                         SEQUENCE LISTING

<110>  Health Research, Inc.
 
<120>  MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) CLASS II-EXPRESSING CANCER
        CELL VACCINE AND METHODS OF USE FOR PRODUCING INTEGRATED IMMUNE 
       RESPONSES

<130>  003551.00812

<150>  62/701,791
<151>  2018-07-22

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  3468
<212>  DNA
<213>  Mus musculus

<400>  1
atgaaccact tccaggccat cctggcccaa gtacagacac tgctctccag ccagaagccc       60

aggcaggtgc gggccctcct ggatggcctg ctggaagaag agctgctctc acgggaatac      120

cactgtgcct tgctgcatga gcctgatggt gatgccctgg cccggaagat ttccctgacc      180

ctgctggaga aaggggactt agacttgact ttcttgagct gggtctgcaa cagtctgcag      240

gctcccacgg tagagagggg caccagctac agggaccatg gagaccatag tctgtgtgcc      300

accatggatc tgggatctcc agagggcagc tacctggaac tccttaacag tgatgccgac      360

cccctacatc tctaccacct ctatgaccag atggacctgg ctggggagga ggagatcgaa      420

ctcagctcag agccagacac agataccatc aactgcgacc agttcagcaa gctgttgcag      480

gacatggaac tggatgaaga gacccgggag gcctatgcca acattgcgga actggatcag      540

tacgtgttcc aggataccca gctcgagggc ctgagcaagg acctcttcat agagcacatt      600

ggagcagagg aaggctttgg tgagaacata gagatccctg tagaagcagg acagaagcct      660

cagaagagac gcttcccgga agagcatgct atggactcaa agcacaggaa gctagtgccc      720

acctctagga cctcactgaa ctatttggat ctccccactg ggcacatcca gatcttcacc      780

actctgcccc agggactctg gcaaatctca ggggctggca caggtctctc cagtgtccta      840

atctaccacg gtgagatgcc ccaggtcaac caagtgctcc cttcaagcag cctcagtatc      900

cccagtctcc ccgagtcccc agaccggcct ggctccacca gccccttcac accatctgca      960

gctgacctgc ccagcatgcc cgaacctgcg ctgacctccc gtgtaaatga gacagaggac     1020

acatctccct ccccatgcca agagggtccc gagtcttcca tcaagcttcc aaaatggcca     1080

gaggctgtgg agcgattcca gcactcccta caggacaaat acaaggcatt gccccagagc     1140

ccaaggggtc ctctggtggc cgtggagctg gtacgggcca ggctggaaag aggcagcaac     1200

aagagccagg aaagggagct ggccactccc gactggacag agcgccagct agcccacggt     1260

ggtctggcag aggtacttca ggttgtcagt gactgcaggc gaccaggaga gacacaggtg     1320

gtcgctgtgc tgggcaaggc tggccaggga aagagccact gggccaggac agtgagtcac     1380

acctgggcat gtggccagtt gctacaatat gactttgtct tctatgtccc ctgtcattgc     1440

ttggatcgtc ccggggacac ctaccacctg cgggatctgc tctgtccccc gagcctgcag     1500

ccactggcca tggatgacga ggtccttgat tatatcgtga ggcagccaga ccgtgttctg     1560

ctcatcctag atgctttcga ggagctagag gcccaagatg gcctcctgca cggaccctgt     1620

ggatctctgt ccccagagcc ctgctccctc cgaggactgc tggctgggat cttccagcgg     1680

aagctactgc gaggctgcac actgctcctc acagcccggc cccggggccg cctggctcag     1740

agcctgagca aggcagatgc catctttgag gtgcccagct tctctaccaa gcaggccaag     1800

acttacatga ggcactactt tgagaactca gggacagcgg ggaaccaaga caaggccctg     1860

ggcctcctgg agggccagcc tcttctctgc agctatagtc acagccctgt tgtgtgcagg     1920

gctgtgtgcc agctctccaa ggccctgcta gaacagggca cagaggccca gctaccttgt     1980

acacttacag gactctatgt cagcctgcta ggtcctgcag ctcagaacag tcctcccgga     2040

gccttagtcg agctggccaa gctggcctgg gagctgggac gaagacacca aagcaccttg     2100

caagaaaccc ggttttcatc cgtggaggtg aaaacctggg cagtgaccca aggcttgatg     2160

cagcagaccc tggagaccac ggaggctcaa ctggccttct ccagttttct gctacagtgt     2220

ttcctgggtg ctgtgtggct ggcacagtgc aatgaaatca aagacaagga gctgccacag     2280

tacctggcct tgactccgag gaagaagaga ccctatgaca actggctgga gggtgtacca     2340

cgctttctgg ctggattagt tttccagcct cgagcccact gcctgggagc tctggtggag     2400

cctgcagtgg ctgcagtggc ggataggaaa cagaaggttc ttaccaggta cctgaagcgc     2460

ctgaagctgg ggacactccg ggcagggagg ctgctggagc tgctccactg tgcccacgag     2520

acacagcaac ctgggatatg ggagcatgtt gcacaccagc tccctggcca cctctccttc     2580

ctgggcaccc ggctcacacc cccagatgtg tatgtgctgg gcagggcctt ggagacagcc     2640

agccaggact tctccttgga ccttcgtcag actggcgttg agccttctgg actgggaaac     2700

ctcgtgggac tcagctgtgt caccagtttc agggcctcct tgagtgatac aatggcatta     2760

tgggagtccc ttcagcagca gggagaagcc cagctactcc aggcggcaga ggagaagttc     2820

accattgagc catttaaagc caaatcccca aaggatgtgg aagacctgga tcgtctcgtg     2880

cagacccaga ggctgagaaa cccctcagaa gatgcagcca aggatcttcc tgccatccgg     2940

gaccttaaga agctagagtt tgcgttgggc cccatcttgg gcccccaggc tttccccaca     3000

ctggcaaaga tccttccagc cttctcttct ctgcaacacc tggacctgga ctcacttagt     3060

gagaacaaga tcggagacaa gggtgtgtcg aagctctcag ccaccttccc tcagctgaag     3120

gccctggaga cgctcaactt gtcccaaaac aacatcactg atgtgggtgc ctgcaagctt     3180

gcagaagctc tgccagccct agccaagtcc ctcctaaggc tgagcttgta caataactgc     3240

atctgtgaca aaggagccaa gagcctggca caagtacttc cggacatggt gtccctgcgt     3300

gtgatggatg tccagttcaa caagttcacg gctgccggtg cccagcaact ggcctccagc     3360

cttcagaagt gccctcaggt ggaaacactg gcaatgtgga cacccactat cccctttggg     3420

gttcaggaac acctgcagca gctggatgcc aggatcagtc tgagatga                  3468


<210>  2
<211>  1155
<212>  PRT
<213>  Mus musculus

<400>  2

Met Asn His Phe Gln Ala Ile Leu Ala Gln Val Gln Thr Leu Leu Ser 
1               5                   10                  15      


Ser Gln Lys Pro Arg Gln Val Arg Ala Leu Leu Asp Gly Leu Leu Glu 
            20                  25                  30          


Glu Glu Leu Leu Ser Arg Glu Tyr His Cys Ala Leu Leu His Glu Pro 
        35                  40                  45              


Asp Gly Asp Ala Leu Ala Arg Lys Ile Ser Leu Thr Leu Leu Glu Lys 
    50                  55                  60                  


Gly Asp Leu Asp Leu Thr Phe Leu Ser Trp Val Cys Asn Ser Leu Gln 
65                  70                  75                  80  


Ala Pro Thr Val Glu Arg Gly Thr Ser Tyr Arg Asp His Gly Asp His 
                85                  90                  95      


Ser Leu Cys Ala Thr Met Asp Leu Gly Ser Pro Glu Gly Ser Tyr Leu 
            100                 105                 110         


Glu Leu Leu Asn Ser Asp Ala Asp Pro Leu His Leu Tyr His Leu Tyr 
        115                 120                 125             


Asp Gln Met Asp Leu Ala Gly Glu Glu Glu Ile Glu Leu Ser Ser Glu 
    130                 135                 140                 


Pro Asp Thr Asp Thr Ile Asn Cys Asp Gln Phe Ser Lys Leu Leu Gln 
145                 150                 155                 160 


Asp Met Glu Leu Asp Glu Glu Thr Arg Glu Ala Tyr Ala Asn Ile Ala 
                165                 170                 175     


Glu Leu Asp Gln Tyr Val Phe Gln Asp Thr Gln Leu Glu Gly Leu Ser 
            180                 185                 190         


Lys Asp Leu Phe Ile Glu His Ile Gly Ala Glu Glu Gly Phe Gly Glu 
        195                 200                 205             


Asn Ile Glu Ile Pro Val Glu Ala Gly Gln Lys Pro Gln Lys Arg Arg 
    210                 215                 220                 


Phe Pro Glu Glu His Ala Met Asp Ser Lys His Arg Lys Leu Val Pro 
225                 230                 235                 240 


Thr Ser Arg Thr Ser Leu Asn Tyr Leu Asp Leu Pro Thr Gly His Ile 
                245                 250                 255     


Gln Ile Phe Thr Thr Leu Pro Gln Gly Leu Trp Gln Ile Ser Gly Ala 
            260                 265                 270         


Gly Thr Gly Leu Ser Ser Val Leu Ile Tyr His Gly Glu Met Pro Gln 
        275                 280                 285             


Val Asn Gln Val Leu Pro Ser Ser Ser Leu Ser Ile Pro Ser Leu Pro 
    290                 295                 300                 


Glu Ser Pro Asp Arg Pro Gly Ser Thr Ser Pro Phe Thr Pro Ser Ala 
305                 310                 315                 320 


Ala Asp Leu Pro Ser Met Pro Glu Pro Ala Leu Thr Ser Arg Val Asn 
                325                 330                 335     


Glu Thr Glu Asp Thr Ser Pro Ser Pro Cys Gln Glu Gly Pro Glu Ser 
            340                 345                 350         


Ser Ile Lys Leu Pro Lys Trp Pro Glu Ala Val Glu Arg Phe Gln His 
        355                 360                 365             


Ser Leu Gln Asp Lys Tyr Lys Ala Leu Pro Gln Ser Pro Arg Gly Pro 
    370                 375                 380                 


Leu Val Ala Val Glu Leu Val Arg Ala Arg Leu Glu Arg Gly Ser Asn 
385                 390                 395                 400 


Lys Ser Gln Glu Arg Glu Leu Ala Thr Pro Asp Trp Thr Glu Arg Gln 
                405                 410                 415     


Leu Ala His Gly Gly Leu Ala Glu Val Leu Gln Val Val Ser Asp Cys 
            420                 425                 430         


Arg Arg Pro Gly Glu Thr Gln Val Val Ala Val Leu Gly Lys Ala Gly 
        435                 440                 445             


Gln Gly Lys Ser His Trp Ala Arg Thr Val Ser His Thr Trp Ala Cys 
    450                 455                 460                 


Gly Gln Leu Leu Gln Tyr Asp Phe Val Phe Tyr Val Pro Cys His Cys 
465                 470                 475                 480 


Leu Asp Arg Pro Gly Asp Thr Tyr His Leu Arg Asp Leu Leu Cys Pro 
                485                 490                 495     


Pro Ser Leu Gln Pro Leu Ala Met Asp Asp Glu Val Leu Asp Tyr Ile 
            500                 505                 510         


Val Arg Gln Pro Asp Arg Val Leu Leu Ile Leu Asp Ala Phe Glu Glu 
        515                 520                 525             


Leu Glu Ala Gln Asp Gly Leu Leu His Gly Pro Cys Gly Ser Leu Ser 
    530                 535                 540                 


Pro Glu Pro Cys Ser Leu Arg Gly Leu Leu Ala Gly Ile Phe Gln Arg 
545                 550                 555                 560 


Lys Leu Leu Arg Gly Cys Thr Leu Leu Leu Thr Ala Arg Pro Arg Gly 
                565                 570                 575     


Arg Leu Ala Gln Ser Leu Ser Lys Ala Asp Ala Ile Phe Glu Val Pro 
            580                 585                 590         


Ser Phe Ser Thr Lys Gln Ala Lys Thr Tyr Met Arg His Tyr Phe Glu 
        595                 600                 605             


Asn Ser Gly Thr Ala Gly Asn Gln Asp Lys Ala Leu Gly Leu Leu Glu 
    610                 615                 620                 


Gly Gln Pro Leu Leu Cys Ser Tyr Ser His Ser Pro Val Val Cys Arg 
625                 630                 635                 640 


Ala Val Cys Gln Leu Ser Lys Ala Leu Leu Glu Gln Gly Thr Glu Ala 
                645                 650                 655     


Gln Leu Pro Cys Thr Leu Thr Gly Leu Tyr Val Ser Leu Leu Gly Pro 
            660                 665                 670         


Ala Ala Gln Asn Ser Pro Pro Gly Ala Leu Val Glu Leu Ala Lys Leu 
        675                 680                 685             


Ala Trp Glu Leu Gly Arg Arg His Gln Ser Thr Leu Gln Glu Thr Arg 
    690                 695                 700                 


Phe Ser Ser Val Glu Val Lys Thr Trp Ala Val Thr Gln Gly Leu Met 
705                 710                 715                 720 


Gln Gln Thr Leu Glu Thr Thr Glu Ala Gln Leu Ala Phe Ser Ser Phe 
                725                 730                 735     


Leu Leu Gln Cys Phe Leu Gly Ala Val Trp Leu Ala Gln Cys Asn Glu 
            740                 745                 750         


Ile Lys Asp Lys Glu Leu Pro Gln Tyr Leu Ala Leu Thr Pro Arg Lys 
        755                 760                 765             


Lys Arg Pro Tyr Asp Asn Trp Leu Glu Gly Val Pro Arg Phe Leu Ala 
    770                 775                 780                 


Gly Leu Val Phe Gln Pro Arg Ala His Cys Leu Gly Ala Leu Val Glu 
785                 790                 795                 800 


Pro Ala Val Ala Ala Val Ala Asp Arg Lys Gln Lys Val Leu Thr Arg 
                805                 810                 815     


Tyr Leu Lys Arg Leu Lys Leu Gly Thr Leu Arg Ala Gly Arg Leu Leu 
            820                 825                 830         


Glu Leu Leu His Cys Ala His Glu Thr Gln Gln Pro Gly Ile Trp Glu 
        835                 840                 845             


His Val Ala His Gln Leu Pro Gly His Leu Ser Phe Leu Gly Thr Arg 
    850                 855                 860                 


Leu Thr Pro Pro Asp Val Tyr Val Leu Gly Arg Ala Leu Glu Thr Ala 
865                 870                 875                 880 


Ser Gln Asp Phe Ser Leu Asp Leu Arg Gln Thr Gly Val Glu Pro Ser 
                885                 890                 895     


Gly Leu Gly Asn Leu Val Gly Leu Ser Cys Val Thr Ser Phe Arg Ala 
            900                 905                 910         


Ser Leu Ser Asp Thr Met Ala Leu Trp Glu Ser Leu Gln Gln Gln Gly 
        915                 920                 925             


Glu Ala Gln Leu Leu Gln Ala Ala Glu Glu Lys Phe Thr Ile Glu Pro 
    930                 935                 940                 


Phe Lys Ala Lys Ser Pro Lys Asp Val Glu Asp Leu Asp Arg Leu Val 
945                 950                 955                 960 


Gln Thr Gln Arg Leu Arg Asn Pro Ser Glu Asp Ala Ala Lys Asp Leu 
                965                 970                 975     


Pro Ala Ile Arg Asp Leu Lys Lys Leu Glu Phe Ala Leu Gly Pro Ile 
            980                 985                 990         


Leu Gly Pro Gln Ala Phe Pro Thr  Leu Ala Lys Ile Leu  Pro Ala Phe 
        995                 1000                 1005             


Ser Ser  Leu Gln His Leu Asp  Leu Asp Ser Leu Ser  Glu Asn Lys 
    1010                 1015                 1020             


Ile Gly  Asp Lys Gly Val Ser  Lys Leu Ser Ala Thr  Phe Pro Gln 
    1025                 1030                 1035             


Leu Lys  Ala Leu Glu Thr Leu  Asn Leu Ser Gln Asn  Asn Ile Thr 
    1040                 1045                 1050             


Asp Val  Gly Ala Cys Lys Leu  Ala Glu Ala Leu Pro  Ala Leu Ala 
    1055                 1060                 1065             


Lys Ser  Leu Leu Arg Leu Ser  Leu Tyr Asn Asn Cys  Ile Cys Asp 
    1070                 1075                 1080             


Lys Gly  Ala Lys Ser Leu Ala  Gln Val Leu Pro Asp  Met Val Ser 
    1085                 1090                 1095             


Leu Arg  Val Met Asp Val Gln  Phe Asn Lys Phe Thr  Ala Ala Gly 
    1100                 1105                 1110             


Ala Gln  Gln Leu Ala Ser Ser  Leu Gln Lys Cys Pro  Gln Val Glu 
    1115                 1120                 1125             


Thr Leu  Ala Met Trp Thr Pro  Thr Ile Pro Phe Gly  Val Gln Glu 
    1130                 1135                 1140             


His Leu  Gln Gln Leu Asp Ala  Arg Ile Ser Leu Arg  
    1145                 1150                 1155 


<210>  3
<211>  930
<212>  DNA
<213>  Mus musculus

<400>  3
atggaccagc acacacttga tgtggaggat accgcggatg ccagacatcc agcaggtact       60

tcgtgcccct cggatgcggc gctcctcaga gataccgggc tcctcgcgga cgctgcgctc      120

ctctcagata ctgtgcgccc cacaaatgcc gcgctcccca cggatgctgc ctaccctgcg      180

gttaatgttc gggatcgcga ggccgcgtgg ccgcctgcac tgaacttctg ttcccgccac      240

ccaaagctct atggcctagt cgctttggtt ttgctgcttc tgatcgccgc ctgtgttcct      300

atcttcaccc gcaccgagcc tcggccagcg ctcacaatca ccacctcgcc caacctgggt      360

acccgagaga ataatgcaga ccaggtcacc cctgtttccc acattggctg ccccaacact      420

acacaacagg gctctcctgt gttcgccaag ctactggcta aaaaccaagc atcgttgtgc      480

aatacaactc tgaactggca cagccaagat ggagctggga gctcatacct atctcaaggt      540

ctgaggtacg aagaagacaa aaaggagttg gtggtagaca gtcccgggct ctactacgta      600

tttttggaac tgaagctcag tccaacattc acaaacacag gccacaaggt gcagggctgg      660

gtctctcttg ttttgcaagc aaagcctcag gtagatgact ttgacaactt ggccctgaca      720

gtggaactgt tcccttgctc catggagaac aagttagtgg accgttcctg gagtcaactg      780

ttgctcctga aggctggcca ccgcctcagt gtgggtctga gggcttatct gcatggagcc      840

caggatgcat acagagactg ggagctgtct tatcccaaca ccaccagctt tggactcttt      900

cttgtgaaac ccgacaaccc atgggaatga                                       930


<210>  4
<211>  309
<212>  PRT
<213>  Mus musculus

<400>  4

Met Asp Gln His Thr Leu Asp Val Glu Asp Thr Ala Asp Ala Arg His 
1               5                   10                  15      


Pro Ala Gly Thr Ser Cys Pro Ser Asp Ala Ala Leu Leu Arg Asp Thr 
            20                  25                  30          


Gly Leu Leu Ala Asp Ala Ala Leu Leu Ser Asp Thr Val Arg Pro Thr 
        35                  40                  45              


Asn Ala Ala Leu Pro Thr Asp Ala Ala Tyr Pro Ala Val Asn Val Arg 
    50                  55                  60                  


Asp Arg Glu Ala Ala Trp Pro Pro Ala Leu Asn Phe Cys Ser Arg His 
65                  70                  75                  80  


Pro Lys Leu Tyr Gly Leu Val Ala Leu Val Leu Leu Leu Leu Ile Ala 
                85                  90                  95      


Ala Cys Val Pro Ile Phe Thr Arg Thr Glu Pro Arg Pro Ala Leu Thr 
            100                 105                 110         


Ile Thr Thr Ser Pro Asn Leu Gly Thr Arg Glu Asn Asn Ala Asp Gln 
        115                 120                 125             


Val Thr Pro Val Ser His Ile Gly Cys Pro Asn Thr Thr Gln Gln Gly 
    130                 135                 140                 


Ser Pro Val Phe Ala Lys Leu Leu Ala Lys Asn Gln Ala Ser Leu Cys 
145                 150                 155                 160 


Asn Thr Thr Leu Asn Trp His Ser Gln Asp Gly Ala Gly Ser Ser Tyr 
                165                 170                 175     


Leu Ser Gln Gly Leu Arg Tyr Glu Glu Asp Lys Lys Glu Leu Val Val 
            180                 185                 190         


Asp Ser Pro Gly Leu Tyr Tyr Val Phe Leu Glu Leu Lys Leu Ser Pro 
        195                 200                 205             


Thr Phe Thr Asn Thr Gly His Lys Val Gln Gly Trp Val Ser Leu Val 
    210                 215                 220                 


Leu Gln Ala Lys Pro Gln Val Asp Asp Phe Asp Asn Leu Ala Leu Thr 
225                 230                 235                 240 


Val Glu Leu Phe Pro Cys Ser Met Glu Asn Lys Leu Val Asp Arg Ser 
                245                 250                 255     


Trp Ser Gln Leu Leu Leu Leu Lys Ala Gly His Arg Leu Ser Val Gly 
            260                 265                 270         


Leu Arg Ala Tyr Leu His Gly Ala Gln Asp Ala Tyr Arg Asp Trp Glu 
        275                 280                 285             


Leu Ser Tyr Pro Asn Thr Thr Ser Phe Gly Leu Phe Leu Val Lys Pro 
    290                 295                 300                 


Asp Asn Pro Trp Glu 
305                 


<210>  5
<211>  597
<212>  DNA
<213>  Mus musculus

<400>  5
atggaagggg aaggggttca acccctggat gagaatctgg aaaacggatc aaggccaaga       60

ttcaagtgga agaagacgct aaggctggtg gtctctggga tcaagggagc agggatgctt      120

ctgtgcttca tctatgtctg cctgcaactc tcttcctctc cggcaaagga ccctccaatc      180

caaagactca gaggagcagt taccagatgt gaggatgggc aactattcat cagctcatac      240

aagaatgagt atcaaactat ggaggtgcag aacaattcgg ttgtcatcaa gtgcgatggg      300

ctttatatca tctacctgaa gggctccttt ttccaggagg tcaagattga ccttcatttc      360

cgggaggatc ataatcccat ctctattcca atgctgaacg atggtcgaag gattgtcttc      420

actgtggtgg cctctttggc tttcaaagat aaagtttacc tgactgtaaa tgctcctgat      480

actctctgcg aacacctcca gataaatgat ggggagctga ttgttgtcca gctaacgcct      540

ggatactgtg ctcctgaagg atcttaccac agcactgtga accaagtacc actgtga         597


<210>  6
<211>  198
<212>  PRT
<213>  Mus musculus

<400>  6

Met Glu Gly Glu Gly Val Gln Pro Leu Asp Glu Asn Leu Glu Asn Gly 
1               5                   10                  15      


Ser Arg Pro Arg Phe Lys Trp Lys Lys Thr Leu Arg Leu Val Val Ser 
            20                  25                  30          


Gly Ile Lys Gly Ala Gly Met Leu Leu Cys Phe Ile Tyr Val Cys Leu 
        35                  40                  45              


Gln Leu Ser Ser Ser Pro Ala Lys Asp Pro Pro Ile Gln Arg Leu Arg 
    50                  55                  60                  


Gly Ala Val Thr Arg Cys Glu Asp Gly Gln Leu Phe Ile Ser Ser Tyr 
65                  70                  75                  80  


Lys Asn Glu Tyr Gln Thr Met Glu Val Gln Asn Asn Ser Val Val Ile 
                85                  90                  95      


Lys Cys Asp Gly Leu Tyr Ile Ile Tyr Leu Lys Gly Ser Phe Phe Gln 
            100                 105                 110         


Glu Val Lys Ile Asp Leu His Phe Arg Glu Asp His Asn Pro Ile Ser 
        115                 120                 125             


Ile Pro Met Leu Asn Asp Gly Arg Arg Ile Val Phe Thr Val Val Ala 
    130                 135                 140                 


Ser Leu Ala Phe Lys Asp Lys Val Tyr Leu Thr Val Asn Ala Pro Asp 
145                 150                 155                 160 


Thr Leu Cys Glu His Leu Gln Ile Asn Asp Gly Glu Leu Ile Val Val 
                165                 170                 175     


Gln Leu Thr Pro Gly Tyr Cys Ala Pro Glu Gly Ser Tyr His Ser Thr 
            180                 185                 190         


Val Asn Gln Val Pro Leu 
        195             


<210>  7
<211>  522
<212>  DNA
<213>  Mus musculus

<400>  7
atggaggaaa tgcctttgag agaatcaagt cctcaaaggg cagagaggtg caagaagtca       60

tggctcttgt gcatagtggc tctgttactg atgttgctct gttctttggg tacactgatc      120

tatacttcac tcaagccaac tgccatcgag tcctgcatgg ttaagtttga actatcatcc      180

tcaaaatggc acatgacatc tcccaaacct cactgtgtga atacgacatc tgatgggaag      240

ctgaagatac tgcagagtgg cacatattta atctacggcc aagtgattcc tgtggataag      300

aaatacataa aagacaatgc ccccttcgta gtacagatat ataaaaagaa tgatgtccta      360

caaactctaa tgaatgattt tcaaatcttg cctataggag gggtttatga actgcatgct      420

ggagataaca tatatctgaa gttcaactct aaagaccata ttcagaaaac taacacatac      480

tgggggatca tcttaatgcc tgatctacca ttcatctctt ag                         522


<210>  8
<211>  173
<212>  PRT
<213>  Mus musculus

<400>  8

Met Glu Glu Met Pro Leu Arg Glu Ser Ser Pro Gln Arg Ala Glu Arg 
1               5                   10                  15      


Cys Lys Lys Ser Trp Leu Leu Cys Ile Val Ala Leu Leu Leu Met Leu 
            20                  25                  30          


Leu Cys Ser Leu Gly Thr Leu Ile Tyr Thr Ser Leu Lys Pro Thr Ala 
        35                  40                  45              


Ile Glu Ser Cys Met Val Lys Phe Glu Leu Ser Ser Ser Lys Trp His 
    50                  55                  60                  


Met Thr Ser Pro Lys Pro His Cys Val Asn Thr Thr Ser Asp Gly Lys 
65                  70                  75                  80  


Leu Lys Ile Leu Gln Ser Gly Thr Tyr Leu Ile Tyr Gly Gln Val Ile 
                85                  90                  95      


Pro Val Asp Lys Lys Tyr Ile Lys Asp Asn Ala Pro Phe Val Val Gln 
            100                 105                 110         


Ile Tyr Lys Lys Asn Asp Val Leu Gln Thr Leu Met Asn Asp Phe Gln 
        115                 120                 125             


Ile Leu Pro Ile Gly Gly Val Tyr Glu Leu His Ala Gly Asp Asn Ile 
    130                 135                 140                 


Tyr Leu Lys Phe Asn Ser Lys Asp His Ile Gln Lys Thr Asn Thr Tyr 
145                 150                 155                 160 


Trp Gly Ile Ile Leu Met Pro Asp Leu Pro Phe Ile Ser 
                165                 170             


<210>  9
<211>  921
<212>  DNA
<213>  Mus musculus

<400>  9
atggcttgca attgtcagtt gatgcaggat acaccactcc tcaagtttcc atgtccaagg       60

ctcattcttc tctttgtgct gctgattcgt ctttcacaag tgtcttcaga tgttgatgaa      120

caactgtcca agtcagtgaa agataaggta ttgctgcctt gccgttacaa ctctcctcat      180

gaagatgagt ctgaagaccg aatctactgg caaaaacatg acaaagtggt gctgtctgtc      240

attgctggga aactaaaagt gtggcccgag tataagaacc ggactttata tgacaacact      300

acctactctc ttatcatcct gggcctggtc ctttcagacc ggggcacata cagctgtgtc      360

gttcaaaaga aggaaagagg aacgtatgaa gttaaacact tggctttagt aaagttgtcc      420

atcaaagctg acttctctac ccccaacata actgagtctg gaaacccatc tgcagacact      480

aaaaggatta cctgctttgc ttccgggggt ttcccaaagc ctcgcttctc ttggttggaa      540

aatggaagag aattacctgg catcaatacg acaatttccc aggatcctga atctgaattg      600

tacaccatta gtagccaact agatttcaat acgactcgca accacaccat taagtgtctc      660

attaaatatg gagatgctca cgtgtcagag gacttcacct gggaaaaacc cccagaagac      720

cctcctgata gcaagaacac acttgtgctc tttggggcag gattcggcgc agtaataaca      780

gtcgtcgtca tcgttgtcat catcaaatgc ttctgtaagc acagaagctg tttcagaaga      840

aatgaggcaa gcagagaaac aaacaacagc cttaccttcg ggcctgaaga agcattagct      900

gaacagaccg tcttccttta g                                                921


<210>  10
<211>  306
<212>  PRT
<213>  Mus musculus

<400>  10

Met Ala Cys Asn Cys Gln Leu Met Gln Asp Thr Pro Leu Leu Lys Phe 
1               5                   10                  15      


Pro Cys Pro Arg Leu Ile Leu Leu Phe Val Leu Leu Ile Arg Leu Ser 
            20                  25                  30          


Gln Val Ser Ser Asp Val Asp Glu Gln Leu Ser Lys Ser Val Lys Asp 
        35                  40                  45              


Lys Val Leu Leu Pro Cys Arg Tyr Asn Ser Pro His Glu Asp Glu Ser 
    50                  55                  60                  


Glu Asp Arg Ile Tyr Trp Gln Lys His Asp Lys Val Val Leu Ser Val 
65                  70                  75                  80  


Ile Ala Gly Lys Leu Lys Val Trp Pro Glu Tyr Lys Asn Arg Thr Leu 
                85                  90                  95      


Tyr Asp Asn Thr Thr Tyr Ser Leu Ile Ile Leu Gly Leu Val Leu Ser 
            100                 105                 110         


Asp Arg Gly Thr Tyr Ser Cys Val Val Gln Lys Lys Glu Arg Gly Thr 
        115                 120                 125             


Tyr Glu Val Lys His Leu Ala Leu Val Lys Leu Ser Ile Lys Ala Asp 
    130                 135                 140                 


Phe Ser Thr Pro Asn Ile Thr Glu Ser Gly Asn Pro Ser Ala Asp Thr 
145                 150                 155                 160 


Lys Arg Ile Thr Cys Phe Ala Ser Gly Gly Phe Pro Lys Pro Arg Phe 
                165                 170                 175     


Ser Trp Leu Glu Asn Gly Arg Glu Leu Pro Gly Ile Asn Thr Thr Ile 
            180                 185                 190         


Ser Gln Asp Pro Glu Ser Glu Leu Tyr Thr Ile Ser Ser Gln Leu Asp 
        195                 200                 205             


Phe Asn Thr Thr Arg Asn His Thr Ile Lys Cys Leu Ile Lys Tyr Gly 
    210                 215                 220                 


Asp Ala His Val Ser Glu Asp Phe Thr Trp Glu Lys Pro Pro Glu Asp 
225                 230                 235                 240 


Pro Pro Asp Ser Lys Asn Thr Leu Val Leu Phe Gly Ala Gly Phe Gly 
                245                 250                 255     


Ala Val Ile Thr Val Val Val Ile Val Val Ile Ile Lys Cys Phe Cys 
            260                 265                 270         


Lys His Arg Ser Cys Phe Arg Arg Asn Glu Ala Ser Arg Glu Thr Asn 
        275                 280                 285             


Asn Ser Leu Thr Phe Gly Pro Glu Glu Ala Leu Ala Glu Gln Thr Val 
    290                 295                 300                 


Phe Leu 
305     


<210>  11
<211>  426
<212>  DNA
<213>  Mus musculus

<400>  11
atgtggctgc agaatttact tttcctgggc attgtggtct acagcctctc agcacccacc       60

cgctcaccca tcactgtcac ccggccttgg aagcatgtag aggccatcaa agaagccctg      120

aacctcctgg atgacatgcc tgtcacgttg aatgaagagg tagaagtcgt ctctaacgag      180

ttctccttca agaagctaac atgtgtgcag acccgcctga agatattcga gcagggtcta      240

cggggcaatt tcaccaaact caagggcgcc ttgaacatga cagccagcta ctaccagaca      300

tactgccccc caactccgga aacggactgt gaaacacaag ttaccaccta tgcggatttc      360

atagacagcc ttaaaacctt tctgactgat atcccctttg aatgcaaaaa accaggccaa      420

aaatga                                                                 426


<210>  12
<211>  141
<212>  PRT
<213>  Mus musculus

<400>  12

Met Trp Leu Gln Asn Leu Leu Phe Leu Gly Ile Val Val Tyr Ser Leu 
1               5                   10                  15      


Ser Ala Pro Thr Arg Ser Pro Ile Thr Val Thr Arg Pro Trp Lys His 
            20                  25                  30          


Val Glu Ala Ile Lys Glu Ala Leu Asn Leu Leu Asp Asp Met Pro Val 
        35                  40                  45              


Thr Leu Asn Glu Glu Val Glu Val Val Ser Asn Glu Phe Ser Phe Lys 
    50                  55                  60                  


Lys Leu Thr Cys Val Gln Thr Arg Leu Lys Ile Phe Glu Gln Gly Leu 
65                  70                  75                  80  


Arg Gly Asn Phe Thr Lys Leu Lys Gly Ala Leu Asn Met Thr Ala Ser 
                85                  90                  95      


Tyr Tyr Gln Thr Tyr Cys Pro Pro Thr Pro Glu Thr Asp Cys Glu Thr 
            100                 105                 110         


Gln Val Thr Thr Tyr Ala Asp Phe Ile Asp Ser Leu Lys Thr Phe Leu 
        115                 120                 125             


Thr Asp Ile Pro Phe Glu Cys Lys Lys Pro Gly Gln Lys 
    130                 135                 140     


<210>  13
<211>  3396
<212>  DNA
<213>  Homo sapiens

<400>  13
atgcgttgcc tggctccacg ccctgctggg tcctacctgt cagagcccca aggcagctca       60

cagtgtgcca ccatggagtt ggggccccta gaaggtggct acctggagct tcttaacagc      120

gatgctgacc ccctgtgcct ctaccacttc tatgaccaga tggacctggc tggagaagaa      180

gagattgagc tctactcaga acccgacaca gacaccatca actgcgacca gttcagcagg      240

ctgttgtgtg acatggaagg tgatgaagag accagggagg cttatgccaa tatcgcggaa      300

ctggaccagt atgtcttcca ggactcccag ctggagggcc tgagcaagga cattttcata      360

gagcacatag gaccagatga agtgatcggt gagagtatgg agatgccagc agaagttggg      420

cagaaaagtc agaaaagacc cttcccagag gagcttccgg cagacctgaa gcactggaag      480

ccagctgagc cccccactgt ggtgactggc agtctcctag tgggaccagt gagcgactgc      540

tccaccctgc cctgcctgcc actgcctgcg ctgttcaacc aggagccagc ctccggccag      600

atgcgcctgg agaaaaccga ccagattccc atgcctttct ccagttcctc gttgagctgc      660

ctgaatctcc ctgagggacc catccagttt gtccccacca tctccactct gccccatggg      720

ctctggcaaa tctctgaggc tggaacaggg gtctccagta tattcatcta ccatggtgag      780

gtgccccagg ccagccaagt accccctccc agtggattca ctgtccacgg cctcccaaca      840

tctccagacc ggccaggctc caccagcccc ttcgctccat cagccactga cctgcccagc      900

atgcctgaac ctgccctgac ctcccgagca aacatgacag agcacaagac gtcccccacc      960

caatgcccgg cagctggaga ggtctccaac aagcttccaa aatggcctga gccggtggag     1020

cagttctacc gctcactgca ggacacgtat ggtgccgagc ccgcaggccc ggatggcatc     1080

ctagtggagg tggatctggt gcaggccagg ctggagagga gcagcagcaa gagcctggag     1140

cgggaactgg ccaccccgga ctgggcagaa cggcagctgg cccaaggagg cctggctgag     1200

gtgctgttgg ctgccaagga gcaccggcgg ccgcgtgaga cacgagtgat tgctgtgctg     1260

ggcaaagctg gtcagggcaa gagctattgg gctggggcag tgagccgggc ctgggcttgt     1320

ggccggcttc cccagtacga ctttgtcttc tctgtcccct gccattgctt gaaccgtccg     1380

ggggatgcct atggcctgca ggatctgctc ttctccctgg gcccacagcc actcgtggcg     1440

gccgatgagg ttttcagcca catcttgaag agacctgacc gcgttctgct catcctagac     1500

ggcttcgagg agctggaagc gcaagatggc ttcctgcaca gcacgtgcgg accggcaccg     1560

gcggagccct gctccctccg ggggctgctg gccggccttt tccagaagaa gctgctccga     1620

ggttgcaccc tcctcctcac agcccggccc cggggccgcc tggtccagag cctgagcaag     1680

gccgacgccc tatttgagct gtccggcttc tccatggagc aggcccaggc atacgtgatg     1740

cgctactttg agagctcagg gatgacagag caccaagaca gagccctgac gctcctccgg     1800

gaccggccac ttcttctcag tcacagccac agccctactt tgtgccgggc agtgtgccag     1860

ctctcagagg ccctgctgga gcttggggag gacgccaagc tgccctccac gctcacggga     1920

ctctatgtcg gcctgctggg ccgtgcagcc ctcgacagcc cccccggggc cctggcagag     1980

ctggccaagc tggcctggga gctgggccgc agacatcaaa gtaccctaca ggaggaccag     2040

ttcccatccg cagacgtgag gacctgggcg atggccaaag gcttagtcca acacccaccg     2100

cgggccgcag agtccgagct ggccttcccc agcttcctcc tgcaatgctt cctgggggcc     2160

ctgtggctgg ctctgagtgg cgaaatcaag gacaaggagc tcccgcagta cctagcattg     2220

accccaagga agaagaggcc ctatgacaac tggctggagg gcgtgccacg ctttctggct     2280

gggctgatct tccagcctcc cgcccgctgc ctgggagccc tactcgggcc atcggcggct     2340

gcctcggtgg acaggaagca gaaggtgctt gcgaggtacc tgaagcggct gcagccgggg     2400

acactgcggg cgcggcagct gctggagctg ctgcactgcg cccacgaggc cgaggaggct     2460

ggaatttggc agcacgtggt acaggagctc cccggccgcc tctcttttct gggcacccgc     2520

ctcacgcctc ctgatgcaca tgtactgggc aaggccttgg aggcggcggg ccaagacttc     2580

tccctggacc tccgcagcac tggcatttgc ccctctggat tggggagcct cgtgggactc     2640

agctgtgtca cccgtttcag ggctgccttg agcgacacgg tggcgctgtg ggagtccctg     2700

cagcagcatg gggagaccaa gctacttcag gcagcagagg agaagttcac catcgagcct     2760

ttcaaagcca agtccctgaa ggatgtggaa gacctgggaa agcttgtgca gactcagagg     2820

acgagaagtt cctcggaaga cacagctggg gagctccctg ctgttcggga cctaaagaaa     2880

ctggagtttg cgctgggccc tgtctcaggc ccccaggctt tccccaaact ggtgcggatc     2940

ctcacggcct tttcctccct gcagcatctg gacctggatg cgctgagtga gaacaagatc     3000

ggggacgagg gtgtctcgca gctctcagcc accttccccc agctgaagtc cttggaaacc     3060

ctcaatctgt cccagaacaa catcactgac ctgggtgcct acaaactcgc cgaggccctg     3120

ccttcgctcg ctgcatccct gctcaggcta agcttgtaca ataactgcat ctgcgacgtg     3180

ggagccgaga gcttggctcg tgtgcttccg gacatggtgt ccctccgggt gatggacgtc     3240

cagtacaaca agttcacggc tgccggggcc cagcagctcg ctgccagcct tcggaggtgt     3300

cctcatgtgg agacgctggc gatgtggacg cccaccatcc cattcagtgt ccaggaacac     3360

ctgcaacaac aggattcacg gatcagcctg agatga                               3396


<210>  14
<211>  1131
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Arg Cys Leu Ala Pro Arg Pro Ala Gly Ser Tyr Leu Ser Glu Pro 
1               5                   10                  15      


Gln Gly Ser Ser Gln Cys Ala Thr Met Glu Leu Gly Pro Leu Glu Gly 
            20                  25                  30          


Gly Tyr Leu Glu Leu Leu Asn Ser Asp Ala Asp Pro Leu Cys Leu Tyr 
        35                  40                  45              


His Phe Tyr Asp Gln Met Asp Leu Ala Gly Glu Glu Glu Ile Glu Leu 
    50                  55                  60                  


Tyr Ser Glu Pro Asp Thr Asp Thr Ile Asn Cys Asp Gln Phe Ser Arg 
65                  70                  75                  80  


Leu Leu Cys Asp Met Glu Gly Asp Glu Glu Thr Arg Glu Ala Tyr Ala 
                85                  90                  95      


Asn Ile Ala Glu Leu Asp Gln Tyr Val Phe Gln Asp Ser Gln Leu Glu 
            100                 105                 110         


Gly Leu Ser Lys Asp Ile Phe Ile Glu His Ile Gly Pro Asp Glu Val 
        115                 120                 125             


Ile Gly Glu Ser Met Glu Met Pro Ala Glu Val Gly Gln Lys Ser Gln 
    130                 135                 140                 


Lys Arg Pro Phe Pro Glu Glu Leu Pro Ala Asp Leu Lys His Trp Lys 
145                 150                 155                 160 


Pro Ala Glu Pro Pro Thr Val Val Thr Gly Ser Leu Leu Val Gly Pro 
                165                 170                 175     


Val Ser Asp Cys Ser Thr Leu Pro Cys Leu Pro Leu Pro Ala Leu Phe 
            180                 185                 190         


Asn Gln Glu Pro Ala Ser Gly Gln Met Arg Leu Glu Lys Thr Asp Gln 
        195                 200                 205             


Ile Pro Met Pro Phe Ser Ser Ser Ser Leu Ser Cys Leu Asn Leu Pro 
    210                 215                 220                 


Glu Gly Pro Ile Gln Phe Val Pro Thr Ile Ser Thr Leu Pro His Gly 
225                 230                 235                 240 


Leu Trp Gln Ile Ser Glu Ala Gly Thr Gly Val Ser Ser Ile Phe Ile 
                245                 250                 255     


Tyr His Gly Glu Val Pro Gln Ala Ser Gln Val Pro Pro Pro Ser Gly 
            260                 265                 270         


Phe Thr Val His Gly Leu Pro Thr Ser Pro Asp Arg Pro Gly Ser Thr 
        275                 280                 285             


Ser Pro Phe Ala Pro Ser Ala Thr Asp Leu Pro Ser Met Pro Glu Pro 
    290                 295                 300                 


Ala Leu Thr Ser Arg Ala Asn Met Thr Glu His Lys Thr Ser Pro Thr 
305                 310                 315                 320 


Gln Cys Pro Ala Ala Gly Glu Val Ser Asn Lys Leu Pro Lys Trp Pro 
                325                 330                 335     


Glu Pro Val Glu Gln Phe Tyr Arg Ser Leu Gln Asp Thr Tyr Gly Ala 
            340                 345                 350         


Glu Pro Ala Gly Pro Asp Gly Ile Leu Val Glu Val Asp Leu Val Gln 
        355                 360                 365             


Ala Arg Leu Glu Arg Ser Ser Ser Lys Ser Leu Glu Arg Glu Leu Ala 
    370                 375                 380                 


Thr Pro Asp Trp Ala Glu Arg Gln Leu Ala Gln Gly Gly Leu Ala Glu 
385                 390                 395                 400 


Val Leu Leu Ala Ala Lys Glu His Arg Arg Pro Arg Glu Thr Arg Val 
                405                 410                 415     


Ile Ala Val Leu Gly Lys Ala Gly Gln Gly Lys Ser Tyr Trp Ala Gly 
            420                 425                 430         


Ala Val Ser Arg Ala Trp Ala Cys Gly Arg Leu Pro Gln Tyr Asp Phe 
        435                 440                 445             


Val Phe Ser Val Pro Cys His Cys Leu Asn Arg Pro Gly Asp Ala Tyr 
    450                 455                 460                 


Gly Leu Gln Asp Leu Leu Phe Ser Leu Gly Pro Gln Pro Leu Val Ala 
465                 470                 475                 480 


Ala Asp Glu Val Phe Ser His Ile Leu Lys Arg Pro Asp Arg Val Leu 
                485                 490                 495     


Leu Ile Leu Asp Gly Phe Glu Glu Leu Glu Ala Gln Asp Gly Phe Leu 
            500                 505                 510         


His Ser Thr Cys Gly Pro Ala Pro Ala Glu Pro Cys Ser Leu Arg Gly 
        515                 520                 525             


Leu Leu Ala Gly Leu Phe Gln Lys Lys Leu Leu Arg Gly Cys Thr Leu 
    530                 535                 540                 


Leu Leu Thr Ala Arg Pro Arg Gly Arg Leu Val Gln Ser Leu Ser Lys 
545                 550                 555                 560 


Ala Asp Ala Leu Phe Glu Leu Ser Gly Phe Ser Met Glu Gln Ala Gln 
                565                 570                 575     


Ala Tyr Val Met Arg Tyr Phe Glu Ser Ser Gly Met Thr Glu His Gln 
            580                 585                 590         


Asp Arg Ala Leu Thr Leu Leu Arg Asp Arg Pro Leu Leu Leu Ser His 
        595                 600                 605             


Ser His Ser Pro Thr Leu Cys Arg Ala Val Cys Gln Leu Ser Glu Ala 
    610                 615                 620                 


Leu Leu Glu Leu Gly Glu Asp Ala Lys Leu Pro Ser Thr Leu Thr Gly 
625                 630                 635                 640 


Leu Tyr Val Gly Leu Leu Gly Arg Ala Ala Leu Asp Ser Pro Pro Gly 
                645                 650                 655     


Ala Leu Ala Glu Leu Ala Lys Leu Ala Trp Glu Leu Gly Arg Arg His 
            660                 665                 670         


Gln Ser Thr Leu Gln Glu Asp Gln Phe Pro Ser Ala Asp Val Arg Thr 
        675                 680                 685             


Trp Ala Met Ala Lys Gly Leu Val Gln His Pro Pro Arg Ala Ala Glu 
    690                 695                 700                 


Ser Glu Leu Ala Phe Pro Ser Phe Leu Leu Gln Cys Phe Leu Gly Ala 
705                 710                 715                 720 


Leu Trp Leu Ala Leu Ser Gly Glu Ile Lys Asp Lys Glu Leu Pro Gln 
                725                 730                 735     


Tyr Leu Ala Leu Thr Pro Arg Lys Lys Arg Pro Tyr Asp Asn Trp Leu 
            740                 745                 750         


Glu Gly Val Pro Arg Phe Leu Ala Gly Leu Ile Phe Gln Pro Pro Ala 
        755                 760                 765             


Arg Cys Leu Gly Ala Leu Leu Gly Pro Ser Ala Ala Ala Ser Val Asp 
    770                 775                 780                 


Arg Lys Gln Lys Val Leu Ala Arg Tyr Leu Lys Arg Leu Gln Pro Gly 
785                 790                 795                 800 


Thr Leu Arg Ala Arg Gln Leu Leu Glu Leu Leu His Cys Ala His Glu 
                805                 810                 815     


Ala Glu Glu Ala Gly Ile Trp Gln His Val Val Gln Glu Leu Pro Gly 
            820                 825                 830         


Arg Leu Ser Phe Leu Gly Thr Arg Leu Thr Pro Pro Asp Ala His Val 
        835                 840                 845             


Leu Gly Lys Ala Leu Glu Ala Ala Gly Gln Asp Phe Ser Leu Asp Leu 
    850                 855                 860                 


Arg Ser Thr Gly Ile Cys Pro Ser Gly Leu Gly Ser Leu Val Gly Leu 
865                 870                 875                 880 


Ser Cys Val Thr Arg Phe Arg Ala Ala Leu Ser Asp Thr Val Ala Leu 
                885                 890                 895     


Trp Glu Ser Leu Gln Gln His Gly Glu Thr Lys Leu Leu Gln Ala Ala 
            900                 905                 910         


Glu Glu Lys Phe Thr Ile Glu Pro Phe Lys Ala Lys Ser Leu Lys Asp 
        915                 920                 925             


Val Glu Asp Leu Gly Lys Leu Val Gln Thr Gln Arg Thr Arg Ser Ser 
    930                 935                 940                 


Ser Glu Asp Thr Ala Gly Glu Leu Pro Ala Val Arg Asp Leu Lys Lys 
945                 950                 955                 960 


Leu Glu Phe Ala Leu Gly Pro Val Ser Gly Pro Gln Ala Phe Pro Lys 
                965                 970                 975     


Leu Val Arg Ile Leu Thr Ala Phe Ser Ser Leu Gln His Leu Asp Leu 
            980                 985                 990         


Asp Ala Leu Ser Glu Asn Lys Ile  Gly Asp Glu Gly Val  Ser Gln Leu 
        995                 1000                 1005             


Ser Ala  Thr Phe Pro Gln Leu  Lys Ser Leu Glu Thr  Leu Asn Leu 
    1010                 1015                 1020             


Ser Gln  Asn Asn Ile Thr Asp  Leu Gly Ala Tyr Lys  Leu Ala Glu 
    1025                 1030                 1035             


Ala Leu  Pro Ser Leu Ala Ala  Ser Leu Leu Arg Leu  Ser Leu Tyr 
    1040                 1045                 1050             


Asn Asn  Cys Ile Cys Asp Val  Gly Ala Glu Ser Leu  Ala Arg Val 
    1055                 1060                 1065             


Leu Pro  Asp Met Val Ser Leu  Arg Val Met Asp Val  Gln Tyr Asn 
    1070                 1075                 1080             


Lys Phe  Thr Ala Ala Gly Ala  Gln Gln Leu Ala Ala  Ser Leu Arg 
    1085                 1090                 1095             


Arg Cys  Pro His Val Glu Thr  Leu Ala Met Trp Thr  Pro Thr Ile 
    1100                 1105                 1110             


Pro Phe  Ser Val Gln Glu His  Leu Gln Gln Gln Asp  Ser Arg Ile 
    1115                 1120                 1125             


Ser Leu  Arg 
    1130     


<210>  15
<211>  765
<212>  DNA
<213>  Homo sapiens

<400>  15
atggaatacg cctctgacgc ttcactggac cccgaagccc cgtggcctcc cgcgccccgc       60

gctcgcgcct gccgcgtact gccttgggcc ctggtcgcgg ggctgctgct gctgctgctg      120

ctcgctgccg cctgcgccgt cttcctcgcc tgcccctggg ccgtgtccgg ggctcgcgcc      180

tcgcccggct ccgcggccag cccgagactc cgcgagggtc ccgagctttc gcccgacgat      240

cccgccggcc tcttggacct gcggcagggc atgtttgcgc agctggtggc ccaaaatgtt      300

ctgctgatcg atgggcccct gagctggtac agtgacccag gcctggcagg cgtgtccctg      360

acggggggcc tgagctacaa agaggacacg aaggagctgg tggtggccaa ggctggagtc      420

tactatgtct tctttcaact agagctgcgg cgcgtggtgg ccggcgaggg ctcaggctcc      480

gtttcacttg cgctgcacct gcagccactg cgctctgctg ctggggccgc cgccctggct      540

ttgaccgtgg acctgccacc cgcctcctcc gaggctcgga actcggcctt cggtttccag      600

ggccgcttgc tgcacctgag tgccggccag cgcctgggcg tccatcttca cactgaggcc      660

agggcacgcc atgcctggca gcttacccag ggcgccacag tcttgggact cttccgggtg      720

acccccgaaa tcccagccgg actcccttca ccgaggtcgg aataa                      765


<210>  16
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
1               5                   10                  15      


Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
            20                  25                  30          


Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
        35                  40                  45              


Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
    50                  55                  60                  


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
65                  70                  75                  80  


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                85                  90                  95      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            100                 105                 110         


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        115                 120                 125             


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    130                 135                 140                 


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
145                 150                 155                 160 


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                165                 170                 175     


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            180                 185                 190         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        195                 200                 205             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    210                 215                 220                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
225                 230                 235                 240 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                245                 250                 


<210>  17
<211>  552
<212>  DNA
<213>  Homo sapiens

<400>  17
atggaaaggg tccaacccct ggaagagaat gtgggaaatg cagccaggcc aagattcgag       60

aggaacaagc tattgctggt ggcctctgta attcagggac tggggctgct cctgtgcttc      120

acctacatct gcctgcactt ctctgctctt caggtatcac atcggtatcc tcgaattcaa      180

agtatcaaag tacaatttac cgaatataag aaggagaaag gtttcatcct cacttcccaa      240

aaggaggatg aaatcatgaa ggtgcagaac aactcagtca tcatcaactg tgatgggttt      300

tatctcatct ccctgaaggg ctacttctcc caggaagtca acattagcct tcattaccag      360

aaggatgagg agcccctctt ccaactgaag aaggtcaggt ctgtcaactc cttgatggtg      420

gcctctctga cttacaaaga caaagtctac ttgaatgtga ccactgacaa tacctccctg      480

gatgacttcc atgtgaatgg cggagaactg attcttatcc atcaaaatcc tggtgaattc      540

tgtgtccttt ga                                                          552


<210>  18
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Glu Arg Val Gln Pro Leu Glu Glu Asn Val Gly Asn Ala Ala Arg 
1               5                   10                  15      


Pro Arg Phe Glu Arg Asn Lys Leu Leu Leu Val Ala Ser Val Ile Gln 
            20                  25                  30          


Gly Leu Gly Leu Leu Leu Cys Phe Thr Tyr Ile Cys Leu His Phe Ser 
        35                  40                  45              


Ala Leu Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val 
    50                  55                  60                  


Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln 
65                  70                  75                  80  


Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn 
                85                  90                  95      


Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu 
            100                 105                 110         


Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln 
        115                 120                 125             


Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr 
    130                 135                 140                 


Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu 
145                 150                 155                 160 


Asp Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn 
                165                 170                 175     


Pro Gly Glu Phe Cys Val Leu 
            180             


<210>  19
<211>  600
<212>  DNA
<213>  Homo sapiens

<400>  19
atgacattgc atccttcacc catcacttgt gaatttttgt tttccacagc tctcatttct       60

ccaaaaatgt gtttgagcca cttggaaaat atgcctttaa gccattcaag aactcaagga      120

gctcagagat catcctggaa gctgtggctc ttttgctcaa tagttatgtt gctatttctt      180

tgctccttca gttggctaat ctttattttt ctccaattag agactgctaa ggagccctgt      240

atggctaagt ttggaccatt accctcaaaa tggcaaatgg catcttctga acctccttgc      300

gtgaataagg tgtctgactg gaagctggag atacttcaga atggcttata tttaatttat      360

ggccaagtgg ctcccaatgc aaactacaat gatgtagctc cttttgaggt gcggctgtat      420

aaaaacaaag acatgataca aactctaaca aacaaatcta aaatccaaaa tgtaggaggg      480

acttatgaat tgcatgttgg ggacaccata gacttgatat tcaactctga gcatcaggtt      540

ctaaaaaata atacatactg gggtatcatt ttactagcaa atccccaatt catctcctag      600


<210>  20
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Thr Leu His Pro Ser Pro Ile Thr Cys Glu Phe Leu Phe Ser Thr 
1               5                   10                  15      


Ala Leu Ile Ser Pro Lys Met Cys Leu Ser His Leu Glu Asn Met Pro 
            20                  25                  30          


Leu Ser His Ser Arg Thr Gln Gly Ala Gln Arg Ser Ser Trp Lys Leu 
        35                  40                  45              


Trp Leu Phe Cys Ser Ile Val Met Leu Leu Phe Leu Cys Ser Phe Ser 
    50                  55                  60                  


Trp Leu Ile Phe Ile Phe Leu Gln Leu Glu Thr Ala Lys Glu Pro Cys 
65                  70                  75                  80  


Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser Ser 
                85                  90                  95      


Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile Leu 
            100                 105                 110         


Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn 
        115                 120                 125             


Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp 
    130                 135                 140                 


Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly Gly 
145                 150                 155                 160 


Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser 
                165                 170                 175     


Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu 
            180                 185                 190         


Ala Asn Pro Gln Phe Ile Ser 
        195                 


<210>  21
<211>  990
<212>  DNA
<213>  Homo sapiens

<400>  21
atggatcccc agtgcactat gggactgagt aacattctct ttgtgatggc cttcctgctc       60

tctggtgctg ctcctctgaa gattcaagct tatttcaatg agactgcaga cctgccatgc      120

caatttgcaa actctcaaaa ccaaagcctg agtgagctag tagtattttg gcaggaccag      180

gaaaacttgg ttctgaatga ggtatactta ggcaaagaga aatttgacag tgttcattcc      240

aagtatatgg gccgcacaag ttttgattcg gacagttgga ccctgagact tcacaatctt      300

cagatcaagg acaagggctt gtatcaatgt atcatccatc acaaaaagcc cacaggaatg      360

attcgcatcc accagatgaa ttctgaactg tcagtgcttg ctaacttcag tcaacctgaa      420

atagtaccaa tttctaatat aacagaaaat gtgtacataa atttgacctg ctcatctata      480

cacggttacc cagaacctaa gaagatgagt gttttgctaa gaaccaagaa ttcaactatc      540

gagtatgatg gtattatgca gaaatctcaa gataatgtca cagaactgta cgacgtttcc      600

atcagcttgt ctgtttcatt ccctgatgtt acgagcaata tgaccatctt ctgtattctg      660

gaaactgaca agacgcggct tttatcttca cctttctcta tagagcttga ggaccctcag      720

cctcccccag accacattcc ttggattaca gctgtacttc caacagttat tatatgtgtg      780

atggttttct gtctaattct atggaaatgg aagaagaaga agcggcctcg caactcttat      840

aaatgtggaa ccaacacaat ggagagggaa gagagtgaac agaccaagaa aagagaaaaa      900

atccatatac ctgaaagatc tgatgaagcc cagcgtgttt ttaaaagttc gaagacatct      960

tcatgcgaca aaagtgatac atgtttttaa                                       990


<210>  22
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val Met 
1               5                   10                  15      


Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe 
            20                  25                  30          


Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln 
        35                  40                  45              


Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln Glu Asn Leu Val 
    50                  55                  60                  


Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe Asp Ser Val His Ser 
65                  70                  75                  80  


Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg 
                85                  90                  95      


Leu His Asn Leu Gln Ile Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile 
            100                 105                 110         


His His Lys Lys Pro Thr Gly Met Ile Arg Ile His Gln Met Asn Ser 
        115                 120                 125             


Glu Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Val Pro Ile 
    130                 135                 140                 


Ser Asn Ile Thr Glu Asn Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile 
145                 150                 155                 160 


His Gly Tyr Pro Glu Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys 
                165                 170                 175     


Asn Ser Thr Ile Glu Tyr Asp Gly Ile Met Gln Lys Ser Gln Asp Asn 
            180                 185                 190         


Val Thr Glu Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro 
        195                 200                 205             


Asp Val Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys 
    210                 215                 220                 


Thr Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
225                 230                 235                 240 


Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr Val 
                245                 250                 255     


Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys 
            260                 265                 270         


Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn Thr Met Glu 
        275                 280                 285             


Arg Glu Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys Ile His Ile Pro 
    290                 295                 300                 


Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys Ser Ser Lys Thr Ser 
305                 310                 315                 320 


Ser Cys Asp Lys Ser Asp Thr Cys Phe 
                325                 


<210>  23
<211>  435
<212>  DNA
<213>  Homo sapiens

<400>  23
atgtggctgc agagcctgct gctcttgggc actgtggcct gcagcatctc tgcacccgcc       60

cgctcgccca gccccagcac gcagccctgg gagcatgtga atgccatcca ggaggcccgg      120

cgtctcctga acctgagtag agacactgct gctgagatga atgaaacagt agaagtcatc      180

tcagaaatgt ttgacctcca ggagccgacc tgcctacaga cccgcctgga gctgtacaag      240

cagggcctgc ggggcagcct caccaagctc aagggcccct tgaccatgat ggccagccac      300

tacaagcagc actgccctcc aaccccggaa acttcctgtg caacccagat tatcaccttt      360

gaaagtttca aagagaacct gaaggacttt ctgcttgtca tcccctttga ctgctgggag      420

ccagtccagg agtga                                                       435


<210>  24
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


