                         SEQUENCE LISTING

<110>  3-D Matrix, Ltd.
 
<120>  Ionic Self-Assembling Peptides

<130>  F519PCT205

<150>  US 62/693,877
<151>  2018-07-03

<160>  99    

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Self-assembling peptides

<400>  1

Lys Leu Asn Leu Lys Leu Asn Leu Lys Leu Asn Leu 
1               5                   10          


<210>  2
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Self-assembling peptides

<400>  2

Leu Asn Leu Lys Leu Asn Leu Lys Leu Asn Leu Lys 
1               5                   10          


<210>  3
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Self-assembling peptides

<400>  3

Asn Leu Lys Leu Asn Leu Lys Leu Asn Leu Lys Leu 
1               5                   10          


<210>  4
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Self-assembling peptides

<400>  4

Leu Lys Leu Asn Leu Lys Leu Asn Leu Lys Leu Asn 
1               5                   10          


<210>  5
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Self-assembling peptides

<400>  5

Lys Leu Asn Leu Lys Leu Asn Leu Lys Leu Asn Leu Lys 
1               5                   10              


<210>  6
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Self-assembling peptides

<400>  6

Lys Leu Asn Leu Lys Leu Asn Leu Lys Leu Asn Leu Lys Leu Asn Leu 
1               5                   10                  15      


Lys 
    


<210>  7
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Self-assembling peptides

<400>  7

Ile Gln Ile Lys Ile Gln Ile Lys Ile Gln Ile Lys 
1               5                   10          


<210>  8
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Self-assembling peptides

<400>  8

Ile Gln Ile Lys Ile Gln Ile Lys Ile Gln Ile Lys Ile 
1               5                   10              


<210>  9
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Self-assembling peptides

<400>  9

Lys Ile Gln Ile Lys Ile Gln Ile Lys Ile Gln Ile Lys 
1               5                   10              


<210>  10
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Self-assembling peptides

<400>  10

Gln Ile Lys Ile Gln Ile Lys Ile Gln Ile Lys Ile Gln 
1               5                   10              


<210>  11
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Self-assembling peptides

<400>  11

Ile Lys Ile Gln Ile Lys Ile Gln Ile Lys Ile Gln Ile 
1               5                   10              


<210>  12
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Self-assembling peptides

<400>  12

Ile Asn Ile Lys Ile Asn Ile Lys Ile Asn Ile Lys Ile 
1               5                   10              


<210>  13
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Self-assembling peptides

<400>  13

Asn Leu Glu Leu Asn Leu Glu Leu Asn Leu Glu Leu 
1               5                   10          


<210>  14
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Self-assembling peptides

<400>  14

Asn Leu Asp Leu Asn Leu Asp Leu Asn Leu Asp Leu 
1               5                   10          


<210>  15
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Self-assembling peptides

<400>  15

Gln Leu Glu Leu Gln Leu Glu Leu Gln Leu Glu Leu 
1               5                   10          


<210>  16
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  16

Leu Glu Leu Gln Leu Glu Leu Gln Leu Glu Leu Gln 
1               5                   10          


<210>  17
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Self-assembling peptides

<400>  17

Lys Ala Asn Ala Lys Ala Asn Ala Lys Ala Asn Ala 
1               5                   10          


<210>  18
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Self-assembling peptides

<400>  18

Lys Val Asn Val Lys Val Asn Val Lys Val Asn Val 
1               5                   10          


<210>  19
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Self-assembling peptides

<400>  19

Arg Ala Asn Ala Arg Ala Asn Ala Arg Ala Asn Ala Arg Ala Asn Ala 
1               5                   10                  15      


<210>  20
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  20

Lys Leu Thr Leu Lys Leu Thr Leu Lys Leu Thr Leu 
1               5                   10          


<210>  21
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  21

Lys Leu Asn Leu Lys Leu Asn Leu Lys Leu Asn Leu 
1               5                   10          


<210>  22
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  22

Leu Asn Leu Lys Leu Asn Leu Lys Leu Asn Leu Lys 
1               5                   10          


<210>  23
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  23

Asn Leu Lys Leu Asn Leu Lys Leu Asn Leu Lys Leu 
1               5                   10          


<210>  24
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  24

Leu Lys Leu Asn Leu Lys Leu Asn Leu Lys Leu Asn 
1               5                   10          


<210>  25
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  25

Lys Leu Asn Leu Lys Leu Asn Leu Lys Leu Asn Leu Lys 
1               5                   10              


<210>  26
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  26

Lys Leu Asn Leu Lys Leu Asn Leu Lys Leu Asn Leu Lys Leu Asn Leu 
1               5                   10                  15      


Lys 
    


<210>  27
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  27

Ile Gln Ile Lys Ile Gln Ile Lys Ile Gln Ile Lys 
1               5                   10          


<210>  28
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  28

Ile Gln Ile Lys Ile Gln Ile Lys Ile Gln Ile Lys Ile 
1               5                   10              


<210>  29
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  29

Lys Ile Gln Ile Lys Ile Gln Ile Lys Ile Gln Ile Lys 
1               5                   10              


<210>  30
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  30

Gln Ile Lys Ile Gln Ile Lys Ile Gln Ile Lys Ile Gln 
1               5                   10              


<210>  31
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  31

Ile Lys Ile Gln Ile Lys Ile Gln Ile Lys Ile Gln Ile 
1               5                   10              


<210>  32
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  32

Ile Asn Ile Lys Ile Asn Ile Lys Ile Asn Ile Lys Ile 
1               5                   10              


<210>  33
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  33

Asn Leu Glu Leu Asn Leu Glu Leu Asn Leu Glu Leu 
1               5                   10          


<210>  34
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  34

Asn Leu Asp Leu Asn Leu Asp Leu Asn Leu Asp Leu 
1               5                   10          


<210>  35
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  35

Gln Leu Glu Leu Gln Leu Glu Leu Gln Leu Glu Leu 
1               5                   10          


<210>  36
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  36

Leu Glu Leu Gln Leu Glu Leu Gln Leu Glu Leu Gln 
1               5                   10          


<210>  37
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  37

Lys Ala Asn Ala Lys Ala Asn Ala Lys Ala Asn Ala 
1               5                   10          


<210>  38
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  38

Lys Val Asn Val Lys Val Asn Val Lys Val Asn Val 
1               5                   10          


<210>  39
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  39

Arg Ala Asn Ala Arg Ala Asn Ala Arg Ala Asn Ala Arg Ala Asn Ala 
1               5                   10                  15      


<210>  40
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  40

Lys Leu Thr Leu Lys Leu Thr Leu Lys Leu Thr Leu 
1               5                   10          


<210>  41
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Laminin-1

<400>  41

Ala Ala Ser Ile Lys Val Ala Val Ser Ala Asp Arg 
1               5                   10          


<210>  42
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Laminin-1

<400>  42

Cys Ser Arg Ala Arg Lys Gln Ala Ala Ser Ile Lys Val Ala Val Ser 
1               5                   10                  15      


Ala Asp Arg 
            


<210>  43
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Laminin-1

<400>  43

Tyr Ile Gly Ser Arg 
1               5   


<210>  44
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Laminin-1

<400>  44

Pro Asp Gly Ser Arg 
1               5   


<210>  45
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Laminin-1

<400>  45

Arg Tyr Val Val Leu Pro Arg 
1               5           


<210>  46
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Laminin-1

<400>  46

Lys Ala Phe Asp Ile Thr Tyr Val Arg Leu Lys Phe 
1               5                   10          


<210>  47
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Collagen IV

<400>  47

Thr Ala Gly Ser Cys Leu Arg Lys Phe Ser Thr Met 
1               5                   10          


<210>  48
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Laminin-1

<400>  48

Arg Asn Ile Ala Glu Ile Ile Lys Asp Ile 
1               5                   10  


<210>  49
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Laminin-1

<400>  49

Tyr Val Arg Leu 
1               


<210>  50
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Laminin-1

<400>  50

Ile Arg Val Thr Leu Asn 
1               5       


<210>  51
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Laminin-1

<400>  51

Thr Thr Val Lys Tyr Ile Phe Arg 
1               5               


<210>  52
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Laminin-1

<400>  52

Ser Ile Lys Ile Arg Gly Thr Tyr 
1               5               


<210>  53
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Laminin-1

<400>  53

Arg Gln Val Phe Gln Val Ala Tyr Ile Ile Ile Lys Ala 
1               5                   10              


<210>  54
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Laminin-1

<400>  54

Phe Gln Ile Ala Tyr Val Ile Val Lys Ala 
1               5                   10  


<210>  55
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Laminin-1

<400>  55

Gly Gln Leu Phe His Val Ala Tyr Ile Ile Ile Lys Ala 
1               5                   10              


<210>  56
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Laminin-1

<400>  56

Phe His Val Ala Tyr Val Leu Ile Lys Ala 
1               5                   10  


<210>  57
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Laminin-1

<400>  57

Leu Glu Asn Gly Glu Ile Val Ser Leu Val Asn Gly Arg 
1               5                   10              


<210>  58
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Fibronectin

<400>  58

Leu Gly Thr Ile Pro Gly 
1               5       


<210>  59
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Fibronectin

<400>  59

Asp Gly Glu Ala 
1               


<210>  60
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Fibronectin

<400>  60

Arg Glu Asp Val 
1               


<210>  61
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Elastin

<400>  61

Gly Val Gly Val Pro 
1               5   


<210>  62
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Elastin

<400>  62

Gly Val Gly Val Ala Pro 
1               5       


<210>  63
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Laminin-1

<400>  63

Ile Lys Val Ala Val 
1               5   


<210>  64
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Bone marrow homing peptide 2

<400>  64

Pro Phe Ser Ser Thr Lys Thr 
1               5           


<210>  65
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Bone marrow homing peptide 1

<400>  65

Ser Lys Pro Pro Gly Thr Ser Ser 
1               5               


<210>  66
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Laminin-1

<400>  66

Ser Asp Pro Gly Tyr Ile Gly Ser Arg 
1               5                   


<210>  67
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Laminin-1

<400>  67

Arg Asn Ile Ala Glu Leu Leu Lys Asp Ile 
1               5                   10  


<210>  68
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Collagen IV

<400>  68

Pro Arg Gly Asp Ser Gly Tyr Arg Gly Asp Ser Gly 
1               5                   10          


<210>  69
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Myelopeptide

<400>  69

Gly Phe Leu Gly Phe Pro Thr 
1               5           


<210>  70
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Laminin-l

<400>  70

Tyr Gly Pro Asp Ser Gly Arg 
1               5           


<210>  71
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  71

Lys Leu Asn Leu Lys Leu Asn Leu Lys Leu Asn Leu Gly Tyr Ile Gly 
1               5                   10                  15      


Ser Arg 
        


<210>  72
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  72

Lys Leu Asn Leu Lys Leu Asn Leu Lys Leu Asn Leu Gly Pro Asp Gly 
1               5                   10                  15      


Ser Arg 
        


<210>  73
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  73

Lys Leu Asn Leu Lys Leu Asn Leu Lys Leu Asn Leu Gly Gly Val Gly 
1               5                   10                  15      


Val Ala Pro 
            


<210>  74
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  74

Lys Leu Asn Leu Lys Leu Asn Leu Lys Leu Asn Leu Gly Pro Phe Ser 
1               5                   10                  15      


Ser Thr Lys Thr 
            20  


<210>  75
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  75

Lys Leu Asn Leu Lys Leu Asn Leu Lys Leu Asn Leu Gly Pro Arg Gly 
1               5                   10                  15      


Asp Ser Gly Tyr Arg Gly Asp Ser Gly 
            20                  25  


<210>  76
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  76

Lys Ile Gln Ile Lys Ile Gln Ile Lys Ile Gln Ile Lys Gly Tyr Ile 
1               5                   10                  15      


Gly Ser Arg 
            


<210>  77
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  77

Lys Ile Gln Ile Lys Ile Gln Ile Lys Ile Gln Ile Lys Gly Pro Asp 
1               5                   10                  15      


Gly Ser Arg 
            


<210>  78
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  78

Lys Ile Gln Ile Lys Ile Gln Ile Lys Ile Gln Ile Lys Gly Gly Val 
1               5                   10                  15      


Gly Val Ala Pro 
            20  


<210>  79
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  79

Lys Ile Gln Ile Lys Ile Gln Ile Lys Ile Gln Ile Lys Gly Pro Phe 
1               5                   10                  15      


Ser Ser Thr Lys Thr 
            20      


<210>  80
<211>  26
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  80

Lys Ile Gln Ile Lys Ile Gln Ile Lys Ile Gln Ile Lys Gly Pro Arg 
1               5                   10                  15      


Gly Asp Ser Gly Tyr Arg Gly Asp Ser Gly 
            20                  25      


<210>  81
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  81

Asn Leu Glu Leu Asn Leu Glu Leu Asn Leu Glu Leu Gly Tyr Ile Gly 
1               5                   10                  15      


Ser Arg 
        


<210>  82
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  82

Asn Leu Glu Leu Asn Leu Glu Leu Asn Leu Glu Leu Gly Pro Asp Gly 
1               5                   10                  15      


Ser Arg 
        


<210>  83
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  83

Asn Leu Glu Leu Asn Leu Glu Leu Asn Leu Glu Leu Gly Gly Val Gly 
1               5                   10                  15      


Val Ala Pro 
            


<210>  84
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  84

Asn Leu Glu Leu Asn Leu Glu Leu Asn Leu Glu Leu Gly Pro Phe Ser 
1               5                   10                  15      


Ser Thr Lys Thr 
            20  


<210>  85
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  85

Asn Leu Glu Leu Asn Leu Glu Leu Asn Leu Glu Leu Gly Pro Arg Gly 
1               5                   10                  15      


Asp Ser Gly Tyr Arg Gly Asp Ser Gly 
            20                  25  


<210>  86
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  86

Arg Ala Asn Ala Arg Ala Asn Ala Arg Ala Asn Ala Arg Ala Asn Ala 
1               5                   10                  15      


Gly Tyr Ile Gly Ser Arg 
            20          


<210>  87
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  87

Arg Ala Asn Ala Arg Ala Asn Ala Arg Ala Asn Ala Arg Ala Asn Ala 
1               5                   10                  15      


Gly Pro Asp Gly Ser Arg 
            20          


<210>  88
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  88

Arg Ala Asn Ala Arg Ala Asn Ala Arg Ala Asn Ala Arg Ala Asn Ala 
1               5                   10                  15      


Gly Gly Val Gly Val Ala Pro 
            20              


<210>  89
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  89

Arg Ala Asn Ala Arg Ala Asn Ala Arg Ala Asn Ala Arg Ala Asn Ala 
1               5                   10                  15      


Gly Pro Phe Ser Ser Thr Lys Thr 
            20                  


<210>  90
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  90

Arg Ala Asn Ala Arg Ala Asn Ala Arg Ala Asn Ala Arg Ala Asn Ala 
1               5                   10                  15      


Gly Pro Arg Gly Asp Ser Gly Tyr Arg Gly Asp Ser Gly 
            20                  25                  


<210>  91
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  91

Ile Glu Ile Lys Ile Glu Ile Lys Ile Glu Ile Lys Ile 
1               5                   10              


<210>  92
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  92

Ile Glu Ile Lys Ile Glu Ile Lys Ile Glu Ile Lys Ile 
1               5                   10              


<210>  93
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  93

Lys Leu Asp Leu Lys Leu Asp Leu Lys Leu Asp 
1               5                   10      


<210>  94
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  94

Ile Glu Ile Thr Ile Glu Ile Thr Ile Glu Ile Thr Ile 
1               5                   10              


<210>  95
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  95

Ile Thr Ile Lys Ile Thr Ile Lys Ile Thr Ile Lys Ile 
1               5                   10              


<210>  96
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  96

Lys Ile Gln Ile Lys Ile Gln Ile Lys Ile Gln Ile 
1               5                   10          


<210>  97
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  97

Ile Glu Ile Thr Ile Glu Ile Thr Ile Glu Ile Thr Ile 
1               5                   10              


<210>  98
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  98

Ile Thr Ile Lys Ile Thr Ile Lys Ile Thr Ile Lys Ile 
1               5                   10              


<210>  99
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  self-assembling peptides

<400>  99

Lys Ile Gln Ile Lys Ile Gln Ile Lys Ile Gln Ile 
1               5                   10          


