                         SEQUENCE LISTING

<110>  IMCHECK THERAPEUTICS
 
<120>  Anti-BTN3A antibodies and their use in treating cancer or 
       infectious disorders

<130>  BEP180083 EP

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  1

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Arg Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Asn Asn Gly Gly Thr Lys Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Ala Thr Leu Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Glu Asp Asp Tyr Asp Gly Thr Pro Phe Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  2
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Thr Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  3
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  3

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Thr Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  4
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  4

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Arg Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Asn Asn Gly Gly Thr Lys Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Ala Thr Leu Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Glu Asp Asp Tyr Asp Gly Thr Pro Phe Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  5
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  5

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Arg Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Asn Asn Gly Gly Thr Lys Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Ala Thr Leu Thr Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Glu Asp Asp Tyr Asp Gly Thr Pro Phe Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
    210                 215                 220                 


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445             


<210>  6
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Thr Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  7
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Thr Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  8
<211>  1356
<212>  DNA
<213>  Homo sapiens

<400>  8
caggtccaac tggtgcagtc tggggctgaa gtgaagaagc ctggggcttc agtgaagttg       60

tcctgcaagg cttctggcta catcttcacc agatactata tgtattgggt gaagcagagg      120

cctggacaag gccttgagtg gattggagag attaatccta acaatggtgg tactaagttc      180

aatgagaagt tcaagaacag ggccacactg actgtagaca aatccatcag cacagcatac      240

atggagctca gcaggctgag atctgacgac acggcggtct attattgttc aagagaggat      300

gattacgacg ggaccccctt tgctatggac tactggggtc aaggaaccct ggtcaccgtc      360

tcctcagcct ccaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc      420

tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg      480

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag      540

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc      600

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagagagtt      660

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaattcgag      720

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      780

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      840

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      900

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      960

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcctccat cgagaaaacc     1020

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1080

gaagagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1140

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1200

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc     1260

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1320

tacacgcaga agagcctctc cctgtctccg ggttga                               1356


<210>  9
<211>  1347
<212>  DNA
<213>  Homo sapiens

<400>  9
caggtccaac tggtgcagtc tggggctgaa gtgaagaagc ctggggcttc agtgaagttg       60

tcctgcaagg cttctggcta catcttcacc agatactata tgtattgggt gaagcagagg      120

cctggacaag gccttgagtg gattggagag attaatccta acaatggtgg tactaagttc      180

aatgagaagt tcaagaacag ggccacactg actgtagaca aatccatcag cacagcatac      240

atggagctca gcaggctgag atctgacgac acggcggtct attattgttc aagagaggat      300

gattacgacg ggaccccctt tgctatggac tactggggtc aaggaaccct ggtcaccgtc      360

tcctcagctt ccaccaaggg cccatccgtc ttccccctgg cgccctgctc caggagcacc      420

tccgagagca cagccgccct gggctgcctg gtcaaggact acttccccga accggtgacg      480

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag      540

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacg      600

aagacctaca cctgcaatgt agatcacaag cccagcaaca ccaaggtgga caagagagtt      660

gagtccaaat atggtccccc atgcccacca tgcccagcac ctgagttcga ggggggacca      720

tcagtcttcc tgttcccccc aaaacccaag gacactctca tgatctcccg gacccctgag      780

gtcacgtgcg tggtggtgga cgtgagccag gaagaccccg aggtccagtt caactggtac      840

gtggatggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gttcaacagc      900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa cggcaaggag      960

tacaagtgca aggtctccaa caaaggcctc ccgtcctcca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga gccacaggtg tacaccctgc ccccatccca ggaggagatg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctaccccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctacagc aggctaaccg tggacaagag caggtggcag     1260

gaggggaatg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacacag     1320

aagagcctct ccctgtctct gggttga                                         1347


<210>  10
<211>  645
<212>  DNA
<213>  Homo sapiens

<400>  10
gacatccaga tgacccagtc tccatccagt ctgtctgcat ccgtaggaga cagagtcacc       60

atcacttgcc atgccagtca gaacattaat gtttggttat cttggtacca gcagaaacca      120

ggaaaagccc ctaaactctt gatctataag gcttccaact tgcacacagg cgtcccatca      180

agatttactg gcagtggatc tggaacagat ttcacattca ccatcagcag cctgcagcct      240

gaagacattg ccacttacta ctgtcaacag ggtcaaactt atccatacac gttcggacag      300

gggaccaagc tggagatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag                      645


<210>  11
<211>  645
<212>  DNA
<213>  Homo sapiens

<400>  11
gacatccaga tgacccagtc tccatccagt ctgtctgcat ccgtaggaga cagagtcacc       60

atcacttgcc atgccagtca gaacattaat gtttggttat cttggtacca gcagaaacca      120

ggaaaagccc ctaaactctt gatctataag gcttccaact tgcacacagg cgtcccatca      180

agatttagtg gcagtggatc tggaacagat ttcacattca ccatcagcag cctgcagcct      240

gaagacattg ccacttacta ctgtcaacag ggtcaaactt atccatacac gttcggacag      300

gggaccaagc tggagatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag                      645


<210>  12
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  12

Arg Tyr Tyr Met Tyr 
1               5   


<210>  13
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  13

Glu Ile Asn Pro Asn Asn Gly Gly Thr Lys Phe Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asn 
    


<210>  14
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  14

Glu Asp Asp Tyr Asp Gly Thr Pro Phe Ala Met Asp Tyr 
1               5                   10              


<210>  15
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  15

His Ala Ser Gln Asn Ile Asn Val Trp Leu Ser 
1               5                   10      


<210>  16
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  16

Lys Ala Ser Asn Leu His Thr 
1               5           


<210>  17
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  17

Gln Gln Gly Gln Thr Tyr Pro Tyr Thr 
1               5                   


<210>  18
<211>  513
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Lys Met Ala Ser Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val 
1               5                   10                  15      


Cys Leu Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala 
    130                 135                 140                 


Ala Leu Gly Ser Asp Leu His Val Asp Val Lys Gly Tyr Lys Asp Gly 
145                 150                 155                 160 


Gly Ile His Leu Glu Cys Arg Ser Thr Gly Trp Tyr Pro Gln Pro Gln 
                165                 170                 175     


Ile Gln Trp Ser Asn Asn Lys Gly Glu Asn Ile Pro Thr Val Glu Ala 
            180                 185                 190         


Pro Val Val Ala Asp Gly Val Gly Leu Tyr Ala Val Ala Ala Ser Val 
        195                 200                 205             


Ile Met Arg Gly Ser Ser Gly Glu Gly Val Ser Cys Thr Ile Arg Ser 
    210                 215                 220                 


Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro 
225                 230                 235                 240 


Phe Phe Arg Ser Ala Gln Arg Trp Ile Ala Ala Leu Ala Gly Thr Leu 
                245                 250                 255     


Pro Val Leu Leu Leu Leu Leu Gly Gly Ala Gly Tyr Phe Leu Trp Gln 
            260                 265                 270         


Gln Gln Glu Glu Lys Lys Thr Gln Phe Arg Lys Lys Lys Arg Glu Gln 
        275                 280                 285             


Glu Leu Arg Glu Met Ala Trp Ser Thr Met Lys Gln Glu Gln Ser Thr 
    290                 295                 300                 


Arg Val Lys Leu Leu Glu Glu Leu Arg Trp Arg Ser Ile Gln Tyr Ala 
305                 310                 315                 320 


Ser Arg Gly Glu Arg His Ser Ala Tyr Asn Glu Trp Lys Lys Ala Leu 
                325                 330                 335     


Phe Lys Pro Ala Asp Val Ile Leu Asp Pro Lys Thr Ala Asn Pro Ile 
            340                 345                 350         


Leu Leu Val Ser Glu Asp Gln Arg Ser Val Gln Arg Ala Lys Glu Pro 
        355                 360                 365             


Gln Asp Leu Pro Asp Asn Pro Glu Arg Phe Asn Trp His Tyr Cys Val 
    370                 375                 380                 


Leu Gly Cys Glu Ser Phe Ile Ser Gly Arg His Tyr Trp Glu Val Glu 
385                 390                 395                 400 


Val Gly Asp Arg Lys Glu Trp His Ile Gly Val Cys Ser Lys Asn Val 
                405                 410                 415     


Gln Arg Lys Gly Trp Val Lys Met Thr Pro Glu Asn Gly Phe Trp Thr 
            420                 425                 430         


Met Gly Leu Thr Asp Gly Asn Lys Tyr Arg Thr Leu Thr Glu Pro Arg 
        435                 440                 445             


Thr Asn Leu Lys Leu Pro Lys Pro Pro Lys Lys Val Gly Val Phe Leu 
    450                 455                 460                 


Asp Tyr Glu Thr Gly Asp Ile Ser Phe Tyr Asn Ala Val Asp Gly Ser 
465                 470                 475                 480 


His Ile His Thr Phe Leu Asp Val Ser Phe Ser Glu Ala Leu Tyr Pro 
                485                 490                 495     


Val Phe Arg Ile Leu Thr Leu Glu Pro Thr Ala Leu Thr Ile Cys Pro 
            500                 505                 510         


Ala 
    


<210>  19
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Lys Met Ala Ser Ser Leu Ala Phe Leu Leu Leu Asn Phe His Val 
1               5                   10                  15      


Ser Leu Leu Leu Val Gln Leu Leu Thr Pro Cys Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Lys Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala 
    130                 135                 140                 


Ala Leu Gly Ser Asn Leu His Val Glu Val Lys Gly Tyr Glu Asp Gly 
145                 150                 155                 160 


Gly Ile His Leu Glu Cys Arg Ser Thr Gly Trp Tyr Pro Gln Pro Gln 
                165                 170                 175     


Ile Gln Trp Ser Asn Ala Lys Gly Glu Asn Ile Pro Ala Val Glu Ala 
            180                 185                 190         


Pro Val Val Ala Asp Gly Val Gly Leu Tyr Glu Val Ala Ala Ser Val 
        195                 200                 205             


Ile Met Arg Gly Gly Ser Gly Glu Gly Val Ser Cys Ile Ile Arg Asn 
    210                 215                 220                 


Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro 
225                 230                 235                 240 


Phe Phe Arg Ser Ala Gln Pro Trp Ile Ala Ala Leu Ala Gly Thr Leu 
                245                 250                 255     


Pro Ile Leu Leu Leu Leu Leu Ala Gly Ala Ser Tyr Phe Leu Trp Arg 
            260                 265                 270         


Gln Gln Lys Glu Ile Thr Ala Leu Ser Ser Glu Ile Glu Ser Glu Gln 
        275                 280                 285             


Glu Met Lys Glu Met Gly Tyr Ala Ala Thr Glu Arg Glu Ile Ser Leu 
    290                 295                 300                 


Arg Glu Ser Leu Gln Glu Glu Leu Lys Arg Lys Lys Ile Gln Tyr Leu 
305                 310                 315                 320 


Thr Arg Gly Glu Glu Ser Ser Ser Asp Thr Asn Lys Ser Ala 
                325                 330                 


<210>  20
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Lys Met Ala Ser Ser Leu Ala Phe Leu Leu Leu Asn Phe His Val 
1               5                   10                  15      


Ser Leu Phe Leu Val Gln Leu Leu Thr Pro Cys Ser Ala Gln Phe Ser 
            20                  25                  30          


Val Leu Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala 
        35                  40                  45              


Asp Leu Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu 
    50                  55                  60                  


Leu Arg Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Gly Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg 
                85                  90                  95      


Thr Ser Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg 
            100                 105                 110         


Ile His Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe 
        115                 120                 125             


Gln Asp Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala 
    130                 135                 140                 


Ala Leu Gly Ser Asp Leu His Ile Glu Val Lys Gly Tyr Glu Asp Gly 
145                 150                 155                 160 


Gly Ile His Leu Glu Cys Arg Ser Thr Gly Trp Tyr Pro Gln Pro Gln 
                165                 170                 175     


Ile Lys Trp Ser Asp Thr Lys Gly Glu Asn Ile Pro Ala Val Glu Ala 
            180                 185                 190         


Pro Val Val Ala Asp Gly Val Gly Leu Tyr Ala Val Ala Ala Ser Val 
        195                 200                 205             


Ile Met Arg Gly Ser Ser Gly Gly Gly Val Ser Cys Ile Ile Arg Asn 
    210                 215                 220                 


Ser Leu Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp Pro 
225                 230                 235                 240 


Phe Phe Arg Ser Ala Gln Pro Trp Ile Ala Ala Leu Ala Gly Thr Leu 
                245                 250                 255     


Pro Ile Ser Leu Leu Leu Leu Ala Gly Ala Ser Tyr Phe Leu Trp Arg 
            260                 265                 270         


Gln Gln Lys Glu Lys Ile Ala Leu Ser Arg Glu Thr Glu Arg Glu Arg 
        275                 280                 285             


Glu Met Lys Glu Met Gly Tyr Ala Ala Thr Glu Gln Glu Ile Ser Leu 
    290                 295                 300                 


Arg Glu Lys Leu Gln Glu Glu Leu Lys Trp Arg Lys Ile Gln Tyr Met 
305                 310                 315                 320 


Ala Arg Gly Glu Lys Ser Leu Ala Tyr His Glu Trp Lys Met Ala Leu 
                325                 330                 335     


Phe Lys Pro Ala Asp Val Ile Leu Asp Pro Asp Thr Ala Asn Ala Ile 
            340                 345                 350         


Leu Leu Val Ser Glu Asp Gln Arg Ser Val Gln Arg Ala Glu Glu Pro 
        355                 360                 365             


Arg Asp Leu Pro Asp Asn Pro Glu Arg Phe Glu Trp Arg Tyr Cys Val 
    370                 375                 380                 


Leu Gly Cys Glu Asn Phe Thr Ser Gly Arg His Tyr Trp Glu Val Glu 
385                 390                 395                 400 


Val Gly Asp Arg Lys Glu Trp His Ile Gly Val Cys Ser Lys Asn Val 
                405                 410                 415     


Glu Arg Lys Lys Gly Trp Val Lys Met Thr Pro Glu Asn Gly Tyr Trp 
            420                 425                 430         


Thr Met Gly Leu Thr Asp Gly Asn Lys Tyr Arg Ala Leu Thr Glu Pro 
        435                 440                 445             


Arg Thr Asn Leu Lys Leu Pro Glu Pro Pro Arg Lys Val Gly Ile Phe 
    450                 455                 460                 


Leu Asp Tyr Glu Thr Gly Glu Ile Ser Phe Tyr Asn Ala Thr Asp Gly 
465                 470                 475                 480 


Ser His Ile Tyr Thr Phe Pro His Ala Ser Phe Ser Glu Pro Leu Tyr 
                485                 490                 495     


Pro Val Phe Arg Ile Leu Thr Leu Glu Pro Thr Ala Leu Thr Ile Cys 
            500                 505                 510         


Pro Ile Pro Lys Glu Val Glu Ser Ser Pro Asp Pro Asp Leu Val Pro 
        515                 520                 525             


Asp His Ser Leu Glu Thr Pro Leu Thr Pro Gly Leu Ala Asn Glu Ser 
    530                 535                 540                 


Gly Glu Pro Gln Ala Glu Val Thr Ser Leu Leu Leu Pro Ala His Pro 
545                 550                 555                 560 


Gly Ala Glu Val Ser Pro Ser Ala Thr Thr Asn Gln Asn His Lys Leu 
                565                 570                 575     


Gln Ala Arg Thr Glu Ala Leu Tyr 
            580                 


<210>  21
<211>  243
<212>  PRT
<213>  Macaca fascicularis

<400>  21

Met Gly Ser Ser Leu Ala Phe Leu Leu Leu Ser Phe His Val Cys Val 
1               5                   10                  15      


Leu Leu Leu Gln Leu Leu Met Pro His Ser Ala Gln Phe Ala Val Val 
            20                  25                  30          


Gly Pro Pro Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala Asp Leu 
        35                  40                  45              


Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu Leu Arg 
    50                  55                  60                  


Trp Val Ser Ser Asn Leu Arg Gln Val Val Asn Val Tyr Ala Asp Gly 
65                  70                  75                  80  


Lys Glu Val Glu Asp Arg Gln Ser Ala Ala Tyr Arg Gly Arg Thr Ser 
                85                  90                  95      


Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg Ile His 
            100                 105                 110         


Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe Gln Asp 
        115                 120                 125             


Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala Ala Leu 
    130                 135                 140                 


Gly Ser Asp Leu His Ile Asp Val Lys Gly Tyr Glu Asp Gly Gly Ile 
145                 150                 155                 160 


His Leu Glu Cys Arg Ser Thr Gly Trp Tyr Pro Gln Pro Gln Ile Arg 
                165                 170                 175     


Trp Ser Asn Asp Lys Gly Glu Asn Ile Pro Ala Val Glu Ala Pro Val 
            180                 185                 190         


Phe Val Asp Gly Val Gly Leu Tyr Ala Val Ala Ala Ser Val Ile Leu 
        195                 200                 205             


Arg Gly Ser Ser Gly Glu Gly Val Ser Cys Thr Ile Arg Ser Ser Leu 
    210                 215                 220                 


Leu Gly Leu Glu Lys Thr Thr Ser Ile Ser Ile Ala Gly His His His 
225                 230                 235                 240 


His His His 
            


<210>  22
<211>  243
<212>  PRT
<213>  Macaca fascicularis

<400>  22

Met Gly Ser Ser Leu Ala Phe Leu Leu Leu Asn Phe His Val Ser Phe 
1               5                   10                  15      


Phe Leu Val Gln Leu Leu Thr Pro Cys Ser Ala Gln Phe Ser Val Leu 
            20                  25                  30          


Gly Pro Ser Gly Pro Ile Leu Ala Met Val Gly Glu Asp Ala Asp Leu 
        35                  40                  45              


Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu Leu Arg 
    50                  55                  60                  


Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ala Asp Gly 
65                  70                  75                  80  


Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg Thr Ser 
                85                  90                  95      


Ile Leu Arg Asp Asp Ile Ala Ala Gly Lys Ala Ala Leu Arg Ile His 
            100                 105                 110         


Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe Gln Asp 
        115                 120                 125             


Ala Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala Ala Leu 
    130                 135                 140                 


Gly Ser Asn Leu His Val Glu Val Lys Gly Tyr Glu Asp Gly Gly Ile 
145                 150                 155                 160 


His Leu Glu Cys Arg Ser Thr Gly Trp Tyr Pro Gln Pro Lys Ile Gln 
                165                 170                 175     


Trp Ser Asn Ala Lys Gly Gln Asn Ile Pro Ala Val Glu Ala Pro Val 
            180                 185                 190         


Val Ala Asp Gly Val Gly Leu Tyr Ala Val Ala Ala Ser Val Ile Met 
        195                 200                 205             


Arg Gly Gly Ser Gly Glu Ser Val Ser Cys Ile Ile Arg Asn Ser Val 
    210                 215                 220                 


Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile Ala Asp His His His 
225                 230                 235                 240 


His His His 
            


<210>  23
<211>  243
<212>  PRT
<213>  Macaca fascicularis

<400>  23

Met Ala Asn Phe Leu Ala Phe Leu Leu Leu Asn Phe Arg Val Cys Leu 
1               5                   10                  15      


Leu Leu Val Gln Leu Leu Thr Pro Cys Ser Ala Gln Phe Ala Val Leu 
            20                  25                  30          


Gly Pro His Gly Pro Ile Leu Ala Met Val Gly Glu Asp Val Asp Leu 
        35                  40                  45              


Pro Cys His Leu Phe Pro Thr Met Ser Ala Glu Thr Met Glu Leu Arg 
    50                  55                  60                  


Trp Val Ser Ser Ser Leu Arg Gln Val Val Asn Val Tyr Ser Asp Gly 
65                  70                  75                  80  


Lys Glu Val Glu Asp Arg Gln Ser Ala Pro Tyr Arg Gly Arg Thr Ser 
                85                  90                  95      


Ile Leu Arg Asp Gly Ile Thr Ala Gly Lys Ala Ala Leu Arg Ile His 
            100                 105                 110         


Asn Val Thr Ala Ser Asp Ser Gly Lys Tyr Leu Cys Tyr Phe Gln Asp 
        115                 120                 125             


Gly Asp Phe Tyr Glu Lys Ala Leu Val Glu Leu Lys Val Ala Ala Leu 
    130                 135                 140                 


Gly Ser Asp Leu His Ile Glu Val Lys Gly Tyr Glu Asp Gly Gly Ile 
145                 150                 155                 160 


His Leu Glu Cys Arg Ser Thr Gly Trp Tyr Pro Gln Pro Gln Ile Gln 
                165                 170                 175     


Trp Ser Asn Thr Lys Gly Gln His Ile Pro Ala Val Lys Ala Pro Val 
            180                 185                 190         


Val Ala Asp Gly Val Gly Leu Tyr Ala Val Ala Ala Ser Val Ile Met 
        195                 200                 205             


Arg Gly Ser Ser Gly Glu Gly Val Ser Cys Ile Ile Arg Asn Ser Leu 
    210                 215                 220                 


Leu Gly Leu Glu Lys Thr Ala Ser Ile Ser Ile Thr Asp His His His 
225                 230                 235                 240 


His His His 
            


