                         SEQUENCE LISTING

<110>    Washington University        
         NeoImmune Tech, Inc.

<120>    USE OF INTERLEUKIN-7 AND CHIMERIC ANTIGEN RECEPTOR (CAR)-BEARING IMMUNE EFFECTOR CELLS FOR TREATING TUMOR

<130>    4241.003PC03/C-K/DKC 

<150>    US 62/712,803
<151>    2018-07-31

<150>    US 62/804,604
<151>    2019-02-12               

<160>    39

<170>    PatentIn version 3.5

<210>    1
<211>    177
<212>    PRT
<213>    Homo sapiens

<220>
<223>    Amino acid sequence of human IL-7 (Accession number: P13232)


<400>    1
Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile
  1               5                  10                  15 

Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys
             20                  25                  30 

Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu
         35                  40                  45 

Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe
     50                  55                  60 

Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe
 65                  70                  75                  80 

Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser
                 85                  90                  95 

Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr
            100                 105                 110 

Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala
        115                 120                 125 

Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu
    130                 135                 140 

Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu
145                 150                 155                 160 

Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu
                165                 170                 175 

His
   


<210>    2
<211>    154
<212>    PRT
<213>    Rattus norvegicus 

<220>
<223>    amino acid sequence of rat IL-7 (Accession number: P56478)


<400>    2
Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Ile Pro Pro Leu Ile
  1               5                  10                  15 

Leu Val Leu Leu Pro Val Thr Ser Ser Asp Cys His Ile Lys Asp Lys
             20                  25                  30 

Asp Gly Lys Ala Phe Gly Ser Val Leu Met Ile Ser Ile Asn Gln Leu
         35                  40                  45 

Asp Lys Met Thr Gly Thr Asp Ser Asp Cys Pro Asn Asn Glu Pro Asn
     50                  55                  60 

Phe Phe Lys Lys His Leu Cys Asp Asp Thr Lys Glu Ala Ala Phe Leu
 65                  70                  75                  80 

Asn Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ile Ser
                 85                  90                  95 

Glu Glu Phe Asn Asp His Leu Leu Arg Val Ser Asp Gly Thr Gln Thr
            100                 105                 110 

Leu Val Asn Cys Thr Ser Lys Glu Glu Lys Thr Ile Lys Glu Gln Lys
        115                 120                 125 

Lys Asn Asp Pro Cys Phe Leu Lys Arg Leu Leu Arg Glu Ile Lys Thr
    130                 135                 140 

Cys Trp Asn Lys Ile Leu Lys Gly Ser Ile
145                 150                


<210>    3
<211>    154
<212>    PRT
<213>    Mus musculus

<220>
<223>    amino acid sequence of mouse IL-7 (Accession number: P10168)


<400>    3
Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Ile Pro Pro Leu Ile
  1               5                  10                  15 

Leu Val Leu Leu Pro Val Thr Ser Ser Glu Cys His Ile Lys Asp Lys
             20                  25                  30 

Glu Gly Lys Ala Tyr Glu Ser Val Leu Met Ile Ser Ile Asp Glu Leu
         35                  40                  45 

Asp Lys Met Thr Gly Thr Asp Ser Asn Cys Pro Asn Asn Glu Pro Asn
     50                  55                  60 

Phe Phe Arg Lys His Val Cys Asp Asp Thr Lys Glu Ala Ala Phe Leu
 65                  70                  75                  80 

Asn Arg Ala Ala Arg Lys Leu Lys Gln Phe Leu Lys Met Asn Ile Ser
                 85                  90                  95 

Glu Glu Phe Asn Val His Leu Leu Thr Val Ser Gln Gly Thr Gln Thr
            100                 105                 110 

Leu Val Asn Cys Thr Ser Lys Glu Glu Lys Asn Val Lys Glu Gln Lys
        115                 120                 125 

Lys Asn Asp Ala Cys Phe Leu Lys Arg Leu Leu Arg Glu Ile Lys Thr
    130                 135                 140 

Cys Trp Asn Lys Ile Leu Lys Gly Ser Ile
145                 150                


<210>    4
<211>    177
<212>    PRT
<213>    Chlorocebus sabaeus

<220>
<223>    amino acid sequence of monkey IL-7 (Accession number :
         NP_001279008)


<400>    4
Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile
  1               5                  10                  15 

Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys
             20                  25                  30 

Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu
         35                  40                  45 

Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe
     50                  55                  60 

Asn Phe Phe Lys Arg His Leu Cys Asp Asp Asn Lys Glu Gly Met Phe
 65                  70                  75                  80 

Leu Phe Arg Ala Ala Arg Lys Leu Lys Gln Phe Leu Lys Met Asn Ser
                 85                  90                  95 

Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr
            100                 105                 110 

Ile Leu Leu Asn Cys Thr Gly Lys Val Lys Gly Arg Lys Pro Ala Ala
        115                 120                 125 

Leu Gly Glu Pro Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu
    130                 135                 140 

Lys Glu Gln Lys Lys Leu Asn Asp Ser Cys Phe Leu Lys Arg Leu Leu
145                 150                 155                 160 

Gln Lys Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu
                165                 170                 175 

His
   


<210>    5
<211>    176
<212>    PRT
<213>    Bos taurus

<220>
<223>    amino acid sequence of cow IL-7 (Accession number: P26895)


<400>    5
Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Ile Pro Pro Leu Ile
  1               5                  10                  15 

Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Ser Gly Lys
             20                  25                  30 

Asp Gly Gly Ala Tyr Gln Asn Val Leu Met Val Asn Ile Asp Asp Leu
         35                  40                  45 

Asp Asn Met Ile Asn Phe Asp Ser Asn Cys Leu Asn Asn Glu Pro Asn
     50                  55                  60 

Phe Phe Lys Lys His Ser Cys Asp Asp Asn Lys Glu Ala Ser Phe Leu
 65                  70                  75                  80 

Asn Arg Ala Ser Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ile Ser
                 85                  90                  95 

Asp Asp Phe Lys Leu His Leu Ser Thr Val Ser Gln Gly Thr Leu Thr
            100                 105                 110 

Leu Leu Asn Cys Thr Ser Lys Gly Lys Gly Arg Lys Pro Pro Ser Leu
        115                 120                 125 

Ser Glu Ala Gln Pro Thr Lys Asn Leu Glu Glu Asn Lys Ser Ser Lys
    130                 135                 140 

Glu Gln Lys Lys Gln Asn Asp Leu Cys Phe Leu Lys Ile Leu Leu Gln
145                 150                 155                 160 

Lys Ile Lys Thr Cys Trp Asn Lys Ile Leu Arg Gly Ile Lys Glu His
                165                 170                 175 


<210>    6
<211>    176
<212>    PRT
<213>    Ovis aries

<220>
<223>    amino acid sequence of sheep IL-7 (Accession number : Q28540)


<400>    6
Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Ile Pro Pro Leu Ile
  1               5                  10                  15 

Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Phe Ser Gly Lys
             20                  25                  30 

Asp Gly Gly Ala Tyr Gln Asn Val Leu Met Val Ser Ile Asp Asp Leu
         35                  40                  45 

Asp Asn Met Ile Asn Phe Asp Ser Asn Cys Leu Asn Asn Glu Pro Asn
     50                  55                  60 

Phe Phe Lys Lys His Ser Cys Asp Asp Asn Lys Glu Ala Ser Phe Leu
 65                  70                  75                  80 

Asn Arg Ala Ala Arg Lys Leu Lys Gln Phe Leu Lys Met Asn Ile Ser
                 85                  90                  95 

Asp Asp Phe Lys Leu His Leu Ser Thr Val Ser Gln Gly Thr Leu Thr
            100                 105                 110 

Leu Leu Asn Cys Thr Ser Lys Gly Lys Gly Arg Lys Pro Pro Ser Leu
        115                 120                 125 

Gly Glu Ala Gln Pro Thr Lys Asn Leu Glu Glu Asn Lys Ser Leu Lys
    130                 135                 140 

Glu Gln Arg Lys Gln Asn Asp Leu Cys Phe Leu Lys Ile Leu Leu Gln
145                 150                 155                 160 

Lys Ile Lys Thr Cys Trp Asn Lys Ile Leu Arg Gly Ile Thr Glu His
                165                 170                 175 


<210>    7
<211>    384
<212>    PRT
<213>    Homo sapiens

<220>
<223>    amino acid sequence of human IgD constant region (Genbank
         accession No. P01880)


<400>    7
Ala Pro Thr Lys Ala Pro Asp Val Phe Pro Ile Ile Ser Gly Cys Arg
  1               5                  10                  15 

His Pro Lys Asp Asn Ser Pro Val Val Leu Ala Cys Leu Ile Thr Gly
             20                  25                  30 

Tyr His Pro Thr Ser Val Thr Val Thr Trp Tyr Met Gly Thr Gln Ser
         35                  40                  45 

Gln Pro Gln Arg Thr Phe Pro Glu Ile Gln Arg Arg Asp Ser Tyr Tyr
     50                  55                  60 

Met Thr Ser Ser Gln Leu Ser Thr Pro Leu Gln Gln Trp Arg Gln Gly
 65                  70                  75                  80 

Glu Tyr Lys Cys Val Val Gln His Thr Ala Ser Lys Ser Lys Lys Glu
                 85                  90                  95 

Ile Phe Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro
            100                 105                 110 

Thr Ala Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala
        115                 120                 125 

Pro Ala Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys
    130                 135                 140 

Glu Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu
145                 150                 155                 160 

Cys Pro Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala
                165                 170                 175 

Val Gln Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val
            180                 185                 190 

Val Gly Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly
        195                 200                 205 

Lys Val Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser
    210                 215                 220 

Asn Gly Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu
225                 230                 235                 240 

Trp Asn Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu
                245                 250                 255 

Pro Pro Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro
            260                 265                 270 

Val Lys Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala
        275                 280                 285 

Ala Ser Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile
    290                 295                 300 

Leu Leu Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe
305                 310                 315                 320 

Ala Pro Ala Arg Pro Pro Pro Gln Pro Gly Ser Thr Thr Phe Trp Ala
                325                 330                 335 

Trp Ser Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr
            340                 345                 350 

Tyr Thr Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala
        355                 360                 365 

Ser Arg Ser Leu Glu Val Ser Tyr Val Thr Asp His Gly Pro Met Lys
    370                 375                 380 




<210>    8
<211>    327
<212>    PRT
<213>    Homo sapiens

<220>
<223>    amino acid sequence of Partial human IgG4 constant region
         (Genbank accession No. AAH25985)


<400>    8
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
  1               5                  10                  15 

Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
             20                  25                  30 

Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
         35                  40                  45 

Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
     50                  55                  60 

Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr
 65                  70                  75                  80 

Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
                 85                  90                  95 

Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro
            100                 105                 110 

Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
        115                 120                 125 

Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
    130                 135                 140 

Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp
145                 150                 155                 160 

Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe
                165                 170                 175 

Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
            180                 185                 190 

Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu
        195                 200                 205 

Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
    210                 215                 220 

Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys
225                 230                 235                 240 

Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
                245                 250                 255 

Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
            260                 265                 270 

Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
        275                 280                 285 

Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser
    290                 295                 300 

Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
305                 310                 315                 320 

Leu Ser Leu Ser Leu Gly Lys
                325        


<210>    9
<211>    245
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    amino acid sequence of hyFc


<400>    9
Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys
  1               5                  10                  15 

Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro Ser His
             20                  25                  30 

Thr Gln Pro Leu Gly Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
         35                  40                  45 

Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
     50                  55                  60 

Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val
 65                  70                  75                  80 

Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser
                 85                  90                  95 

Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
            100                 105                 110 

Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser
        115                 120                 125 

Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
    130                 135                 140 

Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln
145                 150                 155                 160 

Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
                165                 170                 175 

Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
            180                 185                 190 

Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu
        195                 200                 205 

Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser
    210                 215                 220 

Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
225                 230                 235                 240 

Leu Ser Leu Gly Lys
                245


<210>    10
<211>    245
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    amino acid sequence of hyFcM1


<400>    10
Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Gly Gly Lys Glu Lys
  1               5                  10                  15 

Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro Ser His
             20                  25                  30 

Thr Gln Pro Leu Gly Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
         35                  40                  45 

Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
     50                  55                  60 

Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val
 65                  70                  75                  80 

Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser
                 85                  90                  95 

Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
            100                 105                 110 

Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser
        115                 120                 125 

Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
    130                 135                 140 

Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln
145                 150                 155                 160 

Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
                165                 170                 175 

Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
            180                 185                 190 

Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu
        195                 200                 205 

Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser
    210                 215                 220 

Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
225                 230                 235                 240 

Leu Ser Leu Gly Lys
                245


<210>    11
<211>    245
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    amino acid sequence of hyFcM2


<400>    11
Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Gly Ser Lys Glu Lys
  1               5                  10                  15 

Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro Ser His
             20                  25                  30 

Thr Gln Pro Leu Gly Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
         35                  40                  45 

Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
     50                  55                  60 

Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val
 65                  70                  75                  80 

Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser
                 85                  90                  95 

Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
            100                 105                 110 

Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser
        115                 120                 125 

Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
    130                 135                 140 

Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln
145                 150                 155                 160 

Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
                165                 170                 175 

Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
            180                 185                 190 

Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu
        195                 200                 205 

Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser
    210                 215                 220 

Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
225                 230                 235                 240 

Leu Ser Leu Gly Lys
                245


<210>    12
<211>    245
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    amino acid sequence of hyFcM3


<400>    12
Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Ser Gly Lys Glu Lys
  1               5                  10                  15 

Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro Ser His
             20                  25                  30 

Thr Gln Pro Leu Gly Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
         35                  40                  45 

Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
     50                  55                  60 

Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val
 65                  70                  75                  80 

Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser
                 85                  90                  95 

Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
            100                 105                 110 

Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser
        115                 120                 125 

Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
    130                 135                 140 

Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln
145                 150                 155                 160 

Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
                165                 170                 175 

Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
            180                 185                 190 

Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu
        195                 200                 205 

Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser
    210                 215                 220 

Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
225                 230                 235                 240 

Leu Ser Leu Gly Lys
                245


<210>    13
<211>    245
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    amino acid sequence of hyFcM4


<400>    13
Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Ser Ser Lys Glu Lys
  1               5                  10                  15 

Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro Ser His
             20                  25                  30 

Thr Gln Pro Leu Gly Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
         35                  40                  45 

Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
     50                  55                  60 

Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val
 65                  70                  75                  80 

Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser
                 85                  90                  95 

Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
            100                 105                 110 

Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser
        115                 120                 125 

Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
    130                 135                 140 

Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln
145                 150                 155                 160 

Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
                165                 170                 175 

Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
            180                 185                 190 

Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu
        195                 200                 205 

Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser
    210                 215                 220 

Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
225                 230                 235                 240 

Leu Ser Leu Gly Lys
                245


<210>    14
<211>    243
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    amino acid sequence of mouse IgG Fc variant


<400>    14
Ala Ser Ala Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys
  1               5                  10                  15 

Lys Cys Pro Ala Pro Asn Leu Glu Gly Gly Pro Ser Val Phe Ile Phe
             20                  25                  30 

Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val
         35                  40                  45 

Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile
     50                  55                  60 

Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr
 65                  70                  75                  80 

His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro
                 85                  90                  95 

Ile Gln His Gln Asp Trp Met Ser Gly Lys Ala Phe Ala Cys Ala Val
            100                 105                 110 

Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro
        115                 120                 125 

Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu
    130                 135                 140 

Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp
145                 150                 155                 160 

Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr
                165                 170                 175 

Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser
            180                 185                 190 

Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu
        195                 200                 205 

Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His
    210                 215                 220 

His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys Gly Gly Gly Asn
225                 230                 235                 240 

Ser Gly Ser
           


<210>    15
<211>    153
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    amino acid sequence of modified IL-7(M)


<400>    15
Met Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val
  1               5                  10                  15 

Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly
             20                  25                  30 

Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys
         35                  40                  45 

Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu
     50                  55                  60 

Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu
 65                  70                  75                  80 

Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln
                 85                  90                  95 

Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys
            100                 105                 110 

Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp
        115                 120                 125 

Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn
    130                 135                 140 

Lys Ile Leu Met Gly Thr Lys Glu His
145                 150            


<210>    16
<211>    154
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    amino acid sequence of modified IL-7(MM)


<400>    16
Met Met Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser
  1               5                  10                  15 

Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile
             20                  25                  30 

Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile
         35                  40                  45 

Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys
     50                  55                  60 

Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His
 65                  70                  75                  80 

Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly
                 85                  90                  95 

Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr
            100                 105                 110 

Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn
        115                 120                 125 

Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp
    130                 135                 140 

Asn Lys Ile Leu Met Gly Thr Lys Glu His
145                 150                


<210>    17
<211>    155
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    amino acid sequence of modified IL-7(MMM)


<400>    17
Met Met Met Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu
  1               5                  10                  15 

Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu
             20                  25                  30 

Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His
         35                  40                  45 

Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg
     50                  55                  60 

Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu
 65                  70                  75                  80 

His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr
                 85                  90                  95 

Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro
            100                 105                 110 

Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu
        115                 120                 125 

Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys
    130                 135                 140 

Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His
145                 150                 155


<210>    18
<211>    155
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    amino acid sequence of modified IL-7(MGM)


<400>    18
Met Gly Met Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu
  1               5                  10                  15 

Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu
             20                  25                  30 

Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His
         35                  40                  45 

Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg
     50                  55                  60 

Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu
 65                  70                  75                  80 

His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr
                 85                  90                  95 

Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro
            100                 105                 110 

Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu
        115                 120                 125 

Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys
    130                 135                 140 

Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His
145                 150                 155


<210>    19
<211>    155
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    amino acid sequence of modified IL-7(DDD)


<400>    19
Asp Asp Asp Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu
  1               5                  10                  15 

Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu
             20                  25                  30 

Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His
         35                  40                  45 

Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg
     50                  55                  60 

Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu
 65                  70                  75                  80 

His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr
                 85                  90                  95 

Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro
            100                 105                 110 

Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu
        115                 120                 125 

Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys
    130                 135                 140 

Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His
145                 150                 155


<210>    20
<211>    156
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    amino acid sequence of modified IL-7(MMMM)


<400>    20
Met Met Met Met Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr
  1               5                  10                  15 

Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys
             20                  25                  30 

Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg
         35                  40                  45 

His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala
     50                  55                  60 

Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp
 65                  70                  75                  80 

Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys
                 85                  90                  95 

Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln
            100                 105                 110 

Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys
        115                 120                 125 

Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr
    130                 135                 140 

Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His
145                 150                 155    


<210>    21
<211>    398
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    amino acid sequence of modified IL-7(M) fused hyFc


<400>    21
Met Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val
  1               5                  10                  15 

Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly
             20                  25                  30 

Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys
         35                  40                  45 

Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu
     50                  55                  60 

Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu
 65                  70                  75                  80 

Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln
                 85                  90                  95 

Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys
            100                 105                 110 

Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp
        115                 120                 125 

Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn
    130                 135                 140 

Lys Ile Leu Met Gly Thr Lys Glu His Arg Asn Thr Gly Arg Gly Gly
145                 150                 155                 160 

Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu
                165                 170                 175 

Thr Lys Thr Pro Glu Cys Pro Ser His Thr Gln Pro Leu Gly Val Phe
            180                 185                 190 

Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
        195                 200                 205 

Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val
    210                 215                 220 

Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
225                 230                 235                 240 

Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val
                245                 250                 255 

Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
            260                 265                 270 

Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser
        275                 280                 285 

Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
    290                 295                 300 

Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
305                 310                 315                 320 

Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
                325                 330                 335 

Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp
            340                 345                 350 

Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp
        355                 360                 365 

Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His
    370                 375                 380 

Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
385                 390                 395            


<210>    22
<211>    399
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    amino acid sequence of modified IL-7(MM) fused hyFc


<400>    22
Met Met Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser
  1               5                  10                  15 

Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile
             20                  25                  30 

Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile
         35                  40                  45 

Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys
     50                  55                  60 

Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His
 65                  70                  75                  80 

Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly
                 85                  90                  95 

Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr
            100                 105                 110 

Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn
        115                 120                 125 

Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp
    130                 135                 140 

Asn Lys Ile Leu Met Gly Thr Lys Glu His Arg Asn Thr Gly Arg Gly
145                 150                 155                 160 

Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu Glu Gln Glu Glu Arg
                165                 170                 175 

Glu Thr Lys Thr Pro Glu Cys Pro Ser His Thr Gln Pro Leu Gly Val
            180                 185                 190 

Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
        195                 200                 205 

Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu
    210                 215                 220 

Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys
225                 230                 235                 240 

Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser
                245                 250                 255 

Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys
            260                 265                 270 

Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile
        275                 280                 285 

Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
    290                 295                 300 

Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
305                 310                 315                 320 

Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
                325                 330                 335 

Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
            340                 345                 350 

Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg
        355                 360                 365 

Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
    370                 375                 380 

His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
385                 390                 395                


<210>    23
<211>    400
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    amino acid sequence of modified IL-7(MMM) fused hyFc


<400>    23
Met Met Met Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu
  1               5                  10                  15 

Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu
             20                  25                  30 

Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His
         35                  40                  45 

Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg
     50                  55                  60 

Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu
 65                  70                  75                  80 

His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr
                 85                  90                  95 

Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro
            100                 105                 110 

Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu
        115                 120                 125 

Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys
    130                 135                 140 

Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His Arg Asn Thr Gly Arg
145                 150                 155                 160 

Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu Glu Gln Glu Glu
                165                 170                 175 

Arg Glu Thr Lys Thr Pro Glu Cys Pro Ser His Thr Gln Pro Leu Gly
            180                 185                 190 

Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
        195                 200                 205 

Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro
    210                 215                 220 

Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
225                 230                 235                 240 

Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val
                245                 250                 255 

Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
            260                 265                 270 

Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr
        275                 280                 285 

Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
    290                 295                 300 

Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys
305                 310                 315                 320 

Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
                325                 330                 335 

Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
            340                 345                 350 

Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser
        355                 360                 365 

Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
    370                 375                 380 

Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
385                 390                 395                 400


<210>    24
<211>    400
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    amino acid sequence of modified IL-7(MGM) fused hyFc


<400>    24
Met Gly Met Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu
  1               5                  10                  15 

Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu
             20                  25                  30 

Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His
         35                  40                  45 

Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg
     50                  55                  60 

Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu
 65                  70                  75                  80 

His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr
                 85                  90                  95 

Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro
            100                 105                 110 

Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu
        115                 120                 125 

Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys
    130                 135                 140 

Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His Arg Asn Thr Gly Arg
145                 150                 155                 160 

Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu Glu Gln Glu Glu
                165                 170                 175 

Arg Glu Thr Lys Thr Pro Glu Cys Pro Ser His Thr Gln Pro Leu Gly
            180                 185                 190 

Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
        195                 200                 205 

Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro
    210                 215                 220 

Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
225                 230                 235                 240 

Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val
                245                 250                 255 

Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
            260                 265                 270 

Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr
        275                 280                 285 

Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
    290                 295                 300 

Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys
305                 310                 315                 320 

Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
                325                 330                 335 

Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
            340                 345                 350 

Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser
        355                 360                 365 

Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
    370                 375                 380 

Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
385                 390                 395                 400


<210>    25
<211>    401
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    amino acid sequence of modified IL-7(MMMM) fused hyFc


<400>    25
Met Met Met Met Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr
  1               5                  10                  15 

Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys
             20                  25                  30 

Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg
         35                  40                  45 

His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala
     50                  55                  60 

Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp
 65                  70                  75                  80 

Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys
                 85                  90                  95 

Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln
            100                 105                 110 

Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys
        115                 120                 125 

Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr
    130                 135                 140 

Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His Arg Asn Thr Gly
145                 150                 155                 160 

Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu Glu Gln Glu
                165                 170                 175 

Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro Ser His Thr Gln Pro Leu
            180                 185                 190 

Gly Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
        195                 200                 205 

Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp
    210                 215                 220 

Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
225                 230                 235                 240 

Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val
                245                 250                 255 

Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
            260                 265                 270 

Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys
        275                 280                 285 

Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
    290                 295                 300 

Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr
305                 310                 315                 320 

Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
                325                 330                 335 

Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
            340                 345                 350 

Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys
        355                 360                 365 

Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu
    370                 375                 380 

Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly
385                 390                 395                 400 

Lys
   


<210>    26
<211>    397
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    amino acid sequence of human IL-7 fused hyFc


<400>    26
Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu
  1               5                  10                  15 

Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser
             20                  25                  30 

Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp
         35                  40                  45 

Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg
     50                  55                  60 

Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu
 65                  70                  75                  80 

Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val
                 85                  90                  95 

Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser
            100                 105                 110 

Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu
        115                 120                 125 

Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys
    130                 135                 140 

Ile Leu Met Gly Thr Lys Glu His Arg Asn Thr Gly Arg Gly Gly Glu
145                 150                 155                 160 

Glu Lys Lys Lys Glu Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr
                165                 170                 175 

Lys Thr Pro Glu Cys Pro Ser His Thr Gln Pro Leu Gly Val Phe Leu
            180                 185                 190 

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
        195                 200                 205 

Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln
    210                 215                 220 

Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
225                 230                 235                 240 

Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu
                245                 250                 255 

Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
            260                 265                 270 

Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys
        275                 280                 285 

Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
    290                 295                 300 

Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
305                 310                 315                 320 

Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
                325                 330                 335 

Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
            340                 345                 350 

Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln
        355                 360                 365 

Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
    370                 375                 380 

His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
385                 390                 395        


<210>    27
<211>    395
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    amino acid sequence of human IL-7 fused nonlytic mouse Fc


<400>    27
Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu
  1               5                  10                  15 

Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser
             20                  25                  30 

Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp
         35                  40                  45 

Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg
     50                  55                  60 

Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu
 65                  70                  75                  80 

Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val
                 85                  90                  95 

Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser
            100                 105                 110 

Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu
        115                 120                 125 

Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys
    130                 135                 140 

Ile Leu Met Gly Thr Lys Glu His Ala Ser Ala Glu Pro Arg Gly Pro
145                 150                 155                 160 

Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Glu
                165                 170                 175 

Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu
            180                 185                 190 

Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser
        195                 200                 205 

Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu
    210                 215                 220 

Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr
225                 230                 235                 240 

Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser
                245                 250                 255 

Gly Lys Ala Phe Ala Cys Ala Val Asn Asn Lys Asp Leu Pro Ala Pro
            260                 265                 270 

Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln
        275                 280                 285 

Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val
    290                 295                 300 

Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val
305                 310                 315                 320 

Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu
                325                 330                 335 

Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg
            340                 345                 350 

Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val
        355                 360                 365 

Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg
    370                 375                 380 

Thr Pro Gly Lys Gly Gly Gly Asn Ser Gly Ser
385                 390                 395


<210>    28
<211>    531
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    nucleotide sequence of human IL-7


<400>    28
atgttccacg tgagcttcag gtacatcttc ggcctgccac ccctgatcct ggtgctgctg    60

cctgtggcca gctccgactg cgacatcgag ggaaaagacg gcaagcagta cgaaagcgtg   120

ctgatggtgt ccatcgacca gctgctggat tctatgaagg agattgggag taactgcctg   180

aacaatgagt tcaacttctt caaacggcac atttgtgatg ccaacaagga gggaatgttc   240

ctgtttcggg ccgctagaaa actgaggcag ttcctgaaga tgaacagcac cggagacttt   300

gatctgcatc tgctgaaagt gtctgagggc accacaatcc tgctgaactg cactgggcag   360

gtgaaaggaa ggaagcctgc cgctctggga gaggctcagc caaccaagtc actggaggaa   420

aacaaaagcc tgaaggaaca gaagaaactg aatgacctgt gctttctgaa acggctgctg   480

caggagatca aaacatgttg gaacaagatt ctgatgggca caaaggaaca c            531


<210>    29
<211>    534
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    nucleotide sequence of modified IL-7(M)


<400>    29
atgttccacg tgagcttcag atacatcttc ggcctgcccc ccctgatcct ggtgctgctg    60

cccgtggcca gcagcatgga ctgcgacatc gagggcaagg acggcaagca gtacgagagc   120

gtgctgatgg tgagcatcga ccagctgctg gacagcatga aggagatcgg cagcaactgc   180

ctgaacaacg agttcaactt cttcaagaga cacatctgcg acgccaacaa ggagggcatg   240

ttcctgttca gagccgccag aaagctgaga cagttcctga agatgaacag caccggcgac   300

ttcgacctgc acctgctgaa ggtgagcgag ggcacaacca tcctgctgaa ctgcaccggc   360

caggtgaagg gcagaaagcc cgccgccctg ggcgaggccc agcccaccaa gagcctggag   420

gagaacaaga gcctgaagga gcagaagaag ctgaacgacc tgtgcttcct gaagagactg   480

ctgcaggaga tcaagacctg ctggaacaag atcctgatgg gcaccaagga gcac         534


<210>    30
<211>    537
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    nucleotide sequence of modified IL-7(MM)


<400>    30
atgttccacg tgagcttcag atacatcttc ggcctgcccc ccctgatcct ggtgctgctg    60

cccgtggcca gcagcatgat ggactgcgac atcgagggca aggacggcaa gcagtacgag   120

agcgtgctga tggtgagcat cgaccagctg ctggacagca tgaaggagat cggcagcaac   180

tgcctgaaca acgagttcaa cttcttcaag agacacatct gcgacgccaa caaggagggc   240

atgttcctgt tcagagccgc cagaaagctg agacagttcc tgaagatgaa cagcaccggc   300

gacttcgacc tgcacctgct gaaggtgagc gagggcacaa ccatcctgct gaactgcacc   360

ggccaggtga agggcagaaa gcccgccgcc ctgggcgagg cccagcccac caagagcctg   420

gaggagaaca agagcctgaa ggagcagaag aagctgaacg acctgtgctt cctgaagaga   480

ctgctgcagg agatcaagac ctgctggaac aagatcctga tgggcaccaa ggagcac      537


<210>    31
<211>    540
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    nucleotide sequence of modified IL-7(MMM)


<400>    31
atgttccacg tgagcttcag atacatcttc ggcctgcccc ccctgatcct ggtgctgctg    60

cccgtggcca gcagcatgat gatggactgc gacatcgagg gcaaggacgg caagcagtac   120

gagagcgtgc tgatggtgag catcgaccag ctgctggaca gcatgaagga gatcggcagc   180

aactgcctga acaacgagtt caacttcttc aagagacaca tctgcgacgc caacaaggag   240

ggcatgttcc tgttcagagc cgccagaaag ctgagacagt tcctgaagat gaacagcacc   300

ggcgacttcg acctgcacct gctgaaggtg agcgagggca caaccatcct gctgaactgc   360

accggccagg tgaagggcag aaagcccgcc gccctgggcg aggcccagcc caccaagagc   420

ctggaggaga acaagagcct gaaggagcag aagaagctga acgacctgtg cttcctgaag   480

agactgctgc aggagatcaa gacctgctgg aacaagatcc tgatgggcac caaggagcac   540
                                                               


<210>    32
<211>    540
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    nucleotide sequence of modified IL-7(MGM)


<400>    32
atgttccacg tgagcttcag gtacatcttc ggcctgccac ccctgatcct ggtgctgctg    60

cctgtggcca gctccatggg gatggactgc gacatcgagg gaaaagacgg caagcagtac   120

gaaagcgtgc tgatggtgtc catcgaccag ctgctggatt ctatgaagga gattgggagt   180

aactgcctga acaatgagtt caacttcttc aaacggcaca tttgtgatgc caacaaggag   240

ggaatgttcc tgtttcgggc cgctagaaaa ctgaggcagt tcctgaagat gaacagcacc   300

ggagactttg atctgcatct gctgaaagtg tctgagggca ccacaatcct gctgaactgc   360

actgggcagg tgaaaggaag gaagcctgcc gctctgggag aggctcagcc aaccaagtca   420

ctggaggaaa acaaaagcct gaaggaacag aagaaactga atgacctgtg ctttctgaaa   480

cggctgctgc aggagatcaa aacatgttgg aacaagattc tgatgggcac caaggagcac   540



<210>    33
<211>    540
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    nucleotide sequence of modified IL-7(DDD)


<400>    33
atgttccacg tgagcttcag atacatcttc ggcctgcccc ccctgatcct ggtgctgctg    60

cccgtggcca gcagcgacga tgacgactgc gacatcgagg gcaaggacgg caagcagtac   120

gagagcgtgc tgatggtgag catcgaccag ctgctggaca gcatgaagga gatcggcagc   180

aactgcctga acaacgagtt caacttcttc aagagacaca tctgcgacgc caacaaggag   240

ggcatgttcc tgttcagagc cgccagaaag ctgagacagt tcctgaagat gaacagcacc   300

ggcgacttcg acctgcacct gctgaaggtg agcgagggca caaccatcct gctgaactgc   360

accggccagg tgaagggcag aaagcccgcc gccctgggcg aggcccagcc caccaagagc   420

ctggaggaga acaagagcct gaaggagcag aagaagctga acgacctgtg cttcctgaag   480

agactgctgc aggagatcaa gacctgctgg aacaagatcc tgatgggcac caaggagcac   540



<210>    34
<211>    543
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    nucleotide sequence of modified IL-7(MMMM)


<400>    34
atgttccacg tgagcttcag atacatcttc ggcctgcccc ccctgatcct ggtgctgctg    60

cccgtggcca gcagcatgat gatgatggac tgcgacatcg agggcaagga cggcaagcag   120

tacgagagcg tgctgatggt gagcatcgac cagctgctgg acagcatgaa ggagatcggc   180

agcaactgcc tgaacaacga gttcaacttc ttcaagagac acatctgcga cgccaacaag   240

gagggcatgt tcctgttcag agccgccaga aagctgagac agttcctgaa gatgaacagc   300

accggcgact tcgacctgca cctgctgaag gtgagcgagg gcacaaccat cctgctgaac   360

tgcaccggcc aggtgaaggg cagaaagccc gccgccctgg gcgaggccca gcccaccaag   420

agcctggagg agaacaagag cctgaaggag cagaagaagc tgaacgacct gtgcttcctg   480

aagagactgc tgcaggagat caagacctgc tggaacaaga tcctgatggg caccaaggag   540

cac                                                                 543


<210>    35
<211>    1284
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    nucleotide sequence of modified IL-7(M) fused hyFc


<400>    35
atgttccacg tgagcttcag atacatcttc ggcctgcccc ccctgatcct ggtgctgctg    60

cccgtggcca gcagcatgga ctgcgacatc gagggcaagg acggcaagca gtacgagagc   120

gtgctgatgg tgagcatcga ccagctgctg gacagcatga aggagatcgg cagcaactgc   180

ctgaacaacg agttcaactt cttcaagaga cacatctgcg acgccaacaa ggagggcatg   240

ttcctgttca gagccgccag aaagctgaga cagttcctga agatgaacag caccggcgac   300

ttcgacctgc acctgctgaa ggtgagcgag ggcacaacca tcctgctgaa ctgcaccggc   360

caggtgaagg gcagaaagcc cgccgccctg ggcgaggccc agcccaccaa gagcctggag   420

gagaacaaga gcctgaagga gcagaagaag ctgaacgacc tgtgcttcct gaagagactg   480

ctgcaggaga tcaagacctg ctggaacaag atcctgatgg gcaccaagga gcacaggaac   540

acaggcagag gcggcgagga gaagaagaag gagaaggaga aggaggagca ggaggaaaga   600

gagaccaaga cccccgagtg ccccagccac acccagcccc tgggcgtgtt cctgttccct   660

cccaagccca aggacaccct gatgatcagc agaacccccg aggtgacctg cgtggtcgtg   720

gatgtgagcc aggaagatcc cgaagtgcag ttcaactggt acgtggatgg cgtggaagtg   780

cacaacgcca agaccaagcc cagagaagag cagttcaact ccacctacag agtggtgagc   840

gtgctgaccg tgctgcacca ggactggctg aacggcaagg agtacaagtg caaggtgtcc   900

aacaaaggcc tgcccagctc catcgagaag accatcagca aagccaaagg ccagcccaga   960

gaaccccagg tgtacaccct gcctcccagc caggaagaga tgaccaagaa ccaggtgtcc  1020

ctgacctgcc tggtgaaagg cttctacccc agcgacatcg ccgtggagtg ggaaagcaac  1080

ggccagcccg agaacaatta caagacaacc cctcccgtgc tggatagcga tggcagcttc  1140

tttctgtaca gcagactgac cgtggacaag agcagatggc aggaaggcaa cgtgttcagc  1200

tgcagcgtga tgcacgaagc cctgcacaac cactacaccc agaagagcct gtccctgagc  1260

ctgggcaagt gactcgagtc taga                                         1284


<210>    36
<211>    1272
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    nucleotide sequence of modified IL-7(MM) fused hyFc


<400>    36
atgttccacg tgagcttcag atacatcttc ggcctgcccc ccctgatcct ggtgctgctg    60

cccgtggcca gcagcatgat ggactgcgac atcgagggca aggacggcaa gcagtacgag   120

agcgtgctga tggtgagcat cgaccagctg ctggacagca tgaaggagat cggcagcaac   180

tgcctgaaca acgagttcaa cttcttcaag agacacatct gcgacgccaa caaggagggc   240

atgttcctgt tcagagccgc cagaaagctg agacagttcc tgaagatgaa cagcaccggc   300

gacttcgacc tgcacctgct gaaggtgagc gagggcacaa ccatcctgct gaactgcacc   360

ggccaggtga agggcagaaa gcccgccgcc ctgggcgagg cccagcccac caagagcctg   420

gaggagaaca agagcctgaa ggagcagaag aagctgaacg acctgtgctt cctgaagaga   480

ctgctgcagg agatcaagac ctgctggaac aagatcctga tgggcaccaa ggagcacagg   540

aacacaggca gaggcggcga ggagaagaag aaggagaagg agaaggagga gcaggaggaa   600

agagagacca agacccccga gtgccccagc cacacccagc ccctgggcgt gttcctgttc   660

cctcccaagc ccaaggacac cctgatgatc agcagaaccc ccgaggtgac ctgcgtggtc   720

gtggatgtga gccaggaaga tcccgaagtg cagttcaact ggtacgtgga tggcgtggaa   780

gtgcacaacg ccaagaccaa gcccagagaa gagcagttca actccaccta cagagtggtg   840

agcgtgctga ccgtgctgca ccaggactgg ctgaacggca aggagtacaa gtgcaaggtg   900

tccaacaaag gcctgcccag ctccatcgag aagaccatca gcaaagccaa aggccagccc   960

agagaacccc aggtgtacac cctgcctccc agccaggaag agatgaccaa gaaccaggtg  1020

tccctgacct gcctggtgaa aggcttctac cccagcgaca tcgccgtgga gtgggaaagc  1080

aacggccagc ccgagaacaa ttacaagaca acccctcccg tgctggatag cgatggcagc  1140

ttctttctgt acagcagact gaccgtggac aagagcagat ggcaggaagg caacgtgttc  1200

agctgcagcg tgatgcacga agccctgcac aaccactaca cccagaagag cctgtccctg  1260

agcctgggca ag                                                      1272


<210>    37
<211>    1275
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    nucleotide sequence of modified IL-7(MMM) fused hyFc


<400>    37
atgttccacg tgagcttcag atacatcttc ggcctgcccc ccctgatcct ggtgctgctg    60

cccgtggcca gcagcatgat gatggactgc gacatcgagg gcaaggacgg caagcagtac   120

gagagcgtgc tgatggtgag catcgaccag ctgctggaca gcatgaagga gatcggcagc   180

aactgcctga acaacgagtt caacttcttc aagagacaca tctgcgacgc caacaaggag   240

ggcatgttcc tgttcagagc cgccagaaag ctgagacagt tcctgaagat gaacagcacc   300

ggcgacttcg acctgcacct gctgaaggtg agcgagggca caaccatcct gctgaactgc   360

accggccagg tgaagggcag aaagcccgcc gccctgggcg aggcccagcc caccaagagc   420

ctggaggaga acaagagcct gaaggagcag aagaagctga acgacctgtg cttcctgaag   480

agactgctgc aggagatcaa gacctgctgg aacaagatcc tgatgggcac caaggagcac   540

aggaacacag gcagaggcgg cgaggagaag aagaaggaga aggagaagga ggagcaggag   600

gaaagagaga ccaagacccc cgagtgcccc agccacaccc agcccctggg cgtgttcctg   660

ttccctccca agcccaagga caccctgatg atcagcagaa cccccgaggt gacctgcgtg   720

gtcgtggatg tgagccagga agatcccgaa gtgcagttca actggtacgt ggatggcgtg   780

gaagtgcaca acgccaagac caagcccaga gaagagcagt tcaactccac ctacagagtg   840

gtgagcgtgc tgaccgtgct gcaccaggac tggctgaacg gcaaggagta caagtgcaag   900

gtgtccaaca aaggcctgcc cagctccatc gagaagacca tcagcaaagc caaaggccag   960

cccagagaac cccaggtgta caccctgcct cccagccagg aagagatgac caagaaccag  1020

gtgtccctga cctgcctggt gaaaggcttc taccccagcg acatcgccgt ggagtgggaa  1080

agcaacggcc agcccgagaa caattacaag acaacccctc ccgtgctgga tagcgatggc  1140

agcttctttc tgtacagcag actgaccgtg gacaagagca gatggcagga aggcaacgtg  1200

ttcagctgca gcgtgatgca cgaagccctg cacaaccact acacccagaa gagcctgtcc  1260

ctgagcctgg gcaag                                                   1275


<210>    38
<211>    1275
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    nucleotide sequence of modified IL-7(MGM) fused hyFc


<400>    38
atgttccacg tgagcttcag gtacatcttc ggcctgccac ccctgatcct ggtgctgctg    60

cctgtggcca gctccatggg gatggactgc gacatcgagg gaaaagacgg caagcagtac   120

gaaagcgtgc tgatggtgtc catcgaccag ctgctggatt ctatgaagga gattgggagt   180

aactgcctga acaatgagtt caacttcttc aaacggcaca tttgtgatgc caacaaggag   240

ggaatgttcc tgtttcgggc cgctagaaaa ctgaggcagt tcctgaagat gaacagcacc   300

ggagactttg atctgcatct gctgaaagtg tctgagggca ccacaatcct gctgaactgc   360

actgggcagg tgaaaggaag gaagcctgcc gctctgggag aggctcagcc aaccaagtca   420

ctggaggaaa acaaaagcct gaaggaacag aagaaactga atgacctgtg ctttctgaaa   480

cggctgctgc aggagatcaa aacatgttgg aacaagattc tgatgggcac aaaggaacac   540

cgcaatactg ggcggggcgg ggaggaaaag aaaaaggaga aggaaaagga ggaacaggag   600

gaaagagaga ctaagacccc agaatgtccc agccatactc agcccctggg ggtgttcctg   660

tttcccccta aacctaagga taccctgatg atcagcagga cacccgaggt gacctgcgtg   720

gtcgtggatg tgagccagga agatcccgaa gtgcagttca actggtacgt ggatggcgtg   780

gaagtgcaca acgccaagac caagcccaga gaagagcagt tcaactccac ctacagagtg   840

gtgagcgtgc tgaccgtgct gcaccaggac tggctgaacg gcaaggagta caagtgcaag   900

gtgtccaaca aaggcctgcc cagctccatc gagaagacca tcagcaaagc caaaggccag   960

cccagagaac cccaggtgta caccctgcct cccagccagg aagagatgac caagaaccag  1020

gtgtccctga cctgcctggt gaaaggcttc taccccagcg acatcgccgt ggagtgggaa  1080

agcaacggcc agcccgagaa caattacaag acaacccctc ccgtgctgga tagcgatggc  1140

agcttctttc tgtacagcag actgaccgtg gacaagagca gatggcagga aggcaacgtg  1200

ttcagctgca gcgtgatgca cgaagccctg cacaaccact acacccagaa gagcctgtcc  1260

ctgagcctgg gcaag                                                   1275


<210>    39
<211>    1278
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    nucleotide sequence of modified IL-7(MMMM) fused hyFc


<400>    39
atgttccacg tgagcttcag atacatcttc ggcctgcccc ccctgatcct ggtgctgctg    60

cccgtggcca gcagcatgat gatgatggac tgcgacatcg agggcaagga cggcaagcag   120

tacgagagcg tgctgatggt gagcatcgac cagctgctgg acagcatgaa ggagatcggc   180

agcaactgcc tgaacaacga gttcaacttc ttcaagagac acatctgcga cgccaacaag   240

gagggcatgt tcctgttcag agccgccaga aagctgagac agttcctgaa gatgaacagc   300

accggcgact tcgacctgca cctgctgaag gtgagcgagg gcacaaccat cctgctgaac   360

tgcaccggcc aggtgaaggg cagaaagccc gccgccctgg gcgaggccca gcccaccaag   420

agcctggagg agaacaagag cctgaaggag cagaagaagc tgaacgacct gtgcttcctg   480

aagagactgc tgcaggagat caagacctgc tggaacaaga tcctgatggg caccaaggag   540

cacaggaaca caggcagagg cggcgaggag aagaagaagg agaaggagaa ggaggagcag   600

gaggaaagag agaccaagac ccccgagtgc cccagccaca cccagcccct gggcgtgttc   660

ctgttccctc ccaagcccaa ggacaccctg atgatcagca gaacccccga ggtgacctgc   720

gtggtcgtgg atgtgagcca ggaagatccc gaagtgcagt tcaactggta cgtggatggc   780

gtggaagtgc acaacgccaa gaccaagccc agagaagagc agttcaactc cacctacaga   840

gtggtgagcg tgctgaccgt gctgcaccag gactggctga acggcaagga gtacaagtgc   900

aaggtgtcca acaaaggcct gcccagctcc atcgagaaga ccatcagcaa agccaaaggc   960

cagcccagag aaccccaggt gtacaccctg cctcccagcc aggaagagat gaccaagaac  1020

caggtgtccc tgacctgcct ggtgaaaggc ttctacccca gcgacatcgc cgtggagtgg  1080

gaaagcaacg gccagcccga gaacaattac aagacaaccc ctcccgtgct ggatagcgat  1140

ggcagcttct ttctgtacag cagactgacc gtggacaaga gcagatggca ggaaggcaac  1200

gtgttcagct gcagcgtgat gcacgaagcc ctgcacaacc actacaccca gaagagcctg  1260

tccctgagcc tgggcaag                                                1278


