu Asp His Asn Arg Ala Ile Ser Gln Leu Ala Thr Lys Leu 
                165                 170                 175     


Gly Arg Gly Ser Ala Glu Phe Asn Asn Ile Val Val Trp Gly Asn His 
            180                 185                 190         


Ser Ala Thr Gln Phe Pro Asp Ile Thr Tyr Ala Thr Val Gly Gly Glu 
        195                 200                 205             


Lys Val Thr Asp Leu Val Asp His Asp Trp Tyr Val Glu Glu Phe Ile 
    210                 215                 220                 


Pro Arg Val Ala Asn Arg Gly Ala Glu Ile Ile Glu Val Arg Gly Lys 
225                 230                 235                 240 


Ser Ser Ala Ala Ser Ala Ala Ser Ser Ala Ile Asp His Met Arg Asp 
                245                 250                 255     


Trp Val Gln Gly Thr Glu Ala Trp Ser Ser Ala Ala Ile Pro Ser Thr 
            260                 265                 270         


Gly Ala Tyr Gly Ile Pro Glu Gly Ile Phe Val Gly Leu Pro Thr Val 
        275                 280                 285             


Ser Arg Asn Gly Glu Trp Glu Ile Val Glu Gly Leu Glu Ile Ser Asp 
    290                 295                 300                 


Phe Gln Arg Ala Arg Ile Asp Ala Asn Ala Gln Glu Leu Gln Ala Glu 
305                 310                 315                 320 


Arg Glu Ala Val Arg Asp Leu Leu 
                325             


<210>  9
<211>  268
<212>  PRT
<213>  Cupriavidus necator

<400>  9

Met Ser Met Leu His Val Ser Met Val Gly Cys Gly Ala Ile Gly Arg 
1               5                   10                  15      


Gly Val Leu Glu Leu Leu Lys Ala Asp Pro Asp Val Ala Phe Asp Val 
            20                  25                  30          


Val Ile Val Pro Glu Gly Gln Met Asp Glu Ala Arg Ser Ala Leu Ser 
        35                  40                  45              


Ala Leu Ala Pro Asn Val Arg Val Ala Thr Gly Leu Asp Gly Gln Arg 
    50                  55                  60                  


Pro Asp Leu Leu Val Glu Cys Ala Gly His Gln Ala Leu Glu Glu His 
65                  70                  75                  80  


Ile Val Pro Ala Leu Glu Arg Gly Ile Pro Cys Met Val Val Ser Val 
                85                  90                  95      


Gly Ala Leu Ser Glu Pro Gly Leu Val Glu Arg Leu Glu Ala Ala Ala 
            100                 105                 110         


Arg Arg Gly Asn Thr Gln Val Gln Leu Leu Ser Gly Ala Ile Gly Ala 
        115                 120                 125             


Ile Asp Ala Leu Ala Ala Ala Arg Val Gly Gly Leu Asp Glu Val Ile 
    130                 135                 140                 


Tyr Thr Gly Arg Lys Pro Ala Arg Ala Trp Thr Gly Thr Pro Ala Ala 
145                 150                 155                 160 


Glu Leu Phe Asp Leu Glu Ala Leu Thr Glu Pro Thr Val Ile Phe Glu 
                165                 170                 175     


Gly Thr Ala Arg Asp Ala Ala Arg Leu Tyr Pro Lys Asn Ala Asn Val 
            180                 185                 190         


Ala Ala Thr Val Ser Leu Ala Gly Leu Gly Leu Asp Arg Thr Ser Val 
        195                 200                 205             


Arg Leu Leu Ala Asp Pro Asn Ala Val Glu Asn Val His His Ile Glu 
    210                 215                 220                 


Ala Arg Gly Ala Phe Gly Gly Phe Glu Leu Thr Met Arg Gly Lys Pro 
225                 230                 235                 240 


Leu Ala Ala Asn Pro Lys Thr Ser Ala Leu Thr Val Phe Ser Val Val 
                245                 250                 255     


Arg Ala Leu Gly Asn Arg Ala His Ala Val Ser Ile 
            260                 265             


<210>  10
<211>  673
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  10

Met Ser Thr His Ser Glu Thr Thr Arg Pro Glu Phe Ile His Pro Val 
1               5                   10                  15      


Ser Val Leu Pro Glu Val Ser Ala Gly Thr Val Leu Asp Ala Ala Glu 
            20                  25                  30          


Pro Ala Gly Val Pro Thr Lys Asp Met Trp Glu Tyr Gln Lys Asp His 
        35                  40                  45              


Met Asn Leu Val Ser Pro Leu Asn Arg Arg Lys Phe Arg Val Leu Val 
    50                  55                  60                  


Val Gly Thr Gly Leu Ser Gly Gly Ala Ala Ala Ala Ala Leu Gly Glu 
65                  70                  75                  80  


Leu Gly Tyr Asp Val Lys Ala Phe Thr Tyr His Asp Ala Pro Arg Arg 
                85                  90                  95      


Ala His Ser Ile Ala Ala Gln Gly Gly Val Asn Ser Ala Arg Gly Lys 
            100                 105                 110         


Lys Val Asp Asn Asp Gly Ala Tyr Arg His Val Lys Asp Thr Val Lys 
        115                 120                 125             


Gly Gly Asp Tyr Arg Gly Arg Glu Ser Asp Cys Trp Arg Leu Ala Val 
    130                 135                 140                 


Glu Ser Val Arg Val Ile Asp His Met Asn Ala Ile Gly Ala Pro Phe 
145                 150                 155                 160 


Ala Arg Glu Tyr Gly Gly Ala Leu Ala Thr Arg Ser Phe Gly Gly Val 
                165                 170                 175     


Gln Val Ser Arg Thr Tyr Tyr Thr Arg Gly Gln Thr Gly Gln Gln Leu 
            180                 185                 190         


Gln Leu Ser Thr Ala Ser Ala Leu Gln Arg Gln Ile His Leu Gly Ser 
        195                 200                 205             


Val Glu Ile Phe Thr His Asn Glu Met Val Asp Val Ile Val Thr Glu 
    210                 215                 220                 


Arg Asn Gly Glu Lys Arg Cys Glu Gly Leu Ile Met Arg Asn Leu Ile 
225                 230                 235                 240 


Thr Gly Glu Leu Thr Ala His Thr Gly His Ala Val Ile Leu Ala Thr 
                245                 250                 255     


Gly Gly Tyr Gly Asn Val Tyr His Met Ser Thr Leu Ala Lys Asn Ser 
            260                 265                 270         


Asn Ala Ser Ala Ile Met Arg Ala Tyr Glu Ala Gly Ala Tyr Phe Ala 
        275                 280                 285             


Ser Pro Ser Phe Ile Gln Phe His Pro Thr Gly Leu Pro Val Asn Ser 
    290                 295                 300                 


Thr Trp Gln Ser Lys Thr Ile Leu Met Ser Glu Ser Leu Arg Asn Asp 
305                 310                 315                 320 


Gly Arg Ile Trp Ser Pro Lys Glu Pro Asn Asp Asn Arg Asp Pro Asn 
                325                 330                 335     


Thr Ile Pro Glu Asp Glu Arg Asp Tyr Phe Leu Glu Arg Arg Tyr Pro 
            340                 345                 350         


Ala Phe Gly Asn Leu Val Pro Arg Asp Val Ala Ser Arg Ala Ile Ser 
        355                 360                 365             


Gln Gln Ile Asn Ala Gly Leu Gly Val Gly Pro Leu Asn Asn Ala Ala 
    370                 375                 380                 


Tyr Leu Asp Phe Arg Asp Ala Thr Glu Arg Leu Gly Gln Asp Thr Ile 
385                 390                 395                 400 


Arg Glu Arg Tyr Ser Asn Leu Phe Thr Met Tyr Glu Glu Ala Ile Gly 
                405                 410                 415     


Glu Asp Pro Tyr Ser Ser Pro Met Arg Ile Ala Pro Thr Cys His Phe 
            420                 425                 430         


Thr Met Gly Gly Leu Trp Thr Asp Phe Asn Glu Met Thr Ser Leu Pro 
        435                 440                 445             


Gly Leu Phe Cys Ala Gly Glu Ala Ser Trp Thr Tyr His Gly Ala Asn 
    450                 455                 460                 


Arg Leu Gly Ala Asn Ser Leu Leu Ser Ala Ser Val Asp Gly Trp Phe 
465                 470                 475                 480 


Thr Leu Pro Phe Thr Ile Pro Asn Tyr Leu Gly Pro Leu Leu Gly Ser 
                485                 490                 495     


Glu Arg Leu Ser Glu Asp Ala Pro Glu Ala Gln Ala Ala Ile Ala Arg 
            500                 505                 510         


Ala Gln Ala Arg Ile Asp Arg Leu Met Gly Asn Arg Pro Glu Trp Val 
        515                 520                 525             


Gly Asp Asn Val His Gly Pro Glu Tyr Tyr His Arg Gln Leu Gly Asp 
    530                 535                 540                 


Ile Leu Tyr Phe Ser Cys Gly Val Ser Arg Asn Val Glu Asp Leu Gln 
545                 550                 555                 560 


Asp Gly Ile Asn Lys Ile Arg Ala Leu Arg Asp Asp Phe Trp Lys Asn 
                565                 570                 575     


Met Arg Ile Thr Gly Ser Thr Asp Glu Met Asn Gln Val Leu Glu Tyr 
            580                 585                 590         


Ala Ala Arg Val Ala Asp Tyr Ile Asp Leu Gly Glu Leu Met Cys Val 
        595                 600                 605             


Asp Ala Leu Asp Arg Asp Glu Ser Cys Gly Ala His Phe Arg Asp Asp 
    610                 615                 620                 


His Leu Ser Glu Asp Gly Glu Ala Glu Arg Asp Asp Glu Asn Trp Cys 
625                 630                 635                 640 


Phe Val Ser Ala Trp Glu Pro Gly Glu Asn Gly Thr Phe Val Arg His 
                645                 650                 655     


Ala Glu Pro Leu Phe Phe Glu Ser Val Pro Leu Gln Thr Arg Asn Tyr 
            660                 665                 670         


Lys 
    


<210>  11
<211>  673
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  11

Met Ser Thr His Ser Glu Thr Thr Arg Pro Glu Phe Ile His Pro Val 
1               5                   10                  15      


Ser Val Leu Pro Glu Val Ser Ala Gly Thr Val Leu Asp Ala Ala Glu 
            20                  25                  30          


Pro Ala Gly Val Pro Thr Lys Asp Met Trp Glu Tyr Gln Lys Asp His 
        35                  40                  45              


Met Asn Leu Val Ser Pro Leu Asn Arg Arg Lys Phe Arg Val Leu Val 
    50                  55                  60                  


Val Gly Thr Gly Leu Ser Gly Gly Ala Ala Ala Ala Ala Leu Gly Glu 
65                  70                  75                  80  


Leu Gly Tyr Asp Val Lys Ala Phe Thr Tyr His Asp Ala Pro Arg Arg 
                85                  90                  95      


Ala His Ser Ile Ala Ala Gln Gly Gly Val Asn Ser Ala Arg Gly Lys 
            100                 105                 110         


Lys Val Asp Asn Asp Gly Ala Tyr Arg His Val Lys Asp Thr Val Lys 
        115                 120                 125             


Gly Gly Asp Tyr Arg Gly Arg Glu Ser Asp Cys Trp Arg Leu Ala Val 
    130                 135                 140                 


Glu Ser Val Arg Val Ile Asp His Met Asn Ala Ile Gly Ala Pro Phe 
145                 150                 155                 160 


Ala Arg Glu Tyr Gly Gly Ala Leu Ala Thr Arg Ser Phe Gly Gly Val 
                165                 170                 175     


Gln Val Ser Arg Thr Tyr Tyr Thr Arg Gly Gln Thr Gly Gln Gln Leu 
            180                 185                 190         


Gln Leu Ser Thr Ala Ser Ala Leu Gln Arg Gln Ile His Leu Gly Ser 
        195                 200                 205             


Val Glu Ile Phe Thr His Asn Glu Met Val Asp Val Ile Val Thr Glu 
    210                 215                 220                 


Arg Asn Gly Glu Lys Arg Cys Glu Gly Leu Ile Met Arg Asn Leu Ile 
225                 230                 235                 240 


Thr Gly Glu Leu Thr Ala His Thr Gly His Ala Val Ile Leu Ala Thr 
                245                 250                 255     


Gly Gly Tyr Gly Asn Val Tyr His Met Ser Thr Leu Ala Lys Asn Ser 
            260                 265                 270         


Asn Ala Ser Ala Ile Met Arg Ala Tyr Glu Ala Gly Ala Tyr Phe Ala 
        275                 280                 285             


Ser Pro Ser Phe Ile Gln Phe His Pro Thr Gly Leu Pro Val Asn Ser 
    290                 295                 300                 


Thr Trp Gln Ser Lys Thr Ile Leu Met Ser Glu Ser Leu Arg Asn Asp 
305                 310                 315                 320 


Gly Arg Ile Trp Ser Pro Lys Glu Pro Asn Asp Asn Arg Asp Pro Asn 
                325                 330                 335     


Thr Ile Pro Glu Asp Glu Arg Asp Tyr Phe Leu Glu Arg Arg Tyr Pro 
            340                 345                 350         


Ala Phe Gly Asn Leu Val Pro Arg Asp Val Ala Ser Arg Ala Ile Ser 
        355                 360                 365             


Gln Gln Ile Asn Ala Gly Leu Gly Val Gly Pro Leu Asn Asn Ala Ala 
    370                 375                 380                 


Tyr Leu Asp Phe Arg Asp Ala Thr Glu Arg Leu Gly Gln Asp Thr Ile 
385                 390                 395                 400 


Arg Glu Arg Tyr Ser Asn Leu Phe Thr Met Tyr Glu Glu Ala Ile Gly 
                405                 410                 415     


Glu Asp Pro Tyr Ser Ser Pro Met Arg Ile Ala Pro Thr Cys His Phe 
            420                 425                 430         


Thr Met Gly Gly Leu Trp Thr Asp Phe Asn Glu Met Thr Ser Leu Pro 
        435                 440                 445             


Gly Leu Phe Cys Ala Gly Glu Ala Ser Trp Thr Tyr His Gly Ala Asn 
    450                 455                 460                 


Arg Leu Gly Ala Asn Ser Leu Leu Ser Ala Ser Val Asp Gly Trp Phe 
465                 470                 475                 480 


Thr Leu Pro Phe Thr Ile Pro Asn Tyr Leu Gly Pro Leu Leu Gly Ser 
                485                 490                 495     


Glu Arg Leu Ser Glu Asp Ala Pro Glu Ala Gln Ala Ala Ile Ala Arg 
            500                 505                 510         


Ala Gln Ala Arg Ile Asp Arg Leu Met Gly Asn Arg Pro Glu Trp Val 
        515                 520                 525             


Gly Asp Asn Val His Gly Pro Glu Tyr Tyr His Arg Gln Leu Gly Asp 
    530                 535                 540                 


Ile Leu Tyr Phe Ser Cys Gly Val Ser Arg Asn Val Glu Asp Leu Gln 
545                 550                 555                 560 


Asp Gly Ile Asn Lys Ile Arg Ala Leu Arg Asp Asp Phe Trp Lys Asn 
                565                 570                 575     


Met Arg Ile Thr Gly Ser Thr Asp Glu Met Asn Gln Val Leu Glu Tyr 
            580                 585                 590         


Ala Ala Arg Val Ala Asp Tyr Ile Asp Leu Gly Glu Leu Met Cys Val 
        595                 600                 605             


Asp Ala Leu Asp Arg Asp Glu Ser Cys Gly Ala His Phe Arg Asp Asp 
    610                 615                 620                 


His Leu Ser Glu Asp Gly Glu Ala Glu Arg Asp Asp Glu Asn Trp Cys 
625                 630                 635                 640 


Phe Val Ser Ala Trp Glu Pro Gly Glu Asn Gly Thr Phe Val Arg His 
                645                 650                 655     


Ala Glu Pro Leu Phe Phe Glu Ser Val Pro Leu Gln Thr Arg Asn Tyr 
            660                 665                 670         


Lys 
    


<210>  12
<211>  883
<212>  PRT
<213>  Escherichia coli

<400>  12

Met Asn Glu Gln Tyr Ser Ala Leu Arg Ser Asn Val Ser Met Leu Gly 
1               5                   10                  15      


Lys Val Leu Gly Glu Thr Ile Lys Asp Ala Leu Gly Glu His Ile Leu 
            20                  25                  30          


Glu Arg Val Glu Thr Ile Arg Lys Leu Ser Lys Ser Ser Arg Ala Gly 
        35                  40                  45              


Asn Asp Ala Asn Arg Gln Glu Leu Leu Thr Thr Leu Gln Asn Leu Ser 
    50                  55                  60                  


Asn Asp Glu Leu Leu Pro Val Ala Arg Ala Phe Ser Gln Phe Leu Asn 
65                  70                  75                  80  


Leu Ala Asn Thr Ala Glu Gln Tyr His Ser Ile Ser Pro Lys Gly Glu 
                85                  90                  95      


Ala Ala Ser Asn Pro Glu Val Ile Ala Arg Thr Leu Arg Lys Leu Lys 
            100                 105                 110         


Asn Gln Pro Glu Leu Ser Glu Asp Thr Ile Lys Lys Ala Val Glu Ser 
        115                 120                 125             


Leu Ser Leu Glu Leu Val Leu Thr Ala His Pro Thr Glu Ile Thr Arg 
    130                 135                 140                 


Arg Thr Leu Ile His Lys Met Val Glu Val Asn Ala Cys Leu Lys Gln 
145                 150                 155                 160 


Leu Asp Asn Lys Asp Ile Ala Asp Tyr Glu His Asn Gln Leu Met Arg 
                165                 170                 175     


Arg Leu Arg Gln Leu Ile Ala Gln Ser Trp His Thr Asp Glu Ile Arg 
            180                 185                 190         


Lys Leu Arg Pro Ser Pro Val Asp Glu Ala Lys Trp Gly Phe Ala Val 
        195                 200                 205             


Val Glu Asn Ser Leu Trp Gln Gly Val Pro Asn Tyr Leu Arg Glu Leu 
    210                 215                 220                 


Asn Glu Gln Leu Glu Glu Asn Leu Gly Tyr Lys Leu Pro Val Glu Phe 
225                 230                 235                 240 


Val Pro Val Arg Phe Thr Ser Trp Met Gly Gly Asp Arg Asp Gly Asn 
                245                 250                 255     


Pro Asn Val Thr Ala Asp Ile Thr Arg His Val Leu Leu Leu Ser Arg 
            260                 265                 270         


Trp Lys Ala Thr Asp Leu Phe Leu Lys Asp Ile Gln Val Leu Val Ser 
        275                 280                 285             


Glu Leu Ser Met Val Glu Ala Thr Pro Glu Leu Leu Ala Leu Val Gly 
    290                 295                 300                 


Glu Glu Gly Ala Ala Glu Pro Tyr Arg Tyr Leu Met Lys Asn Leu Arg 
305                 310                 315                 320 


Ser Arg Leu Met Ala Thr Gln Ala Trp Leu Glu Ala Arg Leu Lys Gly 
                325                 330                 335     


Glu Glu Leu Pro Lys Pro Glu Gly Leu Leu Thr Gln Asn Glu Glu Leu 
            340                 345                 350         


Trp Glu Pro Leu Tyr Ala Cys Tyr Gln Ser Leu Gln Ala Cys Gly Met 
        355                 360                 365             


Gly Ile Ile Ala Asn Gly Asp Leu Leu Asp Thr Leu Arg Arg Val Lys 
    370                 375                 380                 


Cys Phe Gly Val Pro Leu Val Arg Ile Asp Ile Arg Gln Glu Ser Thr 
385                 390                 395                 400 


Arg His Thr Glu Ala Leu Gly Glu Leu Thr Arg Tyr Leu Gly Ile Gly 
                405                 410                 415     


Asp Tyr Glu Ser Trp Ser Glu Ala Asp Lys Gln Ala Phe Leu Ile Arg 
            420                 425                 430         


Glu Leu Asn Ser Lys Arg Pro Leu Leu Pro Arg Asn Trp Gln Pro Ser 
        435                 440                 445             


Ala Glu Thr Arg Glu Val Leu Asp Thr Cys Gln Val Ile Ala Glu Ala 
    450                 455                 460                 


Pro Gln Gly Ser Ile Ala Ala Tyr Val Ile Ser Met Ala Lys Thr Pro 
465                 470                 475                 480 


Ser Asp Val Leu Ala Val His Leu Leu Leu Lys Glu Ala Gly Ile Gly 
                485                 490                 495     


Phe Ala Met Pro Val Ala Pro Leu Phe Glu Thr Leu Asp Asp Leu Asn 
            500                 505                 510         


Asn Ala Asn Asp Val Met Thr Gln Leu Leu Asn Ile Asp Trp Tyr Arg 
        515                 520                 525             


Gly Leu Ile Gln Gly Lys Gln Met Val Met Ile Gly Tyr Ser Asp Ser 
    530                 535                 540                 


Ala Lys Asp Ala Gly Val Met Ala Ala Ser Trp Ala Gln Tyr Gln Ala 
545                 550                 555                 560 


Gln Asp Ala Leu Ile Lys Thr Cys Glu Lys Ala Gly Ile Glu Leu Thr 
                565                 570                 575     


Leu Phe His Gly Arg Gly Gly Ser Ile Gly Arg Gly Gly Ala Pro Ala 
            580                 585                 590         


His Ala Ala Leu Leu Ser Gln Pro Pro Gly Ser Leu Lys Gly Gly Leu 
        595                 600                 605             


Arg Val Thr Glu Gln Gly Glu Met Ile Arg Phe Lys Tyr Gly Leu Pro 
    610                 615                 620                 


Glu Ile Thr Val Ser Ser Leu Ser Leu Tyr Thr Gly Ala Ile Leu Glu 
625                 630                 635                 640 


Ala Asn Leu Leu Pro Pro Pro Glu Pro Lys Glu Ser Trp Arg Arg Ile 
                645                 650                 655     


Met Asp Glu Leu Ser Val Ile Ser Cys Asp Val Tyr Arg Gly Tyr Val 
            660                 665                 670         


Arg Glu Asn Lys Asp Phe Val Pro Tyr Phe Arg Ser Ala Thr Pro Glu 
        675                 680                 685             


Gln Glu Leu Gly Lys Leu Pro Leu Gly Ser Arg Pro Ala Lys Arg Arg 
    690                 695                 700                 


Pro Thr Gly Gly Val Glu Ser Leu Arg Ala Ile Pro Trp Ile Phe Ala 
705                 710                 715                 720 


Trp Thr Gln Asn Arg Leu Met Leu Pro Ala Trp Leu Gly Ala Gly Thr 
                725                 730                 735     


Ala Leu Gln Lys Val Val Glu Asp Gly Lys Gln Ser Glu Leu Glu Ala 
            740                 745                 750         


Met Cys Arg Asp Trp Pro Phe Phe Ser Thr Arg Leu Gly Met Leu Glu 
        755                 760                 765             


Met Val Phe Ala Lys Ala Asp Leu Trp Leu Ala Glu Tyr Tyr Asp Gln 
    770                 775                 780                 


Arg Leu Val Asp Lys Ala Leu Trp Pro Leu Gly Lys Glu Leu Arg Asn 
785                 790                 795                 800 


Leu Gln Glu Glu Asp Ile Lys Val Val Leu Ala Ile Ala Asn Asp Ser 
                805                 810                 815     


His Leu Met Ala Asp Leu Pro Trp Ile Ala Glu Ser Ile Gln Leu Arg 
            820                 825                 830         


Asn Ile Tyr Thr Asp Pro Leu Asn Val Leu Gln Ala Glu Leu Leu His 
        835                 840                 845             


Arg Ser Arg Gln Ala Glu Lys Glu Gly Gln Glu Pro Asp Pro Arg Val 
    850                 855                 860                 


Glu Gln Ala Leu Met Val Thr Ile Ala Gly Ile Ala Ala Gly Met Arg 
865                 870                 875                 880 


Asn Thr Gly 
            


<210>  13
<211>  606
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  13

Met Thr Ser Ala Thr Ile Pro Gly Leu Asp Thr Ala Pro Thr Asn His 
1               5                   10                  15      


Gln Gly Leu Leu Ser Trp Val Glu Glu Val Ala Glu Leu Thr Gln Pro 
            20                  25                  30          


Asp Arg Val Val Phe Thr Asp Gly Ser Glu Glu Glu Phe Gln Arg Leu 
        35                  40                  45              


Cys Asp Gln Leu Val Glu Ala Gly Thr Phe Ile Arg Leu Asn Pro Glu 
    50                  55                  60                  


Lys His Lys Asn Ser Tyr Leu Ala Leu Ser Asp Pro Ser Asp Val Ala 
65                  70                  75                  80  


Arg Val Glu Ser Arg Thr Tyr Ile Cys Ser Ala Lys Glu Ile Asp Ala 
                85                  90                  95      


Gly Pro Thr Asn Asn Trp Met Asp Pro Gly Glu Met Arg Ser Ile Met 
            100                 105                 110         


Lys Asp Leu Tyr Arg Gly Cys Met Arg Gly Arg Thr Met Tyr Val Val 
        115                 120                 125             


Pro Phe Cys Met Gly Pro Leu Gly Ala Glu Asp Pro Lys Leu Gly Val 
    130                 135                 140                 


Glu Ile Thr Asp Ser Glu Tyr Val Val Val Ser Met Arg Thr Met Thr 
145                 150                 155                 160 


Arg Met Gly Lys Ala Ala Leu Glu Lys Met Gly Asp Asp Gly Phe Phe 
                165                 170                 175     


Val Lys Ala Leu His Ser Val Gly Ala Pro Leu Glu Pro Gly Gln Lys 
            180                 185                 190         


Asp Val Ala Trp Pro Cys Ser Glu Thr Lys Tyr Ile Thr His Phe Pro 
        195                 200                 205             


Glu Thr Arg Glu Ile Trp Ser Tyr Gly Ser Gly Tyr Gly Gly Asn Ala 
    210                 215                 220                 


Leu Leu Gly Lys Lys Cys Tyr Ser Leu Arg Ile Ala Ser Ala Met Ala 
225                 230                 235                 240 


His Asp Glu Gly Trp Leu Ala Glu His Met Leu Ile Leu Lys Leu Ile 
                245                 250                 255     


Ser Pro Glu Asn Lys Ala Tyr Tyr Phe Ala Ala Ala Phe Pro Ser Ala 
            260                 265                 270         


Cys Gly Lys Thr Asn Leu Ala Met Leu Gln Pro Thr Ile Pro Gly Trp 
        275                 280                 285             


Arg Ala Glu Thr Leu Gly Asp Asp Ile Ala Trp Met Arg Phe Gly Lys 
    290                 295                 300                 


Asp Gly Arg Leu Tyr Ala Val Asn Pro Glu Phe Gly Phe Phe Gly Val 
305                 310                 315                 320 


Ala Pro Gly Thr Asn Trp Lys Ser Asn Pro Asn Ala Met Arg Thr Ile 
                325                 330                 335     


Ala Ala Gly Asn Thr Val Phe Thr Asn Val Ala Leu Thr Asp Asp Gly 
            340                 345                 350         


Asp Val Trp Trp Glu Gly Leu Glu Gly Asp Pro Gln His Leu Ile Asp 
        355                 360                 365             


Trp Lys Gly Asn Asp Trp Tyr Phe Arg Glu Thr Glu Thr Asn Ala Ala 
    370                 375                 380                 


His Pro Asn Ser Arg Tyr Cys Thr Pro Met Ser Gln Cys Pro Ile Leu 
385                 390                 395                 400 


Ala Pro Glu Trp Asp Asp Pro Gln Gly Val Pro Ile Ser Gly Ile Leu 
                405                 410                 415     


Phe Gly Gly Arg Arg Lys Thr Thr Val Pro Leu Val Thr Glu Ala Arg 
            420                 425                 430         


Asp Trp Gln His Gly Val Phe Ile Gly Ala Thr Leu Gly Ser Glu Gln 
        435                 440                 445             


Thr Ala Ala Ala Glu Gly Lys Val Gly Asn Val Arg Arg Asp Pro Met 
    450                 455                 460                 


Ala Met Leu Pro Phe Leu Gly Tyr Asn Val Gly Asp Tyr Phe Gln His 
465                 470                 475                 480 


Trp Ile Asn Leu Gly Lys His Ala Asp Glu Ser Lys Leu Pro Lys Val 
                485                 490                 495     


Phe Phe Val Asn Trp Phe Arg Arg Gly Asp Asp Gly Arg Phe Leu Trp 
            500                 505                 510         


Pro Gly Phe Gly Glu Asn Ser Arg Val Leu Lys Trp Ile Val Asp Arg 
        515                 520                 525             


Ile Glu His Lys Ala Gly Gly Ala Thr Thr Pro Ile Gly Thr Val Pro 
    530                 535                 540                 


Ala Val Glu Asp Leu Asp Leu Asp Gly Leu Asp Val Asp Ala Ala Asp 
545                 550                 555                 560 


Val Ala Ala Ala Leu Ala Val Asp Ala Asp Glu Trp Arg Gln Glu Leu 
                565                 570                 575     


Pro Leu Ile Glu Glu Trp Leu Gln Phe Val Gly Glu Lys Leu Pro Thr 
            580                 585                 590         


Gly Val Lys Asp Glu Phe Asp Ala Leu Lys Glu Arg Leu Gly 
        595                 600                 605     


<210>  14
<211>  919
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  14

Met Thr Asp Phe Leu Arg Asp Asp Ile Arg Phe Leu Gly Gln Ile Leu 
1               5                   10                  15      


Gly Glu Val Ile Ala Glu Gln Glu Gly Gln Glu Val Tyr Glu Leu Val 
            20                  25                  30          


Glu Gln Ala Arg Leu Thr Ser Phe Asp Ile Ala Lys Gly Asn Ala Glu 
        35                  40                  45              


Met Asp Ser Leu Val Gln Val Phe Asp Gly Ile Thr Pro Ala Lys Ala 
    50                  55                  60                  


Thr Pro Ile Ala Arg Ala Phe Ser His Phe Ala Leu Leu Ala Asn Leu 
65                  70                  75                  80  


Ala Glu Asp Leu Tyr Asp Glu Glu Leu Arg Glu Gln Ala Leu Asp Ala 
                85                  90                  95      


Gly Asp Thr Pro Pro Asp Ser Thr Leu Asp Ala Thr Trp Leu Lys Leu 
            100                 105                 110         


Asn Glu Gly Asn Val Gly Ala Glu Ala Val Ala Asp Val Leu Arg Asn 
        115                 120                 125             


Ala Glu Val Ala Pro Val Leu Thr Ala His Pro Thr Glu Thr Arg Arg 
    130                 135                 140                 


Arg Thr Val Phe Asp Ala Gln Lys Trp Ile Thr Thr His Met Arg Glu 
145                 150                 155                 160 


Arg His Ala Leu Gln Ser Ala Glu Pro Thr Ala Arg Thr Gln Ser Lys 
                165                 170                 175     


Leu Asp Glu Ile Glu Lys Asn Ile Arg Arg Arg Ile Thr Ile Leu Trp 
            180                 185                 190         


Gln Thr Ala Leu Ile Arg Val Ala Arg Pro Arg Ile Glu Asp Glu Ile 
        195                 200                 205             


Glu Val Gly Leu Arg Tyr Tyr Lys Leu Ser Leu Leu Glu Glu Ile Pro 
    210                 215                 220                 


Arg Ile Asn Arg Asp Val Ala Val Glu Leu Arg Glu Arg Phe Gly Glu 
225                 230                 235                 240 


Gly Val Pro Leu Lys Pro Val Val Lys Pro Gly Ser Trp Ile Gly Gly 
                245                 250                 255     


Asp His Asp Gly Asn Pro Tyr Val Thr Ala Glu Thr Val Glu Tyr Ser 
            260                 265                 270         


Thr His Arg Ala Ala Glu Thr Val Leu Lys Tyr Tyr Ala Arg Gln Leu 
        275                 280                 285             


His Ser Leu Glu His Glu Leu Ser Leu Ser Asp Arg Met Asn Lys Val 
    290                 295                 300                 


Thr Pro Gln Leu Leu Ala Leu Ala Asp Ala Gly His Asn Asp Val Pro 
305                 310                 315                 320 


Ser Arg Val Asp Glu Pro Tyr Arg Arg Ala Val His Gly Val Arg Gly 
                325                 330                 335     


Arg Ile Leu Ala Thr Thr Ala Glu Leu Ile Gly Glu Asp Ala Val Glu 
            340                 345                 350         


Gly Val Trp Phe Lys Val Phe Thr Pro Tyr Ala Ser Pro Glu Glu Phe 
        355                 360                 365             


Leu Asn Asp Ala Leu Thr Ile Asp His Ser Leu Arg Glu Ser Lys Asp 
    370                 375                 380                 


Val Leu Ile Ala Asp Asp Arg Leu Ser Val Leu Ile Ser Ala Ile Glu 
385                 390                 395                 400 


Ser Phe Gly Phe Asn Leu Tyr Ala Leu Asp Leu Arg Gln Asn Ser Glu 
                405                 410                 415     


Ser Tyr Glu Asp Val Leu Thr Glu Leu Phe Glu Arg Ala Gln Val Thr 
            420                 425                 430         


Ala Asn Tyr Arg Glu Leu Ser Glu Ala Glu Lys Leu Glu Val Leu Leu 
        435                 440                 445             


Lys Glu Leu Arg Ser Pro Arg Pro Leu Ile Pro His Gly Ser Asp Glu 
    450                 455                 460                 


Tyr Ser Glu Val Thr Asp Arg Glu Leu Gly Ile Phe Arg Thr Ala Ser 
465                 470                 475                 480 


Glu Ala Val Lys Lys Phe Gly Pro Arg Met Val Pro His Cys Ile Ile 
                485                 490                 495     


Ser Met Ala Ser Ser Val Thr Asp Val Leu Glu Pro Met Val Leu Leu 
            500                 505                 510         


Lys Glu Phe Gly Leu Ile Ala Ala Asn Gly Asp Asn Pro Arg Gly Thr 
        515                 520                 525             


Val Asp Val Ile Pro Leu Phe Glu Thr Ile Glu Asp Leu Gln Ala Gly 
    530                 535                 540                 


Ala Gly Ile Leu Asp Glu Leu Trp Lys Ile Asp Leu Tyr Arg Asn Tyr 
545                 550                 555                 560 


Leu Leu Gln Arg Asp Asn Val Gln Glu Val Met Leu Gly Tyr Ser Asp 
                565                 570                 575     


Ser Asn Lys Asp Gly Gly Tyr Phe Ser Ala Asn Trp Ala Leu Tyr Asp 
            580                 585                 590         


Ala Glu Leu Gln Leu Val Glu Leu Cys Arg Ser Ala Gly Val Lys Leu 
        595                 600                 605             


Arg Leu Phe His Gly Arg Gly Gly Thr Val Gly Arg Gly Gly Gly Pro 
    610                 615                 620                 


Ser Tyr Asp Ala Ile Leu Ala Gln Pro Arg Gly Ala Val Gln Gly Ser 
625                 630                 635                 640 


Val Arg Ile Thr Glu Gln Gly Glu Ile Ile Ser Ala Lys Tyr Gly Asn 
                645                 650                 655     


Pro Glu Thr Ala Arg Arg Asn Leu Glu Ala Leu Val Ser Ala Thr Leu 
            660                 665                 670         


Glu Ala Ser Leu Leu Asp Val Ser Glu Leu Thr Asp His Gln Arg Ala 
        675                 680                 685             


Tyr Asp Ile Met Ser Glu Ile Ser Glu Leu Ser Leu Lys Lys Tyr Ala 
    690                 695                 700                 


Ser Leu Val His Glu Asp Gln Gly Phe Ile Asp Tyr Phe Thr Gln Ser 
705                 710                 715                 720 


Thr Pro Leu Gln Glu Ile Gly Ser Leu Asn Ile Gly Ser Arg Pro Ser 
                725                 730                 735     


Ser Arg Lys Gln Thr Ser Ser Val Glu Asp Leu Arg Ala Ile Pro Trp 
            740                 745                 750         


Val Leu Ser Trp Ser Gln Ser Arg Val Met Leu Pro Gly Trp Phe Gly 
        755                 760                 765             


Val Gly Thr Ala Leu Glu Gln Trp Ile Gly Glu Gly Glu Gln Ala Thr 
    770                 775                 780                 


Gln Arg Ile Ala Glu Leu Gln Thr Leu Asn Glu Ser Trp Pro Phe Phe 
785                 790                 795                 800 


Thr Ser Val Leu Asp Asn Met Ala Gln Val Met Ser Lys Ala Glu Leu 
                805                 810                 815     


Arg Leu Ala Lys Leu Tyr Ala Asp Leu Ile Pro Asp Thr Glu Val Ala 
            820                 825                 830         


Glu Arg Val Tyr Ser Val Ile Arg Glu Glu Tyr Phe Leu Thr Lys Lys 
        835                 840                 845             


Met Phe Cys Val Ile Thr Gly Ser Asp Asp Leu Leu Asp Asp Asn Pro 
    850                 855                 860                 


Leu Leu Ala Arg Ser Val Gln Arg Arg Tyr Pro Tyr Leu Leu Pro Leu 
865                 870                 875                 880 


Asn Val Ile Gln Val Glu Met Met Arg Arg Tyr Arg Lys Gly Asp Gln 
                885                 890                 895     


Ser Glu Gln Val Ser Arg Asn Ile Gln Leu Thr Met Asn Gly Leu Ser 
            900                 905                 910         


Thr Ala Leu Arg Asn Ser Gly 
        915                 


<210>  15
<211>  1140
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  15

Met Ser Thr His Thr Ser Ser Thr Leu Pro Ala Phe Lys Lys Ile Leu 
1               5                   10                  15      


Val Ala Asn Arg Gly Glu Ile Ala Val Arg Ala Phe Arg Ala Ala Leu 
            20                  25                  30          


Glu Thr Gly Ala Ala Thr Val Ala Ile Tyr Pro Arg Glu Asp Arg Gly 
        35                  40                  45              


Ser Phe His Arg Ser Phe Ala Ser Glu Ala Val Arg Ile Gly Thr Glu 
    50                  55                  60                  


Gly Ser Pro Val Lys Ala Tyr Leu Asp Ile Asp Glu Ile Ile Gly Ala 
65                  70                  75                  80  


Ala Lys Lys Val Lys Ala Asp Ala Ile Tyr Pro Gly Tyr Gly Phe Leu 
                85                  90                  95      


Ser Glu Asn Ala Gln Leu Ala Arg Glu Cys Ala Glu Asn Gly Ile Thr 
            100                 105                 110         


Phe Ile Gly Pro Thr Pro Glu Val Leu Asp Leu Thr Gly Asp Lys Ser 
        115                 120                 125             


Arg Ala Val Thr Ala Ala Lys Lys Ala Gly Leu Pro Val Leu Ala Glu 
    130                 135                 140                 


Ser Thr Pro Ser Lys Asn Ile Asp Glu Ile Val Lys Ser Ala Glu Gly 
145                 150                 155                 160 


Gln Thr Tyr Pro Ile Phe Val Lys Ala Val Ala Gly Gly Gly Gly Arg 
                165                 170                 175     


Gly Met Arg Phe Val Ala Ser Pro Asp Glu Leu Arg Lys Leu Ala Thr 
            180                 185                 190         


Glu Ala Ser Arg Glu Ala Glu Ala Ala Phe Gly Asp Gly Ala Val Tyr 
        195                 200                 205             


Val Glu Arg Ala Val Ile Asn Pro Gln His Ile Glu Val Gln Ile Leu 
    210                 215                 220                 


Gly Asp His Thr Gly Glu Val Val His Leu Tyr Glu Arg Asp Cys Ser 
225                 230                 235                 240 


Leu Gln Arg Arg His Gln Lys Val Val Glu Ile Ala Pro Ala Gln His 
                245                 250                 255     


Leu Asp Pro Glu Leu Arg Asp Arg Ile Cys Ala Asp Ala Val Lys Phe 
            260                 265                 270         


Cys Arg Ser Ile Gly Tyr Gln Gly Ala Gly Thr Val Glu Phe Leu Val 
        275                 280                 285             


Asp Glu Lys Gly Asn His Val Phe Ile Glu Met Asn Pro Arg Ile Gln 
    290                 295                 300                 


Val Glu His Thr Val Thr Glu Glu Val Thr Glu Val Asp Leu Val Lys 
305                 310                 315                 320 


Ala Gln Met Arg Leu Ala Ala Gly Ala Thr Leu Lys Glu Leu Gly Leu 
                325                 330                 335     


Thr Gln Asp Lys Ile Lys Thr His Gly Ala Ala Leu Gln Cys Arg Ile 
            340                 345                 350         


Thr Thr Glu Asp Pro Asn Asn Gly Phe Arg Pro Asp Thr Gly Thr Ile 
        355                 360                 365             


Thr Ala Tyr Arg Ser Pro Gly Gly Ala Gly Val Arg Leu Asp Gly Ala 
    370                 375                 380                 


Ala Gln Leu Gly Gly Glu Ile Thr Ala His Phe Asp Ser Met Leu Val 
385                 390                 395                 400 


Lys Met Thr Cys Arg Gly Ser Asp Phe Glu Thr Ala Val Ala Arg Ala 
                405                 410                 415     


Gln Arg Ala Leu Ala Glu Phe Thr Val Ser Gly Val Ala Thr Asn Ile 
            420                 425                 430         


Gly Phe Leu Arg Ala Leu Leu Arg Glu Glu Asp Phe Thr Ser Lys Arg 
        435                 440                 445             


Ile Ala Thr Gly Phe Ile Ala Asp His Pro His Leu Leu Gln Ala Pro 
    450                 455                 460                 


Pro Ala Asp Asp Glu Gln Gly Arg Ile Leu Asp Tyr Leu Ala Asp Val 
465                 470                 475                 480 


Thr Val Asn Lys Pro His Gly Val Arg Pro Lys Asp Val Ala Ala Pro 
                485                 490                 495     


Ile Asp Lys Leu Pro Asn Ile Lys Asp Leu Pro Leu Pro Arg Gly Ser 
            500                 505                 510         


Arg Asp Arg Leu Lys Gln Leu Gly Pro Ala Ala Phe Ala Arg Asp Leu 
        515                 520                 525             


Arg Glu Gln Asp Ala Leu Ala Val Thr Asp Thr Thr Phe Arg Asp Ala 
    530                 535                 540                 


His Gln Ser Leu Leu Ala Thr Arg Val Arg Ser Phe Ala Leu Lys Pro 
545                 550                 555                 560 


Ala Ala Glu Ala Val Ala Lys Leu Thr Pro Glu Leu Leu Ser Val Glu 
                565                 570                 575     


Ala Trp Gly Gly Ala Thr Tyr Asp Val Ala Met Arg Phe Leu Phe Glu 
            580                 585                 590         


Asp Pro Trp Asp Arg Leu Asp Glu Leu Arg Glu Ala Met Pro Asn Val 
        595                 600                 605             


Asn Ile Gln Met Leu Leu Arg Gly Arg Asn Thr Val Gly Tyr Thr Pro 
    610                 615                 620                 


Tyr Pro Asp Ser Val Cys Arg Ala Phe Val Lys Glu Ala Ala Ser Ser 
625                 630                 635                 640 


Gly Val Asp Ile Phe Arg Ile Phe Asp Ala Leu Asn Asp Val Ser Gln 
                645                 650                 655     


Met Arg Pro Ala Ile Asp Ala Val Leu Glu Thr Asn Thr Ala Val Ala 
            660                 665                 670         


Glu Val Ala Met Ala Tyr Ser Gly Asp Leu Ser Asp Pro Asn Glu Lys 
        675                 680                 685             


Leu Tyr Thr Leu Asp Tyr Tyr Leu Lys Met Ala Glu Glu Ile Val Lys 
    690                 695                 700                 


Ser Gly Ala His Ile Leu Ala Ile Lys Asp Met Ala Gly Leu Leu Arg 
705                 710                 715                 720 


Pro Ala Ala Val Thr Lys Leu Val Thr Ala Leu Arg Arg Glu Phe Asp 
                725                 730                 735     


Leu Pro Val His Val His Thr His Asp Thr Ala Gly Gly Gln Leu Ala 
            740                 745                 750         


Thr Tyr Phe Ala Ala Ala Gln Ala Gly Ala Asp Ala Val Asp Gly Ala 
        755                 760                 765             


Ser Ala Pro Leu Ser Gly Thr Thr Ser Gln Pro Ser Leu Ser Ala Ile 
    770                 775                 780                 


Val Ala Ala Phe Ala His Thr Arg Arg Asp Thr Gly Leu Ser Leu Glu 
785                 790                 795                 800 


Ala Val Ser Asp Leu Glu Pro Tyr Trp Glu Ala Val Arg Gly Leu Tyr 
                805                 810                 815     


Leu Pro Phe Glu Ser Gly Thr Pro Gly Pro Thr Gly Arg Val Tyr Arg 
            820                 825                 830         


His Glu Ile Pro Gly Gly Gln Leu Ser Asn Leu Arg Ala Gln Ala Thr 
        835                 840                 845             


Ala Leu Gly Leu Ala Asp Arg Phe Glu Leu Ile Glu Asp Asn Tyr Ala 
    850                 855                 860                 


Ala Val Asn Glu Met Leu Gly Arg Pro Thr Lys Val Thr Pro Ser Ser 
865                 870                 875                 880 


Lys Val Val Gly Asp Leu Ala Leu His Leu Val Gly Ala Gly Val Asp 
                885                 890                 895     


Pro Ala Asp Phe Ala Ala Asp Pro Gln Lys Tyr Asp Ile Pro Asp Ser 
            900                 905                 910         


Val Ile Ala Phe Leu Arg Gly Glu Leu Gly Asn Pro Pro Gly Gly Trp 
        915                 920                 925             


Pro Glu Pro Leu Arg Thr Arg Ala Leu Glu Gly Arg Ser Glu Gly Lys 
    930                 935                 940                 


Ala Pro Leu Thr Glu Val Pro Glu Glu Glu Gln Ala His Leu Asp Ala 
945                 950                 955                 960 


Asp Asp Ser Lys Glu Arg Arg Asn Ser Leu Asn Arg Leu Leu Phe Pro 
                965                 970                 975     


Lys Pro Thr Glu Glu Phe Leu Glu His Arg Arg Arg Phe Gly Asn Thr 
            980                 985                 990         


Ser Ala Leu Asp Asp Arg Glu Phe  Phe Tyr Gly Leu Val  Glu Gly Arg 
        995                 1000                 1005             


Glu Thr  Leu Ile Arg Leu Pro  Asp Val Arg Thr Pro  Leu Leu Val 
    1010                 1015                 1020             


Arg Leu  Asp Ala Ile Ser Glu  Pro Asp Asp Lys Gly  Met Arg Asn 
    1025                 1030                 1035             


Val Val  Ala Asn Val Asn Gly  Gln Ile Arg Pro Met  Arg Val Arg 
    1040                 1045                 1050             


Asp Arg  Ser Val Glu Ser Val  Thr Ala Thr Ala Glu  Lys Ala Asp 
    1055                 1060                 1065             


Ser Ser  Asn Lys Gly His Val  Ala Ala Pro Phe Ala  Gly Val Val 
    1070                 1075                 1080             


Thr Val  Thr Val Ala Glu Gly  Asp Glu Val Lys Ala  Gly Asp Ala 
    1085                 1090                 1095             


Val Ala  Ile Ile Glu Ala Met  Lys Met Glu Ala Thr  Ile Thr Ala 
    1100                 1105                 1110             


Ser Val  Asp Gly Lys Ile Asp  Arg Val Val Val Pro  Ala Ala Thr 
    1115                 1120                 1125             


Lys Val  Glu Gly Gly Asp Leu  Ile Val Val Val Ser  
    1130                 1135                 1140 


<210>  16
<211>  538
<212>  PRT
<213>  Actinobacillus succinogenes

<400>  16

Met Thr Asp Leu Asn Lys Leu Val Lys Glu Leu Asn Asp Leu Gly Leu 
1               5                   10                  15      


Thr Asp Val Lys Glu Ile Val Tyr Asn Pro Ser Tyr Glu Gln Leu Phe 
            20                  25                  30          


Glu Glu Glu Thr Lys Pro Gly Leu Glu Gly Phe Asp Lys Gly Thr Leu 
        35                  40                  45              


Thr Thr Leu Gly Ala Val Ala Val Asp Thr Gly Ile Phe Thr Gly Arg 
    50                  55                  60                  


Ser Pro Lys Asp Lys Tyr Ile Val Cys Asp Glu Thr Thr Lys Asp Thr 
65                  70                  75                  80  


Val Trp Trp Asn Ser Glu Ala Ala Lys Asn Asp Asn Lys Pro Met Thr 
                85                  90                  95      


Gln Glu Thr Trp Lys Ser Leu Arg Glu Leu Val Ala Lys Gln Leu Ser 
            100                 105                 110         


Gly Lys Arg Leu Phe Val Val Glu Gly Tyr Cys Gly Ala Ser Glu Lys 
        115                 120                 125             


His Arg Ile Gly Val Arg Met Val Thr Glu Val Ala Trp Gln Ala His 
    130                 135                 140                 


Phe Val Lys Asn Met Phe Ile Arg Pro Thr Asp Glu Glu Leu Lys Asn 
145                 150                 155                 160 


Phe Lys Ala Asp Phe Thr Val Leu Asn Gly Ala Lys Cys Thr Asn Pro 
                165                 170                 175     


Asn Trp Lys Glu Gln Gly Leu Asn Ser Glu Asn Phe Val Ala Phe Asn 
            180                 185                 190         


Ile Thr Glu Gly Ile Gln Leu Ile Gly Gly Thr Trp Tyr Gly Gly Glu 
        195                 200                 205             


Met Lys Lys Gly Met Phe Ser Met Met Asn Tyr Phe Leu Pro Leu Lys 
    210                 215                 220                 


Gly Val Ala Ser Met His Cys Ser Ala Asn Val Gly Lys Asp Gly Asp 
225                 230                 235                 240 


Val Ala Ile Phe Phe Gly Leu Ser Gly Thr Gly Lys Thr Thr Leu Ser 
                245                 250                 255     


Thr Asp Pro Lys Arg Gln Leu Ile Gly Asp Asp Glu His Gly Trp Asp 
            260                 265                 270         


Glu Ser Gly Val Phe Asn Phe Glu Gly Gly Cys Tyr Ala Lys Thr Ile 
        275                 280                 285             


Asn Leu Ser Gln Glu Asn Glu Pro Asp Ile Tyr Gly Ala Ile Arg Arg 
    290                 295                 300                 


Asp Ala Leu Leu Glu Asn Val Val Val Arg Ala Asp Gly Ser Val Asp 
305                 310                 315                 320 


Phe Asp Asp Gly Ser Lys Thr Glu Asn Thr Arg Val Ser Tyr Pro Ile 
                325                 330                 335     


Tyr His Ile Asp Asn Ile Val Arg Pro Val Ser Lys Ala Gly His Ala 
            340                 345                 350         


Thr Lys Val Ile Phe Leu Thr Ala Asp Ala Phe Gly Val Leu Pro Pro 
        355                 360                 365             


Val Ser Lys Leu Thr Pro Glu Gln Thr Glu Tyr Tyr Phe Leu Ser Gly 
    370                 375                 380                 


Phe Thr Ala Lys Leu Ala Gly Thr Glu Arg Gly Val Thr Glu Pro Thr 
385                 390                 395                 400 


Pro Thr Phe Ser Ala Cys Phe Gly Ala Ala Phe Leu Ser Leu His Pro 
                405                 410                 415     


Ile Gln Tyr Ala Asp Val Leu Val Glu Arg Met Lys Ala Ser Gly Ala 
            420                 425                 430         


Glu Ala Tyr Leu Val Asn Thr Gly Trp Asn Gly Thr Gly Lys Arg Ile 
        435                 440                 445             


Ser Ile Lys Asp Thr Arg Gly Ile Ile Asp Ala Ile Leu Asp Gly Ser 
    450                 455                 460                 


Ile Glu Lys Ala Glu Met Gly Glu Leu Pro Ile Phe Asn Leu Ala Ile 
465                 470                 475                 480 


Pro Lys Ala Leu Pro Gly Val Asp Pro Ala Ile Leu Asp Pro Arg Asp 
                485                 490                 495     


Thr Tyr Ala Asp Lys Ala Gln Trp Gln Val Lys Ala Glu Asp Leu Ala 
            500                 505                 510         


Asn Arg Phe Val Lys Asn Phe Val Lys Tyr Thr Ala Asn Pro Glu Ala 
        515                 520                 525             


Ala Lys Leu Val Gly Ala Gly Pro Lys Ala 
    530                 535             


<210>  17
<211>  610
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  17

Met Thr Thr Ala Ala Ile Arg Gly Leu Gln Gly Glu Ala Pro Thr Lys 
1               5                   10                  15      


Asn Lys Glu Leu Leu Asn Trp Ile Ala Asp Ala Val Glu Leu Phe Gln 
            20                  25                  30          


Pro Glu Ala Val Val Phe Val Asp Gly Ser Gln Ala Glu Trp Asp Arg 
        35                  40                  45              


Met Ala Glu Asp Leu Val Glu Ala Gly Thr Leu Ile Lys Leu Asn Glu 
    50                  55                  60                  


Glu Lys Arg Pro Asn Ser Tyr Leu Ala Arg Ser Asn Pro Ser Asp Val 
65                  70                  75                  80  


Ala Arg Val Glu Ser Arg Thr Phe Ile Cys Ser Glu Lys Glu Glu Asp 
                85                  90                  95      


Ala Gly Pro Thr Asn Asn Trp Ala Pro Pro Gln Ala Met Lys Asp Glu 
            100                 105                 110         


Met Ser Lys His Tyr Ala Gly Ser Met Lys Gly Arg Thr Met Tyr Val 
        115                 120                 125             


Val Pro Phe Cys Met Gly Pro Ile Ser Asp Pro Asp Pro Lys Leu Gly 
    130                 135                 140                 


Val Gln Leu Thr Asp Ser Glu Tyr Val Val Met Ser Met Arg Ile Met 
145                 150                 155                 160 


Thr Arg Met Gly Ile Glu Ala Leu Asp Lys Ile Gly Ala Asn Gly Ser 
                165                 170                 175     


Phe Val Arg Cys Leu His Ser Val Gly Ala Pro Leu Glu Pro Gly Gln 
            180                 185                 190         


Glu Asp Val Ala Trp Pro Cys Asn Asp Thr Lys Tyr Ile Thr Gln Phe 
        195                 200                 205             


Pro Glu Thr Lys Glu Ile Trp Ser Tyr Gly Ser Gly Tyr Gly Gly Asn 
    210                 215                 220                 


Ala Ile Leu Ala Lys Lys Cys Tyr Ala Leu Arg Ile Ala Ser Val Met 
225                 230                 235                 240 


Ala Arg Glu Glu Gly Trp Met Ala Glu His Met Leu Ile Leu Lys Leu 
                245                 250                 255     


Ile Asn Pro Glu Gly Lys Ala Tyr His Ile Ala Ala Ala Phe Pro Ser 
            260                 265                 270         


Ala Cys Gly Lys Thr Asn Leu Ala Met Ile Thr Pro Thr Ile Pro Gly 
        275                 280                 285             


Trp Thr Ala Gln Val Val Gly Asp Asp Ile Ala Trp Leu Lys Leu Arg 
    290                 295                 300                 


Glu Asp Gly Leu Tyr Ala Val Asn Pro Glu Asn Gly Phe Phe Gly Val 
305                 310                 315                 320 


Ala Pro Gly Thr Asn Tyr Ala Ser Asn Pro Ile Ala Met Lys Thr Met 
                325                 330                 335     


Glu Pro Gly Asn Thr Leu Phe Thr Asn Val Ala Leu Thr Asp Asp Gly 
            340                 345                 350         


Asp Ile Trp Trp Glu Gly Met Asp Gly Asp Ala Pro Ala His Leu Ile 
        355                 360                 365             


Asp Trp Met Gly Asn Asp Trp Thr Pro Glu Ser Asp Glu Asn Ala Ala 
    370                 375                 380                 


His Pro Asn Ser Arg Tyr Cys Val Ala Ile Asp Gln Ser Pro Ala Ala 
385                 390                 395                 400 


Ala Pro Glu Phe Asn Asp Trp Glu Gly Val Lys Ile Asp Ala Ile Leu 
                405                 410                 415     


Phe Gly Gly Arg Arg Ala Asp Thr Val Pro Leu Val Thr Gln Thr Tyr 
            420                 425                 430         


Asp Trp Glu His Gly Thr Met Val Gly Ala Leu Leu Ala Ser Gly Gln 
        435                 440                 445             


Thr Ala Ala Ser Ala Glu Ala Lys Val Gly Thr Leu Arg His Asp Pro 
    450                 455                 460                 


Met Ala Met Leu Pro Phe Ile Gly Tyr Asn Ala Gly Glu Tyr Leu Gln 
465                 470                 475                 480 


Asn Trp Ile Asp Met Gly Asn Lys Gly Gly Asp Lys Met Pro Ser Ile 
                485                 490                 495     


Phe Leu Val Asn Trp Phe Arg Arg Gly Glu Asp Gly Arg Phe Leu Trp 
            500                 505                 510         


Pro Gly Phe Gly Asp Asn Ser Arg Val Leu Lys Trp Val Ile Asp Arg 
        515                 520                 525             


Ile Glu Gly His Val Gly Ala Asp Glu Thr Val Val Gly His Thr Ala 
    530                 535                 540                 


Lys Ala Glu Asp Leu Asp Leu Asp Gly Leu Asp Thr Pro Ile Glu Asp 
545                 550                 555                 560 


Val Lys Glu Ala Leu Thr Ala Pro Ala Glu Gln Trp Ala Asn Asp Val 
                565                 570                 575     


Glu Asp Asn Ala Glu Tyr Leu Thr Phe Leu Gly Pro Arg Val Pro Ala 
            580                 585                 590         


Glu Val His Ser Gln Phe Asp Ala Leu Lys Ala Arg Ile Ser Ala Ala 
        595                 600                 605             


His Ala 
    610 


<210>  18
<211>  540
<212>  PRT
<213>  Escherichia coli

<400>  18

Met Arg Val Asn Asn Gly Leu Thr Pro Gln Glu Leu Glu Ala Tyr Gly 
1               5                   10                  15      


Ile Ser Asp Val His Asp Ile Val Tyr Asn Pro Ser Tyr Asp Leu Leu 
            20                  25                  30          


Tyr Gln Glu Glu Leu Asp Pro Ser Leu Thr Gly Tyr Glu Arg Gly Val 
        35                  40                  45              


Leu Thr Asn Leu Gly Ala Val Ala Val Asp Thr Gly Ile Phe Thr Gly 
    50                  55                  60                  


Arg Ser Pro Lys Asp Lys Tyr Ile Val Arg Asp Asp Thr Thr Arg Asp 
65                  70                  75                  80  


Thr Phe Trp Trp Ala Asp Lys Gly Lys Gly Lys Asn Asp Asn Lys Pro 
                85                  90                  95      


Leu Ser Pro Glu Thr Trp Gln His Leu Lys Gly Leu Val Thr Arg Gln 
            100                 105                 110         


Leu Ser Gly Lys Arg Leu Phe Val Val Asp Ala Phe Cys Gly Ala Asn 
        115                 120                 125             


Pro Asp Thr Arg Leu Ser Val Arg Phe Ile Thr Glu Val Ala Trp Gln 
    130                 135                 140                 


Ala His Phe Val Lys Asn Met Phe Ile Arg Pro Ser Asp Glu Glu Leu 
145                 150                 155                 160 


Ala Gly Phe Lys Pro Asp Phe Ile Val Met Asn Gly Ala Lys Cys Thr 
                165                 170                 175     


Asn Pro Gln Trp Lys Glu Gln Gly Leu Asn Ser Glu Asn Phe Val Ala 
            180                 185                 190         


Phe Asn Leu Thr Glu Arg Met Gln Leu Ile Gly Gly Thr Trp Tyr Gly 
        195                 200                 205             


Gly Glu Met Lys Lys Gly Met Phe Ser Met Met Asn Tyr Leu Leu Pro 
    210                 215                 220                 


Leu Lys Gly Ile Ala Ser Met His Cys Ser Ala Asn Val Gly Glu Lys 
225                 230                 235                 240 


Gly Asp Val Ala Val Phe Phe Gly Leu Ser Gly Thr Gly Lys Thr Thr 
                245                 250                 255     


Leu Ser Thr Asp Pro Lys Arg Arg Leu Ile Gly Asp Asp Glu His Gly 
            260                 265                 270         


Trp Asp Asp Asp Gly Val Phe Asn Phe Glu Gly Gly Cys Tyr Ala Lys 
        275                 280                 285             


Thr Ile Lys Leu Ser Lys Glu Ala Glu Pro Glu Ile Tyr Asn Ala Ile 
    290                 295                 300                 


Arg Arg Asp Ala Leu Leu Glu Asn Val Thr Val Arg Glu Asp Gly Thr 
305                 310                 315                 320 


Ile Asp Phe Asp Asp Gly Ser Lys Thr Glu Asn Thr Arg Val Ser Tyr 
                325                 330                 335     


Pro Ile Tyr His Ile Asp Asn Ile Val Lys Pro Val Ser Lys Ala Gly 
            340                 345                 350         


His Ala Thr Lys Val Ile Phe Leu Thr Ala Asp Ala Phe Gly Val Leu 
        355                 360                 365             


Pro Pro Val Ser Arg Leu Thr Ala Asp Gln Thr Gln Tyr His Phe Leu 
    370                 375                 380                 


Ser Gly Phe Thr Ala Lys Leu Ala Gly Thr Glu Arg Gly Ile Thr Glu 
385                 390                 395                 400 


Pro Thr Pro Thr Phe Ser Ala Cys Phe Gly Ala Ala Phe Leu Ser Leu 
                405                 410                 415     


His Pro Thr Gln Tyr Ala Glu Val Leu Val Lys Arg Met Gln Ala Ala 
            420                 425                 430         


Gly Ala Gln Ala Tyr Leu Val Asn Thr Gly Trp Asn Gly Thr Gly Lys 
        435                 440                 445             


Arg Ile Ser Ile Lys Asp Thr Arg Ala Ile Ile Asp Ala Ile Leu Asn 
    450                 455                 460                 


Gly Ser Leu Asp Asn Ala Glu Thr Phe Thr Leu Pro Met Phe Asn Leu 
465                 470                 475                 480 


Ala Ile Pro Thr Glu Leu Pro Gly Val Asp Thr Lys Ile Leu Asp Pro 
                485                 490                 495     


Arg Asn Thr Tyr Ala Ser Pro Glu Gln Trp Gln Glu Lys Ala Glu Thr 
            500                 505                 510         


Leu Ala Lys Leu Phe Ile Asp Asn Phe Asp Lys Tyr Thr Asp Thr Pro 
        515                 520                 525             


Ala Gly Ala Ala Leu Val Ala Ala Gly Pro Lys Leu 
    530                 535                 540 


<210>  19
<211>  266
<212>  PRT
<213>  Cupriavidus taiwanensis

<400>  19

Met Leu His Val Ser Met Val Gly Cys Gly Ala Ile Gly Arg Gly Val 
1               5                   10                  15      


Leu Glu Leu Leu Lys Ser Asp Pro Asp Val Val Phe Asp Val Val Ile 
            20                  25                  30          


Val Pro Glu His Thr Met Asp Glu Ala Arg Gly Ala Val Ser Ala Leu 
        35                  40                  45              


Ala Pro Arg Ala Arg Val Ala Thr His Leu Asp Asp Gln Arg Pro Asp 
    50                  55                  60                  


Leu Leu Val Glu Cys Ala Gly His His Ala Leu Glu Glu His Ile Val 
65                  70                  75                  80  


Pro Ala Leu Glu Arg Gly Ile Pro Cys Met Val Val Ser Val Gly Ala 
                85                  90                  95      


Leu Ser Glu Pro Gly Met Ala Glu Arg Leu Glu Ala Ala Ala Arg Arg 
            100                 105                 110         


Gly Gly Thr Gln Val Gln Leu Leu Ser Gly Ala Ile Gly Ala Ile Asp 
        115                 120                 125             


Ala Leu Ala Ala Ala Arg Val Gly Gly Leu Asp Glu Val Ile Tyr Thr 
    130                 135                 140                 


Gly Arg Lys Pro Ala Arg Ala Trp Thr Gly Thr Pro Ala Glu Gln Leu 
145                 150                 155                 160 


Phe Asp Leu Glu Ala Leu Thr Glu Ala Thr Val Ile Phe Glu Gly Thr 
                165                 170                 175     


Ala Arg Asp Ala Ala Arg Leu Tyr Pro Lys Asn Ala Asn Val Ala Ala 
            180                 185                 190         


Thr Val Ser Leu Ala Gly Leu Gly Leu Asp Arg Thr Ala Val Lys Leu 
        195                 200                 205             


Leu Ala Asp Pro His Ala Val Glu Asn Val His His Val Glu Ala Arg 
    210                 215                 220                 


Gly Ala Phe Gly Gly Phe Glu Leu Thr Met Arg Gly Lys Pro Leu Ala 
225                 230                 235                 240 


Ala Asn Pro Lys Thr Ser Ala Leu Thr Val Phe Ser Val Val Arg Ala 
                245                 250                 255     


Leu Gly Asn Arg Ala His Ala Val Ser Ile 
            260                 265     


<210>  20
<211>  267
<212>  PRT
<213>  Polaromonas sp.

<400>  20

Met Leu Lys Ile Ala Met Ile Gly Cys Gly Ala Ile Gly Ala Ser Val 
1               5                   10                  15      


Leu Glu Leu Leu His Gly Asp Ser Asp Val Val Val Asp Arg Val Ile 
            20                  25                  30          


Thr Val Pro Glu Ala Arg Asp Arg Thr Glu Ile Ala Val Ala Arg Trp 
        35                  40                  45              


Ala Pro Arg Ala Arg Val Leu Glu Val Leu Ala Ala Asp Asp Ala Pro 
    50                  55                  60                  


Asp Leu Val Val Glu Cys Ala Gly His Gly Ala Ile Ala Ala His Val 
65                  70                  75                  80  


Val Pro Ala Leu Glu Arg Gly Ile Pro Cys Val Val Thr Ser Val Gly 
                85                  90                  95      


Ala Leu Ser Ala Pro Gly Met Ala Gln Leu Leu Glu Gln Ala Ala Arg 
            100                 105                 110         


Arg Gly Lys Thr Gln Val Gln Leu Leu Ser Gly Ala Ile Gly Gly Ile 
        115                 120                 125             


Asp Ala Leu Ala Ala Ala Arg Val Gly Gly Leu Asp Ser Val Val Tyr 
    130                 135                 140                 


Thr Gly Arg Lys Pro Pro Met Ala Trp Lys Gly Thr Pro Ala Glu Ala 
145                 150                 155                 160 


Val Cys Asp Leu Asp Ser Leu Thr Val Ala His Cys Ile Phe Asp Gly 
                165                 170                 175     


Ser Ala Glu Gln Ala Ala Gln Leu Tyr Pro Lys Asn Ala Asn Val Ala 
            180                 185                 190         


Ala Thr Leu Ser Leu Ala Gly Leu Gly Leu Lys Arg Thr Gln Val Gln 
        195                 200                 205             


Leu Phe Ala Asp Pro Gly Val Ser Glu Asn Val His His Val Ala Ala 
    210                 215                 220                 


His Gly Ala Phe Gly Ser Phe Glu Leu Thr Met Arg Gly Arg Pro Leu 
225                 230                 235                 240 


Ala Ala Asn Pro Lys Thr Ser Ala Leu Thr Val Tyr Ser Val Val Arg 
                245                 250                 255     


Ala Leu Leu Asn Arg Gly Arg Ala Leu Val Ile 
            260                 265         


<210>  21
<211>  255
<212>  PRT
<213>  Klebsiella pneumoniae

<400>  21

Met Met Lys Lys Val Met Leu Ile Gly Tyr Gly Ala Met Ala Gln Ala 
1               5                   10                  15      


Val Ile Glu Arg Leu Pro Pro Gln Val Arg Val Glu Trp Ile Val Ala 
            20                  25                  30          


Arg Glu Ser His His Ala Ala Ile Cys Leu Gln Phe Gly Gln Ala Val 
        35                  40                  45              


Thr Pro Leu Thr Asp Pro Leu Gln Cys Gly Gly Thr Pro Asp Leu Val 
    50                  55                  60                  


Leu Glu Cys Ala Ser Gln Gln Ala Val Ala Gln Tyr Gly Glu Ala Val 
65                  70                  75                  80  


Leu Ala Arg Gly Trp His Leu Ala Val Ile Ser Thr Gly Ala Leu Ala 
                85                  90                  95      


Asp Ser Glu Leu Glu Gln Arg Leu Arg Gln Ala Gly Gly Lys Leu Thr 
            100                 105                 110         


Leu Leu Ala Gly Ala Val Ala Gly Ile Asp Gly Leu Ala Ala Ala Lys 
        115                 120                 125             


Glu Gly Gly Leu Glu Arg Val Thr Tyr Gln Ser Arg Lys Ser Pro Ala 
    130                 135                 140                 


Ser Trp Arg Gly Ser Tyr Ala Glu Gln Leu Ile Asp Leu Ser Ala Val 
145                 150                 155                 160 


Asn Glu Ala Gln Ile Phe Phe Glu Gly Ser Ala Arg Glu Ala Ala Arg 
                165                 170                 175     


Leu Phe Pro Ala Asn Ala Asn Val Ala Ala Thr Ile Ala Leu Gly Gly 
            180                 185                 190         


Ile Gly Leu Asp Ala Thr Arg Val Gln Leu Met Val Asp Pro Ala Thr 
        195                 200                 205             


Gln Arg Asn Thr His Thr Leu His Ala Glu Gly Leu Phe Gly Glu Phe 
    210                 215                 220                 


His Leu Glu Leu Ser Gly Leu Pro Leu Ala Ser Asn Pro Lys Thr Ser 
225                 230                 235                 240 


Thr Leu Ala Ala Leu Ser Ala Val Arg Ala Cys Arg Glu Leu Ala 
                245                 250                 255 


<210>  22
<211>  265
<212>  PRT
<213>  Delftia acidovarans

<400>  22

Met Asn Ile Ala Val Ile Gly Cys Gly Ala Ile Gly Ala Ser Val Leu 
1               5                   10                  15      


Glu Leu Leu Lys Gly His Ala Ala Val Gln Val Gly Trp Val Leu Val 
            20                  25                  30          


Pro Glu Val Thr Asp Ala Val Arg Ala Thr Leu Ala Leu His Ala Pro 
        35                  40                  45              


Lys Ala Arg Ala Val Pro Ala Leu Ala Ala Glu Asp Arg Pro Asp Leu 
    50                  55                  60                  


Ile Val Glu Cys Ala Gly His Ala Ala Ile Glu Glu His Val Leu Pro 
65                  70                  75                  80  


Ala Leu Arg Arg Gly Ile Pro Ala Val Val Ala Ser Ile Gly Ala Leu 
                85                  90                  95      


Ser Ala Pro Gly Met Ala Glu Ala Val Gln Ala Ala Ala Glu Ala Gly 
            100                 105                 110         


Gly Thr Gln Val Gln Leu Leu Ser Gly Ala Ile Gly Gly Val Asp Ala 
        115                 120                 125             


Leu Ala Ala Ala Arg Ile Gly Gly Leu Asp Glu Val Val Tyr Thr Gly 
    130                 135                 140                 


Arg Lys Pro Pro Met Ala Trp Thr Gly Thr Pro Ala Glu Gln Arg Cys 
145                 150                 155                 160 


Asp Leu Ala Ser Leu Lys Glu Ala Phe Cys Ile Phe Glu Gly Ser Ala 
                165                 170                 175     


Arg Glu Ala Ala Gln Leu Tyr Pro Lys Asn Ala Asn Val Ala Ala Thr 
            180                 185                 190         


Leu Ser Leu Ala Gly Met Gly Leu Asp Arg Thr Thr Val Arg Leu Tyr 
        195                 200                 205             


Ala Asp Pro Gly Val Asp Glu Asn Val His His Val Ala Ala Arg Gly 
    210                 215                 220                 


Ala Phe Gly Ser Met Glu Leu Thr Met Arg Gly Lys Pro Leu Ala Ala 
225                 230                 235                 240 


Asn Pro Lys Thr Ser Ala Leu Thr Val Tyr Ser Val Val Arg Ala Val 
                245                 250                 255     


Leu Asn Gln Ala Thr Ala Ile Ala Ile 
            260                 265 


<210>  23
<211>  267
<212>  PRT
<213>  Variovorax sp.

<400>  23

Met Thr Val Arg Ile Ala Leu Ile Gly Cys Gly Ala Ile Gly Thr Ala 
1               5                   10                  15      


Ala Leu Glu Leu Leu Arg Glu Asp Ala Gly Leu Ser Val Ala Ala Ile 
            20                  25                  30          


Val Val Pro Ala Glu Ala Phe Ala Ala Thr Lys Asp Val Ala Ala Arg 
        35                  40                  45              


Leu Ala Pro Gly Ala Gln Val Val Ser Ala Val Pro Ala Asp Gly Ile 
    50                  55                  60                  


Asp Leu Val Val Glu Ala Ala Gly His Ala Ala Ile Glu Ala His Val 
65                  70                  75                  80  


Leu Pro Ala Leu Gln Arg Gly Thr Pro Cys Val Val Ala Ser Val Gly 
                85                  90                  95      


Ala Leu Ser Ala Gln Gly Phe Ala Glu Lys Leu Glu Ala Ala Ala Val 
            100                 105                 110         


Ala Gly Lys Thr Gln Val Gln Leu Ile Ala Gly Ala Ile Gly Ala Ile 
        115                 120                 125             


Asp Ala Leu Ala Ala Ala Arg Ile Gly Gly Leu Asp Ser Val Arg Tyr 
    130                 135                 140                 


Thr Gly Arg Lys Pro Pro His Ala Trp Lys Gly Thr Pro Ala Glu Gln 
145                 150                 155                 160 


Gly Arg Asp Leu Gly Ala Leu Thr Gly Ala Thr Val Ile Phe Glu Gly 
                165                 170                 175     


Ser Ala Arg Glu Ala Ala Thr Leu Tyr Pro Lys Asn Ala Asn Val Ala 
            180                 185                 190         


Ala Thr Val Ser Leu Ala Gly Leu Gly Leu Asp Arg Thr Ser Val Arg 
        195                 200                 205             


Leu Ile Ala Asp Pro Thr Val Ala Glu Asn Val His Thr Val Glu Ala 
    210                 215                 220                 


Glu Gly Ala Phe Gly Asn Phe Glu Leu Thr Met Arg Asn Lys Pro Leu 
225                 230                 235                 240 


Ala Ala Asn Pro Lys Thr Ser Ala Leu Thr Val Tyr Ser Ala Val Arg 
                245                 250                 255     


Ala Leu Arg Asn Arg Val Ala Pro Leu Thr Ile 
            260                 265         


<210>  24
<211>  266
<212>  PRT
<213>  Comamonas testosteroni

<400>  24

Met Lys Asn Ile Ala Leu Ile Gly Cys Gly Ala Ile Gly Ser Ser Val 
1               5                   10                  15      


Leu Glu Leu Leu Ser Gly Asp Thr Gln Leu Gln Val Gly Trp Val Leu 
            20                  25                  30          


Val Pro Glu Ile Thr Pro Ala Val Arg Glu Thr Ala Ala Arg Leu Ala 
        35                  40                  45              


Pro Gln Ala Gln Leu Leu Gln Ala Leu Pro Gly Asp Ala Val Pro Asp 
    50                  55                  60                  


Leu Leu Val Glu Cys Ala Gly His Ala Ala Ile Glu Glu His Val Leu 
65                  70                  75                  80  


Pro Ala Leu Ala Arg Gly Ile Pro Ala Val Ile Ala Ser Ile Gly Ala 
                85                  90                  95      


Leu Ser Ala Pro Gly Met Ala Glu Arg Val Gln Ala Ala Ala Glu Thr 
            100                 105                 110         


Gly Lys Thr Gln Ala Gln Leu Leu Ser Gly Ala Ile Gly Gly Ile Asp 
        115                 120                 125             


Ala Leu Ala Ala Ala Arg Val Gly Gly Leu Glu Thr Val Leu Tyr Thr 
    130                 135                 140                 


Gly Arg Lys Pro Pro Lys Ala Trp Ser Gly Thr Pro Ala Glu Gln Val 
145                 150                 155                 160 


Cys Asp Leu Asp Gly Leu Thr Glu Ala Phe Cys Ile Phe Glu Gly Ser 
                165                 170                 175     


Ala Arg Glu Ala Ala Gln Leu Tyr Pro Lys Asn Ala Asn Val Ala Ala 
            180                 185                 190         


Thr Leu Ser Leu Ala Gly Leu Gly Leu Asp Lys Thr Met Val Arg Leu 
        195                 200                 205             


Phe Ala Asp Pro Gly Val Gln Glu Asn Val His Gln Val Glu Ala Arg 
    210                 215                 220                 


Gly Ala Phe Gly Ala Met Glu Leu Thr Met Arg Gly Lys Pro Leu Ala 
225                 230                 235                 240 


Ala Asn Pro Lys Thr Ser Ala Leu Thr Val Tyr Ser Val Val Arg Ala 
                245                 250                 255     


Val Leu Asn Asn Val Ala Pro Leu Ala Ile 
            260                 265     


<210>  25
<211>  266
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  25

Met Lys Asn Ile Ala Leu Ile Gly Cys Gly Ala Ile Gly Ser Ser Val 
1               5                   10                  15      


Leu Glu Leu Leu Ser Gly Asp Thr Gln Leu Gln Val Gly Trp Val Leu 
            20                  25                  30          


Val Pro Glu Ile Thr Pro Ala Val Arg Glu Thr Ala Ala Arg Leu Ala 
        35                  40                  45              


Pro Gln Ala Gln Leu Leu Gln Ala Leu Pro Gly Asp Ala Val Pro Asp 
    50                  55                  60                  


Leu Leu Val Glu Cys Ala Gly His Ala Ala Ile Glu Glu His Val Leu 
65                  70                  75                  80  


Pro Ala Leu Ala Arg Gly Ile Pro Ala Val Ile Ala Ser Ile Gly Ala 
                85                  90                  95      


Leu Ser Ala Pro Gly Met Ala Glu Arg Val Gln Ala Ala Ala Glu Thr 
            100                 105                 110         


Gly Lys Thr Gln Ala Gln Leu Leu Ser Gly Ala Ile Gly Gly Ile Asp 
        115                 120                 125             


Ala Leu Ala Ala Ala Arg Val Gly Gly Leu Glu Thr Val Leu Tyr Thr 
    130                 135                 140                 


Gly Arg Lys Pro Pro Lys Ala Trp Ser Gly Thr Pro Ala Glu Gln Val 
145                 150                 155                 160 


Cys Asp Leu Asp Gly Leu Thr Glu Ala Phe Cys Ile Phe Glu Gly Ser 
                165                 170                 175     


Ala Arg Glu Ala Ala Gln Leu Tyr Pro Lys Asn Ala Asn Val Ala Ala 
            180                 185                 190         


Thr Leu Ser Leu Ala Gly Leu Gly Leu Asp Lys Thr Met Val Arg Leu 
        195                 200                 205             


Phe Ala Asp Pro Gly Val Gln Glu Asn Val His Gln Val Glu Ala Arg 
    210                 215                 220                 


Gly Ala Phe Gly Ala Met Glu Leu Thr Met Arg Gly Lys Pro Leu Ala 
225                 230                 235                 240 


Ala Asn Pro Lys Thr Ser Ala Leu Thr Val Tyr Ser Val Val Arg Ala 
                245                 250                 255     


Val Leu Asn Asn Val Ala Pro Leu Ala Ile 
            260                 265     


<210>  26
<211>  419
<212>  PRT
<213>  Corynebacterium diphtheriae

<400>  26

Met Ser Leu Lys Asp Tyr Asp Ala Ala Arg Leu Ala Gln Val Arg Glu 
1               5                   10                  15      


Glu Val Thr Ala Lys Tyr Ala Glu Leu Lys Ala Lys Asn Leu Ser Leu 
            20                  25                  30          


Asp Leu Thr Arg Gly Lys Pro Ser Ala Glu Gln Leu Asp Leu Ser Asn 
        35                  40                  45              


Asp Leu Leu Ser Leu Pro Gly Gly Asp Phe Arg Thr Lys Asp Gly Val 
    50                  55                  60                  


Asp Cys Arg Asn Tyr Gly Gly Leu Leu Gly Ile Ala Asp Ile Arg Glu 
65                  70                  75                  80  


Leu Trp Ala Glu Ala Leu Gly Leu Pro Ala Asp Leu Val Val Ala Gln 
                85                  90                  95      


Asp Gly Ser Ser Leu Asn Ile Met Phe Asp Leu Ile Ser Trp Ser Tyr 
            100                 105                 110         


Thr Trp Gly Asn Asn Asp Ser Ser Arg Pro Trp Ser Ala Glu Glu Lys 
        115                 120                 125             


Val Lys Trp Leu Cys Pro Val Pro Gly Tyr Asp Arg His Phe Thr Ile 
    130                 135                 140                 


Thr Glu His Phe Gly Phe Glu Met Ile Asn Val Pro Met Thr Asp Glu 
145                 150                 155                 160 


Gly Pro Asp Met Gly Val Val Arg Glu Leu Val Lys Asp Pro Gln Val 
                165                 170                 175     


Lys Gly Met Trp Thr Val Pro Val Phe Gly Asn Pro Thr Gly Val Thr 
            180                 185                 190         


Phe Ser Glu Gln Thr Cys Arg Glu Leu Ala Glu Met Ser Thr Ala Ala 
        195                 200                 205             


Pro Asp Phe Arg Ile Val Trp Asp Asn Ala Tyr Ala Leu His Thr Leu 
    210                 215                 220                 


Ser Asp Glu Phe Pro Ile Val His Asn Val Ile Glu Phe Ala Gln Ala 
225                 230                 235                 240 


Ala Gly Asn Pro Asn Arg Phe Trp Phe Met Ser Ser Thr Ser Lys Ile 
                245                 250                 255     


Thr His Ala Gly Ser Gly Val Ser Phe Phe Ala Ser Ser Lys Glu Asn 
            260                 265                 270         


Ile Glu Trp Tyr Ala Ser His Ala Asn Val Arg Gly Ile Gly Pro Asn 
        275                 280                 285             


Lys Leu Asn Gln Leu Ala His Ala Gln Phe Phe Gly Asp Val Ala Gly 
    290                 295                 300                 


Leu Lys Ala His Met Leu Lys His Ala Ala Ser Leu Ala Pro Lys Phe 
305                 310                 315                 320 


Glu Arg Val Leu Glu Ile Leu Asp Ser Arg Leu Ser Glu Tyr Gly Val 
                325                 330                 335     


Ala Lys Trp Thr Ser Pro Thr Gly Gly Tyr Phe Ile Ser Val Asp Val 
            340                 345                 350         


Val Pro Gly Thr Ala Ser Arg Val Val Glu Leu Ala Lys Glu Ala Gly 
        355                 360                 365             


Ile Ala Leu Thr Gly Ala Gly Ser Ser Phe Pro Leu His Asn Asp Pro 
    370                 375                 380                 


Asn Asn Glu Asn Ile Arg Leu Ala Pro Ser Leu Pro Pro Val Ala Glu 
385                 390                 395                 400 


Leu Glu Val Ala Met Asp Gly Phe Ala Thr Cys Val Leu Met Ala Ala 
                405                 410                 415     


Leu Glu Val 
            


<210>  27
<211>  422
<212>  PRT
<213>  Deinococcus geothermalis

<400>  27

Met Thr Lys Glu Ala Ser Arg Pro Ala Leu Asp Leu Ala Arg Gln Ala 
1               5                   10                  15      


Tyr Glu Ala Phe Lys Ala Arg Gly Leu Asn Leu Asn Met Gln Arg Gly 
            20                  25                  30          


Gln Pro Ala Asp Ala Asp Phe Asp Leu Ser Asn Gly Leu Leu Thr Val 
        35                  40                  45              


Leu Gly Ala Glu Asp Val Arg Met Asp Gly Leu Asp Leu Arg Asn Tyr 
    50                  55                  60                  


Pro Gly Gly Val Ala Gly Leu Pro Ser Ala Arg Ala Leu Phe Ala Gly 
65                  70                  75                  80  


Tyr Leu Asp Val Lys Ala Glu Asn Val Leu Val Trp Asn Asn Ser Ser 
                85                  90                  95      


Leu Glu Leu Gln Gly Leu Val Leu Thr Phe Ala Leu Leu His Gly Val 
            100                 105                 110         


Arg Gly Ser Thr Gly Pro Trp Leu Ser Gln Thr Pro Lys Met Ile Val 
        115                 120                 125             


Thr Val Pro Gly Tyr Asp Arg His Phe Leu Leu Leu Gln Thr Leu Gly 
    130                 135                 140                 


Phe Glu Leu Leu Thr Val Asp Met Gln Ser Asp Gly Pro Asp Val Asp 
145                 150                 155                 160 


Ala Val Glu Arg Leu Ala Gly Thr Asp Pro Ser Val Lys Gly Ile Leu 
                165                 170                 175     


Phe Val Pro Thr Tyr Ser Asn Pro Gly Gly Glu Thr Ile Ser Leu Glu 
            180                 185                 190         


Lys Ala Arg Arg Leu Ala Gly Leu Gln Ala Ala Ala Pro Asp Phe Thr 
        195                 200                 205             


Ile Phe Ala Asp Asp Ala Tyr Arg Val His His Leu Val Glu Glu Asp 
    210                 215                 220                 


Arg Ala Glu Pro Val Asn Phe Val Val Leu Ala Arg Asp Ala Gly Tyr 
225                 230                 235                 240 


Pro Asp Arg Ala Phe Val Phe Ala Ser Thr Ser Lys Ile Thr Phe Ala 
                245                 250                 255     


Gly Ala Gly Leu Gly Phe Val Ala Ser Ser Glu Asp Asn Ile Arg Trp 
            260                 265                 270         


Leu Ser Lys Tyr Leu Gly Ala Gln Ser Ile Gly Pro Asn Lys Val Glu 
        275                 280                 285             


Gln Ala Arg His Val Lys Phe Leu Thr Glu Tyr Pro Gly Gly Leu Glu 
    290                 295                 300                 


Gly Leu Met Arg Asp His Ala Ala Ile Ile Ala Pro Lys Phe Arg Ala 
305                 310                 315                 320 


Val Asp Glu Val Leu Arg Ala Glu Leu Gly Glu Gly Gly Glu Tyr Ala 
                325                 330                 335     


Thr Trp Thr Leu Pro Lys Gly Gly Tyr Phe Ile Ser Leu Asp Thr Ala 
            340                 345                 350         


Glu Pro Val Ala Asp Arg Val Val Lys Leu Ala Glu Ala Ala Gly Val 
        355                 360                 365             


Ser Leu Thr Pro Ala Gly Ala Thr Tyr Pro Ala Gly Gln Asp Pro His 
    370                 375                 380                 


Asn Arg Asn Leu Arg Leu Ala Pro Thr Arg Pro Pro Val Glu Glu Val 
385                 390                 395                 400 


Arg Thr Ala Met Gln Val Val Ala Ala Cys Ile Arg Leu Ala Thr Glu 
                405                 410                 415     


Glu Tyr Arg Ala Gly His 
            420         


<210>  28
<211>  435
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  28

Met Ser Phe Asp Ser Leu Ser Pro Gln Glu Leu Ala Ala Leu His Ala 
1               5                   10                  15      


Arg His Gln Gln Asp Tyr Ala Ala Leu Gln Gly Met Lys Leu Ala Leu 
            20                  25                  30          


Asp Leu Thr Arg Gly Lys Pro Ser Ala Glu Gln Leu Asp Leu Ser Asn 
        35                  40                  45              


Gln Leu Leu Ser Leu Pro Gly Asp Asp Tyr Arg Asp Pro Glu Gly Thr 
    50                  55                  60                  


Asp Thr Arg Asn Tyr Gly Gly Gln His Gly Leu Pro Gly Leu Arg Ala 
65                  70                  75                  80  


Ile Phe Ala Glu Leu Leu Gly Ile Ala Val Pro Asn Leu Ile Ala Gly 
                85                  90                  95      


Asn Asn Ser Ser Leu Glu Leu Met His Asp Ile Val Ala Phe Ser Met 
            100                 105                 110         


Leu Tyr Gly Gly Val Asp Ser Pro Arg Pro Trp Ile Gln Glu Gln Asp 
        115                 120                 125             


Gly Ile Lys Phe Leu Cys Pro Val Pro Gly Tyr Asp Arg His Phe Ala 
    130                 135                 140                 


Ile Thr Glu Thr Met Gly Ile Glu Met Ile Pro Ile Pro Met Leu Gln 
145                 150                 155                 160 


Asp Gly Pro Asp Val Asp Leu Ile Glu Glu Leu Val Ala Val Asp Pro 
                165                 170                 175     


Ala Ile Lys Gly Met Trp Thr Val Pro Val Phe Gly Asn Pro Ser Gly 
            180                 185                 190         


Val Thr Tyr Ser Trp Glu Thr Val Arg Arg Leu Val Gln Met Arg Thr 
        195                 200                 205             


Ala Ala Pro Asp Phe Arg Leu Phe Trp Asp Asn Ala Tyr Ala Val His 
    210                 215                 220                 


Thr Leu Thr Leu Asp Phe Pro Arg Gln Val Asp Val Leu Gly Leu Ala 
225                 230                 235                 240 


Ala Lys Ala Gly Asn Pro Asn Arg Pro Tyr Val Phe Ala Ser Thr Ser 
                245                 250                 255     


Lys Ile Thr Phe Ala Gly Gly Gly Val Ser Phe Phe Gly Gly Ser Leu 
            260                 265                 270         


Gly Asn Ile Ala Trp Tyr Leu Gln Tyr Ala Gly Lys Lys Ser Ile Gly 
        275                 280                 285             


Pro Asp Lys Val Asn Gln Leu Arg His Leu Arg Phe Phe Gly Asp Ala 
    290                 295                 300                 


Asp Gly Val Arg Leu His Met Leu Arg His Gln Gln Ile Leu Ala Pro 
305                 310                 315                 320 


Lys Phe Ala Leu Val Ala Glu Val Leu Asp Gln Arg Leu Ser Glu Ser 
                325                 330                 335     


Lys Ile Ala Ser Trp Thr Glu Pro Lys Gly Gly Tyr Phe Ile Ser Leu 
            340                 345                 350         


Asp Val Leu Pro Gly Thr Ala Arg Arg Thr Val Ala Leu Ala Lys Asp 
        355                 360                 365             


Val Gly Ile Ala Val Thr Glu Ala Gly Ala Ser Phe Pro Tyr Arg Lys 
    370                 375                 380                 


Asp Pro Asp Asp Lys Asn Ile Arg Ile Ala Pro Ser Phe Pro Ser Val 
385                 390                 395                 400 


Pro Asp Leu Arg Asn Ala Val Asp Gly Leu Ala Thr Cys Ala Leu Leu 
                405                 410                 415     


Ala Ala Thr Glu Thr Leu Leu Asn Gln Gly Leu Ala Ser Ser Ala Pro 
            420                 425                 430         


Asn Val Arg 
        435 


<210>  29
<211>  136
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  29

Met Leu Arg Thr Ile Leu Gly Ser Lys Ile His Arg Ala Thr Val Thr 
1               5                   10                  15      


Gln Ala Asp Leu Asp Tyr Val Gly Ser Val Thr Ile Asp Ala Asp Leu 
            20                  25                  30          


Val His Ala Ala Gly Leu Ile Glu Gly Glu Lys Val Ala Ile Val Asp 
        35                  40                  45              


Ile Thr Asn Gly Ala Arg Leu Glu Thr Tyr Val Ile Val Gly Asp Ala 
    50                  55                  60                  


Gly Thr Gly Asn Ile Cys Ile Asn Gly Ala Ala Ala His Leu Ile Asn 
65                  70                  75                  80  


Pro Gly Asp Leu Val Ile Ile Met Ser Tyr Leu Gln Ala Thr Asp Ala 
                85                  90                  95      


Glu Ala Lys Ala Tyr Glu Pro Lys Ile Val His Val Asp Ala Asp Asn 
            100                 105                 110         


Arg Ile Val Ala Leu Gly Asn Asp Leu Ala Glu Ala Leu Pro Gly Ser 
        115                 120                 125             


Gly Leu Leu Thr Ser Arg Ser Ile 
    130                 135     


<210>  30
<211>  1511
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  30

Met Ser Ser Thr Asp Glu His Ile Glu Lys Asp Ile Ser Ser Arg Ser 
1               5                   10                  15      


Asn His Asp Asp Asp Tyr Ala Asn Ser Val Gln Ser Tyr Ala Ala Ser 
            20                  25                  30          


Glu Gly Gln Val Asp Asn Glu Asp Leu Ala Ala Thr Ser Gln Leu Ser 
        35                  40                  45              


Arg His Leu Ser Asn Ile Leu Ser Asn Glu Glu Gly Ile Glu Arg Leu 
    50                  55                  60                  


Glu Ser Met Ala Arg Val Ile Ser His Lys Thr Lys Lys Glu Met Asp 
65                  70                  75                  80  


Ser Phe Glu Ile Asn Asp Leu Asp Phe Asp Leu Arg Ser Leu Leu His 
                85                  90                  95      


Tyr Leu Arg Ser Arg Gln Leu Glu Gln Gly Ile Glu Pro Gly Asp Ser 
            100                 105                 110         


Gly Ile Ala Phe Lys Asn Leu Thr Ala Val Gly Val Asp Ala Ser Ala 
        115                 120                 125             


Ala Tyr Gly Pro Ser Val Glu Glu Met Phe Arg Asn Ile Ala Ser Ile 
    130                 135                 140                 


Pro Ala His Leu Ile Ser Lys Phe Thr Lys Lys Ser Asp Val Pro Leu 
145                 150                 155                 160 


Arg Asn Ile Ile Gln Asn Cys Thr Gly Val Val Glu Ser Gly Glu Met 
                165                 170                 175     


Leu Phe Val Val Gly Arg Pro Gly Ala Gly Cys Ser Thr Phe Leu Lys 
            180                 185                 190         


Cys Leu Ser Gly Glu Thr Ser Glu Leu Val Asp Val Gln Gly Glu Phe 
        195                 200                 205             


Ser Tyr Asp Gly Leu Asp Gln Ser Glu Met Met Ser Lys Tyr Lys Gly 
    210                 215                 220                 


Tyr Val Ile Tyr Cys Pro Glu Leu Asp Phe His Phe Pro Lys Ile Thr 
225                 230                 235                 240 


Val Lys Glu Thr Ile Asp Phe Ala Leu Lys Cys Lys Thr Pro Arg Val 
                245                 250                 255     


Arg Ile Asp Lys Met Thr Arg Lys Gln Tyr Val Asp Asn Ile Arg Asp 
            260                 265                 270         


Met Trp Cys Thr Val Phe Gly Leu Arg His Thr Tyr Ala Thr Lys Val 
        275                 280                 285             


Gly Asn Asp Phe Val Arg Gly Val Ser Gly Gly Glu Arg Lys Arg Val 
    290                 295                 300                 


Ser Leu Val Glu Ala Gln Ala Met Asn Ala Ser Ile Tyr Ser Trp Asp 
305                 310                 315                 320 


Asn Ala Thr Arg Gly Leu Asp Ala Ser Thr Ala Leu Glu Phe Ala Gln 
                325                 330                 335     


Ala Ile Arg Thr Ala Thr Asn Met Val Asn Asn Ser Ala Ile Val Ala 
            340                 345                 350         


Ile Tyr Gln Ala Gly Glu Asn Ile Tyr Glu Leu Phe Asp Lys Thr Thr 
        355                 360                 365             


Val Leu Tyr Asn Gly Arg Gln Ile Tyr Phe Gly Pro Ala Asp Lys Ala 
    370                 375                 380                 


Val Gly Tyr Phe Gln Arg Met Gly Trp Val Lys Pro Asn Arg Met Thr 
385                 390                 395                 400 


Ser Ala Glu Phe Leu Thr Ser Val Thr Val Asp Phe Glu Asn Arg Thr 
                405                 410                 415     


Leu Asp Ile Lys Pro Gly Tyr Glu Asp Lys Val Pro Lys Ser Ser Ser 
            420                 425                 430         


Glu Phe Glu Glu Tyr Trp Leu Asn Ser Glu Asp Tyr Gln Glu Leu Leu 
        435                 440                 445             


Arg Thr Tyr Asp Asp Tyr Gln Ser Arg His Pro Val Asn Glu Thr Arg 
    450                 455                 460                 


Asp Arg Leu Asp Val Ala Lys Lys Gln Arg Leu Gln Gln Gly Gln Arg 
465                 470                 475                 480 


Glu Asn Ser Gln Tyr Val Val Asn Tyr Trp Thr Gln Val Tyr Tyr Cys 
                485                 490                 495     


Met Ile Arg Gly Phe Gln Arg Val Lys Gly Asp Ser Thr Tyr Thr Lys 
            500                 505                 510         


Val Tyr Leu Ser Ser Phe Leu Ile Lys Ala Leu Ile Ile Gly Ser Met 
        515                 520                 525             


Phe His Lys Ile Asp Asp Lys Ser Gln Ser Thr Thr Ala Gly Ala Tyr 
    530                 535                 540                 


Ser Arg Gly Gly Met Leu Phe Tyr Val Leu Leu Phe Ala Ser Val Thr 
545                 550                 555                 560 


Ser Leu Ala Glu Ile Gly Asn Ser Phe Ser Ser Arg Pro Val Ile Val 
                565                 570                 575     


Lys His Lys Ser Tyr Ser Met Tyr His Leu Ser Ala Glu Ser Leu Gln 
            580                 585                 590         


Glu Ile Ile Thr Glu Phe Pro Thr Lys Phe Val Ala Ile Val Ile Leu 
        595                 600                 605             


Cys Leu Ile Thr Tyr Trp Ile Pro Phe Met Lys Tyr Glu Ala Gly Ala 
    610                 615                 620                 


Phe Phe Gln Tyr Ile Leu Tyr Leu Leu Thr Val Gln Gln Cys Thr Ser 
625                 630                 635                 640 


Phe Ile Phe Lys Phe Val Ala Thr Met Ser Lys Ser Gly Val Asp Ala 
                645                 650                 655     


His Ala Val Gly Gly Leu Trp Val Leu Met Leu Cys Val Tyr Ala Gly 
            660                 665                 670         


Phe Val Leu Pro Ile Gly Glu Met His His Trp Ile Arg Trp Leu His 
        675                 680                 685             


Phe Ile Asn Pro Leu Thr Tyr Ala Phe Glu Ser Leu Val Ser Thr Glu 
    690                 695                 700                 


Phe His His Arg Glu Met Leu Cys Ser Ala Leu Val Pro Ser Gly Pro 
705                 710                 715                 720 


Gly Tyr Glu Gly Ile Ser Ile Ala Asn Gln Val Cys Asp Ala Ala Gly 
                725                 730                 735     


Ala Val Lys Gly Asn Leu Tyr Val Ser Gly Asp Ser Tyr Ile Leu His 
            740                 745                 750         


Gln Tyr His Phe Ala Tyr Lys His Ala Trp Arg Asn Trp Gly Val Asn 
        755                 760                 765             


Ile Val Trp Thr Phe Gly Tyr Ile Val Phe Asn Val Ile Leu Ser Glu 
    770                 775                 780                 


Tyr Leu Lys Pro Val Glu Gly Gly Gly Asp Leu Leu Leu Tyr Lys Arg 
785                 790                 795                 800 


Gly His Met Pro Glu Leu Gly Thr Glu Asn Ala Asp Ala Arg Thr Ala 
                805                 810                 815     


Ser Arg Glu Glu Met Met Glu Ala Leu Asn Gly Pro Asn Val Asp Leu 
            820                 825                 830         


Glu Lys Val Ile Ala Glu Lys Asp Val Phe Thr Trp Asn His Leu Asp 
        835                 840                 845             


Tyr Thr Ile Pro Tyr Asp Gly Ala Thr Arg Lys Leu Leu Ser Asp Val 
    850                 855                 860                 


Phe Gly Tyr Val Lys Pro Gly Lys Met Thr Ala Leu Met Gly Glu Ser 
865                 870                 875                 880 


Gly Ala Gly Lys Thr Thr Leu Leu Asn Val Leu Ala Gln Arg Ile Asn 
                885                 890                 895     


Met Gly Val Ile Thr Gly Asp Met Leu Val Asn Ala Lys Pro Leu Pro 
            900                 905                 910         


Ala Ser Phe Asn Arg Ser Cys Gly Tyr Val Ala Gln Ala Asp Asn His 
        915                 920                 925             


Met Ala Glu Leu Ser Val Arg Glu Ser Leu Arg Phe Ala Ala Glu Leu 
    930                 935                 940                 


Arg Gln Gln Ser Ser Val Pro Leu Glu Glu Lys Tyr Glu Tyr Val Glu 
945                 950                 955                 960 


Lys Ile Ile Thr Leu Leu Gly Met Gln Asn Tyr Ala Glu Ala Leu Val 
                965                 970                 975     


Gly Lys Thr Gly Arg Gly Leu Asn Val Glu Gln Arg Lys Lys Leu Ser 
            980                 985                 990         


Ile Gly Val Glu Leu Val Ala Lys  Pro Ser Leu Leu Leu  Phe Leu Asp 
        995                 1000                 1005             


Glu Pro  Thr Ser Gly Leu Asp  Ser Gln Ser Ala Trp  Ser Ile Val 
    1010                 1015                 1020             


Gln Phe  Met Arg Ala Leu Ala  Asp Ser Gly Gln Ser  Ile Leu Cys 
    1025                 1030                 1035             


Thr Ile  His Gln Pro Ser Ala  Thr Leu Phe Glu Gln  Phe Asp Arg 
    1040                 1045                 1050             


Leu Leu  Leu Leu Lys Lys Gly  Gly Lys Met Val Tyr  Phe Gly Asp 
    1055                 1060                 1065             


Ile Gly  Pro Asn Ser Glu Thr  Leu Leu Lys Tyr Phe  Glu Arg Gln 
    1070                 1075                 1080             


Ser Gly  Met Lys Cys Gly Val  Ser Glu Asn Pro Ala  Glu Tyr Ile 
    1085                 1090                 1095             


Leu Asn  Cys Ile Gly Ala Gly  Ala Thr Ala Ser Val  Asn Ser Asp 
    1100                 1105                 1110             


Trp His  Asp Leu Trp Leu Ala  Ser Pro Glu Cys Ala  Ala Ala Arg 
    1115                 1120                 1125             


Ala Glu  Val Glu Glu Leu His  Arg Thr Leu Pro Gly  Arg Ala Val 
    1130                 1135                 1140             


Asn Asp  Asp Pro Glu Leu Ala  Thr Arg Phe Ala Ala  Ser Tyr Met 
    1145                 1150                 1155             


Thr Gln  Ile Lys Cys Val Leu  Arg Arg Thr Ala Leu  Gln Phe Trp 
    1160                 1165                 1170             


Arg Ser  Pro Val Tyr Ile Arg  Ala Lys Phe Phe Glu  Cys Val Ala 
    1175                 1180                 1185             


Cys Ala  Leu Phe Val Gly Leu  Ser Tyr Val Gly Val  Asn His Ser 
    1190                 1195                 1200             


Val Gly  Gly Ala Ile Glu Ala  Phe Ser Ser Ile Phe  Met Leu Leu 
    1205                 1210                 1215             


Leu Ile  Ala Leu Ala Met Ile  Asn Gln Leu His Val  Phe Ala Tyr 
    1220                 1225                 1230             


Asp Ser  Arg Glu Leu Tyr Glu  Val Arg Glu Ala Ala  Ser Asn Thr 
    1235                 1240                 1245             


Phe His  Trp Ser Val Leu Leu  Leu Cys His Ala Ala  Val Glu Asn 
    1250                 1255                 1260             


Phe Trp  Ser Thr Leu Cys Gln  Phe Met Cys Phe Ile  Cys Tyr Tyr 
    1265                 1270                 1275             


Trp Pro  Ala Gln Phe Ser Gly  Arg Ala Ser His Ala  Gly Phe Phe 
    1280                 1285                 1290             


Phe Phe  Phe Tyr Val Leu Ile  Phe Pro Leu Tyr Phe  Val Thr Tyr 
    1295                 1300                 1305             


Gly Leu  Trp Ile Leu Tyr Met  Ser Pro Asp Val Pro  Ser Ala Ser 
    1310                 1315                 1320             


Met Ile  Asn Ser Asn Leu Phe  Ala Ala Met Leu Leu  Phe Cys Gly 
    1325                 1330                 1335             


Ile Leu  Gln Pro Arg Glu Lys  Met Pro Ala Phe Trp  Arg Arg Leu 
    1340                 1345                 1350             


Met Tyr  Asn Val Ser Pro Phe  Thr Tyr Val Val Gln  Ala Leu Val 
    1355                 1360                 1365             


Thr Pro  Leu Val His Asn Lys  Lys Val Val Cys Asn  Pro His Glu 
    1370                 1375                 1380             


Tyr Asn  Ile Met Asp Pro Pro  Ser Gly Lys Thr Cys  Gly Glu Phe 
    1385                 1390                 1395             


Leu Ser  Thr Tyr Met Asp Asn  Asn Thr Gly Tyr Leu  Val Asn Pro 
    1400                 1405                 1410             


Thr Ala  Thr Glu Asn Cys Gln  Tyr Cys Pro Tyr Thr  Val Gln Asp 
    1415                 1420                 1425             


Gln Val  Val Ala Lys Tyr Asn  Val Lys Trp Asp His  Arg Trp Arg 
    1430                 1435                 1440             


Asn Phe  Gly Phe Met Trp Ala  Tyr Ile Cys Phe Asn  Ile Ala Ala 
    1445                 1450                 1455             


Met Leu  Ile Cys Tyr Tyr Val  Val Arg Val Lys Val  Trp Ser Leu 
    1460                 1465                 1470             


Lys Ser  Val Leu Asn Phe Lys  Lys Trp Phe Asn Gly  Pro Arg Lys 
    1475                 1480                 1485             


Glu Arg  His Glu Lys Asp Thr  Asn Ile Phe Gln Thr  Val Pro Gly 
    1490                 1495                 1500             


Asp Glu  Asn Lys Ile Thr Lys  Lys 
    1505                 1510     


<210>  31
<211>  944
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  31

Met Asp Thr Gln Ile Ala Ile Thr Gly Val Ala Val Gly Lys Glu Ile 
1               5                   10                  15      


Asn Asn Asp Asn Ser Lys Thr Asp Gln Lys Val Ser Leu Pro Lys Ala 
            20                  25                  30          


Asp Val Pro Cys Ile Asp Lys Ala Thr Gln Thr Ile Ile Glu Gly Cys 
        35                  40                  45              


Ser Lys Asp Asp Pro Arg Leu Ser Tyr Pro Thr Lys Leu Glu Thr Thr 
    50                  55                  60                  


Glu Lys Gly Lys Thr Lys Arg Asn Ser Phe Ala Cys Val Cys Cys His 
65                  70                  75                  80  


Ser Leu Lys Gln Lys Cys Glu Pro Ser Asp Val Asn Asp Ile Tyr Arg 
                85                  90                  95      


Lys Pro Cys Arg Arg Cys Leu Lys His Lys Lys Leu Cys Lys Phe Asp 
            100                 105                 110         


Leu Ser Lys Arg Thr Arg Lys Arg Lys Pro Arg Ser Arg Ser Pro Thr 
        115                 120                 125             


Pro Phe Glu Ser Pro Met Val Asn Val Ser Thr Lys Ser Lys Gly Pro 
    130                 135                 140                 


Thr Asp Ser Glu Glu Ser Ser Leu Lys Asp Gly Thr Ser Tyr Leu Ala 
145                 150                 155                 160 


Ser Phe Pro Ser Asp Pro Asn Ala Lys Gln Phe Pro Asn Ser Arg Thr 
                165                 170                 175     


Val Leu Pro Gly Leu Gln Gln Ser Leu Ser Asp Leu Trp Ser Thr Leu 
            180                 185                 190         


Ser Gln Pro Pro Ser Tyr Gly Ala Arg Glu Ala Glu Thr Thr Ser Thr 
        195                 200                 205             


Gly Glu Ile Thr Thr Asn Asn His Thr Lys Ser Asn Gly Ser Val Pro 
    210                 215                 220                 


Thr Asn Pro Ala Val Leu Ala Ser Asn Asp Glu His Thr Asn Ile Ser 
225                 230                 235                 240 


Asp Ala Pro Val Ile Tyr Ser Thr Tyr Asn Ser Pro Val Pro Ile Ser 
                245                 250                 255     


Ser Ala Pro Thr Ser Ile Asn Ser Glu Ala Leu Phe Lys His Arg Pro 
            260                 265                 270         


Lys Ile Val Gly Asp Glu Glu Thr Gln Asn Val Lys Val Lys Arg Gln 
        275                 280                 285             


Lys Lys Ser Tyr Ser Arg His Met Thr Arg Ser Phe Arg Lys Gln Leu 
    290                 295                 300                 


Gln Ser Leu Ile Ile Ser Gln Lys Gly Lys Ile Arg Asp Ile Ser Met 
305                 310                 315                 320 


Lys Leu Asp Thr Trp Ser Lys Gln Trp Asn Asp Leu Val Glu Lys Ser 
                325                 330                 335     


Met Phe Leu Pro Thr Ile Ala Asp Pro Val Ser Val Gly Ile Ile Ser 
            340                 345                 350         


His Glu Glu Ala Thr Leu Arg Leu His Leu Tyr Lys Thr Glu Ile Ser 
        355                 360                 365             


Tyr Leu Ser Lys Leu Pro Phe Ile Lys Val Glu Glu Asn Val Ser Val 
    370                 375                 380                 


Asp Glu Leu Arg Lys Lys Lys Pro Ile Leu Phe Ser Val Ile Met Ser 
385                 390                 395                 400 


Cys Val Ser Ile Val Leu Thr Pro Lys Gln Thr Thr Arg Gly Thr Ile 
                405                 410                 415     


Met Lys Leu Asp Ser Phe Val Leu Asn Leu Ile Thr Asn Gln Ile Phe 
            420                 425                 430         


Lys Ala Asn Asn Lys Ser Ile Glu Ile Ile Glu Ser Leu Ser Thr Leu 
        435                 440                 445             


Cys Leu Trp Tyr Asn Phe Phe Glu Trp Ser Ser Lys Thr Arg Tyr His 
    450                 455                 460                 


Ile Phe Asn Tyr Ile Cys Cys Cys Leu Thr Arg Asp Leu Gly Pro Thr 
465                 470                 475                 480 


Tyr Val Asn Arg Ser Phe Gly Met Phe Ser Asp Glu Asp Pro Lys Arg 
                485                 490                 495     


Phe Lys Ser Pro Leu Glu Leu Tyr Ser Asn Gly Ala Ser Leu Thr Leu 
            500                 505                 510         


Leu Val Tyr Ile Ser Ala Leu Asn Ile Ser Ile Phe Leu Arg Gln Ser 
        515                 520                 525             


Ile Gln Ala Arg Trp Ser His Val Thr Glu Lys Ala Cys Glu Asp Leu 
    530                 535                 540                 


Val Lys Glu Thr Lys Lys Ser Arg His Tyr Asp Asn Asp Lys Leu Leu 
545                 550                 555                 560 


Leu Asp Ser Ala Asp Asp Pro Ile Leu Val Gln Phe Ala Lys Met Asn 
                565                 570                 575     


His Val Leu Glu Asn Ile His Thr His Leu His Glu Arg Asp Leu Asn 
            580                 585                 590         


Asp Asp Glu Phe Asp Asp Pro Ile Phe Thr Lys Lys Tyr Leu Asn Lys 
        595                 600                 605             


Leu Met Glu Lys Tyr His Lys Gln Leu Gln Glu Ile Phe Thr Lys Leu 
    610                 615                 620                 


Asp Arg Asn Arg Pro Arg Val Ile Ala Phe Tyr Tyr Ser Val Glu Ala 
625                 630                 635                 640 


Tyr Leu Tyr Gln Tyr Lys Leu Ala Val Phe Ile Gly Glu Met Ser His 
                645                 650                 655     


Thr Ile Asn Glu Lys Val Glu Leu Pro Arg Glu Ile Met Asp Asp Phe 
            660                 665                 670         


Val Lys Cys Tyr His Cys Cys Lys Ser Ala Leu Glu Glu Phe Ser Lys 
        675                 680                 685             


Leu Glu Pro Ile Leu Ile Thr Ser Leu Pro Leu Phe His Thr Ser Arg 
    690                 695                 700                 


Ile Ile Tyr Thr Val Gly Met Leu Leu Leu Lys Leu Arg Tyr Ser Val 
705                 710                 715                 720 


Val Ala Ile Pro Ser Phe His Asp Leu Met Pro Leu Thr Asp Asp Ala 
                725                 730                 735     


Ile Ala Leu Val Ile Gly Val Asn Asn Leu Leu Glu Lys Thr Ser Glu 
            740                 745                 750         


Leu Tyr Pro Phe Asn Asn Ser Leu Tyr Lys Phe Arg Tyr Val Ile Ala 
        755                 760                 765             


Leu Phe Cys Gln Thr Tyr Ala Asn Lys Val Ile Asp Val Ala Asp Arg 
    770                 775                 780                 


Tyr Asn Ala Glu Arg Glu Lys Leu Lys Glu Lys Gln Val Ile Asp Glu 
785                 790                 795                 800 


Val Ser Asn Gly His Asp Gly Thr Lys Pro Ile Asn Ala Tyr Val Thr 
                805                 810                 815     


Glu Ser Gln Lys Met Pro Thr Glu Glu Asp Pro Ile Ile Asp Asn Asn 
            820                 825                 830         


Thr Asn Gln Asn Ile Thr Ala Val Pro Asp Glu Met Leu Pro Val Tyr 
        835                 840                 845             


Ser Arg Val Arg Asp Asp Thr Ala Ala Met Asn Leu Asn Ile Asn Ser 
    850                 855                 860                 


Thr Ser Tyr Met Asn Glu Ser Pro His Glu His Arg Glu Ser Met Thr 
865                 870                 875                 880 


Gly Thr Thr Leu Leu Pro Pro Pro Phe Ile Ser Asn Asp Val Thr Asn 
                885                 890                 895     


Ser Ala Asp Ser Thr Asn Ile Lys Pro Ser Pro Ser Ser Ser Val Asp 
            900                 905                 910         


Asn Leu Asn Asp Tyr Leu Thr Asp Ile Asn Ser Leu Ala Trp Gly Val 
        915                 920                 925             


Asn Ser Leu Asn Asp Glu Phe Trp Thr Asp Leu Phe Met Asn Asp Ile 
    930                 935                 940                 


<210>  32
<211>  438
<212>  PRT
<213>  Schizosaccharomyces pombe

<400>  32

Met Gly Glu Leu Lys Glu Ile Leu Lys Gln Arg Tyr His Glu Leu Leu 
1               5                   10                  15      


Asp Trp Asn Val Lys Ala Pro His Val Pro Leu Ser Gln Arg Leu Lys 
            20                  25                  30          


His Phe Thr Trp Ser Trp Phe Ala Cys Thr Met Ala Thr Gly Gly Val 
        35                  40                  45              


Gly Leu Ile Ile Gly Ser Phe Pro Phe Arg Phe Tyr Gly Leu Asn Thr 
    50                  55                  60                  


Ile Gly Lys Ile Val Tyr Ile Leu Gln Ile Phe Leu Phe Ser Leu Phe 
65                  70                  75                  80  


Gly Ser Cys Met Leu Phe Arg Phe Ile Lys Tyr Pro Ser Thr Ile Lys 
                85                  90                  95      


Asp Ser Trp Asn His His Leu Glu Lys Leu Phe Ile Ala Thr Cys Leu 
            100                 105                 110         


Leu Ser Ile Ser Thr Phe Ile Asp Met Leu Ala Ile Tyr Ala Tyr Pro 
        115                 120                 125             


Asp Thr Gly Glu Trp Met Val Trp Val Ile Arg Ile Leu Tyr Tyr Ile 
    130                 135                 140                 


Tyr Val Ala Val Ser Phe Ile Tyr Cys Val Met Ala Phe Phe Thr Ile 
145                 150                 155                 160 


Phe Asn Asn His Val Tyr Thr Ile Glu Thr Ala Ser Pro Ala Trp Ile 
                165                 170                 175     


Leu Pro Ile Phe Pro Pro Met Ile Cys Gly Val Ile Ala Gly Ala Val 
            180                 185                 190         


Asn Ser Thr Gln Pro Ala His Gln Leu Lys Asn Met Val Ile Phe Gly 
        195                 200                 205             


Ile Leu Phe Gln Gly Leu Gly Phe Trp Val Tyr Leu Leu Leu Phe Ala 
    210                 215                 220                 


Val Asn Val Leu Arg Phe Phe Thr Val Gly Leu Ala Lys Pro Gln Asp 
225                 230                 235                 240 


Arg Pro Gly Met Phe Met Phe Val Gly Pro Pro Ala Phe Ser Gly Leu 
                245                 250                 255     


Ala Leu Ile Asn Ile Ala Arg Gly Ala Met Gly Ser Arg Pro Tyr Ile 
            260                 265                 270         


Phe Val Gly Ala Asn Ser Ser Glu Tyr Leu Gly Phe Val Ser Thr Phe 
        275                 280                 285             


Met Ala Ile Phe Ile Trp Gly Leu Ala Ala Trp Cys Tyr Cys Leu Ala 
    290                 295                 300                 


Met Val Ser Phe Leu Ala Gly Phe Phe Thr Arg Ala Pro Leu Lys Phe 
305                 310                 315                 320 


Ala Cys Gly Trp Phe Ala Phe Ile Phe Pro Asn Val Gly Phe Val Asn 
                325                 330                 335     


Cys Thr Ile Glu Ile Gly Lys Met Ile Asp Ser Lys Ala Phe Gln Met 
            340                 345                 350         


Phe Gly His Ile Ile Gly Val Ile Leu Cys Ile Gln Trp Ile Leu Leu 
        355                 360                 365             


Met Tyr Leu Met Val Arg Ala Phe Leu Val Asn Asp Leu Cys Tyr Pro 
    370                 375                 380                 


Gly Lys Asp Glu Asp Ala His Pro Pro Pro Lys Pro Asn Thr Gly Val 
385                 390                 395                 400 


Leu Asn Pro Thr Phe Pro Pro Glu Lys Ala Pro Ala Ser Leu Glu Lys 
                405                 410                 415     


Val Asp Thr His Val Thr Ser Thr Gly Gly Glu Ser Asp Pro Pro Ser 
            420                 425                 430         


Ser Glu His Glu Ser Val 
        435             


<210>  33
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  33

Met Leu His Ile Ala Met Ile Gly Cys Gly Ala Ile Gly Ala Gly Val 
1               5                   10                  15      


Leu Glu Leu Leu Lys Ser Asp Pro Asp Leu Arg Val Asp Ala Val Ile 
            20                  25                  30          


Val Pro Glu Glu Ser Met Asp Ala Val Arg Glu Ala Val Ala Ala Leu 
        35                  40                  45              


Ala Pro Val Ala Arg Val Leu Thr Ala Leu Pro Ala Asp Ala Arg Pro 
    50                  55                  60                  


Asp Leu Leu Val Glu Cys Ala Gly His Arg Ala Ile Glu Glu His Val 
65                  70                  75                  80  


Val Pro Ala Leu Glu Arg Gly Ile Pro Cys Ala Val Ala Ser Val Gly 
                85                  90                  95      


Ala Leu Ser Glu Pro Gly Leu Ala Glu Arg Leu Glu Ala Ala Ala Arg 
            100                 105                 110         


Arg Gly Gly Thr Gln Val Gln Leu Leu Ser Gly Ala Ile Gly Ala Ile 
        115                 120                 125             


Asp Ala Leu Ala Ala Ala Arg Val Gly Gly Leu Asp Ser Val Val Tyr 
    130                 135                 140                 


Thr Gly Arg Lys Pro Pro Leu Ala Trp Lys Gly Thr Pro Ala Glu Gln 
145                 150                 155                 160 


Val Cys Asp Leu Asp Ala Leu Thr Glu Ala Thr Val Ile Phe Glu Gly 
                165                 170                 175     


Ser Ala Arg Glu Ala Ala Arg Leu Tyr Pro Lys Asn Ala Asn Val Ala 
            180                 185                 190         


Ala Thr Leu Ser Leu Ala Gly Leu Gly Leu Asp Arg Thr Gln Val Arg 
        195                 200                 205             


Leu Ile Ala Asp Pro Ala Val Thr Glu Asn Val His His Val Glu Ala 
    210                 215                 220                 


Arg Gly Ala Phe Gly Gly Phe Glu Leu Thr Met Arg Gly Lys Pro Leu 
225                 230                 235                 240 


Ala Ala Asn Pro Lys Thr Ser Ala Leu Thr Val Tyr Ser Val Val Arg 
                245                 250                 255     


Ala Leu Gly Asn Arg Ala His Ala Leu Ser Ile 
            260                 265         


<210>  34
<211>  267
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  34

Met Leu Asn Ile Val Met Ile Gly Cys Gly Ala Ile Gly Ala Gly Val 
1               5                   10                  15      


Leu Glu Leu Leu Glu Asn Asp Pro Gln Leu Arg Val Asp Ala Val Ile 
            20                  25                  30          


Val Pro Arg Asp Ser Glu Thr Gln Val Arg His Arg Leu Ala Ser Leu 
        35                  40                  45              


Arg Arg Pro Pro Arg Val Leu Ser Ala Leu Pro Ala Gly Glu Arg Pro 
    50                  55                  60                  


Asp Leu Leu Val Glu Cys Ala Gly His Arg Ala Ile Glu Gln His Val 
65                  70                  75                  80  


Leu Pro Ala Leu Ala Gln Gly Ile Pro Cys Leu Val Val Ser Val Gly 
                85                  90                  95      


Ala Leu Ser Glu Pro Gly Leu Val Glu Arg Leu Glu Ala Ala Ala Gln 
            100                 105                 110         


Ala Gly Gly Ser Arg Ile Glu Leu Leu Pro Gly Ala Ile Gly Ala Ile 
        115                 120                 125             


Asp Ala Leu Ser Ala Ala Arg Val Gly Gly Leu Glu Ser Val Arg Tyr 
    130                 135                 140                 


Thr Gly Arg Lys Pro Ala Ser Ala Trp Leu Gly Thr Pro Gly Glu Thr 
145                 150                 155                 160 


Val Cys Asp Leu Gln Arg Leu Glu Lys Ala Arg Val Ile Phe Asp Gly 
                165                 170                 175     


Ser Ala Arg Glu Ala Ala Arg Leu Tyr Pro Lys Asn Ala Asn Val Ala 
            180                 185                 190         


Ala Thr Leu Ser Leu Ala Gly Leu Gly Leu Asp Arg Thr Gln Val Arg 
        195                 200                 205             


Leu Ile Ala Asp Pro Glu Ser Cys Glu Asn Val His Gln Val Glu Ala 
    210                 215                 220                 


Ser Gly Ala Phe Gly Gly Phe Glu Leu Thr Leu Arg Gly Lys Pro Leu 
225                 230                 235                 240 


Ala Ala Asn Pro Lys Thr Ser Ala Leu Thr Val Tyr Ser Val Val Arg 
                245                 250                 255     


Ala Leu Gly Asn His Ala His Ala Ile Ser Ile 
            260                 265         


<210>  35
<211>  885
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  35

Met Asn Glu Gln Tyr Ser Ala Leu Arg Ser Asn Val Ser Met Leu Gly 
1               5                   10                  15      


Lys Leu Leu Gly Asp Thr Ile Lys Asp Ala Leu Gly Glu Asp Ile Leu 
            20                  25                  30          


Asp Arg Val Glu Thr Ile Arg Lys Leu Ser Lys Ser Ser Arg Ala Gly 
        35                  40                  45              


Asn Glu Ala Asn Arg Gln Glu Leu Leu Thr Thr Leu Gln Asn Leu Ser 
    50                  55                  60                  


Asn Asp Glu Leu Leu Pro Val Ala Arg Ala Phe Ser Gln Phe Leu Asn 
65                  70                  75                  80  


Leu Thr Asn Thr Ala Glu Gln Tyr His Ser Ile Ser Pro His Gly Glu 
                85                  90                  95      


Ala His Ala Ser Asn Pro Glu Ala Ile Ala Arg Leu Phe Arg Lys Leu 
            100                 105                 110         


Lys Asp Gln Pro Asn Leu Ser Glu Ala Asp Ile Lys Lys Ala Val Glu 
        115                 120                 125             


Ser Leu Ser Ile Glu Leu Val Leu Thr Ala His Pro Thr Glu Ile Thr 
    130                 135                 140                 


Arg Arg Thr Leu Ile His Lys Leu Val Glu Val Asn Thr Cys Leu Ser 
145                 150                 155                 160 


Gln Leu Asp His Asp Asp Leu Ala Asp Tyr Glu Arg Asn Gln Ile Met 
                165                 170                 175     


Arg Arg Leu Arg Gln Leu Ile Ala Gln Ser Trp His Thr Asp Glu Ile 
            180                 185                 190         


Arg Lys Gln Arg Pro Thr Pro Val Asp Glu Ala Lys Trp Gly Phe Ala 
        195                 200                 205             


Val Val Glu Asn Ser Leu Trp Glu Gly Val Pro Ala Phe Leu Arg Glu 
    210                 215                 220                 


Phe Asn Glu Gln Leu Glu Glu Ser Leu Gly Tyr Lys Leu Pro Val Glu 
225                 230                 235                 240 


Ala Val Pro Val Arg Phe Thr Ser Trp Met Gly Gly Asp Arg Asp Gly 
                245                 250                 255     


Asn Pro Asn Val Thr Ala Glu Ile Thr Arg His Val Leu Leu Leu Ser 
            260                 265                 270         


Arg Trp Lys Ala Ala Asp Leu Phe Leu Lys Asp Ile Gln Val Leu Val 
        275                 280                 285             


Ser Glu Leu Ser Met Val Glu Cys Thr Pro Glu Leu Arg Ala Leu Ala 
    290                 295                 300                 


Gly Glu Glu Gly Ala Leu Glu Pro Tyr Arg Glu Leu Leu Lys Asn Leu 
305                 310                 315                 320 


Arg Thr Gln Leu Met Ala Thr Leu Ala Tyr Leu Glu Ala Arg Leu Lys 
                325                 330                 335     


Gly Glu Arg Leu Arg Pro Lys Pro Ala Gly Leu Leu Thr Gln Asn Glu 
            340                 345                 350         


Gln Leu Trp Glu Pro Leu Tyr Ala Cys Tyr Gln Ser Leu Gln Ala Cys 
        355                 360                 365             


Gly Met Gly Ile Ile Ala Asn Gly Gln Leu Leu Asp Thr Leu Arg Arg 
    370                 375                 380                 


Val Lys Cys Phe Gly Val Pro Leu Val Arg Ile Asp Ile Arg Gln Glu 
385                 390                 395                 400 


Ser Thr Arg His Thr Glu Ala Leu Ala Glu Leu Thr Arg Tyr Leu Gly 
                405                 410                 415     


Leu Gly Asp Tyr Glu Ser Trp Ser Glu Ala Asp Lys Gln Ala Phe Leu 
            420                 425                 430         


Ile Arg Glu Leu Asn Ser Lys Arg Pro Leu Leu Pro Arg Asn Trp Glu 
        435                 440                 445             


Pro Ser Ala Glu Thr Gln Glu Val Leu Asp Thr Cys Lys Val Ile Ala 
    450                 455                 460                 


Glu Ala Pro Lys Gly Ser Ile Ala Ala Tyr Val Ile Ser Met Ala Lys 
465                 470                 475                 480 


Thr Pro Ser Asp Val Leu Ala Val His Leu Leu Leu Lys Glu Ala Gly 
                485                 490                 495     


Cys Pro Phe Ala Leu Pro Val Ala Pro Leu Phe Glu Thr Leu Asp Asp 
            500                 505                 510         


Leu Asn Asn Ala Glu Asp Val Met Thr Gln Leu Leu Asn Ile Asp Trp 
        515                 520                 525             


Tyr Arg Gly Phe Ile Gln Gly Lys Gln Met Val Met Ile Gly Tyr Ser 
    530                 535                 540                 


Asp Ser Ala Lys Asp Ala Gly Val Met Ala Ala Ser Trp Ala Gln Tyr 
545                 550                 555                 560 


Arg Ala Gln Asp Ala Leu Ile Lys Thr Cys Glu Lys Ala Gly Ile Glu 
                565                 570                 575     


Leu Thr Leu Phe His Gly Arg Gly Gly Ser Ile Gly Arg Gly Gly Ala 
            580                 585                 590         


Pro Ala His Ala Ala Leu Leu Ser Gln Pro Pro Gly Ser Leu Lys Gly 
        595                 600                 605             


Gly Leu Arg Val Thr Glu Gln Gly Glu Met Ile Arg Phe Lys Leu Gly 
    610                 615                 620                 


Leu Pro Glu Val Thr Val Ser Ser Leu Ser Leu Tyr Ala Ser Ala Ile 
625                 630                 635                 640 


Leu Glu Ala Asn Leu Leu Pro Pro Pro Glu Pro Lys Asp Glu Trp Arg 
                645                 650                 655     


Asp Ile Met Asp Glu Leu Ser Asp Ile Ser Cys Asp Leu Tyr Arg Gly 
            660                 665                 670         


Tyr Val Arg Glu Asn Lys Asp Phe Val Pro Tyr Phe Arg Ala Ala Thr 
        675                 680                 685             


Pro Glu Gln Glu Leu Gly Lys Leu Pro Leu Gly Ser Arg Pro Ala Lys 
    690                 695                 700                 


Arg Arg Pro Thr Gly Gly Val Glu Ser Leu Arg Ala Ile Pro Trp Ile 
705                 710                 715                 720 


Phe Ala Trp Thr Gln Asn Arg Leu Met Leu Pro Ala Trp Leu Gly Ala 
                725                 730                 735     


Gly Ala Ala Leu Gln Lys Val Ile Glu Asp Gly Lys Gln Asp Glu Leu 
            740                 745                 750         


Glu Ala Met Cys Arg Asp Trp Pro Phe Phe Ser Thr Arg Ile Gly Met 
        755                 760                 765             


Leu Glu Met Val Phe Ala Lys Ala Asp Leu Trp Leu Ala Glu Tyr Tyr 
    770                 775                 780                 


Asp Gln Arg Leu Val Asp Lys Ala Leu Trp Pro Leu Gly Glu Glu Leu 
785                 790                 795                 800 


Arg Asp Gln Leu Glu Glu Asp Ile Lys Val Val Leu Ala Ile Ala Asn 
                805                 810                 815     


Asp Ser His Leu Met Ala Asp Leu Pro Trp Ile Ala Glu Ser Ile Ala 
            820                 825                 830         


Leu Arg Asn Val Tyr Thr Asp Pro Leu Asn Val Leu Gln Ala Glu Leu 
        835                 840                 845             


Leu His Arg Ser Arg Gln Gln Glu Glu Glu Gly Lys Glu Pro Asp Pro 
    850                 855                 860                 


Arg Val Glu Gln Ala Leu Met Val Thr Ile Ala Gly Ile Ala Ala Gly 
865                 870                 875                 880 


Met Arg Asn Thr Gly 
                885 


<210>  36
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  36

Met Ser Leu Gln Asp Phe Asp Ala Asp Glu Leu Ala Ala Phe His Glu 
1               5                   10                  15      


Asp Ile Lys Ala Ala Tyr Glu Glu Leu Lys Ala Lys Asn Leu Lys Leu 
            20                  25                  30          


Asp Leu Thr Arg Gly Lys Pro Ser Ser Glu Gln Leu Asp Phe Ser Asn 
        35                  40                  45              


Glu Leu Leu Ala Leu Pro Gly Glu Asp Asp Tyr Arg Asp Ala Asp Gly 
    50                  55                  60                  


Thr Asp Thr Arg Asn Tyr Gly Gly Leu Thr Gly Ile Pro Glu Ile Arg 
65                  70                  75                  80  


Ala Ile Trp Ala Glu Leu Leu Gly Ile Pro Val Glu Asn Val Leu Ala 
                85                  90                  95      


Gly Asp Ala Ser Ser Leu Asn Ile Met Phe Asp Leu Ile Ser Trp Ser 
            100                 105                 110         


Tyr Leu Phe Gly Asn Asn Asp Ser Pro Arg Pro Trp Ser Gln Glu Glu 
        115                 120                 125             


Val Val Lys Trp Leu Cys Pro Val Pro Gly Tyr Asp Arg His Phe Ala 
    130                 135                 140                 


Ile Thr Glu Ser Phe Gly Ile Glu Met Ile Pro Val Pro Leu Arg Glu 
145                 150                 155                 160 


Asp Gly Pro Asp Met Asp Ala Val Glu Glu Leu Val Ala Lys Asp Pro 
                165                 170                 175     


Gln Ile Lys Gly Met Trp Thr Val Pro Val Phe Ser Asn Pro Thr Gly 
            180                 185                 190         


Ala Thr Tyr Ser Glu Glu Val Ala Arg Arg Leu Ala Glu Met Glu Thr 
        195                 200                 205             


Ala Ala Pro Asp Phe Arg Ile Val Trp Asp Asn Ala Tyr Ala Val His 
    210                 215                 220                 


Thr Leu Thr Asp Glu Phe Pro Glu Val Ile Asp Ile Leu Gly Leu Ala 
225                 230                 235                 240 


Glu Ala Ala Gly Asn 
                245 


<210>  37
<211>  127
<212>  PRT
<213>  Bacillus subtilis

<400>  37

Met Tyr Arg Thr Met Met Ser Gly Lys Leu His Arg Ala Thr Val Thr 
1               5                   10                  15      


Glu Ala Asn Leu Asn Tyr Val Gly Ser Ile Thr Ile Asp Glu Asp Leu 
            20                  25                  30          


Ile Asp Ala Val Gly Met Leu Pro Asn Glu Lys Val Gln Ile Val Asn 
        35                  40                  45              


Asn Asn Asn Gly Ala Arg Leu Glu Thr Tyr Ile Ile Pro Gly Lys Arg 
    50                  55                  60                  


Gly Ser Gly Val Ile Cys Leu Asn Gly Ala Ala Ala Arg Leu Val Gln 
65                  70                  75                  80  


Glu Gly Asp Lys Val Ile Ile Ile Ser Tyr Lys Met Met Ser Asp Gln 
                85                  90                  95      


Glu Ala Ala Ser His Glu Pro Lys Val Ala Val Leu Asn Asp Gln Asn 
            100                 105                 110         


Lys Ile Glu Gln Met Leu Gly Asn Glu Pro Ala Arg Thr Ile Leu 
        115                 120                 125         


<210>  38
<211>  540
<212>  PRT
<213>  Tribolium castaneum

<400>  38

Met Pro Ala Thr Gly Glu Asp Gln Asp Leu Val Gln Asp Leu Ile Glu 
1               5                   10                  15      


Glu Pro Ala Thr Phe Ser Asp Ala Val Leu Ser Ser Asp Glu Glu Leu 
            20                  25                  30          


Phe His Gln Lys Cys Pro Lys Pro Ala Pro Ile Tyr Ser Pro Ile Ser 
        35                  40                  45              


Lys Pro Val Ser Phe Glu Ser Leu Pro Asn Arg Arg Leu His Glu Glu 
    50                  55                  60                  


Phe Leu Arg Ser Ser Val Asp Val Leu Leu Gln Glu Ala Val Phe Glu 
65                  70                  75                  80  


Gly Thr Asn Arg Lys Asn Arg Val Leu Gln Trp Arg Glu Pro Glu Glu 
                85                  90                  95      


Leu Arg Arg Leu Met Asp Phe Gly Val Arg Gly Ala Pro Ser Thr His 
            100                 105                 110         


Glu Glu Leu Leu Glu Val Leu Lys Lys Val Val Thr Tyr Ser Val Lys 
        115                 120                 125             


Thr Gly His Pro Tyr Phe Val Asn Gln Leu Phe Ser Ala Val Asp Pro 
    130                 135                 140                 


Tyr Gly Leu Val Ala Gln Trp Ala Thr Asp Ala Leu Asn Pro Ser Val 
145                 150                 155                 160 


Tyr Thr Tyr Glu Val Ser Pro Val Phe Val Leu Met Glu Glu Val Val 
                165                 170                 175     


Leu Arg Glu Met Arg Ala Ile Val Gly Phe Glu Gly Gly Lys Gly Asp 
            180                 185                 190         


Gly Ile Phe Cys Pro Gly Gly Ser Ile Ala Asn Gly Tyr Ala Ile Ser 
        195                 200                 205             


Cys Ala Arg Tyr Arg Phe Met Pro Asp Ile Lys Lys Lys Gly Leu His 
    210                 215                 220                 


Ser Leu Pro Arg Leu Val Leu Phe Thr Ser Glu Asp Ala His Tyr Ser 
225                 230                 235                 240 


Ile Lys Lys Leu Ala Ser Phe Glu Gly Ile Gly Thr Asp Asn Val Tyr 
                245                 250                 255     


Leu Ile Arg Thr Asp Ala Arg Gly Arg Met Asp Val Ser His Leu Val 
            260                 265                 270         


Glu Glu Ile Glu Arg Ser Leu Arg Glu Gly Ala Ala Pro Phe Met Val 
        275                 280                 285             


Ser Ala Thr Ala Gly Thr Thr Val Ile Gly Ala Phe Asp Pro Ile Glu 
    290                 295                 300                 


Lys Ile Ala Asp Val Cys Gln Lys Tyr Lys Leu Trp Leu His Val Asp 
305                 310                 315                 320 


Ala Ala Trp Gly Gly Gly Ala Leu Val Ser Ala Lys His Arg His Leu 
                325                 330                 335     


Leu Lys Gly Ile Glu Arg Ala Asp Ser Val Thr Trp Asn Pro His Lys 
            340                 345                 350         


Leu Leu Thr Ala Pro Gln Gln Cys Ser Thr Leu Leu Leu Arg His Glu 
        355                 360                 365             


Gly Val Leu Ala Glu Ala His Ser Thr Asn Ala Ala Tyr Leu Phe Gln 
    370                 375                 380                 


Lys Asp Lys Phe Tyr Asp Thr Lys Tyr Asp Thr Gly Asp Lys His Ile 
385                 390                 395                 400 


Gln Cys Gly Arg Arg Ala Asp Val Leu Lys Phe Trp Phe Met Trp Lys 
                405                 410                 415     


Ala Lys Gly Thr Ser Gly Leu Glu Lys His Val Asp Lys Val Phe Glu 
            420                 425                 430         


Asn Ala Arg Phe Phe Thr Asp Cys Ile Lys Asn Arg Glu Gly Phe Glu 
        435                 440                 445             


Met Val Ile Ala Glu Pro Glu Tyr Thr Asn Ile Cys Phe Trp Tyr Val 
    450                 455                 460                 


Pro Lys Ser Leu Arg Gly Arg Lys Asp Glu Ala Asp Tyr Lys Asp Lys 
465                 470                 475                 480 


Leu His Lys Val Ala Pro Arg Ile Lys Glu Arg Met Met Lys Glu Gly 
                485                 490                 495     


Ser Met Met Val Thr Tyr Gln Ala Gln Lys Gly His Pro Asn Phe Phe 
            500                 505                 510         


Arg Ile Val Phe Gln Asn Ser Gly Leu Asp Lys Ala Asp Met Val His 
        515                 520                 525             


Phe Val Glu Glu Ile Glu Arg Leu Gly Ser Asp Leu 
    530                 535                 540 


<210>  39
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  39

Met Leu Arg Thr Met Leu Lys Ser Lys Ile His Arg Ala Thr Val Thr 
1               5                   10                  15      


Gln Ala Asp Leu His Tyr Val Gly Ser Val Thr Ile Asp Ala Asp Leu 
            20                  25                  30          


Leu Asp Ala Ala Asp Ile Leu Glu Gly Glu Lys Val Ala Ile Val Asp 
        35                  40                  45              


Ile Thr Asn Gly Ala Arg Leu Glu Thr Tyr Val Ile Ala Gly Glu Arg 
    50                  55                  60                  


Gly Ser Gly Val Ile Gly Ile Asn Gly Ala Ala Ala His Leu Val His 
65                  70                  75                  80  


Pro Gly Asp Leu Val Ile Ile Ile Ala Tyr Ala Gln Met Ser Asp Ala 
                85                  90                  95      


Glu Ala Arg Ala Tyr Glu Pro Arg Val Val Phe Val Asp Ala Asp Asn 
            100                 105                 110         


Arg Ile Val Glu Leu Gly Asn Asp Pro Ala Glu Ala Leu Pro Gly Gly 
        115                 120                 125             


<210>  40
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  40

Met Pro Ala Asn Gly Asn Phe Pro Val Ala Leu Glu Val Ile Ser Ile 
1               5                   10                  15      


Phe Lys Pro Tyr Asn Ser Ala Val Glu Asp Leu Ala Ser Met Ala Lys 
            20                  25                  30          


Thr Asp Thr Ser Ala Ser Ser Ser Gly Ser Asp Ser Ala Gly Ser Ser 
        35                  40                  45              


Glu Asp Glu Asp Val Gln Leu Phe Ala Ser Lys Gly Asn Leu Leu Asn 
    50                  55                  60                  


Ser Lys Leu Leu Lys Lys Ser Asn Asn Asn Asn Lys Asn Asn Asn Ile 
65                  70                  75                  80  


Asn Glu Asn Asn Asn Lys Asn Ala Ala Ala Gly Leu Lys Arg Phe Ala 
                85                  90                  95      


Ser Leu Pro Asn Arg Ala Glu His Glu Glu Phe Leu Arg Asp Cys Val 
            100                 105                 110         


Asp Glu Ile Leu Lys Leu Ala Val Phe Glu Gly Thr Asn Arg Ser Ser 
        115                 120                 125             


Lys Val Val Glu Trp His Asp Pro Glu Glu Leu Lys Lys Leu Phe Asp 
    130                 135                 140                 


Phe Glu Leu Arg Ala Glu Pro Asp Ser His Glu Lys Leu Leu Glu Leu 
145                 150                 155                 160 


Leu Arg Ala Thr Ile Arg Tyr Ser Val Lys Thr Gly His Pro Tyr Phe 
                165                 170                 175     


Val Asn Gln Leu Phe Ser Ser Val Asp Pro Tyr Gly Leu Val Gly Gln 
            180                 185                 190         


Trp Leu Thr Asp Ala Leu Asn Pro Ser Val Tyr Thr Tyr Glu Val Ala 
        195                 200                 205             


Pro Val Phe Thr Leu Met Glu Glu Val Val Leu Arg Glu Met Arg Arg 
    210                 215                 220                 


Ile Val Gly Phe Pro Asn Asp Gly Glu Gly Asp Gly Ile Phe Cys Pro 
225                 230                 235                 240 


Gly Gly Ser Ile Ala Asn Gly Tyr Ala Ile Ser Cys Ala Arg Tyr Lys 
                245                 250                 255     


Tyr Ala Pro Glu Val Lys Lys Lys Gly Leu His Ser Leu Pro Arg Leu 
            260                 265                 270         


Val Ile Phe Thr Ser Glu Asp Ala His Tyr Ser Val Lys Lys Leu Ala 
        275                 280                 285             


Ser Phe Met Gly Ile Gly Ser Asp Asn Val Tyr Lys Ile Ala Thr Asp 
    290                 295                 300                 


Glu Val Gly Lys Met Arg Val Ser Asp Leu Glu Gln Glu Ile Leu Arg 
305                 310                 315                 320 


Ala Leu Asp Glu Gly Ala Gln Pro Phe Met Val Ser Ala Thr Ala Gly 
                325                 330                 335     


Thr Thr Val Ile Gly Ala Phe Asp Pro Leu Glu Gly Ile Ala Asp Leu 
            340                 345                 350         


Cys Lys Lys Tyr Asn Leu Trp Met His Val Asp Ala Ala Trp Gly Gly 
        355                 360                 365             


Gly Ala Leu Met Ser Lys Lys Tyr Arg His Leu Leu Lys Gly Ile Glu 
    370                 375                 380                 


Arg Ala Asp Ser Val Thr Trp Asn Pro His Lys Leu Leu Ala Ala Pro 
385                 390                 395                 400 


Gln Gln Cys Ser Thr Phe Leu Thr Arg His Glu Gly Ile Leu Ser Glu 
                405                 410                 415     


Cys His Ser Thr Asn Ala Thr Tyr Leu Phe Gln Lys Asp Lys Phe Tyr 
            420                 425                 430         


Asp Thr Ser Tyr Asp Thr Gly Asp Lys His Ile Gln Cys Gly Arg Arg 
        435                 440                 445             


Ala Asp Val Leu Lys Phe Trp Phe Met Trp Lys Ala Lys Gly Thr Ser 
    450                 455                 460                 


Gly Phe Glu Ala His Val Asp Lys Val Phe Glu Asn Ala Glu Tyr Phe 
465                 470                 475                 480 


Thr Asp Ser Ile Lys Ala Arg Pro Gly Phe Glu Leu Val Ile Glu Glu 
                485                 490                 495     


Pro Glu Cys Thr Asn Ile Cys Phe Trp Tyr Val Pro Pro Ser Leu Arg 
            500                 505                 510         


Gly Met Glu Arg Asp Asn Ala Glu Phe Tyr Glu Lys Leu His Lys Val 
        515                 520                 525             


Ala Pro Lys Ile Lys Glu Arg Met Ile Lys Glu Gly Ser Met Met Ile 
    530                 535                 540                 


Thr Tyr Gln Pro Leu Arg Asp Leu Pro Asn Phe Phe Arg Leu Val Leu 
545                 550                 555                 560 


Gln Asn Ser Gly Leu Asp Lys Ser Asp Met Leu Tyr Phe Ile Asn Glu 
                565                 570                 575     


Ile Glu Arg Leu Gly Ser Asp Leu Val 
            580                 585 


<210>  41
<211>  273
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  41

Met Leu Ser Gly Asn Gly Gln Leu Asp Ala Asn Lys Trp Thr Pro Phe 
1               5                   10                  15      


Ile Asn Ser Gln Thr Trp Thr Thr Tyr Ile Leu Pro Gly Leu Trp Gly 
            20                  25                  30          


Thr Leu Lys Ser Ala Val Phe Ser Val Ile Leu Ala Leu Val Met Gly 
        35                  40                  45              


Thr Ala Leu Gly Leu Gly Arg Ile Ser Glu Ile Arg Ile Leu Arg Trp 
    50                  55                  60                  


Phe Cys Ala Val Ile Ile Glu Thr Phe Arg Ala Ile Pro Val Leu Ile 
65                  70                  75                  80  


Leu Met Ile Phe Ala Tyr Gln Met Phe Ala Gln Tyr Asn Ile Val Pro 
                85                  90                  95      


Ser Ser Gln Leu Ala Phe Ala Ala Val Val Phe Gly Leu Thr Met Tyr 
            100                 105                 110         


Asn Gly Ser Val Ile Ala Glu Ile Leu Arg Ser Gly Ile Ala Ser Leu 
        115                 120                 125             


Pro Lys Gly Gln Lys Glu Ala Ala Ile Ala Leu Gly Met Ser Ser Arg 
    130                 135                 140                 


Gln Thr Thr Trp Ser Ile Leu Leu Pro Gln Ala Val Ala Ala Met Leu 
145                 150                 155                 160 


Pro Ala Leu Ile Ser Gln Met Val Ile Ala Leu Lys Asp Ser Ala Leu 
                165                 170                 175     


Gly Tyr Gln Ile Gly Tyr Ile Glu Val Val Arg Ser Gly Ile Gln Ser 
            180                 185                 190         


Ala Ser Val Asn Arg Asn Tyr Leu Ala Ala Leu Phe Val Val Ala Leu 
        195                 200                 205             


Ile Met Ile Val Leu Asn Phe Ser Leu Thr Ala Leu Ala Ser Arg Ile 
    210                 215                 220                 


Glu Arg Gln Leu Arg Ala Gly Arg Ala Arg Lys Asn Ile Val Ala Lys 
225                 230                 235                 240 


Val Pro Glu Gln Pro Asp Gln Gly Leu Glu Thr Lys Asp Asn Val Asn 
                245                 250                 255     


Val Asp Trp Gln Asp Pro Asp Tyr Lys Asp Leu Lys Thr Pro Gly Val 
            260                 265                 270         


Gln 
    


<210>  42
<211>  242
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  42

Met Ile Lys Met Thr Gly Val Gln Lys Tyr Phe Gly Asp Phe His Ala 
1               5                   10                  15      


Leu Thr Asp Ile Asp Leu Glu Ile Pro Arg Gly Gln Val Val Val Val 
            20                  25                  30          


Leu Gly Pro Ser Gly Ser Gly Lys Ser Thr Leu Cys Arg Thr Ile Asn 
        35                  40                  45              


Arg Leu Glu Thr Ile Glu Glu Gly Thr Ile Glu Ile Asp Gly Lys Val 
    50                  55                  60                  


Leu Pro Glu Glu Gly Lys Gly Leu Ala Asn Leu Arg Ala Asp Val Gly 
65                  70                  75                  80  


Met Val Phe Gln Ser Phe Asn Leu Phe Pro His Leu Thr Ile Lys Asp 
                85                  90                  95      


Asn Val Thr Leu Ala Pro Ile Lys Val Arg Lys Met Lys Lys Ser Glu 
            100                 105                 110         


Ala Glu Lys Leu Ala Met Ser Leu Leu Glu Arg Val Gly Ile Ala Asn 
        115                 120                 125             


Gln Ala Asp Lys Tyr Pro Ala Gln Leu Ser Gly Gly Gln Gln Gln Arg 
    130                 135                 140                 


Val Ala Ile Ala Arg Ala Leu Ala Met Asn Pro Lys Ile Met Leu Phe 
145                 150                 155                 160 


Asp Glu Pro Thr Ser Ala Leu Asp Pro Glu Met Val Asn Glu Val Leu 
                165                 170                 175     


Asp Val Met Ala Ser Leu Ala Lys Glu Gly Met Thr Met Val Cys Val 
            180                 185                 190         


Thr His Glu Met Gly Phe Ala Arg Lys Ala Ala Asp Arg Val Leu Phe 
        195                 200                 205             


Met Ala Asp Gly Leu Ile Val Glu Asp Thr Glu Pro Asp Ser Phe Phe 
    210                 215                 220                 


Thr Asn Pro Lys Ser Asp Arg Ala Lys Asp Phe Leu Gly Lys Ile Leu 
225                 230                 235                 240 


Ala His 
        


<210>  43
<211>  228
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  43

Met Ser Thr Leu Trp Ala Asp Leu Gly Pro Ser Leu Leu Pro Ala Phe 
1               5                   10                  15      


Trp Val Thr Ile Lys Leu Thr Ile Tyr Ser Ala Ile Gly Ala Met Ile 
            20                  25                  30          


Phe Gly Thr Ile Leu Thr Thr Met Arg Val Ser Pro Val Lys Ile Leu 
        35                  40                  45              


Arg Thr Leu Ser Thr Ala Tyr Ile Asn Thr Val Arg Asn Thr Pro Leu 
    50                  55                  60                  


Thr Leu Val Val Leu Phe Cys Ser Phe Gly Leu Tyr Gln Asn Leu Gly 
65                  70                  75                  80  


Leu Thr Leu Ala Gly Arg Glu Ser Ser Thr Phe Leu Val Asp Asn Asn 
                85                  90                  95      


Phe Arg Leu Ala Val Leu Gly Phe Ile Leu Tyr Thr Ser Thr Phe Val 
            100                 105                 110         


Ala Glu Ser Leu Arg Ser Gly Ile Asn Thr Val His Phe Gly Gln Ala 
        115                 120                 125             


Glu Ala Ala Arg Ser Leu Gly Leu Gly Phe Gly Ala Thr Phe Arg Ser 
    130                 135                 140                 


Ile Ile Phe Pro Gln Ala Val Arg Ala Ala Ile Val Pro Leu Gly Asn 
145                 150                 155                 160 


Thr Leu Ile Ala Leu Thr Lys Asn Thr Thr Ile Ala Ser Val Ile Gly 
                165                 170                 175     


Val Gly Glu Ala Ser Leu Leu Met Lys Ala Thr Ile Glu Asn His Ala 
            180                 185                 190         


Asn Met Leu Phe Val Val Phe Ala Ile Phe Ala Val Gly Phe Met Ile 
        195                 200                 205             


Leu Thr Leu Pro Met Gly Leu Gly Leu Gly Lys Leu Ser Glu Arg Leu 
    210                 215                 220                 


Ala Val Lys Lys 
225             


<210>  44
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Ser His His Trp Gly Tyr Gly Lys His Asn Gly Pro Glu His Trp 
1               5                   10                  15      


His Lys Asp Phe Pro Ile Ala Lys Gly Glu Arg Gln Ser Pro Val Asp 
            20                  25                  30          


Ile Asp Thr His Thr Ala Lys Tyr Asp Pro Ser Leu Lys Pro Leu Ser 
        35                  40                  45              


Val Ser Tyr Asp Gln Ala Thr Ser Leu Arg Ile Leu Asn Asn Gly His 
    50                  55                  60                  


Ala Phe Asn Val Glu Phe Asp Asp Ser Gln Asp Lys Ala Val Leu Lys 
65                  70                  75                  80  


Gly Gly Pro Leu Asp Gly Thr Tyr Arg Leu Ile Gln Phe His Phe His 
                85                  90                  95      


Trp Gly Ser Leu Asp Gly Gln Gly Ser Glu His Thr Val Asp Lys Lys 
            100                 105                 110         


Lys Tyr Ala Ala Glu Leu His Leu Val His Trp Asn Thr Lys Tyr Gly 
        115                 120                 125             


Asp Phe Gly Lys Ala Val Gln Gln Pro Asp Gly Leu Ala Val Leu Gly 
    130                 135                 140                 


Ile Phe Leu Lys Val Gly Ser Ala Lys Pro Gly Leu Gln Lys Val Val 
145                 150                 155                 160 


Asp Val Leu Asp Ser Ile Lys Thr Lys Gly Lys Ser Ala Asp Phe Thr 
                165                 170                 175     


Asn Phe Asp Pro Arg Gly Leu Leu Pro Glu Ser Leu Asp Tyr Trp Thr 
            180                 185                 190         


Tyr Pro Gly Ser Leu Thr Thr Pro Pro Leu Leu Glu Cys Val Thr Trp 
        195                 200                 205             


Ile Val Leu Lys Glu Pro Ile Ser Val Ser Ser Glu Gln Val Leu Lys 
    210                 215                 220                 


Phe Arg Lys Leu Asn Phe Asn Gly Glu Gly Glu Pro Glu Glu Leu Met 
225                 230                 235                 240 


Val Asp Asn Trp Arg Pro Ala Gln Pro Leu Lys Asn Arg Gln Ile Lys 
                245                 250                 255     


Ala Ser Phe Lys 
            260 


<210>  45
<211>  330
<212>  PRT
<213>  Flaveria bidentis

<400>  45

Met Ser Ala Ala Ser Ala Phe Ala Met Asn Ala Pro Ser Phe Val Asn 
1               5                   10                  15      


Ala Ser Ser Leu Lys Lys Ala Ser Thr Ser Ala Arg Ser Gly Val Leu 
            20                  25                  30          


Ser Ala Arg Phe Thr Cys Asn Ser Ser Ser Ser Ser Ser Ser Ser Ala 
        35                  40                  45              


Thr Pro Pro Ser Leu Ile Arg Asn Glu Pro Val Phe Ala Ala Pro Ala 
    50                  55                  60                  


Pro Ile Ile Thr Pro Asn Trp Thr Glu Asp Gly Asn Glu Ser Tyr Glu 
65                  70                  75                  80  


Glu Ala Ile Asp Ala Leu Lys Lys Thr Leu Ile Glu Lys Gly Glu Leu 
                85                  90                  95      


Glu Pro Val Ala Ala Thr Arg Ile Asp Gln Ile Thr Ala Gln Ala Ala 
            100                 105                 110         


Ala Pro Asp Thr Lys Ala Pro Phe Asp Pro Val Glu Arg Ile Lys Ser 
        115                 120                 125             


Gly Phe Val Lys Phe Lys Thr Glu Lys Phe Val Thr Asn Pro Ala Leu 
    130                 135                 140                 


Tyr Asp Glu Leu Ala Lys Gly Gln Ser Pro Lys Phe Met Val Phe Ala 
145                 150                 155                 160 


Cys Ser Asp Ser Arg Val Cys Pro Ser His Val Leu Asp Phe Gln Pro 
                165                 170                 175     


Gly Glu Ala Phe Val Val Arg Asn Val Ala Asn Met Val Pro Pro Phe 
            180                 185                 190         


Asp Lys Thr Lys Tyr Ser Gly Val Gly Ala Ala Val Glu Tyr Ala Val 
        195                 200                 205             


Leu His Leu Lys Val Gln Glu Ile Phe Val Ile Gly His Ser Arg Cys 
    210                 215                 220                 


Gly Gly Ile Lys Gly Leu Met Thr Phe Pro Asp Glu Gly Pro His Ser 
225                 230                 235                 240 


Thr Asp Phe Ile Glu Asp Trp Val Lys Val Cys Leu Pro Ala Lys Ser 
                245                 250                 255     


Lys Val Val Ala Glu His Asn Gly Thr His Leu Asp Asp Gln Cys Val 
            260                 265                 270         


Leu Cys Glu Lys Glu Ala Val Asn Val Ser Leu Gly Asn Leu Leu Thr 
        275                 280                 285             


Tyr Pro Phe Val Arg Asp Gly Leu Arg Asn Lys Thr Leu Ala Leu Lys 
    290                 295                 300                 


Gly Gly His Tyr Asp Phe Val Asn Gly Thr Phe Glu Leu Trp Ala Leu 
305                 310                 315                 320 


Asp Phe Gly Leu Ser Ser Pro Thr Ser Val 
                325                 330 


<210>  46
<211>  221
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  46

Met Ser Ala Thr Glu Ser Ser Ser Ile Phe Thr Leu Ser His Asn Ser 
1               5                   10                  15      


Asn Leu Gln Asp Ile Leu Ala Ala Asn Ala Lys Trp Ala Ser Gln Met 
            20                  25                  30          


Asn Asn Ile Gln Pro Thr Leu Phe Pro Asp His Asn Ala Lys Gly Gln 
        35                  40                  45              


Ser Pro His Thr Leu Phe Ile Gly Cys Ser Asp Ser Arg Tyr Asn Glu 
    50                  55                  60                  


Asn Cys Leu Gly Val Leu Pro Gly Glu Val Phe Thr Trp Lys Asn Val 
65                  70                  75                  80  


Ala Asn Ile Cys His Ser Glu Asp Leu Thr Leu Lys Ala Thr Leu Glu 
                85                  90                  95      


Phe Ala Ile Ile Cys Leu Lys Val Asn Lys Val Ile Ile Cys Gly His 
            100                 105                 110         


Thr Asp Cys Gly Gly Ile Lys Thr Cys Leu Thr Asn Gln Arg Glu Ala 
        115                 120                 125             


Leu Pro Lys Val Asn Cys Ser His Leu Tyr Lys Tyr Leu Asp Asp Ile 
    130                 135                 140                 


Asp Thr Met Tyr His Glu Glu Ser Gln Asn Leu Ile His Leu Lys Thr 
145                 150                 155                 160 


Gln Arg Glu Lys Ser His Tyr Leu Ser His Cys Asn Val Lys Arg Gln 
                165                 170                 175     


Phe Asn Arg Ile Ile Glu Asn Pro Thr Val Gln Thr Ala Val Gln Asn 
            180                 185                 190         


Gly Glu Leu Gln Val Tyr Gly Leu Leu Tyr Asn Val Glu Asp Gly Leu 
        195                 200                 205             


Leu Gln Thr Val Ser Thr Tyr Thr Lys Val Thr Pro Lys 
    210                 215                 220     


<210>  47
<211>  281
<212>  PRT
<213>  Candida albicans

<400>  47

Met Gly Arg Glu Asn Ile Leu Lys Tyr Gln Leu Glu His Asp His Glu 
1               5                   10                  15      


Ser Asp Leu Val Thr Glu Lys Asp Gln Ser Leu Leu Leu Asp Asn Asn 
            20                  25                  30          


Asn Asn Leu Asn Gly Met Asn Asn Thr Ile Lys Thr His Pro Val Arg 
        35                  40                  45              


Val Ser Ser Gly Asn His Asn Asn Phe Pro Phe Thr Leu Ser Ser Glu 
    50                  55                  60                  


Ser Thr Leu Gln Asp Phe Leu Asn Asn Asn Lys Phe Phe Val Asp Ser 
65                  70                  75                  80  


Ile Lys His Asn His Gly Asn Gln Ile Phe Asp Leu Asn Gly Gln Gly 
                85                  90                  95      


Gln Ser Pro His Thr Leu Trp Ile Gly Cys Ser Asp Ser Arg Ala Gly 
            100                 105                 110         


Asp Gln Cys Leu Ala Thr Leu Pro Gly Glu Ile Phe Val His Arg Asn 
        115                 120                 125             


Ile Ala Asn Ile Val Asn Ala Asn Asp Ile Ser Ser Gln Gly Val Ile 
    130                 135                 140                 


Gln Phe Ala Ile Asp Val Leu Lys Val Lys Lys Ile Ile Val Cys Gly 
145                 150                 155                 160 


His Thr Asp Cys Gly Gly Ile Trp Ala Ser Leu Ser Lys Lys Lys Ile 
                165                 170                 175     


Gly Gly Val Leu Asp Leu Trp Leu Asn Pro Val Arg His Ile Arg Ala 
            180                 185                 190         


Ala Asn Leu Lys Leu Leu Glu Glu Tyr Asn Gln Asp Pro Lys Leu Lys 
        195                 200                 205             


Ala Lys Lys Leu Ala Glu Leu Asn Val Ile Ser Ser Val Thr Ala Leu 
    210                 215                 220                 


Lys Arg His Pro Ser Ala Ser Val Ala Leu Lys Lys Asn Glu Ile Glu 
225                 230                 235                 240 


Val Trp Gly Met Leu Tyr Asp Val Ala Thr Gly Tyr Leu Ser Gln Val 
                245                 250                 255     


Glu Ile Pro Gln Asp Glu Phe Glu Asp Leu Phe His Val His Asp Glu 
            260                 265                 270         


His Asp Glu Glu Glu Tyr Asn Pro His 
        275                 280     


<210>  48
<211>  192
<212>  PRT
<213>  Porphyromonas gingivalis

<400>  48

Met Ala Gln Arg Glu Asn Ser Asp Tyr Leu Thr Thr Lys Met Ala Leu 
1               5                   10                  15      


Ile Gln Ser Val Arg Gly Phe Thr Pro Ile Ile Gly Glu Asp Thr Phe 
            20                  25                  30          


Leu Ala Glu Asn Ala Thr Ile Val Gly Asp Val Val Met Gly Lys Gly 
        35                  40                  45              


Cys Ser Val Trp Phe Asn Ala Val Leu Arg Gly Asp Val Asn Ser Ile 
    50                  55                  60                  


Arg Ile Gly Asp Asn Val Asn Ile Gln Asp Gly Ser Ile Leu His Thr 
65                  70                  75                  80  


Leu Tyr Gln Lys Ser Thr Ile Glu Ile Gly Asp Asn Val Ser Val Gly 
                85                  90                  95      


His Asn Val Val Ile His Gly Ala Lys Ile Cys Asp Tyr Ala Leu Ile 
            100                 105                 110         


Gly Met Gly Ala Val Val Leu Asp His Val Val Val Gly Glu Gly Ala 
        115                 120                 125             


Ile Val Ala Ala Gly Ser Val Val Leu Thr Gly Thr Gln Ile Glu Pro 
    130                 135                 140                 


Asn Ser Ile Tyr Ala Gly Ala Pro Ala Arg Phe Ile Lys Lys Val Asp 
145                 150                 155                 160 


Pro Glu Gln Ser Arg Glu Met Asn Phe Arg Ile Ala His Asn Tyr Arg 
                165                 170                 175     


Met Tyr Ala Ser Trp Phe Lys Asp Glu Ser Ser Glu Ile Asp Asn Pro 
            180                 185                 190         


<210>  49
<211>  207
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  49

Met Pro Asn Thr Asn Pro Val Ala Ala Trp Lys Ala Leu Lys Glu Gly 
1               5                   10                  15      


Asn Glu Arg Phe Val Ala Gly Arg Pro Gln His Pro Ser Gln Ser Val 
            20                  25                  30          


Asp His Arg Ala Gly Leu Ala Ala Gly Gln Lys Pro Thr Ala Val Ile 
        35                  40                  45              


Phe Gly Cys Ala Asp Ser Arg Val Ala Ala Glu Ile Ile Phe Asp Gln 
    50                  55                  60                  


Gly Leu Gly Asp Met Phe Val Val Arg Thr Ala Gly His Val Ile Asp 
65                  70                  75                  80  


Ser Ala Val Leu Gly Ser Ile Glu Tyr Ala Val Thr Val Leu Asn Val 
                85                  90                  95      


Pro Leu Ile Val Val Leu Gly His Asp Ser Cys Gly Ala Val Asn Ala 
            100                 105                 110         


Ala Leu Ala Ala Ile Asn Asp Gly Thr Leu Pro Gly Gly Tyr Val Arg 
        115                 120                 125             


Asp Val Val Glu Arg Val Ala Pro Ser Val Leu Leu Gly Arg Arg Asp 
    130                 135                 140                 


Gly Leu Ser Arg Val Asp Glu Phe Glu Gln Arg His Val His Glu Thr 
145                 150                 155                 160 


Val Ala Ile Leu Met Ala Arg Ser Ser Ala Ile Ser Glu Arg Ile Ala 
                165                 170                 175     


Gly Gly Ser Leu Ala Ile Val Gly Val Thr Tyr Gln Leu Asp Asp Gly 
            180                 185                 190         


Arg Ala Val Leu Arg Asp His Ile Gly Asn Ile Gly Glu Glu Val 
        195                 200                 205         


<210>  50
<211>  219
<212>  PRT
<213>  Escherichia coli

<400>  50

Met Lys Glu Ile Ile Asp Gly Phe Leu Lys Phe Gln Arg Glu Ala Phe 
1               5                   10                  15      


Pro Lys Arg Glu Ala Leu Phe Lys Gln Leu Ala Thr Gln Gln Ser Pro 
            20                  25                  30          


Arg Thr Leu Phe Ile Ser Cys Ser Asp Ser Arg Leu Val Pro Glu Leu 
        35                  40                  45              


Val Thr Gln Arg Glu Pro Gly Asp Leu Phe Val Ile Arg Asn Ala Gly 
    50                  55                  60                  


Asn Ile Val Pro Ser Tyr Gly Pro Glu Pro Gly Gly Val Ser Ala Ser 
65                  70                  75                  80  


Val Glu Tyr Ala Val Ala Ala Leu Arg Val Ser Asp Ile Val Ile Cys 
                85                  90                  95      


Gly His Ser Asn Cys Gly Ala Met Thr Ala Ile Ala Ser Cys Gln Cys 
            100                 105                 110         


Met Asp His Met Pro Ala Val Ser His Trp Leu Arg Tyr Ala Asp Ser 
        115                 120                 125             


Ala Arg Val Val Asn Glu Ala Arg Pro His Ser Asp Leu Pro Ser Lys 
    130                 135                 140                 


Ala Ala Ala Met Val Arg Glu Asn Val Ile Ala Gln Leu Ala Asn Leu 
145                 150                 155                 160 


Gln Thr His Pro Ser Val Arg Leu Ala Leu Glu Glu Gly Arg Ile Ala 
                165                 170                 175     


Leu His Gly Trp Val Tyr Asp Ile Glu Ser Gly Ser Ile Ala Ala Phe 
            180                 185                 190         


Asp Gly Ala Thr Arg Gln Phe Val Pro Leu Ala Ala Asn Pro Arg Val 
        195                 200                 205             


Cys Ala Ile Pro Leu Arg Gln Pro Thr Ala Ala 
    210                 215                 


<210>  51
<211>  220
<212>  PRT
<213>  Escherichia coli

<400>  51

Met Lys Asp Ile Asp Thr Leu Ile Ser Asn Asn Ala Leu Trp Ser Lys 
1               5                   10                  15      


Met Leu Val Glu Glu Asp Pro Gly Phe Phe Glu Lys Leu Ala Gln Ala 
            20                  25                  30          


Gln Lys Pro Arg Phe Leu Trp Ile Gly Cys Ser Asp Ser Arg Val Pro 
        35                  40                  45              


Ala Glu Arg Leu Thr Gly Leu Glu Pro Gly Glu Leu Phe Val His Arg 
    50                  55                  60                  


Asn Val Ala Asn Leu Val Ile His Thr Asp Leu Asn Cys Leu Ser Val 
65                  70                  75                  80  


Val Gln Tyr Ala Val Asp Val Leu Glu Val Glu His Ile Ile Ile Cys 
                85                  90                  95      


Gly His Tyr Gly Cys Gly Gly Val Gln Ala Ala Val Glu Asn Pro Glu 
            100                 105                 110         


Leu Gly Leu Ile Asn Asn Trp Leu Leu His Ile Arg Asp Ile Trp Phe 
        115                 120                 125             


Lys His Ser Ser Leu Leu Gly Glu Met Pro Gln Glu Arg Arg Leu Asp 
    130                 135                 140                 


Thr Leu Cys Glu Leu Asn Val Met Glu Gln Val Tyr Asn Leu Gly His 
145                 150                 155                 160 


Ser Thr Ile Met Gln Ser Ala Trp Lys Arg Gly Gln Lys Val Thr Ile 
                165                 170                 175     


His Gly Trp Ala Tyr Gly Ile His Asp Gly Leu Leu Arg Asp Leu Asp 
            180                 185                 190         


Val Thr Ala Thr Asn Arg Glu Thr Leu Glu Gln Arg Tyr Arg His Gly 
        195                 200                 205             


Ile Ser Asn Leu Lys Leu Lys His Ala Asn His Lys 
    210                 215                 220 


<210>  52
<211>  450
<212>  PRT
<213>  Clostridium symbiosum

<400>  52

Met Ser Lys Tyr Val Asp Arg Val Ile Ala Glu Val Glu Lys Lys Tyr 
1               5                   10                  15      


Ala Asp Glu Pro Glu Phe Val Gln Thr Val Glu Glu Val Leu Ser Ser 
            20                  25                  30          


Leu Gly Pro Val Val Asp Ala His Pro Glu Tyr Glu Glu Val Ala Leu 
        35                  40                  45              


Leu Glu Arg Met Val Ile Pro Glu Arg Val Ile Glu Phe Arg Val Pro 
    50                  55                  60                  


Trp Glu Asp Asp Asn Gly Lys Val His Val Asn Thr Gly Tyr Arg Val 
65                  70                  75                  80  


Gln Phe Asn Gly Ala Ile Gly Pro Tyr Lys Gly Gly Leu Arg Phe Ala 
                85                  90                  95      


Pro Ser Val Asn Leu Ser Ile Met Lys Phe Leu Gly Phe Glu Gln Ala 
            100                 105                 110         


Phe Lys Asp Ser Leu Thr Thr Leu Pro Met Gly Gly Ala Lys Gly Gly 
        115                 120                 125             


Ser Asp Phe Asp Pro Asn Gly Lys Ser Asp Arg Glu Val Met Arg Phe 
    130                 135                 140                 


Cys Gln Ala Phe Met Thr Glu Leu Tyr Arg His Ile Gly Pro Asp Ile 
145                 150                 155                 160 


Asp Val Pro Ala Gly Asp Leu Gly Val Gly Ala Arg Glu Ile Gly Tyr 
                165                 170                 175     


Met Tyr Gly Gln Tyr Arg Lys Ile Val Gly Gly Phe Tyr Asn Gly Val 
            180                 185                 190         


Leu Thr Gly Lys Ala Arg Ser Phe Gly Gly Ser Leu Val Arg Pro Glu 
        195                 200                 205             


Ala Thr Gly Tyr Gly Ser Val Tyr Tyr Val Glu Ala Val Met Lys His 
    210                 215                 220                 


Glu Asn Asp Thr Leu Val Gly Lys Thr Val Ala Leu Ala Gly Phe Gly 
225                 230                 235                 240 


Asn Val Ala Trp Gly Ala Ala Lys Lys Leu Ala Glu Leu Gly Ala Lys 
                245                 250                 255     


Ala Val Thr Leu Ser Gly Pro Asp Gly Tyr Ile Tyr Asp Pro Glu Gly 
            260                 265                 270         


Ile Thr Thr Glu Glu Lys Ile Asn Tyr Met Leu Glu Met Arg Ala Ser 
        275                 280                 285             


Gly Arg Asn Lys Val Gln Asp Tyr Ala Asp Lys Phe Gly Val Gln Phe 
    290                 295                 300                 


Phe Pro Gly Glu Lys Pro Trp Gly Gln Lys Val Asp Ile Ile Met Pro 
305                 310                 315                 320 


Cys Ala Thr Gln Asn Asp Val Asp Leu Glu Gln Ala Lys Lys Ile Val 
                325                 330                 335     


Ala Asn Asn Ile Lys Tyr Tyr Ile Glu Val Ala Asn Met Pro Thr Thr 
            340                 345                 350         


Asn Glu Ala Leu Arg Phe Leu Met Gln Gln Pro Asn Met Val Val Ala 
        355                 360                 365             


Pro Ser Lys Ala Val Asn Ala Gly Gly Val Leu Val Ser Gly Phe Glu 
    370                 375                 380                 


Met Ser Gln Asn Ser Glu Arg Leu Ser Trp Thr Ala Glu Glu Val Asp 
385                 390                 395                 400 


Ser Lys Leu His Gln Val Met Thr Asp Ile His Asp Gly Ser Ala Ala 
                405                 410                 415     


Ala Ala Glu Arg Tyr Gly Leu Gly Tyr Asn Leu Val Ala Gly Ala Asn 
            420                 425                 430         


Ile Val Gly Phe Gln Lys Ile Ala Asp Ala Met Met Ala Gln Gly Ile 
        435                 440                 445             


Ala Trp 
    450 


<210>  53
<211>  447
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  53

Met Thr Val Asp Glu Gln Val Ser Asn Tyr Tyr Asp Met Leu Leu Lys 
1               5                   10                  15      


Arg Asn Ala Gly Glu Pro Glu Phe His Gln Ala Val Ala Glu Val Leu 
            20                  25                  30          


Glu Ser Leu Lys Ile Val Leu Glu Lys Asp Pro His Tyr Ala Asp Tyr 
        35                  40                  45              


Gly Leu Ile Gln Arg Leu Cys Glu Pro Glu Arg Gln Leu Ile Phe Arg 
    50                  55                  60                  


Val Pro Trp Val Asp Asp Gln Gly Gln Val His Val Asn Arg Gly Phe 
65                  70                  75                  80  


Arg Val Gln Phe Asn Ser Ala Leu Gly Pro Tyr Lys Gly Gly Leu Arg 
                85                  90                  95      


Phe His Pro Ser Val Asn Leu Gly Ile Val Lys Phe Leu Gly Phe Glu 
            100                 105                 110         


Gln Ile Phe Lys Asn Ser Leu Thr Gly Leu Pro Ile Gly Gly Gly Lys 
        115                 120                 125             


Gly Gly Ser Asp Phe Asp Pro Lys Gly Lys Ser Asp Leu Glu Ile Met 
    130                 135                 140                 


Arg Phe Cys Gln Ser Phe Met Thr Glu Leu His Arg His Ile Gly Glu 
145                 150                 155                 160 


Tyr Arg Asp Val Pro Ala Gly Asp Ile Gly Val Gly Gly Arg Glu Ile 
                165                 170                 175     


Gly Tyr Leu Phe Gly His Tyr Arg Arg Met Ala Asn Gln His Glu Ser 
            180                 185                 190         


Gly Val Leu Thr Gly Lys Gly Leu Thr Trp Gly Gly Ser Leu Val Arg 
        195                 200                 205             


Thr Glu Ala Thr Gly Tyr Gly Cys Val Tyr Phe Val Ser Glu Met Ile 
    210                 215                 220                 


Lys Ala Lys Gly Glu Ser Ile Ser Gly Gln Lys Ile Ile Val Ser Gly 
225                 230                 235                 240 


Ser Gly Asn Val Ala Thr Tyr Ala Ile Glu Lys Ala Gln Glu Leu Gly 
                245                 250                 255     


Ala Thr Val Ile Gly Phe Ser Asp Ser Ser Gly Trp Val His Thr Pro 
            260                 265                 270         


Asn Gly Val Asp Val Ala Lys Leu Arg Glu Ile Lys Glu Val Arg Arg 
        275                 280                 285             


Ala Arg Val Ser Val Tyr Ala Asp Glu Val Glu Gly Ala Thr Tyr His 
    290                 295                 300                 


Thr Asp Gly Ser Ile Trp Asp Leu Lys Cys Asp Ile Ala Leu Pro Cys 
305                 310                 315                 320 


Ala Thr Gln Asn Glu Leu Asn Gly Glu Asn Ala Lys Thr Leu Ala Asp 
                325                 330                 335     


Asn Gly Cys Arg Phe Val Ala Glu Gly Ala Asn Met Pro Ser Thr Pro 
            340                 345                 350         


Glu Ala Val Glu Val Phe Arg Glu Arg Asp Ile Arg Phe Gly Pro Gly 
        355                 360                 365             


Lys Ala Ala Asn Ala Gly Gly Val Ala Thr Ser Ala Leu Glu Met Gln 
    370                 375                 380                 


Gln Asn Ala Ser Arg Asp Ser Trp Ser Phe Glu Tyr Thr Asp Glu Arg 
385                 390                 395                 400 


Leu Gln Val Ile Met Lys Asn Ile Phe Lys Thr Cys Ala Glu Thr Ala 
                405                 410                 415     


Ala Glu Tyr Gly His Glu Asn Asp Tyr Val Val Gly Ala Asn Ile Ala 
            420                 425                 430         


Gly Phe Lys Lys Val Ala Asp Ala Met Leu Ala Gln Gly Val Ile 
        435                 440                 445         


<210>  54
<211>  421
<212>  PRT
<213>  Peptoniphilus asaccharolyticus

<400>  54

Met Thr Asp Thr Leu Asn Pro Leu Val Ala Ala Gln Glu Lys Val Arg 
1               5                   10                  15      


Ile Ala Cys Glu Lys Leu Gly Cys Asp Pro Ala Val Tyr Glu Leu Leu 
            20                  25                  30          


Lys Glu Pro Gln Arg Val Ile Glu Ile Ser Ile Pro Val Lys Met Asp 
        35                  40                  45              


Asp Gly Thr Val Lys Val Phe Lys Gly Trp Arg Ser Ala His Ser Ser 
    50                  55                  60                  


Ala Val Gly Pro Ser Lys Gly Gly Val Arg Phe His Pro Asn Val Asn 
65                  70                  75                  80  


Met Asp Glu Val Lys Ala Leu Ser Leu Trp Met Thr Phe Lys Gly Gly 
                85                  90                  95      


Ala Leu Gly Leu Pro Tyr Gly Gly Gly Lys Gly Gly Ile Cys Val Asp 
            100                 105                 110         


Pro Ala Glu Leu Ser Glu Arg Glu Leu Glu Gln Leu Ser Arg Gly Trp 
        115                 120                 125             


Val Arg Gly Leu Tyr Lys Tyr Leu Gly Asp Arg Ile Asp Ile Pro Ala 
    130                 135                 140                 


Pro Asp Val Asn Thr Asn Gly Gln Ile Met Ser Trp Phe Val Asp Glu 
145                 150                 155                 160 


Tyr Val Lys Leu Asn Gly Glu Arg Met Asp Ile Gly Thr Phe Thr Gly 
                165                 170                 175     


Lys Pro Val Ala Phe Gly Gly Ser Glu Gly Arg Asn Glu Ala Thr Gly 
            180                 185                 190         


Phe Gly Val Ala Val Val Val Arg Glu Ser Ala Lys Arg Phe Gly Ile 
        195                 200                 205             


Lys Met Glu Asp Ala Lys Ile Ala Val Gln Gly Phe Gly Asn Val Gly 
    210                 215                 220                 


Thr Phe Thr Val Lys Asn Ile Glu Arg Gln Gly Gly Lys Val Cys Ala 
225                 230                 235                 240 


Ile Ala Glu Trp Asp Arg Asn Glu Gly Asn Tyr Ala Leu Tyr Asn Glu 
                245                 250                 255     


Asn Gly Ile Asp Phe Lys Glu Leu Leu Ala Tyr Lys Glu Ala Asn Lys 
            260                 265                 270         


Thr Leu Ile Gly Phe Pro Gly Ala Glu Arg Ile Thr Asp Glu Glu Phe 
        275                 280                 285             


Trp Thr Lys Glu Tyr Asp Ile Ile Val Pro Ala Ala Leu Glu Asn Val 
    290                 295                 300                 


Ile Thr Gly Glu Arg Ala Lys Thr Ile Asn Ala Lys Leu Val Cys Glu 
305                 310                 315                 320 


Ala Ala Asn Gly Pro Thr Thr Pro Glu Gly Asp Lys Val Leu Thr Glu 
                325                 330                 335     


Arg Gly Ile Asn Leu Thr Pro Asp Ile Leu Thr Asn Ser Gly Gly Val 
            340                 345                 350         


Leu Val Ser Tyr Tyr Glu Trp Val Gln Asn Gln Tyr Gly Tyr Tyr Trp 
        355                 360                 365             


Thr Glu Ala Glu Val Glu Glu Lys Gln Glu Ala Asp Met Met Lys Ala 
    370                 375                 380                 


Ile Lys Gly Val Phe Ala Val Ala Asp Glu Tyr Asn Val Thr Leu Arg 
385                 390                 395                 400 


Glu Ala Val Tyr Met Tyr Ala Ile Lys Ser Ile Asp Val Ala Met Lys 
                405                 410                 415     


Leu Arg Gly Trp Tyr 
            420     


