                         SEQUENCE LISTING

<110>  The Broad Institute, Inc.
 
<120>  RNA PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND USES THEREOF

<130>  B1195.70055WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 62/695,777
<151>  2018-07-09

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  983
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Met Asn Ile Pro Ala Leu Val Glu Asn Gln Lys Lys Tyr Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ala Met Leu Asn Ala Gln Thr Val Leu Asp His Ile 
            20                  25                  30          


Gln Lys Val Ala Asp Ile Glu Gly Glu Gln Asn Glu Asn Asn Glu Asn 
        35                  40                  45              


Leu Trp Phe His Pro Val Met Ser His Leu Tyr Asn Ala Lys Asn Gly 
    50                  55                  60                  


Tyr Asp Lys Gln Pro Glu Lys Thr Met Phe Ile Ile Glu Arg Leu Gln 
65                  70                  75                  80  


Ser Tyr Phe Pro Phe Leu Lys Ile Met Ala Glu Asn Gln Arg Glu Tyr 
                85                  90                  95      


Ser Asn Gly Lys Tyr Lys Gln Asn Arg Val Glu Val Asn Ser Asn Asp 
            100                 105                 110         


Ile Phe Glu Val Leu Lys Arg Ala Phe Gly Val Leu Lys Met Tyr Arg 
        115                 120                 125             


Asp Leu Thr Asn Ala Tyr Lys Thr Tyr Glu Glu Lys Leu Asn Asp Gly 
    130                 135                 140                 


Cys Glu Phe Leu Thr Ser Thr Glu Gln Pro Leu Ser Gly Met Ile Asn 
145                 150                 155                 160 


Asn Tyr Tyr Thr Val Ala Leu Arg Asn Met Asn Glu Arg Tyr Gly Tyr 
                165                 170                 175     


Lys Thr Glu Asp Leu Ala Phe Ile Gln Asp Lys Arg Phe Lys Phe Val 
            180                 185                 190         


Lys Asp Ala Tyr Gly Lys Lys Lys Ser Gln Val Asn Thr Gly Phe Phe 
        195                 200                 205             


Leu Ser Leu Gln Asp Tyr Asn Gly Asp Thr Gln Lys Lys Leu His Leu 
    210                 215                 220                 


Ser Gly Val Gly Ile Ala Leu Leu Ile Cys Leu Phe Leu Asp Lys Gln 
225                 230                 235                 240 


Tyr Ile Asn Ile Phe Leu Ser Arg Leu Pro Ile Phe Ser Ser Tyr Asn 
                245                 250                 255     


Ala Gln Ser Glu Glu Arg Arg Ile Ile Ile Arg Ser Phe Gly Ile Asn 
            260                 265                 270         


Ser Ile Lys Leu Pro Lys Asp Arg Ile His Ser Glu Lys Ser Asn Lys 
        275                 280                 285             


Ser Val Ala Met Asp Met Leu Asn Glu Val Lys Arg Cys Pro Asp Glu 
    290                 295                 300                 


Leu Phe Thr Thr Leu Ser Ala Glu Lys Gln Ser Arg Phe Arg Ile Ile 
305                 310                 315                 320 


Ser Asp Asp His Asn Glu Val Leu Met Lys Arg Ser Ser Asp Arg Phe 
                325                 330                 335     


Val Pro Leu Leu Leu Gln Tyr Ile Asp Tyr Gly Lys Leu Phe Asp His 
            340                 345                 350         


Ile Arg Phe His Val Asn Met Gly Lys Leu Arg Tyr Leu Leu Lys Ala 
        355                 360                 365             


Asp Lys Thr Cys Ile Asp Gly Gln Thr Arg Val Arg Val Ile Glu Gln 
    370                 375                 380                 


Pro Leu Asn Gly Phe Gly Arg Leu Glu Glu Ala Glu Thr Met Arg Lys 
385                 390                 395                 400 


Gln Glu Asn Gly Thr Phe Gly Asn Ser Gly Ile Arg Ile Arg Asp Phe 
                405                 410                 415     


Glu Asn Met Lys Arg Asp Asp Ala Asn Pro Ala Asn Tyr Pro Tyr Ile 
            420                 425                 430         


Val Asp Thr Tyr Thr His Tyr Ile Leu Glu Asn Asn Lys Val Glu Met 
        435                 440                 445             


Phe Ile Asn Asp Lys Glu Asp Ser Ala Pro Leu Leu Pro Val Ile Glu 
    450                 455                 460                 


Asp Asp Arg Tyr Val Val Lys Thr Ile Pro Ser Cys Arg Met Ser Thr 
465                 470                 475                 480 


Leu Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Phe Gly Ser Lys 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Val Asp Val His Asn Arg Tyr Lys Arg Leu 
            500                 505                 510         


Phe Gln Ala Met Gln Lys Glu Glu Val Thr Ala Glu Asn Ile Ala Ser 
        515                 520                 525             


Phe Gly Ile Ala Glu Ser Asp Leu Pro Gln Lys Ile Leu Asp Leu Ile 
    530                 535                 540                 


Ser Gly Asn Ala His Gly Lys Asp Val Asp Ala Phe Ile Arg Leu Thr 
545                 550                 555                 560 


Val Asp Asp Met Leu Thr Asp Thr Glu Arg Arg Ile Lys Arg Phe Lys 
                565                 570                 575     


Asp Asp Arg Lys Ser Ile Arg Ser Ala Asp Asn Lys Met Gly Lys Arg 
            580                 585                 590         


Gly Phe Lys Gln Ile Ser Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Leu Phe Gln Pro Ser Val Asn Asp Gly Glu Asn Lys Ile 
    610                 615                 620                 


Thr Gly Leu Asn Tyr Arg Ile Met Gln Ser Ala Ile Ala Val Tyr Asp 
625                 630                 635                 640 


Ser Gly Asp Asp Tyr Glu Ala Lys Gln Gln Phe Lys Leu Met Phe Glu 
                645                 650                 655     


Lys Ala Arg Leu Ile Gly Lys Gly Thr Thr Glu Pro His Pro Phe Leu 
            660                 665                 670         


Tyr Lys Val Phe Ala Arg Ser Ile Pro Ala Asn Ala Val Glu Phe Tyr 
        675                 680                 685             


Glu Arg Tyr Leu Ile Glu Arg Lys Phe Tyr Leu Thr Gly Leu Ser Asn 
    690                 695                 700                 


Glu Ile Lys Lys Gly Asn Arg Val Asp Val Pro Phe Ile Arg Arg Asp 
705                 710                 715                 720 


Gln Asn Lys Trp Lys Thr Pro Ala Met Lys Thr Leu Gly Arg Ile Tyr 
                725                 730                 735     


Ser Glu Asp Leu Pro Val Glu Leu Pro Arg Gln Met Phe Asp Asn Glu 
            740                 745                 750         


Ile Lys Ser His Leu Lys Ser Leu Pro Gln Met Glu Gly Ile Asp Phe 
        755                 760                 765             


Asn Asn Ala Asn Val Thr Tyr Leu Ile Ala Glu Tyr Met Lys Arg Val 
    770                 775                 780                 


Leu Asp Asp Asp Phe Gln Thr Phe Tyr Gln Trp Asn Arg Asn Tyr Arg 
785                 790                 795                 800 


Tyr Met Asp Met Leu Lys Gly Glu Tyr Asp Arg Lys Gly Ser Leu Gln 
                805                 810                 815     


His Cys Phe Thr Ser Val Glu Glu Arg Glu Gly Leu Trp Lys Glu Arg 
            820                 825                 830         


Ala Ser Arg Thr Glu Arg Tyr Arg Lys Gln Ala Ser Asn Lys Ile Arg 
        835                 840                 845             


Ser Asn Arg Gln Met Arg Asn Ala Ser Ser Glu Glu Ile Glu Thr Ile 
    850                 855                 860                 


Leu Asp Lys Arg Leu Ser Asn Ser Arg Asn Glu Tyr Gln Lys Ser Glu 
865                 870                 875                 880 


Lys Val Ile Arg Arg Tyr Arg Val Gln Asp Ala Leu Leu Phe Leu Leu 
                885                 890                 895     


Ala Lys Lys Thr Leu Thr Glu Leu Ala Asp Phe Asp Gly Glu Arg Phe 
            900                 905                 910         


Lys Leu Lys Glu Ile Met Pro Asp Ala Glu Lys Gly Ile Leu Ser Glu 
        915                 920                 925             


Ile Met Pro Met Ser Phe Thr Phe Glu Lys Gly Gly Lys Lys Tyr Thr 
    930                 935                 940                 


Ile Thr Ser Glu Gly Met Lys Leu Lys Asn Tyr Gly Asp Phe Phe Val 
945                 950                 955                 960 


Leu Ala Ser Asp Lys Arg Ile Gly Asn Leu Leu Glu Leu Val Gly Ser 
                965                 970                 975     


Asp Ile Val Ser Lys Glu Asp 
            980             


<210>  2
<211>  967
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Met Ile Glu Lys Lys Lys Ser Phe Ala Lys Gly Met Gly Val Lys Ser 
1               5                   10                  15      


Thr Leu Val Ser Gly Ser Lys Val Tyr Met Thr Thr Phe Ala Glu Gly 
            20                  25                  30          


Ser Asp Ala Arg Leu Glu Lys Ile Val Glu Gly Asp Ser Ile Arg Ser 
        35                  40                  45              


Val Asn Glu Gly Glu Ala Phe Ser Ala Glu Met Ala Asp Lys Asn Ala 
    50                  55                  60                  


Gly Tyr Lys Ile Gly Asn Ala Lys Phe Ser His Pro Lys Gly Tyr Ala 
65                  70                  75                  80  


Val Val Ala Asn Asn Pro Leu Tyr Thr Gly Pro Val Gln Gln Asp Met 
                85                  90                  95      


Leu Gly Leu Lys Glu Thr Leu Glu Lys Arg Tyr Phe Gly Glu Ser Ala 
            100                 105                 110         


Asp Gly Asn Asp Asn Ile Cys Ile Gln Val Ile His Asn Ile Leu Asp 
        115                 120                 125             


Ile Glu Lys Ile Leu Ala Glu Tyr Ile Thr Asn Ala Ala Tyr Ala Val 
    130                 135                 140                 


Asn Asn Ile Ser Gly Leu Asp Lys Asp Ile Ile Gly Phe Gly Lys Phe 
145                 150                 155                 160 


Ser Thr Val Tyr Thr Tyr Asp Glu Phe Lys Asp Pro Glu His His Arg 
                165                 170                 175     


Ala Ala Phe Asn Asn Asn Asp Lys Leu Ile Asn Ala Ile Lys Ala Gln 
            180                 185                 190         


Tyr Asp Glu Phe Asp Asn Phe Leu Asp Asn Pro Arg Leu Gly Tyr Phe 
        195                 200                 205             


Gly Gln Ala Phe Phe Ser Lys Glu Gly Arg Asn Tyr Ile Ile Asn Tyr 
    210                 215                 220                 


Gly Asn Glu Cys Tyr Asp Ile Leu Ala Leu Leu Ser Gly Leu Ala His 
225                 230                 235                 240 


Trp Val Val Ala Asn Asn Glu Glu Glu Ser Arg Ile Ser Arg Thr Trp 
                245                 250                 255     


Leu Tyr Asn Leu Asp Lys Asn Leu Asp Asn Glu Tyr Ile Ser Thr Leu 
            260                 265                 270         


Asn Tyr Leu Tyr Asp Arg Ile Thr Asn Glu Leu Thr Asn Ser Phe Ser 
        275                 280                 285             


Lys Asn Ser Ala Ala Asn Val Asn Tyr Ile Ala Glu Thr Leu Gly Ile 
    290                 295                 300                 


Asn Pro Ala Glu Phe Ala Glu Gln Tyr Phe Arg Phe Ser Ile Met Lys 
305                 310                 315                 320 


Glu Gln Lys Asn Leu Gly Phe Asn Ile Thr Lys Leu Arg Glu Val Met 
                325                 330                 335     


Leu Asp Arg Lys Asp Met Ser Glu Ile Arg Lys Asn His Lys Val Phe 
            340                 345                 350         


Asp Ser Ile Arg Thr Lys Val Tyr Thr Met Met Asp Phe Val Ile Tyr 
        355                 360                 365             


Arg Tyr Tyr Ile Glu Glu Asp Ala Lys Val Ala Ala Ala Asn Lys Ser 
    370                 375                 380                 


Leu Pro Asp Asn Glu Lys Ser Leu Ser Glu Lys Asp Ile Phe Val Ile 
385                 390                 395                 400 


Asn Leu Arg Gly Ser Phe Asn Asp Asp Gln Lys Asp Ala Leu Tyr Tyr 
                405                 410                 415     


Asp Glu Ala Asn Arg Ile Trp Arg Lys Leu Glu Asn Ile Met His Asn 
            420                 425                 430         


Ile Lys Glu Phe Arg Gly Asn Lys Thr Arg Glu Tyr Lys Lys Lys Asp 
        435                 440                 445             


Ala Pro Arg Leu Pro Arg Ile Leu Pro Ala Gly Arg Asp Val Ser Ala 
    450                 455                 460                 


Phe Ser Lys Leu Met Tyr Ala Leu Thr Met Phe Leu Asp Gly Lys Glu 
465                 470                 475                 480 


Ile Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile Gln 
                485                 490                 495     


Ser Phe Leu Lys Val Met Pro Leu Ile Gly Val Asn Ala Lys Phe Val 
            500                 505                 510         


Glu Glu Tyr Ala Phe Phe Lys Asp Ser Ala Lys Ile Ala Asp Glu Leu 
        515                 520                 525             


Arg Leu Ile Lys Ser Phe Ala Arg Met Gly Glu Pro Ile Ala Asp Ala 
    530                 535                 540                 


Arg Arg Ala Met Tyr Ile Asp Ala Ile Arg Ile Leu Gly Thr Asn Leu 
545                 550                 555                 560 


Ser Tyr Asp Glu Leu Lys Ala Leu Ala Asp Thr Phe Ser Leu Asp Glu 
                565                 570                 575     


Asn Gly Asn Lys Leu Lys Lys Gly Lys His Gly Met Arg Asn Phe Ile 
            580                 585                 590         


Ile Asn Asn Val Ile Ser Asn Lys Arg Phe His Tyr Leu Ile Arg Tyr 
        595                 600                 605             


Gly Asp Pro Ala His Leu His Glu Ile Ala Lys Asn Glu Ala Val Val 
    610                 615                 620                 


Lys Phe Val Leu Gly Arg Ile Ala Asp Ile Gln Lys Lys Gln Gly Gln 
625                 630                 635                 640 


Asn Gly Lys Asn Gln Ile Asp Arg Tyr Tyr Glu Thr Cys Ile Gly Lys 
                645                 650                 655     


Asp Lys Gly Lys Ser Val Ser Glu Lys Val Asp Ala Leu Thr Lys Ile 
            660                 665                 670         


Ile Thr Gly Met Asn Tyr Asp Gln Phe Asp Lys Lys Arg Ser Val Ile 
        675                 680                 685             


Glu Asp Thr Gly Arg Glu Asn Ala Glu Arg Glu Lys Phe Lys Lys Ile 
    690                 695                 700                 


Ile Ser Leu Tyr Leu Thr Val Ile Tyr His Ile Leu Lys Asn Ile Val 
705                 710                 715                 720 


Asn Ile Asn Ala Arg Tyr Val Ile Gly Phe His Cys Val Glu Arg Asp 
                725                 730                 735     


Ala Gln Leu Tyr Lys Glu Lys Gly Tyr Asp Ile Asn Leu Lys Lys Leu 
            740                 745                 750         


Glu Glu Lys Gly Phe Ser Ser Val Thr Lys Leu Cys Ala Gly Ile Asp 
        755                 760                 765             


Glu Thr Ala Pro Asp Lys Arg Lys Asp Val Glu Lys Glu Met Ala Glu 
    770                 775                 780                 


Arg Ala Lys Glu Ser Ile Asp Ser Leu Glu Ser Ala Asn Pro Lys Leu 
785                 790                 795                 800 


Tyr Ala Asn Tyr Ile Lys Tyr Ser Asp Glu Lys Lys Ala Glu Glu Phe 
                805                 810                 815     


Thr Arg Gln Ile Asn Arg Glu Lys Ala Lys Thr Ala Leu Asn Ala Tyr 
            820                 825                 830         


Leu Arg Asn Thr Lys Trp Asn Val Ile Ile Arg Glu Asp Leu Leu Arg 
        835                 840                 845             


Ile Asp Asn Lys Thr Cys Thr Leu Phe Ala Asn Lys Ala Val Ala Leu 
    850                 855                 860                 


Glu Val Ala Arg Tyr Val His Ala Tyr Ile Asn Asp Ile Ala Glu Val 
865                 870                 875                 880 


Asn Ser Tyr Phe Gln Leu Tyr His Tyr Ile Met Gln Arg Ile Ile Met 
                885                 890                 895     


Asn Glu Arg Tyr Glu Lys Ser Ser Gly Lys Val Ser Glu Tyr Phe Asp 
            900                 905                 910         


Ala Val Asn Asp Glu Lys Lys Tyr Asn Asp Arg Leu Leu Lys Leu Leu 
        915                 920                 925             


Cys Val Pro Phe Gly Tyr Cys Ile Pro Arg Phe Lys Asn Leu Ser Ile 
    930                 935                 940                 


Glu Ala Leu Phe Asp Arg Asn Glu Ala Ala Lys Phe Asp Lys Glu Lys 
945                 950                 955                 960 


Lys Lys Val Ser Gly Asn Ser 
                965         


<210>  3
<211>  580
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Met Ser Asp Thr Trp Ser Ser Ile Gln Ala His Lys Lys Gln Leu Asp 
1               5                   10                  15      


Ser Leu Arg Glu Arg Leu Gln Arg Arg Arg Lys Gln Asp Ser Gly His 
            20                  25                  30          


Leu Asp Leu Arg Asn Pro Glu Ala Ala Leu Ser Pro Thr Phe Arg Ser 
        35                  40                  45              


Asp Ser Pro Val Pro Thr Ala Pro Thr Ser Gly Gly Pro Lys Pro Ser 
    50                  55                  60                  


Thr Ala Ser Ala Val Pro Glu Leu Ala Thr Asp Pro Glu Leu Glu Lys 
65                  70                  75                  80  


Lys Leu Leu His His Leu Ser Asp Leu Ala Leu Thr Leu Pro Thr Asp 
                85                  90                  95      


Ala Val Ser Ile Cys Leu Ala Ile Ser Thr Pro Asp Ala Pro Ala Thr 
            100                 105                 110         


Gln Asp Gly Val Glu Ser Leu Leu Gln Lys Phe Ala Ala Gln Glu Leu 
        115                 120                 125             


Ile Glu Val Lys Arg Gly Leu Leu Gln Asp Asp Ala His Pro Thr Leu 
    130                 135                 140                 


Val Thr Tyr Ala Asp His Ser Lys Leu Ser Ala Met Met Gly Ala Val 
145                 150                 155                 160 


Ala Glu Lys Lys Gly Pro Gly Glu Val Ala Gly Thr Val Thr Gly Gln 
                165                 170                 175     


Lys Arg Arg Ala Glu Gln Asp Ser Thr Thr Val Ala Ala Phe Ala Ser 
            180                 185                 190         


Ser Leu Val Ser Gly Leu Asn Ser Ser Ala Ser Glu Pro Ala Lys Glu 
        195                 200                 205             


Pro Ala Lys Lys Ser Arg Lys His Ala Ala Ser Asp Val Asp Leu Glu 
    210                 215                 220                 


Ile Glu Ser Leu Leu Asn Gln Gln Ser Thr Lys Glu Gln Gln Ser Lys 
225                 230                 235                 240 


Lys Val Ser Gln Glu Ile Leu Glu Leu Leu Asn Thr Thr Thr Ala Lys 
                245                 250                 255     


Glu Gln Ser Ile Val Glu Lys Phe Arg Ser Arg Gly Arg Ala Gln Val 
            260                 265                 270         


Gln Glu Phe Cys Asp Tyr Gly Thr Lys Glu Glu Cys Met Lys Ala Ser 
        275                 280                 285             


Asp Ala Asp Arg Pro Cys Arg Lys Leu His Phe Arg Arg Ile Ile Asn 
    290                 295                 300                 


Lys His Thr Asp Glu Ser Leu Gly Asp Cys Ser Phe Leu Asn Thr Cys 
305                 310                 315                 320 


Phe His Met Asp Thr Cys Lys Tyr Val His Tyr Glu Ile Asp Ala Cys 
                325                 330                 335     


Met Asp Ser Glu Ala Pro Gly Ser Lys Asp His Thr Pro Ser Gln Glu 
            340                 345                 350         


Leu Ala Leu Thr Gln Ser Val Gly Gly Asp Ser Ser Ala Asp Arg Leu 
        355                 360                 365             


Phe Pro Pro Gln Trp Ile Cys Cys Asp Ile Arg Tyr Leu Asp Val Ser 
    370                 375                 380                 


Ile Leu Gly Lys Phe Ala Val Val Met Ala Asp Pro Pro Trp Asp Ile 
385                 390                 395                 400 


His Met Glu Leu Pro Tyr Gly Thr Leu Thr Asp Asp Glu Met Arg Arg 
                405                 410                 415     


Leu Asn Ile Pro Val Leu Gln Asp Asp Gly Phe Leu Phe Leu Trp Val 
            420                 425                 430         


Thr Gly Arg Ala Met Glu Leu Gly Arg Glu Cys Leu Asn Leu Trp Gly 
        435                 440                 445             


Tyr Glu Arg Val Asp Glu Ile Ile Trp Val Lys Thr Asn Gln Leu Gln 
    450                 455                 460                 


Arg Ile Ile Arg Thr Gly Arg Thr Gly His Trp Leu Asn His Gly Lys 
465                 470                 475                 480 


Glu His Cys Leu Val Gly Val Lys Gly Asn Pro Gln Gly Phe Asn Gln 
                485                 490                 495     


Gly Leu Asp Cys Asp Val Ile Val Ala Glu Val Arg Ser Thr Ser His 
            500                 505                 510         


Lys Pro Asp Glu Ile Tyr Gly Met Ile Glu Arg Leu Ser Pro Gly Thr 
        515                 520                 525             


Arg Lys Ile Glu Leu Phe Gly Arg Pro His Asn Val Gln Pro Asn Trp 
    530                 535                 540                 


Ile Thr Leu Gly Asn Gln Leu Asp Gly Ile His Leu Leu Asp Pro Asp 
545                 550                 555                 560 


Val Val Ala Arg Phe Lys Gln Arg Tyr Pro Asp Gly Ile Ile Ser Lys 
                565                 570                 575     


Pro Lys Asn Leu 
            580 


<210>  4
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Met Asp Ser Arg Leu Gln Glu Ile Arg Glu Arg Gln Lys Leu Arg Arg 
1               5                   10                  15      


Gln Leu Leu Ala Gln Gln Leu Gly Ala Glu Ser Ala Asp Ser Ile Gly 
            20                  25                  30          


Ala Val Leu Asn Ser Lys Asp Glu Gln Arg Glu Ile Ala Glu Thr Arg 
        35                  40                  45              


Glu Thr Cys Arg Ala Ser Tyr Asp Thr Ser Ala Pro Asn Ala Lys Arg 
    50                  55                  60                  


Lys Tyr Leu Asp Glu Gly Glu Thr Asp Glu Asp Lys Met Glu Glu Tyr 
65                  70                  75                  80  


Lys Asp Glu Leu Glu Met Gln Gln Asp Glu Glu Asn Leu Pro Tyr Glu 
                85                  90                  95      


Glu Glu Ile Tyr Lys Asp Ser Ser Thr Phe Leu Lys Gly Thr Gln Ser 
            100                 105                 110         


Leu Asn Pro His Asn Asp Tyr Cys Gln His Phe Val Asp Thr Gly His 
        115                 120                 125             


Arg Pro Gln Asn Phe Ile Arg Asp Val Gly Leu Ala Asp Arg Phe Glu 
    130                 135                 140                 


Glu Tyr Pro Lys Leu Arg Glu Leu Ile Arg Leu Lys Asp Glu Leu Ile 
145                 150                 155                 160 


Ala Lys Ser Asn Thr Pro Pro Met Tyr Leu Gln Ala Asp Ile Glu Ala 
                165                 170                 175     


Phe Asp Ile Arg Glu Leu Thr Pro Lys Phe Asp Val Ile Leu Leu Glu 
            180                 185                 190         


Pro Pro Leu Glu Glu Tyr Tyr Arg Glu Thr Gly Ile Thr Ala Asn Glu 
        195                 200                 205             


Lys Cys Trp Thr Trp Asp Asp Ile Met Lys Leu Glu Ile Asp Glu Ile 
    210                 215                 220                 


Ala Ala Pro Arg Ser Phe Ile Phe Leu Trp Cys Gly Ser Gly Glu Gly 
225                 230                 235                 240 


Leu Asp Leu Gly Arg Val Cys Leu Arg Lys Trp Gly Tyr Arg Arg Cys 
                245                 250                 255     


Glu Asp Ile Cys Trp Ile Lys Thr Asn Lys Asn Asn Pro Gly Lys Thr 
            260                 265                 270         


Lys Thr Leu Asp Pro Lys Ala Val Phe Gln Arg Thr Lys Glu His Cys 
        275                 280                 285             


Leu Met Gly Ile Lys Gly Thr Val Lys Arg Ser Thr Asp Gly Asp Phe 
    290                 295                 300                 


Ile His Ala Asn Val Asp Ile Asp Leu Ile Ile Thr Glu Glu Pro Glu 
305                 310                 315                 320 


Ile Gly Asn Ile Glu Lys Pro Val Glu Ile Phe His Ile Ile Glu His 
                325                 330                 335     


Phe Cys Leu Gly Arg Arg Arg Leu His Leu Phe Gly Arg Asp Ser Thr 
            340                 345                 350         


Ile Arg Pro Gly Trp Leu Thr Val Gly Pro Thr Leu Thr Asn Ser Asn 
        355                 360                 365             


Tyr Asn Ala Glu Thr Tyr Ala Ser Tyr Phe Ser Ala Pro Asn Ser Tyr 
    370                 375                 380                 


Leu Thr Gly Cys Thr Glu Glu Ile Glu Arg Leu Arg Pro Lys Ser Pro 
385                 390                 395                 400 


Pro Pro Lys Ser Lys Ser Asp Arg Gly Gly Gly Ala Pro Arg Gly Gly 
                405                 410                 415     


Gly Arg Gly Gly Thr Ser Ala Gly Arg Gly Arg Glu Arg Asn Arg Ser 
            420                 425                 430         


Asn Phe Arg Gly Glu Arg Gly Gly Phe Arg Gly Gly Arg Gly Gly Ala 
        435                 440                 445             


His Arg Gly Gly Phe Pro Pro Arg 
    450                 455     


<210>  5
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Met Leu Asn Thr Val Lys Ile Ser Ser Cys Glu Leu Ile Asn Ala Asp 
1               5                   10                  15      


Cys Leu Glu Phe Ile Arg Ser Leu Pro Glu Asn Ser Val Asp Leu Ile 
            20                  25                  30          


Val Thr Asp Pro Pro Tyr Phe Lys Val Lys Pro Glu Gly Trp Asp Asn 
        35                  40                  45              


Gln Trp Lys Gly Asp Asp Asp Tyr Leu Lys Trp Leu Asp Gln Cys Leu 
    50                  55                  60                  


Ala Gln Phe Trp Arg Val Leu Lys Pro Ala Gly Ser Leu Tyr Leu Phe 
65                  70                  75                  80  


Cys Gly His Arg Leu Ala Ser Asp Ile Glu Ile Met Met Arg Glu Arg 
                85                  90                  95      


Phe Ser Val Leu Asn His Ile Ile Trp Ala Lys Pro Ser Gly Arg Trp 
            100                 105                 110         


Asn Gly Cys Asn Lys Glu Ser Leu Arg Ala Tyr Phe Pro Ala Thr Glu 
        115                 120                 125             


Arg Ile Leu Phe Ala Glu His Tyr Gln Gly Pro Tyr Arg Pro Lys Asp 
    130                 135                 140                 


Ala Gly Tyr Glu Ala Lys Gly Arg Ala Leu Lys Gln His Val Met Ala 
145                 150                 155                 160 


Pro Leu Ile Ala Tyr Phe Arg Asp Ala Arg Ala Ala Leu Gly Ile Thr 
                165                 170                 175     


Ala Lys Gln Ile Ala Asp Ala Thr Gly Lys Lys Asn Met Val Pro His 
            180                 185                 190         


Trp Phe Ser Ala Ser Gln Trp Gln Leu Pro Asn Glu Ser Asp Tyr Leu 
        195                 200                 205             


Lys Leu Gln Ser Leu Phe Ala Arg Val Ala Glu Glu Lys His Gln Arg 
    210                 215                 220                 


Gly Glu Leu Glu Lys Pro His His Gln Leu Val Ser Thr Tyr Ser Glu 
225                 230                 235                 240 


Leu Asn Arg Lys Tyr Met Glu Leu Leu Ser Glu Tyr Lys Asn Leu Arg 
                245                 250                 255     


Arg Tyr Phe Gly Val Thr Val Gln Val Pro Tyr Thr Asp Val Trp Thr 
            260                 265                 270         


Tyr Lys Pro Val Gln Tyr Tyr Pro Gly Lys His Pro Cys Glu Lys Pro 
        275                 280                 285             


Ala Glu Met Leu Gln Gln Ile Ile Ser Ala Ser Ser Arg Pro Gly Asp 
    290                 295                 300                 


Leu Val Ala Asp Phe Phe Met Gly Ser Gly Ser Thr Val Lys Ala Ala 
305                 310                 315                 320 


Met Ala Leu Gly Arg Arg Ala Ile Gly Val Glu Leu Glu Thr Gly Arg 
                325                 330                 335     


Phe Glu Gln Thr Val Arg Glu Val Gln Asp Leu Ile Val 
            340                 345                 


<210>  6
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Met Ser Ala Thr Gly Pro Phe Ser Ile Gly Glu Arg Val Gln Leu Thr 
1               5                   10                  15      


Asp Ala Lys Gly Arg Arg Tyr Thr Met Ser Leu Thr Pro Gly Ala Glu 
            20                  25                  30          


Phe His Thr His Arg Gly Ser Ile Ala His Asp Ala Val Ile Gly Leu 
        35                  40                  45              


Glu Gln Gly Ser Val Val Lys Ser Ser Asn Gly Ala Leu Phe Leu Val 
    50                  55                  60                  


Leu Arg Pro Leu Leu Val Asp Tyr Val Met Ser Met Pro Arg Gly Pro 
65                  70                  75                  80  


Gln Val Ile Tyr Pro Lys Asp Ala Ala Gln Ile Val His Glu Gly Asp 
                85                  90                  95      


Ile Phe Pro Gly Ala Arg Val Leu Glu Ala Gly Ala Gly Ser Gly Ala 
            100                 105                 110         


Leu Thr Leu Ser Leu Leu Arg Ala Val Gly Pro Ala Gly Gln Val Ile 
        115                 120                 125             


Ser Tyr Glu Gln Arg Ala Asp His Ala Glu His Ala Arg Arg Asn Val 
    130                 135                 140                 


Ser Gly Cys Tyr Gly Gln Pro Pro Asp Asn Trp Arg Leu Val Val Ser 
145                 150                 155                 160 


Asp Leu Ala Asp Ser Glu Leu Pro Asp Gly Ser Val Asp Arg Ala Val 
                165                 170                 175     


Leu Asp Met Leu Ala Pro Trp Glu Val Leu Asp Ala Val Ser Arg Leu 
            180                 185                 190         


Leu Val Ala Gly Gly Val Leu Met Val Tyr Val Ala Thr Val Thr Gln 
        195                 200                 205             


Leu Ser Arg Ile Val Glu Ala Leu Arg Ala Lys Gln Cys Trp Thr Glu 
    210                 215                 220                 


Pro Arg Ala Trp Glu Thr Leu Gln Arg Gly Trp Asn Val Val Gly Leu 
225                 230                 235                 240 


Ala Val Arg Pro Gln His Ser Met Arg Gly His Thr Ala Phe Leu Val 
                245                 250                 255     


Ala Thr Arg Arg Leu Ala Pro Gly Ala Val Ala Pro Ala Pro Leu Gly 
            260                 265                 270         


Arg Lys Arg Glu Gly Arg Asp Gly 
        275                 280 


<210>  7
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  7

Met Leu Met Ala Trp Cys Arg Gly Pro Val Leu Leu Cys Leu Arg Gln 
1               5                   10                  15      


Gly Leu Gly Thr Asn Ser Phe Leu His Gly Leu Gly Gln Glu Pro Phe 
            20                  25                  30          


Glu Gly Ala Arg Ser Leu Cys Cys Arg Ser Ser Pro Arg Asp Leu Arg 
        35                  40                  45              


Asp Gly Glu Arg Glu His Glu Ala Ala Gln Arg Lys Ala Pro Gly Ala 
    50                  55                  60                  


Glu Ser Cys Pro Ser Leu Pro Leu Ser Ile Ser Asp Ile Gly Thr Gly 
65                  70                  75                  80  


Cys Leu Ser Ser Leu Glu Asn Leu Arg Leu Pro Thr Leu Arg Glu Glu 
                85                  90                  95      


Ser Ser Pro Arg Glu Leu Glu Asp Ser Ser Gly Asp Gln Gly Arg Cys 
            100                 105                 110         


Gly Pro Thr His Gln Gly Ser Glu Asp Pro Ser Met Leu Ser Gln Ala 
        115                 120                 125             


Gln Ser Ala Thr Glu Val Glu Glu Arg His Val Ser Pro Ser Cys Ser 
    130                 135                 140                 


Thr Ser Arg Glu Arg Pro Phe Gln Ala Gly Glu Leu Ile Leu Ala Glu 
145                 150                 155                 160 


Thr Gly Glu Gly Glu Thr Lys Phe Lys Lys Leu Phe Arg Leu Asn Asn 
                165                 170                 175     


Phe Gly Leu Leu Asn Ser Asn Trp Gly Ala Val Pro Phe Gly Lys Ile 
            180                 185                 190         


Val Gly Lys Phe Pro Gly Gln Ile Leu Arg Ser Ser Phe Gly Lys Gln 
        195                 200                 205             


Tyr Met Leu Arg Arg Pro Ala Leu Glu Asp Tyr Val Val Leu Met Lys 
    210                 215                 220                 


Arg Gly Thr Ala Ile Thr Phe Pro Lys Asp Ile Asn Met Ile Leu Ser 
225                 230                 235                 240 


Met Met Asp Ile Asn Pro Gly Asp Thr Val Leu Glu Ala Gly Ser Gly 
                245                 250                 255     


Ser Gly Gly Met Ser Leu Phe Leu Ser Lys Ala Val Gly Ser Gln Gly 
            260                 265                 270         


Arg Val Ile Ser Phe Glu Val Arg Lys Asp His His Asp Leu Ala Lys 
        275                 280                 285             


Lys Asn Tyr Lys His Trp Arg Asp Ser Trp Lys Leu Ser His Val Glu 
    290                 295                 300                 


Glu Trp Pro Asp Asn Val Asp Phe Ile His Lys Asp Ile Ser Gly Ala 
305                 310                 315                 320 


Thr Glu Asp Ile Lys Ser Leu Thr Phe Asp Ala Val Ala Leu Asp Met 
                325                 330                 335     


Leu Asn Pro His Val Thr Leu Pro Val Phe Tyr Pro His Leu Lys His 
            340                 345                 350         


Gly Gly Val Cys Ala Val Tyr Val Val Asn Ile Thr Gln Val Ile Glu 
        355                 360                 365             


Leu Leu Asp Gly Ile Arg Thr Cys Glu Leu Ala Leu Ser Cys Glu Lys 
    370                 375                 380                 


Ile Ser Glu Val Ile Val Arg Asp Trp Leu Val Cys Leu Ala Lys Gln 
385                 390                 395                 400 


Lys Asn Gly Ile Leu Ala Gln Lys Val Glu Ser Lys Ile Asn Thr Asp 
                405                 410                 415     


Val Gln Leu Asp Ser Gln Glu Lys Ile Gly Val Lys Gly Glu Leu Phe 
            420                 425                 430         


Gln Glu Asp Asp His Glu Glu Ser His Ser Asp Phe Pro Tyr Gly Ser 
        435                 440                 445             


Phe Pro Tyr Val Ala Arg Pro Val His Trp Gln Pro Gly His Thr Ala 
    450                 455                 460                 


Phe Leu Val Lys Leu Arg Lys Val Lys Pro Gln Leu Asn 
465                 470                 475         


<210>  8
<211>  767
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Met Gly Arg Arg Ser Arg Gly Arg Arg Leu Gln Gln Gln Gln Arg Pro 
1               5                   10                  15      


Glu Asp Ala Glu Asp Gly Ala Glu Gly Gly Gly Lys Arg Gly Glu Ala 
            20                  25                  30          


Gly Trp Glu Gly Gly Tyr Pro Glu Ile Val Lys Glu Asn Lys Leu Phe 
        35                  40                  45              


Glu His Tyr Tyr Gln Glu Leu Lys Ile Val Pro Glu Gly Glu Trp Gly 
    50                  55                  60                  


Gln Phe Met Asp Ala Leu Arg Glu Pro Leu Pro Ala Thr Leu Arg Ile 
65                  70                  75                  80  


Thr Gly Tyr Lys Ser His Ala Lys Glu Ile Leu His Cys Leu Lys Asn 
                85                  90                  95      


Lys Tyr Phe Lys Glu Leu Glu Asp Leu Glu Val Asp Gly Gln Lys Val 
            100                 105                 110         


Glu Val Pro Gln Pro Leu Ser Trp Tyr Pro Glu Glu Leu Ala Trp His 
        115                 120                 125             


Thr Asn Leu Ser Arg Lys Ile Leu Arg Lys Ser Pro His Leu Glu Lys 
    130                 135                 140                 


Phe His Gln Phe Leu Val Ser Glu Thr Glu Ser Gly Asn Ile Ser Arg 
145                 150                 155                 160 


Gln Glu Ala Val Ser Met Ile Pro Pro Leu Leu Leu Asn Val Arg Pro 
                165                 170                 175     


His His Lys Ile Leu Asp Met Cys Ala Ala Pro Gly Ser Lys Thr Thr 
            180                 185                 190         


Gln Leu Ile Glu Met Leu His Ala Asp Met Asn Val Pro Phe Pro Glu 
        195                 200                 205             


Gly Phe Val Ile Ala Asn Asp Val Asp Asn Lys Arg Cys Tyr Leu Leu 
    210                 215                 220                 


Val His Gln Ala Lys Arg Leu Ser Ser Pro Cys Ile Met Val Val Asn 
225                 230                 235                 240 


His Asp Ala Ser Ser Ile Pro Arg Leu Gln Ile Asp Val Asp Gly Arg 
                245                 250                 255     


Lys Glu Ile Leu Phe Tyr Asp Arg Ile Leu Cys Asp Val Pro Cys Ser 
            260                 265                 270         


Gly Asp Gly Thr Met Arg Lys Asn Ile Asp Val Trp Lys Lys Trp Thr 
        275                 280                 285             


Thr Leu Asn Ser Leu Gln Leu His Gly Leu Gln Leu Arg Ile Ala Thr 
    290                 295                 300                 


Arg Gly Ala Glu Gln Leu Ala Glu Gly Gly Arg Met Val Tyr Ser Thr 
305                 310                 315                 320 


Cys Ser Leu Asn Pro Ile Glu Asp Glu Ala Val Ile Ala Ser Leu Leu 
                325                 330                 335     


Glu Lys Ser Glu Gly Ala Leu Glu Leu Ala Asp Val Ser Asn Glu Leu 
            340                 345                 350         


Pro Gly Leu Lys Trp Met Pro Gly Ile Thr Gln Trp Lys Val Met Thr 
        355                 360                 365             


Lys Asp Gly Gln Trp Phe Thr Asp Trp Asp Ala Val Pro His Ser Arg 
    370                 375                 380                 


His Thr Gln Ile Arg Pro Thr Met Phe Pro Pro Lys Asp Pro Glu Lys 
385                 390                 395                 400 


Leu Gln Ala Met His Leu Glu Arg Cys Leu Arg Ile Leu Pro His His 
                405                 410                 415     


Gln Asn Thr Gly Gly Phe Phe Val Ala Val Leu Val Lys Lys Ser Ser 
            420                 425                 430         


Met Pro Trp Asn Lys Arg Gln Pro Lys Leu Gln Gly Lys Ser Ala Glu 
        435                 440                 445             


Thr Arg Glu Ser Thr Gln Leu Ser Pro Ala Asp Leu Thr Glu Gly Lys 
    450                 455                 460                 


Pro Thr Asp Pro Ser Lys Leu Glu Ser Pro Ser Phe Thr Gly Thr Gly 
465                 470                 475                 480 


Asp Thr Glu Ile Ala His Ala Thr Glu Asp Leu Glu Asn Asn Gly Ser 
                485                 490                 495     


Lys Lys Asp Gly Val Cys Gly Pro Pro Pro Ser Lys Lys Met Lys Leu 
            500                 505                 510         


Phe Gly Phe Lys Glu Asp Pro Phe Val Phe Ile Pro Glu Asp Asp Pro 
        515                 520                 525             


Leu Phe Pro Pro Ile Glu Lys Phe Tyr Ala Leu Asp Pro Ser Phe Pro 
    530                 535                 540                 


Arg Met Asn Leu Leu Thr Arg Thr Thr Glu Gly Lys Lys Arg Gln Leu 
545                 550                 555                 560 


Tyr Met Val Ser Lys Glu Leu Arg Asn Val Leu Leu Asn Asn Ser Glu 
                565                 570                 575     


Lys Met Lys Val Ile Asn Thr Gly Ile Lys Val Trp Cys Arg Asn Asn 
            580                 585                 590         


Ser Gly Glu Glu Phe Asp Cys Ala Phe Arg Leu Ala Gln Glu Gly Ile 
        595                 600                 605             


Tyr Thr Leu Tyr Pro Phe Ile Asn Ser Arg Ile Ile Thr Val Ser Met 
    610                 615                 620                 


Glu Asp Val Lys Ile Leu Leu Thr Gln Glu Asn Pro Phe Phe Arg Lys 
625                 630                 635                 640 


Leu Ser Ser Glu Thr Tyr Ser Gln Ala Lys Asp Leu Ala Lys Gly Ser 
                645                 650                 655     


Ile Val Leu Lys Tyr Glu Pro Asp Ser Ala Asn Pro Asp Ala Leu Gln 
            660                 665                 670         


Cys Pro Ile Val Leu Cys Gly Trp Arg Gly Lys Ala Ser Ile Arg Thr 
        675                 680                 685             


Phe Val Pro Lys Asn Glu Arg Leu His Tyr Leu Arg Met Met Gly Leu 
    690                 695                 700                 


Glu Val Leu Gly Glu Lys Lys Lys Glu Gly Val Ile Leu Thr Asn Glu 
705                 710                 715                 720 


Ser Ala Ala Ser Thr Gly Gln Pro Asp Asn Asp Val Thr Glu Gly Gln 
                725                 730                 735     


Arg Ala Gly Glu Pro Asn Ser Pro Asp Ala Glu Glu Ala Asn Ser Pro 
            740                 745                 750         


Asp Val Thr Ala Gly Cys Asp Pro Ala Gly Val His Pro Pro Arg 
        755                 760                 765         


<210>  9
<211>  391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  9

Met Glu Pro Leu Arg Val Leu Glu Leu Tyr Ser Gly Val Gly Gly Met 
1               5                   10                  15      


His His Ala Leu Arg Glu Ser Cys Ile Pro Ala Gln Val Val Ala Ala 
            20                  25                  30          


Ile Asp Val Asn Thr Val Ala Asn Glu Val Tyr Lys Tyr Asn Phe Pro 
        35                  40                  45              


His Thr Gln Leu Leu Ala Lys Thr Ile Glu Gly Ile Thr Leu Glu Glu 
    50                  55                  60                  


Phe Asp Arg Leu Ser Phe Asp Met Ile Leu Met Ser Pro Pro Cys Gln 
65                  70                  75                  80  


Pro Phe Thr Arg Ile Gly Arg Gln Gly Asp Met Thr Asp Ser Arg Thr 
                85                  90                  95      


Asn Ser Phe Leu His Ile Leu Asp Ile Leu Pro Arg Leu Gln Lys Leu 
            100                 105                 110         


Pro Lys Tyr Ile Leu Leu Glu Asn Val Lys Gly Phe Glu Val Ser Ser 
        115                 120                 125             


Thr Arg Asp Leu Leu Ile Gln Thr Ile Glu Asn Cys Gly Phe Gln Tyr 
    130                 135                 140                 


Gln Glu Phe Leu Leu Ser Pro Thr Ser Leu Gly Ile Pro Asn Ser Arg 
145                 150                 155                 160 


Leu Arg Tyr Phe Leu Ile Ala Lys Leu Gln Ser Glu Pro Leu Pro Phe 
                165                 170                 175     


Gln Ala Pro Gly Gln Val Leu Met Glu Phe Pro Lys Ile Glu Ser Val 
            180                 185                 190         


His Pro Gln Lys Tyr Ala Met Asp Val Glu Asn Lys Ile Gln Glu Lys 
        195                 200                 205             


Asn Val Glu Pro Asn Ile Ser Phe Asp Gly Ser Ile Gln Cys Ser Gly 
    210                 215                 220                 


Lys Asp Ala Ile Leu Phe Lys Leu Glu Thr Ala Glu Glu Ile His Arg 
225                 230                 235                 240 


Lys Asn Gln Gln Asp Ser Asp Leu Ser Val Lys Met Leu Lys Asp Phe 
                245                 250                 255     


Leu Glu Asp Asp Thr Asp Val Asn Gln Tyr Leu Leu Pro Pro Lys Ser 
            260                 265                 270         


Leu Leu Arg Tyr Ala Leu Leu Leu Asp Ile Val Gln Pro Thr Cys Arg 
        275                 280                 285             


Arg Ser Val Cys Phe Thr Lys Gly Tyr Gly Ser Tyr Ile Glu Gly Thr 
    290                 295                 300                 


Gly Ser Val Leu Gln Thr Ala Glu Asp Val Gln Val Glu Asn Ile Tyr 
305                 310                 315                 320 


Lys Ser Leu Thr Asn Leu Ser Gln Glu Glu Gln Ile Thr Lys Leu Leu 
                325                 330                 335     


Ile Leu Lys Leu Arg Tyr Phe Thr Pro Lys Glu Ile Ala Asn Leu Leu 
            340                 345                 350         


Gly Phe Pro Pro Glu Phe Gly Phe Pro Glu Lys Ile Thr Val Lys Gln 
        355                 360                 365             


Arg Tyr Arg Leu Leu Gly Asn Ser Leu Asn Val His Val Val Ala Lys 
    370                 375                 380                 


Leu Ile Lys Ile Leu Tyr Glu 
385                 390     


<210>  10
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Met Ser Val Arg Leu Val Leu Ala Lys Gly Arg Glu Lys Ser Leu Leu 
1               5                   10                  15      


Arg Arg His Pro Trp Val Phe Ser Gly Ala Val Ala Arg Met Glu Gly 
            20                  25                  30          


Lys Ala Ser Leu Gly Glu Thr Ile Asp Ile Val Asp His Gln Gly Lys 
        35                  40                  45              


Trp Leu Ala Arg Gly Ala Tyr Ser Pro Ala Ser Gln Ile Arg Ala Arg 
    50                  55                  60                  


Val Trp Thr Phe Asp Pro Ser Glu Ser Ile Asp Ile Ala Phe Phe Ser 
65                  70                  75                  80  


Arg Arg Leu Gln Gln Ala Gln Lys Trp Arg Asp Trp Leu Ala Gln Lys 
                85                  90                  95      


Asp Gly Leu Asp Ser Tyr Arg Leu Ile Ala Gly Glu Ser Asp Gly Leu 
            100                 105                 110         


Pro Gly Ile Thr Ile Asp Arg Phe Gly Asn Phe Leu Val Leu Gln Leu 
        115                 120                 125             


Leu Ser Ala Gly Ala Glu Tyr Gln Arg Ala Ala Leu Ile Ser Ala Leu 
    130                 135                 140                 


Gln Thr Leu Tyr Pro Glu Cys Ser Ile Tyr Asp Arg Ser Asp Val Ala 
145                 150                 155                 160 


Val Arg Lys Lys Glu Gly Met Glu Leu Thr Gln Gly Pro Val Thr Gly 
                165                 170                 175     


Glu Leu Pro Pro Ala Leu Leu Pro Ile Glu Glu His Gly Met Lys Leu 
            180                 185                 190         


Leu Val Asp Ile Gln His Gly His Lys Thr Gly Tyr Tyr Leu Asp Gln 
        195                 200                 205             


Arg Asp Ser Arg Leu Ala Thr Arg Arg Tyr Val Glu Asn Lys Arg Val 
    210                 215                 220                 


Leu Asn Cys Phe Ser Tyr Thr Gly Gly Phe Ala Val Ser Ala Leu Met 
225                 230                 235                 240 


Gly Gly Cys Ser Gln Val Val Ser Val Asp Thr Ser Gln Glu Ala Leu 
                245                 250                 255     


Asp Ile Ala Arg Gln Asn Val Glu Leu Asn Lys Leu Asp Leu Ser Lys 
            260                 265                 270         


Ala Glu Phe Val Arg Asp Asp Val Phe Lys Leu Leu Arg Thr Tyr Arg 
        275                 280                 285             


Asp Arg Gly Glu Lys Phe Asp Val Ile Val Met Asp Pro Pro Lys Phe 
    290                 295                 300                 


Val Glu Asn Lys Ser Gln Leu Met Gly Ala Cys Arg Gly Tyr Lys Asp 
305                 310                 315                 320 


Ile Asn Met Leu Ala Ile Gln Leu Leu Asn Glu Gly Gly Ile Leu Leu 
                325                 330                 335     


Thr Phe Ser Cys Ser Gly Leu Met Thr Ser Asp Leu Phe Gln Lys Ile 
            340                 345                 350         


Ile Ala Asp Ala Ala Ile Asp Ala Gly Arg Asp Val Gln Phe Ile Glu 
        355                 360                 365             


Gln Phe Arg Gln Ala Ala Asp His Pro Val Ile Ala Thr Tyr Pro Glu 
    370                 375                 380                 


Gly Leu Tyr Leu Lys Gly Phe Ala Cys Arg Val Met 
385                 390                 395     


<210>  11
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Met Ala Ala Ala Ser Gly Tyr Thr Asp Leu Arg Glu Lys Leu Lys Ser 
1               5                   10                  15      


Met Thr Ser Arg Asp Asn Tyr Lys Ala Gly Ser Arg Glu Ala Ala Ala 
            20                  25                  30          


Ala Ala Ala Ala Ala Val Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        35                  40                  45              


Glu Pro Tyr Pro Val Ser Gly Ala Lys Arg Lys Tyr Gln Glu Asp Ser 
    50                  55                  60                  


Asp Pro Glu Arg Ser Asp Tyr Glu Glu Gln Gln Leu Gln Lys Glu Glu 
65                  70                  75                  80  


Glu Ala Arg Lys Val Lys Ser Gly Ile Arg Gln Met Arg Leu Phe Ser 
                85                  90                  95      


Gln Asp Glu Cys Ala Lys Ile Glu Ala Arg Ile Asp Glu Val Val Ser 
            100                 105                 110         


Arg Ala Glu Lys Gly Leu Tyr Asn Glu His Thr Val Asp Arg Ala Pro 
        115                 120                 125             


Leu Arg Asn Lys Tyr Phe Phe Gly Glu Gly Tyr Thr Tyr Gly Ala Gln 
    130                 135                 140                 


Leu Gln Lys Arg Gly Pro Gly Gln Glu Arg Leu Tyr Pro Pro Gly Asp 
145                 150                 155                 160 


Val Asp Glu Ile Pro Glu Trp Val His Gln Leu Val Ile Gln Lys Leu 
                165                 170                 175     


Val Glu His Arg Val Ile Pro Glu Gly Phe Val Asn Ser Ala Val Ile 
            180                 185                 190         


Asn Asp Tyr Gln Pro Gly Gly Cys Ile Val Ser His Val Asp Pro Ile 
        195                 200                 205             


His Ile Phe Glu Arg Pro Ile Val Ser Val Ser Phe Phe Ser Asp Ser 
    210                 215                 220                 


Ala Leu Cys Phe Gly Cys Lys Phe Gln Phe Lys Pro Ile Arg Val Ser 
225                 230                 235                 240 


Glu Pro Val Leu Ser Leu Pro Val Arg Arg Gly Ser Val Thr Val Leu 
                245                 250                 255     


Ser Gly Tyr Ala Ala Asp Glu Ile Thr His Cys Ile Arg Pro Gln Asp 
            260                 265                 270         


Ile Lys Glu Arg Arg Ala Val Ile Ile Leu Arg Lys Thr Arg Leu Asp 
        275                 280                 285             


Ala Pro Arg Leu Glu Thr Lys Ser Leu Ser Ser Ser Val Leu Pro Pro 
    290                 295                 300                 


Ser Tyr Ala Ser Asp Arg Leu Ser Gly Asn Asn Arg Asp Pro Ala Leu 
305                 310                 315                 320 


Lys Pro Lys Arg Ser His Arg Lys Ala Asp Pro Asp Ala Ala His Arg 
                325                 330                 335     


Pro Arg Ile Leu Glu Met Asp Lys Glu Glu Asn Arg Arg Ser Val Leu 
            340                 345                 350         


Leu Pro Thr His Arg Arg Arg Gly Ser Phe Ser Ser Glu Asn Tyr Trp 
        355                 360                 365             


Arg Lys Ser Tyr Glu Ser Ser Glu Asp Cys Ser Glu Ala Ala Gly Ser 
    370                 375                 380                 


Pro Ala Arg Lys Val Lys Met Arg Arg His 
385                 390                 


<210>  12
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Met Lys Arg Thr Pro Thr Ala Glu Glu Arg Glu Arg Glu Ala Lys Lys 
1               5                   10                  15      


Leu Arg Leu Leu Glu Glu Leu Glu Asp Thr Trp Leu Pro Tyr Leu Thr 
            20                  25                  30          


Pro Lys Asp Asp Glu Phe Tyr Gln Gln Trp Gln Leu Lys Tyr Pro Lys 
        35                  40                  45              


Leu Ile Leu Arg Glu Ala Ser Ser Val Ser Glu Glu Leu His Lys Glu 
    50                  55                  60                  


Val Gln Glu Ala Phe Leu Thr Leu His Lys His Gly Cys Leu Phe Arg 
65                  70                  75                  80  


Asp Leu Val Arg Ile Gln Gly Lys Asp Leu Leu Thr Pro Val Ser Arg 
                85                  90                  95      


Ile Leu Ile Gly Asn Pro Gly Cys Thr Tyr Lys Tyr Leu Asn Thr Arg 
            100                 105                 110         


Leu Phe Thr Val Pro Trp Pro Val Lys Gly Ser Asn Ile Lys His Thr 
        115                 120                 125             


Glu Ala Glu Ile Ala Ala Ala Cys Glu Thr Phe Leu Lys Leu Asn Asp 
    130                 135                 140                 


Tyr Leu Gln Ile Glu Thr Ile Gln Ala Leu Glu Glu Leu Ala Ala Lys 
145                 150                 155                 160 


Glu Lys Ala Asn Glu Asp Ala Val Pro Leu Cys Met Ser Ala Asp Phe 
                165                 170                 175     


Pro Arg Val Gly Met Gly Ser Ser Tyr Asn Gly Gln Asp Glu Val Asp 
            180                 185                 190         


Ile Lys Ser Arg Ala Ala Tyr Asn Val Thr Leu Leu Asn Phe Met Asp 
        195                 200                 205             


Pro Gln Lys Met Pro Tyr Leu Lys Glu Glu Pro Tyr Phe Gly Met Gly 
    210                 215                 220                 


Lys Met Ala Val Ser Trp His His Asp Glu Asn Leu Val Asp Arg Ser 
225                 230                 235                 240 


Ala Val Ala Val Tyr Ser Tyr Ser Cys Glu Gly Pro Glu Glu Glu Ser 
                245                 250                 255     


Glu Asp Asp Ser His Leu Glu Gly Arg Asp Pro Asp Ile Trp His Val 
            260                 265                 270         


Gly Phe Lys Ile Ser Trp Asp Ile Glu Thr Pro Gly Leu Ala Ile Pro 
        275                 280                 285             


Leu His Gln Gly Asp Cys Tyr Phe Met Leu Asp Asp Leu Asn Ala Thr 
    290                 295                 300                 


His Gln His Cys Val Leu Ala Gly Ser Gln Pro Arg Phe Ser Ser Thr 
305                 310                 315                 320 


His Arg Val Ala Glu Cys Ser Thr Gly Thr Leu Asp Tyr Ile Leu Gln 
                325                 330                 335     


Arg Cys Gln Leu Ala Leu Gln Asn Val Cys Asp Asp Val Asp Asn Asp 
            340                 345                 350         


Asp Val Ser Leu Lys Ser Phe Glu Pro Ala Val Leu Lys Gln Gly Glu 
        355                 360                 365             


Glu Ile His Asn Glu Val Glu Phe Glu Trp Leu Arg Gln Phe Trp Phe 
    370                 375                 380                 


Gln Gly Asn Arg Tyr Arg Lys Cys Thr Asp Trp Trp Cys Gln Pro Met 
385                 390                 395                 400 


Ala Gln Leu Glu Ala Leu Trp Lys Lys Met Glu Gly Val Thr Asn Ala 
                405                 410                 415     


Val Leu His Glu Val Lys Arg Glu Gly Leu Pro Val Glu Gln Arg Asn 
            420                 425                 430         


Glu Ile Leu Thr Ala Ile Leu Ala Ser Leu Thr Ala Arg Gln Asn Leu 
        435                 440                 445             


Arg Arg Glu Trp His Ala Arg Cys Gln Ser Arg Ile Ala Arg Thr Leu 
    450                 455                 460                 


Pro Ala Asp Gln Lys Pro Glu Cys Arg Pro Tyr Trp Glu Lys Asp Asp 
465                 470                 475                 480 


Ala Ser Met Pro Leu Pro Phe Asp Leu Thr Asp Ile Val Ser Glu Leu 
                485                 490                 495     


Arg Gly Gln Leu Leu Glu Ala Lys Pro 
            500                 505 


<210>  13
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<222>  (6)..(150)
<223>  may be absent

<400>  13

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser 
145                 150 


<210>  14
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<222>  (6)..(150)
<223>  may be absent

<400>  14

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu 
1               5                   10                  15      


Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala 
            20                  25                  30          


Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala 
        35                  40                  45              


Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala 
    50                  55                  60                  


Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
65                  70                  75                  80  


Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu 
                85                  90                  95      


Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala 
            100                 105                 110         


Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala 
        115                 120                 125             


Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala 
    130                 135                 140                 


Lys Glu Ala Ala Ala Lys 
145                 150 


<210>  15
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<222>  (5)..(120)
<223>  may be absent

<400>  15

Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
1               5                   10                  15      


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
            20                  25                  30          


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
        35                  40                  45              


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
    50                  55                  60                  


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
65                  70                  75                  80  


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
                85                  90                  95      


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
            100                 105                 110         


Ser Gly Gly Ser Ser Gly Gly Ser 
        115                 120 


<210>  16
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  16

Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
1               5                   10                  15      


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  17

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  18
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  18

Met Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr Gln Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys 
            20                  25                  30  


<210>  19
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  19

Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys Arg 
1               5                   10                  15      


Lys Val 
        


<210>  20
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  20

Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Pro Lys Lys Lys Arg Lys 
1               5                   10                  15      


Val 
    


<210>  21
<211>  16
<212>  PRT
<213>  Xenopus nucleoplasmin


<220>
<221>  misc_feature
<222>  (3)..(12)
<223>  Xaa can be any naturally occurring amino acid

<400>  21

Lys Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Lys Lys Leu 
1               5                   10                  15      


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  22

Ser Gly Gly Ser Ser Gly Gly Ser 
1               5               


<210>  23
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  23

Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr 
1               5                   10                  15      


Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser 
            20                  25                  30          


<210>  24
<211>  1320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  24

Met Asn Ile Pro Ala Leu Val Glu Asn Gln Lys Lys Tyr Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ala Met Leu Asn Ala Gln Thr Val Leu Asp His Ile 
            20                  25                  30          


Gln Lys Val Ala Asp Ile Glu Gly Glu Gln Asn Glu Asn Asn Glu Asn 
        35                  40                  45              


Leu Trp Phe His Pro Val Met Ser His Leu Tyr Asn Ala Lys Asn Gly 
    50                  55                  60                  


Tyr Asp Lys Gln Pro Glu Lys Thr Met Phe Ile Ile Glu Arg Leu Gln 
65                  70                  75                  80  


Ser Tyr Phe Pro Phe Leu Lys Ile Met Ala Glu Asn Gln Arg Glu Tyr 
                85                  90                  95      


Ser Asn Gly Lys Tyr Lys Gln Asn Arg Val Glu Val Asn Ser Asn Asp 
            100                 105                 110         


Ile Phe Glu Val Leu Lys Arg Ala Phe Gly Val Leu Lys Met Tyr Arg 
        115                 120                 125             


Asp Leu Thr Asn Ala Tyr Lys Thr Tyr Glu Glu Lys Leu Asn Asp Gly 
    130                 135                 140                 


Cys Glu Phe Leu Thr Ser Thr Glu Gln Pro Leu Ser Gly Met Ile Asn 
145                 150                 155                 160 


Asn Tyr Tyr Thr Val Ala Leu Arg Asn Met Asn Glu Arg Tyr Gly Tyr 
                165                 170                 175     


Lys Thr Glu Asp Leu Ala Phe Ile Gln Asp Lys Arg Phe Lys Phe Val 
            180                 185                 190         


Lys Asp Ala Tyr Gly Lys Lys Lys Ser Gln Val Asn Thr Gly Phe Phe 
        195                 200                 205             


Leu Ser Leu Gln Asp Tyr Asn Gly Asp Thr Gln Lys Lys Leu His Leu 
    210                 215                 220                 


Ser Gly Val Gly Ile Ala Leu Leu Ile Cys Leu Phe Leu Asp Lys Gln 
225                 230                 235                 240 


Tyr Ile Asn Ile Phe Leu Ser Arg Leu Pro Ile Phe Ser Ser Tyr Asn 
                245                 250                 255     


Ala Gln Ser Glu Glu Arg Arg Ile Ile Ile Arg Ser Phe Gly Ile Asn 
            260                 265                 270         


Ser Ile Lys Leu Pro Lys Asp Arg Ile His Ser Glu Lys Ser Asn Lys 
        275                 280                 285             


Ser Val Ala Met Asp Met Leu Asn Glu Val Lys Arg Cys Pro Asp Glu 
    290                 295                 300                 


Leu Phe Thr Thr Leu Ser Ala Glu Lys Gln Ser Arg Phe Arg Ile Ile 
305                 310                 315                 320 


Ser Asp Asp His Asn Glu Val Leu Met Lys Arg Ser Ser Asp Arg Phe 
                325                 330                 335     


Val Pro Leu Leu Leu Gln Tyr Ile Asp Tyr Gly Lys Leu Phe Asp His 
            340                 345                 350         


Ile Arg Phe His Val Asn Met Gly Lys Leu Arg Tyr Leu Leu Lys Ala 
        355                 360                 365             


Asp Lys Thr Cys Ile Asp Gly Gln Thr Arg Val Arg Val Ile Glu Gln 
    370                 375                 380                 


Pro Leu Asn Gly Phe Gly Arg Leu Glu Glu Ala Glu Thr Met Arg Lys 
385                 390                 395                 400 


Gln Glu Asn Gly Thr Phe Gly Asn Ser Gly Ile Arg Ile Arg Asp Phe 
                405                 410                 415     


Glu Asn Met Lys Arg Asp Asp Ala Asn Pro Ala Asn Tyr Pro Tyr Ile 
            420                 425                 430         


Val Asp Thr Tyr Thr His Tyr Ile Leu Glu Asn Asn Lys Val Glu Met 
        435                 440                 445             


Phe Ile Asn Asp Lys Glu Asp Ser Ala Pro Leu Leu Pro Val Ile Glu 
    450                 455                 460                 


Asp Asp Arg Tyr Val Val Lys Thr Ile Pro Ser Cys Arg Met Ser Thr 
465                 470                 475                 480 


Leu Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Phe Gly Ser Lys 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Val Asp Val His Asn Arg Tyr Lys Arg Leu 
            500                 505                 510         


Phe Gln Ala Met Gln Lys Glu Glu Val Thr Ala Glu Asn Ile Ala Ser 
        515                 520                 525             


Phe Gly Ile Ala Glu Ser Asp Leu Pro Gln Lys Ile Leu Asp Leu Ile 
    530                 535                 540                 


Ser Gly Asn Ala His Gly Lys Asp Val Asp Ala Phe Ile Arg Leu Thr 
545                 550                 555                 560 


Val Asp Asp Met Leu Thr Asp Thr Glu Arg Arg Ile Lys Arg Phe Lys 
                565                 570                 575     


Asp Asp Arg Lys Ser Ile Arg Ser Ala Asp Asn Lys Met Gly Lys Arg 
            580                 585                 590         


Gly Phe Lys Gln Ile Ser Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Leu Phe Gln Pro Ser Val Asn Asp Gly Glu Asn Lys Ile 
    610                 615                 620                 


Thr Gly Leu Asn Tyr Arg Ile Met Gln Ser Ala Ile Ala Val Tyr Asp 
625                 630                 635                 640 


Ser Gly Asp Asp Tyr Glu Ala Lys Gln Gln Phe Lys Leu Met Phe Glu 
                645                 650                 655     


Lys Ala Arg Leu Ile Gly Lys Gly Thr Thr Glu Pro His Pro Phe Leu 
            660                 665                 670         


Tyr Lys Val Phe Ala Arg Ser Ile Pro Ala Asn Ala Val Glu Phe Tyr 
        675                 680                 685             


Glu Arg Tyr Leu Ile Glu Arg Lys Phe Tyr Leu Thr Gly Leu Ser Asn 
    690                 695                 700                 


Glu Ile Lys Lys Gly Asn Arg Val Asp Val Pro Phe Ile Arg Arg Asp 
705                 710                 715                 720 


Gln Asn Lys Trp Lys Thr Pro Ala Met Lys Thr Leu Gly Arg Ile Tyr 
                725                 730                 735     


Ser Glu Asp Leu Pro Val Glu Leu Pro Arg Gln Met Phe Asp Asn Glu 
            740                 745                 750         


Ile Lys Ser His Leu Lys Ser Leu Pro Gln Met Glu Gly Ile Asp Phe 
        755                 760                 765             


Asn Asn Ala Asn Val Thr Tyr Leu Ile Ala Glu Tyr Met Lys Arg Val 
    770                 775                 780                 


Leu Asp Asp Asp Phe Gln Thr Phe Tyr Gln Trp Asn Arg Asn Tyr Arg 
785                 790                 795                 800 


Tyr Met Asp Met Leu Lys Gly Glu Tyr Asp Arg Lys Gly Ser Leu Gln 
                805                 810                 815     


His Cys Phe Thr Ser Val Glu Glu Arg Glu Gly Leu Trp Lys Glu Arg 
            820                 825                 830         


Ala Ser Arg Thr Glu Arg Tyr Arg Lys Gln Ala Ser Asn Lys Ile Arg 
        835                 840                 845             


Ser Asn Arg Gln Met Arg Asn Ala Ser Ser Glu Glu Ile Glu Thr Ile 
    850                 855                 860                 


Leu Asp Lys Arg Leu Ser Asn Ser Arg Asn Glu Tyr Gln Lys Ser Glu 
865                 870                 875                 880 


Lys Val Ile Arg Arg Tyr Arg Val Gln Asp Ala Leu Leu Phe Leu Leu 
                885                 890                 895     


Ala Lys Lys Thr Leu Thr Glu Leu Ala Asp Phe Asp Gly Glu Arg Phe 
            900                 905                 910         


Lys Leu Lys Glu Ile Met Pro Asp Ala Glu Lys Gly Ile Leu Ser Glu 
        915                 920                 925             


Ile Met Pro Met Ser Phe Thr Phe Glu Lys Gly Gly Lys Lys Tyr Thr 
    930                 935                 940                 


Ile Thr Ser Glu Gly Met Lys Leu Lys Asn Tyr Gly Asp Phe Phe Val 
945                 950                 955                 960 


Leu Ala Ser Asp Lys Arg Ile Gly Asn Leu Leu Glu Leu Val Gly Ser 
                965                 970                 975     


Asp Ile Val Ser Lys Glu Asp Gly Ser Leu Gln Leu Pro Pro Leu Glu 
            980                 985                 990         


Arg Leu Thr Leu Ser Gly Ser Glu  Thr Pro Gly Thr Ser  Glu Ser Ala 
        995                 1000                 1005             


Thr Pro  Glu Ser Gln Glu Phe  Cys Asp Tyr Gly Thr  Lys Glu Glu 
    1010                 1015                 1020             


Cys Met  Lys Ala Ser Asp Ala  Asp Arg Pro Cys Arg  Lys Leu His 
    1025                 1030                 1035             


Phe Arg  Arg Ile Ile Asn Lys  His Thr Asp Glu Ser  Leu Gly Asp 
    1040                 1045                 1050             


Cys Ser  Phe Leu Asn Thr Cys  Phe His Met Asp Thr  Cys Lys Tyr 
    1055                 1060                 1065             


Val His  Tyr Glu Ile Asp Ala  Cys Met Asp Ser Glu  Ala Pro Gly 
    1070                 1075                 1080             


Ser Lys  Asp His Thr Pro Ser  Gln Glu Leu Ala Leu  Thr Gln Ser 
    1085                 1090                 1095             


Val Gly  Gly Asp Ser Ser Ala  Asp Arg Leu Phe Pro  Pro Gln Trp 
    1100                 1105                 1110             


Ile Cys  Cys Asp Ile Arg Tyr  Leu Asp Val Ser Ile  Leu Gly Lys 
    1115                 1120                 1125             


Phe Ala  Val Val Met Ala Asp  Pro Pro Trp Asp Ile  His Met Glu 
    1130                 1135                 1140             


Leu Pro  Tyr Gly Thr Leu Thr  Asp Asp Glu Met Arg  Arg Leu Asn 
    1145                 1150                 1155             


Ile Pro  Val Leu Gln Asp Asp  Gly Phe Leu Phe Leu  Trp Val Thr 
    1160                 1165                 1170             


Gly Arg  Ala Met Glu Leu Gly  Arg Glu Cys Leu Asn  Leu Trp Gly 
    1175                 1180                 1185             


Tyr Glu  Arg Val Asp Glu Ile  Ile Trp Val Lys Thr  Asn Gln Leu 
    1190                 1195                 1200             


Gln Arg  Ile Ile Arg Thr Gly  Arg Thr Gly His Trp  Leu Asn His 
    1205                 1210                 1215             


Gly Lys  Glu His Cys Leu Val  Gly Val Lys Gly Asn  Pro Gln Gly 
    1220                 1225                 1230             


Phe Asn  Gln Gly Leu Asp Cys  Asp Val Ile Val Ala  Glu Val Arg 
    1235                 1240                 1245             


Ser Thr  Ser His Lys Pro Asp  Glu Ile Tyr Gly Met  Ile Glu Arg 
    1250                 1255                 1260             


Leu Ser  Pro Gly Thr Arg Lys  Ile Glu Leu Phe Gly  Arg Pro His 
    1265                 1270                 1275             


Asn Val  Gln Pro Asn Trp Ile  Thr Leu Gly Asn Gln  Leu Asp Gly 
    1280                 1285                 1290             


Ile His  Leu Leu Asp Pro Asp  Val Val Ala Arg Phe  Lys Gln Arg 
    1295                 1300                 1305             


Tyr Pro  Asp Gly Ile Ile Ser  Lys Pro Lys Asn Leu  
    1310                 1315                 1320 


<210>  25
<211>  1344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  25

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Asn Ile Pro Ala Leu Val Glu Asn Gln Lys Lys Tyr Phe 
            20                  25                  30          


Gly Thr Tyr Ser Val Met Ala Met Leu Asn Ala Gln Thr Val Leu Asp 
        35                  40                  45              


His Ile Gln Lys Val Ala Asp Ile Glu Gly Glu Gln Asn Glu Asn Asn 
    50                  55                  60                  


Glu Asn Leu Trp Phe His Pro Val Met Ser His Leu Tyr Asn Ala Lys 
65                  70                  75                  80  


Asn Gly Tyr Asp Lys Gln Pro Glu Lys Thr Met Phe Ile Ile Glu Arg 
                85                  90                  95      


Leu Gln Ser Tyr Phe Pro Phe Leu Lys Ile Met Ala Glu Asn Gln Arg 
            100                 105                 110         


Glu Tyr Ser Asn Gly Lys Tyr Lys Gln Asn Arg Val Glu Val Asn Ser 
        115                 120                 125             


Asn Asp Ile Phe Glu Val Leu Lys Arg Ala Phe Gly Val Leu Lys Met 
    130                 135                 140                 


Tyr Arg Asp Leu Thr Asn Ala Tyr Lys Thr Tyr Glu Glu Lys Leu Asn 
145                 150                 155                 160 


Asp Gly Cys Glu Phe Leu Thr Ser Thr Glu Gln Pro Leu Ser Gly Met 
                165                 170                 175     


Ile Asn Asn Tyr Tyr Thr Val Ala Leu Arg Asn Met Asn Glu Arg Tyr 
            180                 185                 190         


Gly Tyr Lys Thr Glu Asp Leu Ala Phe Ile Gln Asp Lys Arg Phe Lys 
        195                 200                 205             


Phe Val Lys Asp Ala Tyr Gly Lys Lys Lys Ser Gln Val Asn Thr Gly 
    210                 215                 220                 


Phe Phe Leu Ser Leu Gln Asp Tyr Asn Gly Asp Thr Gln Lys Lys Leu 
225                 230                 235                 240 


His Leu Ser Gly Val Gly Ile Ala Leu Leu Ile Cys Leu Phe Leu Asp 
                245                 250                 255     


Lys Gln Tyr Ile Asn Ile Phe Leu Ser Arg Leu Pro Ile Phe Ser Ser 
            260                 265                 270         


Tyr Asn Ala Gln Ser Glu Glu Arg Arg Ile Ile Ile Arg Ser Phe Gly 
        275                 280                 285             


Ile Asn Ser Ile Lys Leu Pro Lys Asp Arg Ile His Ser Glu Lys Ser 
    290                 295                 300                 


Asn Lys Ser Val Ala Met Asp Met Leu Asn Glu Val Lys Arg Cys Pro 
305                 310                 315                 320 


Asp Glu Leu Phe Thr Thr Leu Ser Ala Glu Lys Gln Ser Arg Phe Arg 
                325                 330                 335     


Ile Ile Ser Asp Asp His Asn Glu Val Leu Met Lys Arg Ser Ser Asp 
            340                 345                 350         


Arg Phe Val Pro Leu Leu Leu Gln Tyr Ile Asp Tyr Gly Lys Leu Phe 
        355                 360                 365             


Asp His Ile Arg Phe His Val Asn Met Gly Lys Leu Arg Tyr Leu Leu 
    370                 375                 380                 


Lys Ala Asp Lys Thr Cys Ile Asp Gly Gln Thr Arg Val Arg Val Ile 
385                 390                 395                 400 


Glu Gln Pro Leu Asn Gly Phe Gly Arg Leu Glu Glu Ala Glu Thr Met 
                405                 410                 415     


Arg Lys Gln Glu Asn Gly Thr Phe Gly Asn Ser Gly Ile Arg Ile Arg 
            420                 425                 430         


Asp Phe Glu Asn Met Lys Arg Asp Asp Ala Asn Pro Ala Asn Tyr Pro 
        435                 440                 445             


Tyr Ile Val Asp Thr Tyr Thr His Tyr Ile Leu Glu Asn Asn Lys Val 
    450                 455                 460                 


Glu Met Phe Ile Asn Asp Lys Glu Asp Ser Ala Pro Leu Leu Pro Val 
465                 470                 475                 480 


Ile Glu Asp Asp Arg Tyr Val Val Lys Thr Ile Pro Ser Cys Arg Met 
                485                 490                 495     


Ser Thr Leu Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Phe Gly 
            500                 505                 510         


Ser Lys Lys Thr Glu Lys Leu Ile Val Asp Val His Asn Arg Tyr Lys 
        515                 520                 525             


Arg Leu Phe Gln Ala Met Gln Lys Glu Glu Val Thr Ala Glu Asn Ile 
    530                 535                 540                 


Ala Ser Phe Gly Ile Ala Glu Ser Asp Leu Pro Gln Lys Ile Leu Asp 
545                 550                 555                 560 


Leu Ile Ser Gly Asn Ala His Gly Lys Asp Val Asp Ala Phe Ile Arg 
                565                 570                 575     


Leu Thr Val Asp Asp Met Leu Thr Asp Thr Glu Arg Arg Ile Lys Arg 
            580                 585                 590         


Phe Lys Asp Asp Arg Lys Ser Ile Arg Ser Ala Asp Asn Lys Met Gly 
        595                 600                 605             


Lys Arg Gly Phe Lys Gln Ile Ser Thr Gly Lys Leu Ala Asp Phe Leu 
    610                 615                 620                 


Ala Lys Asp Ile Val Leu Phe Gln Pro Ser Val Asn Asp Gly Glu Asn 
625                 630                 635                 640 


Lys Ile Thr Gly Leu Asn Tyr Arg Ile Met Gln Ser Ala Ile Ala Val 
                645                 650                 655     


Tyr Asp Ser Gly Asp Asp Tyr Glu Ala Lys Gln Gln Phe Lys Leu Met 
            660                 665                 670         


Phe Glu Lys Ala Arg Leu Ile Gly Lys Gly Thr Thr Glu Pro His Pro 
        675                 680                 685             


Phe Leu Tyr Lys Val Phe Ala Arg Ser Ile Pro Ala Asn Ala Val Glu 
    690                 695                 700                 


Phe Tyr Glu Arg Tyr Leu Ile Glu Arg Lys Phe Tyr Leu Thr Gly Leu 
705                 710                 715                 720 


Ser Asn Glu Ile Lys Lys Gly Asn Arg Val Asp Val Pro Phe Ile Arg 
                725                 730                 735     


Arg Asp Gln Asn Lys Trp Lys Thr Pro Ala Met Lys Thr Leu Gly Arg 
            740                 745                 750         


Ile Tyr Ser Glu Asp Leu Pro Val Glu Leu Pro Arg Gln Met Phe Asp 
        755                 760                 765             


Asn Glu Ile Lys Ser His Leu Lys Ser Leu Pro Gln Met Glu Gly Ile 
    770                 775                 780                 


Asp Phe Asn Asn Ala Asn Val Thr Tyr Leu Ile Ala Glu Tyr Met Lys 
785                 790                 795                 800 


Arg Val Leu Asp Asp Asp Phe Gln Thr Phe Tyr Gln Trp Asn Arg Asn 
                805                 810                 815     


Tyr Arg Tyr Met Asp Met Leu Lys Gly Glu Tyr Asp Arg Lys Gly Ser 
            820                 825                 830         


Leu Gln His Cys Phe Thr Ser Val Glu Glu Arg Glu Gly Leu Trp Lys 
        835                 840                 845             


Glu Arg Ala Ser Arg Thr Glu Arg Tyr Arg Lys Gln Ala Ser Asn Lys 
    850                 855                 860                 


Ile Arg Ser Asn Arg Gln Met Arg Asn Ala Ser Ser Glu Glu Ile Glu 
865                 870                 875                 880 


Thr Ile Leu Asp Lys Arg Leu Ser Asn Ser Arg Asn Glu Tyr Gln Lys 
                885                 890                 895     


Ser Glu Lys Val Ile Arg Arg Tyr Arg Val Gln Asp Ala Leu Leu Phe 
            900                 905                 910         


Leu Leu Ala Lys Lys Thr Leu Thr Glu Leu Ala Asp Phe Asp Gly Glu 
        915                 920                 925             


Arg Phe Lys Leu Lys Glu Ile Met Pro Asp Ala Glu Lys Gly Ile Leu 
    930                 935                 940                 


Ser Glu Ile Met Pro Met Ser Phe Thr Phe Glu Lys Gly Gly Lys Lys 
945                 950                 955                 960 


Tyr Thr Ile Thr Ser Glu Gly Met Lys Leu Lys Asn Tyr Gly Asp Phe 
                965                 970                 975     


Phe Val Leu Ala Ser Asp Lys Arg Ile Gly Asn Leu Leu Glu Leu Val 
            980                 985                 990         


Gly Ser Asp Ile Val Ser Lys Glu  Asp Gly Ser Lys Arg  Thr Ala Asp 
        995                 1000                 1005             


Gly Ser  Glu Phe Glu Pro Lys  Lys Lys Arg Lys Val  Ser Gly Ser 
    1010                 1015                 1020             


Glu Thr  Pro Gly Thr Ser Glu  Ser Ala Thr Pro Glu  Ser Gln Glu 
    1025                 1030                 1035             


Phe Cys  Asp Tyr Gly Thr Lys  Glu Glu Cys Met Lys  Ala Ser Asp 
    1040                 1045                 1050             


Ala Asp  Arg Pro Cys Arg Lys  Leu His Phe Arg Arg  Ile Ile Asn 
    1055                 1060                 1065             


Lys His  Thr Asp Glu Ser Leu  Gly Asp Cys Ser Phe  Leu Asn Thr 
    1070                 1075                 1080             


Cys Phe  His Met Asp Thr Cys  Lys Tyr Val His Tyr  Glu Ile Asp 
    1085                 1090                 1095             


Ala Cys  Met Asp Ser Glu Ala  Pro Gly Ser Lys Asp  His Thr Pro 
    1100                 1105                 1110             


Ser Gln  Glu Leu Ala Leu Thr  Gln Ser Val Gly Gly  Asp Ser Ser 
    1115                 1120                 1125             


Ala Asp  Arg Leu Phe Pro Pro  Gln Trp Ile Cys Cys  Asp Ile Arg 
    1130                 1135                 1140             


Tyr Leu  Asp Val Ser Ile Leu  Gly Lys Phe Ala Val  Val Met Ala 
    1145                 1150                 1155             


Asp Pro  Pro Trp Asp Ile His  Met Glu Leu Pro Tyr  Gly Thr Leu 
    1160                 1165                 1170             


Thr Asp  Asp Glu Met Arg Arg  Leu Asn Ile Pro Val  Leu Gln Asp 
    1175                 1180                 1185             


Asp Gly  Phe Leu Phe Leu Trp  Val Thr Gly Arg Ala  Met Glu Leu 
    1190                 1195                 1200             


Gly Arg  Glu Cys Leu Asn Leu  Trp Gly Tyr Glu Arg  Val Asp Glu 
    1205                 1210                 1215             


Ile Ile  Trp Val Lys Thr Asn  Gln Leu Gln Arg Ile  Ile Arg Thr 
    1220                 1225                 1230             


Gly Arg  Thr Gly His Trp Leu  Asn His Gly Lys Glu  His Cys Leu 
    1235                 1240                 1245             


Val Gly  Val Lys Gly Asn Pro  Gln Gly Phe Asn Gln  Gly Leu Asp 
    1250                 1255                 1260             


Cys Asp  Val Ile Val Ala Glu  Val Arg Ser Thr Ser  His Lys Pro 
    1265                 1270                 1275             


Asp Glu  Ile Tyr Gly Met Ile  Glu Arg Leu Ser Pro  Gly Thr Arg 
    1280                 1285                 1290             


Lys Ile  Glu Leu Phe Gly Arg  Pro His Asn Val Gln  Pro Asn Trp 
    1295                 1300                 1305             


Ile Thr  Leu Gly Asn Gln Leu  Asp Gly Ile His Leu  Leu Asp Pro 
    1310                 1315                 1320             


Asp Val  Val Ala Arg Phe Lys  Gln Arg Tyr Pro Asp  Gly Ile Ile 
    1325                 1330                 1335             


Ser Lys  Pro Lys Asn Leu 
    1340                 


<210>  26
<211>  1626
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  26

Met Asn Ile Pro Ala Leu Val Glu Asn Gln Lys Lys Tyr Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ala Met Leu Asn Ala Gln Thr Val Leu Asp His Ile 
            20                  25                  30          


Gln Lys Val Ala Asp Ile Glu Gly Glu Gln Asn Glu Asn Asn Glu Asn 
        35                  40                  45              


Leu Trp Phe His Pro Val Met Ser His Leu Tyr Asn Ala Lys Asn Gly 
    50                  55                  60                  


Tyr Asp Lys Gln Pro Glu Lys Thr Met Phe Ile Ile Glu Arg Leu Gln 
65                  70                  75                  80  


Ser Tyr Phe Pro Phe Leu Lys Ile Met Ala Glu Asn Gln Arg Glu Tyr 
                85                  90                  95      


Ser Asn Gly Lys Tyr Lys Gln Asn Arg Val Glu Val Asn Ser Asn Asp 
            100                 105                 110         


Ile Phe Glu Val Leu Lys Arg Ala Phe Gly Val Leu Lys Met Tyr Arg 
        115                 120                 125             


Asp Leu Thr Asn Ala Tyr Lys Thr Tyr Glu Glu Lys Leu Asn Asp Gly 
    130                 135                 140                 


Cys Glu Phe Leu Thr Ser Thr Glu Gln Pro Leu Ser Gly Met Ile Asn 
145                 150                 155                 160 


Asn Tyr Tyr Thr Val Ala Leu Arg Asn Met Asn Glu Arg Tyr Gly Tyr 
                165                 170                 175     


Lys Thr Glu Asp Leu Ala Phe Ile Gln Asp Lys Arg Phe Lys Phe Val 
            180                 185                 190         


Lys Asp Ala Tyr Gly Lys Lys Lys Ser Gln Val Asn Thr Gly Phe Phe 
        195                 200                 205             


Leu Ser Leu Gln Asp Tyr Asn Gly Asp Thr Gln Lys Lys Leu His Leu 
    210                 215                 220                 


Ser Gly Val Gly Ile Ala Leu Leu Ile Cys Leu Phe Leu Asp Lys Gln 
225                 230                 235                 240 


Tyr Ile Asn Ile Phe Leu Ser Arg Leu Pro Ile Phe Ser Ser Tyr Asn 
                245                 250                 255     


Ala Gln Ser Glu Glu Arg Arg Ile Ile Ile Arg Ser Phe Gly Ile Asn 
            260                 265                 270         


Ser Ile Lys Leu Pro Lys Asp Arg Ile His Ser Glu Lys Ser Asn Lys 
        275                 280                 285             


Ser Val Ala Met Asp Met Leu Asn Glu Val Lys Arg Cys Pro Asp Glu 
    290                 295                 300                 


Leu Phe Thr Thr Leu Ser Ala Glu Lys Gln Ser Arg Phe Arg Ile Ile 
305                 310                 315                 320 


Ser Asp Asp His Asn Glu Val Leu Met Lys Arg Ser Ser Asp Arg Phe 
                325                 330                 335     


Val Pro Leu Leu Leu Gln Tyr Ile Asp Tyr Gly Lys Leu Phe Asp His 
            340                 345                 350         


Ile Arg Phe His Val Asn Met Gly Lys Leu Arg Tyr Leu Leu Lys Ala 
        355                 360                 365             


Asp Lys Thr Cys Ile Asp Gly Gln Thr Arg Val Arg Val Ile Glu Gln 
    370                 375                 380                 


Pro Leu Asn Gly Phe Gly Arg Leu Glu Glu Ala Glu Thr Met Arg Lys 
385                 390                 395                 400 


Gln Glu Asn Gly Thr Phe Gly Asn Ser Gly Ile Arg Ile Arg Asp Phe 
                405                 410                 415     


Glu Asn Met Lys Arg Asp Asp Ala Asn Pro Ala Asn Tyr Pro Tyr Ile 
            420                 425                 430         


Val Asp Thr Tyr Thr His Tyr Ile Leu Glu Asn Asn Lys Val Glu Met 
        435                 440                 445             


Phe Ile Asn Asp Lys Glu Asp Ser Ala Pro Leu Leu Pro Val Ile Glu 
    450                 455                 460                 


Asp Asp Arg Tyr Val Val Lys Thr Ile Pro Ser Cys Arg Met Ser Thr 
465                 470                 475                 480 


Leu Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Phe Gly Ser Lys 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Val Asp Val His Asn Arg Tyr Lys Arg Leu 
            500                 505                 510         


Phe Gln Ala Met Gln Lys Glu Glu Val Thr Ala Glu Asn Ile Ala Ser 
        515                 520                 525             


Phe Gly Ile Ala Glu Ser Asp Leu Pro Gln Lys Ile Leu Asp Leu Ile 
    530                 535                 540                 


Ser Gly Asn Ala His Gly Lys Asp Val Asp Ala Phe Ile Arg Leu Thr 
545                 550                 555                 560 


Val Asp Asp Met Leu Thr Asp Thr Glu Arg Arg Ile Lys Arg Phe Lys 
                565                 570                 575     


Asp Asp Arg Lys Ser Ile Arg Ser Ala Asp Asn Lys Met Gly Lys Arg 
            580                 585                 590         


Gly Phe Lys Gln Ile Ser Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Leu Phe Gln Pro Ser Val Asn Asp Gly Glu Asn Lys Ile 
    610                 615                 620                 


Thr Gly Leu Asn Tyr Arg Ile Met Gln Ser Ala Ile Ala Val Tyr Asp 
625                 630                 635                 640 


Ser Gly Asp Asp Tyr Glu Ala Lys Gln Gln Phe Lys Leu Met Phe Glu 
                645                 650                 655     


Lys Ala Arg Leu Ile Gly Lys Gly Thr Thr Glu Pro His Pro Phe Leu 
            660                 665                 670         


Tyr Lys Val Phe Ala Arg Ser Ile Pro Ala Asn Ala Val Glu Phe Tyr 
        675                 680                 685             


Glu Arg Tyr Leu Ile Glu Arg Lys Phe Tyr Leu Thr Gly Leu Ser Asn 
    690                 695                 700                 


Glu Ile Lys Lys Gly Asn Arg Val Asp Val Pro Phe Ile Arg Arg Asp 
705                 710                 715                 720 


Gln Asn Lys Trp Lys Thr Pro Ala Met Lys Thr Leu Gly Arg Ile Tyr 
                725                 730                 735     


Ser Glu Asp Leu Pro Val Glu Leu Pro Arg Gln Met Phe Asp Asn Glu 
            740                 745                 750         


Ile Lys Ser His Leu Lys Ser Leu Pro Gln Met Glu Gly Ile Asp Phe 
        755                 760                 765             


Asn Asn Ala Asn Val Thr Tyr Leu Ile Ala Glu Tyr Met Lys Arg Val 
    770                 775                 780                 


Leu Asp Asp Asp Phe Gln Thr Phe Tyr Gln Trp Asn Arg Asn Tyr Arg 
785                 790                 795                 800 


Tyr Met Asp Met Leu Lys Gly Glu Tyr Asp Arg Lys Gly Ser Leu Gln 
                805                 810                 815     


His Cys Phe Thr Ser Val Glu Glu Arg Glu Gly Leu Trp Lys Glu Arg 
            820                 825                 830         


Ala Ser Arg Thr Glu Arg Tyr Arg Lys Gln Ala Ser Asn Lys Ile Arg 
        835                 840                 845             


Ser Asn Arg Gln Met Arg Asn Ala Ser Ser Glu Glu Ile Glu Thr Ile 
    850                 855                 860                 


Leu Asp Lys Arg Leu Ser Asn Ser Arg Asn Glu Tyr Gln Lys Ser Glu 
865                 870                 875                 880 


Lys Val Ile Arg Arg Tyr Arg Val Gln Asp Ala Leu Leu Phe Leu Leu 
                885                 890                 895     


Ala Lys Lys Thr Leu Thr Glu Leu Ala Asp Phe Asp Gly Glu Arg Phe 
            900                 905                 910         


Lys Leu Lys Glu Ile Met Pro Asp Ala Glu Lys Gly Ile Leu Ser Glu 
        915                 920                 925             


Ile Met Pro Met Ser Phe Thr Phe Glu Lys Gly Gly Lys Lys Tyr Thr 
    930                 935                 940                 


Ile Thr Ser Glu Gly Met Lys Leu Lys Asn Tyr Gly Asp Phe Phe Val 
945                 950                 955                 960 


Leu Ala Ser Asp Lys Arg Ile Gly Asn Leu Leu Glu Leu Val Gly Ser 
                965                 970                 975     


Asp Ile Val Ser Lys Glu Asp Gly Ser Leu Gln Leu Pro Pro Leu Glu 
            980                 985                 990         


Arg Leu Thr Leu Ser Gly Gly Ser  Ser Gly Gly Ser Ser  Gly Ser Glu 
        995                 1000                 1005             


Thr Pro  Gly Thr Ser Glu Ser  Ala Thr Pro Glu Ser  Ser Gly Gly 
    1010                 1015                 1020             


Ser Ser  Gly Gly Ser Val Gly  Gly Asp Ser Ser Ala  Asp Arg Leu 
    1025                 1030                 1035             


Phe Pro  Pro Gln Trp Ile Cys  Cys Asp Ile Arg Tyr  Leu Asp Val 
    1040                 1045                 1050             


Ser Ile  Leu Gly Lys Phe Ala  Val Val Met Ala Asp  Pro Pro Trp 
    1055                 1060                 1065             


Asp Ile  His Met Glu Leu Pro  Tyr Gly Thr Leu Thr  Asp Asp Glu 
    1070                 1075                 1080             


Met Arg  Arg Leu Asn Ile Pro  Val Leu Gln Asp Asp  Gly Phe Leu 
    1085                 1090                 1095             


Phe Leu  Trp Val Thr Gly Arg  Ala Met Glu Leu Gly  Arg Glu Cys 
    1100                 1105                 1110             


Leu Asn  Leu Trp Gly Tyr Glu  Arg Val Asp Glu Ile  Ile Trp Val 
    1115                 1120                 1125             


Lys Thr  Asn Gln Leu Gln Arg  Ile Ile Arg Thr Gly  Arg Thr Gly 
    1130                 1135                 1140             


His Trp  Leu Asn His Gly Lys  Glu His Cys Leu Val  Gly Val Lys 
    1145                 1150                 1155             


Gly Asn  Pro Gln Gly Phe Asn  Gln Gly Leu Asp Cys  Asp Val Ile 
    1160                 1165                 1170             


Val Ala  Glu Val Arg Ser Thr  Ser His Lys Pro Asp  Glu Ile Tyr 
    1175                 1180                 1185             


Gly Met  Ile Glu Arg Leu Ser  Pro Gly Thr Arg Lys  Ile Glu Leu 
    1190                 1195                 1200             


Phe Gly  Arg Pro His Asn Val  Gln Pro Asn Trp Ile  Thr Leu Gly 
    1205                 1210                 1215             


Asn Gln  Leu Asp Gly Ile His  Leu Leu Asp Pro Asp  Val Val Ala 
    1220                 1225                 1230             


Arg Phe  Lys Gln Arg Tyr Pro  Asp Gly Ile Ile Ser  Lys Pro Lys 
    1235                 1240                 1245             


Asn Leu  Gly Gly Ser Gly Gly  Ser Gly Gly Ser Gly  Gly Ser Gly 
    1250                 1255                 1260             


Gly Ser  Gly Gly Ser Gly Gly  Ser Gly Gly Ser Gly  Gly Ser Gly 
    1265                 1270                 1275             


Ser Gly  Gln Ser Leu Asn Pro  His Asn Asp Tyr Cys  Gln His Phe 
    1280                 1285                 1290             


Val Asp  Thr Gly His Arg Pro  Gln Asn Phe Ile Arg  Asp Val Gly 
    1295                 1300                 1305             


Leu Ala  Asp Arg Phe Glu Glu  Tyr Pro Lys Leu Arg  Glu Leu Ile 
    1310                 1315                 1320             


Arg Leu  Lys Asp Glu Leu Ile  Ala Lys Ser Asn Thr  Pro Pro Met 
    1325                 1330                 1335             


Tyr Leu  Gln Ala Asp Ile Glu  Ala Phe Asp Ile Arg  Glu Leu Thr 
    1340                 1345                 1350             


Pro Lys  Phe Asp Val Ile Leu  Leu Glu Pro Pro Leu  Glu Glu Tyr 
    1355                 1360                 1365             


Tyr Arg  Glu Thr Gly Ile Thr  Ala Asn Glu Lys Cys  Trp Thr Trp 
    1370                 1375                 1380             


Asp Asp  Ile Met Lys Leu Glu  Ile Asp Glu Ile Ala  Ala Pro Arg 
    1385                 1390                 1395             


Ser Phe  Ile Phe Leu Trp Cys  Gly Ser Gly Glu Gly  Leu Asp Leu 
    1400                 1405                 1410             


Gly Arg  Val Cys Leu Arg Lys  Trp Gly Tyr Arg Arg  Cys Glu Asp 
    1415                 1420                 1425             


Ile Cys  Trp Ile Lys Thr Asn  Lys Asn Asn Pro Gly  Lys Thr Lys 
    1430                 1435                 1440             


Thr Leu  Asp Pro Lys Ala Val  Phe Gln Arg Thr Lys  Glu His Cys 
    1445                 1450                 1455             


Leu Met  Gly Ile Lys Gly Thr  Val Lys Arg Ser Thr  Asp Gly Asp 
    1460                 1465                 1470             


Phe Ile  His Ala Asn Val Asp  Ile Asp Leu Ile Ile  Thr Glu Glu 
    1475                 1480                 1485             


Pro Glu  Ile Gly Asn Ile Glu  Lys Pro Val Glu Ile  Phe His Ile 
    1490                 1495                 1500             


Ile Glu  His Phe Cys Leu Gly  Arg Arg Arg Leu His  Leu Phe Gly 
    1505                 1510                 1515             


Arg Asp  Ser Thr Ile Arg Pro  Gly Trp Leu Thr Val  Gly Pro Thr 
    1520                 1525                 1530             


Leu Thr  Asn Ser Asn Tyr Asn  Ala Glu Thr Tyr Ala  Ser Tyr Phe 
    1535                 1540                 1545             


Ser Ala  Pro Asn Ser Tyr Leu  Thr Gly Cys Thr Glu  Glu Ile Glu 
    1550                 1555                 1560             


Arg Leu  Arg Pro Lys Ser Pro  Pro Pro Lys Ser Lys  Ser Asp Arg 
    1565                 1570                 1575             


Gly Gly  Gly Ala Pro Arg Gly  Gly Gly Arg Gly Gly  Thr Ser Ala 
    1580                 1585                 1590             


Gly Arg  Gly Arg Glu Arg Asn  Arg Ser Asn Phe Arg  Gly Glu Arg 
    1595                 1600                 1605             


Gly Gly  Phe Arg Gly Gly Arg  Gly Gly Ala His Arg  Gly Gly Phe 
    1610                 1615                 1620             


Pro Pro  Arg 
    1625     


<210>  27
<211>  1650
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  27

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Asn Ile Pro Ala Leu Val Glu Asn Gln Lys Lys Tyr Phe 
            20                  25                  30          


Gly Thr Tyr Ser Val Met Ala Met Leu Asn Ala Gln Thr Val Leu Asp 
        35                  40                  45              


His Ile Gln Lys Val Ala Asp Ile Glu Gly Glu Gln Asn Glu Asn Asn 
    50                  55                  60                  


Glu Asn Leu Trp Phe His Pro Val Met Ser His Leu Tyr Asn Ala Lys 
65                  70                  75                  80  


Asn Gly Tyr Asp Lys Gln Pro Glu Lys Thr Met Phe Ile Ile Glu Arg 
                85                  90                  95      


Leu Gln Ser Tyr Phe Pro Phe Leu Lys Ile Met Ala Glu Asn Gln Arg 
            100                 105                 110         


Glu Tyr Ser Asn Gly Lys Tyr Lys Gln Asn Arg Val Glu Val Asn Ser 
        115                 120                 125             


Asn Asp Ile Phe Glu Val Leu Lys Arg Ala Phe Gly Val Leu Lys Met 
    130                 135                 140                 


Tyr Arg Asp Leu Thr Asn Ala Tyr Lys Thr Tyr Glu Glu Lys Leu Asn 
145                 150                 155                 160 


Asp Gly Cys Glu Phe Leu Thr Ser Thr Glu Gln Pro Leu Ser Gly Met 
                165                 170                 175     


Ile Asn Asn Tyr Tyr Thr Val Ala Leu Arg Asn Met Asn Glu Arg Tyr 
            180                 185                 190         


Gly Tyr Lys Thr Glu Asp Leu Ala Phe Ile Gln Asp Lys Arg Phe Lys 
        195                 200                 205             


Phe Val Lys Asp Ala Tyr Gly Lys Lys Lys Ser Gln Val Asn Thr Gly 
    210                 215                 220                 


Phe Phe Leu Ser Leu Gln Asp Tyr Asn Gly Asp Thr Gln Lys Lys Leu 
225                 230                 235                 240 


His Leu Ser Gly Val Gly Ile Ala Leu Leu Ile Cys Leu Phe Leu Asp 
                245                 250                 255     


Lys Gln Tyr Ile Asn Ile Phe Leu Ser Arg Leu Pro Ile Phe Ser Ser 
            260                 265                 270         


Tyr Asn Ala Gln Ser Glu Glu Arg Arg Ile Ile Ile Arg Ser Phe Gly 
        275                 280                 285             


Ile Asn Ser Ile Lys Leu Pro Lys Asp Arg Ile His Ser Glu Lys Ser 
    290                 295                 300                 


Asn Lys Ser Val Ala Met Asp Met Leu Asn Glu Val Lys Arg Cys Pro 
305                 310                 315                 320 


Asp Glu Leu Phe Thr Thr Leu Ser Ala Glu Lys Gln Ser Arg Phe Arg 
                325                 330                 335     


Ile Ile Ser Asp Asp His Asn Glu Val Leu Met Lys Arg Ser Ser Asp 
            340                 345                 350         


Arg Phe Val Pro Leu Leu Leu Gln Tyr Ile Asp Tyr Gly Lys Leu Phe 
        355                 360                 365             


Asp His Ile Arg Phe His Val Asn Met Gly Lys Leu Arg Tyr Leu Leu 
    370                 375                 380                 


Lys Ala Asp Lys Thr Cys Ile Asp Gly Gln Thr Arg Val Arg Val Ile 
385                 390                 395                 400 


Glu Gln Pro Leu Asn Gly Phe Gly Arg Leu Glu Glu Ala Glu Thr Met 
                405                 410                 415     


Arg Lys Gln Glu Asn Gly Thr Phe Gly Asn Ser Gly Ile Arg Ile Arg 
            420                 425                 430         


Asp Phe Glu Asn Met Lys Arg Asp Asp Ala Asn Pro Ala Asn Tyr Pro 
        435                 440                 445             


Tyr Ile Val Asp Thr Tyr Thr His Tyr Ile Leu Glu Asn Asn Lys Val 
    450                 455                 460                 


Glu Met Phe Ile Asn Asp Lys Glu Asp Ser Ala Pro Leu Leu Pro Val 
465                 470                 475                 480 


Ile Glu Asp Asp Arg Tyr Val Val Lys Thr Ile Pro Ser Cys Arg Met 
                485                 490                 495     


Ser Thr Leu Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Phe Gly 
            500                 505                 510         


Ser Lys Lys Thr Glu Lys Leu Ile Val Asp Val His Asn Arg Tyr Lys 
        515                 520                 525             


Arg Leu Phe Gln Ala Met Gln Lys Glu Glu Val Thr Ala Glu Asn Ile 
    530                 535                 540                 


Ala Ser Phe Gly Ile Ala Glu Ser Asp Leu Pro Gln Lys Ile Leu Asp 
545                 550                 555                 560 


Leu Ile Ser Gly Asn Ala His Gly Lys Asp Val Asp Ala Phe Ile Arg 
                565                 570                 575     


Leu Thr Val Asp Asp Met Leu Thr Asp Thr Glu Arg Arg Ile Lys Arg 
            580                 585                 590         


Phe Lys Asp Asp Arg Lys Ser Ile Arg Ser Ala Asp Asn Lys Met Gly 
        595                 600                 605             


Lys Arg Gly Phe Lys Gln Ile Ser Thr Gly Lys Leu Ala Asp Phe Leu 
    610                 615                 620                 


Ala Lys Asp Ile Val Leu Phe Gln Pro Ser Val Asn Asp Gly Glu Asn 
625                 630                 635                 640 


Lys Ile Thr Gly Leu Asn Tyr Arg Ile Met Gln Ser Ala Ile Ala Val 
                645                 650                 655     


Tyr Asp Ser Gly Asp Asp Tyr Glu Ala Lys Gln Gln Phe Lys Leu Met 
            660                 665                 670         


Phe Glu Lys Ala Arg Leu Ile Gly Lys Gly Thr Thr Glu Pro His Pro 
        675                 680                 685             


Phe Leu Tyr Lys Val Phe Ala Arg Ser Ile Pro Ala Asn Ala Val Glu 
    690                 695                 700                 


Phe Tyr Glu Arg Tyr Leu Ile Glu Arg Lys Phe Tyr Leu Thr Gly Leu 
705                 710                 715                 720 


Ser Asn Glu Ile Lys Lys Gly Asn Arg Val Asp Val Pro Phe Ile Arg 
                725                 730                 735     


Arg Asp Gln Asn Lys Trp Lys Thr Pro Ala Met Lys Thr Leu Gly Arg 
            740                 745                 750         


Ile Tyr Ser Glu Asp Leu Pro Val Glu Leu Pro Arg Gln Met Phe Asp 
        755                 760                 765             


Asn Glu Ile Lys Ser His Leu Lys Ser Leu Pro Gln Met Glu Gly Ile 
    770                 775                 780                 


Asp Phe Asn Asn Ala Asn Val Thr Tyr Leu Ile Ala Glu Tyr Met Lys 
785                 790                 795                 800 


Arg Val Leu Asp Asp Asp Phe Gln Thr Phe Tyr Gln Trp Asn Arg Asn 
                805                 810                 815     


Tyr Arg Tyr Met Asp Met Leu Lys Gly Glu Tyr Asp Arg Lys Gly Ser 
            820                 825                 830         


Leu Gln His Cys Phe Thr Ser Val Glu Glu Arg Glu Gly Leu Trp Lys 
        835                 840                 845             


Glu Arg Ala Ser Arg Thr Glu Arg Tyr Arg Lys Gln Ala Ser Asn Lys 
    850                 855                 860                 


Ile Arg Ser Asn Arg Gln Met Arg Asn Ala Ser Ser Glu Glu Ile Glu 
865                 870                 875                 880 


Thr Ile Leu Asp Lys Arg Leu Ser Asn Ser Arg Asn Glu Tyr Gln Lys 
                885                 890                 895     


Ser Glu Lys Val Ile Arg Arg Tyr Arg Val Gln Asp Ala Leu Leu Phe 
            900                 905                 910         


Leu Leu Ala Lys Lys Thr Leu Thr Glu Leu Ala Asp Phe Asp Gly Glu 
        915                 920                 925             


Arg Phe Lys Leu Lys Glu Ile Met Pro Asp Ala Glu Lys Gly Ile Leu 
    930                 935                 940                 


Ser Glu Ile Met Pro Met Ser Phe Thr Phe Glu Lys Gly Gly Lys Lys 
945                 950                 955                 960 


Tyr Thr Ile Thr Ser Glu Gly Met Lys Leu Lys Asn Tyr Gly Asp Phe 
                965                 970                 975     


Phe Val Leu Ala Ser Asp Lys Arg Ile Gly Asn Leu Leu Glu Leu Val 
            980                 985                 990         


Gly Ser Asp Ile Val Ser Lys Glu  Asp Gly Ser Lys Arg  Thr Ala Asp 
        995                 1000                 1005             


Gly Ser  Glu Phe Glu Pro Lys  Lys Lys Arg Lys Val  Ser Gly Gly 
    1010                 1015                 1020             


Ser Ser  Gly Gly Ser Ser Gly  Ser Glu Thr Pro Gly  Thr Ser Glu 
    1025                 1030                 1035             


Ser Ala  Thr Pro Glu Ser Ser  Gly Gly Ser Ser Gly  Gly Ser Val 
    1040                 1045                 1050             


Gly Gly  Asp Ser Ser Ala Asp  Arg Leu Phe Pro Pro  Gln Trp Ile 
    1055                 1060                 1065             


Cys Cys  Asp Ile Arg Tyr Leu  Asp Val Ser Ile Leu  Gly Lys Phe 
    1070                 1075                 1080             


Ala Val  Val Met Ala Asp Pro  Pro Trp Asp Ile His  Met Glu Leu 
    1085                 1090                 1095             


Pro Tyr  Gly Thr Leu Thr Asp  Asp Glu Met Arg Arg  Leu Asn Ile 
    1100                 1105                 1110             


Pro Val  Leu Gln Asp Asp Gly  Phe Leu Phe Leu Trp  Val Thr Gly 
    1115                 1120                 1125             


Arg Ala  Met Glu Leu Gly Arg  Glu Cys Leu Asn Leu  Trp Gly Tyr 
    1130                 1135                 1140             


Glu Arg  Val Asp Glu Ile Ile  Trp Val Lys Thr Asn  Gln Leu Gln 
    1145                 1150                 1155             


Arg Ile  Ile Arg Thr Gly Arg  Thr Gly His Trp Leu  Asn His Gly 
    1160                 1165                 1170             


Lys Glu  His Cys Leu Val Gly  Val Lys Gly Asn Pro  Gln Gly Phe 
    1175                 1180                 1185             


Asn Gln  Gly Leu Asp Cys Asp  Val Ile Val Ala Glu  Val Arg Ser 
    1190                 1195                 1200             


Thr Ser  His Lys Pro Asp Glu  Ile Tyr Gly Met Ile  Glu Arg Leu 
    1205                 1210                 1215             


Ser Pro  Gly Thr Arg Lys Ile  Glu Leu Phe Gly Arg  Pro His Asn 
    1220                 1225                 1230             


Val Gln  Pro Asn Trp Ile Thr  Leu Gly Asn Gln Leu  Asp Gly Ile 
    1235                 1240                 1245             


His Leu  Leu Asp Pro Asp Val  Val Ala Arg Phe Lys  Gln Arg Tyr 
    1250                 1255                 1260             


Pro Asp  Gly Ile Ile Ser Lys  Pro Lys Asn Leu Gly  Gly Ser Gly 
    1265                 1270                 1275             


Gly Ser  Gly Gly Ser Gly Gly  Ser Gly Gly Ser Gly  Gly Ser Gly 
    1280                 1285                 1290             


Gly Ser  Gly Gly Ser Gly Gly  Ser Gly Ser Gly Gln  Ser Leu Asn 
    1295                 1300                 1305             


Pro His  Asn Asp Tyr Cys Gln  His Phe Val Asp Thr  Gly His Arg 
    1310                 1315                 1320             


Pro Gln  Asn Phe Ile Arg Asp  Val Gly Leu Ala Asp  Arg Phe Glu 
    1325                 1330                 1335             


Glu Tyr  Pro Lys Leu Arg Glu  Leu Ile Arg Leu Lys  Asp Glu Leu 
    1340                 1345                 1350             


Ile Ala  Lys Ser Asn Thr Pro  Pro Met Tyr Leu Gln  Ala Asp Ile 
    1355                 1360                 1365             


Glu Ala  Phe Asp Ile Arg Glu  Leu Thr Pro Lys Phe  Asp Val Ile 
    1370                 1375                 1380             


Leu Leu  Glu Pro Pro Leu Glu  Glu Tyr Tyr Arg Glu  Thr Gly Ile 
    1385                 1390                 1395             


Thr Ala  Asn Glu Lys Cys Trp  Thr Trp Asp Asp Ile  Met Lys Leu 
    1400                 1405                 1410             


Glu Ile  Asp Glu Ile Ala Ala  Pro Arg Ser Phe Ile  Phe Leu Trp 
    1415                 1420                 1425             


Cys Gly  Ser Gly Glu Gly Leu  Asp Leu Gly Arg Val  Cys Leu Arg 
    1430                 1435                 1440             


Lys Trp  Gly Tyr Arg Arg Cys  Glu Asp Ile Cys Trp  Ile Lys Thr 
    1445                 1450                 1455             


Asn Lys  Asn Asn Pro Gly Lys  Thr Lys Thr Leu Asp  Pro Lys Ala 
    1460                 1465                 1470             


Val Phe  Gln Arg Thr Lys Glu  His Cys Leu Met Gly  Ile Lys Gly 
    1475                 1480                 1485             


Thr Val  Lys Arg Ser Thr Asp  Gly Asp Phe Ile His  Ala Asn Val 
    1490                 1495                 1500             


Asp Ile  Asp Leu Ile Ile Thr  Glu Glu Pro Glu Ile  Gly Asn Ile 
    1505                 1510                 1515             


Glu Lys  Pro Val Glu Ile Phe  His Ile Ile Glu His  Phe Cys Leu 
    1520                 1525                 1530             


Gly Arg  Arg Arg Leu His Leu  Phe Gly Arg Asp Ser  Thr Ile Arg 
    1535                 1540                 1545             


Pro Gly  Trp Leu Thr Val Gly  Pro Thr Leu Thr Asn  Ser Asn Tyr 
    1550                 1555                 1560             


Asn Ala  Glu Thr Tyr Ala Ser  Tyr Phe Ser Ala Pro  Asn Ser Tyr 
    1565                 1570                 1575             


Leu Thr  Gly Cys Thr Glu Glu  Ile Glu Arg Leu Arg  Pro Lys Ser 
    1580                 1585                 1590             


Pro Pro  Pro Lys Ser Lys Ser  Asp Arg Gly Gly Gly  Ala Pro Arg 
    1595                 1600                 1605             


Gly Gly  Gly Arg Gly Gly Thr  Ser Ala Gly Arg Gly  Arg Glu Arg 
    1610                 1615                 1620             


Asn Arg  Ser Asn Phe Arg Gly  Glu Arg Gly Gly Phe  Arg Gly Gly 
    1625                 1630                 1635             


Arg Gly  Gly Ala His Arg Gly  Gly Phe Pro Pro Arg  
    1640                 1645                 1650 


<210>  28
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  28

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Tyr Pro Tyr Asp Val Pro Asp 
1               5                   10                  15      


Tyr Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
            20                  25          


<210>  29
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  29
gtaatgcctg gcttgtcgac gcatagtctg                                        30


<210>  30
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  30
ttccaaacta tcctgcggcc tctactctgc                                        30


<210>  31
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  31
tacatagctg cattcggaga tactctatgt                                        30


<210>  32
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  32
gaagcatttg cggtggacga tggaggggcc                                        30


<210>  33
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  33
agccccgcgg ccatcacgcc acagtttccc                                        30


<210>  34
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  34

Leu Gln Leu Pro Pro Leu Glu Arg Leu Thr Leu 
1               5                   10      


<210>  35
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<222>  (2)..(30)
<223>  may be absent

<400>  35

Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
            20                  25                  30  


<210>  36
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<222>  (4)..(90)
<223>  may be absent

<400>  36

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
            20                  25                  30          


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
        35                  40                  45              


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    50                  55                  60                  


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
65                  70                  75                  80  


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
                85                  90  


<210>  37
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(60)
<223>  may be absent

<400>  37

Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro 
1               5                   10                  15      


Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro 
            20                  25                  30          


Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro 
        35                  40                  45              


Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro 
    50                  55                  60  


<210>  38
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<222>  (4)..(21)
<223>  may be absent

<400>  38

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser 
            20      


