                         SEQUENCE LISTING

<110>  The Wistar Institute of Anatomy and Biology
       Weiner, David
 
<120>  OPTIMIZED SYNTHETIC CONSENSUS IMMUNOGENIC COMPOSITIONS TARGETING 
       CHONDROITIN SULFATE PROTEOGLYCAN 4 (CSPG4)

<130>  206194-0030-00WO

<150>  US 62/713,123
<151>  2018-08-01

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  6960
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic consensus CSPG4

<400>  1
cagtctggac ctcgaccccc tctgcccgcc cctgcactgg ccctggctct gaccctggca       60

atgctggcaa gagcctccgc cgcttctttc tttggcgaaa accacctgga ggtgcccgtc      120

gctacagcac tgactgacat cgatctgcag ctgcagttca gcacatccca gccagaggcc      180

ctgctgctgc tggcagcagg ccctgctgac catctgctgc tgcagctgta cagcggaaga      240

ctgcaggtca ggctggtgct gggacaggag gaactgcgac tgcagacacc agccgagact      300

ctgctgtctg atagtgtccc ccacaccgtg gtcctgacag tgtcagacag ctgggccacc      360

ctgtccgtcg atggactgct gaacgcatct gctccagtgc caggagcccc tctggaggtc      420

ccatacggac tgttcgtggg cgggacaggc tctctgggac tgccatatct gcgggggact      480

agtcggcccc tgagaggatg cctgcacgct gcaaccctga atggccgctc cctgctgcga      540

ccactgacac ctgacgtgca tgagggctgt gccgaggaat tttctgctgg ggacgatgtg      600

gcactgggat tctccggacc acactctctg gcagcttttc ctgcctgggg cacccaggat      660

gaagggactc tggagttcac cctgaccaca aggtcccgcc aggctcccct ggcatttcag      720

gccggaggcc gccacggcga cttcatctac gtggatattt ttgaggggca tctgcgggcc      780

gtggtcgaaa aggggcaggg aacagtgctg ctgcacaact ctgtgccagt cgcagacggc      840

cagccccatg aagtgagtgt ccacatcgac gctcatagac tggagatttc agtggatcag      900

taccctaccc ggacaagcaa tagaggggtg ctgtcctatc tggagccaag gggaagcctg      960

ctgctgggcg gcctggacgc agaggcctcc agacacctgc aggaacatag gctgggcctg     1020

gctcccgaag caacaaacgc ctccctgctg gggtgcatgg aggatctgtc tgtgaatgga     1080

cagcgaagag gactgcgaga ggccctgctg actcgaaaca tggcagccgg atgtcggctg     1140

gaggaagagg aatatgagga agacgcttac ggcccttatg aggcattcag caccctggct     1200

cccgaagcat ggcctgccat ggaactgcct gagccatgcg tcccagagcc tggactgcct     1260

cccgtgttcg ccaacttcac ccagctgctg actatctctc cactggtggt cgcagagggc     1320

gggactgctt ggctggaatg gcgacacgtg cagcccaccc tggacctgag cgaggccgaa     1380

ctgcggaaat cccaggtgct gttttctgtc accaggggag ctcgccatgg cgagctggaa     1440

ctggatattc ccggagctca ggcaagaaaa atgttcacac tgctggacgt ggtcaaccga     1500

aaggcccggt ttgtgcacga tggcagtgaa gacacatcag atcagctggt gctggaggtg     1560

agtgtcactg ccagaggccc aatgccctca tgtctgaggc gcgggcagac ctacctgctg     1620

cctatccagg tcaacccagt gaatgaccca cccaggatca ttttcccaca cgggtccctg     1680

atggtcatcc tggagcatac acagaagcca ctgggacccg aggtgttcca ggcctatgac     1740

cccgatagcg cctgcgaggg cctgactttt cagctgctgg gaaccccatc cggactgcca     1800

gtggaacgac gagatcagcc tggcgaacca gcaaccgagt tcagttgtcg cgagctggaa     1860

gccgggtcac tggtgtacgt ccacagagga ggcccagcac aggacctgac cttccgggtg     1920

agcgatggcc tgcaggctag tcctccagca actctgaaag tggtcgccgt gcggcctgct     1980

atccagatta gacatagcac cggactgagg ctggcacagg gctccgctgc acccatcctg     2040

cctgccaacc tgtctgtcga gaccaatgct gtgggccagg acgtgagtgt cctgttcagg     2100

gtgacaggag ccctgcagtt tggagagctg cagaagcagg gagcaggggg agtggaagga     2160

gcagagtggt gggctaccca ggcattccac cagcgagatg tcgagcaggg acgagtgcgg     2220

tacctgagca ccgaccccca gcatcgggca gaagatacag tggagaacct ggccctggag     2280

gtgcaggtcg gacaggaaac actgagtaat ctgtcatttc ccgtcaccat tcagagggcc     2340

acagtgtgga tgctgcgcct ggagcctctg cacacccaga acacacagca ggaggcactg     2400

actaccgccc atctggaagc tactctggag gaagcaggac ctagccctcc caccttccac     2460

tatgaggtgg tccaggctcc acgcaagggc aatctgcagc tgcagggaac tagactgtct     2520

gacggacagg ggtttaccca ggacgatctg caggcaggac gagtgaccta cggagcaaca     2580

gccagagcca gtgaagccgt cgaggatacc ttccggttcc gggtgactgc tccaccccac     2640

ttctctcccc tgtatacttt tcctatccat attggcgggg acccagatgc acccgtgctg     2700

accaacgtcc tgctgtccgt gccagaagga ggcgagggcg tcctgagcgc agaccacctg     2760

ttcgtgaaat ccctgaattc cgcctcttac ctgtatgaag tgatggagcg accacgacat     2820

ggaaggctgg catggcgagg aacccaggac aagacaacta tggtgactag cttcaccaac     2880

gaggatctgc tgcggggcag actggtgtac cagcacgacg attccgaaac cacagaggac     2940

gatatcccct ttgtggctac tagacaggga gagggctctg gggacatggc atgggaggaa     3000

gtccgaggcg tgttccgggt cgctatccag cctgtcaatg atcacgcacc agtgcagaca     3060

attagccgcg tgtttcatgt cgcccgaggg ggaagaaggc tgctgactac cgacgatgtg     3120

gcattcagcg acgccgattc cggatttgcc gacgctcagc tggtgctgac caggaaagat     3180

ctgctgttcg gctccatcgt ggccgtcgac gaacctacca gaccaatcta caggttcaca     3240

caggaggatc tgcgcaagcg ccgagtgctg tttgtccact ccggagcaga ccgaggatgg     3300

attcagctgc aggtgtctga tggccagcat caggcaaccg ccctgctgga agtccaggcc     3360

tctgagccct atctgcgcgt ggctaacggg agctccctgg tggtccctca gggcgggcag     3420

ggaacaatcg acactgccgt gctgcacctg gacacaaatc tggatattcg gagcggagat     3480

gaggtccact accatgtgac tgctggacca cgatggggac agctgctgag agcaggacag     3540

ccagctaccg cattcagtca gcaggacctg ctggatggag ccatcctgta ttcacacaac     3600

ggcagtctgt cacccaggga cactctggcc ttcagcgtcg aggcaggacc tgtgcatacc     3660

gatgccacac tgcaggtgac cattgctctg gaaggacccc tggcacctct gcacctggtc     3720

cagcataaga aaatctacgt gttccagggc gaagccgctg agattcggag agaccagctg     3780

gaagcagccc aggaggctgt gcctccagca gatatcgtgt tttcagtcaa aacccctccc     3840

agcgccggat acctggtcat ggtgagccac ggagccctgg ctgacgaacc acccagcctg     3900

gaccccgtgc agagcttctc ccaggaggca gtcgacgctg gacgagtgct gtatctgcat     3960

tcccggcctg aggcctggtc tgacgctttt agtctggatg tggcttctgg actgggcgca     4020

ccactggaag gggtgctggt cgagctggaa gtgctgcctg ctgcaatccc actggaggcc     4080

cagaatttct ccgtccctga aggaggctct cggaccctgg ctcctccact gctgagagtg     4140

accggcccat actttcccac actgcctgga ctgtccctgc aggtgctgga gccccctcag     4200

cacggcgccc tgcagagaga ggaaggaccc caggacagga cactgagcgc cttcagctgg     4260

agagaagtcg aggaacagct gattcgctat gtgcacgacg gcagtgagac tctgaccgat     4320

tcattcgtgc tggtcgcaaa cgccagcgaa atggaccggc agtcccatcc agtcgccttt     4380

acagtgacta tcctgcccgt gaacgatcag ccacccattc tgacaactaa tacagggctg     4440

cagatgtggg aaggagccac tgtgcctatc ccagctgagg cactgagaag taccgacggg     4500

gattcaggac ctgaggacct ggtgtacaca attgaacagc caagcaatgg acgagtggtc     4560

ctgcgagcag ctccaggaac tgaggtgagg tctttcaccc aggcacagct ggatggggga     4620

ctggtgctgt ttagtcaccg aggcgctctg gacggcgggt tcaggttttc tctgagtgat     4680

ggcgagcaca cctcccctgg gcatttcttt agagtcacag cccagaagca ggtgctgctg     4740

tcactggaag ggagcaggac cctgacagtc tgcccaggat ctgtgcagcc cctgtctagt     4800

cagagtctgc gagcatcaag ctccgccgga accgaccctc accatctgct gtatagagtg     4860

gtcaggggac cacagctggg acggctgttc catgcacagc agggcagcac aggggaagcc     4920

ctggtgaact ttactcaggc tgaggtctac gcaggcaatg tgctgtatga gcacgaaatg     4980

cctccagaac ccttctggga ggcccatgac accctggagc tgcagctgtc tagtccccct     5040

gctcctgatg tggcagccac actggccgtg gctgtctcct ttgaggctgc atgtccacag     5100

cgcccctctc gactgtggaa gaacaaagga ctgtgggtgc cagaaggaca gcgagcagag     5160

atcaccgtgg ccgctctgga cgcctccaat ctgctggctt ctgtgcccag tcctcagcgg     5220

ccagagcacg atgtcctgtt ccaagtgact cagtttccca ccagaggaca gctgctggtg     5280

tcagaggaac cactgcacgc aggcaggcct catttcctgc agagcgagct ggcagcagga     5340

cagctggtgt acgcacacgg aggcggggga acccagcagg acggcttcag gtttcgcgca     5400

catctgcagg gacctgcagg agcatcagtg gctggaccac agactagcga agcttttgca     5460

atcaccgtgc gagatgtcaa cgagcggcca ccccagcctc aggcaagcgt gccactgcga     5520

ctgacaagag ggagcagggc acctatctcc agagcccagc tgtctgtggt cgaccccgat     5580

agcgcacctg gagagattga atatgaggtg cagagggccc cacacaacgg attcctgtcc     5640

ctggtcggcg ggggaccagg accagtgact cggttcaccc aggcagacgt ggatgctggc     5700

aggctggcat tcgtcgccaa tggctcaagc gtggctggga tctttcagct gtcaatgagc     5760

gacggggcat ctcctccact gcctatgagt ctggcagtgg atgtcctgcc atccgccatt     5820

gaggtccagc tgcgagctcc actggaagtg ccacaggcac tgggccggtc ctctctgtca     5880

cggcagcagc tgagagtggt cagcgaccgc gaggaacccg atgctgcata ccggctgatc     5940

cagggccctc agtatggaca cctgctggtg ggcgggcagc cagcatcagc tttcagccag     6000

ctgcaggtgg accagggaga ggtggtcttc gcctttacca acttcagttc aagccacgat     6060

catttttcag tcctggcact ggccagagga gtgaacgcta gcgcaacagt gaatgtcact     6120

gtgagggccc tgctgcacgt gtgggctgga ggcccttggc cacagggagc cacactgcga     6180

ctggacccta ctgtgctgga tgcaggagag ctggcaaatc gaaccggcag cgtgccacga     6240

ttccggctgc tggcaggacc tcgacatgga cgagtggtcc gggtgccaag agctaggact     6300

gagcccggcg gcagccagct ggtggaacag tttacccagc aggacctgga ggatgggcgg     6360

ctgggactgg aagtggggag gcctgaggga cgagctccag gacctgcagg ggacagtctg     6420

acactggagc tgtgggcaca gggagtgcct cccgcagtgg cttcactgga tttcgctact     6480

gaaccttaca acgccgctag accatatagt gtcgccctgc tgtcagtgcc agaagcagcc     6540

aggactgagg ctgggaaacc cgaatcctct actcctaccg gagagccagg ccccatggct     6600

agttcacctg tgccaaccgt cgcaaagggc gggttcctgg gatttctgga ggccaatatg     6660

ttcagcgtga tcattccagt gtgcctggtc ctgctgctgc tggccctgat cctgcccctg     6720

ctgttttacc tgcgcaagcg aaacaaagcc ggaaagcacg acgtgcaggt gctggctgca     6780

aaacctagaa atgggctggc cggagatgca gaggccttca ggaaggtgga accaggccag     6840

gctattcccc tggccgctgt gcctgggcag ggagcagccg ctggaggcca ggccgaccca     6900

gagctgctgc agttttgtag agcccctaat cccgccctga agaatggaca gtattgggtc     6960


<210>  2
<211>  2320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic consensus CSPG4

<400>  2

Gln Ser Gly Pro Arg Pro Pro Leu Pro Ala Pro Ala Leu Ala Leu Ala 
1               5                   10                  15      


Leu Thr Leu Ala Met Leu Ala Arg Ala Ser Ala Ala Ser Phe Phe Gly 
            20                  25                  30          


Glu Asn His Leu Glu Val Pro Val Ala Thr Ala Leu Thr Asp Ile Asp 
        35                  40                  45              


Leu Gln Leu Gln Phe Ser Thr Ser Gln Pro Glu Ala Leu Leu Leu Leu 
    50                  55                  60                  


Ala Ala Gly Pro Ala Asp His Leu Leu Leu Gln Leu Tyr Ser Gly Arg 
65                  70                  75                  80  


Leu Gln Val Arg Leu Val Leu Gly Gln Glu Glu Leu Arg Leu Gln Thr 
                85                  90                  95      


Pro Ala Glu Thr Leu Leu Ser Asp Ser Val Pro His Thr Val Val Leu 
            100                 105                 110         


Thr Val Ser Asp Ser Trp Ala Thr Leu Ser Val Asp Gly Leu Leu Asn 
        115                 120                 125             


Ala Ser Ala Pro Val Pro Gly Ala Pro Leu Glu Val Pro Tyr Gly Leu 
    130                 135                 140                 


Phe Val Gly Gly Thr Gly Ser Leu Gly Leu Pro Tyr Leu Arg Gly Thr 
145                 150                 155                 160 


Ser Arg Pro Leu Arg Gly Cys Leu His Ala Ala Thr Leu Asn Gly Arg 
                165                 170                 175     


Ser Leu Leu Arg Pro Leu Thr Pro Asp Val His Glu Gly Cys Ala Glu 
            180                 185                 190         


Glu Phe Ser Ala Gly Asp Asp Val Ala Leu Gly Phe Ser Gly Pro His 
        195                 200                 205             


Ser Leu Ala Ala Phe Pro Ala Trp Gly Thr Gln Asp Glu Gly Thr Leu 
    210                 215                 220                 


Glu Phe Thr Leu Thr Thr Arg Ser Arg Gln Ala Pro Leu Ala Phe Gln 
225                 230                 235                 240 


Ala Gly Gly Arg His Gly Asp Phe Ile Tyr Val Asp Ile Phe Glu Gly 
                245                 250                 255     


His Leu Arg Ala Val Val Glu Lys Gly Gln Gly Thr Val Leu Leu His 
            260                 265                 270         


Asn Ser Val Pro Val Ala Asp Gly Gln Pro His Glu Val Ser Val His 
        275                 280                 285             


Ile Asp Ala His Arg Leu Glu Ile Ser Val Asp Gln Tyr Pro Thr Arg 
    290                 295                 300                 


Thr Ser Asn Arg Gly Val Leu Ser Tyr Leu Glu Pro Arg Gly Ser Leu 
305                 310                 315                 320 


Leu Leu Gly Gly Leu Asp Ala Glu Ala Ser Arg His Leu Gln Glu His 
                325                 330                 335     


Arg Leu Gly Leu Ala Pro Glu Ala Thr Asn Ala Ser Leu Leu Gly Cys 
            340                 345                 350         


Met Glu Asp Leu Ser Val Asn Gly Gln Arg Arg Gly Leu Arg Glu Ala 
        355                 360                 365             


Leu Leu Thr Arg Asn Met Ala Ala Gly Cys Arg Leu Glu Glu Glu Glu 
    370                 375                 380                 


Tyr Glu Glu Asp Ala Tyr Gly Pro Tyr Glu Ala Phe Ser Thr Leu Ala 
385                 390                 395                 400 


Pro Glu Ala Trp Pro Ala Met Glu Leu Pro Glu Pro Cys Val Pro Glu 
                405                 410                 415     


Pro Gly Leu Pro Pro Val Phe Ala Asn Phe Thr Gln Leu Leu Thr Ile 
            420                 425                 430         


Ser Pro Leu Val Val Ala Glu Gly Gly Thr Ala Trp Leu Glu Trp Arg 
        435                 440                 445             


His Val Gln Pro Thr Leu Asp Leu Ser Glu Ala Glu Leu Arg Lys Ser 
    450                 455                 460                 


Gln Val Leu Phe Ser Val Thr Arg Gly Ala Arg His Gly Glu Leu Glu 
465                 470                 475                 480 


Leu Asp Ile Pro Gly Ala Gln Ala Arg Lys Met Phe Thr Leu Leu Asp 
                485                 490                 495     


Val Val Asn Arg Lys Ala Arg Phe Val His Asp Gly Ser Glu Asp Thr 
            500                 505                 510         


Ser Asp Gln Leu Val Leu Glu Val Ser Val Thr Ala Arg Gly Pro Met 
        515                 520                 525             


Pro Ser Cys Leu Arg Arg Gly Gln Thr Tyr Leu Leu Pro Ile Gln Val 
    530                 535                 540                 


Asn Pro Val Asn Asp Pro Pro Arg Ile Ile Phe Pro His Gly Ser Leu 
545                 550                 555                 560 


Met Val Ile Leu Glu His Thr Gln Lys Pro Leu Gly Pro Glu Val Phe 
                565                 570                 575     


Gln Ala Tyr Asp Pro Asp Ser Ala Cys Glu Gly Leu Thr Phe Gln Leu 
            580                 585                 590         


Leu Gly Thr Pro Ser Gly Leu Pro Val Glu Arg Arg Asp Gln Pro Gly 
        595                 600                 605             


Glu Pro Ala Thr Glu Phe Ser Cys Arg Glu Leu Glu Ala Gly Ser Leu 
    610                 615                 620                 


Val Tyr Val His Arg Gly Gly Pro Ala Gln Asp Leu Thr Phe Arg Val 
625                 630                 635                 640 


Ser Asp Gly Leu Gln Ala Ser Pro Pro Ala Thr Leu Lys Val Val Ala 
                645                 650                 655     


Val Arg Pro Ala Ile Gln Ile Arg His Ser Thr Gly Leu Arg Leu Ala 
            660                 665                 670         


Gln Gly Ser Ala Ala Pro Ile Leu Pro Ala Asn Leu Ser Val Glu Thr 
        675                 680                 685             


Asn Ala Val Gly Gln Asp Val Ser Val Leu Phe Arg Val Thr Gly Ala 
    690                 695                 700                 


Leu Gln Phe Gly Glu Leu Gln Lys Gln Gly Ala Gly Gly Val Glu Gly 
705                 710                 715                 720 


Ala Glu Trp Trp Ala Thr Gln Ala Phe His Gln Arg Asp Val Glu Gln 
                725                 730                 735     


Gly Arg Val Arg Tyr Leu Ser Thr Asp Pro Gln His Arg Ala Glu Asp 
            740                 745                 750         


Thr Val Glu Asn Leu Ala Leu Glu Val Gln Val Gly Gln Glu Thr Leu 
        755                 760                 765             


Ser Asn Leu Ser Phe Pro Val Thr Ile Gln Arg Ala Thr Val Trp Met 
    770                 775                 780                 


Leu Arg Leu Glu Pro Leu His Thr Gln Asn Thr Gln Gln Glu Ala Leu 
785                 790                 795                 800 


Thr Thr Ala His Leu Glu Ala Thr Leu Glu Glu Ala Gly Pro Ser Pro 
                805                 810                 815     


Pro Thr Phe His Tyr Glu Val Val Gln Ala Pro Arg Lys Gly Asn Leu 
            820                 825                 830         


Gln Leu Gln Gly Thr Arg Leu Ser Asp Gly Gln Gly Phe Thr Gln Asp 
        835                 840                 845             


Asp Leu Gln Ala Gly Arg Val Thr Tyr Gly Ala Thr Ala Arg Ala Ser 
    850                 855                 860                 


Glu Ala Val Glu Asp Thr Phe Arg Phe Arg Val Thr Ala Pro Pro His 
865                 870                 875                 880 


Phe Ser Pro Leu Tyr Thr Phe Pro Ile His Ile Gly Gly Asp Pro Asp 
                885                 890                 895     


Ala Pro Val Leu Thr Asn Val Leu Leu Ser Val Pro Glu Gly Gly Glu 
            900                 905                 910         


Gly Val Leu Ser Ala Asp His Leu Phe Val Lys Ser Leu Asn Ser Ala 
        915                 920                 925             


Ser Tyr Leu Tyr Glu Val Met Glu Arg Pro Arg His Gly Arg Leu Ala 
    930                 935                 940                 


Trp Arg Gly Thr Gln Asp Lys Thr Thr Met Val Thr Ser Phe Thr Asn 
945                 950                 955                 960 


Glu Asp Leu Leu Arg Gly Arg Leu Val Tyr Gln His Asp Asp Ser Glu 
                965                 970                 975     


Thr Thr Glu Asp Asp Ile Pro Phe Val Ala Thr Arg Gln Gly Glu Gly 
            980                 985                 990         


Ser Gly Asp Met Ala Trp Glu Glu  Val Arg Gly Val Phe  Arg Val Ala 
        995                 1000                 1005             


Ile Gln  Pro Val Asn Asp His  Ala Pro Val Gln Thr  Ile Ser Arg 
    1010                 1015                 1020             


Val Phe  His Val Ala Arg Gly  Gly Arg Arg Leu Leu  Thr Thr Asp 
    1025                 1030                 1035             


Asp Val  Ala Phe Ser Asp Ala  Asp Ser Gly Phe Ala  Asp Ala Gln 
    1040                 1045                 1050             


Leu Val  Leu Thr Arg Lys Asp  Leu Leu Phe Gly Ser  Ile Val Ala 
    1055                 1060                 1065             


Val Asp  Glu Pro Thr Arg Pro  Ile Tyr Arg Phe Thr  Gln Glu Asp 
    1070                 1075                 1080             


Leu Arg  Lys Arg Arg Val Leu  Phe Val His Ser Gly  Ala Asp Arg 
    1085                 1090                 1095             


Gly Trp  Ile Gln Leu Gln Val  Ser Asp Gly Gln His  Gln Ala Thr 
    1100                 1105                 1110             


Ala Leu  Leu Glu Val Gln Ala  Ser Glu Pro Tyr Leu  Arg Val Ala 
    1115                 1120                 1125             


Asn Gly  Ser Ser Leu Val Val  Pro Gln Gly Gly Gln  Gly Thr Ile 
    1130                 1135                 1140             


Asp Thr  Ala Val Leu His Leu  Asp Thr Asn Leu Asp  Ile Arg Ser 
    1145                 1150                 1155             


Gly Asp  Glu Val His Tyr His  Val Thr Ala Gly Pro  Arg Trp Gly 
    1160                 1165                 1170             


Gln Leu  Leu Arg Ala Gly Gln  Pro Ala Thr Ala Phe  Ser Gln Gln 
    1175                 1180                 1185             


Asp Leu  Leu Asp Gly Ala Ile  Leu Tyr Ser His Asn  Gly Ser Leu 
    1190                 1195                 1200             


Ser Pro  Arg Asp Thr Leu Ala  Phe Ser Val Glu Ala  Gly Pro Val 
    1205                 1210                 1215             


His Thr  Asp Ala Thr Leu Gln  Val Thr Ile Ala Leu  Glu Gly Pro 
    1220                 1225                 1230             


Leu Ala  Pro Leu His Leu Val  Gln His Lys Lys Ile  Tyr Val Phe 
    1235                 1240                 1245             


Gln Gly  Glu Ala Ala Glu Ile  Arg Arg Asp Gln Leu  Glu Ala Ala 
    1250                 1255                 1260             


Gln Glu  Ala Val Pro Pro Ala  Asp Ile Val Phe Ser  Val Lys Thr 
    1265                 1270                 1275             


Pro Pro  Ser Ala Gly Tyr Leu  Val Met Val Ser His  Gly Ala Leu 
    1280                 1285                 1290             


Ala Asp  Glu Pro Pro Ser Leu  Asp Pro Val Gln Ser  Phe Ser Gln 
    1295                 1300                 1305             


Glu Ala  Val Asp Ala Gly Arg  Val Leu Tyr Leu His  Ser Arg Pro 
    1310                 1315                 1320             


Glu Ala  Trp Ser Asp Ala Phe  Ser Leu Asp Val Ala  Ser Gly Leu 
    1325                 1330                 1335             


Gly Ala  Pro Leu Glu Gly Val  Leu Val Glu Leu Glu  Val Leu Pro 
    1340                 1345                 1350             


Ala Ala  Ile Pro Leu Glu Ala  Gln Asn Phe Ser Val  Pro Glu Gly 
    1355                 1360                 1365             


Gly Ser  Arg Thr Leu Ala Pro  Pro Leu Leu Arg Val  Thr Gly Pro 
    1370                 1375                 1380             


Tyr Phe  Pro Thr Leu Pro Gly  Leu Ser Leu Gln Val  Leu Glu Pro 
    1385                 1390                 1395             


Pro Gln  His Gly Ala Leu Gln  Arg Glu Glu Gly Pro  Gln Asp Arg 
    1400                 1405                 1410             


Thr Leu  Ser Ala Phe Ser Trp  Arg Glu Val Glu Glu  Gln Leu Ile 
    1415                 1420                 1425             


Arg Tyr  Val His Asp Gly Ser  Glu Thr Leu Thr Asp  Ser Phe Val 
    1430                 1435                 1440             


Leu Val  Ala Asn Ala Ser Glu  Met Asp Arg Gln Ser  His Pro Val 
    1445                 1450                 1455             


Ala Phe  Thr Val Thr Ile Leu  Pro Val Asn Asp Gln  Pro Pro Ile 
    1460                 1465                 1470             


Leu Thr  Thr Asn Thr Gly Leu  Gln Met Trp Glu Gly  Ala Thr Val 
    1475                 1480                 1485             


Pro Ile  Pro Ala Glu Ala Leu  Arg Ser Thr Asp Gly  Asp Ser Gly 
    1490                 1495                 1500             


Pro Glu  Asp Leu Val Tyr Thr  Ile Glu Gln Pro Ser  Asn Gly Arg 
    1505                 1510                 1515             


Val Val  Leu Arg Ala Ala Pro  Gly Thr Glu Val Arg  Ser Phe Thr 
    1520                 1525                 1530             


Gln Ala  Gln Leu Asp Gly Gly  Leu Val Leu Phe Ser  His Arg Gly 
    1535                 1540                 1545             


Ala Leu  Asp Gly Gly Phe Arg  Phe Ser Leu Ser Asp  Gly Glu His 
    1550                 1555                 1560             


Thr Ser  Pro Gly His Phe Phe  Arg Val Thr Ala Gln  Lys Gln Val 
    1565                 1570                 1575             


Leu Leu  Ser Leu Glu Gly Ser  Arg Thr Leu Thr Val  Cys Pro Gly 
    1580                 1585                 1590             


Ser Val  Gln Pro Leu Ser Ser  Gln Ser Leu Arg Ala  Ser Ser Ser 
    1595                 1600                 1605             


Ala Gly  Thr Asp Pro His His  Leu Leu Tyr Arg Val  Val Arg Gly 
    1610                 1615                 1620             


Pro Gln  Leu Gly Arg Leu Phe  His Ala Gln Gln Gly  Ser Thr Gly 
    1625                 1630                 1635             


Glu Ala  Leu Val Asn Phe Thr  Gln Ala Glu Val Tyr  Ala Gly Asn 
    1640                 1645                 1650             


Val Leu  Tyr Glu His Glu Met  Pro Pro Glu Pro Phe  Trp Glu Ala 
    1655                 1660                 1665             


His Asp  Thr Leu Glu Leu Gln  Leu Ser Ser Pro Pro  Ala Pro Asp 
    1670                 1675                 1680             


Val Ala  Ala Thr Leu Ala Val  Ala Val Ser Phe Glu  Ala Ala Cys 
    1685                 1690                 1695             


Pro Gln  Arg Pro Ser Arg Leu  Trp Lys Asn Lys Gly  Leu Trp Val 
    1700                 1705                 1710             


Pro Glu  Gly Gln Arg Ala Glu  Ile Thr Val Ala Ala  Leu Asp Ala 
    1715                 1720                 1725             


Ser Asn  Leu Leu Ala Ser Val  Pro Ser Pro Gln Arg  Pro Glu His 
    1730                 1735                 1740             


Asp Val  Leu Phe Gln Val Thr  Gln Phe Pro Thr Arg  Gly Gln Leu 
    1745                 1750                 1755             


Leu Val  Ser Glu Glu Pro Leu  His Ala Gly Arg Pro  His Phe Leu 
    1760                 1765                 1770             


Gln Ser  Glu Leu Ala Ala Gly  Gln Leu Val Tyr Ala  His Gly Gly 
    1775                 1780                 1785             


Gly Gly  Thr Gln Gln Asp Gly  Phe Arg Phe Arg Ala  His Leu Gln 
    1790                 1795                 1800             


Gly Pro  Ala Gly Ala Ser Val  Ala Gly Pro Gln Thr  Ser Glu Ala 
    1805                 1810                 1815             


Phe Ala  Ile Thr Val Arg Asp  Val Asn Glu Arg Pro  Pro Gln Pro 
    1820                 1825                 1830             


Gln Ala  Ser Val Pro Leu Arg  Leu Thr Arg Gly Ser  Arg Ala Pro 
    1835                 1840                 1845             


Ile Ser  Arg Ala Gln Leu Ser  Val Val Asp Pro Asp  Ser Ala Pro 
    1850                 1855                 1860             


Gly Glu  Ile Glu Tyr Glu Val  Gln Arg Ala Pro His  Asn Gly Phe 
    1865                 1870                 1875             


Leu Ser  Leu Val Gly Gly Gly  Pro Gly Pro Val Thr  Arg Phe Thr 
    1880                 1885                 1890             


Gln Ala  Asp Val Asp Ala Gly  Arg Leu Ala Phe Val  Ala Asn Gly 
    1895                 1900                 1905             


Ser Ser  Val Ala Gly Ile Phe  Gln Leu Ser Met Ser  Asp Gly Ala 
    1910                 1915                 1920             


Ser Pro  Pro Leu Pro Met Ser  Leu Ala Val Asp Val  Leu Pro Ser 
    1925                 1930                 1935             


Ala Ile  Glu Val Gln Leu Arg  Ala Pro Leu Glu Val  Pro Gln Ala 
    1940                 1945                 1950             


Leu Gly  Arg Ser Ser Leu Ser  Arg Gln Gln Leu Arg  Val Val Ser 
    1955                 1960                 1965             


Asp Arg  Glu Glu Pro Asp Ala  Ala Tyr Arg Leu Ile  Gln Gly Pro 
    1970                 1975                 1980             


Gln Tyr  Gly His Leu Leu Val  Gly Gly Gln Pro Ala  Ser Ala Phe 
    1985                 1990                 1995             


Ser Gln  Leu Gln Val Asp Gln  Gly Glu Val Val Phe  Ala Phe Thr 
    2000                 2005                 2010             


Asn Phe  Ser Ser Ser His Asp  His Phe Ser Val Leu  Ala Leu Ala 
    2015                 2020                 2025             


Arg Gly  Val Asn Ala Ser Ala  Thr Val Asn Val Thr  Val Arg Ala 
    2030                 2035                 2040             


Leu Leu  His Val Trp Ala Gly  Gly Pro Trp Pro Gln  Gly Ala Thr 
    2045                 2050                 2055             


Leu Arg  Leu Asp Pro Thr Val  Leu Asp Ala Gly Glu  Leu Ala Asn 
    2060                 2065                 2070             


Arg Thr  Gly Ser Val Pro Arg  Phe Arg Leu Leu Ala  Gly Pro Arg 
    2075                 2080                 2085             


His Gly  Arg Val Val Arg Val  Pro Arg Ala Arg Thr  Glu Pro Gly 
    2090                 2095                 2100             


Gly Ser  Gln Leu Val Glu Gln  Phe Thr Gln Gln Asp  Leu Glu Asp 
    2105                 2110                 2115             


Gly Arg  Leu Gly Leu Glu Val  Gly Arg Pro Glu Gly  Arg Ala Pro 
    2120                 2125                 2130             


Gly Pro  Ala Gly Asp Ser Leu  Thr Leu Glu Leu Trp  Ala Gln Gly 
    2135                 2140                 2145             


Val Pro  Pro Ala Val Ala Ser  Leu Asp Phe Ala Thr  Glu Pro Tyr 
    2150                 2155                 2160             


Asn Ala  Ala Arg Pro Tyr Ser  Val Ala Leu Leu Ser  Val Pro Glu 
    2165                 2170                 2175             


Ala Ala  Arg Thr Glu Ala Gly  Lys Pro Glu Ser Ser  Thr Pro Thr 
    2180                 2185                 2190             


Gly Glu  Pro Gly Pro Met Ala  Ser Ser Pro Val Pro  Thr Val Ala 
    2195                 2200                 2205             


Lys Gly  Gly Phe Leu Gly Phe  Leu Glu Ala Asn Met  Phe Ser Val 
    2210                 2215                 2220             


Ile Ile  Pro Val Cys Leu Val  Leu Leu Leu Leu Ala  Leu Ile Leu 
    2225                 2230                 2235             


Pro Leu  Leu Phe Tyr Leu Arg  Lys Arg Asn Lys Ala  Gly Lys His 
    2240                 2245                 2250             


Asp Val  Gln Val Leu Ala Ala  Lys Pro Arg Asn Gly  Leu Ala Gly 
    2255                 2260                 2265             


Asp Ala  Glu Ala Phe Arg Lys  Val Glu Pro Gly Gln  Ala Ile Pro 
    2270                 2275                 2280             


Leu Ala  Ala Val Pro Gly Gln  Gly Ala Ala Ala Gly  Gly Gln Ala 
    2285                 2290                 2295             


Asp Pro  Glu Leu Leu Gln Phe  Cys Arg Ala Pro Asn  Pro Ala Leu 
    2300                 2305                 2310             


Lys Asn  Gly Gln Tyr Trp Val  
    2315                 2320 


<210>  3
<211>  7020
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic consensus CSPG4 operably linked to IgE leader sequence

<400>  3
atggattgga cctggattct gtttctggtg gccgccgcta caagagtgca ttcacagtct       60

ggacctcgac cccctctgcc cgcccctgca ctggccctgg ctctgaccct ggcaatgctg      120

gcaagagcct ccgccgcttc tttctttggc gaaaaccacc tggaggtgcc cgtcgctaca      180

gcactgactg acatcgatct gcagctgcag ttcagcacat cccagccaga ggccctgctg      240

ctgctggcag caggccctgc tgaccatctg ctgctgcagc tgtacagcgg aagactgcag      300

gtcaggctgg tgctgggaca ggaggaactg cgactgcaga caccagccga gactctgctg      360

tctgatagtg tcccccacac cgtggtcctg acagtgtcag acagctgggc caccctgtcc      420

gtcgatggac tgctgaacgc atctgctcca gtgccaggag cccctctgga ggtcccatac      480

ggactgttcg tgggcgggac aggctctctg ggactgccat atctgcgggg gactagtcgg      540

cccctgagag gatgcctgca cgctgcaacc ctgaatggcc gctccctgct gcgaccactg      600

acacctgacg tgcatgaggg ctgtgccgag gaattttctg ctggggacga tgtggcactg      660

ggattctccg gaccacactc tctggcagct tttcctgcct ggggcaccca ggatgaaggg      720

actctggagt tcaccctgac cacaaggtcc cgccaggctc ccctggcatt tcaggccgga      780

ggccgccacg gcgacttcat ctacgtggat atttttgagg ggcatctgcg ggccgtggtc      840

gaaaaggggc agggaacagt gctgctgcac aactctgtgc cagtcgcaga cggccagccc      900

catgaagtga gtgtccacat cgacgctcat agactggaga tttcagtgga tcagtaccct      960

acccggacaa gcaatagagg ggtgctgtcc tatctggagc caaggggaag cctgctgctg     1020

ggcggcctgg acgcagaggc ctccagacac ctgcaggaac ataggctggg cctggctccc     1080

gaagcaacaa acgcctccct gctggggtgc atggaggatc tgtctgtgaa tggacagcga     1140

agaggactgc gagaggccct gctgactcga aacatggcag ccggatgtcg gctggaggaa     1200

gaggaatatg aggaagacgc ttacggccct tatgaggcat tcagcaccct ggctcccgaa     1260

gcatggcctg ccatggaact gcctgagcca tgcgtcccag agcctggact gcctcccgtg     1320

ttcgccaact tcacccagct gctgactatc tctccactgg tggtcgcaga gggcgggact     1380

gcttggctgg aatggcgaca cgtgcagccc accctggacc tgagcgaggc cgaactgcgg     1440

aaatcccagg tgctgttttc tgtcaccagg ggagctcgcc atggcgagct ggaactggat     1500

attcccggag ctcaggcaag aaaaatgttc acactgctgg acgtggtcaa ccgaaaggcc     1560

cggtttgtgc acgatggcag tgaagacaca tcagatcagc tggtgctgga ggtgagtgtc     1620

actgccagag gcccaatgcc ctcatgtctg aggcgcgggc agacctacct gctgcctatc     1680

caggtcaacc cagtgaatga cccacccagg atcattttcc cacacgggtc cctgatggtc     1740

atcctggagc atacacagaa gccactggga cccgaggtgt tccaggccta tgaccccgat     1800

agcgcctgcg agggcctgac ttttcagctg ctgggaaccc catccggact gccagtggaa     1860

cgacgagatc agcctggcga accagcaacc gagttcagtt gtcgcgagct ggaagccggg     1920

tcactggtgt acgtccacag aggaggccca gcacaggacc tgaccttccg ggtgagcgat     1980

ggcctgcagg ctagtcctcc agcaactctg aaagtggtcg ccgtgcggcc tgctatccag     2040

attagacata gcaccggact gaggctggca cagggctccg ctgcacccat cctgcctgcc     2100

aacctgtctg tcgagaccaa tgctgtgggc caggacgtga gtgtcctgtt cagggtgaca     2160

ggagccctgc agtttggaga gctgcagaag cagggagcag ggggagtgga aggagcagag     2220

tggtgggcta cccaggcatt ccaccagcga gatgtcgagc agggacgagt gcggtacctg     2280

agcaccgacc cccagcatcg ggcagaagat acagtggaga acctggccct ggaggtgcag     2340

gtcggacagg aaacactgag taatctgtca tttcccgtca ccattcagag ggccacagtg     2400

tggatgctgc gcctggagcc tctgcacacc cagaacacac agcaggaggc actgactacc     2460

gcccatctgg aagctactct ggaggaagca ggacctagcc ctcccacctt ccactatgag     2520

gtggtccagg ctccacgcaa gggcaatctg cagctgcagg gaactagact gtctgacgga     2580

caggggttta cccaggacga tctgcaggca ggacgagtga cctacggagc aacagccaga     2640

gccagtgaag ccgtcgagga taccttccgg ttccgggtga ctgctccacc ccacttctct     2700

cccctgtata cttttcctat ccatattggc ggggacccag atgcacccgt gctgaccaac     2760

gtcctgctgt ccgtgccaga aggaggcgag ggcgtcctga gcgcagacca cctgttcgtg     2820

aaatccctga attccgcctc ttacctgtat gaagtgatgg agcgaccacg acatggaagg     2880

ctggcatggc gaggaaccca ggacaagaca actatggtga ctagcttcac caacgaggat     2940

ctgctgcggg gcagactggt gtaccagcac gacgattccg aaaccacaga ggacgatatc     3000

ccctttgtgg ctactagaca gggagagggc tctggggaca tggcatggga ggaagtccga     3060

ggcgtgttcc gggtcgctat ccagcctgtc aatgatcacg caccagtgca gacaattagc     3120

cgcgtgtttc atgtcgcccg agggggaaga aggctgctga ctaccgacga tgtggcattc     3180

agcgacgccg attccggatt tgccgacgct cagctggtgc tgaccaggaa agatctgctg     3240

ttcggctcca tcgtggccgt cgacgaacct accagaccaa tctacaggtt cacacaggag     3300

gatctgcgca agcgccgagt gctgtttgtc cactccggag cagaccgagg atggattcag     3360

ctgcaggtgt ctgatggcca gcatcaggca accgccctgc tggaagtcca ggcctctgag     3420

ccctatctgc gcgtggctaa cgggagctcc ctggtggtcc ctcagggcgg gcagggaaca     3480

atcgacactg ccgtgctgca cctggacaca aatctggata ttcggagcgg agatgaggtc     3540

cactaccatg tgactgctgg accacgatgg ggacagctgc tgagagcagg acagccagct     3600

accgcattca gtcagcagga cctgctggat ggagccatcc tgtattcaca caacggcagt     3660

ctgtcaccca gggacactct ggccttcagc gtcgaggcag gacctgtgca taccgatgcc     3720

acactgcagg tgaccattgc tctggaagga cccctggcac ctctgcacct ggtccagcat     3780

aagaaaatct acgtgttcca gggcgaagcc gctgagattc ggagagacca gctggaagca     3840

gcccaggagg ctgtgcctcc agcagatatc gtgttttcag tcaaaacccc tcccagcgcc     3900

ggatacctgg tcatggtgag ccacggagcc ctggctgacg aaccacccag cctggacccc     3960

gtgcagagct tctcccagga ggcagtcgac gctggacgag tgctgtatct gcattcccgg     4020

cctgaggcct ggtctgacgc ttttagtctg gatgtggctt ctggactggg cgcaccactg     4080

gaaggggtgc tggtcgagct ggaagtgctg cctgctgcaa tcccactgga ggcccagaat     4140

ttctccgtcc ctgaaggagg ctctcggacc ctggctcctc cactgctgag agtgaccggc     4200

ccatactttc ccacactgcc tggactgtcc ctgcaggtgc tggagccccc tcagcacggc     4260

gccctgcaga gagaggaagg accccaggac aggacactga gcgccttcag ctggagagaa     4320

gtcgaggaac agctgattcg ctatgtgcac gacggcagtg agactctgac cgattcattc     4380

gtgctggtcg caaacgccag cgaaatggac cggcagtccc atccagtcgc ctttacagtg     4440

actatcctgc ccgtgaacga tcagccaccc attctgacaa ctaatacagg gctgcagatg     4500

tgggaaggag ccactgtgcc tatcccagct gaggcactga gaagtaccga cggggattca     4560

ggacctgagg acctggtgta cacaattgaa cagccaagca atggacgagt ggtcctgcga     4620

gcagctccag gaactgaggt gaggtctttc acccaggcac agctggatgg gggactggtg     4680

ctgtttagtc accgaggcgc tctggacggc gggttcaggt tttctctgag tgatggcgag     4740

cacacctccc ctgggcattt ctttagagtc acagcccaga agcaggtgct gctgtcactg     4800

gaagggagca ggaccctgac agtctgccca ggatctgtgc agcccctgtc tagtcagagt     4860

ctgcgagcat caagctccgc cggaaccgac cctcaccatc tgctgtatag agtggtcagg     4920

ggaccacagc tgggacggct gttccatgca cagcagggca gcacagggga agccctggtg     4980

aactttactc aggctgaggt ctacgcaggc aatgtgctgt atgagcacga aatgcctcca     5040

gaacccttct gggaggccca tgacaccctg gagctgcagc tgtctagtcc ccctgctcct     5100

gatgtggcag ccacactggc cgtggctgtc tcctttgagg ctgcatgtcc acagcgcccc     5160

tctcgactgt ggaagaacaa aggactgtgg gtgccagaag gacagcgagc agagatcacc     5220

gtggccgctc tggacgcctc caatctgctg gcttctgtgc ccagtcctca gcggccagag     5280

cacgatgtcc tgttccaagt gactcagttt cccaccagag gacagctgct ggtgtcagag     5340

gaaccactgc acgcaggcag gcctcatttc ctgcagagcg agctggcagc aggacagctg     5400

gtgtacgcac acggaggcgg gggaacccag caggacggct tcaggtttcg cgcacatctg     5460

cagggacctg caggagcatc agtggctgga ccacagacta gcgaagcttt tgcaatcacc     5520

gtgcgagatg tcaacgagcg gccaccccag cctcaggcaa gcgtgccact gcgactgaca     5580

agagggagca gggcacctat ctccagagcc cagctgtctg tggtcgaccc cgatagcgca     5640

cctggagaga ttgaatatga ggtgcagagg gccccacaca acggattcct gtccctggtc     5700

ggcgggggac caggaccagt gactcggttc acccaggcag acgtggatgc tggcaggctg     5760

gcattcgtcg ccaatggctc aagcgtggct gggatctttc agctgtcaat gagcgacggg     5820

gcatctcctc cactgcctat gagtctggca gtggatgtcc tgccatccgc cattgaggtc     5880

cagctgcgag ctccactgga agtgccacag gcactgggcc ggtcctctct gtcacggcag     5940

cagctgagag tggtcagcga ccgcgaggaa cccgatgctg cataccggct gatccagggc     6000

cctcagtatg gacacctgct ggtgggcggg cagccagcat cagctttcag ccagctgcag     6060

gtggaccagg gagaggtggt cttcgccttt accaacttca gttcaagcca cgatcatttt     6120

tcagtcctgg cactggccag aggagtgaac gctagcgcaa cagtgaatgt cactgtgagg     6180

gccctgctgc acgtgtgggc tggaggccct tggccacagg gagccacact gcgactggac     6240

cctactgtgc tggatgcagg agagctggca aatcgaaccg gcagcgtgcc acgattccgg     6300

ctgctggcag gacctcgaca tggacgagtg gtccgggtgc caagagctag gactgagccc     6360

ggcggcagcc agctggtgga acagtttacc cagcaggacc tggaggatgg gcggctggga     6420

ctggaagtgg ggaggcctga gggacgagct ccaggacctg caggggacag tctgacactg     6480

gagctgtggg cacagggagt gcctcccgca gtggcttcac tggatttcgc tactgaacct     6540

tacaacgccg ctagaccata tagtgtcgcc ctgctgtcag tgccagaagc agccaggact     6600

gaggctggga aacccgaatc ctctactcct accggagagc caggccccat ggctagttca     6660

cctgtgccaa ccgtcgcaaa gggcgggttc ctgggatttc tggaggccaa tatgttcagc     6720

gtgatcattc cagtgtgcct ggtcctgctg ctgctggccc tgatcctgcc cctgctgttt     6780

tacctgcgca agcgaaacaa agccggaaag cacgacgtgc aggtgctggc tgcaaaacct     6840

agaaatgggc tggccggaga tgcagaggcc ttcaggaagg tggaaccagg ccaggctatt     6900

cccctggccg ctgtgcctgg gcagggagca gccgctggag gccaggccga cccagagctg     6960

ctgcagtttt gtagagcccc taatcccgcc ctgaagaatg gacagtattg ggtctgataa     7020


<210>  4
<211>  2338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic consensus CSPG4 operably linked to IgE leader sequence

<400>  4

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Gln Ser Gly Pro Arg Pro Pro Leu Pro Ala Pro Ala Leu Ala 
            20                  25                  30          


Leu Ala Leu Thr Leu Ala Met Leu Ala Arg Ala Ser Ala Ala Ser Phe 
        35                  40                  45              


Phe Gly Glu Asn His Leu Glu Val Pro Val Ala Thr Ala Leu Thr Asp 
    50                  55                  60                  


Ile Asp Leu Gln Leu Gln Phe Ser Thr Ser Gln Pro Glu Ala Leu Leu 
65                  70                  75                  80  


Leu Leu Ala Ala Gly Pro Ala Asp His Leu Leu Leu Gln Leu Tyr Ser 
                85                  90                  95      


Gly Arg Leu Gln Val Arg Leu Val Leu Gly Gln Glu Glu Leu Arg Leu 
            100                 105                 110         


Gln Thr Pro Ala Glu Thr Leu Leu Ser Asp Ser Val Pro His Thr Val 
        115                 120                 125             


Val Leu Thr Val Ser Asp Ser Trp Ala Thr Leu Ser Val Asp Gly Leu 
    130                 135                 140                 


Leu Asn Ala Ser Ala Pro Val Pro Gly Ala Pro Leu Glu Val Pro Tyr 
145                 150                 155                 160 


Gly Leu Phe Val Gly Gly Thr Gly Ser Leu Gly Leu Pro Tyr Leu Arg 
                165                 170                 175     


Gly Thr Ser Arg Pro Leu Arg Gly Cys Leu His Ala Ala Thr Leu Asn 
            180                 185                 190         


Gly Arg Ser Leu Leu Arg Pro Leu Thr Pro Asp Val His Glu Gly Cys 
        195                 200                 205             


Ala Glu Glu Phe Ser Ala Gly Asp Asp Val Ala Leu Gly Phe Ser Gly 
    210                 215                 220                 


Pro His Ser Leu Ala Ala Phe Pro Ala Trp Gly Thr Gln Asp Glu Gly 
225                 230                 235                 240 


Thr Leu Glu Phe Thr Leu Thr Thr Arg Ser Arg Gln Ala Pro Leu Ala 
                245                 250                 255     


Phe Gln Ala Gly Gly Arg His Gly Asp Phe Ile Tyr Val Asp Ile Phe 
            260                 265                 270         


Glu Gly His Leu Arg Ala Val Val Glu Lys Gly Gln Gly Thr Val Leu 
        275                 280                 285             


Leu His Asn Ser Val Pro Val Ala Asp Gly Gln Pro His Glu Val Ser 
    290                 295                 300                 


Val His Ile Asp Ala His Arg Leu Glu Ile Ser Val Asp Gln Tyr Pro 
305                 310                 315                 320 


Thr Arg Thr Ser Asn Arg Gly Val Leu Ser Tyr Leu Glu Pro Arg Gly 
                325                 330                 335     


Ser Leu Leu Leu Gly Gly Leu Asp Ala Glu Ala Ser Arg His Leu Gln 
            340                 345                 350         


Glu His Arg Leu Gly Leu Ala Pro Glu Ala Thr Asn Ala Ser Leu Leu 
        355                 360                 365             


Gly Cys Met Glu Asp Leu Ser Val Asn Gly Gln Arg Arg Gly Leu Arg 
    370                 375                 380                 


Glu Ala Leu Leu Thr Arg Asn Met Ala Ala Gly Cys Arg Leu Glu Glu 
385                 390                 395                 400 


Glu Glu Tyr Glu Glu Asp Ala Tyr Gly Pro Tyr Glu Ala Phe Ser Thr 
                405                 410                 415     


Leu Ala Pro Glu Ala Trp Pro Ala Met Glu Leu Pro Glu Pro Cys Val 
            420                 425                 430         


Pro Glu Pro Gly Leu Pro Pro Val Phe Ala Asn Phe Thr Gln Leu Leu 
        435                 440                 445             


Thr Ile Ser Pro Leu Val Val Ala Glu Gly Gly Thr Ala Trp Leu Glu 
    450                 455                 460                 


Trp Arg His Val Gln Pro Thr Leu Asp Leu Ser Glu Ala Glu Leu Arg 
465                 470                 475                 480 


Lys Ser Gln Val Leu Phe Ser Val Thr Arg Gly Ala Arg His Gly Glu 
                485                 490                 495     


Leu Glu Leu Asp Ile Pro Gly Ala Gln Ala Arg Lys Met Phe Thr Leu 
            500                 505                 510         


Leu Asp Val Val Asn Arg Lys Ala Arg Phe Val His Asp Gly Ser Glu 
        515                 520                 525             


Asp Thr Ser Asp Gln Leu Val Leu Glu Val Ser Val Thr Ala Arg Gly 
    530                 535                 540                 


Pro Met Pro Ser Cys Leu Arg Arg Gly Gln Thr Tyr Leu Leu Pro Ile 
545                 550                 555                 560 


Gln Val Asn Pro Val Asn Asp Pro Pro Arg Ile Ile Phe Pro His Gly 
                565                 570                 575     


Ser Leu Met Val Ile Leu Glu His Thr Gln Lys Pro Leu Gly Pro Glu 
            580                 585                 590         


Val Phe Gln Ala Tyr Asp Pro Asp Ser Ala Cys Glu Gly Leu Thr Phe 
        595                 600                 605             


Gln Leu Leu Gly Thr Pro Ser Gly Leu Pro Val Glu Arg Arg Asp Gln 
    610                 615                 620                 


Pro Gly Glu Pro Ala Thr Glu Phe Ser Cys Arg Glu Leu Glu Ala Gly 
625                 630                 635                 640 


Ser Leu Val Tyr Val His Arg Gly Gly Pro Ala Gln Asp Leu Thr Phe 
                645                 650                 655     


Arg Val Ser Asp Gly Leu Gln Ala Ser Pro Pro Ala Thr Leu Lys Val 
            660                 665                 670         


Val Ala Val Arg Pro Ala Ile Gln Ile Arg His Ser Thr Gly Leu Arg 
        675                 680                 685             


Leu Ala Gln Gly Ser Ala Ala Pro Ile Leu Pro Ala Asn Leu Ser Val 
    690                 695                 700                 


Glu Thr Asn Ala Val Gly Gln Asp Val Ser Val Leu Phe Arg Val Thr 
705                 710                 715                 720 


Gly Ala Leu Gln Phe Gly Glu Leu Gln Lys Gln Gly Ala Gly Gly Val 
                725                 730                 735     


Glu Gly Ala Glu Trp Trp Ala Thr Gln Ala Phe His Gln Arg Asp Val 
            740                 745                 750         


Glu Gln Gly Arg Val Arg Tyr Leu Ser Thr Asp Pro Gln His Arg Ala 
        755                 760                 765             


Glu Asp Thr Val Glu Asn Leu Ala Leu Glu Val Gln Val Gly Gln Glu 
    770                 775                 780                 


Thr Leu Ser Asn Leu Ser Phe Pro Val Thr Ile Gln Arg Ala Thr Val 
785                 790                 795                 800 


Trp Met Leu Arg Leu Glu Pro Leu His Thr Gln Asn Thr Gln Gln Glu 
                805                 810                 815     


Ala Leu Thr Thr Ala His Leu Glu Ala Thr Leu Glu Glu Ala Gly Pro 
            820                 825                 830         


Ser Pro Pro Thr Phe His Tyr Glu Val Val Gln Ala Pro Arg Lys Gly 
        835                 840                 845             


Asn Leu Gln Leu Gln Gly Thr Arg Leu Ser Asp Gly Gln Gly Phe Thr 
    850                 855                 860                 


Gln Asp Asp Leu Gln Ala Gly Arg Val Thr Tyr Gly Ala Thr Ala Arg 
865                 870                 875                 880 


Ala Ser Glu Ala Val Glu Asp Thr Phe Arg Phe Arg Val Thr Ala Pro 
                885                 890                 895     


Pro His Phe Ser Pro Leu Tyr Thr Phe Pro Ile His Ile Gly Gly Asp 
            900                 905                 910         


Pro Asp Ala Pro Val Leu Thr Asn Val Leu Leu Ser Val Pro Glu Gly 
        915                 920                 925             


Gly Glu Gly Val Leu Ser Ala Asp His Leu Phe Val Lys Ser Leu Asn 
    930                 935                 940                 


Ser Ala Ser Tyr Leu Tyr Glu Val Met Glu Arg Pro Arg His Gly Arg 
945                 950                 955                 960 


Leu Ala Trp Arg Gly Thr Gln Asp Lys Thr Thr Met Val Thr Ser Phe 
                965                 970                 975     


Thr Asn Glu Asp Leu Leu Arg Gly Arg Leu Val Tyr Gln His Asp Asp 
            980                 985                 990         


Ser Glu Thr Thr Glu Asp Asp Ile  Pro Phe Val Ala Thr  Arg Gln Gly 
        995                 1000                 1005             


Glu Gly  Ser Gly Asp Met Ala  Trp Glu Glu Val Arg  Gly Val Phe 
    1010                 1015                 1020             


Arg Val  Ala Ile Gln Pro Val  Asn Asp His Ala Pro  Val Gln Thr 
    1025                 1030                 1035             


Ile Ser  Arg Val Phe His Val  Ala Arg Gly Gly Arg  Arg Leu Leu 
    1040                 1045                 1050             


Thr Thr  Asp Asp Val Ala Phe  Ser Asp Ala Asp Ser  Gly Phe Ala 
    1055                 1060                 1065             


Asp Ala  Gln Leu Val Leu Thr  Arg Lys Asp Leu Leu  Phe Gly Ser 
    1070                 1075                 1080             


Ile Val  Ala Val Asp Glu Pro  Thr Arg Pro Ile Tyr  Arg Phe Thr 
    1085                 1090                 1095             


Gln Glu  Asp Leu Arg Lys Arg  Arg Val Leu Phe Val  His Ser Gly 
    1100                 1105                 1110             


Ala Asp  Arg Gly Trp Ile Gln  Leu Gln Val Ser Asp  Gly Gln His 
    1115                 1120                 1125             


Gln Ala  Thr Ala Leu Leu Glu  Val Gln Ala Ser Glu  Pro Tyr Leu 
    1130                 1135                 1140             


Arg Val  Ala Asn Gly Ser Ser  Leu Val Val Pro Gln  Gly Gly Gln 
    1145                 1150                 1155             


Gly Thr  Ile Asp Thr Ala Val  Leu His Leu Asp Thr  Asn Leu Asp 
    1160                 1165                 1170             


Ile Arg  Ser Gly Asp Glu Val  His Tyr His Val Thr  Ala Gly Pro 
    1175                 1180                 1185             


Arg Trp  Gly Gln Leu Leu Arg  Ala Gly Gln Pro Ala  Thr Ala Phe 
    1190                 1195                 1200             


Ser Gln  Gln Asp Leu Leu Asp  Gly Ala Ile Leu Tyr  Ser His Asn 
    1205                 1210                 1215             


Gly Ser  Leu Ser Pro Arg Asp  Thr Leu Ala Phe Ser  Val Glu Ala 
    1220                 1225                 1230             


Gly Pro  Val His Thr Asp Ala  Thr Leu Gln Val Thr  Ile Ala Leu 
    1235                 1240                 1245             


Glu Gly  Pro Leu Ala Pro Leu  His Leu Val Gln His  Lys Lys Ile 
    1250                 1255                 1260             


Tyr Val  Phe Gln Gly Glu Ala  Ala Glu Ile Arg Arg  Asp Gln Leu 
    1265                 1270                 1275             


Glu Ala  Ala Gln Glu Ala Val  Pro Pro Ala Asp Ile  Val Phe Ser 
    1280                 1285                 1290             


Val Lys  Thr Pro Pro Ser Ala  Gly Tyr Leu Val Met  Val Ser His 
    1295                 1300                 1305             


Gly Ala  Leu Ala Asp Glu Pro  Pro Ser Leu Asp Pro  Val Gln Ser 
    1310                 1315                 1320             


Phe Ser  Gln Glu Ala Val Asp  Ala Gly Arg Val Leu  Tyr Leu His 
    1325                 1330                 1335             


Ser Arg  Pro Glu Ala Trp Ser  Asp Ala Phe Ser Leu  Asp Val Ala 
    1340                 1345                 1350             


Ser Gly  Leu Gly Ala Pro Leu  Glu Gly Val Leu Val  Glu Leu Glu 
    1355                 1360                 1365             


Val Leu  Pro Ala Ala Ile Pro  Leu Glu Ala Gln Asn  Phe Ser Val 
    1370                 1375                 1380             


Pro Glu  Gly Gly Ser Arg Thr  Leu Ala Pro Pro Leu  Leu Arg Val 
    1385                 1390                 1395             


Thr Gly  Pro Tyr Phe Pro Thr  Leu Pro Gly Leu Ser  Leu Gln Val 
    1400                 1405                 1410             


Leu Glu  Pro Pro Gln His Gly  Ala Leu Gln Arg Glu  Glu Gly Pro 
    1415                 1420                 1425             


Gln Asp  Arg Thr Leu Ser Ala  Phe Ser Trp Arg Glu  Val Glu Glu 
    1430                 1435                 1440             


Gln Leu  Ile Arg Tyr Val His  Asp Gly Ser Glu Thr  Leu Thr Asp 
    1445                 1450                 1455             


Ser Phe  Val Leu Val Ala Asn  Ala Ser Glu Met Asp  Arg Gln Ser 
    1460                 1465                 1470             


His Pro  Val Ala Phe Thr Val  Thr Ile Leu Pro Val  Asn Asp Gln 
    1475                 1480                 1485             


Pro Pro  Ile Leu Thr Thr Asn  Thr Gly Leu Gln Met  Trp Glu Gly 
    1490                 1495                 1500             


Ala Thr  Val Pro Ile Pro Ala  Glu Ala Leu Arg Ser  Thr Asp Gly 
    1505                 1510                 1515             


Asp Ser  Gly Pro Glu Asp Leu  Val Tyr Thr Ile Glu  Gln Pro Ser 
    1520                 1525                 1530             


Asn Gly  Arg Val Val Leu Arg  Ala Ala Pro Gly Thr  Glu Val Arg 
    1535                 1540                 1545             


Ser Phe  Thr Gln Ala Gln Leu  Asp Gly Gly Leu Val  Leu Phe Ser 
    1550                 1555                 1560             


His Arg  Gly Ala Leu Asp Gly  Gly Phe Arg Phe Ser  Leu Ser Asp 
    1565                 1570                 1575             


Gly Glu  His Thr Ser Pro Gly  His Phe Phe Arg Val  Thr Ala Gln 
    1580                 1585                 1590             


Lys Gln  Val Leu Leu Ser Leu  Glu Gly Ser Arg Thr  Leu Thr Val 
    1595                 1600                 1605             


Cys Pro  Gly Ser Val Gln Pro  Leu Ser Ser Gln Ser  Leu Arg Ala 
    1610                 1615                 1620             


Ser Ser  Ser Ala Gly Thr Asp  Pro His His Leu Leu  Tyr Arg Val 
    1625                 1630                 1635             


Val Arg  Gly Pro Gln Leu Gly  Arg Leu Phe His Ala  Gln Gln Gly 
    1640                 1645                 1650             


Ser Thr  Gly Glu Ala Leu Val  Asn Phe Thr Gln Ala  Glu Val Tyr 
    1655                 1660                 1665             


Ala Gly  Asn Val Leu Tyr Glu  His Glu Met Pro Pro  Glu Pro Phe 
    1670                 1675                 1680             


Trp Glu  Ala His Asp Thr Leu  Glu Leu Gln Leu Ser  Ser Pro Pro 
    1685                 1690                 1695             


Ala Pro  Asp Val Ala Ala Thr  Leu Ala Val Ala Val  Ser Phe Glu 
    1700                 1705                 1710             


Ala Ala  Cys Pro Gln Arg Pro  Ser Arg Leu Trp Lys  Asn Lys Gly 
    1715                 1720                 1725             


Leu Trp  Val Pro Glu Gly Gln  Arg Ala Glu Ile Thr  Val Ala Ala 
    1730                 1735                 1740             


Leu Asp  Ala Ser Asn Leu Leu  Ala Ser Val Pro Ser  Pro Gln Arg 
    1745                 1750                 1755             


Pro Glu  His Asp Val Leu Phe  Gln Val Thr Gln Phe  Pro Thr Arg 
    1760                 1765                 1770             


Gly Gln  Leu Leu Val Ser Glu  Glu Pro Leu His Ala  Gly Arg Pro 
    1775                 1780                 1785             


His Phe  Leu Gln Ser Glu Leu  Ala Ala Gly Gln Leu  Val Tyr Ala 
    1790                 1795                 1800             


His Gly  Gly Gly Gly Thr Gln  Gln Asp Gly Phe Arg  Phe Arg Ala 
    1805                 1810                 1815             


His Leu  Gln Gly Pro Ala Gly  Ala Ser Val Ala Gly  Pro Gln Thr 
    1820                 1825                 1830             


Ser Glu  Ala Phe Ala Ile Thr  Val Arg Asp Val Asn  Glu Arg Pro 
    1835                 1840                 1845             


Pro Gln  Pro Gln Ala Ser Val  Pro Leu Arg Leu Thr  Arg Gly Ser 
    1850                 1855                 1860             


Arg Ala  Pro Ile Ser Arg Ala  Gln Leu Ser Val Val  Asp Pro Asp 
    1865                 1870                 1875             


Ser Ala  Pro Gly Glu Ile Glu  Tyr Glu Val Gln Arg  Ala Pro His 
    1880                 1885                 1890             


Asn Gly  Phe Leu Ser Leu Val  Gly Gly Gly Pro Gly  Pro Val Thr 
    1895                 1900                 1905             


Arg Phe  Thr Gln Ala Asp Val  Asp Ala Gly Arg Leu  Ala Phe Val 
    1910                 1915                 1920             


Ala Asn  Gly Ser Ser Val Ala  Gly Ile Phe Gln Leu  Ser Met Ser 
    1925                 1930                 1935             


Asp Gly  Ala Ser Pro Pro Leu  Pro Met Ser Leu Ala  Val Asp Val 
    1940                 1945                 1950             


Leu Pro  Ser Ala Ile Glu Val  Gln Leu Arg Ala Pro  Leu Glu Val 
    1955                 1960                 1965             


Pro Gln  Ala Leu Gly Arg Ser  Ser Leu Ser Arg Gln  Gln Leu Arg 
    1970                 1975                 1980             


Val Val  Ser Asp Arg Glu Glu  Pro Asp Ala Ala Tyr  Arg Leu Ile 
    1985                 1990                 1995             


Gln Gly  Pro Gln Tyr Gly His  Leu Leu Val Gly Gly  Gln Pro Ala 
    2000                 2005                 2010             


Ser Ala  Phe Ser Gln Leu Gln  Val Asp Gln Gly Glu  Val Val Phe 
    2015                 2020                 2025             


Ala Phe  Thr Asn Phe Ser Ser  Ser His Asp His Phe  Ser Val Leu 
    2030                 2035                 2040             


Ala Leu  Ala Arg Gly Val Asn  Ala Ser Ala Thr Val  Asn Val Thr 
    2045                 2050                 2055             


Val Arg  Ala Leu Leu His Val  Trp Ala Gly Gly Pro  Trp Pro Gln 
    2060                 2065                 2070             


Gly Ala  Thr Leu Arg Leu Asp  Pro Thr Val Leu Asp  Ala Gly Glu 
    2075                 2080                 2085             


Leu Ala  Asn Arg Thr Gly Ser  Val Pro Arg Phe Arg  Leu Leu Ala 
    2090                 2095                 2100             


Gly Pro  Arg His Gly Arg Val  Val Arg Val Pro Arg  Ala Arg Thr 
    2105                 2110                 2115             


Glu Pro  Gly Gly Ser Gln Leu  Val Glu Gln Phe Thr  Gln Gln Asp 
    2120                 2125                 2130             


Leu Glu  Asp Gly Arg Leu Gly  Leu Glu Val Gly Arg  Pro Glu Gly 
    2135                 2140                 2145             


Arg Ala  Pro Gly Pro Ala Gly  Asp Ser Leu Thr Leu  Glu Leu Trp 
    2150                 2155                 2160             


Ala Gln  Gly Val Pro Pro Ala  Val Ala Ser Leu Asp  Phe Ala Thr 
    2165                 2170                 2175             


Glu Pro  Tyr Asn Ala Ala Arg  Pro Tyr Ser Val Ala  Leu Leu Ser 
    2180                 2185                 2190             


Val Pro  Glu Ala Ala Arg Thr  Glu Ala Gly Lys Pro  Glu Ser Ser 
    2195                 2200                 2205             


Thr Pro  Thr Gly Glu Pro Gly  Pro Met Ala Ser Ser  Pro Val Pro 
    2210                 2215                 2220             


Thr Val  Ala Lys Gly Gly Phe  Leu Gly Phe Leu Glu  Ala Asn Met 
    2225                 2230                 2235             


Phe Ser  Val Ile Ile Pro Val  Cys Leu Val Leu Leu  Leu Leu Ala 
    2240                 2245                 2250             


Leu Ile  Leu Pro Leu Leu Phe  Tyr Leu Arg Lys Arg  Asn Lys Ala 
    2255                 2260                 2265             


Gly Lys  His Asp Val Gln Val  Leu Ala Ala Lys Pro  Arg Asn Gly 
    2270                 2275                 2280             


Leu Ala  Gly Asp Ala Glu Ala  Phe Arg Lys Val Glu  Pro Gly Gln 
    2285                 2290                 2295             


Ala Ile  Pro Leu Ala Ala Val  Pro Gly Gln Gly Ala  Ala Ala Gly 
    2300                 2305                 2310             


Gly Gln  Ala Asp Pro Glu Leu  Leu Gln Phe Cys Arg  Ala Pro Asn 
    2315                 2320                 2325             


Pro Ala  Leu Lys Asn Gly Gln  Tyr Trp Val 
    2330                 2335             


<210>  5
<211>  9974
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full plasmid sequence for pGX1416, comprising CSPG4 coding DNA 
       sequence

<400>  5
gctgcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta       60

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata      120

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat      180

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      240

gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      300

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      360

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat      420

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag      480

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc      540

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga      600

ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga      660

aattaatacg actcactata gggagaccca agctggctag cgtttaaact taagcttggt      720

accgagctcg gatccgccac catggattgg acctggattc tgtttctggt ggccgccgct      780

acaagagtgc attcacagtc tggacctcga ccccctctgc ccgcccctgc actggccctg      840

gctctgaccc tggcaatgct ggcaagagcc tccgccgctt ctttctttgg cgaaaaccac      900

ctggaggtgc ccgtcgctac agcactgact gacatcgatc tgcagctgca gttcagcaca      960

tcccagccag aggccctgct gctgctggca gcaggccctg ctgaccatct gctgctgcag     1020

ctgtacagcg gaagactgca ggtcaggctg gtgctgggac aggaggaact gcgactgcag     1080

acaccagccg agactctgct gtctgatagt gtcccccaca ccgtggtcct gacagtgtca     1140

gacagctggg ccaccctgtc cgtcgatgga ctgctgaacg catctgctcc agtgccagga     1200

gcccctctgg aggtcccata cggactgttc gtgggcggga caggctctct gggactgcca     1260

tatctgcggg ggactagtcg gcccctgaga ggatgcctgc acgctgcaac cctgaatggc     1320

cgctccctgc tgcgaccact gacacctgac gtgcatgagg gctgtgccga ggaattttct     1380

gctggggacg atgtggcact gggattctcc ggaccacact ctctggcagc ttttcctgcc     1440

tggggcaccc aggatgaagg gactctggag ttcaccctga ccacaaggtc ccgccaggct     1500

cccctggcat ttcaggccgg aggccgccac ggcgacttca tctacgtgga tatttttgag     1560

gggcatctgc gggccgtggt cgaaaagggg cagggaacag tgctgctgca caactctgtg     1620

ccagtcgcag acggccagcc ccatgaagtg agtgtccaca tcgacgctca tagactggag     1680

atttcagtgg atcagtaccc tacccggaca agcaatagag gggtgctgtc ctatctggag     1740

ccaaggggaa gcctgctgct gggcggcctg gacgcagagg cctccagaca cctgcaggaa     1800

cataggctgg gcctggctcc cgaagcaaca aacgcctccc tgctggggtg catggaggat     1860

ctgtctgtga atggacagcg aagaggactg cgagaggccc tgctgactcg aaacatggca     1920

gccggatgtc ggctggagga agaggaatat gaggaagacg cttacggccc ttatgaggca     1980

ttcagcaccc tggctcccga agcatggcct gccatggaac tgcctgagcc atgcgtccca     2040

gagcctggac tgcctcccgt gttcgccaac ttcacccagc tgctgactat ctctccactg     2100

gtggtcgcag agggcgggac tgcttggctg gaatggcgac acgtgcagcc caccctggac     2160

ctgagcgagg ccgaactgcg gaaatcccag gtgctgtttt ctgtcaccag gggagctcgc     2220

catggcgagc tggaactgga tattcccgga gctcaggcaa gaaaaatgtt cacactgctg     2280

gacgtggtca accgaaaggc ccggtttgtg cacgatggca gtgaagacac atcagatcag     2340

ctggtgctgg aggtgagtgt cactgccaga ggcccaatgc cctcatgtct gaggcgcggg     2400

cagacctacc tgctgcctat ccaggtcaac ccagtgaatg acccacccag gatcattttc     2460

ccacacgggt ccctgatggt catcctggag catacacaga agccactggg acccgaggtg     2520

ttccaggcct atgaccccga tagcgcctgc gagggcctga cttttcagct gctgggaacc     2580

ccatccggac tgccagtgga acgacgagat cagcctggcg aaccagcaac cgagttcagt     2640

tgtcgcgagc tggaagccgg gtcactggtg tacgtccaca gaggaggccc agcacaggac     2700

ctgaccttcc gggtgagcga tggcctgcag gctagtcctc cagcaactct gaaagtggtc     2760

gccgtgcggc ctgctatcca gattagacat agcaccggac tgaggctggc acagggctcc     2820

gctgcaccca tcctgcctgc caacctgtct gtcgagacca atgctgtggg ccaggacgtg     2880

agtgtcctgt tcagggtgac aggagccctg cagtttggag agctgcagaa gcagggagca     2940

gggggagtgg aaggagcaga gtggtgggct acccaggcat tccaccagcg agatgtcgag     3000

cagggacgag tgcggtacct gagcaccgac ccccagcatc gggcagaaga tacagtggag     3060

aacctggccc tggaggtgca ggtcggacag gaaacactga gtaatctgtc atttcccgtc     3120

accattcaga gggccacagt gtggatgctg cgcctggagc ctctgcacac ccagaacaca     3180

cagcaggagg cactgactac cgcccatctg gaagctactc tggaggaagc aggacctagc     3240

cctcccacct tccactatga ggtggtccag gctccacgca agggcaatct gcagctgcag     3300

ggaactagac tgtctgacgg acaggggttt acccaggacg atctgcaggc aggacgagtg     3360

acctacggag caacagccag agccagtgaa gccgtcgagg ataccttccg gttccgggtg     3420

actgctccac cccacttctc tcccctgtat acttttccta tccatattgg cggggaccca     3480

gatgcacccg tgctgaccaa cgtcctgctg tccgtgccag aaggaggcga gggcgtcctg     3540

agcgcagacc acctgttcgt gaaatccctg aattccgcct cttacctgta tgaagtgatg     3600

gagcgaccac gacatggaag gctggcatgg cgaggaaccc aggacaagac aactatggtg     3660

actagcttca ccaacgagga tctgctgcgg ggcagactgg tgtaccagca cgacgattcc     3720

gaaaccacag aggacgatat cccctttgtg gctactagac agggagaggg ctctggggac     3780

atggcatggg aggaagtccg aggcgtgttc cgggtcgcta tccagcctgt caatgatcac     3840

gcaccagtgc agacaattag ccgcgtgttt catgtcgccc gagggggaag aaggctgctg     3900

actaccgacg atgtggcatt cagcgacgcc gattccggat ttgccgacgc tcagctggtg     3960

ctgaccagga aagatctgct gttcggctcc atcgtggccg tcgacgaacc taccagacca     4020

atctacaggt tcacacagga ggatctgcgc aagcgccgag tgctgtttgt ccactccgga     4080

gcagaccgag gatggattca gctgcaggtg tctgatggcc agcatcaggc aaccgccctg     4140

ctggaagtcc aggcctctga gccctatctg cgcgtggcta acgggagctc cctggtggtc     4200

cctcagggcg ggcagggaac aatcgacact gccgtgctgc acctggacac aaatctggat     4260

attcggagcg gagatgaggt ccactaccat gtgactgctg gaccacgatg gggacagctg     4320

ctgagagcag gacagccagc taccgcattc agtcagcagg acctgctgga tggagccatc     4380

ctgtattcac acaacggcag tctgtcaccc agggacactc tggccttcag cgtcgaggca     4440

ggacctgtgc ataccgatgc cacactgcag gtgaccattg ctctggaagg acccctggca     4500

cctctgcacc tggtccagca taagaaaatc tacgtgttcc agggcgaagc cgctgagatt     4560

cggagagacc agctggaagc agcccaggag gctgtgcctc cagcagatat cgtgttttca     4620

gtcaaaaccc ctcccagcgc cggatacctg gtcatggtga gccacggagc cctggctgac     4680

gaaccaccca gcctggaccc cgtgcagagc ttctcccagg aggcagtcga cgctggacga     4740

gtgctgtatc tgcattcccg gcctgaggcc tggtctgacg cttttagtct ggatgtggct     4800

tctggactgg gcgcaccact ggaaggggtg ctggtcgagc tggaagtgct gcctgctgca     4860

atcccactgg aggcccagaa tttctccgtc cctgaaggag gctctcggac cctggctcct     4920

ccactgctga gagtgaccgg cccatacttt cccacactgc ctggactgtc cctgcaggtg     4980

ctggagcccc ctcagcacgg cgccctgcag agagaggaag gaccccagga caggacactg     5040

agcgccttca gctggagaga agtcgaggaa cagctgattc gctatgtgca cgacggcagt     5100

gagactctga ccgattcatt cgtgctggtc gcaaacgcca gcgaaatgga ccggcagtcc     5160

catccagtcg cctttacagt gactatcctg cccgtgaacg atcagccacc cattctgaca     5220

actaatacag ggctgcagat gtgggaagga gccactgtgc ctatcccagc tgaggcactg     5280

agaagtaccg acggggattc aggacctgag gacctggtgt acacaattga acagccaagc     5340

aatggacgag tggtcctgcg agcagctcca ggaactgagg tgaggtcttt cacccaggca     5400

cagctggatg ggggactggt gctgtttagt caccgaggcg ctctggacgg cgggttcagg     5460

ttttctctga gtgatggcga gcacacctcc cctgggcatt tctttagagt cacagcccag     5520

aagcaggtgc tgctgtcact ggaagggagc aggaccctga cagtctgccc aggatctgtg     5580

cagcccctgt ctagtcagag tctgcgagca tcaagctccg ccggaaccga ccctcaccat     5640

ctgctgtata gagtggtcag gggaccacag ctgggacggc tgttccatgc acagcagggc     5700

agcacagggg aagccctggt gaactttact caggctgagg tctacgcagg caatgtgctg     5760

tatgagcacg aaatgcctcc agaacccttc tgggaggccc atgacaccct ggagctgcag     5820

ctgtctagtc cccctgctcc tgatgtggca gccacactgg ccgtggctgt ctcctttgag     5880

gctgcatgtc cacagcgccc ctctcgactg tggaagaaca aaggactgtg ggtgccagaa     5940

ggacagcgag cagagatcac cgtggccgct ctggacgcct ccaatctgct ggcttctgtg     6000

cccagtcctc agcggccaga gcacgatgtc ctgttccaag tgactcagtt tcccaccaga     6060

ggacagctgc tggtgtcaga ggaaccactg cacgcaggca ggcctcattt cctgcagagc     6120

gagctggcag caggacagct ggtgtacgca cacggaggcg ggggaaccca gcaggacggc     6180

ttcaggtttc gcgcacatct gcagggacct gcaggagcat cagtggctgg accacagact     6240

agcgaagctt ttgcaatcac cgtgcgagat gtcaacgagc ggccacccca gcctcaggca     6300

agcgtgccac tgcgactgac aagagggagc agggcaccta tctccagagc ccagctgtct     6360

gtggtcgacc ccgatagcgc acctggagag attgaatatg aggtgcagag ggccccacac     6420

aacggattcc tgtccctggt cggcggggga ccaggaccag tgactcggtt cacccaggca     6480

gacgtggatg ctggcaggct ggcattcgtc gccaatggct caagcgtggc tgggatcttt     6540

cagctgtcaa tgagcgacgg ggcatctcct ccactgccta tgagtctggc agtggatgtc     6600

ctgccatccg ccattgaggt ccagctgcga gctccactgg aagtgccaca ggcactgggc     6660

cggtcctctc tgtcacggca gcagctgaga gtggtcagcg accgcgagga acccgatgct     6720

gcataccggc tgatccaggg ccctcagtat ggacacctgc tggtgggcgg gcagccagca     6780

tcagctttca gccagctgca ggtggaccag ggagaggtgg tcttcgcctt taccaacttc     6840

agttcaagcc acgatcattt ttcagtcctg gcactggcca gaggagtgaa cgctagcgca     6900

acagtgaatg tcactgtgag ggccctgctg cacgtgtggg ctggaggccc ttggccacag     6960

ggagccacac tgcgactgga ccctactgtg ctggatgcag gagagctggc aaatcgaacc     7020

ggcagcgtgc cacgattccg gctgctggca ggacctcgac atggacgagt ggtccgggtg     7080

ccaagagcta ggactgagcc cggcggcagc cagctggtgg aacagtttac ccagcaggac     7140

ctggaggatg ggcggctggg actggaagtg gggaggcctg agggacgagc tccaggacct     7200

gcaggggaca gtctgacact ggagctgtgg gcacagggag tgcctcccgc agtggcttca     7260

ctggatttcg ctactgaacc ttacaacgcc gctagaccat atagtgtcgc cctgctgtca     7320

gtgccagaag cagccaggac tgaggctggg aaacccgaat cctctactcc taccggagag     7380

ccaggcccca tggctagttc acctgtgcca accgtcgcaa agggcgggtt cctgggattt     7440

ctggaggcca atatgttcag cgtgatcatt ccagtgtgcc tggtcctgct gctgctggcc     7500

ctgatcctgc ccctgctgtt ttacctgcgc aagcgaaaca aagccggaaa gcacgacgtg     7560

caggtgctgg ctgcaaaacc tagaaatggg ctggccggag atgcagaggc cttcaggaag     7620

gtggaaccag gccaggctat tcccctggcc gctgtgcctg ggcagggagc agccgctgga     7680

ggccaggccg acccagagct gctgcagttt tgtagagccc ctaatcccgc cctgaagaat     7740

ggacagtatt gggtctgata actcgagtct agagggcccg tttaaacccg ctgatcagcc     7800

tcgactgtgc cttctagttg ccagccatct gttgtttgcc cctcccccgt gccttccttg     7860

accctggaag gtgccactcc cactgtcctt tcctaataaa atgaggaaat tgcatcgcat     7920

tgtctgagta ggtgtcattc tattctgggg ggtggggtgg ggcaggacag caagggggag     7980

gattgggaag acaatagcag gcatgctggg gatgcggtgg gctctatggc ttctactggg     8040

cggttttatg gacagcaagc gaaccggaat tgccagctgg ggcgccctct ggtaaggttg     8100

ggaagccctg caaagtaaac tggatggctt tcttgccgcc aaggatctga tggcgcaggg     8160

gatcaagctc tgatcaagag acaggatgag gatcgtttcg catgattgaa caagatggat     8220

tgcacgcagg ttctccggcc gcttgggtgg agaggctatt cggctatgac tgggcacaac     8280

agacaatcgg ctgctctgat gccgccgtgt tccggctgtc agcgcagggg cgcccggttc     8340

tttttgtcaa gaccgacctg tccggtgccc tgaatgaact gcaagacgag gcagcgcggc     8400

tatcgtggct ggccacgacg ggcgttcctt gcgcagctgt gctcgacgtt gtcactgaag     8460

cgggaaggga ctggctgcta ttgggcgaag tgccggggca ggatctcctg tcatctcacc     8520

ttgctcctgc cgagaaagta tccatcatgg ctgatgcaat gcggcggctg catacgcttg     8580

atccggctac ctgcccattc gaccaccaag cgaaacatcg catcgagcga gcacgtactc     8640

ggatggaagc cggtcttgtc gatcaggatg atctggacga agagcatcag gggctcgcgc     8700

cagccgaact gttcgccagg ctcaaggcga gcatgcccga cggcgaggat ctcgtcgtga     8760

cccatggcga tgcctgcttg ccgaatatca tggtggaaaa tggccgcttt tctggattca     8820

tcgactgtgg ccggctgggt gtggcggacc gctatcagga catagcgttg gctacccgtg     8880

atattgctga agagcttggc ggcgaatggg ctgaccgctt cctcgtgctt tacggtatcg     8940

ccgctcccga ttcgcagcgc atcgccttct atcgccttct tgacgagttc ttctgaatta     9000

ttaacgctta caatttcctg atgcggtatt ttctccttac gcatctgtgc ggtatttcac     9060

accgcatcag gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc     9120

taaatacatt caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa     9180

tagcacgtgc taaaacttca tttttaattt aaaaggatct aggtgaagat cctttttgat     9240

aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc agaccccgta     9300

gaaaagatca aaggatcttc ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa     9360

acaaaaaaac caccgctacc agcggtggtt tgtttgccgg atcaagagct accaactctt     9420

tttccgaagg taactggctt cagcagagcg cagataccaa atactgttct tctagtgtag     9480

ccgtagttag gccaccactt caagaactct gtagcaccgc ctacatacct cgctctgcta     9540

atcctgttac cagtggctgc tgccagtggc gataagtcgt gtcttaccgg gttggactca     9600

agacgatagt taccggataa ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag     9660

cccagcttgg agcgaacgac ctacaccgaa ctgagatacc tacagcgtga gctatgagaa     9720

agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga     9780

acaggagagc gcacgaggga gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc     9840

gggtttcgcc acctctgact tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc     9900

ctatggaaaa acgccagcaa cgcggccttt ttacggttcc tggccttttg ctggcctttt     9960

gctcacatgt tctt                                                       9974


