<110>    ABL Bio , Inc.

<120>    Anti-a-Synuclein antibody and use thereof

<130>    19OP30598PCT

<150>    US 62/693469
<151>    2018-07-03

<160>    41

<170>    KoPatentIn 3.0

<210>    1
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    A3F10 VH_CDRH1


<400>    1
Gly Phe Thr Phe Ser Asn Tyr Ala Met Ser
  1               5                  10


<210>    2
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    D3C6 VH_CDRH1


<400>    2
Gly Phe Thr Phe Ser Asn Tyr Ser Met Ser
  1               5                  10


<210>    3
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    4G3 VH_CDRH1


<400>    3
Gly Tyr Ser Phe Thr Gly Tyr Trp Ile Gln
  1               5                  10


<210>    4
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    5A7 VH_CDRH1


<400>    4
Gly Phe Thr Phe Asn Thr Asn Ala Met Asn
  1               5                  10


<210>    5
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    7B7 VH_CDRH1


<400>    5
Gly Phe Ile Phe Ser Asp Tyr Tyr Met Tyr
  1               5                  10


<210>    6
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    A3F10 VH_CDRH2


<400>    6
Gly Ile Ser Tyr Asp Ser Gly Ser Lys Tyr Tyr Ala Asp Ser Val Lys
  1               5                  10                  15 

Gly
   


<210>    7
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    D3C6 VH_CDRH2


<400>    7
Gly Ile Ser Pro Gly Gly Gly Ser Ile Tyr Tyr Ala Asp Ser Val Lys
  1               5                  10                  15 

Gly
   


<210>    8
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    4G3 VH_CDRH2


<400>    8
Ala Ile Tyr Pro Gly Asp Gly Asp Thr Arg
  1               5                  10


<210>    9
<211>    19
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    5A7 VH_CDRH2


<400>    9
Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser
  1               5                  10                  15 

Val Lys Asp
           


<210>    10
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    7B7 VH_CDRH2


<400>    10
Thr Ile Ser Asn Gly Gly Ser Tyr Ile Tyr Tyr Pro Asp Ser Val Lys
  1               5                  10                  15 

Gly
   


<210>    11
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    A3F10 VH_CDRH3


<400>    11
Tyr Leu Ala Thr Phe Asp Tyr
  1               5        


<210>    12
<211>    18
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    D3C6 VH_CDRH3


<400>    12
Asp Val Arg Pro Cys Thr Arg Arg Asn Cys Ser Tyr Asp Asp Gly Met
  1               5                  10                  15 

Asp Val
       


<210>    13
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    4G3 VH_CDRH3


<400>    13
Gly Asp Gly Tyr Tyr Pro Tyr
  1               5        


<210>    14
<211>    6
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    5A7 VH_CDRH3


<400>    14
His Gly Asp Phe Asp Tyr
  1               5    


<210>    15
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    7B7 VH_CDRH3


<400>    15
Glu Gly Phe Ala Tyr
  1               5


<210>    16
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    A3F10 VL_CDRL1


<400>    16
Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Thr
  1               5                  10            


<210>    17
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    D3C6 VL_CDRL1


<400>    17
Thr Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Ser
  1               5                  10            


<210>    18
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    4G3 VL_CDRL1


<400>    18
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Asn Asn Tyr Leu
  1               5                  10                  15 

Ala
   


<210>    19
<211>    16
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    5A7 VL_CDRL1


<400>    19
Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn
  1               5                  10                  15 


<210>    20
<211>    16
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    7B7 VL_CDRL1


<400>    20
Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Glu Thr Tyr Leu Asn
  1               5                  10                  15 


<210>    21
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    A3F10 VL_CDRL2


<400>    21
Ala Asp Ser Lys Arg Pro Ser
  1               5        


<210>    22
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    D3C6 VL_CDRL2


<400>    22
Ser Asp Ser Asn Arg Pro Ser
  1               5        


<210>    23
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    4G3 VL_CDRL2


<400>    23
Trp Ala Ser Thr Arg Glu Ser
  1               5        


<210>    24
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    5A7 VL_CDRL2


<400>    24
Leu Val Ser Lys Leu Asp Ser
  1               5        


<210>    25
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    7B7 VL_CDRL2


<400>    25
Leu Val Ser Lys Leu Asp Ser
  1               5        


<210>    26
<211>    11
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    A3F10 VL_CDRL3


<400>    26
Gly Thr Trp Asp Ser Ser Leu Ser Gly Tyr Val
  1               5                  10    


<210>    27
<211>    11
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    D3C6 VL_CDRL3


<400>    27
Ala Thr Trp Asp Ala Ser Leu Ser Ala Tyr Val
  1               5                  10    


<210>    28
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    4G3 VL_CDRL3


<400>    28
Trp Gln Ser Tyr Ser Leu Pro Thr
  1               5            


<210>    29
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    5A7 VL_CDRL3


<400>    29
Trp Gln Gly Thr His Phe Pro His Thr
  1               5                


<210>    30
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    7B7 VL_CDRL3


<400>    30
Trp Gln Gly Ser His Phe Pro His Thr
  1               5                


<210>    31
<211>    116
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    A3F10 heavy chain variable region


<400>    31
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
             20                  25                  30 

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Gly Ile Ser Tyr Asp Ser Gly Ser Lys Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Tyr Leu Ala Thr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110 

Thr Val Ser Ser
        115    


<210>    32
<211>    127
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    D3C6 heavy chain variable region


<400>    32
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
             20                  25                  30 

Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Gly Ile Ser Pro Gly Gly Gly Ser Ile Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Asp Val Arg Pro Cys Thr Arg Arg Asn Cys Ser Tyr Asp Asp
            100                 105                 110 

Gly Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125 




<210>    33
<211>    116
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    4G3 heavy chain variable region


<400>    33
Glu Val Gln Leu Gln Glu Ser Gly Ala Glu Leu Ala Gly Pro Gly Ala
  1               5                  10                  15 

Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr
             20                  25                  30 

Trp Ile Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Ala Ile Tyr Pro Gly Asp Gly Asp Thr Arg Tyr Thr Gln Lys Phe
     50                  55                  60 

Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
 65                  70                  75                  80 

Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Gly Asp Gly Tyr Tyr Pro Tyr Trp Gly Gln Gly Thr Thr Leu
            100                 105                 110 

Thr Val Ser Ser
        115    


<210>    34
<211>    117
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    5A7 heavy chain variable region


<400>    34
Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly
  1               5                  10                  15 

Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Asn
             20                  25                  30 

Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp
     50                  55                  60 

Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met
 65                  70                  75                  80 

Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr
                 85                  90                  95 

Tyr Cys Val Arg His Gly Asp Phe Asp Tyr Trp Gly Gln Gly Thr Thr
            100                 105                 110 

Leu Thr Val Ser Ser
        115        


<210>    35
<211>    114
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    7B7 heavy chain variable region


<400>    35
Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
  1               5                  10                  15 

Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asp Tyr
             20                  25                  30 

Tyr Met Tyr Trp Val Arg Gln Thr Pro Glu Arg Arg Leu Glu Trp Val
         35                  40                  45 

Ala Thr Ile Ser Asn Gly Gly Ser Tyr Ile Tyr Tyr Pro Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys
                 85                  90                  95 

Val Thr Glu Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
            100                 105                 110 

Ser Ser
       


<210>    36
<211>    111
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    A3F10 light chain variable region


<400>    36
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
             20                  25                  30 

Tyr Val Thr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
         35                  40                  45 

Ile Tyr Ala Asp Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
 65                  70                  75                  80 

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu
                 85                  90                  95 

Ser Gly Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110 


<210>    37
<211>    111
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    D3C6 light chain variable region


<400>    37
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ser Asn
             20                  25                  30 

Tyr Val Ser Trp Tyr Arg Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
         35                  40                  45 

Ile Tyr Ser Asp Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
 65                  70                  75                  80 

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Ala Ser Leu
                 85                  90                  95 

Ser Ala Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110 


<210>    38
<211>    112
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    4G3 light chain variable region


<400>    38
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly
  1               5                  10                  15 

Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
             20                  25                  30 

Arg Thr Arg Asn Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
         35                  40                  45 

Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
     50                  55                  60 

Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
 65                  70                  75                  80 

Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Trp Gln
                 85                  90                  95 

Ser Tyr Ser Leu Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105                 110 




<210>    39
<211>    112
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    5A7 light chain variable region


<400>    39
Asp Ile Val Met Thr Gln Ser Pro Leu Thr Leu Ser Val Thr Phe Gly
  1               5                  10                  15 

Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser
             20                  25                  30 

Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser
         35                  40                  45 

Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Ala Val Pro
     50                  55                  60 

Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
 65                  70                  75                  80 

Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly
                 85                  90                  95 

Thr His Phe Pro His Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105                 110 




<210>    40
<211>    112
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    7B7 light chain variable region


<400>    40
Asp Ile Val Met Thr Gln Ser Pro Leu Thr Leu Ser Val Thr Phe Gly
  1               5                  10                  15 

Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser
             20                  25                  30 

Asp Gly Glu Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser
         35                  40                  45 

Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Ala Val Pro
     50                  55                  60 

Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
 65                  70                  75                  80 

Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly
                 85                  90                  95 

Ser His Phe Pro His Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105                 110 




<210>    41
<211>    140
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    human a-synuclein amino acids


<400>    41
Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val
  1               5                  10                  15 

Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys
             20                  25                  30 

Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val
         35                  40                  45 

Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr
     50                  55                  60 

Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys
 65                  70                  75                  80 

Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys
                 85                  90                  95 

Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly Ile
            100                 105                 110 

Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro
        115                 120                 125 

Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala
    130                 135                 140
