                               SEQUENCE LISTING

<110> MORPHOSYS AG
      GALAPAGOS NV
 
<120> HIGH CONCENTRATION LIQUID ANTIBODY FORMULATIONS

<130> PAT058269-WO-PCT

<140> EP 18181380.9
<141> 2018-07-03

<160> 23    

<170> PatentIn version 3.5

<210> 1
<211> 197
<212> PRT
<213> Homo sapiens

<400> 1
Met Thr Leu Leu Pro Gly Leu Leu Phe Leu Thr Trp Leu His Thr Cys 
1               5                   10                  15      


Leu Ala His His Asp Pro Ser Leu Arg Gly His Pro His Ser His Gly 
            20                  25                  30          


Thr Pro His Cys Tyr Ser Ala Glu Glu Leu Pro Leu Gly Gln Ala Pro 
        35                  40                  45              


Pro His Leu Leu Ala Arg Gly Ala Lys Trp Gly Gln Ala Leu Pro Val 
    50                  55                  60                  


Ala Leu Val Ser Ser Leu Glu Ala Ala Ser His Arg Gly Arg His Glu 
65                  70                  75                  80  


Arg Pro Ser Ala Thr Thr Gln Cys Pro Val Leu Arg Pro Glu Glu Val 
                85                  90                  95      


Leu Glu Ala Asp Thr His Gln Arg Ser Ile Ser Pro Trp Arg Tyr Arg 
            100                 105                 110         


Val Asp Thr Asp Glu Asp Arg Tyr Pro Gln Lys Leu Ala Phe Ala Glu 
        115                 120                 125             


Cys Leu Cys Arg Gly Cys Ile Asp Ala Arg Thr Gly Arg Glu Thr Ala 
    130                 135                 140                 


Ala Leu Asn Ser Val Arg Leu Leu Gln Ser Leu Leu Val Leu Arg Arg 
145                 150                 155                 160 


Arg Pro Cys Ser Arg Asp Gly Ser Gly Leu Pro Thr Pro Gly Ala Phe 
                165                 170                 175     


Ala Phe His Thr Glu Phe Ile His Val Pro Val Gly Cys Thr Cys Val 
            180                 185                 190         


Leu Pro Arg Ser Val 
        195         


<210> 2
<211> 866
<212> PRT
<213> Homo sapiens

<400> 2
Met Gly Ala Ala Arg Ser Pro Pro Ser Ala Val Pro Gly Pro Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Leu Leu Leu Gly Val Leu Ala Pro Gly Gly Ala Ser 
            20                  25                  30          


Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys Ser Gln Pro Gly Leu 
        35                  40                  45              


Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His 
    50                  55                  60                  


Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu 
65                  70                  75                  80  


His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile 
                85                  90                  95      


Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala 
            100                 105                 110         


Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg 
        115                 120                 125             


Phe Glu Phe Leu Ser Lys Leu Arg His His His Arg Arg Trp Arg Phe 
    130                 135                 140                 


Thr Phe Ser His Phe Val Val Asp Pro Asp Gln Glu Tyr Glu Val Thr 
145                 150                 155                 160 


Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln 
                165                 170                 175     


Ser Lys Asn Phe Leu Val Pro Asp Cys Glu His Ala Arg Met Lys Val 
            180                 185                 190         


Thr Thr Pro Cys Met Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile Thr 
        195                 200                 205             


Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser Phe Thr Leu Trp 
    210                 215                 220                 


Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser Phe Pro His Met 
225                 230                 235                 240 


Glu Asn His Ser Cys Phe Glu His Met His His Ile Pro Ala Pro Arg 
                245                 250                 255     


Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu Thr Leu Arg Asn 
            260                 265                 270         


Leu Lys Gly Cys Cys Arg His Gln Val Gln Ile Gln Pro Phe Phe Ser 
        275                 280                 285             


Ser Cys Leu Asn Asp Cys Leu Arg His Ser Ala Thr Val Ser Cys Pro 
    290                 295                 300                 


Glu Met Pro Asp Thr Pro Glu Pro Ile Pro Asp Tyr Met Pro Leu Trp 
305                 310                 315                 320 


Val Tyr Trp Phe Ile Thr Gly Ile Ser Ile Leu Leu Val Gly Ser Val 
                325                 330                 335     


Ile Leu Leu Ile Val Cys Met Thr Trp Arg Leu Ala Gly Pro Gly Ser 
            340                 345                 350         


Glu Lys Tyr Ser Asp Asp Thr Lys Tyr Thr Asp Gly Leu Pro Ala Ala 
        355                 360                 365             


Asp Leu Ile Pro Pro Pro Leu Lys Pro Arg Lys Val Trp Ile Ile Tyr 
    370                 375                 380                 


Ser Ala Asp His Pro Leu Tyr Val Asp Val Val Leu Lys Phe Ala Gln 
385                 390                 395                 400 


Phe Leu Leu Thr Ala Cys Gly Thr Glu Val Ala Leu Asp Leu Leu Glu 
                405                 410                 415     


Glu Gln Ala Ile Ser Glu Ala Gly Val Met Thr Trp Val Gly Arg Gln 
            420                 425                 430         


Lys Gln Glu Met Val Glu Ser Asn Ser Lys Ile Ile Val Leu Cys Ser 
        435                 440                 445             


Arg Gly Thr Arg Ala Lys Trp Gln Ala Leu Leu Gly Arg Gly Ala Pro 
    450                 455                 460                 


Val Arg Leu Arg Cys Asp His Gly Lys Pro Val Gly Asp Leu Phe Thr 
465                 470                 475                 480 


Ala Ala Met Asn Met Ile Leu Pro Asp Phe Lys Arg Pro Ala Cys Phe 
                485                 490                 495     


Gly Thr Tyr Val Val Cys Tyr Phe Ser Glu Val Ser Cys Asp Gly Asp 
            500                 505                 510         


Val Pro Asp Leu Phe Gly Ala Ala Pro Arg Tyr Pro Leu Met Asp Arg 
        515                 520                 525             


Phe Glu Glu Val Tyr Phe Arg Ile Gln Asp Leu Glu Met Phe Gln Pro 
    530                 535                 540                 


Gly Arg Met His Arg Val Gly Glu Leu Ser Gly Asp Asn Tyr Leu Arg 
545                 550                 555                 560 


Ser Pro Gly Gly Arg Gln Leu Arg Ala Ala Leu Asp Arg Phe Arg Asp 
                565                 570                 575     


Trp Gln Val Arg Cys Pro Asp Trp Phe Glu Cys Glu Asn Leu Tyr Ser 
            580                 585                 590         


Ala Asp Asp Gln Asp Ala Pro Ser Leu Asp Glu Glu Val Phe Glu Glu 
        595                 600                 605             


Pro Leu Leu Pro Pro Gly Thr Gly Ile Val Lys Arg Ala Pro Leu Val 
    610                 615                 620                 


Arg Glu Pro Gly Ser Gln Ala Cys Leu Ala Ile Asp Pro Leu Val Gly 
625                 630                 635                 640 


Glu Glu Gly Gly Ala Ala Val Ala Lys Leu Glu Pro His Leu Gln Pro 
                645                 650                 655     


Arg Gly Gln Pro Ala Pro Gln Pro Leu His Thr Leu Val Leu Ala Ala 
            660                 665                 670         


Glu Glu Gly Ala Leu Val Ala Ala Val Glu Pro Gly Pro Leu Ala Asp 
        675                 680                 685             


Gly Ala Ala Val Arg Leu Ala Leu Ala Gly Glu Gly Glu Ala Cys Pro 
    690                 695                 700                 


Leu Leu Gly Ser Pro Gly Ala Gly Arg Asn Ser Val Leu Phe Leu Pro 
705                 710                 715                 720 


Val Asp Pro Glu Asp Ser Pro Leu Gly Ser Ser Thr Pro Met Ala Ser 
                725                 730                 735     


Pro Asp Leu Leu Pro Glu Asp Val Arg Glu His Leu Glu Gly Leu Met 
            740                 745                 750         


Leu Ser Leu Phe Glu Gln Ser Leu Ser Cys Gln Ala Gln Gly Gly Cys 
        755                 760                 765             


Ser Arg Pro Ala Met Val Leu Thr Asp Pro His Thr Pro Tyr Glu Glu 
    770                 775                 780                 


Glu Gln Arg Gln Ser Val Gln Ser Asp Gln Gly Tyr Ile Ser Arg Ser 
785                 790                 795                 800 


Ser Pro Gln Pro Pro Glu Gly Leu Thr Glu Met Glu Glu Glu Glu Glu 
                805                 810                 815     


Glu Glu Gln Asp Pro Gly Lys Pro Ala Leu Pro Leu Ser Pro Glu Asp 
            820                 825                 830         


Leu Glu Ser Leu Arg Ser Leu Gln Arg Gln Leu Leu Phe Arg Gln Leu 
        835                 840                 845             


Gln Lys Asn Ser Gly Trp Asp Thr Met Gly Ser Glu Ser Glu Gly Pro 
    850                 855                 860                 


Ser Ala 
865     


<210> 3
<211> 667
<212> PRT
<213> Homo sapiens

<400> 3
Met Gly Ser Ser Arg Leu Ala Ala Leu Leu Leu Pro Leu Leu Leu Ile 
1               5                   10                  15      


Val Ile Asp Leu Ser Asp Ser Ala Gly Ile Gly Phe Arg His Leu Pro 
            20                  25                  30          


His Trp Asn Thr Arg Cys Pro Leu Ala Ser His Thr Asp Asp Ser Phe 
        35                  40                  45              


Thr Gly Ser Ser Ala Tyr Ile Pro Cys Arg Thr Trp Trp Ala Leu Phe 
    50                  55                  60                  


Ser Thr Lys Pro Trp Cys Val Arg Val Trp His Cys Ser Arg Cys Leu 
65                  70                  75                  80  


Cys Gln His Leu Leu Ser Gly Gly Ser Gly Leu Gln Arg Gly Leu Phe 
                85                  90                  95      


His Leu Leu Val Gln Lys Ser Lys Lys Ser Ser Thr Phe Lys Phe Tyr 
            100                 105                 110         


Arg Arg His Lys Met Pro Ala Pro Ala Gln Arg Lys Leu Leu Pro Arg 
        115                 120                 125             


Arg His Leu Ser Glu Lys Ser His His Ile Ser Ile Pro Ser Pro Asp 
    130                 135                 140                 


Ile Ser His Lys Gly Leu Arg Ser Lys Arg Thr Gln Pro Ser Asp Pro 
145                 150                 155                 160 


Glu Thr Trp Glu Ser Leu Pro Arg Leu Asp Ser Gln Arg His Gly Gly 
                165                 170                 175     


Pro Glu Phe Ser Phe Asp Leu Leu Pro Glu Ala Arg Ala Ile Arg Val 
            180                 185                 190         


Thr Ile Ser Ser Gly Pro Glu Val Ser Val Arg Leu Cys His Gln Trp 
        195                 200                 205             


Ala Leu Glu Cys Glu Glu Leu Ser Ser Pro Tyr Asp Val Gln Lys Ile 
    210                 215                 220                 


Val Ser Gly Gly His Thr Val Glu Leu Pro Tyr Glu Phe Leu Leu Pro 
225                 230                 235                 240 


Cys Leu Cys Ile Glu Ala Ser Tyr Leu Gln Glu Asp Thr Val Arg Arg 
                245                 250                 255     


Lys Lys Cys Pro Phe Gln Ser Trp Pro Glu Ala Tyr Gly Ser Asp Phe 
            260                 265                 270         


Trp Lys Ser Val His Phe Thr Asp Tyr Ser Gln His Thr Gln Met Val 
        275                 280                 285             


Met Ala Leu Thr Leu Arg Cys Pro Leu Lys Leu Glu Ala Ala Leu Cys 
    290                 295                 300                 


Gln Arg His Asp Trp His Thr Leu Cys Lys Asp Leu Pro Asn Ala Thr 
305                 310                 315                 320 


Ala Arg Glu Ser Asp Gly Trp Tyr Val Leu Glu Lys Val Asp Leu His 
                325                 330                 335     


Pro Gln Leu Cys Phe Lys Phe Ser Phe Gly Asn Ser Ser His Val Glu 
            340                 345                 350         


Cys Pro His Gln Thr Gly Ser Leu Thr Ser Trp Asn Val Ser Met Asp 
        355                 360                 365             


Thr Gln Ala Gln Gln Leu Ile Leu His Phe Ser Ser Arg Met His Ala 
    370                 375                 380                 


Thr Phe Ser Ala Ala Trp Ser Leu Pro Gly Leu Gly Gln Asp Thr Leu 
385                 390                 395                 400 


Val Pro Pro Val Tyr Thr Val Ser Gln Ala Arg Gly Ser Ser Pro Val 
                405                 410                 415     


Ser Leu Asp Leu Ile Ile Pro Phe Leu Arg Pro Gly Cys Cys Val Leu 
            420                 425                 430         


Val Trp Arg Ser Asp Val Gln Phe Ala Trp Lys His Leu Leu Cys Pro 
        435                 440                 445             


Asp Val Ser Tyr Arg His Leu Gly Leu Leu Ile Leu Ala Leu Leu Ala 
    450                 455                 460                 


Leu Leu Thr Leu Leu Gly Val Val Leu Ala Leu Thr Cys Arg Arg Pro 
465                 470                 475                 480 


Gln Ser Gly Pro Gly Pro Ala Arg Pro Val Leu Leu Leu His Ala Ala 
                485                 490                 495     


Asp Ser Glu Ala Gln Arg Arg Leu Val Gly Ala Leu Ala Glu Leu Leu 
            500                 505                 510         


Arg Ala Ala Leu Gly Gly Gly Arg Asp Val Ile Val Asp Leu Trp Glu 
        515                 520                 525             


Gly Arg His Val Ala Arg Val Gly Pro Leu Pro Trp Leu Trp Ala Ala 
    530                 535                 540                 


Arg Thr Arg Val Ala Arg Glu Gln Gly Thr Val Leu Leu Leu Trp Ser 
545                 550                 555                 560 


Gly Ala Asp Leu Arg Pro Val Ser Gly Pro Asp Pro Arg Ala Ala Pro 
                565                 570                 575     


Leu Leu Ala Leu Leu His Ala Ala Pro Arg Pro Leu Leu Leu Leu Ala 
            580                 585                 590         


Tyr Phe Ser Arg Leu Cys Ala Lys Gly Asp Ile Pro Pro Pro Leu Arg 
        595                 600                 605             


Ala Leu Pro Arg Tyr Arg Leu Leu Arg Asp Leu Pro Arg Leu Leu Arg 
    610                 615                 620                 


Ala Leu Asp Ala Arg Pro Phe Ala Glu Ala Thr Ser Trp Gly Arg Leu 
625                 630                 635                 640 


Gly Ala Arg Gln Arg Arg Gln Ser Arg Leu Glu Leu Cys Ser Arg Leu 
                645                 650                 655     


Glu Arg Glu Ala Ala Arg Leu Ala Asp Leu Gly 
            660                 665         


<210> 4
<211> 194
<212> PRT
<213> Mus musculus

<400> 4
Met Ser Leu Leu Leu Leu Gly Trp Leu Pro Thr Gly Met Thr His Gln 
1               5                   10                  15      


Asp Pro Pro Ser Trp Gly Lys Pro Arg Ser His Arg Thr Leu Arg Cys 
            20                  25                  30          


Tyr Ser Ala Glu Glu Leu Ser His Gly Gln Ala Pro Pro His Leu Leu 
        35                  40                  45              


Thr Arg Ser Ala Arg Trp Glu Gln Ala Leu Pro Val Ala Leu Val Ala 
    50                  55                  60                  


Ser Leu Glu Ala Thr Gly His Arg Arg Gln His Glu Gly Pro Leu Ala 
65                  70                  75                  80  


Gly Thr Gln Cys Pro Val Leu Arg Pro Glu Glu Val Leu Glu Ala Asp 
                85                  90                  95      


Thr His Glu Arg Ser Ile Ser Pro Trp Arg Tyr Arg Ile Asp Thr Asp 
            100                 105                 110         


Glu Asn Arg Tyr Pro Gln Lys Leu Ala Val Ala Glu Cys Leu Cys Arg 
        115                 120                 125             


Gly Cys Ile Asn Ala Lys Thr Gly Arg Glu Thr Ala Ala Leu Asn Ser 
    130                 135                 140                 


Val Gln Leu Leu Gln Ser Leu Leu Val Leu Arg Arg Gln Pro Cys Ser 
145                 150                 155                 160 


Arg Asp Gly Thr Ala Asp Pro Thr Pro Gly Ser Phe Ala Phe His Thr 
                165                 170                 175     


Glu Phe Ile Arg Val Pro Val Gly Cys Thr Cys Val Leu Pro Arg Ser 
            180                 185                 190         


Thr Gln 
        


<210> 5
<211> 197
<212> PRT
<213> Macaca fascicularis

<400> 5
Met Thr Leu Leu Pro Gly Leu Leu Phe Leu Thr Trp Leu His Ala Cys 
1               5                   10                  15      


Leu Ala His Gln Asp Pro Phe Leu Arg Gly His Pro His Thr His Gly 
            20                  25                  30          


Thr Pro Arg Cys Tyr Ser Ala Glu Glu Leu Pro Leu Gly Gln Ala Pro 
        35                  40                  45              


Pro His Leu Leu Ala Arg Gly Ala Lys Trp Gly Gln Ala Leu Pro Val 
    50                  55                  60                  


Ala Leu Val Ser Ser Leu Glu Ala Ala Gly His Arg Arg Arg His Asp 
65                  70                  75                  80  


Arg Pro Ser Ala Ala Thr Gln Cys Pro Val Leu Arg Pro Glu Glu Val 
                85                  90                  95      


Leu Glu Ala Asp Thr His Gln Arg Ser Ile Ser Pro Trp Arg Tyr Arg 
            100                 105                 110         


Val Asp Thr Asp Glu Asp Arg Tyr Pro Gln Lys Leu Ala Phe Ala Glu 
        115                 120                 125             


Cys Leu Cys Arg Gly Cys Ile Asp Pro Arg Thr Gly Arg Glu Thr Ala 
    130                 135                 140                 


Ala Leu Asn Ser Val Arg Leu Leu Gln Ser Leu Leu Val Leu Arg Arg 
145                 150                 155                 160 


Arg Pro Cys Ser Arg Asp Gly Ser Gly Leu Pro Thr Pro Gly Ala Phe 
                165                 170                 175     


Ala Phe His Thr Glu Phe Ile Arg Val Pro Val Gly Cys Thr Cys Val 
            180                 185                 190         


Leu Pro Arg Ser Val 
        195         


<210> 6
<211> 637
<212> PRT
<213> Mus musculus

<400> 6
Met Gly Ser Pro Arg Leu Ala Ala Leu Leu Leu Ser Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ile Gly Leu Ala Val Ser Ala Arg Val Ala Cys Pro Cys Leu Arg 
            20                  25                  30          


Ser Trp Thr Ser His Cys Leu Leu Ala Tyr Arg Val Asp Lys Arg Phe 
        35                  40                  45              


Ala Gly Leu Gln Trp Gly Trp Phe Pro Leu Leu Val Arg Lys Ser Lys 
    50                  55                  60                  


Ser Pro Pro Lys Phe Glu Asp Tyr Trp Arg His Arg Thr Pro Ala Ser 
65                  70                  75                  80  


Phe Gln Arg Lys Leu Leu Gly Ser Pro Ser Leu Ser Glu Glu Ser His 
                85                  90                  95      


Arg Ile Ser Ile Pro Ser Ser Ala Ile Ser His Arg Gly Gln Arg Thr 
            100                 105                 110         


Lys Arg Ala Gln Pro Ser Ala Ala Glu Gly Arg Glu His Leu Pro Glu 
        115                 120                 125             


Ala Gly Ser Gln Lys Cys Gly Gly Pro Glu Phe Ser Phe Asp Leu Leu 
    130                 135                 140                 


Pro Glu Val Gln Ala Val Arg Val Thr Ile Pro Ala Gly Pro Lys Ala 
145                 150                 155                 160 


Ser Val Arg Leu Cys Tyr Gln Trp Ala Leu Glu Cys Glu Asp Leu Ser 
                165                 170                 175     


Ser Pro Phe Asp Thr Gln Lys Ile Val Ser Gly Gly His Thr Val Asp 
            180                 185                 190         


Leu Pro Tyr Glu Phe Leu Leu Pro Cys Met Cys Ile Glu Ala Ser Tyr 
        195                 200                 205             


Leu Gln Glu Asp Thr Val Arg Arg Lys Lys Cys Pro Phe Gln Ser Trp 
    210                 215                 220                 


Pro Glu Ala Tyr Gly Ser Asp Phe Trp Gln Ser Ile Arg Phe Thr Asp 
225                 230                 235                 240 


Tyr Ser Gln His Asn Gln Met Val Met Ala Leu Thr Leu Arg Cys Pro 
                245                 250                 255     


Leu Lys Leu Glu Ala Ser Leu Cys Trp Arg Gln Asp Pro Leu Thr Pro 
            260                 265                 270         


Cys Glu Thr Leu Pro Asn Ala Thr Ala Gln Glu Ser Glu Gly Trp Tyr 
        275                 280                 285             


Ile Leu Glu Asn Val Asp Leu His Pro Gln Leu Cys Phe Lys Phe Ser 
    290                 295                 300                 


Phe Glu Asn Ser Ser His Val Glu Cys Pro His Gln Ser Gly Ser Leu 
305                 310                 315                 320 


Pro Ser Trp Thr Val Ser Met Asp Thr Gln Ala Gln Gln Leu Thr Leu 
                325                 330                 335     


His Phe Ser Ser Arg Thr Tyr Ala Thr Phe Ser Ala Ala Trp Ser Asp 
            340                 345                 350         


Pro Gly Leu Gly Pro Asp Thr Pro Met Pro Pro Val Tyr Ser Ile Ser 
        355                 360                 365             


Gln Thr Gln Gly Ser Val Pro Val Thr Leu Asp Leu Ile Ile Pro Phe 
    370                 375                 380                 


Leu Arg Gln Glu Asn Cys Ile Leu Val Trp Arg Ser Asp Val His Phe 
385                 390                 395                 400 


Ala Trp Lys His Val Leu Cys Pro Asp Val Ser His Arg His Leu Gly 
                405                 410                 415     


Leu Leu Ile Leu Ala Leu Leu Ala Leu Thr Ala Leu Val Gly Val Val 
            420                 425                 430         


Leu Val Leu Leu Gly Arg Arg Leu Leu Pro Gly Ser Gly Arg Thr Arg 
        435                 440                 445             


Pro Val Leu Leu Leu His Ala Ala Asp Ser Glu Ala Gln Arg Arg Leu 
    450                 455                 460                 


Val Gly Ala Leu Ala Glu Leu Leu Arg Thr Ala Leu Gly Gly Gly Arg 
465                 470                 475                 480 


Asp Val Ile Val Asp Leu Trp Glu Gly Thr His Val Ala Arg Ile Gly 
                485                 490                 495     


Pro Leu Pro Trp Leu Trp Ala Ala Arg Glu Arg Val Ala Arg Glu Gln 
            500                 505                 510         


Gly Thr Val Leu Leu Leu Trp Asn Cys Ala Gly Pro Ser Thr Ala Cys 
        515                 520                 525             


Ser Gly Asp Pro Gln Ala Ala Ser Leu Arg Thr Leu Leu Cys Ala Ala 
    530                 535                 540                 


Pro Arg Pro Leu Leu Leu Ala Tyr Phe Ser Arg Leu Cys Ala Lys Gly 
545                 550                 555                 560 


Asp Ile Pro Arg Pro Leu Arg Ala Leu Pro Arg Tyr Arg Leu Leu Arg 
                565                 570                 575     


Asp Leu Pro Arg Leu Leu Arg Ala Leu Asp Ala Gln Pro Ala Thr Leu 
            580                 585                 590         


Ala Ser Ser Trp Ser His Leu Gly Ala Lys Arg Cys Leu Lys Asn Arg 
        595                 600                 605             


Leu Glu Gln Cys His Leu Leu Glu Leu Glu Ala Ala Lys Asp Asp Tyr 
    610                 615                 620                 


Gln Gly Ser Thr Asn Ser Pro Cys Gly Phe Ser Cys Leu 
625                 630                 635         


<210> 7
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 7
Asp Tyr Ala Met His 
1               5   


<210> 8
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 8
Tyr Ile Gly Gly Val Gly Glu Gly Thr Gln Tyr Ala Glu Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 9
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 9
Gly Phe Ala Ile Arg Tyr Tyr Gly Phe Asp Tyr 
1               5                   10      


<210> 10
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 10
Gly Phe Thr Val Ser Asp Tyr 
1               5           


<210> 11
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 11
Gly Gly Val Gly Glu Gly 
1               5       


<210> 12
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 12
Gly Phe Ala Ile Arg Tyr Tyr Gly Phe Asp Tyr 
1               5                   10      


<210> 13
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 13
Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala Tyr 
1               5                   10      


<210> 14
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 14
Gln Asp Ser Lys Arg Pro Ser 
1               5           


<210> 15
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 15
Gln Val Phe Thr Phe Pro Leu Val Thr Thr 
1               5                   10  


<210> 16
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 16
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Gly Gly Val Gly Glu Gly Thr Gln Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Phe Ala Ile Arg Tyr Tyr Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210> 17
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 17
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Phe Thr Phe Pro Leu Val Thr 
                85                  90                  95      


Thr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110 


<210> 18
<211> 450
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 18
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Gly Gly Val Gly Glu Gly Thr Gln Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Phe Ala Ile Arg Tyr Tyr Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210> 19
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 19
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Phe Thr Phe Pro Leu Val Thr 
                85                  90                  95      


Thr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210> 20
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 20
tcctacgagc tgacccagcc cccctccgtg tccgtgtctc ctggccagac cgcctccatc       60

acctgttccg gcgacaagct gggcgataag tacgcctact ggtatcagca gaagcccggc      120

cagtcccccg tgctggtcat ctaccaggac tccaagcggc cctccggcat ccctgagcgg      180

ttctccggct ccaactccgg caacaccgcc accctgacca tctccggcac ccaggccgag      240

gacgaggccg actactactg ccaggtgttc accttccccc tggtcaccac cgtgttcggc      300

ggaggcacca agctgaccgt gctgggccag                                       330


<210> 21
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 21
gaggtgcagc tgctggaatc cggcggagga ctggtgcagc ctggcggctc cctgagactg       60

tcttgcgccg cctccggctt caccgtgtcc gactacgcta tgcactgggt ccgacaggcc      120

cctggcaagg gcctggaatg ggtgtcctat atcggcggcg tgggcgaggg cacccagtac      180

gctgagtctg tgaagggccg gttcaccatc tcccgggaca actccaagaa caccctgtac      240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgtgc cagaggcttc      300

gccatccggt actacggctt cgactactgg ggccagggca ccctggtcac cgtgtctagc      360


<210> 22
<211> 642
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 22
tcctacgagc tgacccagcc cccctccgtg tccgtgtctc ctggccagac cgcctccatc       60

acctgttccg gcgacaagct gggcgataag tacgcctact ggtatcagca gaagcccggc      120

cagtcccccg tgctggtcat ctaccaggac tccaagcggc cctccggcat ccctgagcgg      180

ttctccggct ccaactccgg caacaccgcc accctgacca tctccggcac ccaggccgag      240

gacgaggccg actactactg ccaggtgttc accttccccc tggtcaccac cgtgttcggc      300

ggaggcacca agctgaccgt gctgggccag cctaaggccg ctccctccgt gaccctgttc      360

cccccatcct ccgaggaact gcaggccaac aaggccaccc tggtctgcct gatctccgac      420

ttctaccctg gcgccgtgac cgtggcctgg aaggccgaca gctctcctgt gaaggccggc      480

gtggaaacca ccaccccctc caagcagtcc aacaacaaat acgccgcctc ctcctacctg      540

tccctgaccc ccgagcagtg gaagtcccac cggtcctaca gctgccaggt cacacacgag      600

ggctccaccg tggaaaagac cgtggcccct accgagtgct cc                         642


<210> 23
<211> 1350
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 23
gaggtgcagc tgctggaatc cggcggagga ctggtgcagc ctggcggctc cctgagactg       60

tcttgcgccg cctccggctt caccgtgtcc gactacgcta tgcactgggt ccgacaggcc      120

cctggcaagg gcctggaatg ggtgtcctat atcggcggcg tgggcgaggg cacccagtac      180

gctgagtctg tgaagggccg gttcaccatc tcccgggaca actccaagaa caccctgtac      240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgtgc cagaggcttc      300

gccatccggt actacggctt cgactactgg ggccagggca ccctggtcac cgtgtctagc      360

gcctccacca agggcccctc cgtgttccct ctggccccct ccagcaagtc cacctctggc      420

ggcaccgctg ccctgggctg cctggtcaag gactacttcc ccgagcccgt gaccgtgtcc      480

tggaactctg gcgccctgac ctccggcgtg cacaccttcc ctgccgtgct gcagtcctcc      540

ggcctgtact ccctgtcctc cgtcgtgacc gtgccctcca gctctctggg cacccagacc      600

tacatctgca acgtgaacca caagccctcc aacaccaagg tggacaagcg ggtggaaccc      660

aagtcctgcg acaagaccca cacctgtccc ccctgccctg cccctgaact gctgggcgga      720

ccttccgtgt tcctgttccc cccaaagccc aaggacaccc tgatgatctc ccggaccccc      780

gaagtgacct gcgtggtggt ggacgtgtcc cacgaggacc ctgaagtgaa gttcaattgg      840

tacgtggacg gcgtggaagt gcacaacgcc aagaccaagc ccagagagga acagtacaac      900

tccacctacc gggtggtgtc cgtgctgacc gtgctgcacc aggactggct gaacggcaaa      960

gagtacaagt gcaaggtgtc caacaaggcc ctgcctgccc ccatcgaaaa gaccatctcc     1020

aaggccaagg gccagccccg cgagccccag gtgtacacac tgccccctag ccgggaagag     1080

atgaccaaga accaggtgtc cctgacctgt ctggtcaagg gcttctaccc ctccgacatt     1140

gccgtggaat gggagtccaa cggccagccc gagaacaact acaagaccac cccccctgtg     1200

ctggactccg acggctcatt cttcctgtac tccaagctga ccgtggacaa gtcccggtgg     1260

cagcagggca acgtgttctc ctgctccgtg atgcacgagg ccctgcacaa ccactacacc     1320

cagaagtccc tgtccctgag ccccggcaag                                      1350


