                         SEQUENCE LISTING

<110>  EnClear Therapies, Inc.
 
<120>  METHODS OF TREATING NEUROLOGICAL DISORDERS

<130>  ECT-003WO

<150>  62/702,188
<151>  2018-07-23

<150>  62/702,191
<151>  2018-07-23

<150>  62/815,123
<151>  2019-03-07

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  224
<212>  PRT
<213>  Bos taurus

<400>  1

Ile Val Gly Gly Tyr Thr Cys Ala Glu Asn Ser Val Pro Tyr Gln Val 
1               5                   10                  15      


Ser Leu Asn Ala Gly Tyr His Phe Cys Gly Gly Ser Leu Ile Asn Asp 
            20                  25                  30          


Gln Trp Val Val Ser Ala Ala His Cys Tyr Gln Tyr His Ile Gln Val 
        35                  40                  45              


Arg Leu Gly Glu Tyr Asn Ile Asp Val Leu Glu Gly Gly Glu Gln Phe 
    50                  55                  60                  


Ile Asp Ala Ser Lys Ile Ile Arg His Pro Lys Tyr Ser Ser Trp Thr 
65                  70                  75                  80  


Leu Asp Asn Asp Ile Leu Leu Ile Lys Leu Ser Thr Pro Ala Val Ile 
                85                  90                  95      


Asn Ala Arg Val Ser Thr Leu Leu Leu Pro Ser Ala Cys Ala Ser Ala 
            100                 105                 110         


Gly Thr Glu Cys Leu Ile Ser Gly Trp Gly Asn Thr Leu Ser Ser Gly 
        115                 120                 125             


Val Asn Tyr Pro Asp Leu Leu Gln Cys Leu Val Ala Pro Leu Leu Ser 
    130                 135                 140                 


His Ala Asp Cys Glu Ala Ser Tyr Pro Gly Gln Ile Thr Asn Asn Met 
145                 150                 155                 160 


Ile Cys Ala Gly Phe Leu Glu Gly Gly Lys Asp Ser Cys Gln Gly Asp 
                165                 170                 175     


Ser Gly Gly Pro Val Ala Cys Asn Gly Gln Leu Gln Gly Ile Val Ser 
            180                 185                 190         


Trp Gly Tyr Gly Cys Ala Gln Lys Gly Lys Pro Gly Val Tyr Thr Lys 
        195                 200                 205             


Val Cys Asn Tyr Val Asp Trp Ile Gln Glu Thr Ile Ala Ala Asn Ser 
    210                 215                 220                 


<210>  2
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  2

Ile Val Gly Gly Tyr Thr Cys Glu Glu Asn Ser Val Pro Tyr Gln Val 
1               5                   10                  15      


Ser Leu Asn Ser Gly Ser His Phe Cys Gly Gly Ser Leu Ile Ser Glu 
            20                  25                  30          


Gln Trp Val Val Ser Ala Gly His Cys Tyr Lys Pro His Ile Gln Val 
        35                  40                  45              


Arg Leu Gly Glu His Asn Ile Glu Val Leu Glu Gly Asn Glu Gln Phe 
    50                  55                  60                  


Ile Asn Ala Ala Lys Ile Ile Arg His Pro Lys Tyr Asn Arg Ile Thr 
65                  70                  75                  80  


Leu Asn Asn Asp Ile Met Leu Ile Lys Leu Ser Thr Pro Ala Val Ile 
                85                  90                  95      


Asn Ala His Val Ser Thr Ile Ser Leu Pro Thr Ala Pro Pro Ala Ala 
            100                 105                 110         


Gly Thr Glu Cys Leu Ile Ser Gly Trp Gly Asn Thr Leu Ser Ser Gly 
        115                 120                 125             


Ala Asp Tyr Pro Asp Glu Leu Gln Cys Leu Asp Ala Pro Val Leu Thr 
    130                 135                 140                 


Gln Ala Lys Cys Lys Ala Ser Tyr Pro Leu Lys Ile Thr Ser Lys Met 
145                 150                 155                 160 


Phe Cys Val Gly Phe Leu Glu Gly Gly Lys Asp Ser Cys Gln Gly Asp 
                165                 170                 175     


Ser Gly Gly Pro Val Val Cys Asn Gly Gln Leu Gln Gly Ile Val Ser 
            180                 185                 190         


Trp Gly Tyr Gly Cys Ala Gln Lys Arg Arg Pro Gly Val Tyr Thr Lys 
        195                 200                 205             


Val Tyr Asn Tyr Val Asp Trp Ile Lys Asp Thr Ile Ala Ala Asn Ser 
    210                 215                 220                 


<210>  3
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  3

Ile Val Gly Gly Tyr Asn Cys Glu Glu Asn Ser Val Pro Tyr Gln Val 
1               5                   10                  15      


Ser Leu Asn Ser Gly Tyr His Phe Cys Gly Gly Ser Leu Ile Asn Glu 
            20                  25                  30          


Gln Trp Val Val Ser Ala Gly His Cys Tyr Lys Ser Arg Ile Gln Val 
        35                  40                  45              


Arg Leu Gly Glu His Asn Ile Glu Val Leu Glu Gly Asn Glu Gln Phe 
    50                  55                  60                  


Ile Asn Ala Ala Lys Ile Ile Arg His Pro Gln Tyr Asp Arg Lys Thr 
65                  70                  75                  80  


Leu Asp Asn Asp Ile Leu Leu Ile Lys Leu Ser Ser Pro Ala Val Ile 
                85                  90                  95      


Asn Ser Arg Val Ser Ala Ile Ser Leu Pro Thr Ala Pro Pro Ala Ala 
            100                 105                 110         


Gly Thr Glu Ser Leu Ile Ser Gly Trp Gly Asn Thr Leu Ser Ser Gly 
        115                 120                 125             


Ala Asp Tyr Pro Asp Glu Leu Gln Cys Leu Asp Ala Pro Val Leu Ser 
    130                 135                 140                 


Gln Ala Glu Cys Glu Ala Ser Tyr Pro Gly Lys Ile Thr Asn Asn Met 
145                 150                 155                 160 


Phe Cys Val Gly Phe Leu Glu Gly Gly Lys Asp Ser Cys Gln Gly Asp 
                165                 170                 175     


Ser Gly Gly Pro Val Val Ser Asn Gly Glu Leu Gln Gly Ile Val Ser 
            180                 185                 190         


Trp Gly Tyr Gly Cys Ala Gln Lys Asn Arg Pro Gly Val Tyr Thr Lys 
        195                 200                 205             


Val Tyr Asn Tyr Val Asp Trp Ile Lys Asp Thr Ile Ala Ala Asn Ser 
    210                 215                 220                 


<210>  4
<211>  240
<212>  PRT
<213>  Sus scrofa

<400>  4

Val Val Gly Gly Thr Glu Ala Gln Arg Asn Ser Trp Pro Ser Gln Ile 
1               5                   10                  15      


Ser Leu Gln Tyr Arg Ser Gly Ser Ser Trp Ala His Thr Cys Gly Gly 
            20                  25                  30          


Thr Leu Ile Arg Gln Asn Trp Val Met Thr Ala Ala His Cys Val Asp 
        35                  40                  45              


Arg Glu Leu Thr Phe Arg Val Val Val Gly Glu His Asn Leu Asn Gln 
    50                  55                  60                  


Asn Asn Gly Thr Glu Gln Tyr Val Gly Val Gln Lys Ile Val Val His 
65                  70                  75                  80  


Pro Tyr Trp Asn Thr Asp Asp Val Ala Ala Gly Tyr Asp Ile Ala Leu 
                85                  90                  95      


Leu Arg Leu Ala Gln Ser Val Thr Leu Asn Ser Tyr Val Gln Leu Gly 
            100                 105                 110         


Val Leu Pro Arg Ala Gly Thr Ile Leu Ala Asn Asn Ser Pro Cys Tyr 
        115                 120                 125             


Ile Thr Gly Trp Gly Leu Thr Arg Thr Asn Gly Gln Leu Ala Gln Thr 
    130                 135                 140                 


Leu Gln Gln Ala Tyr Leu Pro Thr Val Asp Tyr Ala Ile Cys Ser Ser 
145                 150                 155                 160 


Ser Ser Tyr Trp Gly Ser Thr Val Lys Asn Ser Met Val Cys Ala Gly 
                165                 170                 175     


Gly Asp Gly Val Arg Ser Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu 
            180                 185                 190         


His Cys Leu Val Asn Gly Gln Tyr Ala Val His Gly Val Thr Ser Phe 
        195                 200                 205             


Val Ser Arg Leu Gly Cys Asn Val Thr Arg Lys Pro Thr Val Phe Thr 
    210                 215                 220                 


Arg Val Ser Ala Tyr Ile Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
225                 230                 235                 240 


<210>  5
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  5

Val Val Gly Gly Thr Glu Ala Gly Arg Asn Ser Trp Pro Ser Gln Ile 
1               5                   10                  15      


Ser Leu Gln Tyr Arg Ser Gly Gly Ser Arg Tyr His Thr Cys Gly Gly 
            20                  25                  30          


Thr Leu Ile Arg Gln Asn Trp Val Met Thr Ala Ala His Cys Val Asp 
        35                  40                  45              


Tyr Gln Lys Thr Phe Arg Val Val Ala Gly Asp His Asn Leu Ser Gln 
    50                  55                  60                  


Asn Asp Gly Thr Glu Gln Tyr Val Ser Val Gln Lys Ile Val Val His 
65                  70                  75                  80  


Pro Tyr Trp Asn Ser Asp Asn Val Ala Ala Gly Tyr Asp Ile Ala Leu 
                85                  90                  95      


Leu Arg Leu Ala Gln Ser Val Thr Leu Asn Ser Tyr Val Gln Leu Gly 
            100                 105                 110         


Val Leu Pro Gln Glu Gly Ala Ile Leu Ala Asn Asn Ser Pro Cys Tyr 
        115                 120                 125             


Ile Thr Gly Trp Gly Lys Thr Lys Thr Asn Gly Gln Leu Ala Gln Thr 
    130                 135                 140                 


Leu Gln Gln Ala Tyr Leu Pro Ser Val Asp Tyr Ala Ile Cys Ser Ser 
145                 150                 155                 160 


Ser Ser Tyr Trp Gly Ser Thr Val Lys Asn Thr Met Val Cys Ala Gly 
                165                 170                 175     


Gly Asp Gly Val Arg Ser Gly Cys Gln Gly Asp Ser Gly Gly Pro Leu 
            180                 185                 190         


His Cys Leu Val Asn Gly Lys Tyr Ser Val His Gly Val Thr Ser Phe 
        195                 200                 205             


Val Ser Ser Arg Gly Cys Asn Val Ser Arg Lys Pro Thr Val Phe Thr 
    210                 215                 220                 


Gln Val Ser Ala Tyr Ile Ser Trp Ile Asn Asn Val Ile Ala Ser Asn 
225                 230                 235                 240 


<210>  6
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  6

Val Val Gly Gly Glu Glu Ala Arg Pro Asn Ser Trp Pro Trp Gln Val 
1               5                   10                  15      


Ser Leu Gln Tyr Ser Ser Asn Gly Lys Trp Tyr His Thr Cys Gly Gly 
            20                  25                  30          


Ser Leu Ile Ala Asn Ser Trp Val Leu Thr Ala Ala His Cys Ile Ser 
        35                  40                  45              


Ser Ser Arg Thr Tyr Arg Val Gly Leu Gly Arg His Asn Leu Tyr Val 
    50                  55                  60                  


Ala Glu Ser Gly Ser Leu Ala Val Ser Val Ser Lys Ile Val Val His 
65                  70                  75                  80  


Lys Asp Trp Asn Ser Asn Gln Ile Ser Lys Gly Asn Asp Ile Ala Leu 
                85                  90                  95      


Leu Lys Leu Ala Asn Pro Val Ser Leu Thr Asp Lys Ile Gln Leu Ala 
            100                 105                 110         


Cys Leu Pro Pro Ala Gly Thr Ile Leu Pro Asn Asn Tyr Pro Cys Tyr 
        115                 120                 125             


Val Thr Gly Trp Gly Arg Leu Gln Thr Asn Gly Ala Val Pro Asp Val 
    130                 135                 140                 


Leu Gln Gln Gly Arg Leu Leu Val Val Asp Tyr Ala Thr Cys Ser Ser 
145                 150                 155                 160 


Ser Ala Trp Trp Gly Ser Ser Val Lys Thr Ser Met Ile Cys Ala Gly 
                165                 170                 175     


Gly Asp Gly Val Ile Ser Ser Cys Asn Gly Asp Ser Gly Gly Pro Leu 
            180                 185                 190         


Asn Cys Gln Ala Ser Asp Gly Arg Trp Gln Val His Gly Ile Val Ser 
        195                 200                 205             


Phe Gly Ser Arg Leu Gly Cys Asn Tyr Tyr His Lys Pro Ser Val Phe 
    210                 215                 220                 


Thr Arg Val Ser Asn Tyr Ile Asp Trp Ile Asn Ser Val Ile Ala Asn 
225                 230                 235                 240 


Asn 
    


<210>  7
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Leu Gly Gly Glu Glu Ala Arg Pro Asn Ser Trp Pro Trp Gln Val 
1               5                   10                  15      


Ser Leu Gln Tyr Ser Ser Asn Gly Gln Trp Tyr His Thr Cys Gly Gly 
            20                  25                  30          


Ser Leu Ile Ala Asn Ser Trp Val Leu Thr Ala Ala His Cys Ile Ser 
        35                  40                  45              


Ser Ser Gly Ile Tyr Arg Val Met Leu Gly Gln His Asn Leu Tyr Val 
    50                  55                  60                  


Ala Glu Ser Gly Ser Leu Ala Val Ser Val Ser Lys Ile Val Val His 
65                  70                  75                  80  


Lys Asp Trp Asn Ser Asp Gln Val Ser Lys Gly Asn Asp Ile Ala Leu 
                85                  90                  95      


Leu Lys Leu Ala Asn Pro Val Ser Leu Thr Asp Lys Ile Gln Leu Ala 
            100                 105                 110         


Cys Leu Pro Pro Ala Gly Thr Ile Leu Pro Asn Asn Tyr Pro Cys Tyr 
        115                 120                 125             


Val Thr Gly Trp Gly Arg Leu Gln Thr Asn Gly Ala Leu Pro Asp Asp 
    130                 135                 140                 


Leu Lys Gln Gly Gln Leu Leu Val Val Asp Tyr Ala Thr Cys Ser Ser 
145                 150                 155                 160 


Ser Gly Trp Trp Gly Ser Thr Val Lys Thr Asn Met Ile Cys Ala Gly 
                165                 170                 175     


Gly Asp Gly Val Ile Cys Thr Cys Asn Gly Asp Ser Gly Gly Pro Leu 
            180                 185                 190         


Asn Cys Gln Ala Ser Asp Gly Arg Trp Glu Val His Gly Ile Gly Ser 
        195                 200                 205             


Leu Thr Ser Val Leu Gly Cys Asn Tyr Tyr Tyr Lys Pro Ser Ile Phe 
    210                 215                 220                 


Thr Arg Val Ser Asn Tyr Asn Asp Trp Ile Asn Ser Val Ile Ala Asn 
225                 230                 235                 240 


Asn 
    


<210>  8
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  8

Val Val His Gly Glu Asp Ala Val Pro Tyr Ser Trp Pro Trp Gln Val 
1               5                   10                  15      


Ser Leu Gln Tyr Glu Lys Ser Gly Ser Phe Tyr His Thr Cys Gly Gly 
            20                  25                  30          


Ser Leu Ile Ala Pro Asp Trp Val Val Thr Ala Gly His Cys Ile Ser 
        35                  40                  45              


Arg Asp Leu Thr Tyr Gln Val Val Leu Gly Glu Tyr Asn Leu Ala Val 
    50                  55                  60                  


Lys Glu Gly Pro Glu Gln Val Ile Pro Ile Asn Ser Glu Glu Leu Phe 
65                  70                  75                  80  


Val His Pro Leu Trp Asn Arg Ser Cys Val Ala Cys Gly Asn Asp Ile 
                85                  90                  95      


Ala Leu Ile Lys Leu Ser Arg Ser Ala Gln Leu Gly Asp Ala Val Gln 
            100                 105                 110         


Leu Ala Ser Leu Pro Pro Ala Gly Asp Ile Leu Pro Asn Lys Thr Pro 
        115                 120                 125             


Cys Tyr Ile Thr Gly Trp Gly Arg Leu Tyr Thr Asn Gly Pro Leu Pro 
    130                 135                 140                 


Asp Lys Leu Gln Gln Ala Arg Leu Pro Val Val Asp Tyr Lys His Cys 
145                 150                 155                 160 


Ser Arg Trp Asn Trp Trp Gly Ser Thr Val Lys Lys Thr Met Val Cys 
                165                 170                 175     


Ala Gly Gly Tyr Ile Arg Ser Gly Cys Asn Gly Asp Ser Gly Gly Pro 
            180                 185                 190         


Leu Asn Cys Pro Thr Glu Asp Gly Gly Trp Gln Val His Gly Val Thr 
        195                 200                 205             


Ser Phe Val Ser Ala Phe Gly Cys Asn Phe Ile Trp Lys Pro Thr Val 
    210                 215                 220                 


Phe Thr Arg Val Ser Ala Phe Ile Asp Trp Ile Glu Glu Thr Ile Ala 
225                 230                 235                 240 


Ser His 
        


<210>  9
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  9

Val Val Asn Gly Glu Asp Ala Val Pro Tyr Ser Trp Pro Trp Gln Val 
1               5                   10                  15      


Ser Leu Gln Tyr Glu Lys Ser Gly Ser Phe Tyr His Thr Cys Gly Gly 
            20                  25                  30          


Ser Leu Ile Ala Pro Asp Trp Val Val Thr Ala Gly His Cys Ile Ser 
        35                  40                  45              


Ser Ser Arg Thr Tyr Gln Val Val Leu Gly Glu Tyr Asp Arg Ala Val 
    50                  55                  60                  


Lys Glu Gly Pro Glu Gln Val Ile Pro Ile Asn Ser Gly Asp Leu Phe 
65                  70                  75                  80  


Val His Pro Leu Trp Asn Arg Ser Cys Val Ala Cys Gly Asn Asp Ile 
                85                  90                  95      


Ala Leu Ile Lys Leu Ser Arg Ser Ala Gln Leu Gly Asp Ala Val Gln 
            100                 105                 110         


Leu Ala Ser Leu Pro Pro Ala Gly Asp Ile Leu Pro Asn Glu Thr Pro 
        115                 120                 125             


Cys Tyr Ile Thr Gly Trp Gly Arg Leu Tyr Thr Asn Gly Pro Leu Pro 
    130                 135                 140                 


Asp Lys Leu Gln Glu Ala Leu Leu Pro Val Val Asp Tyr Glu His Cys 
145                 150                 155                 160 


Ser Arg Trp Asn Trp Trp Gly Ser Ser Val Lys Lys Thr Met Val Cys 
                165                 170                 175     


Ala Gly Gly Asp Ile Arg Ser Gly Cys Asn Gly Asp Ser Gly Gly Pro 
            180                 185                 190         


Leu Asn Cys Pro Thr Glu Asp Gly Gly Trp Gln Val His Gly Val Thr 
        195                 200                 205             


Ser Phe Val Ser Ala Phe Gly Cys Asn Thr Arg Arg Lys Pro Thr Val 
    210                 215                 220                 


Phe Thr Arg Val Ser Ala Phe Ile Asp Trp Ile Glu Glu Thr Ile Ala 
225                 230                 235                 240 


Ser His 
        


<210>  10
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  10

Gly Pro Ile Pro Glu Val Leu Lys Asn Tyr Met Asp Ala Gln Tyr Tyr 
1               5                   10                  15      


Gly Glu Ile Gly Ile Gly Thr Pro Pro Gln Cys Phe Thr Val Val Phe 
            20                  25                  30          


Asp Thr Gly Ser Ser Asn Leu Trp Val Pro Ser Ile His Cys Lys Leu 
        35                  40                  45              


Leu Asp Ile Ala Cys Trp Ile His His Lys Tyr Asn Ser Asp Lys Ser 
    50                  55                  60                  


Ser Thr Tyr Val Lys Asn Gly Thr Ser Phe Asp Ile His Tyr Gly Ser 
65                  70                  75                  80  


Gly Ser Leu Ser Gly Tyr Leu Ser Gln Asp Thr Val Ser Val Pro Cys 
                85                  90                  95      


Gln Ser 
        


<210>  11
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  11

Leu Gly Gly Val Lys Val Glu Arg Gln Val Phe Gly Glu Ala Thr Lys 
1               5                   10                  15      


Gln Pro Gly Ile Thr Phe Ile Ala Ala Lys Phe Asp Gly Ile Leu Gly 
            20                  25                  30          


Met Ala Tyr Pro Arg Ile Ser Val Asn Asn Val Leu Pro Val Phe Asp 
        35                  40                  45              


Asn Leu Met Gln Gln Lys Leu Val Asp Gln Asn Ile Phe Ser Phe Tyr 
    50                  55                  60                  


Leu Ser Arg Asp Pro Asp Ala Gln Pro Gly Gly Glu Leu Met Leu Gly 
65                  70                  75                  80  


Gly Thr Asp Ser Lys Tyr Tyr Lys Gly Ser Leu Ser Tyr Leu Asn Val 
                85                  90                  95      


Thr Arg Lys Ala Tyr Trp Gln Val His Leu Asp Gln Val Glu Val Ala 
            100                 105                 110         


Ser Gly Leu Thr Leu Cys Lys Glu Gly Cys Glu Ala Ile Val Asp Thr 
        115                 120                 125             


Gly Thr Ser Leu Met Val Gly Pro Val Asp Glu Val Arg Glu Leu Gln 
    130                 135                 140                 


Lys Ala Ile Gly Ala Val Pro Leu Ile Gln Gly Glu Tyr Met Ile Pro 
145                 150                 155                 160 


Cys Glu Lys Val Ser Thr Leu Pro Ala Ile Thr Leu Lys Leu Gly Gly 
                165                 170                 175     


Lys Gly Tyr Lys Leu Ser Pro Glu Asp Tyr Thr Leu Lys Val Ser Gln 
            180                 185                 190         


Ala Gly Lys Thr Leu Cys Leu Ser Gly Phe Met Gly Met Asp Ile Pro 
        195                 200                 205             


Pro Pro Ser Gly Pro Leu Trp Ile Leu Gly Asp Val Phe Ile Gly Arg 
    210                 215                 220                 


Tyr Tyr Thr Val Phe Asp Arg Asp Asn Asn Arg Val Gly Phe Ala Glu 
225                 230                 235                 240 


Ala Ala Arg Leu 
                


<210>  12
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  12

Val Thr Glu His Val Leu Ala Asn Asn Asp Val Ser Cys Asp His Pro 
1               5                   10                  15      


Ser Asn Thr Val Pro Ser Gly Ser Asn Gln Asp Leu Gly Ala Gly Ala 
            20                  25                  30          


Gly Glu Asp Ala Arg Ser Asp Asp Ser Ser Ser Arg Ile Ile Asn Gly 
        35                  40                  45              


Ser Asp Cys Asp Met His Thr Gln Pro Trp Gln Ala Ala Leu Leu Leu 
    50                  55                  60                  


Arg Pro Asn Gln Leu Tyr Cys Gly Ala Val Leu Val His Pro Gln Trp 
65                  70                  75                  80  


Leu Leu Thr Ala Ala His Cys Arg Lys Lys Val Phe Arg Val Arg Leu 
                85                  90                  95      


Gly His Tyr Ser Leu Ser Pro Val Tyr Glu Ser Gly Gln Gln Met Phe 
            100                 105                 110         


Gln Gly Val Lys Ser Ile Pro His Pro Gly Tyr Ser His Pro Gly His 
        115                 120                 125             


Ser Asn Asp Leu Met Leu Ile Lys Leu Asn Arg Arg Ile Arg Pro Thr 
    130                 135                 140                 


Lys Asp Val Arg Pro Ile Asn Val Ser Ser His Cys Pro Ser Ala Gly 
145                 150                 155                 160 


Thr Lys Cys Leu Val Ser Gly Trp Gly Thr Thr Lys Ser Pro Gln Val 
                165                 170                 175     


His Phe Pro Lys Val Leu Gln Cys Leu Asn Ile Ser Val Leu Ser Gln 
            180                 185                 190         


Lys Arg Cys Glu Asp Ala Tyr Pro Arg Gln Ile Asp Asp Thr Met Phe 
        195                 200                 205             


Cys Ala Gly Asp Lys Ala Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly 
    210                 215                 220                 


Gly Pro Val Val Cys Asn Gly Ser Leu Gln Gly Leu Val Ser Trp Gly 
225                 230                 235                 240 


Asp Tyr Pro Cys Ala Arg Pro Asn Arg Pro Gly Val Tyr Thr Asn Leu 
                245                 250                 255     


Cys Lys Phe Thr Lys Trp Ile Gln Glu Thr Ile Gln Ala Asn Ser 
            260                 265                 270     


<210>  13
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  13

Leu Val His Gly Gly Pro Cys Asp Lys Thr Ser His Pro Tyr Gln Ala 
1               5                   10                  15      


Ala Leu Tyr Thr Ser Gly His Leu Leu Cys Gly Gly Val Leu Ile His 
            20                  25                  30          


Pro Leu Trp Val Leu Thr Ala Ala His Cys Lys Lys Pro Asn Leu Gln 
        35                  40                  45              


Val Phe Leu Gly Lys His Asn Leu Arg Gln Arg Glu Ser Ser Gln Glu 
    50                  55                  60                  


Gln Ser Ser Val Val Arg Ala Val Ile His Pro Asp Tyr Asp Ala Ala 
65                  70                  75                  80  


Ser His Asp Gln Asp Ile Met Leu Leu Arg Leu Ala Arg Pro Ala Lys 
                85                  90                  95      


Leu Ser Glu Leu Ile Gln Pro Leu Pro Leu Glu Arg Asp Cys Ser Ala 
            100                 105                 110         


Asn Thr Thr Ser Cys His Ile Leu Gly Trp Gly Lys Thr Ala Asp Gly 
        115                 120                 125             


Asp Phe Pro Asp Thr Ile Gln Cys Ala Tyr Ile His Leu Val Ser Arg 
    130                 135                 140                 


Glu Glu Cys Glu His Ala Tyr Pro Gly Gln Ile Thr Gln Asn Met Leu 
145                 150                 155                 160 


Cys Ala Gly Asp Glu Lys Tyr Gly Lys Asp Ser Cys Gln Gly Asp Ser 
                165                 170                 175     


Gly Gly Pro Leu Val Cys Gly Asp His Leu Arg Gly Leu Val Ser Trp 
            180                 185                 190         


Gly Asn Ile Pro Cys Gly Ser Lys Glu Lys Pro Gly Val Tyr Thr Asn 
        195                 200                 205             


Val Cys Arg Tyr Thr Asn Trp Ile Gln Lys Thr Ile Gln Ala Lys 
    210                 215                 220             


