                               SEQUENCE LISTING

<110> AB STUDIO INC.
 
<120> NOVEL SYSTEMS FOR SCREENING INTERNALIZING ANTIBODY AND USES 
      THEREOF

<130> 129866-00120

<140>
<141>

<150> 62/700,331
<151> 2018-07-19

<160> 9     

<170> PatentIn version 3.5

<210> 1
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu His Leu Pro 
1               5                   10                  15      


Asn Leu Asn Glu Glu Gln Arg Asn Ala Phe Ile Gln Ser Leu Lys 
            20                  25                  30      


<210> 2
<211> 323
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu 
            20                  25                  30          


His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Ala Phe Ile Gln Ser 
        35                  40                  45              


Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Thr Ser Ile Thr Leu Asp Leu Val Asn Pro Thr Ala Gly Gln Tyr 
65                  70                  75                  80  


Ser Ser Phe Val Asp Lys Ile Arg Asn Asn Val Lys Asp Pro Asn Leu 
                85                  90                  95      


Lys Tyr Gly Gly Thr Asp Ile Ala Val Ile Gly Pro Pro Ser Lys Glu 
            100                 105                 110         


Lys Phe Leu Arg Ile Asn Phe Gln Ser Ser Arg Gly Thr Val Ser Leu 
        115                 120                 125             


Gly Leu Lys Arg Asp Asn Leu Tyr Val Val Ala Tyr Leu Ala Met Asp 
    130                 135                 140                 


Asn Thr Asn Val Asn Arg Ala Tyr Tyr Phe Arg Ser Glu Ile Thr Ser 
145                 150                 155                 160 


Ala Glu Ser Thr Ala Leu Phe Pro Glu Ala Thr Thr Ala Asn Gln Lys 
                165                 170                 175     


Ala Leu Glu Tyr Thr Glu Asp Tyr Gln Ser Ile Glu Lys Asn Ala Gln 
            180                 185                 190         


Ile Thr Gln Gly Asp Gln Ser Arg Lys Glu Leu Gly Leu Gly Ile Asp 
        195                 200                 205             


Leu Leu Ser Thr Ser Met Glu Ala Val Asn Lys Lys Ala Arg Val Val 
    210                 215                 220                 


Lys Asp Glu Ala Arg Phe Leu Leu Ile Ala Ile Gln Met Thr Ala Glu 
225                 230                 235                 240 


Ala Ala Arg Phe Arg Tyr Ile Gln Asn Leu Val Ile Lys Asn Phe Pro 
                245                 250                 255     


Asn Lys Phe Asn Ser Glu Asn Lys Val Ile Gln Phe Glu Val Asn Trp 
            260                 265                 270         


Lys Lys Ile Ser Thr Ala Ile Tyr Gly Asp Ala Lys Asn Gly Val Phe 
        275                 280                 285             


Asn Lys Asp Tyr Asp Phe Gly Phe Gly Lys Val Arg Gln Val Lys Asp 
    290                 295                 300                 


Leu Gln Met Gly Leu Leu Met Tyr Leu Gly Lys Pro Lys His His His 
305                 310                 315                 320 


His His His 
            


<210> 3
<211> 972
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
atggagtttg ggctgagctg gctttttctt gtggctattt taaaaggtgt ccagtgtttc       60

aacaaagaac aacaaaacgc cttctatgaa atcttgcact tgcctaactt gaacgaagaa      120

caacgcaatg ctttcatcca aagcttaaaa ggtggaggcg gttcaggtgg aggcggttca      180

ggtggaggcg gttcaacatc aatcacatta gatctagtaa atccgaccgc gggtcaatac      240

tcatcttttg tggataaaat ccgaaacaac gtaaaggatc caaacctgaa atacggtggt      300

accgacatag ccgtgatagg cccaccttct aaagaaaaat tccttagaat taatttccaa      360

agttcccgag gaacggtctc acttggccta aaacgcgata acttgtatgt ggtcgcgtat      420

cttgcaatgg ataacacgaa tgttaatcgg gcatattact tcagatcaga aattacttcc      480

gccgagtcaa ccgccctttt cccagaggcc acaactgcaa atcagaaagc tttagaatac      540

acagaagatt atcagtcgat tgaaaagaat gcccagataa cacaaggaga tcaaagtaga      600

aaagaactcg ggttggggat tgacttactt tcaacgtcca tggaagcagt gaacaagaag      660

gcacgtgtgg ttaaagacga agctagattc cttcttatcg ctattcagat gacggctgag      720

gcagcgcgat ttaggtacat acaaaacttg gtaatcaaga actttcccaa caagttcaac      780

tcggaaaaca aagtgattca gtttgaggtt aactggaaaa aaatttctac ggcaatatac      840

ggggatgcca aaaacggcgt gtttaataaa gattatgatt tcgggtttgg aaaagttagg      900

caggtgaagg acttgcaaat gggactcctt atgtatttgg gcaaaccaaa gcatcatcac      960

catcaccact ga                                                          972


<210> 4
<211> 252
<212> PRT
<213> Saponaria officinalis

<400> 4
Thr Ser Ile Thr Leu Asp Leu Val Asn Pro Thr Ala Gly Gln Tyr Ser 
1               5                   10                  15      


Ser Phe Val Asp Lys Ile Arg Asn Asn Val Lys Asp Pro Asn Leu Lys 
            20                  25                  30          


Tyr Gly Gly Thr Asp Ile Ala Val Ile Gly Pro Pro Ser Lys Glu Lys 
        35                  40                  45              


Phe Leu Arg Ile Asn Phe Gln Ser Ser Arg Gly Thr Val Ser Leu Gly 
    50                  55                  60                  


Leu Lys Arg Asp Asn Leu Tyr Val Val Ala Tyr Leu Ala Met Asp Asn 
65                  70                  75                  80  


Thr Asn Val Asn Arg Ala Tyr Tyr Phe Arg Ser Glu Ile Thr Ser Ala 
                85                  90                  95      


Glu Ser Thr Ala Leu Phe Pro Glu Ala Thr Thr Ala Asn Gln Lys Ala 
            100                 105                 110         


Leu Glu Tyr Thr Glu Asp Tyr Gln Ser Ile Glu Lys Asn Ala Gln Ile 
        115                 120                 125             


Thr Gln Gly Asp Gln Ser Arg Lys Glu Leu Gly Leu Gly Ile Asp Leu 
    130                 135                 140                 


Leu Ser Thr Ser Met Glu Ala Val Asn Lys Lys Ala Arg Val Val Lys 
145                 150                 155                 160 


Asp Glu Ala Arg Phe Leu Leu Ile Ala Ile Gln Met Thr Ala Glu Ala 
                165                 170                 175     


Ala Arg Phe Arg Tyr Ile Gln Asn Leu Val Ile Lys Asn Phe Pro Asn 
            180                 185                 190         


Lys Phe Asn Ser Glu Asn Lys Val Ile Gln Phe Glu Val Asn Trp Lys 
        195                 200                 205             


Lys Ile Ser Thr Ala Ile Tyr Gly Asp Ala Lys Asn Gly Val Phe Asn 
    210                 215                 220                 


Lys Asp Tyr Asp Phe Gly Phe Gly Lys Val Arg Gln Val Lys Asp Leu 
225                 230                 235                 240 


Gln Met Gly Leu Leu Met Tyr Leu Gly Lys Pro Lys 
                245                 250         


<210> 5
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 6
<211> 298
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu His Leu Pro 
1               5                   10                  15      


Asn Leu Asn Glu Glu Gln Arg Asn Ala Phe Ile Gln Ser Leu Lys Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Ser 
        35                  40                  45              


Ile Thr Leu Asp Leu Val Asn Pro Thr Ala Gly Gln Tyr Ser Ser Phe 
    50                  55                  60                  


Val Asp Lys Ile Arg Asn Asn Val Lys Asp Pro Asn Leu Lys Tyr Gly 
65                  70                  75                  80  


Gly Thr Asp Ile Ala Val Ile Gly Pro Pro Ser Lys Glu Lys Phe Leu 
                85                  90                  95      


Arg Ile Asn Phe Gln Ser Ser Arg Gly Thr Val Ser Leu Gly Leu Lys 
            100                 105                 110         


Arg Asp Asn Leu Tyr Val Val Ala Tyr Leu Ala Met Asp Asn Thr Asn 
        115                 120                 125             


Val Asn Arg Ala Tyr Tyr Phe Arg Ser Glu Ile Thr Ser Ala Glu Ser 
    130                 135                 140                 


Thr Ala Leu Phe Pro Glu Ala Thr Thr Ala Asn Gln Lys Ala Leu Glu 
145                 150                 155                 160 


Tyr Thr Glu Asp Tyr Gln Ser Ile Glu Lys Asn Ala Gln Ile Thr Gln 
                165                 170                 175     


Gly Asp Gln Ser Arg Lys Glu Leu Gly Leu Gly Ile Asp Leu Leu Ser 
            180                 185                 190         


Thr Ser Met Glu Ala Val Asn Lys Lys Ala Arg Val Val Lys Asp Glu 
        195                 200                 205             


Ala Arg Phe Leu Leu Ile Ala Ile Gln Met Thr Ala Glu Ala Ala Arg 
    210                 215                 220                 


Phe Arg Tyr Ile Gln Asn Leu Val Ile Lys Asn Phe Pro Asn Lys Phe 
225                 230                 235                 240 


Asn Ser Glu Asn Lys Val Ile Gln Phe Glu Val Asn Trp Lys Lys Ile 
                245                 250                 255     


Ser Thr Ala Ile Tyr Gly Asp Ala Lys Asn Gly Val Phe Asn Lys Asp 
            260                 265                 270         


Tyr Asp Phe Gly Phe Gly Lys Val Arg Gln Val Lys Asp Leu Gln Met 
        275                 280                 285             


Gly Leu Leu Met Tyr Leu Gly Lys Pro Lys 
    290                 295             


<210> 7
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210> 8
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 8
His His His His His His 
1               5       


<210> 9
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser 
1               5                   10                  15  


