                         SEQUENCE LISTING

<110>  Cornell Research Foundation
 
<120>  SUBSTITUTED ALKYLPHENOLS AS HCN1 ANTAGONISTS

<130>  C1134.70010WO00

<140>  PCT/US2019/039493
<141>  2019-06-27

<150>  US 62/690,778
<151>  2018-06-27

<150>  US 62/803,109
<151>  2019-02-08

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  1

Met Glu Gly Pro Arg Arg Gln Tyr Gly Phe Met Gln Arg Gln Phe Thr 
1               5                   10                  15      


Ser Met Leu Gln Pro Gly Val Asn Lys Phe Ser Leu Arg Met Phe Gly 
            20                  25                  30          


Ser Gln Lys Ala Val Glu Lys Glu Gln Glu Arg Val Lys Thr Ala Gly 
        35                  40                  45              


Phe Trp Ile Ile His Pro Tyr Ser Asp Phe Arg Phe Tyr Trp Asp Leu 
    50                  55                  60                  


Ile Met Leu Ile Met Met Val Gly Asn Leu Val Ile Ile Pro Val Gly 
65                  70                  75                  80  


Ile Thr Phe Phe Thr Glu Gln Thr Thr Thr Pro Trp Ile Ile Phe Asn 
                85                  90                  95      


Val Ala Ser Asp Thr Val Phe Leu Leu Asp Leu Ile Met Asn Phe Arg 
            100                 105                 110         


Thr Gly Thr Val Asn Glu Asp Ser Ser Glu Ile Ile Leu Asp Pro Lys 
        115                 120                 125             


Val Ile Lys Met Asn Tyr Leu Lys Ser Trp Phe Val Val Asp Phe Ile 
    130                 135                 140                 


Ser Ser Ile Pro Val Asp Tyr Ile Phe Leu Ile Val Glu Lys Gly Met 
145                 150                 155                 160 


Asp Ser Glu Val Tyr Lys Thr Ala Arg Ala Leu Arg Ile Val Arg Phe 
                165                 170                 175     


Thr Lys Ile Leu Ser Leu Leu Arg Leu Leu Arg Leu Ser Arg Leu Ile 
            180                 185                 190         


Arg Tyr Ile His Gln Trp Glu Glu Ile Phe His Met Thr Tyr Asp Leu 
        195                 200                 205             


Ala Ser Ala Val Val Arg Ile Phe Asn Leu Ile Gly Met Met Leu Leu 
    210                 215                 220                 


Leu Cys His Trp Asp Gly Cys Leu Gln Phe Leu Val Pro Leu Leu Gln 
225                 230                 235                 240 


Asp Phe Pro Pro Asp Cys Trp Val Ser Leu Asn Glu Met Val Asn Asp 
                245                 250                 255     


Ser Trp Gly Lys Gln Tyr Ser Tyr Ala Leu Phe Lys Ala Met Ser His 
            260                 265                 270         


Met Leu Cys Ile Gly Tyr Gly Ala Gln Ala Pro Val Ser Met Ser Asp 
        275                 280                 285             


Leu Trp Ile Thr Met Leu Ser Met Ile Val Gly Ala Thr Cys Tyr Ala 
    290                 295                 300                 


Met Phe Val Gly His Ala Thr Ala Leu Ile Gln Ser Leu Asp 
305                 310                 315             


<210>  2
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  2

Met Glu Pro Arg Gly Ser Gln Ala Ser Phe Leu Gln Arg Gln Phe Gly 
1               5                   10                  15      


Ala Leu Leu Gln Pro Gly Val Asn Lys Phe Ser Leu Arg Met Phe Gly 
            20                  25                  30          


Ser Gln Lys Ala Val Glu Arg Glu Gln Glu Arg Val Lys Ser Ala Gly 
        35                  40                  45              


Ala Trp Ile Ile His Pro Tyr Ser Asp Phe Arg Phe Tyr Trp Asp Phe 
    50                  55                  60                  


Thr Met Leu Leu Phe Met Val Gly Asn Leu Ile Ile Ile Pro Val Gly 
65                  70                  75                  80  


Ile Thr Phe Phe Lys Asp Glu Thr Thr Ala Pro Trp Ile Val Phe Asn 
                85                  90                  95      


Val Val Ser Asp Thr Phe Phe Leu Met Asp Leu Val Leu Asn Phe Arg 
            100                 105                 110         


Thr Gly Ile Val Ile Glu Asp Asn Thr Glu Ile Ile Leu Asp Pro Glu 
        115                 120                 125             


Lys Ile Lys Lys Lys Tyr Leu Arg Thr Trp Phe Val Val Asp Phe Val 
    130                 135                 140                 


Ser Ser Ile Pro Val Asp Tyr Ile Phe Leu Ile Val Glu Lys Gly Ile 
145                 150                 155                 160 


Asp Ser Glu Val Tyr Lys Thr Ala Arg Ala Leu Arg Ile Val Arg Phe 
                165                 170                 175     


Thr Lys Ile Leu Ser Leu Leu Arg Leu Leu Arg Leu Ser Arg Leu Ile 
            180                 185                 190         


Arg Tyr Ile His Gln Trp Glu Glu Ile Phe His Met Thr Tyr Asp Leu 
        195                 200                 205             


Ala Ser Ala Val Met Arg Ile Cys Asn Leu Ile Ser Met Met Leu Leu 
    210                 215                 220                 


Leu Cys His Trp Asp Gly Cys Leu Gln Phe Leu Val Pro Met Leu Gln 
225                 230                 235                 240 


Asp Phe Pro Ser Asp Cys Trp Val Ser Ile Asn Asn Met Val Asn His 
                245                 250                 255     


Ser Trp Ser Glu Leu Tyr Ser Phe Ala Leu Phe Lys Ala Met Ser His 
            260                 265                 270         


Met Leu Cys Ile Gly Tyr Gly Arg Gln Ala Pro Glu Ser Met Thr Asp 
        275                 280                 285             


Ile Trp Leu Thr Met Leu Ser Met Ile Val Gly Ala Thr Cys Tyr Ala 
    290                 295                 300                 


Met Phe Ile Gly His Ala Thr Ala Leu Ile Gln Ser Leu Asp 
305                 310                 315             


<210>  3
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  3

Met Pro Ile Pro Lys Ser Gly Pro Glu Pro Lys Arg Arg His Leu Gly 
1               5                   10                  15      


Thr Leu Leu Gln Pro Thr Val Asn Lys Phe Ser Leu Arg Val Phe Gly 
            20                  25                  30          


Ser His Lys Ala Val Glu Ile Glu Gln Glu Arg Val Lys Ser Ala Gly 
        35                  40                  45              


Ala Trp Ile Ile His Pro Tyr Ser Asp Phe Arg Phe Tyr Trp Asp Leu 
    50                  55                  60                  


Ile Met Leu Leu Leu Met Val Gly Asn Leu Ile Val Leu Pro Val Gly 
65                  70                  75                  80  


Ile Thr Phe Phe Lys Glu Glu Asn Ser Pro Pro Trp Ile Val Phe Asn 
                85                  90                  95      


Val Leu Ser Asp Thr Phe Phe Leu Leu Asp Leu Val Leu Asn Phe Arg 
            100                 105                 110         


Thr Gly Ile Val Val Glu Glu Gly Ala Glu Ile Leu Leu Ala Pro Arg 
        115                 120                 125             


Ala Ile Arg Thr Arg Tyr Arg Leu Thr Trp Phe Leu Val Asp Leu Ile 
    130                 135                 140                 


Ser Ser Ile Pro Val Asp Tyr Ile Phe Leu Val Val Glu Leu Glu Pro 
145                 150                 155                 160 


Arg Leu Asp Ala Glu Val Tyr Lys Thr Ala Arg Ala Leu Arg Ile Val 
                165                 170                 175     


Arg Phe Thr Lys Ile Leu Ser Leu Leu Arg Leu Leu Arg Leu Ser Arg 
            180                 185                 190         


Leu Ile Arg Tyr Ile His Gln Trp Glu Glu Ile Phe His Met Thr Tyr 
        195                 200                 205             


Asp Leu Ala Ser Ala Val Val Arg Ile Phe Asn Leu Ile Gly Met Met 
    210                 215                 220                 


Leu Leu Leu Cys His Trp Asp Gly Cys Leu Gln Phe Leu Val Pro Met 
225                 230                 235                 240 


Leu Gln Asp Phe Pro Pro Asp Cys Trp Val Ser Ile Asn His Met Val 
                245                 250                 255     


Asn His Ser Trp Gly Arg Gln Tyr Ser His Ala Leu Phe Lys Ala Met 
            260                 265                 270         


Ser His Met Leu Cys Ile Gly Tyr Gly Gln Gln Ala Pro Val Gly Met 
        275                 280                 285             


Pro Asp Val Trp Leu Thr Met Leu Ser Met Ile Val Gly Ala Thr Cys 
    290                 295                 300                 


Tyr Ala Met Phe Ile Gly His Ala Thr Ala Leu Ile Gln Ser Leu Asp 
305                 310                 315                 320 


<210>  4
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  4

Met Glu Val Arg Leu Gly Gln Ser Gly Phe Met Gln Arg Gln Phe Gly 
1               5                   10                  15      


Ala Met Leu Gln Pro Gly Val Asn Lys Phe Ser Leu Arg Met Phe Gly 
            20                  25                  30          


Ser Gln Lys Ala Val Glu Arg Glu Gln Glu Arg Val Lys Ser Ala Gly 
        35                  40                  45              


Phe Trp Ile Ile His Pro Tyr Ser Asp Phe Arg Phe Tyr Trp Asp Leu 
    50                  55                  60                  


Thr Met Leu Leu Leu Met Val Gly Asn Leu Ile Ile Ile Pro Val Gly 
65                  70                  75                  80  


Ile Thr Phe Phe Lys Asp Glu Asn Thr Thr Pro Trp Ile Val Phe Asn 
                85                  90                  95      


Val Val Ser Asp Thr Phe Phe Leu Ile Asp Leu Val Leu Asn Phe Arg 
            100                 105                 110         


Thr Gly Ile Val Val Glu Asp Asn Thr Glu Ile Ile Leu Asp Pro Gln 
        115                 120                 125             


Arg Ile Lys Met Lys Tyr Leu Lys Ser Trp Phe Val Val Asp Phe Ile 
    130                 135                 140                 


Ser Ser Ile Pro Val Glu Tyr Ile Phe Leu Ile Val Glu Thr Arg Ile 
145                 150                 155                 160 


Asp Ser Glu Val Tyr Lys Thr Ala Arg Ala Val Arg Ile Val Arg Phe 
                165                 170                 175     


Thr Lys Ile Leu Ser Leu Leu Arg Leu Leu Arg Leu Ser Arg Leu Ile 
            180                 185                 190         


Arg Tyr Ile His Gln Trp Glu Glu Ile Phe His Met Thr Tyr Asp Leu 
        195                 200                 205             


Ala Ser Ala Val Val Arg Ile Val Asn Leu Ile Gly Met Met Leu Leu 
    210                 215                 220                 


Leu Cys His Trp Asp Gly Cys Leu Gln Phe Leu Val Pro Met Leu Gln 
225                 230                 235                 240 


Asp Phe Pro His Asp Cys Trp Val Ser Ile Asn Gly Met Val Asn Asn 
                245                 250                 255     


Ser Trp Gly Lys Gln Tyr Ser Tyr Ala Leu Phe Lys Ala Met Ser His 
            260                 265                 270         


Met Leu Cys Ile Gly Tyr Gly Arg Gln Ala Pro Val Gly Met Ser Asp 
        275                 280                 285             


Val Trp Leu Thr Met Leu Ser Met Ile Val Gly Ala Thr Cys Tyr Ala 
    290                 295                 300                 


Met Phe Ile Gly His Ala Thr Ala Leu Ile Gln Ser Leu Asp 
305                 310                 315             


