                         SEQUENCE LISTING

<110>  The City of Hope
 
<120>  COMPOSITIONS AND METHODS FOR TREATING AUTOIMMUNE DISEASES

<130>  048440-670001WO

<150>  US 62/692,509
<151>  2018-06-29

<160>  69    

<170>  PatentIn version 3.5

<210>  1
<211>  466
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  1
ggtctctggg gagcttgctt gttctttttg cagaagctca gaataaacgc tcaactttgg       60

ccgccaccat ggacatgagg gtccccgctc agctcctggg gctcctgctg ctctggctcc      120

caggtgccaa atgtgacatc cagatgaccc agtcccctat tctgctgagc gcctccgtgg      180

gcgaccgcgt gaccatcact tgcaaagcct cccgggatat ccggtcctac ctcacctggt      240

accagcagag gactaacgga tcgcccagaa ccctgatcta ctacgcgact agcctggccg      300

atggcgtccc gtcccggttc tcggggtcgg gttcaggaca ggactatagc cttaccatct      360

catccctgga gtccgatgac atcgccgact actactgcct gcaacacggc gaatctccct      420

tcacgttcgg gtccggaacc aagctcgaga ttaagcgaag aagagc                     466


<210>  2
<211>  379
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  2
gctcttcttc agaggtgcag cttgtggaat cgggtggcgg actggtcaag cctgggggat       60

cgctgaaact gagctgtgca gccagcggtt tcaagttctc acgctacgcc atgtcctggg      120

tcagacaggc gccgggaaag cgcctggaat gggtggctac tatctcctcc ggcggatcct      180

acatctacta ccccgactcc gtgaagggcc ggttcaccat tagccgcgac aacgtgaaga      240

acactctgta cctccaaatg tcaagcctga ggtctgagga taccgccatc tactattgcg      300

cccggcggga ctacgacttg gattactttg actcctgggg ccaggggacc ctcgtgaccg      360

tgtcctcggc caagagacc                                                   379


<210>  3
<211>  1783
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  3
ggggagcttg cttgttcttt ttgcagaagc tcagaataaa cgctcaactt tggccgccac       60

catggacatg agggtccccg ctcagctcct ggggctcctg ctgctctggc tcccaggtgc      120

caaatgtgac atccagatga cccagtcccc tattctgctg agcgcctccg tgggcgaccg      180

cgtgaccatc acttgcaaag cctcccggga tatccggtcc tacctcacct ggtaccagca      240

gaggactaac ggatcgccca gaaccctgat ctactacgcg actagcctgg ccgatggcgt      300

cccgtcccgg ttctcggggt cgggttcagg acaggactat agccttacca tctcatccct      360

ggagtccgat gacatcgccg actactactg cctgcaacac ggcgaatctc ccttcacgtt      420

cgggtccgga accaagctcg agattaagcg aactgtggct gcaccatctg tcttcatctt      480

cccgccatct gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa      540

cttctatccc agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa      600

ctcccaggag agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac      660

cctgacgctg agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca      720

tcagggcctg agctcgcccg tcacaaagag cttcaacagg ggagagtgtt aatagctctt      780

aaaaaattcc gccccccccc taacgttact ggccgaagcc gcttggaata aggccggtgt      840

gcgtttgtct atatgttatt ttccaccata ttgccgtctt ttggcaatgt gagggcccgg      900

aaacctggcc ctgtcttctt gacgagcatt cctaggggtc tttcccctct cgccaaagga      960

atgcaaggtc tgttgaatgt cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa     1020

acaacgtctg tagcgaccct ttgcaggcag cggaaccccc cacctggcga caggtgcctc     1080

tgcggccaaa agccacgtgt ataagataca cctgcaaagg cggcacaacc ccagtgccac     1140

gttgtgagtt ggatagttgt ggaaagagtc aaatggctct cctcaagcgt attcaacaag     1200

gggctgaagg atgcccagaa ggtaccccat tgtatgggat ctgatctggg gcctcggtac     1260

acatgcttta catgtgttta gtcgaggtta aaaaacgtct aggccccccg aaccacgggg     1320

acgtggtttt cctttgaaaa acacgatgat aatatggcca caaccatggg ctggtccctg     1380

atcctgctgt tcctggtggc cgtggccacg cgtgtgctgt cagaggtgca gcttgtggaa     1440

tcgggtggcg gactggtcaa gcctggggga tcgctgaaac tgagctgtgc agccagcggt     1500

ttcaagttct cacgctacgc catgtcctgg gtcagacagg cgccgggaaa gcgcctggaa     1560

tgggtggcta ctatctcctc cggcggatcc tacatctact accccgactc cgtgaagggc     1620

cggttcacca ttagccgcga caacgtgaag aacactctgt acctccaaat gtcaagcctg     1680

aggtctgagg ataccgccat ctactattgc gcccggcggg actacgactt ggattacttt     1740

gactcctggg gccaggggac cctcgtgacc gtgtcctcgg cca                       1783


<210>  4
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  4

Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu His 
1               5                   10                  15      


Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys Asn 
            20                  25                  30          


Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu Lys 
        35                  40                  45              


Trp Trp Glu Leu Arg 
    50              


<210>  5
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  5

Asp Gly Tyr Cys Leu His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu 
1               5                   10                  15      


Asp Lys Tyr Ala Cys 
            20      


<210>  6
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  6

Asp Gly Tyr Cys Leu His Asp Gly Val Ser Met Tyr Ile Glu Ala Leu 
1               5                   10                  15      


Asp Lys Tyr Ala Cys 
            20      


<210>  7
<211>  668
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Trp Leu Phe Phe Gly Ile Thr Gly Leu Leu Thr Ala Ala Leu Ser 
1               5                   10                  15      


Gly His Pro Ser Pro Ala Pro Pro Asp Gln Leu Asn Thr Ser Ser Ala 
            20                  25                  30          


Glu Ser Glu Leu Trp Glu Pro Gly Glu Arg Leu Pro Val Arg Leu Thr 
        35                  40                  45              


Asn Gly Ser Ser Ser Cys Ser Gly Thr Val Glu Val Arg Leu Glu Ala 
    50                  55                  60                  


Ser Trp Glu Pro Ala Cys Gly Ala Leu Trp Asp Ser Arg Ala Ala Glu 
65                  70                  75                  80  


Ala Val Cys Arg Ala Leu Gly Cys Gly Gly Ala Glu Ala Ala Ser Gln 
                85                  90                  95      


Leu Ala Pro Pro Thr Pro Glu Leu Pro Pro Pro Pro Ala Ala Gly Asn 
            100                 105                 110         


Thr Ser Val Ala Ala Asn Ala Thr Leu Ala Gly Ala Pro Ala Leu Leu 
        115                 120                 125             


Cys Ser Gly Ala Glu Trp Arg Leu Cys Glu Val Val Glu His Ala Cys 
    130                 135                 140                 


Arg Ser Asp Gly Arg Arg Ala Arg Val Thr Cys Ala Glu Asn Arg Ala 
145                 150                 155                 160 


Leu Arg Leu Val Asp Gly Gly Gly Ala Cys Ala Gly Arg Val Glu Met 
                165                 170                 175     


Leu Glu His Gly Glu Trp Gly Ser Val Cys Asp Asp Thr Trp Asp Leu 
            180                 185                 190         


Glu Asp Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Val 
        195                 200                 205             


Gln Ala Leu Pro Gly Leu His Phe Thr Pro Gly Arg Gly Pro Ile His 
    210                 215                 220                 


Arg Asp Gln Val Asn Cys Ser Gly Ala Glu Ala Tyr Leu Trp Asp Cys 
225                 230                 235                 240 


Pro Gly Leu Pro Gly Gln His Tyr Cys Gly His Lys Glu Asp Ala Gly 
                245                 250                 255     


Ala Val Cys Ser Glu His Gln Ser Trp Arg Leu Thr Gly Gly Ala Asp 
            260                 265                 270         


Arg Cys Glu Gly Gln Val Glu Val His Phe Arg Gly Val Trp Asn Thr 
        275                 280                 285             


Val Cys Asp Ser Glu Trp Tyr Pro Ser Glu Ala Lys Val Leu Cys Gln 
    290                 295                 300                 


Ser Leu Gly Cys Gly Thr Ala Val Glu Arg Pro Lys Gly Leu Pro His 
305                 310                 315                 320 


Ser Leu Ser Gly Arg Met Tyr Tyr Ser Cys Asn Gly Glu Glu Leu Thr 
                325                 330                 335     


Leu Ser Asn Cys Ser Trp Arg Phe Asn Asn Ser Asn Leu Cys Ser Gln 
            340                 345                 350         


Ser Leu Ala Ala Arg Val Leu Cys Ser Ala Ser Arg Ser Leu His Asn 
        355                 360                 365             


Leu Ser Thr Pro Glu Val Pro Ala Ser Val Gln Thr Val Thr Ile Glu 
    370                 375                 380                 


Ser Ser Val Thr Val Lys Ile Glu Asn Lys Glu Ser Arg Glu Leu Met 
385                 390                 395                 400 


Leu Leu Ile Pro Ser Ile Val Leu Gly Ile Leu Leu Leu Gly Ser Leu 
                405                 410                 415     


Ile Phe Ile Ala Phe Ile Leu Leu Arg Ile Lys Gly Lys Tyr Ala Leu 
            420                 425                 430         


Pro Val Met Val Asn His Gln His Leu Pro Thr Thr Ile Pro Ala Gly 
        435                 440                 445             


Ser Asn Ser Tyr Gln Pro Val Pro Ile Thr Ile Pro Lys Glu Val Phe 
    450                 455                 460                 


Met Leu Pro Ile Gln Val Gln Ala Pro Pro Pro Glu Asp Ser Asp Ser 
465                 470                 475                 480 


Gly Ser Asp Ser Asp Tyr Glu His Tyr Asp Phe Ser Ala Gln Pro Pro 
                485                 490                 495     


Val Ala Leu Thr Thr Phe Tyr Asn Ser Gln Arg His Arg Val Thr Asp 
            500                 505                 510         


Glu Glu Val Gln Gln Ser Arg Phe Gln Met Pro Pro Leu Glu Glu Gly 
        515                 520                 525             


Leu Glu Glu Leu His Ala Ser His Ile Pro Thr Ala Asn Pro Gly His 
    530                 535                 540                 


Cys Ile Thr Asp Pro Pro Ser Leu Gly Pro Gln Tyr His Pro Arg Ser 
545                 550                 555                 560 


Asn Ser Glu Ser Ser Thr Ser Ser Gly Glu Asp Tyr Cys Asn Ser Pro 
                565                 570                 575     


Lys Ser Lys Leu Pro Pro Trp Asn Pro Gln Val Phe Ser Ser Glu Arg 
            580                 585                 590         


Ser Ser Phe Leu Glu Gln Pro Pro Asn Leu Glu Leu Ala Gly Thr Gln 
        595                 600                 605             


Pro Ala Phe Ser Ala Gly Pro Pro Ala Asp Asp Ser Ser Ser Thr Ser 
    610                 615                 620                 


Ser Gly Glu Trp Tyr Gln Asn Phe Gln Pro Pro Pro Gln Pro Pro Ser 
625                 630                 635                 640 


Glu Glu Gln Phe Gly Cys Pro Gly Ser Pro Ser Pro Gln Pro Asp Ser 
                645                 650                 655     


Thr Asp Asn Asp Asp Tyr Asp Asp Ile Ser Ala Ala 
            660                 665             


<210>  8
<211>  601
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Trp Leu Phe Phe Gly Ile Thr Gly Leu Leu Thr Ala Ala Leu Ser 
1               5                   10                  15      


Gly His Pro Ser Pro Ala Pro Pro Asp Gln Leu Asn Thr Ser Ser Ala 
            20                  25                  30          


Glu Ser Glu Leu Trp Glu Pro Gly Glu Arg Leu Pro Val Arg Leu Thr 
        35                  40                  45              


Asn Gly Ser Ser Ser Cys Ser Gly Thr Val Glu Val Arg Leu Glu Ala 
    50                  55                  60                  


Ser Trp Glu Pro Ala Cys Gly Ala Leu Trp Asp Ser Arg Ala Ala Glu 
65                  70                  75                  80  


Ala Val Cys Arg Ala Leu Gly Cys Gly Gly Ala Glu Ala Ala Ser Gln 
                85                  90                  95      


Leu Ala Pro Pro Thr Pro Glu Leu Pro Pro Pro Pro Ala Ala Gly Asn 
            100                 105                 110         


Thr Ser Val Ala Ala Asn Ala Thr Leu Ala Gly Ala Pro Ala Leu Leu 
        115                 120                 125             


Cys Ser Gly Ala Glu Trp Arg Leu Cys Glu Val Val Glu His Ala Cys 
    130                 135                 140                 


Arg Ser Asp Gly Arg Arg Ala Arg Val Thr Cys Ala Glu Asn Arg Ala 
145                 150                 155                 160 


Leu Arg Leu Val Asp Gly Gly Gly Ala Cys Ala Gly Arg Val Glu Met 
                165                 170                 175     


Leu Glu His Gly Glu Trp Gly Ser Val Cys Asp Asp Thr Trp Asp Leu 
            180                 185                 190         


Glu Asp Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Val 
        195                 200                 205             


Gln Ala Leu Pro Gly Leu His Phe Thr Pro Gly Arg Gly Pro Ile His 
    210                 215                 220                 


Arg Asp Gln Val Asn Cys Ser Gly Ala Glu Ala Tyr Leu Trp Asp Cys 
225                 230                 235                 240 


Pro Gly Leu Pro Gly Gln His Tyr Cys Gly His Lys Glu Asp Ala Gly 
                245                 250                 255     


Ala Val Cys Ser Glu His Gln Ser Trp Arg Leu Thr Gly Gly Ala Asp 
            260                 265                 270         


Arg Cys Glu Gly Gln Val Glu Val His Phe Arg Gly Val Trp Asn Thr 
        275                 280                 285             


Val Cys Asp Ser Glu Trp Tyr Pro Ser Glu Ala Lys Val Leu Cys Gln 
    290                 295                 300                 


Ser Leu Gly Cys Gly Thr Ala Val Glu Arg Pro Lys Gly Leu Pro His 
305                 310                 315                 320 


Ser Leu Ser Gly Arg Met Tyr Tyr Ser Cys Asn Gly Glu Glu Leu Thr 
                325                 330                 335     


Leu Ser Asn Cys Ser Trp Arg Phe Asn Asn Ser Asn Leu Cys Ser Gln 
            340                 345                 350         


Ser Leu Ala Ala Arg Val Leu Cys Ser Ala Ser Arg Ser Leu His Asn 
        355                 360                 365             


Leu Ser Thr Pro Glu Val Pro Ala Ser Val Gln Thr Val Thr Ile Glu 
    370                 375                 380                 


Ser Ser Val Thr Val Lys Ile Glu Asn Lys Glu Ser Arg Glu Leu Met 
385                 390                 395                 400 


Leu Leu Ile Pro Ser Ile Val Leu Gly Ile Leu Leu Leu Gly Ser Leu 
                405                 410                 415     


Ile Phe Ile Ala Phe Ile Leu Leu Arg Ile Lys Gly Lys Tyr Val Phe 
            420                 425                 430         


Met Leu Pro Ile Gln Val Gln Ala Pro Pro Pro Glu Asp Ser Asp Ser 
        435                 440                 445             


Gly Ser Asp Ser Asp Tyr Glu His Tyr Asp Phe Ser Ala Gln Pro Pro 
    450                 455                 460                 


Val Ala Leu Thr Thr Phe Tyr Asn Ser Gln Arg His Arg Val Thr Asp 
465                 470                 475                 480 


Glu Glu Val Gln Gln Ser Arg Phe Gln Met Pro Pro Leu Glu Glu Gly 
                485                 490                 495     


Leu Glu Glu Leu His Ala Ser His Ile Pro Thr Ala Asn Pro Gly His 
            500                 505                 510         


Cys Ile Thr Asp Pro Pro Ser Leu Gly Pro Gln Tyr His Pro Arg Ser 
        515                 520                 525             


Asn Ser Glu Ser Ser Thr Ser Ser Gly Glu Asp Tyr Cys Asn Ser Pro 
    530                 535                 540                 


Lys Ser Lys Leu Pro Pro Trp Asn Pro Gln Val Phe Ser Ser Glu Arg 
545                 550                 555                 560 


Ser Ser Phe Leu Glu Gln Pro Pro Asn Leu Glu Leu Ala Gly Thr Gln 
                565                 570                 575     


Pro Ala Phe Ser Gly Ser Pro Ser Pro Gln Pro Asp Ser Thr Asp Asn 
            580                 585                 590         


Asp Asp Tyr Asp Asp Ile Ser Ala Ala 
        595                 600     


<210>  9
<211>  592
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Trp Leu Phe Phe Gly Ile Thr Gly Leu Leu Thr Ala Ala Leu Ser 
1               5                   10                  15      


Gly His Pro Ser Pro Ala Pro Pro Asp Gln Leu Asn Thr Ser Ser Ala 
            20                  25                  30          


Glu Ser Glu Leu Trp Glu Pro Gly Glu Arg Leu Pro Val Arg Leu Thr 
        35                  40                  45              


Asn Gly Ser Ser Ser Cys Ser Gly Thr Val Glu Val Arg Leu Glu Ala 
    50                  55                  60                  


Ser Trp Glu Pro Ala Cys Gly Ala Leu Trp Asp Ser Arg Ala Ala Glu 
65                  70                  75                  80  


Ala Val Cys Arg Ala Leu Gly Cys Gly Gly Ala Glu Ala Ala Ser Gln 
                85                  90                  95      


Leu Ala Pro Pro Thr Pro Glu Leu Pro Pro Pro Pro Ala Ala Gly Asn 
            100                 105                 110         


Thr Ser Val Ala Ala Asn Ala Thr Leu Ala Gly Ala Pro Ala Leu Leu 
        115                 120                 125             


Cys Ser Gly Ala Glu Trp Arg Leu Cys Glu Val Val Glu His Ala Cys 
    130                 135                 140                 


Arg Ser Asp Gly Arg Arg Ala Arg Val Thr Cys Ala Glu Asn Arg Ala 
145                 150                 155                 160 


Leu Arg Leu Val Asp Gly Gly Gly Ala Cys Ala Gly Arg Val Glu Met 
                165                 170                 175     


Leu Glu His Gly Glu Trp Gly Ser Val Cys Asp Asp Thr Trp Asp Leu 
            180                 185                 190         


Glu Asp Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Val 
        195                 200                 205             


Gln Ala Leu Pro Gly Leu His Phe Thr Pro Gly Arg Gly Pro Ile His 
    210                 215                 220                 


Arg Asp Gln Val Asn Cys Ser Gly Ala Glu Ala Tyr Leu Trp Asp Cys 
225                 230                 235                 240 


Pro Gly Leu Pro Gly Gln His Tyr Cys Gly His Lys Glu Asp Ala Gly 
                245                 250                 255     


Ala Val Cys Ser Glu His Gln Ser Trp Arg Leu Thr Gly Gly Ala Asp 
            260                 265                 270         


Arg Cys Glu Gly Gln Val Glu Val His Phe Arg Gly Val Trp Asn Thr 
        275                 280                 285             


Val Cys Asp Ser Glu Trp Tyr Pro Ser Glu Ala Lys Val Leu Cys Gln 
    290                 295                 300                 


Ser Leu Gly Cys Gly Thr Ala Val Glu Arg Pro Lys Gly Leu Pro His 
305                 310                 315                 320 


Ser Leu Ser Gly Arg Met Tyr Tyr Ser Cys Asn Gly Glu Glu Leu Thr 
                325                 330                 335     


Leu Ser Asn Cys Ser Trp Arg Phe Asn Asn Ser Asn Leu Cys Ser Gln 
            340                 345                 350         


Ser Leu Ala Ala Arg Val Leu Cys Ser Ala Ser Arg Ser Leu His Asn 
        355                 360                 365             


Leu Ser Thr Pro Glu Val Pro Ala Ser Val Gln Thr Val Thr Ile Glu 
    370                 375                 380                 


Ser Ser Val Thr Val Lys Ile Glu Asn Lys Glu Ser Arg Glu Leu Met 
385                 390                 395                 400 


Leu Leu Ile Pro Ser Ile Val Leu Gly Ile Leu Leu Leu Gly Ser Leu 
                405                 410                 415     


Ile Phe Ile Ala Phe Ile Leu Leu Arg Ile Lys Gly Lys Tyr Ala Leu 
            420                 425                 430         


Pro Val Met Val Asn His Gln His Leu Pro Thr Thr Ile Pro Ala Gly 
        435                 440                 445             


Ser Asn Ser Tyr Gln Pro Val Pro Ile Thr Ile Pro Lys Glu Asp Ser 
    450                 455                 460                 


Gln Arg His Arg Val Thr Asp Glu Glu Val Gln Gln Ser Arg Phe Gln 
465                 470                 475                 480 


Met Pro Pro Leu Glu Glu Gly Leu Glu Glu Leu His Ala Ser His Ile 
                485                 490                 495     


Pro Thr Ala Asn Pro Gly His Cys Ile Thr Asp Pro Pro Ser Leu Gly 
            500                 505                 510         


Pro Gln Tyr His Pro Arg Ser Asn Ser Glu Ser Ser Thr Ser Ser Gly 
        515                 520                 525             


Glu Asp Tyr Cys Asn Ser Pro Lys Ser Lys Leu Pro Pro Trp Asn Pro 
    530                 535                 540                 


Gln Val Phe Ser Ser Glu Arg Ser Ser Phe Leu Glu Gln Pro Pro Asn 
545                 550                 555                 560 


Leu Glu Leu Ala Gly Thr Gln Pro Ala Phe Ser Gly Ser Pro Ser Pro 
                565                 570                 575     


Gln Pro Asp Ser Thr Asp Asn Asp Asp Tyr Asp Asp Ile Ser Ala Ala 
            580                 585                 590         


<210>  10
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Arg Asp Ile Arg Ser Tyr 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Thr Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala 
            100                 105                 


<210>  11
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Lys Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Asp Leu Asp Tyr Phe Asp Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  12
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu 
1               5                   10                  15      


His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys 
            20                  25                  30          


Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu 
        35                  40                  45              


Lys Trp Trp Glu Leu Arg 
    50                  


<210>  13
<211>  5969
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  13
acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat       60

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      120

gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtccgcc      180

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      240

acgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat      300

gcggttttgg cagtacacca atgggcgtgg atagcggttt gactcacggg gatttccaag      360

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc      420

aaaatgtcgt aataaccccg ccccgttgac gcaaatgggc ggtaggcgtg tacggtggga      480

ggtctatata agcagagctc gtttagtgaa ccgtcagatc ctcactctct tccgcatcgc      540

tgtctgcgag ggccagctgt tgggctcgcg gttgaggaca aactcttcgc ggtctttcca      600

gtactcttgg atcggaaacc cgtcggcctc cgaacggtac tccgccaccg agggacctga      660

gcgagtccgc atcgaccgga tcggaaaacc tctcgagaaa ggcgtctaac cagtcacagt      720

cgcaaggtag gctgagcacc gtggcgggcg gcagcgggtg gcggtcgggg ttgtttctgg      780

cggaggtgct gctgatgatg taattaaagt aggcggtctt gagacggcgg atggtcgagg      840

tgaggtgtgg caggcttgag atccagctgt tggggtgagt actccctctc aaaagcgggc      900

attacttctg cgctaagatt gtcagtttcc aaaaacgagg aggatttgat attcacctgg      960

cccgatctgg ccatacactt gagtgacaat gacatccact ttgcctttct ctccacaggt     1020

gtccactccc aggggagctt gcttgttctt tttgcagaag ctcagaataa acgctcaact     1080

ttggccgcca ccatggacat gagggtcccc gctcagctcc tggggctcct gctgctctgg     1140

ctcccaggtg ccaaatgtga catccagatg acccagtccc ctattctgct gagcgcctcc     1200

gtgggcgacc gcgtgaccat cacttgcaaa gcctcccggg atatccggtc ctacctcacc     1260

tggtaccagc agaggactaa cggatcgccc agaaccctga tctactacgc gactagcctg     1320

gccgatggcg tcccgtcccg gttctcgggg tcgggttcag gacaggacta tagccttacc     1380

atctcatccc tggagtccga tgacatcgcc gactactact gcctgcaaca cggcgaatct     1440

cccttcacgt tggggtccgg aaccaagctc gagattaagc gaactgtggc tgcaccatct     1500

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc     1560

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc     1620

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc     1680

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc     1740

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt     1800

taatagctct taaaaaattc cgcccccccc ctaacgttac tggccgaagc cgcttggaat     1860

aaggccggtg tgcgtttgtc tatatgttat tttccaccat attgccgtct tttggcaatg     1920

tgagggcccg gaaacctggc cctgtcttct tgacgagcat tcctaggggt ctttcccctc     1980

tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga agcagttcct ctggaagctt     2040

cttgaagaca aacaacgtct gtagcgaccc tttgcaggca gcggaacccc ccacctggcg     2100

acaggtgcct ctgcggccaa aagccacgtg tataagatac acctgcaaag gcggcacaac     2160

cccagtgcca cgttgtgagt tggatagttg tggaaagagt caaatggctc tcctcaagcg     2220

tattcaacaa ggggctgaag gatgcccaga aggtacccca ttgtatggga tctgatctgg     2280

ggcctcggta cacatgcttt acatgtgttt agtcgaggtt aaaaaacgtc taggcccccc     2340

gaaccacggg gacgtggttt tcctttgaaa aacacgatga taatatggcc acaaccatgg     2400

gctggtccct gatcctgctg ttcctggtgg ccgtggccac gcgtgtgctg tcagaggtgc     2460

agcttgtgga atcgggtggc ggactggtca agcctggggg atcgctgaaa ctgagctgtg     2520

cagccagcgg tttcaagttc tcacgctacg ccatgtcctg ggtcagacag gcgccgggaa     2580

agcgcctgga atgggtggct actatctcct ccggcggatc ctacatctac taccccgact     2640

ccgtgaaggg ccggttcacc attagccgcg acaacgtgaa gaacactctg tacctccaaa     2700

tgtcaagcct gaggtctgag gataccgcca tctactattg cgcccggcgg gactacgact     2760

tggattactt tgactcctgg ggccagggga ccctcgtgac cgtgtcctcg gccagcacca     2820

agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg ggcacagcgg     2880

ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg tggaactcag     2940

gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca ggactctact     3000

ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc tacatctgca     3060

acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc aaatcttgtg     3120

acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga ccgtcagtct     3180

tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct gaggtcacat     3240

gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg     3300

gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac agcacgtacc     3360

gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag gagtacaagt     3420

gcaaggtcag caacaaagcc ctcccagccc ccatcgagaa aaccatctcc aaagccaaag     3480

ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga     3540

accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc gccgtggagt     3600

gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg ctggactccg     3660

acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg cagcagggga     3720

acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg cagaagtccc     3780

tctccctgtc tccgggtaaa taggcggccg ctaaaagcgg ccgctcgagg ccggcaaggc     3840

cggatccccc gacctctggc taataaagga aatttatttt cattgcaata gtgtgttgga     3900

attttttgtg tctctcactc ggaaggacat atgggagggc aaatcattta aaacatcaga     3960

atgagtattt ggtttagagt ttggcaacat atgcccatat gctggctgcc atgaacaaag     4020

gttggctata aagaggtcat cagtatatga aacagccccc tgctgtccat tccttattcc     4080

atagaaaagc cttgacttga ggttagattt tttttatatt ttgttttgtg ttattttttt     4140

ctttaacatc cctaaaattt tccttacatg ttttactagc cagatttttc ctcctctcct     4200

gactactccc agtcatagct gtccctcttc tcttatggag atctcagcct tgagcggtat     4260

cagctcactc aaaggcggta atacggttat ccacagaatc aggggataac gcaggaaaga     4320

acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt     4380

ttttccatag gctccgcccc cctgacgagc atcacaaaaa tcgacgctca agtcagaggt     4440

ggcgaaaccc gacaggacta taaagatacc aggcgtttcc ccctggaagc tccctcgtgc     4500

gctctcctgt tccgaccctg ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa     4560

gcgtggcgct ttctcatagc tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct     4620

ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc ttatccggta     4680

actatcgtct tgagtccaac ccggtaagac acgacttatc gccactggca gcagccactg     4740

gtaacaggat tagcagagcg aggtatgtag gcggtgctac agagttcttg aagtggtggg     4800

ctaactacgg ctacactaga agaacagtat ttggtatctg cgctctgctg aagccagtta     4860

ccttcggaaa aagagttggt agctcttgat ccggcaaaca aaccaccgct ggtagcggtg     4920

gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa gaagatcctt     4980

tgatcttttc tacggggtct gacgctcagt ggaacgacgc gcgcgtaact cacgttaagg     5040

gattttggtc atgagttaga aaaactcatc gagcatcaaa tgaaactgca atttattcat     5100

atcaggatta tcaataccat atttttgaaa aagccgtttc tgtaatgaag gagaaaactc     5160

accgaggcag ttccatagga tggcaagatc ctggtatcgg tctgcgattc cgactcgtcc     5220

aacatcaata caacctatta atttcccctc gtcaaaaata aggttatcaa gtgagaaatc     5280

accatgagtg acgactgaat ccggtgagaa tggcaaaagt ttatgcattt ctttccagac     5340

ttgttcaaca ggccagccat tacgctcgtc atcaaaatca ctcgcatcaa ccaaaccgtt     5400

attcattcgt gattgcgcct gagcgaggcg aaatacgcga tcgctgttaa aaggacaatt     5460

acaaacagga atcgagtgca accggcgcag gaacactgcc agcgcatcaa caatattttc     5520

acctgaatca ggatattctt ctaatacctg gaacgctgtt tttccgggga tcgcagtggt     5580

gagtaaccat gcatcatcag gagtacggat aaaatgcttg atggtcggaa gtggcataaa     5640

ttccgtcagc cagtttagtc tgaccatctc atctgtaaca tcattggcaa cgctaccttt     5700

gccatgtttc agaaacaact ctggcgcatc gggcttccca tacaagcgat agattgtcgc     5760

acctgattgc ccgacattat cgcgagccca tttataccca tataaatcag catccatgtt     5820

ggaatttaat cgcggcctcg acgtttcccg ttggatatgg ctcatttttt acttcctcac     5880

cttgtcgtat tatactatgc cgatatacta tgccgatgat taattgtcga cactgcgggg     5940

gctctatata tggagttccg cgttacata                                       5969


<210>  14
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  14

Val Arg Leu Thr Asn Gly Ser Ser Ser Cys Ser Gly Thr Val Glu Val 
1               5                   10                  15      


Arg Leu Glu Ala Ser Trp Glu Pro Ala Cys Gly Ala Leu Trp Asp Ser 
            20                  25                  30          


Arg Ala Ala Glu Ala Val Cys Arg Ala Leu Gly Cys Gly Gly Ala Glu 
        35                  40                  45              


Ala Ala Ser Gln Leu Ala Pro Pro Thr Pro Glu Leu Pro Pro Pro Pro 
    50                  55                  60                  


Ala Ala Gly Asn Thr Ser Val Ala Ala Asn Ala Thr Leu Ala Gly Ala 
65                  70                  75                  80  


Pro Ala Leu Leu Cys Ser Gly Ala Glu Trp Arg Leu Cys Glu Val Val 
                85                  90                  95      


Glu His Ala Cys Arg Ser Asp Gly Arg Arg Ala Arg Val Thr Cys Ala 
            100                 105                 110         


<210>  15
<211>  60
<212>  DNA
<213>  Homo sapiens

<400>  15
gtccaacttg ttgaatcagg tggggggctg gtcaaacccg ggggctctct gaaactaagt       60


<210>  16
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  16
ttctctcggt acgctatgtc gtgggtcaga caagcgcccg gcaaa                       45


<210>  17
<211>  57
<212>  DNA
<213>  Homo sapiens

<400>  17
cgtgattatg atctagacta ctttgactcc tggggtcaag gtacgctcgt gacggtt          57


<210>  18
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  18

Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser 
1               5                   10                  15      


Leu Lys Leu Ser 
            20  


<210>  19
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  19

Phe Ser Arg Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
1               5                   10                  15  


<210>  20
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  20

Arg Asp Tyr Asp Leu Asp Tyr Phe Asp Ser Trp Gly Gln Gly Thr Leu 
1               5                   10                  15      


Val Thr Val 
            


<210>  21
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Arg 
1               5                   10                  15      


Val Leu Ser His Pro Ser Pro Ala Pro Pro Asp Gln Leu Asn Thr Ser 
            20                  25                  30          


Ser Ala Glu Ser Glu Leu Trp Glu Pro Gly Glu Arg Leu Pro Val Arg 
        35                  40                  45              


Leu Thr Asn Gly Ser Ser Ser Cys Ser Gly Thr Val Glu Val Arg Leu 
    50                  55                  60                  


Glu Ala Ser Trp Glu Pro Ala Cys Gly Ala Leu Trp Asp Ser Arg Ala 
65                  70                  75                  80  


Ala Glu Ala Val Cys Arg Ala Leu Gly Cys Gly Gly Ala Glu Ala Ala 
                85                  90                  95      


Ser Gln Leu Ala Pro Pro Thr Pro Glu Leu Pro Pro Pro Pro Ala Ala 
            100                 105                 110         


Gly Asn Thr Ser Val Ala Ala Asn Ala Thr Leu Ala Gly Ala Pro Ala 
        115                 120                 125             


Leu Leu Cys Ser Gly Ala Glu Trp Arg Leu Cys Glu Val Val Glu His 
    130                 135                 140                 


Ala Cys Arg Ser Asp Gly Arg Arg Ala Arg Val Thr Cys Ala Glu Asn 
145                 150                 155                 160 


Arg Ala Leu Arg Leu Val Asp Gly Gly Gly Ala Cys Ala Gly Arg Val 
                165                 170                 175     


Glu Met Leu Glu His Gly Glu Trp Gly Ser Val Cys Asp Asp Thr Trp 
            180                 185                 190         


Asp Leu Glu Asp Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Trp 
        195                 200                 205             


Ala Val Gln Ala Leu Pro Gly Leu His Phe Thr Pro Gly Arg Gly Pro 
    210                 215                 220                 


Ile His Arg Asp Gln Val Asn Cys Ser Gly Ala Glu Ala Tyr Leu Trp 
225                 230                 235                 240 


Asp Cys Pro Gly Leu Pro Gly Gln His Tyr Cys Gly His Lys Glu Asp 
                245                 250                 255     


Ala Gly Val Val Cys Ser Glu His Gln Ser Trp Arg Leu Thr Gly Gly 
            260                 265                 270         


Ala Asp Arg Cys Glu Gly Gln Val Glu Val His Phe Arg Gly Val Trp 
        275                 280                 285             


Asn Thr Val Cys Asp Ser Glu Trp Tyr Pro Ser Glu Ala Lys Val Leu 
    290                 295                 300                 


Cys Gln Ser Leu Gly Cys Gly Thr Ala Val Glu Arg Pro Lys Gly Leu 
305                 310                 315                 320 


Pro His Ser Leu Ser Gly Arg Met Tyr Tyr Ser Cys Asn Gly Glu Glu 
                325                 330                 335     


Leu Thr Leu Ser Asn Cys Ser Trp Arg Phe Asn Asn Ser Asn Leu Cys 
            340                 345                 350         


Ser Gln Ser Leu Ala Ala Arg Val Leu Cys Ser Ala Ser Arg Gly His 
        355                 360                 365             


His His His His His 
    370             


<210>  22
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  22

Cys Gln Phe Asp Leu Ser Thr Arg Arg Leu Lys Cys 
1               5                   10          


<210>  23
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  23

Cys Gln Tyr Asn Leu Ser Ser Arg Ala Leu Lys Cys 
1               5                   10          


<210>  24
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  24

Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Lys Ala Ser Arg Asp Ile Arg Ser Tyr Leu 
            20                  25                  30          


Thr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile Tyr 
        35                  40                  45              


Tyr Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Gln 
65              


<210>  25
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Arg Asp Ile Arg Ser Tyr 
            20                  25                  30          


<210>  26
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  26

Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
1               5                   10                  15      


Tyr Tyr Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
            20                  25                  30          


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
        35                  40                  45              


Asp Asp Thr Ala Thr Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Phe 
    50                  55                  60                  


Thr 
65  


<210>  27
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  27

Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala 
1               5                   10          


<210>  28
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  28

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Lys Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Ser 
        35  


<210>  29
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  29

Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val Ala Thr Ile 
1               5                   10                  15      


Ser Ser Gly Gly 
            20  


<210>  30
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  30

Ser Tyr Ile Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
1               5                   10                  15      


Arg Asp Asn Val Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg 
            20                  25                  30          


Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Arg Asp Tyr Asp Leu 
        35                  40                  45              


Asp Tyr Phe Asp Ser 
    50              


<210>  31
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  31

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  32
<211>  745
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  32

Asp Ile Gln Met Thr Gln Ser Pro Ile Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Arg Asp Ile Arg Ser Tyr 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Thr Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Asp Asp Ile Ala Asp Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Ala Ser Ala Ser Ala Ala Ala Ser Ser Ala 
    210                 215                 220                 


Ser Ser Ala Ala Ser Ser Asn Ser Asp Ser Glu Cys Pro Leu Ser His 
225                 230                 235                 240 


Asp Gly Tyr Cys Leu His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu 
                245                 250                 255     


Asp Lys Tyr Ala Cys Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys 
            260                 265                 270         


Gln Tyr Arg Asp Leu Lys Trp Trp Glu Leu Arg Gly Ser Gly Val Leu 
        275                 280                 285             


Pro Ala Ser Leu Tyr Ser Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
    290                 295                 300                 


Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala 
305                 310                 315                 320 


Ser Gly Phe Lys Phe Ser Arg Tyr Ala Met Ser Trp Val Arg Gln Ala 
                325                 330                 335     


Pro Gly Lys Arg Leu Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Ser 
            340                 345                 350         


Tyr Ile Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Val Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser 
    370                 375                 380                 


Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Arg Asp Tyr Asp Leu Asp 
385                 390                 395                 400 


Tyr Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
                405                 410                 415     


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
            420                 425                 430         


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
        435                 440                 445             


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
    450                 455                 460                 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
465                 470                 475                 480 


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
                485                 490                 495     


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
            500                 505                 510         


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        515                 520                 525             


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    530                 535                 540                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
545                 550                 555                 560 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                565                 570                 575     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            580                 585                 590         


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        595                 600                 605             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    610                 615                 620                 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
625                 630                 635                 640 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
                645                 650                 655     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            660                 665                 670         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        675                 680                 685             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    690                 695                 700                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
705                 710                 715                 720 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                725                 730                 735     


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            740                 745 


<210>  33
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  33

Asp Ile Gln Met Thr Gln Ser Pro Ile Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Arg Asp Ile Arg Ser Tyr 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Thr Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Asp Asp Ile Ala Asp Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  34
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  34

Ala Ser Ala Ser Ala Ala Ala Ser Ser Ala Ser Ser Ala Ala Ser Ser 
1               5                   10                  15      


<210>  35
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  35

Gly Ser Gly Val Leu Pro Ala Ser Leu Tyr Ser Gly Ser 
1               5                   10              


<210>  36
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  36

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Lys Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Asp Leu Asp Tyr Phe Asp Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr 
225         


<210>  37
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  37

Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        35                  40                  45              


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220         


<210>  38
<211>  745
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  38

Asp Ile Gln Met Thr Gln Ser Pro Ile Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Arg Asp Ile Arg Ser Tyr 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Thr Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Asp Asp Ile Ala Asp Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Ala Ser Ala Ser Ala Ala Ala Ser Ser Ala 
    210                 215                 220                 


Ser Ser Ala Ala Ser Ser Asn Ser Asp Ser Glu Cys Pro Leu Ser His 
225                 230                 235                 240 


Asp Gly Tyr Cys Leu His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu 
                245                 250                 255     


Asp Lys Tyr Ala Cys Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys 
            260                 265                 270         


Gln Tyr Arg Asp Leu Lys Trp Trp Glu Leu Arg Gly Ser Gly Ser Gly 
        275                 280                 285             


Ile Glu Pro Asp Ser Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
    290                 295                 300                 


Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala 
305                 310                 315                 320 


Ser Gly Phe Lys Phe Ser Arg Tyr Ala Met Ser Trp Val Arg Gln Ala 
                325                 330                 335     


Pro Gly Lys Arg Leu Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Ser 
            340                 345                 350         


Tyr Ile Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Val Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser 
    370                 375                 380                 


Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Arg Asp Tyr Asp Leu Asp 
385                 390                 395                 400 


Tyr Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
                405                 410                 415     


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
            420                 425                 430         


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
        435                 440                 445             


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
    450                 455                 460                 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
465                 470                 475                 480 


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
                485                 490                 495     


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
            500                 505                 510         


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        515                 520                 525             


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    530                 535                 540                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
545                 550                 555                 560 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                565                 570                 575     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            580                 585                 590         


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        595                 600                 605             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    610                 615                 620                 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
625                 630                 635                 640 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
                645                 650                 655     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            660                 665                 670         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        675                 680                 685             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    690                 695                 700                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
705                 710                 715                 720 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                725                 730                 735     


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            740                 745 


<210>  39
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  39

Gly Ser Gly Ser Gly Ile Glu Pro Asp Ser Gly Gly Ser 
1               5                   10              


<210>  40
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  40

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Lys Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Asp Leu Asp Tyr Phe Asp Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr 
225         


<210>  41
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  41

Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        35                  40                  45              


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220         


<210>  42
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  42

Asp Ile Gln Met Thr Gln Ser Pro Ile Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Arg Asp Ile Arg Ser Tyr 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Thr Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Asp Asp Ile Ala Asp Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Ala Ser Ala Ser Ala Ala Ala Ser Ser Ala 
    210                 215                 220                 


Ser Ser Ala Ala Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly 
225                 230                 235                 240 


Tyr Cys Leu His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys 
                245                 250                 255     


Tyr Ala Cys Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr 
            260                 265                 270         


Arg Asp Leu Lys Trp Trp Glu Leu Arg Gly Ser Gly Ser Gly Ile Glu 
        275                 280                 285             


Pro Asp Ser Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    290                 295                 300                 


Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
305                 310                 315                 320 


Phe Lys Phe Ser Arg Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly 
                325                 330                 335     


Lys Arg Leu Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Ser Tyr Ile 
            340                 345                 350         


Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Val Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp 
    370                 375                 380                 


Thr Ala Ile Tyr Tyr Cys Ala Arg Arg Asp Tyr Asp Leu Asp Tyr Phe 
385                 390                 395                 400 


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
                405                 410                 415     


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
            420                 425                 430         


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
        435                 440                 445             


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
    450                 455                 460                 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
465                 470                 475                 480 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
                485                 490                 495     


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
            500                 505                 510         


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        515                 520                 525             


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    530                 535                 540                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
545                 550                 555                 560 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
                565                 570                 575     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
            580                 585                 590         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        595                 600                 605             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
    610                 615                 620                 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
625                 630                 635                 640 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
                645                 650                 655     


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            660                 665                 670         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        675                 680                 685             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
    690                 695                 700                 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
705                 710                 715                 720 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                725                 730                 735     


Leu Ser Leu Ser Pro Gly Lys 
            740             


<210>  43
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  43

Ala Ser Ala Ser Ala Ala Ala Ser Ser Ala Ser Ser Ala Ala 
1               5                   10                  


<210>  44
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  44

Asp Ile Gln Met Thr Gln Ser Pro Ile Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Arg Asp Ile Arg Ser Tyr 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Thr Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Asp Asp Ile Ala Asp Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Ala Ser Ala Ser Ala Ala Ala Ser Ser Ala 
    210                 215                 220                 


Ser Ser Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys 
225                 230                 235                 240 


Leu His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala 
                245                 250                 255     


Cys Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp 
            260                 265                 270         


Leu Lys Trp Trp Glu Leu Arg Gly Ser Gly Ser Gly Ile Glu Pro Asp 
        275                 280                 285             


Ser Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    290                 295                 300                 


Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Lys 
305                 310                 315                 320 


Phe Ser Arg Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg 
                325                 330                 335     


Leu Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr 
            340                 345                 350         


Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys 
        355                 360                 365             


Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala 
    370                 375                 380                 


Ile Tyr Tyr Cys Ala Arg Arg Asp Tyr Asp Leu Asp Tyr Phe Asp Ser 
385                 390                 395                 400 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
                405                 410                 415     


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
            420                 425                 430         


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
        435                 440                 445             


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
    450                 455                 460                 


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
465                 470                 475                 480 


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
                485                 490                 495     


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
            500                 505                 510         


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        515                 520                 525             


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    530                 535                 540                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
545                 550                 555                 560 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                565                 570                 575     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            580                 585                 590         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        595                 600                 605             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    610                 615                 620                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
625                 630                 635                 640 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                645                 650                 655     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            660                 665                 670         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        675                 680                 685             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    690                 695                 700                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
705                 710                 715                 720 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                725                 730                 735     


Leu Ser Pro Gly Lys 
            740     


<210>  45
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  45

Ala Ser Ala Ser Ala Ala Ala Ser Ser Ala Ser Ser 
1               5                   10          


<210>  46
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  46

Asp Ile Gln Met Thr Gln Ser Pro Ile Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Arg Asp Ile Arg Ser Tyr 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Thr Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Asp Asp Ile Ala Asp Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Ala Ser Ala Ser Ala Ala Ala Ser Ser Ala 
    210                 215                 220                 


Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu His 
225                 230                 235                 240 


Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys Asn 
                245                 250                 255     


Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu Lys 
            260                 265                 270         


Trp Trp Glu Leu Arg Gly Ser Gly Ser Gly Ile Glu Pro Asp Ser Gly 
        275                 280                 285             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro 
    290                 295                 300                 


Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Lys Phe Ser 
305                 310                 315                 320 


Arg Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu 
                325                 330                 335     


Trp Val Ala Thr Ile Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Pro Asp 
            340                 345                 350         


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Asn Thr 
        355                 360                 365             


Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr 
    370                 375                 380                 


Tyr Cys Ala Arg Arg Asp Tyr Asp Leu Asp Tyr Phe Asp Ser Trp Gly 
385                 390                 395                 400 


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
                405                 410                 415     


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
            420                 425                 430         


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
        435                 440                 445             


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
    450                 455                 460                 


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
465                 470                 475                 480 


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
                485                 490                 495     


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
            500                 505                 510         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        515                 520                 525             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    530                 535                 540                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
545                 550                 555                 560 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                565                 570                 575     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            580                 585                 590         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        595                 600                 605             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    610                 615                 620                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
625                 630                 635                 640 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                645                 650                 655     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            660                 665                 670         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        675                 680                 685             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    690                 695                 700                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
705                 710                 715                 720 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                725                 730                 735     


Pro Gly Lys 
            


<210>  47
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  47

Ala Ser Ala Ser Ala Ala Ala Ser Ser Ala 
1               5                   10  


<210>  48
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  48

Asp Ile Gln Met Thr Gln Ser Pro Ile Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Arg Asp Ile Arg Ser Tyr 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Thr Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Asp Asp Ile Ala Asp Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Ala Ser Ala Ser Ala Ala Ala Ser Asn Ser 
    210                 215                 220                 


Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu His Asp Gly 
225                 230                 235                 240 


Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys Asn Cys Val 
                245                 250                 255     


Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu Lys Trp Trp 
            260                 265                 270         


Glu Leu Arg Gly Ser Gly Ser Gly Ile Glu Pro Asp Ser Gly Gly Ser 
        275                 280                 285             


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
    290                 295                 300                 


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Lys Phe Ser Arg Tyr 
305                 310                 315                 320 


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
                325                 330                 335     


Ala Thr Ile Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Pro Asp Ser Val 
            340                 345                 350         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Asn Thr Leu Tyr 
        355                 360                 365             


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
    370                 375                 380                 


Ala Arg Arg Asp Tyr Asp Leu Asp Tyr Phe Asp Ser Trp Gly Gln Gly 
385                 390                 395                 400 


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
                405                 410                 415     


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
            420                 425                 430         


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
        435                 440                 445             


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
    450                 455                 460                 


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
465                 470                 475                 480 


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
                485                 490                 495     


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
            500                 505                 510         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        515                 520                 525             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    530                 535                 540                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
545                 550                 555                 560 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                565                 570                 575     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            580                 585                 590         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        595                 600                 605             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    610                 615                 620                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
625                 630                 635                 640 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
                645                 650                 655     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            660                 665                 670         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        675                 680                 685             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    690                 695                 700                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
705                 710                 715                 720 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                725                 730                 735     


Lys 
    


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  49

Ala Ser Ala Ser Ala Ala Ala Ser 
1               5               


<210>  50
<211>  745
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  50

Asp Ile Gln Met Thr Gln Ser Pro Ile Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Arg Asp Ile Arg Ser Tyr 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Thr Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Asp Asp Ile Ala Asp Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Ala Ser Ala Ser Ala Ala Ala Ser Ser Ala 
    210                 215                 220                 


Ser Ser Ala Ala Pro Pro Asn Ser Asp Ser Glu Cys Pro Leu Ser His 
225                 230                 235                 240 


Asp Gly Tyr Cys Leu His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu 
                245                 250                 255     


Asp Lys Tyr Ala Cys Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys 
            260                 265                 270         


Gln Tyr Arg Asp Leu Lys Trp Trp Glu Leu Arg Gly Ser Gly Ser Gly 
        275                 280                 285             


Ile Glu Pro Asp Ser Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
    290                 295                 300                 


Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala 
305                 310                 315                 320 


Ser Gly Phe Lys Phe Ser Arg Tyr Ala Met Ser Trp Val Arg Gln Ala 
                325                 330                 335     


Pro Gly Lys Arg Leu Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Ser 
            340                 345                 350         


Tyr Ile Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Val Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser 
    370                 375                 380                 


Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Arg Asp Tyr Asp Leu Asp 
385                 390                 395                 400 


Tyr Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
                405                 410                 415     


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
            420                 425                 430         


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
        435                 440                 445             


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
    450                 455                 460                 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
465                 470                 475                 480 


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
                485                 490                 495     


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
            500                 505                 510         


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        515                 520                 525             


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    530                 535                 540                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
545                 550                 555                 560 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                565                 570                 575     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            580                 585                 590         


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        595                 600                 605             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    610                 615                 620                 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
625                 630                 635                 640 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
                645                 650                 655     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            660                 665                 670         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        675                 680                 685             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    690                 695                 700                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
705                 710                 715                 720 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                725                 730                 735     


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            740                 745 


<210>  51
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  51

Ala Ser Ala Ser Ala Ala Ala Ser Ser Ala Ser Ser Ala Ala Pro Pro 
1               5                   10                  15      


<210>  52
<211>  745
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  52

Asp Ile Gln Met Thr Gln Ser Pro Ile Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Arg Asp Ile Arg Ser Tyr 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Thr Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Asp Asp Ile Ala Asp Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Pro Pro Ala Ser Ala Ala Ala Ser Ser Ala 
    210                 215                 220                 


Ser Ser Ala Ala Ser Ser Asn Ser Asp Ser Glu Cys Pro Leu Ser His 
225                 230                 235                 240 


Asp Gly Tyr Cys Leu His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu 
                245                 250                 255     


Asp Lys Tyr Ala Cys Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys 
            260                 265                 270         


Gln Tyr Arg Asp Leu Lys Trp Trp Glu Leu Arg Gly Ser Gly Ser Gly 
        275                 280                 285             


Ile Glu Pro Asp Ser Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
    290                 295                 300                 


Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala 
305                 310                 315                 320 


Ser Gly Phe Lys Phe Ser Arg Tyr Ala Met Ser Trp Val Arg Gln Ala 
                325                 330                 335     


Pro Gly Lys Arg Leu Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Ser 
            340                 345                 350         


Tyr Ile Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Val Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser 
    370                 375                 380                 


Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Arg Asp Tyr Asp Leu Asp 
385                 390                 395                 400 


Tyr Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
                405                 410                 415     


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
            420                 425                 430         


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
        435                 440                 445             


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
    450                 455                 460                 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
465                 470                 475                 480 


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
                485                 490                 495     


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
            500                 505                 510         


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        515                 520                 525             


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    530                 535                 540                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
545                 550                 555                 560 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                565                 570                 575     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            580                 585                 590         


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        595                 600                 605             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    610                 615                 620                 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
625                 630                 635                 640 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
                645                 650                 655     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            660                 665                 670         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        675                 680                 685             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    690                 695                 700                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
705                 710                 715                 720 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                725                 730                 735     


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            740                 745 


<210>  53
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  53

Pro Pro Ala Ser Ala Ala Ala Ser Ser Ala Ser Ser Ala Ala Ser Ser 
1               5                   10                  15      


<210>  54
<211>  745
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  54

Asp Ile Gln Met Thr Gln Ser Pro Ile Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Arg Asp Ile Arg Ser Tyr 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Thr Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Asp Asp Ile Ala Asp Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Pro Pro Ala Ser Ala Ala Ala Ser Ser Ala 
    210                 215                 220                 


Ser Ser Ala Ala Pro Pro Asn Ser Asp Ser Glu Cys Pro Leu Ser His 
225                 230                 235                 240 


Asp Gly Tyr Cys Leu His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu 
                245                 250                 255     


Asp Lys Tyr Ala Cys Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys 
            260                 265                 270         


Gln Tyr Arg Asp Leu Lys Trp Trp Glu Leu Arg Gly Ser Gly Ser Gly 
        275                 280                 285             


Ile Glu Pro Asp Ser Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
    290                 295                 300                 


Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala 
305                 310                 315                 320 


Ser Gly Phe Lys Phe Ser Arg Tyr Ala Met Ser Trp Val Arg Gln Ala 
                325                 330                 335     


Pro Gly Lys Arg Leu Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Ser 
            340                 345                 350         


Tyr Ile Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Val Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser 
    370                 375                 380                 


Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Arg Asp Tyr Asp Leu Asp 
385                 390                 395                 400 


Tyr Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
                405                 410                 415     


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
            420                 425                 430         


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
        435                 440                 445             


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
    450                 455                 460                 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
465                 470                 475                 480 


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
                485                 490                 495     


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
            500                 505                 510         


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        515                 520                 525             


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    530                 535                 540                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
545                 550                 555                 560 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                565                 570                 575     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            580                 585                 590         


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        595                 600                 605             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    610                 615                 620                 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
625                 630                 635                 640 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
                645                 650                 655     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            660                 665                 670         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        675                 680                 685             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    690                 695                 700                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
705                 710                 715                 720 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                725                 730                 735     


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            740                 745 


<210>  55
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  55

Pro Pro Ala Ser Ala Ala Ala Ser Ser Ala Ser Ser Ala Ala Pro Pro 
1               5                   10                  15      


<210>  56
<211>  745
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  56

Asp Ile Gln Met Thr Gln Ser Pro Ile Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Arg Asp Ile Arg Ser Tyr 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Thr Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Asp Asp Ile Ala Asp Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Pro Pro Ala Ser Ala Ala Ala Pro Pro Ala 
    210                 215                 220                 


Ser Ser Ala Ala Pro Pro Asn Ser Asp Ser Glu Cys Pro Leu Ser His 
225                 230                 235                 240 


Asp Gly Tyr Cys Leu His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu 
                245                 250                 255     


Asp Lys Tyr Ala Cys Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys 
            260                 265                 270         


Gln Tyr Arg Asp Leu Lys Trp Trp Glu Leu Arg Gly Ser Gly Ser Gly 
        275                 280                 285             


Ile Glu Pro Asp Ser Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
    290                 295                 300                 


Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala 
305                 310                 315                 320 


Ser Gly Phe Lys Phe Ser Arg Tyr Ala Met Ser Trp Val Arg Gln Ala 
                325                 330                 335     


Pro Gly Lys Arg Leu Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Ser 
            340                 345                 350         


Tyr Ile Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Val Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser 
    370                 375                 380                 


Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Arg Asp Tyr Asp Leu Asp 
385                 390                 395                 400 


Tyr Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
                405                 410                 415     


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
            420                 425                 430         


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
        435                 440                 445             


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
    450                 455                 460                 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
465                 470                 475                 480 


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
                485                 490                 495     


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
            500                 505                 510         


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        515                 520                 525             


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    530                 535                 540                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
545                 550                 555                 560 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                565                 570                 575     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            580                 585                 590         


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        595                 600                 605             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    610                 615                 620                 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
625                 630                 635                 640 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
                645                 650                 655     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            660                 665                 670         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        675                 680                 685             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    690                 695                 700                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
705                 710                 715                 720 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                725                 730                 735     


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            740                 745 


<210>  57
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  57

Pro Pro Ala Ser Ala Ala Ala Pro Pro Ala Ser Ser Ala Ala Pro Pro 
1               5                   10                  15      


<210>  58
<211>  744
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  58

Asp Ile Gln Met Thr Gln Ser Pro Ile Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Arg Asp Ile Arg Ser Tyr 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Thr Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Asp Asp Ile Ala Asp Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Ala Ser Ala Ser Ala Ala Ala Ser Ser Ala 
    210                 215                 220                 


Ser Ser Ala Ala Ser Ser Asn Ser Asp Ser Glu Cys Pro Leu Ser His 
225                 230                 235                 240 


Asp Gly Tyr Cys Leu His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu 
                245                 250                 255     


Asp Lys Tyr Ala Cys Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys 
            260                 265                 270         


Gln Tyr Arg Asp Leu Lys Trp Trp Glu Leu Arg Ser Gly Ser Gly Ile 
        275                 280                 285             


Glu Pro Asp Ser Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Lys Phe Ser Arg Tyr Ala Met Ser Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Arg Leu Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Ser Tyr 
            340                 345                 350         


Ile Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
        355                 360                 365             


Asn Val Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu 
    370                 375                 380                 


Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Arg Asp Tyr Asp Leu Asp Tyr 
385                 390                 395                 400 


Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
                405                 410                 415     


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
            420                 425                 430         


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
        435                 440                 445             


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
    450                 455                 460                 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
465                 470                 475                 480 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
                485                 490                 495     


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
            500                 505                 510         


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        515                 520                 525             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    530                 535                 540                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
545                 550                 555                 560 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                565                 570                 575     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            580                 585                 590         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        595                 600                 605             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    610                 615                 620                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
625                 630                 635                 640 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                645                 650                 655     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            660                 665                 670         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        675                 680                 685             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    690                 695                 700                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
705                 710                 715                 720 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                725                 730                 735     


Ser Leu Ser Leu Ser Pro Gly Lys 
            740                 


<210>  59
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  59

Ser Gly Ser Gly Ile Glu Pro Asp Ser Gly Gly Ser 
1               5                   10          


<210>  60
<211>  744
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  60

Asp Ile Gln Met Thr Gln Ser Pro Ile Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Arg Asp Ile Arg Ser Tyr 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Thr Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Asp Asp Ile Ala Asp Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Ala Ser Ala Ser Ala Ala Ala Ser Ser Ala 
    210                 215                 220                 


Ser Ser Ala Ala Ser Ser Asn Ser Asp Ser Glu Cys Pro Leu Ser His 
225                 230                 235                 240 


Asp Gly Tyr Cys Leu His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu 
                245                 250                 255     


Asp Lys Tyr Ala Cys Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys 
            260                 265                 270         


Gln Tyr Arg Asp Leu Lys Trp Trp Glu Leu Arg Gly Ser Gly Ser Gly 
        275                 280                 285             


Ile Glu Pro Asp Ser Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Phe Lys Phe Ser Arg Tyr Ala Met Ser Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Arg Leu Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Ser Tyr 
            340                 345                 350         


Ile Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
        355                 360                 365             


Asn Val Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu 
    370                 375                 380                 


Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Arg Asp Tyr Asp Leu Asp Tyr 
385                 390                 395                 400 


Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
                405                 410                 415     


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
            420                 425                 430         


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
        435                 440                 445             


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
    450                 455                 460                 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
465                 470                 475                 480 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
                485                 490                 495     


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
            500                 505                 510         


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        515                 520                 525             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    530                 535                 540                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
545                 550                 555                 560 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                565                 570                 575     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            580                 585                 590         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        595                 600                 605             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    610                 615                 620                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
625                 630                 635                 640 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                645                 650                 655     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            660                 665                 670         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        675                 680                 685             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    690                 695                 700                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
705                 710                 715                 720 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                725                 730                 735     


Ser Leu Ser Leu Ser Pro Gly Lys 
            740                 


<210>  61
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  61

Gly Ser Gly Ser Gly Ile Glu Pro Asp Ser Gly Ser 
1               5                   10          


<210>  62
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  62

Asp Ile Gln Met Thr Gln Ser Pro Ile Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Arg Asp Ile Arg Ser Tyr 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Thr Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Asp Asp Ile Ala Asp Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Ala Ser Ala Ser Ala Ala Ala Ser Ser Ala 
    210                 215                 220                 


Ser Ser Ala Ala Ser Ser Asn Ser Asp Ser Glu Cys Pro Leu Ser His 
225                 230                 235                 240 


Asp Gly Tyr Cys Leu His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu 
                245                 250                 255     


Asp Lys Tyr Ala Cys Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys 
            260                 265                 270         


Gln Tyr Arg Asp Leu Lys Trp Trp Glu Leu Arg Ser Gly Ser Gly Ile 
        275                 280                 285             


Glu Pro Asp Ser Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    290                 295                 300                 


Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
305                 310                 315                 320 


Phe Lys Phe Ser Arg Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly 
                325                 330                 335     


Lys Arg Leu Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Ser Tyr Ile 
            340                 345                 350         


Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        355                 360                 365             


Val Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp 
    370                 375                 380                 


Thr Ala Ile Tyr Tyr Cys Ala Arg Arg Asp Tyr Asp Leu Asp Tyr Phe 
385                 390                 395                 400 


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
                405                 410                 415     


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
            420                 425                 430         


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
        435                 440                 445             


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
    450                 455                 460                 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
465                 470                 475                 480 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
                485                 490                 495     


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
            500                 505                 510         


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        515                 520                 525             


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    530                 535                 540                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
545                 550                 555                 560 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
                565                 570                 575     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
            580                 585                 590         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        595                 600                 605             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
    610                 615                 620                 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
625                 630                 635                 640 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
                645                 650                 655     


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            660                 665                 670         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        675                 680                 685             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
    690                 695                 700                 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
705                 710                 715                 720 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                725                 730                 735     


Leu Ser Leu Ser Pro Gly Lys 
            740             


<210>  63
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  63

Ser Gly Ser Gly Ile Glu Pro Asp Ser Gly Ser 
1               5                   10      


<210>  64
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  64

Asp Ile Gln Met Thr Gln Ser Pro Ile Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Arg Asp Ile Arg Ser Tyr 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Thr Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Asp Asp Ile Ala Asp Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Ala Ser Ala Ser Ala Ala Ala Ser Ser Ala 
    210                 215                 220                 


Ser Ser Ala Ala Ser Ser Asn Ser Asp Ser Glu Cys Pro Leu Ser His 
225                 230                 235                 240 


Asp Gly Tyr Cys Leu His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu 
                245                 250                 255     


Asp Lys Tyr Ala Cys Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys 
            260                 265                 270         


Gln Tyr Arg Asp Leu Lys Trp Trp Glu Leu Arg Gly Ser Gly Ile Glu 
        275                 280                 285             


Pro Asp Ser Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    290                 295                 300                 


Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Lys 
305                 310                 315                 320 


Phe Ser Arg Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg 
                325                 330                 335     


Leu Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr 
            340                 345                 350         


Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys 
        355                 360                 365             


Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala 
    370                 375                 380                 


Ile Tyr Tyr Cys Ala Arg Arg Asp Tyr Asp Leu Asp Tyr Phe Asp Ser 
385                 390                 395                 400 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
                405                 410                 415     


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
            420                 425                 430         


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
        435                 440                 445             


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
    450                 455                 460                 


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
465                 470                 475                 480 


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
                485                 490                 495     


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
            500                 505                 510         


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        515                 520                 525             


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    530                 535                 540                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
545                 550                 555                 560 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                565                 570                 575     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            580                 585                 590         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        595                 600                 605             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    610                 615                 620                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
625                 630                 635                 640 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                645                 650                 655     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            660                 665                 670         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        675                 680                 685             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    690                 695                 700                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
705                 710                 715                 720 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                725                 730                 735     


Leu Ser Pro Gly Lys 
            740     


<210>  65
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  65

Gly Ser Gly Ile Glu Pro Asp Ser Gly 
1               5                   


<210>  66
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  66

Val Leu Pro Ala Ser Leu Tyr Ser 
1               5               


<210>  67
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  67

Gly Ser Gly Ile Glu Pro Asp Ser Gly 
1               5                   


<210>  68
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  68

Thr Thr Gln Ser Lys Arg Lys Gly His Phe Ser Arg Cys Pro Lys Gln 
1               5                   10                  15      


Tyr Lys His Tyr Cys Ile Lys Gly Arg Cys Arg Phe Val Val Ala Glu 
            20                  25                  30          


Gln Thr Pro Ser Cys Val Cys Asp Glu Gly Tyr Ile Gly Ala Arg Cys 
        35                  40                  45              


Glu Arg Val Asp Leu Phe Tyr 
    50                  55  


<210>  69
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  69

Lys Gly Lys Gly Leu Gly Lys Lys Arg Asp Pro Cys Leu Arg Lys Tyr 
1               5                   10                  15      


Lys Asp Phe Cys Ile His Gly Glu Cys Lys Tyr Val Lys Glu Leu Arg 
            20                  25                  30          


Ala Pro Ser Cys Ile Cys His Pro Gly Tyr His Gly Glu Arg Cys His 
        35                  40                  45              


Gly Leu Ser Leu Pro Val 
    50                  


