                         SEQUENCE LISTING

<110>  㳱ҽҩƼϺ޹˾
 
<120>  RyR2׻RyR2鵰Ʊ˥ҩе;

<130>  ȨҪ ˵

<160>  30   

<170>  PatentIn version 3.3

<210>  1
<211>  189
<212>  PRT
<213>  SPRY1

<400>  1

Val Ser Ser Met Arg Pro Asn Ile Phe Leu Gly Val Ser Glu Gly Ser 
1               5                   10                  15      


Ala Gln Tyr Lys Lys Trp Tyr Tyr Glu Leu Met Val Asp His Thr Glu 
            20                  25                  30          


Pro Phe Val Thr Ala Glu Ala Thr His Leu Arg Val Gly Trp Ala Ser 
        35                  40                  45              


Thr Glu Gly Tyr Ser Pro Tyr Pro Gly Gly Gly Glu Glu Trp Gly Gly 
    50                  55                  60                  


Asn Gly Val Gly Asp Asp Leu Phe Ser Tyr Gly Phe Asp Gly Leu His 
65                  70                  75                  80  


Leu Trp Ser Gly Cys Ile Ala Arg Thr Val Ser Ser Pro Asn Gln His 
                85                  90                  95      


Leu Leu Arg Thr Asp Asp Val Ile Ser Cys Cys Leu Asp Leu Ser Ala 
            100                 105                 110         


Pro Ser Ile Ser Phe Arg Ile Asn Gly Gln Pro Val Gln Gly Met Phe 
        115                 120                 125             


Glu Asn Phe Asn Ile Asp Gly Leu Phe Phe Pro Val Val Ser Phe Ser 
    130                 135                 140                 


Ala Gly Ile Lys Val Arg Phe Leu Leu Gly Gly Arg His Gly Glu Phe 
145                 150                 155                 160 


Lys Phe Leu Pro Pro Pro Gly Tyr Ala Pro Cys Tyr Glu Ala Val Leu 
                165                 170                 175     


Pro Lys Glu Lys Leu Lys Val Glu His Ser Arg Glu Tyr 
            180                 185                 


<210>  2
<211>  567
<212>  DNA
<213>  SPRY1

<400>  2
gtgagcagca tgagacccaa catcttcctg ggcgtgagcg agggcagcgc ccagtacaag     60

aagtggtact acgagctgat ggtggaccac accgagccct tcgtgaccgc cgaggccacc    120

cacctgagag tgggctgggc cagcaccgag ggctacagcc cctaccccgg cggcggcgag    180

gagtggggcg gcaacggcgt gggcgacgac ctgttcagct acggcttcga cggcctgcac    240

ctgtggagcg gctgcatcgc cagaaccgtg agcagcccca accagcacct gctgagaacc    300

gacgacgtga tcagctgctg cctggacctg agcgccccca gcatcagctt cagaatcaac    360

ggccagcccg tgcagggcat gttcgagaac ttcaacatcg acggcctgtt cttccccgtg    420

gtgagcttca gcgccggcat caaggtgaga ttcctgctgg gcggcagaca cggcgagttc    480

aagttcctgc ccccccccgg ctacgccccc tgctacgagg ccgtgctgcc caaggagaag    540

ctgaaggtgg agcacagcag agagtac                                        567


<210>  3
<211>  205
<212>  PRT
<213>  P1

<400>  3

Phe Thr Pro Ile Pro Val Asp Thr Ser Gln Ile Val Leu Pro Pro His 
1               5                   10                  15      


Leu Glu Arg Ile Arg Glu Lys Leu Ala Glu Asn Ile His Glu Leu Trp 
            20                  25                  30          


Val Met Asn Lys Ile Glu Leu Gly Trp Gln Tyr Gly Pro Val Arg Asp 
        35                  40                  45              


Asp Asn Lys Arg Gln His Pro Cys Leu Val Glu Phe Ser Lys Leu Pro 
    50                  55                  60                  


Glu Gln Glu Arg Asn Tyr Asn Leu Gln Met Ser Leu Glu Thr Leu Lys 
65                  70                  75                  80  


Thr Leu Leu Ala Leu Gly Cys His Val Gly Ile Ser Asp Glu His Ala 
                85                  90                  95      


Glu Asp Lys Val Lys Lys Met Lys Leu Pro Lys Asn Tyr Gln Leu Thr 
            100                 105                 110         


Ser Gly Tyr Lys Pro Ala Pro Met Asp Leu Ser Phe Ile Lys Leu Thr 
        115                 120                 125             


Pro Ser Gln Glu Ala Met Val Asp Lys Leu Ala Glu Asn Ala His Asn 
    130                 135                 140                 


Val Trp Ala Arg Asp Arg Ile Arg Gln Gly Trp Thr Tyr Gly Ile Gln 
145                 150                 155                 160 


Gln Asp Val Lys Asn Arg Arg Asn Pro Arg Leu Val Pro Tyr Thr Leu 
                165                 170                 175     


Leu Asp Asp Arg Thr Lys Lys Ser Asn Lys Asp Ser Leu Arg Glu Ala 
            180                 185                 190         


Val Arg Thr Leu Leu Gly Tyr Gly Tyr Asn Leu Glu Ala 
        195                 200                 205 


<210>  4
<211>  615
<212>  DNA
<213>  P1

<400>  4
ttcaccccca tccccgtgga caccagccag atcgtgctgc ccccccacct ggagagaatc     60

agagagaagc tggccgagaa catccacgag ctgtgggtga tgaacaagat cgagctgggc    120

tggcagtacg gccccgtgag agacgacaac aagagacagc acccctgcct ggtggagttc    180

agcaagctgc ccgagcagga gagaaactac aacctgcaga tgagcctgga gaccctgaag    240

accctgctgg ccctgggctg ccacgtgggc atcagcgacg agcacgccga ggacaaggtg    300

aagaagatga agctgcccaa gaactaccag ctgaccagcg gctacaagcc cgcccccatg    360

gacctgagct tcatcaagct gacccccagc caggaggcca tggtggacaa gctggccgag    420

aacgcccaca acgtgtgggc cagagacaga atcagacagg gctggaccta cggcatccag    480

caggacgtga agaacagaag aaaccccaga ctggtgccct acaccctgct ggacgacaga    540

accaagaaga gcaacaagga cagcctgaga gaggccgtga gaaccctgct gggctacggc    600

tacaacctgg aggcc                                                     615


<210>  5
<211>  134
<212>  PRT
<213>  SPRY2

<400>  5

Arg Phe Arg Ile Phe Arg Ala Glu Lys Thr Tyr Ala Val Lys Ala Gly 
1               5                   10                  15      


Arg Trp Tyr Phe Glu Phe Glu Thr Val Thr Ala Gly Asp Met Arg Val 
            20                  25                  30          


Gly Trp Ser Arg Pro Gly Cys Gln Pro Asp Gln Glu Leu Gly Ser Asp 
        35                  40                  45              


Glu Arg Ala Phe Ala Phe Asp Gly Phe Lys Ala Gln Arg Trp His Gln 
    50                  55                  60                  


Gly Asn Glu His Tyr Gly Arg Ser Trp Gln Ala Gly Asp Val Val Gly 
65                  70                  75                  80  


Cys Met Val Asp Met Asn Glu His Thr Met Met Phe Thr Leu Asn Gly 
                85                  90                  95      


Glu Ile Leu Leu Asp Asp Ser Gly Ser Glu Leu Ala Phe Lys Asp Phe 
            100                 105                 110         


Asp Val Gly Asp Gly Phe Ile Pro Val Cys Ser Leu Gly Val Ala Gln 
        115                 120                 125             


Val Gly Arg Met Asn Phe 
    130                 


<210>  6
<211>  402
<212>  DNA
<213>  SPRY2

<400>  6
agattcagaa tcttcagagc cgagaagacc tacgccgtga aggccggcag atggtacttc     60

gagttcgaga ccgtgaccgc cggcgacatg agagtgggct ggagcagacc cggctgccag    120

cccgaccagg agctgggcag cgacgagaga gccttcgcct tcgacggctt caaggcccag    180

agatggcacc agggcaacga gcactacggc agaagctggc aggccggcga cgtggtgggc    240

tgcatggtgg acatgaacga gcacaccatg atgttcaccc tgaacggcga gatcctgctg    300

gacgacagcg gcagcgagct ggccttcaag gacttcgacg tgggcgacgg cttcatcccc    360

gtgtgcagcc tgggcgtggc ccaggtgggc agaatgaact tc                       402


<210>  7
<211>  398
<212>  PRT
<213>  SPRY3

<400>  7

Asn Arg Asp Ile Thr Met Trp Leu Ser Lys Arg Leu Pro Gln Phe Leu 
1               5                   10                  15      


Gln Val Pro Ser Asn His Glu His Ile Glu Val Thr Arg Ile Asp Gly 
            20                  25                  30          


Thr Ile Asp Ser Ser Pro Cys Leu Lys Val Thr Gln Lys Ser Phe Gly 
        35                  40                  45              


Ser Gln Asn Ser Asn Thr Asp Ile Met Phe Tyr Arg Leu Ser Met Pro 
    50                  55                  60                  


Ile Glu Cys Ala Glu Val Phe Ser Lys Thr Val Ala Gly Gly Leu Pro 
65                  70                  75                  80  


Gly Ala Gly Leu Phe Gly Pro Lys Asn Asp Leu Glu Asp Tyr Asp Ala 
                85                  90                  95      


Asp Ser Asp Phe Glu Val Leu Met Lys Thr Ala His Gly His Leu Val 
            100                 105                 110         


Pro Asp Arg Val Asp Lys Asp Lys Glu Ala Thr Lys Pro Glu Phe Asn 
        115                 120                 125             


Asn His Lys Asp Tyr Ala Gln Glu Lys Pro Ser Arg Leu Lys Gln Arg 
    130                 135                 140                 


Phe Leu Leu Arg Arg Thr Lys Pro Asp Tyr Ser Thr Ser His Ser Ala 
145                 150                 155                 160 


Arg Leu Thr Glu Asp Val Leu Ala Asp Asp Arg Asp Asp Tyr Asp Phe 
                165                 170                 175     


Leu Met Gln Thr Ser Thr Tyr Tyr Tyr Ser Val Arg Ile Phe Pro Gly 
            180                 185                 190         


Gln Glu Pro Ala Asn Val Trp Val Gly Trp Ile Thr Ser Asp Phe His 
        195                 200                 205             


Gln Tyr Asp Thr Gly Phe Asp Leu Asp Arg Val Arg Thr Val Thr Val 
    210                 215                 220                 


Thr Leu Gly Asp Glu Lys Gly Lys Val His Glu Ser Ile Lys Arg Ser 
225                 230                 235                 240 


Asn Cys Tyr Met Val Cys Ala Gly Glu Ser Met Ser Pro Gly Gln Gly 
                245                 250                 255     


Arg Asn Asn Asn Gly Leu Glu Ile Gly Cys Val Val Asp Ala Ala Ser 
            260                 265                 270         


Gly Leu Leu Thr Phe Ile Ala Asn Gly Lys Glu Leu Ser Thr Tyr Tyr 
        275                 280                 285             


Gln Val Glu Pro Ser Thr Lys Leu Phe Pro Ala Val Phe Ala Gln Ala 
    290                 295                 300                 


Thr Ser Pro Asn Val Phe Gln Phe Glu Leu Gly Arg Ile Lys Asn Val 
305                 310                 315                 320 


Met Pro Leu Ser Ala Gly Leu Phe Lys Ser Glu His Lys Asn Pro Val 
                325                 330                 335     


Pro Gln Cys Pro Pro Arg Leu His Val Gln Phe Leu Ser His Val Leu 
            340                 345                 350         


Trp Ser Arg Met Pro Asn Gln Phe Leu Lys Val Asp Val Ser Arg Ile 
        355                 360                 365             


Ser Glu Arg Gln Gly Trp Leu Val Gln Cys Leu Asp Pro Leu Gln Phe 
    370                 375                 380                 


Met Ser Leu His Ile Pro Glu Glu Asn Arg Ser Val Asp Ile 
385                 390                 395             


<210>  8
<211>  1194
<212>  DNA
<213>  SPRY3

<400>  8
aacagagaca tcaccatgtg gctgagcaag agactgcccc agttcctgca ggtgcccagc     60

aaccacgagc acatcgaggt gaccagaatc gacggcacca tcgacagcag cccctgcctg    120

aaggtgaccc agaagagctt cggcagccag aacagcaaca ccgacatcat gttctacaga    180

ctgagcatgc ccatcgagtg cgccgaggtg ttcagcaaga ccgtggccgg cggcctgccc    240

ggcgccggcc tgttcggccc caagaacgac ctggaggact acgacgccga cagcgacttc    300

gaggtgctga tgaagaccgc ccacggccac ctggtgcccg acagagtgga caaggacaag    360

gaggccacca agcccgagtt caacaaccac aaggactacg cccaggagaa gcccagcaga    420

ctgaagcaga gattcctgct gagaagaacc aagcccgact acagcaccag ccacagcgcc    480

agactgaccg aggacgtgct ggccgacgac agagacgact acgacttcct gatgcagacc    540

agcacctact actacagcgt gagaatcttc cccggccagg agcccgccaa cgtgtgggtg    600

ggctggatca ccagcgactt ccaccagtac gacaccggct tcgacctgga cagagtgaga    660

accgtgaccg tgaccctggg cgacgagaag ggcaaggtgc acgagagcat caagagaagc    720

aactgctaca tggtgtgcgc cggcgagagc atgagccccg gccagggcag aaacaacaac    780

ggcctggaga tcggctgcgt ggtggacgcc gccagcggcc tgctgacctt catcgccaac    840

ggcaaggagc tgagcaccta ctaccaggtg gagcccagca ccaagctgtt ccccgccgtg    900

ttcgcccagg ccaccagccc caacgtgttc cagttcgagc tgggcagaat caagaacgtg    960

atgcccctga gcgccggcct gttcaagagc gagcacaaga accccgtgcc ccagtgcccc   1020

cccagactgc acgtgcagtt cctgagccac gtgctgtgga gcagaatgcc caaccagttc   1080

ctgaaggtgg acgtgagcag aatcagcgag agacagggct ggctggtgca gtgcctggac   1140

cccctgcagt tcatgagcct gcacatcccc gaggagaaca gaagcgtgga catc         1194


<210>  9
<211>  458
<212>  PRT
<213>  HANDLE

<400>  9

Lys Phe His Tyr His Thr Leu Arg Leu Tyr Ser Ala Val Cys Ala Leu 
1               5                   10                  15      


Gly Asn His Arg Val Ala His Ala Leu Cys Ser His Val Asp Glu Pro 
            20                  25                  30          


Gln Leu Leu Tyr Ala Ile Glu Asn Lys Tyr Met Pro Gly Leu Leu Arg 
        35                  40                  45              


Ala Gly Tyr Tyr Asp Leu Leu Ile Asp Ile His Leu Ser Ser Tyr Ala 
    50                  55                  60                  


Thr Ala Arg Leu Met Met Asn Asn Glu Tyr Ile Val Pro Met Thr Glu 
65                  70                  75                  80  


Glu Thr Lys Ser Ile Thr Leu Phe Pro Asp Glu Asn Lys Lys His Gly 
                85                  90                  95      


Leu Pro Gly Ile Gly Leu Ser Thr Ser Leu Arg Pro Arg Met Gln Phe 
            100                 105                 110         


Ser Ser Pro Ser Phe Val Ser Ile Ser Asn Glu Cys Tyr Gln Tyr Ser 
        115                 120                 125             


Pro Glu Phe Pro Leu Asp Ile Leu Lys Ser Lys Thr Ile Gln Met Leu 
    130                 135                 140                 


Thr Glu Ala Val Lys Glu Gly Ser Leu His Ala Arg Asp Pro Val Gly 
145                 150                 155                 160 


Gly Thr Thr Glu Phe Leu Phe Val Pro Leu Ile Lys Leu Phe Tyr Thr 
                165                 170                 175     


Leu Leu Ile Met Gly Ile Phe His Asn Glu Asp Leu Lys His Ile Leu 
            180                 185                 190         


Gln Leu Ile Glu Pro Ser Val Phe Lys Glu Ala Ala Thr Pro Glu Glu 
        195                 200                 205             


Glu Ser Asp Thr Leu Glu Lys Glu Leu Ser Val Asp Asp Ala Lys Leu 
    210                 215                 220                 


Gln Gly Ala Gly Glu Glu Glu Ala Lys Gly Gly Lys Arg Pro Lys Glu 
225                 230                 235                 240 


Gly Leu Leu Gln Met Lys Leu Pro Glu Pro Val Lys Leu Gln Met Cys 
                245                 250                 255     


Leu Leu Leu Gln Tyr Leu Cys Asp Cys Gln Val Arg His Arg Ile Glu 
            260                 265                 270         


Ala Ile Val Ala Phe Ser Asp Asp Phe Val Ala Lys Leu Gln Asp Asn 
        275                 280                 285             


Gln Arg Phe Arg Tyr Asn Glu Val Met Gln Ala Leu Asn Met Ser Ala 
    290                 295                 300                 


Ala Leu Thr Ala Arg Lys Thr Lys Glu Phe Arg Ser Pro Pro Gln Glu 
305                 310                 315                 320 


Gln Ile Asn Met Leu Leu Asn Phe Lys Asp Asp Lys Ser Glu Cys Pro 
                325                 330                 335     


Cys Pro Glu Glu Ile Arg Asp Gln Leu Leu Asp Phe His Glu Asp Leu 
            340                 345                 350         


Met Thr His Cys Gly Ile Glu Leu Asp Glu Asp Gly Ser Leu Asp Gly 
        355                 360                 365             


Asn Ser Asp Leu Thr Ile Arg Gly Arg Leu Leu Ser Leu Val Glu Lys 
    370                 375                 380                 


Val Thr Tyr Leu Lys Lys Lys Gln Ala Glu Lys Pro Val Glu Ser Asp 
385                 390                 395                 400 


Ser Lys Lys Ser Ser Thr Leu Gln Gln Leu Ile Ser Glu Thr Met Val 
                405                 410                 415     


Arg Trp Ala Gln Glu Ser Val Ile Glu Asp Pro Glu Leu Val Arg Ala 
            420                 425                 430         


Met Phe Val Leu Leu His Arg Gln Tyr Asp Gly Ile Gly Gly Leu Val 
        435                 440                 445             


Arg Ala Leu Pro Lys Thr Tyr Thr Ile Asn 
    450                 455             


<210>  10
<211>  1374
<212>  DNA
<213>  HANDLE

<400>  10
aagttccact accacaccct gagactgtac agcgccgtgt gcgccctggg caaccacaga     60

gtggcccacg ccctgtgcag ccacgtggac gagccccagc tgctgtacgc catcgagaac    120

aagtacatgc ccggcctgct gagagccggc tactacgacc tgctgatcga catccacctg    180

agcagctacg ccaccgccag actgatgatg aacaacgagt acatcgtgcc catgaccgag    240

gagaccaaga gcatcaccct gttccccgac gagaacaaga agcacggcct gcccggcatc    300

ggcctgagca ccagcctgag acccagaatg cagttcagca gccccagctt cgtgagcatc    360

agcaacgagt gctaccagta cagccccgag ttccccctgg acatcctgaa gagcaagacc    420

atccagatgc tgaccgaggc cgtgaaggag ggcagcctgc acgccagaga ccccgtgggc    480

ggcaccaccg agttcctgtt cgtgcccctg atcaagctgt tctacaccct gctgatcatg    540

ggcatcttcc acaacgagga cctgaagcac atcctgcagc tgatcgagcc cagcgtgttc    600

aaggaggccg ccacccccga ggaggagagc gacaccctgg agaaggagct gagcgtggac    660

gacgccaagc tgcagggcgc cggcgaggag gaggccaagg gcggcaagag acccaaggag    720

ggcctgctgc agatgaagct gcccgagccc gtgaagctgc agatgtgcct gctgctgcag    780

tacctgtgcg actgccaggt gagacacaga atcgaggcca tcgtggcctt cagcgacgac    840

ttcgtggcca agctgcagga caaccagaga ttcagataca acgaggtgat gcaggccctg    900

aacatgagcg ccgccctgac cgccagaaag accaaggagt tcagaagccc cccccaggag    960

cagatcaaca tgctgctgaa cttcaaggac gacaagagcg agtgcccctg ccccgaggag   1020

atcagagacc agctgctgga cttccacgag gacctgatga cccactgcgg catcgagctg   1080

gacgaggacg gcagcctgga cggcaacagc gacctgacca tcagaggcag actgctgagc   1140

ctggtggaga aggtgaccta cctgaagaag aagcaggccg agaagcccgt ggagagcgac   1200

agcaagaaga gcagcaccct gcagcagctg atcagcgaga ccatggtgag atgggcccag   1260

gagagcgtga tcgaggaccc cgagctggtg agagccatgt tcgtgctgct gcacagacag   1320

tacgacggca tcggcggcct ggtgagagcc ctgcccaaga cctacaccat caac         1374


<210>  11
<211>  569
<212>  PRT
<213>  HD1

<400>  11

Gly Val Ser Val Glu Asp Thr Ile Asn Leu Leu Ala Ser Leu Gly Gln 
1               5                   10                  15      


Ile Arg Ser Leu Leu Ser Val Arg Met Gly Lys Glu Glu Glu Lys Leu 
            20                  25                  30          


Met Ile Arg Gly Leu Gly Asp Ile Met Asn Asn Lys Val Phe Tyr Gln 
        35                  40                  45              


His Pro Asn Leu Met Arg Ala Leu Gly Met His Glu Thr Val Met Glu 
    50                  55                  60                  


Val Met Val Asn Val Leu Gly Gly Gly Glu Ser Lys Glu Ile Thr Phe 
65                  70                  75                  80  


Pro Lys Met Val Ala Asn Cys Cys Arg Phe Leu Cys Tyr Phe Cys Arg 
                85                  90                  95      


Ile Ser Arg Gln Asn Gln Lys Ala Met Phe Asp His Leu Ser Tyr Leu 
            100                 105                 110         


Leu Glu Asn Ser Ser Val Gly Leu Ala Ser Pro Ala Met Arg Gly Ser 
        115                 120                 125             


Thr Pro Leu Asp Val Ala Ala Ala Ser Val Met Asp Asn Asn Glu Leu 
    130                 135                 140                 


Ala Leu Ala Leu Arg Glu Pro Asp Leu Glu Lys Val Val Arg Tyr Leu 
145                 150                 155                 160 


Ala Gly Cys Gly Leu Gln Ser Cys Gln Met Leu Val Ser Lys Gly Tyr 
                165                 170                 175     


Pro Asp Ile Gly Trp Asn Pro Val Glu Gly Glu Arg Tyr Leu Asp Phe 
            180                 185                 190         


Leu Arg Phe Ala Val Phe Cys Asn Gly Glu Ser Val Glu Glu Asn Ala 
        195                 200                 205             


Asn Val Val Val Arg Leu Leu Ile Arg Arg Pro Glu Cys Phe Gly Pro 
    210                 215                 220                 


Ala Leu Arg Gly Glu Gly Gly Asn Gly Leu Leu Ala Ala Met Glu Glu 
225                 230                 235                 240 


Ala Ile Lys Ile Ala Glu Asp Pro Ser Arg Asp Gly Pro Ser Pro Asn 
                245                 250                 255     


Ser Gly Ser Ser Lys Thr Leu Asp Thr Glu Glu Glu Glu Asp Asp Thr 
            260                 265                 270         


Ile His Met Gly Asn Ala Ile Met Thr Phe Tyr Ser Ala Leu Ile Asp 
        275                 280                 285             


Leu Leu Gly Arg Cys Ala Pro Glu Met His Leu Ile His Ala Gly Lys 
    290                 295                 300                 


Gly Glu Ala Ile Arg Ile Arg Ser Ile Leu Arg Ser Leu Ile Pro Leu 
305                 310                 315                 320 


Gly Asp Leu Val Gly Val Ile Ser Ile Ala Phe Gln Met Pro Thr Ile 
                325                 330                 335     


Ala Lys Asp Gly Asn Val Val Glu Pro Asp Met Ser Ala Gly Phe Cys 
            340                 345                 350         


Pro Asp His Lys Ala Ala Met Val Leu Phe Leu Asp Arg Val Tyr Gly 
        355                 360                 365             


Ile Glu Val Gln Asp Phe Leu Leu His Leu Leu Glu Val Gly Phe Leu 
    370                 375                 380                 


Pro Asp Leu Arg Ala Ala Ala Ser Leu Asp Thr Ala Ala Leu Ser Ala 
385                 390                 395                 400 


Thr Asp Met Ala Leu Ala Leu Asn Arg Tyr Leu Cys Thr Ala Val Leu 
                405                 410                 415     


Pro Leu Leu Thr Arg Cys Ala Pro Leu Phe Ala Gly Thr Glu His His 
            420                 425                 430         


Ala Ser Leu Ile Asp Ser Leu Leu His Thr Val Tyr Arg Leu Ser Lys 
        435                 440                 445             


Gly Cys Ser Leu Thr Lys Ala Gln Arg Asp Ser Ile Glu Val Cys Leu 
    450                 455                 460                 


Leu Ser Ile Cys Gly Gln Leu Arg Pro Ser Met Met Gln His Leu Leu 
465                 470                 475                 480 


Arg Arg Leu Val Phe Asp Val Pro Leu Leu Asn Glu His Ala Lys Met 
                485                 490                 495     


Pro Leu Lys Leu Leu Thr Asn His Tyr Glu Arg Cys Trp Lys Tyr Tyr 
            500                 505                 510         


Cys Leu Pro Gly Gly Trp Gly Asn Phe Gly Ala Ala Ser Glu Glu Glu 
        515                 520                 525             


Leu His Leu Ser Arg Lys Leu Phe Trp Gly Ile Phe Asp Ala Leu Ser 
    530                 535                 540                 


Gln Lys Lys Tyr Glu Gln Glu Leu Phe Lys Leu Ala Leu Pro Cys Leu 
545                 550                 555                 560 


Ser Ala Val Ala Gly Ala Leu Pro Pro 
                565                 


<210>  12
<211>  1707
<212>  DNA
<213>  HD1

<400>  12
ggcgtgagcg tggaggacac catcaacctg ctggccagcc tgggccagat cagaagcctg     60

ctgagcgtga gaatgggcaa ggaggaggag aagctgatga tcagaggcct gggcgacatc    120

atgaacaaca aggtgttcta ccagcacccc aacctgatga gagccctggg catgcacgag    180

accgtgatgg aggtgatggt gaacgtgctg ggcggcggcg agagcaagga gatcaccttc    240

cccaagatgg tggccaactg ctgcagattc ctgtgctact tctgcagaat cagcagacag    300

aaccagaagg ccatgttcga ccacctgagc tacctgctgg agaacagcag cgtgggcctg    360

gccagccccg ccatgagagg cagcaccccc ctggacgtgg ccgccgccag cgtgatggac    420

aacaacgagc tggccctggc cctgagagag cccgacctgg agaaggtggt gagatacctg    480

gccggctgcg gcctgcagag ctgccagatg ctggtgagca agggctaccc cgacatcggc    540

tggaaccccg tggagggcga gagatacctg gacttcctga gattcgccgt gttctgcaac    600

ggcgagagcg tggaggagaa cgccaacgtg gtggtgagac tgctgatcag aagacccgag    660

tgcttcggcc ccgccctgag aggcgagggc ggcaacggcc tgctggccgc catggaggag    720

gccatcaaga tcgccgagga ccccagcaga gacggcccca gccccaacag cggcagcagc    780

aagaccctgg acaccgagga ggaggaggac gacaccatcc acatgggcaa cgccatcatg    840

accttctaca gcgccctgat cgacctgctg ggcagatgcg cccccgagat gcacctgatc    900

cacgccggca agggcgaggc catcagaatc agaagcatcc tgagaagcct gatccccctg    960

ggcgacctgg tgggcgtgat cagcatcgcc ttccagatgc ccaccatcgc caaggacggc   1020

aacgtggtgg agcccgacat gagcgccggc ttctgccccg accacaaggc cgccatggtg   1080

ctgttcctgg acagagtgta cggcatcgag gtgcaggact tcctgctgca cctgctggag   1140

gtgggcttcc tgcccgacct gagagccgcc gccagcctgg acaccgccgc cctgagcgcc   1200

accgacatgg ccctggccct gaacagatac ctgtgcaccg ccgtgctgcc cctgctgacc   1260

agatgcgccc ccctgttcgc cggcaccgag caccacgcca gcctgatcga cagcctgctg   1320

cacaccgtgt acagactgag caagggctgc agcctgacca aggcccagag agacagcatc   1380

gaggtgtgcc tgctgagcat ctgcggccag ctgagaccca gcatgatgca gcacctgctg   1440

agaagactgg tgttcgacgt gcccctgctg aacgagcacg ccaagatgcc cctgaagctg   1500

ctgaccaacc actacgagag atgctggaag tactactgcc tgcccggcgg ctggggcaac   1560

ttcggcgccg ccagcgagga ggagctgcac ctgagcagaa agctgttctg gggcatcttc   1620

gacgccctga gccagaagaa gtacgagcag gagctgttca agctggccct gccctgcctg   1680

agcgccgtgg ccggcgccct gcccccc                                       1707


<210>  13
<211>  547
<212>  PRT
<213>  HD2

<400>  13

Tyr Phe Leu Ser Ala Ala Ser Arg Pro Leu Cys Ser Gly Gly His Ala 
1               5                   10                  15      


Ser Asn Lys Glu Lys Glu Met Val Thr Ser Leu Phe Cys Lys Leu Gly 
            20                  25                  30          


Val Leu Val Arg His Arg Ile Ser Leu Phe Gly Asn Asp Ala Thr Ser 
        35                  40                  45              


Ile Val Asn Cys Leu His Ile Leu Gly Gln Thr Leu Asp Ala Arg Thr 
    50                  55                  60                  


Val Met Lys Thr Gly Leu Glu Ser Val Lys Ser Ala Leu Arg Ala Phe 
65                  70                  75                  80  


Leu Asp Asn Ala Ala Glu Asp Leu Glu Lys Thr Met Glu Asn Leu Lys 
                85                  90                  95      


Gln Gly Gln Phe Thr His Thr Arg Asn Gln Pro Lys Gly Val Thr Gln 
            100                 105                 110         


Ile Ile Asn Tyr Thr Thr Val Ala Leu Leu Pro Met Leu Ser Ser Leu 
        115                 120                 125             


Phe Glu His Ile Gly Gln His Gln Phe Gly Glu Asp Leu Ile Leu Glu 
    130                 135                 140                 


Asp Val Gln Val Ser Cys Tyr Arg Ile Leu Thr Ser Leu Tyr Ala Leu 
145                 150                 155                 160 


Gly Thr Ser Lys Ser Ile Tyr Val Glu Arg Gln Arg Ser Ala Leu Gly 
                165                 170                 175     


Glu Cys Leu Ala Ala Phe Ala Gly Ala Phe Pro Val Ala Phe Leu Glu 
            180                 185                 190         


Thr His Leu Asp Lys His Asn Ile Tyr Ser Ile Tyr Asn Thr Lys Ser 
        195                 200                 205             


Ser Arg Glu Arg Ala Ala Leu Ser Leu Pro Thr Asn Val Glu Asp Val 
    210                 215                 220                 


Cys Pro Asn Ile Pro Ser Leu Glu Lys Leu Met Glu Glu Ile Val Glu 
225                 230                 235                 240 


Leu Ala Glu Ser Gly Ile Arg Tyr Thr Gln Met Pro His Val Met Glu 
                245                 250                 255     


Val Ile Leu Pro Met Leu Cys Ser Tyr Met Ser Arg Trp Trp Glu His 
            260                 265                 270         


Gly Pro Glu Asn Asn Pro Glu Arg Ala Glu Met Cys Cys Thr Ala Leu 
        275                 280                 285             


Asn Ser Glu His Met Asn Thr Leu Leu Gly Asn Ile Leu Lys Ile Ile 
    290                 295                 300                 


Tyr Asn Asn Leu Gly Ile Asp Glu Gly Ala Trp Met Lys Arg Leu Ala 
305                 310                 315                 320 


Val Phe Ser Gln Pro Ile Ile Asn Lys Val Lys Pro Gln Leu Leu Lys 
                325                 330                 335     


Thr His Phe Leu Pro Leu Met Glu Lys Leu Lys Lys Lys Ala Ala Thr 
            340                 345                 350         


Val Val Ser Glu Glu Asp His Leu Lys Ala Glu Ala Arg Gly Asp Met 
        355                 360                 365             


Ser Glu Ala Glu Leu Leu Ile Leu Asp Glu Phe Thr Thr Leu Ala Arg 
    370                 375                 380                 


Asp Leu Tyr Ala Phe Tyr Pro Leu Leu Ile Arg Phe Val Asp Tyr Asn 
385                 390                 395                 400 


Arg Ala Lys Trp Leu Lys Glu Pro Asn Pro Glu Ala Glu Glu Leu Phe 
                405                 410                 415     


Arg Met Val Ala Glu Val Phe Ile Tyr Trp Ser Lys Ser His Asn Phe 
            420                 425                 430         


Lys Arg Glu Glu Gln Asn Phe Val Val Gln Asn Glu Ile Asn Asn Met 
        435                 440                 445             


Ser Phe Leu Ile Thr Asp Thr Lys Ser Lys Met Ser Lys Ala Ala Val 
    450                 455                 460                 


Ser Asp Gln Glu Arg Lys Lys Met Lys Arg Lys Gly Asp Arg Tyr Ser 
465                 470                 475                 480 


Met Gln Thr Ser Leu Ile Val Ala Ala Leu Lys Arg Leu Leu Pro Ile 
                485                 490                 495     


Gly Leu Asn Ile Cys Ala Pro Gly Asp Gln Glu Leu Ile Ala Leu Ala 
            500                 505                 510         


Lys Asn Arg Phe Ser Leu Lys Asp Thr Glu Asp Glu Val Arg Asp Ile 
        515                 520                 525             


Ile Arg Ser Asn Ile His Leu Gln Gly Lys Leu Glu Asp Pro Ala Ile 
    530                 535                 540                 


Arg Trp Gln 
545         


<210>  14
<211>  1656
<212>  DNA
<213>  HD2

<400>  14
agatacagac acgactactt cctgagcgcc gccagcagac ccctgtgcag cggcggccac     60

gccagcaaca aggagaagga gatggtgacc agcctgttct gcaagctggg cgtgctggtg    120

agacacagaa tcagcctgtt cggcaacgac gccaccagca tcgtgaactg cctgcacatc    180

ctgggccaga ccctggacgc cagaaccgtg atgaagaccg gcctggagag cgtgaagagc    240

gccctgagag ccttcctgga caacgccgcc gaggacctgg agaagaccat ggagaacctg    300

aagcagggcc agttcaccca caccagaaac cagcccaagg gcgtgaccca gatcatcaac    360

tacaccaccg tggccctgct gcccatgctg agcagcctgt tcgagcacat cggccagcac    420

cagttcggcg aggacctgat cctggaggac gtgcaggtga gctgctacag aatcctgacc    480

agcctgtacg ccctgggcac cagcaagagc atctacgtgg agagacagag aagcgccctg    540

ggcgagtgcc tggccgcctt cgccggcgcc ttccccgtgg ccttcctgga gacccacctg    600

gacaagcaca acatctacag catctacaac accaagagca gcagagagag agccgccctg    660

agcctgccca ccaacgtgga ggacgtgtgc cccaacatcc ccagcctgga gaagctgatg    720

gaggagatcg tggagctggc cgagagcggc atcagataca cccagatgcc ccacgtgatg    780

gaggtgatcc tgcccatgct gtgcagctac atgagcagat ggtgggagca cggccccgag    840

aacaaccccg agagagccga gatgtgctgc accgccctga acagcgagca catgaacacc    900

ctgctgggca acatcctgaa gatcatctac aacaacctgg gcatcgacga gggcgcctgg    960

atgaagagac tggccgtgtt cagccagccc atcatcaaca aggtgaagcc ccagctgctg   1020

aagacccact tcctgcccct gatggagaag ctgaagaaga aggccgccac cgtggtgagc   1080

gaggaggacc acctgaaggc cgaggccaga ggcgacatga gcgaggccga gctgctgatc   1140

ctggacgagt tcaccaccct ggccagagac ctgtacgcct tctaccccct gctgatcaga   1200

ttcgtggact acaacagagc caagtggctg aaggagccca accccgaggc cgaggagctg   1260

ttcagaatgg tggccgaggt gttcatctac tggagcaaga gccacaactt caagagagag   1320

gagcagaact tcgtggtgca gaacgagatc aacaacatga gcttcctgat caccgacacc   1380

aagagcaaga tgagcaaggc cgccgtgagc gaccaggaga gaaagaagat gaagagaaag   1440

ggcgacagat acagcatgca gaccagcctg atcgtggccg ccctgaagag actgctgccc   1500

atcggcctga acatctgcgc ccccggcgac caggagctga tcgccctggc caagaacaga   1560

ttcagcctga aggacaccga ggacgaggtg agagacatca tcagaagcaa catccacctg   1620

cagggcaagc tggaggaccc cgccatcaga tggcag                             1656


<210>  15
<211>  385
<212>  PRT
<213>  Central domain

<400>  15

Tyr Phe Glu Asp Lys Leu Ile Glu Asp Leu Ala Lys Pro Gly Ala Glu 
1               5                   10                  15      


Pro Pro Glu Glu Asp Glu Gly Thr Lys Arg Val Asp Pro Leu His Gln 
            20                  25                  30          


Leu Ile Leu Leu Phe Ser Arg Thr Ala Leu Thr Glu Lys Cys Lys Leu 
        35                  40                  45              


Glu Glu Asp Phe Leu Tyr Met Ala Tyr Ala Asp Ile Met Ala Lys Ser 
    50                  55                  60                  


Cys His Asp Glu Glu Asp Asp Asp Gly Glu Glu Glu Val Lys Ser Phe 
65                  70                  75                  80  


Glu Glu Lys Glu Met Glu Lys Gln Lys Leu Leu Tyr Gln Gln Ala Arg 
                85                  90                  95      


Leu His Asp Arg Gly Ala Ala Glu Met Val Leu Gln Thr Ile Ser Ala 
            100                 105                 110         


Ser Lys Gly Glu Thr Gly Pro Met Val Ala Ala Thr Leu Lys Leu Gly 
        115                 120                 125             


Ile Ala Ile Leu Asn Gly Gly Asn Ser Thr Val Gln Gln Lys Met Leu 
    130                 135                 140                 


Asp Tyr Leu Lys Glu Lys Lys Asp Val Gly Phe Phe Gln Ser Leu Ala 
145                 150                 155                 160 


Gly Leu Met Gln Ser Cys Ser Val Leu Asp Leu Asn Ala Phe Glu Arg 
                165                 170                 175     


Gln Asn Lys Ala Glu Gly Leu Gly Met Val Thr Glu Glu Gly Ser Gly 
            180                 185                 190         


Glu Lys Val Leu Gln Asp Asp Glu Phe Thr Cys Asp Leu Phe Arg Phe 
        195                 200                 205             


Leu Gln Leu Leu Cys Glu Gly His Asn Ser Asp Phe Gln Asn Tyr Leu 
    210                 215                 220                 


Arg Thr Gln Thr Gly Asn Asn Thr Thr Val Asn Ile Ile Ile Ser Thr 
225                 230                 235                 240 


Val Asp Tyr Leu Leu Arg Val Gln Glu Ser Ile Ser Asp Phe Tyr Trp 
                245                 250                 255     


Tyr Tyr Ser Gly Lys Asp Val Ile Asp Glu Gln Gly Gln Arg Asn Phe 
            260                 265                 270         


Ser Lys Ala Ile Gln Val Ala Lys Gln Val Phe Asn Thr Leu Thr Glu 
        275                 280                 285             


Tyr Ile Gln Gly Pro Cys Thr Gly Asn Gln Gln Ser Leu Ala His Ser 
    290                 295                 300                 


Arg Leu Trp Asp Ala Val Val Gly Phe Leu His Val Phe Ala His Met 
305                 310                 315                 320 


Gln Met Lys Leu Ser Gln Asp Ser Ser Gln Ile Glu Leu Leu Lys Glu 
                325                 330                 335     


Leu Met Asp Leu Gln Lys Asp Met Val Val Met Leu Leu Ser Met Leu 
            340                 345                 350         


Glu Gly Asn Val Val Asn Gly Thr Ile Gly Lys Gln Met Val Asp Met 
        355                 360                 365             


Leu Val Glu Ser Ser Asn Asn Val Glu Met Ile Leu Lys Phe Phe Asp 
    370                 375                 380                 


Met 
385 


<210>  16
<211>  1155
<212>  DNA
<213>  Central domain

<400>  16
tacttcgagg acaagctgat cgaggacctg gccaagcccg gcgccgagcc ccccgaggag     60

gacgagggca ccaagagagt ggaccccctg caccagctga tcctgctgtt cagcagaacc    120

gccctgaccg agaagtgcaa gctggaggag gacttcctgt acatggccta cgccgacatc    180

atggccaaga gctgccacga cgaggaggac gacgacggcg aggaggaggt gaagagcttc    240

gaggagaagg agatggagaa gcagaagctg ctgtaccagc aggccagact gcacgacaga    300

ggcgccgccg agatggtgct gcagaccatc agcgccagca agggcgagac cggccccatg    360

gtggccgcca ccctgaagct gggcatcgcc atcctgaacg gcggcaacag caccgtgcag    420

cagaagatgc tggactacct gaaggagaag aaggacgtgg gcttcttcca gagcctggcc    480

ggcctgatgc agagctgcag cgtgctggac ctgaacgcct tcgagagaca gaacaaggcc    540

gagggcctgg gcatggtgac cgaggagggc agcggcgaga aggtgctgca ggacgacgag    600

ttcacctgcg acctgttcag attcctgcag ctgctgtgcg agggccacaa cagcgacttc    660

cagaactacc tgagaaccca gaccggcaac aacaccaccg tgaacatcat catcagcacc    720

gtggactacc tgctgagagt gcaggagagc atcagcgact tctactggta ctacagcggc    780

aaggacgtga tcgacgagca gggccagaga aacttcagca aggccatcca ggtggccaag    840

caggtgttca acaccctgac cgagtacatc cagggcccct gcaccggcaa ccagcagagc    900

ctggcccaca gcagactgtg ggacgccgtg gtgggcttcc tgcacgtgtt cgcccacatg    960

cagatgaagc tgagccagga cagcagccag atcgagctgc tgaaggagct gatggacctg   1020

cagaaggaca tggtggtgat gctgctgagc atgctggagg gcaacgtggt gaacggcacc   1080

atcggcaagc agatggtgga catgctggtg gagagcagca acaacgtgga gatgatcctg   1140

aagttcttcg acatg                                                    1155


<210>  17
<211>  61
<212>  PRT
<213>  EF-HAND

<400>  17

Leu Thr Ser Ser Asp Thr Phe Lys Glu Tyr Asp Pro Asp Gly Lys Gly 
1               5                   10                  15      


Val Ile Ser Lys Arg Asp Phe His Lys Ala Met Glu Ser His Lys His 
            20                  25                  30          


Tyr Thr Gln Ser Glu Thr Glu Phe Leu Leu Ser Cys Ala Glu Thr Asp 
        35                  40                  45              


Glu Asn Glu Thr Leu Asp Tyr Glu Glu Phe Val Lys Arg 
    50                  55                  60      


<210>  18
<211>  183
<212>  DNA
<213>  EF-HAND

<400>  18
ctgaccagca gcgacacctt caaggagtac gaccccgacg gcaagggcgt gatcagcaag     60

agagacttcc acaaggccat ggagagccac aagcactaca cccagagcga gaccgagttc    120

ctgctgagct gcgccgagac cgacgagaac gagaccctgg actacgagga gttcgtgaag    180

aga                                                                  183


<210>  19
<211>  117
<212>  PRT
<213>  U-motif

<400>  19

Pro Ala Lys Asp Ile Gly Phe Asn Val Ala Val Leu Leu Thr Asn Leu 
1               5                   10                  15      


Ser Glu His Met Pro Asn Asp Thr Arg Leu Gln Thr Phe Leu Glu Leu 
            20                  25                  30          


Ala Glu Ser Val Leu Asn Tyr Phe Gln Pro Phe Leu Gly Arg Ile Glu 
        35                  40                  45              


Ile Met Gly Ser Ala Lys Arg Ile Glu Arg Val Tyr Phe Glu Ile Ser 
    50                  55                  60                  


Glu Ser Ser Arg Thr Gln Trp Glu Lys Pro Gln Val Lys Glu Ser Lys 
65                  70                  75                  80  


Arg Gln Phe Ile Phe Asp Val Val Asn Glu Gly Gly Glu Lys Glu Lys 
                85                  90                  95      


Met Glu Leu Phe Val Asn Phe Cys Glu Asp Thr Ile Phe Glu Met Gln 
            100                 105                 110         


Leu Ala Ala Gln Ile 
        115         


<210>  20
<211>  351
<212>  DNA
<213>  U-motif

<400>  20
cccgccaagg acatcggctt caacgtggcc gtgctgctga ccaacctgag cgagcacatg     60

cccaacgaca ccagactgca gaccttcctg gagctggccg agagcgtgct gaactacttc    120

cagcccttcc tgggcagaat cgagatcatg ggcagcgcca agagaatcga gagagtgtac    180

ttcgagatca gcgagagcag cagaacccag tgggagaagc cccaggtgaa ggagagcaag    240

agacagttca tcttcgacgt ggtgaacgag ggcggcgaga aggagaagat ggagctgttc    300

gtgaacttct gcgaggacac catcttcgag atgcagctgg ccgcccagat c             351


<210>  21
<211>  207
<212>  PRT
<213>  P2

<400>  21

Asn Phe Asn Pro Gln Pro Val Asp Thr Ser Asn Ile Thr Ile Pro Glu 
1               5                   10                  15      


Lys Leu Glu Tyr Phe Ile Asn Lys Tyr Ala Glu His Ser His Asp Lys 
            20                  25                  30          


Trp Ser Met Asp Lys Leu Ala Asn Gly Trp Ile Tyr Gly Glu Ile Tyr 
        35                  40                  45              


Ser Asp Ser Ser Lys Val Gln Pro Leu Met Lys Pro Tyr Lys Leu Leu 
    50                  55                  60                  


Ser Glu Lys Glu Lys Glu Ile Tyr Arg Trp Pro Ile Lys Glu Ser Leu 
65                  70                  75                  80  


Lys Thr Met Leu Ala Trp Gly Trp Arg Ile Glu Arg Thr Arg Glu Gly 
                85                  90                  95      


Asp Ser Met Ala Leu Tyr Asn Arg Thr Arg Arg Ile Ser Gln Thr Ser 
            100                 105                 110         


Gln Val Ser Val Asp Ala Ala His Gly Tyr Ser Pro Arg Ala Ile Asp 
        115                 120                 125             


Met Ser Asn Val Thr Leu Ser Arg Asp Leu His Ala Met Ala Glu Met 
    130                 135                 140                 


Met Ala Glu Asn Tyr His Asn Ile Trp Ala Lys Lys Lys Lys Met Glu 
145                 150                 155                 160 


Leu Glu Ser Lys Gly Gly Gly Asn His Pro Leu Leu Val Pro Tyr Asp 
                165                 170                 175     


Thr Leu Thr Ala Lys Glu Lys Ala Lys Asp Arg Glu Lys Ala Gln Asp 
            180                 185                 190         


Ile Leu Lys Phe Leu Gln Ile Asn Gly Tyr Ala Val Ser Arg Gly 
        195                 200                 205         


<210>  22
<211>  621
<212>  DNA
<213>  P2

<400>  22
aacttcaacc cccagcccgt ggacaccagc aacatcacca tccccgagaa gctggagtac     60

ttcatcaaca agtacgccga gcacagccac gacaagtgga gcatggacaa gctggccaac    120

ggctggatct acggcgagat ctacagcgac agcagcaagg tgcagcccct gatgaagccc    180

tacaagctgc tgagcgagaa ggagaaggag atctacagat ggcccatcaa ggagagcctg    240

aagaccatgc tggcctgggg ctggagaatc gagagaacca gagagggcga cagcatggcc    300

ctgtacaaca gaaccagaag aatcagccag accagccagg tgagcgtgga cgccgcccac    360

ggctacagcc ccagagccat cgacatgagc aacgtgaccc tgagcagaga cctgcacgcc    420

atggccgaga tgatggccga gaactaccac aacatctggg ccaagaagaa gaagatggag    480

ctggagagca agggcggcgg caaccacccc ctgctggtgc cctacgacac cctgaccgcc    540

aaggagaagg ccaaggacag agagaaggcc caggacatcc tgaagttcct gcagatcaac    600

ggctacgccg tgagcagagg c                                              621


<210>  23
<211>  156
<212>  PRT
<213>  P2-peptide-1

<400>  23

Gln Pro Val Asp Thr Ser Asn Ile Thr Ile Pro Glu Lys Leu Glu Tyr 
1               5                   10                  15      


Phe Ile Asn Lys Tyr Ala Glu His Ser His Asp Lys Trp Ser Met Asp 
            20                  25                  30          


Lys Leu Ala Asn Gly Trp Ile Tyr Gly Glu Ile Tyr Ser Asp Ser Ser 
        35                  40                  45              


Lys Val Gln Pro Leu Met Lys Pro Tyr Lys Leu Leu Ser Glu Lys Glu 
    50                  55                  60                  


Lys Glu Ile Tyr Arg Trp Pro Ile Lys Glu Ser Leu Lys Thr Met Leu 
65                  70                  75                  80  


Ala Trp Gly Trp Arg Ile Glu Arg Thr Arg Glu Gly Asp Ser Met Ala 
                85                  90                  95      


Leu Tyr Asn Arg Thr Arg Arg Ile Ser Gln Thr Ser Gln Val Ser Val 
            100                 105                 110         


Asp Ala Ala His Gly Tyr Ser Pro Arg Ala Ile Asp Met Ser Asn Val 
        115                 120                 125             


Thr Leu Ser Arg Asp Leu His Ala Met Ala Glu Met Met Ala Glu Asn 
    130                 135                 140                 


Tyr His Asn Ile Trp Ala Lys Lys Lys Lys Met Glu 
145                 150                 155     


<210>  24
<211>  468
<212>  DNA
<213>  P2-peptide-1

<400>  24
cagcccgtgg acaccagcaa catcaccatc cccgagaagc tggagtactt catcaacaag     60

tacgccgagc acagccacga caagtggagc atggacaagc tggccaacgg ctggatctac    120

ggcgagatct acagcgacag cagcaaggtg cagcccctga tgaagcccta caagctgctg    180

agcgagaagg agaaggagat ctacagatgg cccatcaagg agagcctgaa gaccatgctg    240

gcctggggct ggagaatcga gagaaccaga gagggcgaca gcatggccct gtacaacaga    300

accagaagaa tcagccagac cagccaggtg agcgtggacg ccgcccacgg ctacagcccc    360

agagccatcg acatgagcaa cgtgaccctg agcagagacc tgcacgccat ggccgagatg    420

atggccgaga actaccacaa catctgggcc aagaagaaga agatggag                 468


<210>  25
<211>  69
<212>  PRT
<213>  P2-peptide-2

<400>  25

Ile Tyr Arg Trp Pro Ile Lys Glu Ser Leu Lys Thr Met Leu Ala Trp 
1               5                   10                  15      


Gly Trp Arg Ile Glu Arg Thr Arg Glu Gly Asp Ser Met Ala Leu Tyr 
            20                  25                  30          


Asn Arg Thr Arg Arg Ile Ser Gln Thr Ser Gln Val Ser Val Asp Ala 
        35                  40                  45              


Ala His Gly Tyr Ser Pro Arg Ala Ile Asp Met Ser Asn Val Thr Leu 
    50                  55                  60                  


Ser Arg Asp Leu His 
65                  


<210>  26
<211>  207
<212>  DNA
<213>  P2-peptide-2

<400>  26
atctacagat ggcccatcaa ggagagcctg aagaccatgc tggcctgggg ctggagaatc     60

gagagaacca gagagggcga cagcatggcc ctgtacaaca gaaccagaag aatcagccag    120

accagccagg tgagcgtgga cgccgcccac ggctacagcc ccagagccat cgacatgagc    180

aacgtgaccc tgagcagaga cctgcac                                        207


<210>  27
<211>  17
<212>  PRT
<213>  P2-Core-peptide

<400>  27

Thr Arg Arg Ile Ser Gln Thr Ser Gln Val Ser Val Asp Ala Ala His 
1               5                   10                  15      


Gly 
    


<210>  28
<211>  51
<212>  DNA
<213>  P2-Core-peptide

<400>  28
accagaagaa tcagccagac cagccaggtg agcgtggacg ccgcccacgg c              51

<210>  29
<211>  206
<212>  PRT
<213>  P2-mut

<400>  29

Asn Phe Asn Pro Gln Pro Val Asp Thr Ser Asn Ile Thr Ile Pro Glu 
1               5                   10                  15      


Lys Leu Glu Tyr Phe Ile Asn Lys Tyr Ala Glu His Ser His Asp Lys 
            20                  25                  30          


Trp Ser Met Asp Lys Leu Ala Asn Gly Trp Ile Tyr Gly Glu Ile Tyr 
        35                  40                  45              


Ser Asp Ser Ser Lys Ile Gln Pro Leu Met Lys Pro Tyr Lys Leu Leu 
    50                  55                  60                  


Ser Glu Lys Glu Lys Glu Ile Tyr Arg Trp Pro Ile Lys Glu Ser Leu 
65                  70                  75                  80  


Lys Thr Met Leu Ala Trp Gly Trp Arg Ile Glu Arg Thr Arg Glu Gly 
                85                  90                  95      


Asp Ser Met Ala Leu Tyr Asn Arg Thr Arg Arg Ile Ser Gln Thr Ser 
            100                 105                 110         


Gln Val Ser Ile Asp Ala Ala His Gly Tyr Ser Pro Arg Ala Ile Asp 
        115                 120                 125             


Met Ser Asn Val Thr Leu Ser Arg Asp Leu His Ala Met Ala Glu Met 
    130                 135                 140                 


Met Ala Glu Asn Tyr His Asn Ile Trp Ala Lys Lys Lys Lys Leu Glu 
145                 150                 155                 160 


Leu Glu Ser Lys Gly Gly Gly Asn His Pro Leu Leu Val Pro Tyr Asp 
                165                 170                 175     


Thr Leu Thr Ala Lys Glu Lys Ala Lys Asp Arg Glu Lys Ala Gln Asp 
            180                 185                 190         


Ile Leu Lys Phe Leu Gln Ile Asn Gly Tyr Ala Val Ser Arg 
        195                 200                 205     


<210>  30
<211>  618
<212>  DNA
<213>  P2-mut

<400>  30
aacttcaacc cccagcccgt ggacaccagc aacatcacca tccccgagaa gctggagtac       60

ttcatcaaca agtacgccga gcacagccac gacaagtgga gcatggacaa gctggccaac      120

ggctggatct acggcgagat ctacagcgac agcagcaaga tccagcccct gatgaagccc      180

tacaagctgc tgagcgagaa ggagaaggag atctacagat ggcccatcaa ggagagcctg      240

aagaccatgc tggcctgggg ctggagaatc gagagaacca gagagggcga cagcatggcc      300

ctgtacaaca gaaccagaag aatcagccag accagccagg tgagcatcga cgccgcccac      360

ggctacagcc ccagagccat cgacatgagc aacgtgaccc tgagcagaga cctgcacgcc      420

atggccgaga tgatggccga gaactaccac aacatctggg ccaagaagaa gaagctggag      480

ctggagagca agggcggcgg caaccacccc ctgctggtgc cctacgacac cctgaccgcc      540

aaggagaagg ccaaggacag agagaaggcc caggacatcc tgaagttcct gcagatcaac      600

ggctacgccg tgagcaga                                                    618



