                               SEQUENCE LISTING

<110> EDITAS MEDICINE, INC.

<120> SYNTHETIC GUIDE MOLECULES, COMPOSITIONS AND METHODS RELATING
      THERETO

<130> 2011271-0088

<140> PCT/US2019/039848
<141> 2019-06-28

<150> 62/692,492
<151> 2018-06-29

<160> 123   

<170> PatentIn version 3.5

<210> 1
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1
guuuuagagc uag                                                          13


<210> 2
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
auagcaaguu aaaau                                                        15


<210> 3
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
guuuuagagc u                                                            11


<210> 4
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 4
agcaaguuaa aau                                                          13


<210> 5
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
guuuuagagc uag                                                          13


<210> 6
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
cuagcaaguu aaaau                                                        15


<210> 7
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
guuuuagagc uaug                                                         14


<210> 8
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
cauagcaagu uaaaau                                                       16


<210> 9
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
guauuagagc uaugcuguuu u                                                 21


<210> 10
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
aaaacagcau agcaaguuaa uau                                               23


<210> 11
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
guauuagagc uaugcu                                                       16


<210> 12
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
agcauagcaa guuaauau                                                     18


<210> 13
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
guuuuagagc uaugcuguuu u                                                 21


<210> 14
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
aaaacagcau agcaaguuaa aau                                               23


<210> 15
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
guuuuagagc uaugcu                                                       16


<210> 16
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 16
agcauagcaa guuaaaaa                                                     18


<210> 17
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 17
guuuuagagc uaaag                                                        15


<210> 18
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 18
auuuagcaag uuaaaau                                                      17


<210> 19
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
guuuuagagc uaa                                                          13


<210> 20
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
uuagcaaguu aaaau                                                        15


<210> 21
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 21
guuuuagagc uaaaggg                                                      17


<210> 22
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 22
accuuuagca aguuaaaau                                                    19


<210> 23
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 23
guuuuagagc uag                                                          13


<210> 24
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 24
guuuuaguac ucu                                                          13


<210> 25
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 25
agaaucuacu aaaac                                                        15


<210> 26
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 26
guuuuaguac ucugua                                                       16


<210> 27
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 27
uacagaaucu acuaaaac                                                     18


<210> 28
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 28
guuuuaguac ucuguaauuu uagg                                              24


<210> 29
<211> 26
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 29
ccuaaaauua cagaaucuac uaaaac                                            26


<210> 30
<211> 29
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 30
guuuuaguac ucuguaauuu uagguauga                                         29


<210> 31
<211> 31
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 31
ucauaccuaa aauuacagaa ucuacuaaaa c                                      31


<210> 32
<211> 100
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other

<400> 32
nnnnnnnnnn nnnnnnnnnn guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210> 33
<211> 34
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other

<400> 33
nnnnnnnnnn nnnnnnnnnn guuuuagagc uaga                                   34


<210> 34
<211> 66
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 34
aauagcaagu uaaaauaagg cuaguccguu aucaacuuga aaaaguggca ccgagucggu       60

gcuuuu                                                                  66


<210> 35
<211> 34
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other

<400> 35
nnnnnnnnnn nnnnnnnnnn guuuuagagc uaga                                   34


<210> 36
<211> 34
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 36
guaacggcag acuucuccuc guuuuagagc uaga                                   34


<210> 37
<211> 32
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 37
guaacggcag acuucuccuc guuuuagagc ua                                     32


<210> 38
<211> 34
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 38
guaacggcag acuucuccuc guuuuagagc uagg                                   34


<210> 39
<211> 35
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 39
guaacggcag acuucuccuc guuuuagagc uaugc                                  35


<210> 40
<211> 42
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 40
guaacggcag acuucuccuc guauuagagc uaugcuguuu ug                          42


<210> 41
<211> 37
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 41
guaacggcag acuucuccuc guauuagagc uaugcug                                37


<210> 42
<211> 42
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 42
guaacggcag acuucuccuc guuuuagagc uaugcuguuu ug                          42


<210> 43
<211> 37
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 43
guaacggcag acuucuccuc guuuuagagc uaugcug                                37


<210> 44
<211> 36
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 44
guaacggcag acuucuccuc guuuuagagc uaaaga                                 36


<210> 45
<211> 34
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 45
guaacggcag acuucuccuc guuuuagagc uaaa                                   34


<210> 46
<211> 38
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 46
guaacggcag acuucuccuc guuuuagagc uaaaggga                               38


<210> 47
<211> 35
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 47
guaacggcag acuucuccuc guuuuagagc uagda                                  35


<210> 48
<211> 35
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 48
cuaacaguug cuuuuaucac guuuuagagc uaugc                                  35


<210> 49
<211> 37
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 49
cuaacaguug cuuuuaucac guuuuagagc uaugcug                                37


<210> 50
<211> 42
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 50
cuaacaguug cuuuuaucac guuuuagagc uaugcuguuu ug                          42


<210> 51
<211> 42
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 51
cuaacaguug cuuuuaucac guauuagagc uaugcuguuu ug                          42


<210> 52
<211> 34
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 52
cuaacaguug cuuuuaucac guuuuagagc uaga                                   34


<210> 53
<211> 34
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 53
guaacggcag acuucuccuc guuuuaguac ucug                                   34


<210> 54
<211> 37
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 54
guaacggcag acuucuccuc guuuuaguac ucuguaa                                37


<210> 55
<211> 45
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 55
guaacggcag acuucuccuc guuuuaguac ucuguaauuu uaggu                       45


<210> 56
<211> 50
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 56
guaacggcag acuucuccuc guuuuaguac ucuguaauuu uagguaugag                  50


<210> 57
<211> 66
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 57
aauagcaagu uaaaauaagg cuaguccguu aucaacuuga aaaaguggca ccgagucggu       60

gcuuuu                                                                  66


<210> 58
<211> 66
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 58
aauagcaagu uaaaauaagg cuaguccguu aucaacuuga aaaaguggca ccgagucggu       60

gcuuuu                                                                  66


<210> 59
<211> 64
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 59
uagcaaguua aaauaaggcu aguccguuau caacuugaaa aaguggcacc gagucggugc       60

uuuu                                                                    64


<210> 60
<211> 66
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 60
ccuagcaagu uaaaauaagg cuaguccguu aucaacuuga aaaaguggca ccgagucggu       60

gcuuuu                                                                  66


<210> 61
<211> 67
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 61
gcauagcaag uuaaaauaag gcuaguccgu uaucaacuug aaaaaguggc accgagucgg       60

ugcuuuu                                                                 67


<210> 62
<211> 74
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 62
caaaacagca uagcaaguua auauaaggcu aguccguuau caacuugaaa aaguggcacc       60

gagucggugc uuuu                                                         74


<210> 63
<211> 69
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 63
cagcauagca aguuaauaua aggcuagucc guuaucaacu ugaaaaagug gcaccgaguc       60

ggugcuuuu                                                               69


<210> 64
<211> 74
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 64
caaaacagca uagcaaguua aaauaaggcu aguccguuau caacuugaaa aaguggcacc       60

gagucggugc uuuu                                                         74


<210> 65
<211> 69
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 65
cagcauagca aguuaaaaaa aggcuagucc guuaucaacu ugaaaaagug gcaccgaguc       60

ggugcuuuu                                                               69


<210> 66
<211> 68
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 66
aauuuagcaa guuaaaauaa ggcuaguccg uuaucaacuu gaaaaagugg caccgagucg       60

gugcuuuu                                                                68


<210> 67
<211> 66
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 67
uuuagcaagu uaaaauaagg cuaguccguu aucaacuuga aaaaguggca ccgagucggu       60

gcuuuu                                                                  66


<210> 68
<211> 70
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 68
aaccuuuagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu ggcaccgagu       60

cggugcuuuu                                                              70


<210> 69
<211> 66
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 69
aauagcaagu uaaaauaagg cuaguccguu aucaacuuga aaaaguggca ccgagucggu       60

gcuuuu                                                                  66


<210> 70
<211> 67
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 70
gcauagcaag uuaaaauaag gcuaguccgu uaucaacuug aaaaaguggc accgagucgg       60

ugcuuuu                                                                 67


<210> 71
<211> 69
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 71
cagcauagca aguuaaaaua aggcuagucc guuaucaacu ugaaaaagug gcaccgaguc       60

ggugcuuuu                                                               69


<210> 72
<211> 74
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 72
caaaacagca uagcaaguua aaauaaggcu aguccguuau caacuugaaa aaguggcacc       60

gagucggugc uuuu                                                         74


<210> 73
<211> 74
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 73
caaaacagca uagcaaguua auauaaggcu aguccguuau caacuugaaa aaguggcacc       60

gagucggugc uuuu                                                         74


<210> 74
<211> 66
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 74
aauagcaagu uaaaauaagg cuaguccguu aucaacuuga aaaaguggca ccgagucggu       60

gcuuuu                                                                  66


<210> 75
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 75
cagaaucuac uaaaacaagg caaaaugccg uguuuaucuc gucaacuugu uggcgagauu       60

uu                                                                      62


<210> 76
<211> 65
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 76
uuacagaauc uacuaaaaca aggcaaaaug ccguguuuau cucgucaacu uguuggcgag       60

auuuu                                                                   65


<210> 77
<211> 73
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 77
accuaaaauu acagaaucua cuaaaacaag gcaaaaugcc guguuuaucu cgucaacuug       60

uuggcgagau uuu                                                          73


<210> 78
<211> 78
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 78
cucauaccua aaauuacaga aucuacuaaa acaaggcaaa augccguguu uaucucguca       60

acuuguuggc gagauuuu                                                     78


<210> 79
<211> 54
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(15)
<223> a, c, u, g, unknown or other

<220>
<221> modified_base
<222> (27)..(48)
<223> a, c, u, g, unknown or other

<220>
<221> misc_feature
<222> (27)..(48)
<223> This region may encompass 2-22 nucleotides

<220>
<221> modified_base
<222> (49)..(54)
<223> a, c, u, g, unknown or other

<220>
<221> misc_feature
<222> (49)..(54)
<223> This region may encompass 0-6 nucleotides

<220>
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 79
nnnnnnnnnn nnnnnuuuua gagcuannnn nnnnnnnnnn nnnnnnnnnn nnnn             54


<210> 80
<211> 71
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> a, c, u, g, unknown or other

<220>
<221> misc_feature
<222> (1)..(6)
<223> This region may encompass 0-6 nucleotides

<220>
<221> modified_base
<222> (7)..(28)
<223> a, c, u, g, unknown or other

<220>
<221> misc_feature
<222> (7)..(28)
<223> This region may encompass 2-22 nucleotides

<220>
<221> modified_base
<222> (42)..(71)
<223> a, c, u, g, unknown or other

<220>
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 80
nnnnnnnnnn nnnnnnnnnn nnnnnnnnua gcaaguuaaa annnnnnnnn nnnnnnnnnn       60

nnnnnnnnnn n                                                            71


<210> 81
<211> 54
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(15)
<223> a, c, u, g, unknown or other

<220>
<221> modified_base
<222> (27)..(48)
<223> a, c, u, g, unknown or other

<220>
<221> misc_feature
<222> (27)..(48)
<223> This region may encompass 2-22 nucleotides

<220>
<221> modified_base
<222> (49)..(54)
<223> a, c, u, g, unknown or other

<220>
<221> misc_feature
<222> (49)..(54)
<223> This region may encompass 0-6 nucleotides

<220>
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 81
nnnnnnnnnn nnnnnuauua gagcuannnn nnnnnnnnnn nnnnnnnnnn nnnn             54


<210> 82
<211> 71
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> a, c, u, g, unknown or other

<220>
<221> misc_feature
<222> (1)..(6)
<223> This region may encompass 0-6 nucleotides

<220>
<221> modified_base
<222> (7)..(28)
<223> a, c, u, g, unknown or other

<220>
<221> misc_feature
<222> (7)..(28)
<223> This region may encompass 2-22 nucleotides

<220>
<221> modified_base
<222> (42)..(71)
<223> a, c, u, g, unknown or other

<220>
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 82
nnnnnnnnnn nnnnnnnnnn nnnnnnnnua gcaaguuaau annnnnnnnn nnnnnnnnnn       60

nnnnnnnnnn n                                                            71


<210> 83
<211> 57
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(15)
<223> a, c, u, g, unknown or other

<220>
<221> modified_base
<222> (30)..(51)
<223> a, c, u, g, unknown or other

<220>
<221> misc_feature
<222> (30)..(51)
<223> This region may encompass 2-22 nucleotides

<220>
<221> modified_base
<222> (52)..(57)
<223> a, c, u, g, unknown or other

<220>
<221> misc_feature
<222> (52)..(57)
<223> This region may encompass 0-6 nucleotides

<220>
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 83
nnnnnnnnnn nnnnnguuuu aguacucugn nnnnnnnnnn nnnnnnnnnn nnnnnnn          57


<210> 84
<211> 74
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> a, c, u, g, unknown or other

<220>
<221> misc_feature
<222> (1)..(6)
<223> This region may encompass 0-6 nucleotides

<220>
<221> modified_base
<222> (7)..(28)
<223> a, c, u, g, unknown or other

<220>
<221> misc_feature
<222> (7)..(28)
<223> This region may encompass 2-22 nucleotides

<220>
<221> modified_base
<222> (45)..(74)
<223> a, c, u, g, unknown or other 

<220>
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 84
nnnnnnnnnn nnnnnnnnnn nnnnnnnnca gaaucuacua aaacnnnnnn nnnnnnnnnn       60

nnnnnnnnnn nnnn                                                         74


<210> 85
<211> 57
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(15)
<223> a, c, u, g, unknown or other

<220>
<221> modified_base
<222> (30)..(51)
<223> a, c, u, g, unknown or other

<220>
<221> misc_feature
<222> (30)..(51)
<223> This region may encompass 2-22 nucleotides

<220>
<221> modified_base
<222> (52)..(57)
<223> a, c, u, g, unknown or other

<220>
<221> misc_feature
<222> (52)..(57)
<223> This region may encompass 0-6 nucleotides

<220>
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 85
nnnnnnnnnn nnnnnguauu aguacucugn nnnnnnnnnn nnnnnnnnnn nnnnnnn          57


<210> 86
<211> 74
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(6)
<223> a, c, u, g, unknown or other

<220>
<221> misc_feature
<222> (1)..(6)
<223> This region may encompass 0-6 nucleotides

<220>
<221> modified_base
<222> (7)..(28)
<223> a, c, u, g, unknown or other

<220>
<221> misc_feature
<222> (7)..(28)
<223> This region may encompass 2-22 nucleotides

<220>
<221> modified_base
<222> (45)..(74)
<223> a, c, u, g, unknown or other 

<220>
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 86
nnnnnnnnnn nnnnnnnnnn nnnnnnnnca gaaucuacua auacnnnnnn nnnnnnnnnn       60

nnnnnnnnnn nnnn                                                         74


<210> 87
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 87
uaauuuuagg                                                              10


<210> 88
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 88
uaauuuuagg u                                                            11


<210> 89
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 89
uaauuuuagg ua                                                           12


<210> 90
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 90
uaauuuuagg uau                                                          13


<210> 91
<211> 14
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 91
uaauuuuagg uaug                                                         14


<210> 92
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 92
uaauuuuagg uauga                                                        15


<210> 93
<211> 101
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (1)..(21)
<223> a, c, u, g, unknown or other

<400> 93
nnnnnnnnnn nnnnnnnnnn nguuuuagag cuagaaauag caaguuaaaa uaaggcuagu       60

ccguuaucaa cuugaaaaag uggcaccgag ucggugcuuu u                          101


<210> 94
<211> 104
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (1)..(21)
<223> a, c, u, g, unknown or other

<400> 94
nnnnnnnnnn nnnnnnnnnn nguuuuagua cucuggaaac agaaucuacu aaaacaaggc       60

aaaaugccgu guuuaucucg ucaacuuguu ggcgagauuu uuuu                       104


<210> 95
<211> 34
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other

<400> 95
nnnnnnnnnn nnnnnnnnnn guuuuagagc uaga                                   34


<210> 96
<211> 66
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 96
aauagcaagu uaaaauaagg cuaguccguu aucaacuuga aaaaguggca ccgagucggu       60

gcuuuu                                                                  66


<210> 97
<211> 32
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other

<400> 97
nnnnnnnnnn nnnnnnnnnn guuuuagagc ua                                     32


<210> 98
<211> 64
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 98
uagcaaguua aaauaaggcu aguccguuau caacuugaaa aaguggcacc gagucggugc       60

uuuu                                                                    64


<210> 99
<211> 34
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other

<400> 99
nnnnnnnnnn nnnnnnnnnn guuuuagagc uagg                                   34


<210> 100
<211> 66
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 100
ccuagcaagu uaaaauaagg cuaguccguu aucaacuuga aaaaguggca ccgagucggu       60

gcuuuu                                                                  66


<210> 101
<211> 35
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other

<400> 101
nnnnnnnnnn nnnnnnnnnn guuuuagagc uaugc                                  35


<210> 102
<211> 67
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 102
gcauagcaag uuaaaauaag gcuaguccgu uaucaacuug aaaaaguggc accgagucgg       60

ugcuuuu                                                                 67


<210> 103
<211> 42
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other

<400> 103
nnnnnnnnnn nnnnnnnnnn guauuagagc uaugcuguuu ug                          42


<210> 104
<211> 74
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 104
caaaacagca uagcaaguua auauaaggcu aguccguuau caacuugaaa aaguggcacc       60

gagucggugc uuuu                                                         74


<210> 105
<211> 37
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other

<400> 105
nnnnnnnnnn nnnnnnnnnn guauuagagc uaugcug                                37


<210> 106
<211> 69
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 106
cagcauagca aguuaauaua aggcuagucc guuaucaacu ugaaaaagug gcaccgaguc       60

ggugcuuuu                                                               69


<210> 107
<211> 42
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other

<400> 107
nnnnnnnnnn nnnnnnnnnn guuuuagagc uaugcuguuu ug                          42


<210> 108
<211> 74
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 108
caaaacagca uagcaaguua aaauaaggcu aguccguuau caacuugaaa aaguggcacc       60

gagucggugc uuuu                                                         74


<210> 109
<211> 37
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other

<400> 109
nnnnnnnnnn nnnnnnnnnn guuuuagagc uaugcug                                37


<210> 110
<211> 69
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 110
cagcauagca aguuaaaaaa aggcuagucc guuaucaacu ugaaaaagug gcaccgaguc       60

ggugcuuuu                                                               69


<210> 111
<211> 37
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other

<400> 111
nnnnnnnnnn nnnnnnnnnn guuuuagagc uaugcug                                37


<210> 112
<211> 69
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 112
cagcauagca aguuaaaaua aggcuagucc guuaucaacu ugaaaaagug gcaccgaguc       60

ggugcuuuu                                                               69


<210> 113
<211> 34
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other

<400> 113
nnnnnnnnnn nnnnnnnnnn guuuuaguac ucug                                   34


<210> 114
<211> 62
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 114
cagaaucuac uaaaacaagg caaaaugccg uguuuaucuc gucaacuugu uggcgagauu       60

uu                                                                      62


<210> 115
<211> 37
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other

<400> 115
nnnnnnnnnn nnnnnnnnnn guuuuaguac ucuguaa                                37


<210> 116
<211> 65
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 116
uuacagaauc uacuaaaaca aggcaaaaug ccguguuuau cucgucaacu uguuggcgag       60

auuuu                                                                   65


<210> 117
<211> 45
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other

<400> 117
nnnnnnnnnn nnnnnnnnnn guuuuaguac ucuguaauuu uaggu                       45


<210> 118
<211> 73
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 118
accuaaaauu acagaaucua cuaaaacaag gcaaaaugcc guguuuaucu cgucaacuug       60

uuggcgagau uuu                                                          73


<210> 119
<211> 50
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(20)
<223> a, c, u, g, unknown or other

<400> 119
nnnnnnnnnn nnnnnnnnnn guuuuaguac ucuguaauuu uagguaugag                  50


<210> 120
<211> 78
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 120
cucauaccua aaauuacaga aucuacuaaa acaaggcaaa augccguguu uaucucguca       60

acuuguuggc gagauuuu                                                     78


<210> 121
<211> 10
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(10)
<223> This sequence may encompass 1-10 nucleotides

<400> 121
aaaaaaaaaa                                                              10


<210> 122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(20)
<223> This sequence may encompass 10-20 nucleotides

<400> 122
aaaaaaaaaa aaaaaaaaaa                                                   20


<210> 123
<211> 200
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> misc_feature
<222> (1)..(200)
<223> This sequence may encompass 25-200 nucleotides

<400> 123
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      120

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      180

aaaaaaaaaa aaaaaaaaaa                                                  200


